Minimum Information about a Biosynthetic Gene cluster
Names
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Minimum Information about a Biosynthetic Gene cluster
metasource: Fairsharing.org
version: FAIRsharing.org: MIBiG; Minimum Information about a Biosynthetic Gene cluster; DOI: https://doi.org/10.25504/FAIRsharing.jqfgxs; Last edited: May 20, 2021, 2:03 p.m.; Last accessed: Jan 03 2022 7:12 p.m.
MIBiG
metasource: Fairsharing.org
version: FAIRsharing.org: MIBiG; Minimum Information about a Biosynthetic Gene cluster; DOI: https://doi.org/10.25504/FAIRsharing.jqfgxs; Last edited: May 20, 2021, 2:03 p.m.; Last accessed: Jan 03 2022 7:12 p.m.
MIBiG 2.0
metasource: bio.tools
version: extracted_at: 2022-11-04T11:29:23.808068
MIBiG_2.0
metasource: bio.tools
version: extracted_at: 2022-11-04T11:29:23.808068
Names
More detailed information about this field from each metasource.
Minimum Information about a Biosynthetic Gene cluster
metasource: Fairsharing.orgversion: FAIRsharing.org: MIBiG; Minimum Information about a Biosynthetic Gene cluster; DOI: https://doi.org/10.25504/FAIRsharing.jqfgxs; Last edited: May 20, 2021, 2:03 p.m.; Last accessed: Jan 03 2022 7:12 p.m.
MIBiG
metasource: Fairsharing.orgversion: FAIRsharing.org: MIBiG; Minimum Information about a Biosynthetic Gene cluster; DOI: https://doi.org/10.25504/FAIRsharing.jqfgxs; Last edited: May 20, 2021, 2:03 p.m.; Last accessed: Jan 03 2022 7:12 p.m.
MIBiG 2.0
metasource: bio.toolsversion: extracted_at: 2022-11-04T11:29:23.808068
MIBiG_2.0
metasource: bio.toolsversion: extracted_at: 2022-11-04T11:29:23.808068
Other names: MIBiG, MIBiG 2.0, MIBiG_2.0
Names
More detailed information about this field from each metasource.
Minimum Information about a Biosynthetic Gene cluster
metasource: Fairsharing.orgversion: FAIRsharing.org: MIBiG; Minimum Information about a Biosynthetic Gene cluster; DOI: https://doi.org/10.25504/FAIRsharing.jqfgxs; Last edited: May 20, 2021, 2:03 p.m.; Last accessed: Jan 03 2022 7:12 p.m.
MIBiG
metasource: Fairsharing.orgversion: FAIRsharing.org: MIBiG; Minimum Information about a Biosynthetic Gene cluster; DOI: https://doi.org/10.25504/FAIRsharing.jqfgxs; Last edited: May 20, 2021, 2:03 p.m.; Last accessed: Jan 03 2022 7:12 p.m.
MIBiG 2.0
metasource: bio.toolsversion: extracted_at: 2022-11-04T11:29:23.808068
MIBiG_2.0
metasource: bio.toolsversion: extracted_at: 2022-11-04T11:29:23.808068
A wide variety of enzymatic pathways that produce specialized metabolites in bacteria, fungi and plants are known to be encoded in biosynthetic gene clusters. Information about these clusters, pathways and metabolites is currently dispersed throughout the literature, making it difficult to exploit. The Minimum Information about a Biosynthetic Gene cluster (MIBiG) data standard was created to facilitate consistent and systematic deposition and retrieval of data on biosynthetic gene clusters.
Description
More detailed information about this field from each metasource.
A wide variety of enzymatic pathways that produce specialized metabolites in bacteria, fungi and plants are known to be encoded in biosynthetic gene clusters. Information about these clusters, pathways and metabolites is currently dispersed throughout the literature, making it difficult to exploit. The Minimum Information about a Biosynthetic Gene cluster (MIBiG) data standard was created to facilitate consistent and systematic deposition and retrieval of data on biosynthetic gene clusters.
metasource: Fairsharing.orgversion: FAIRsharing.org: MIBiG; Minimum Information about a Biosynthetic Gene cluster; DOI: https://doi.org/10.25504/FAIRsharing.jqfgxs; Last edited: May 20, 2021, 2:03 p.m.; Last accessed: Jan 03 2022 7:12 p.m.
A repository for biosynthetic gene clusters of known function. REST API layer for the MIBiG database. Repository to track changes in MIBiG curation data stored in JSON format. Minimum Information about a Biosynthetic Gene cluster. Refactor MIBiG (version 1.4: August 6th, 2018) JSON schema, both structurally and conceptually. Adopt the latest JSON schema (Draft V7), and update existing data to match the new schema.
metasource: bio.toolsversion: extracted_at: 2022-11-04T11:29:23.808068
Webpage:
http://mibig.secondarymetabolites.org/Webpage
More detailed information about this field from each metasource.
http://mibig.secondarymetabolites.org/
metasource: Fairsharing.orgversion: FAIRsharing.org: MIBiG; Minimum Information about a Biosynthetic Gene cluster; DOI: https://doi.org/10.25504/FAIRsharing.jqfgxs; Last edited: May 20, 2021, 2:03 p.m.; Last accessed: Jan 03 2022 7:12 p.m.
https://mibig.secondarymetabolites.org/
metasource: bio.toolsversion: extracted_at: 2022-11-04T11:29:23.808068
Licence:
Name: Creative Commons Attribution 4.0 International (CC BY 4.0)Licence name
More detailed information about this field from each metasource.
Creative Commons Attribution 4.0 International (CC BY 4.0)
metasource: Fairsharing.orgversion: FAIRsharing.org: MIBiG; Minimum Information about a Biosynthetic Gene cluster; DOI: https://doi.org/10.25504/FAIRsharing.jqfgxs; Last edited: May 20, 2021, 2:03 p.m.; Last accessed: Jan 03 2022 7:12 p.m.
Apache-2.0
metasource: bio.toolsversion: extracted_at: 2022-11-04T11:29:23.808068
Licence URL
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https://creativecommons.org/licenses/by/4.0/
metasource: Fairsharing.orgversion: FAIRsharing.org: MIBiG; Minimum Information about a Biosynthetic Gene cluster; DOI: https://doi.org/10.25504/FAIRsharing.jqfgxs; Last edited: May 20, 2021, 2:03 p.m.; Last accessed: Jan 03 2022 7:12 p.m.
Publications:
Publications
More detailed information about this field from each metasource.
Minimum Information about a Biosynthetic Gene cluster
PMID: 26284661
metasource: Fairsharing.org
version: FAIRsharing.org: MIBiG; Minimum Information about a Biosynthetic Gene cluster; DOI: https://doi.org/10.25504/FAIRsharing.jqfgxs; Last edited: May 20, 2021, 2:03 p.m.; Last accessed: Jan 03 2022 7:12 p.m.
MIBiG 2.0: a repository for biosynthetic gene clusters of known function
PMID: 31612915
metasource: bio.tools
version: extracted_at: 2022-11-04T11:29:23.808068
Publications
More detailed information about this field from each metasource.
Minimum Information about a Biosynthetic Gene cluster
PMID: 26284661
metasource: Fairsharing.org
version: FAIRsharing.org: MIBiG; Minimum Information about a Biosynthetic Gene cluster; DOI: https://doi.org/10.25504/FAIRsharing.jqfgxs; Last edited: May 20, 2021, 2:03 p.m.; Last accessed: Jan 03 2022 7:12 p.m.
MIBiG 2.0: a repository for biosynthetic gene clusters of known function
PMID: 31612915
metasource: bio.tools
version: extracted_at: 2022-11-04T11:29:23.808068
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Minimum Information about a Biosynthetic Gene cluster
PubMed citations: 299.
299 articles citing: Minimum Information about a Biosynthetic Gene cluster
Penicillium chrysogenum, a Vintage Model with a Cutting-Edge Profile in Biotechnology. PMID:35336148
New Glycosylated Polyene Macrolides: Refining the Ore from Genome Mining. PMID:35326797
Integrated Genomic and Metabolomic Analysis Illuminates Key Secreted Metabolites Produced by the Novel Endophyte Bacillus halotolerans Cal.l.30 Involved in Diverse Biological Control Activities. PMID:35208854
Genome Mining and Analysis of PKS Genes in Eurotium cristatum E1 Isolated from Fuzhuan Brick Tea. PMID:35205947
Unveiling the genomic potential of Pseudomonas type strains for discovering new natural products. PMID:35195510
Draft Genome Sequence of Brevibacillus brevis LABIM17, a Biotechnologically Important Antimicrobial-Producing Bacterium. PMID:35191747
In silico analyses of maleidride biosynthetic gene clusters. PMID:35177129
Comparative Genomics Reveal the Animal-Associated Features of the Acanthopleuribacteraceae Bacteria, and Description of Sulfidibacter corallicola gen. nov., sp., nov. PMID:35173698
Biosynthetic Potential of the Endophytic Fungus Helotiales sp. BL73 Revealed via Compound Identification and Genome Mining. PMID:35108081
Meta-QTLs, ortho-meta-QTLs and candidate genes for grain yield and associated traits in wheat (Triticum aestivum L.). PMID:34985537
Genome Mining of Pseudomonas Species: Diversity and Evolution of Metabolic and Biosynthetic Potential. PMID:34946606
Genomic and Metabolomic Insights into Secondary Metabolites of the Novel Bacillus halotolerans Hil4, an Endophyte with Promising Antagonistic Activity against Gray Mold and Plant Growth Promoting Potential. PMID:34946110
Secondary metabolite biosynthetic diversity in Arctic Ocean metagenomes. PMID:34904945
A Multidisciplinary Approach to Unraveling the Natural Product Biosynthetic Potential of a Streptomyces Strain Collection Isolated from Leaf-Cutting Ants. PMID:34835350
Vertical Inheritance Facilitates Interspecies Diversification in Biosynthetic Gene Clusters and Specialized Metabolites. PMID:34809466
Activation and Identification of a Griseusin Cluster in Streptomyces sp. CA-256286 by Employing Transcriptional Regulators and Multi-Omics Methods. PMID:34770989
Synthaser: a CD-Search enabled Python toolkit for analysing domain architecture of fungal secondary metabolite megasynth(et)ases. PMID:34763725
Synthetic biology of plant natural products: From pathway elucidation to engineered biosynthesis in plant cells. PMID:34746761
Mining the Microbiome and Microbiota-Derived Molecules in Inflammatory Bowel Disease. PMID:34681902
Looking Back to Amycolatopsis: History of the Antibiotic Discovery and Future Prospects. PMID:34680834
Nerpa: A Tool for Discovering Biosynthetic Gene Clusters of Bacterial Nonribosomal Peptides. PMID:34677408
Characterization and engineering of Streptomyces griseofuscus DSM 40191 as a potential host for heterologous expression of biosynthetic gene clusters. PMID:34526549
Integrating perspectives in actinomycete research: an ActinoBase review of 2020-21. PMID:34515628
Plant Metabolic Gene Clusters: Evolution, Organization, and Their Applications in Synthetic Biology. PMID:34490002
Insights into the Variation in Bioactivities of Closely Related Streptomyces Strains from Marine Sediments of the Visayan Sea against ESKAPE and Ovarian Cancer. PMID:34436280
Comparative Genomics Reveals a Remarkable Biosynthetic Potential of the Streptomyces Phylogenetic Lineage Associated with Rugose-Ornamented Spores. PMID:34427515
Identification of Oral Bacterial Biosynthetic Gene Clusters Associated with Caries. PMID:34410645
Alternative metabolic pathways and strategies to high-titre terpenoid production in Escherichia coli. PMID:34231643
Comparative Genomic Insights Into the Taxonomic Classification, Diversity, and Secondary Metabolic Potentials of Kitasatospora, a Genus Closely Related to Streptomyces. PMID:34194415
Linking a Gene Cluster to Atranorin, a Major Cortical Substance of Lichens, through Genetic Dereplication and Heterologous Expression. PMID:34154413
MolDiscovery: learning mass spectrometry fragmentation of small molecules. PMID:34140479
Cyanochelins, an Overlooked Class of Widely Distributed Cyanobacterial Siderophores, Discovered by Silent Gene Cluster Awakening. PMID:34132591
Mining genomes to illuminate the specialized chemistry of life. PMID:34083778
Salicylic Acid Biosynthesis and Metabolism: A Divergent Pathway for Plants and Bacteria. PMID:34065121
Draft Genome Sequences of Five Fungal Strains Isolated from Kefir. PMID:34042484
A Machine Learning Bioinformatics Method to Predict Biological Activity from Biosynthetic Gene Clusters. PMID:34042443
Deep Large-Scale Multitask Learning Network for Gene Expression Inference. PMID:34014778
Synergizing the potential of bacterial genomics and metabolomics to find novel antibiotics. PMID:33995996
Ranking microbial metabolomic and genomic links in the NPLinker framework using complementary scoring functions. PMID:33945539
An interpreted atlas of biosynthetic gene clusters from 1,000 fungal genomes. PMID:33941694
Deciphering the Monilinia fructicola Genome to Discover Effector Genes Possibly Involved in Virulence. PMID:33919788
Phylogenomic Insights into Distribution and Adaptation of Bdellovibrionota in Marine Waters. PMID:33916768
Anaerobic gut fungi are an untapped reservoir of natural products. PMID:33906945
Coelimycin Synthesis Activatory Proteins Are Key Regulators of Specialized Metabolism and Precursor Flux in Streptomyces coelicolor A3(2). PMID:33897632
The Pectobacterium pangenome, with a focus on Pectobacterium brasiliense, shows a robust core and extensive exchange of genes from a shared gene pool. PMID:33849459
Unexpected genomic, biosynthetic and species diversity of Streptomyces bacteria from bats in Arizona and New Mexico, USA. PMID:33827425
The ecological roles of microbial lipopeptides: Where are we going? PMID:33777336
Genomic insights into biocontrol potential of edible seaweed-associated Bacillus velezensis MTCC 10456 from Gulf of Mannar. PMID:33770230
Metagenomic insights into the taxonomy, function, and dysbiosis of prokaryotic communities in octocorals. PMID:33766108
Deep learning approaches for natural product discovery from plant endophytic microbiomes. PMID:33758794
Blocks in the pseudouridimycin pathway unlock hidden metabolites in the Streptomyces producer strain. PMID:33712632
Phylogenetic Distribution of Secondary Metabolites in the Bacillus subtilis Species Complex. PMID:33688015
Evolution of combinatorial diversity in trans-acyltransferase polyketide synthase assembly lines across bacteria. PMID:33658492
The Food Poisoning Toxins of Bacillus cereus. PMID:33525722
Genomic Insights Into the Antifungal Activity and Plant Growth-Promoting Ability in Bacillus velezensis CMRP 4490. PMID:33519779
The Use of the Rare TTA Codon in Streptomyces Genes: Significance of the Codon Context? PMID:33505089
Genome analysis of a halophilic bacterium Halomonas malpeensis YU-PRIM-29T reveals its exopolysaccharide and pigment producing capabilities. PMID:33462335
Diverse Taxonomies for Diverse Chemistries: Enhanced Representation of Natural Product Metabolism in UniProtKB. PMID:33445429
A Multi-Omics Characterization of the Natural Product Potential of Tropical Filamentous Marine Cyanobacteria. PMID:33418911
SYN-View: A Phylogeny-Based Synteny Exploration Tool for the Identification of Gene Clusters Linked to Antibiotic Resistance. PMID:33396183
The Integration of Genome Mining, Comparative Genomics, and Functional Genetics for Biosynthetic Gene Cluster Identification. PMID:33343637
Production of the antimicrobial compound tetrabromopyrrole and the Pseudomonas quinolone system precursor, 2-heptyl-4-quinolone, by a novel marine species Pseudoalteromonas galatheae sp. nov. PMID:33303891
Dynamics in Secondary Metabolite Gene Clusters in Otherwise Highly Syntenic and Stable Genomes in the Fungal Genus Botrytis. PMID:33283866
Recent developments of tools for genome and metabolome studies in basidiomycete fungi and their application to natural product research. PMID:33268478
Comprehensive prediction of secondary metabolite structure and biological activity from microbial genome sequences. PMID:33247171
The antiSMASH database version 3: increased taxonomic coverage and new query features for modular enzymes. PMID:33152079
Secretion of and Self-Resistance to the Novel Fibupeptide Antimicrobial Lugdunin by Distinct ABC Transporters in Staphylococcus lugdunensis. PMID:33106269
Cryptic or Silent? The Known Unknowns, Unknown Knowns, and Unknown Unknowns of Secondary Metabolism. PMID:33082252
Discovery of an Abundance of Biosynthetic Gene Clusters in Shark Bay Microbial Mats. PMID:32973707
Genome Mining, Microbial Interactions, and Molecular Networking Reveals New Dibromoalterochromides from Strains of Pseudoalteromonas of Coiba National Park-Panama. PMID:32899199
RRE-Finder: a Genome-Mining Tool for Class-Independent RiPP Discovery. PMID:32873609
Microbial natural product databases: moving forward in the multi-omics era. PMID:32856641
Comparative genomic analysis of Flavobacteriaceae: insights into carbohydrate metabolism, gliding motility and secondary metabolite biosynthesis. PMID:32819293
Impact of lifestyle on cytochrome P450 monooxygenase repertoire is clearly evident in the bacterial phylum Firmicutes. PMID:32814804
Identifying the Compounds of the Metabolic Elicitors of Pseudomonas fluorescens N 21.4 Responsible for Their Ability to Induce Plant Resistance. PMID:32806693
Culturable diversity of bacterial endophytes associated with medicinal plants of the Western Ghats, India. PMID:32710748
Synthetic-Bioinformatic Natural Product Antibiotics with Diverse Modes of Action. PMID:32697091
The In Silico Characterization of a Salicylic Acid Analogue Coding Gene Clusters in Selected Pseudomonas fluorescens Strains. PMID:32671125
Exploiting the Biosynthetic Potency of Taxol from Fungal Endophytes of Conifers Plants; Genome Mining and Metabolic Manipulation. PMID:32630044
Hawaiian Bobtail Squid Symbionts Inhibit Marine Bacteria via Production of Specialized Metabolites, Including New Bromoalterochromides BAC-D/D'. PMID:32611694
Genotyping-Guided Discovery of Persiamycin A From Sponge-Associated Halophilic Streptomonospora sp. PA3. PMID:32582127
Precursor peptide-targeted mining of more than one hundred thousand genomes expands the lanthipeptide natural product family. PMID:32493223
Comparative Genomics and Metabolomics in the Genus Nocardia. PMID:32487740
Mining the Biosynthetic Potential for Specialized Metabolism of a Streptomyces Soil Community. PMID:32456220
Chemical, Bioactivity, and Biosynthetic Screening of Epiphytic Fungus Zasmidium pseudotsugae. PMID:32438585
Exploring novel bacterial terpene synthases. PMID:32353014
Multicomponent Microscale Biosynthesis of Unnatural Cyanobacterial Indole Alkaloids. PMID:32302487
A Two-Component regulatory system with opposite effects on glycopeptide antibiotic biosynthesis and resistance. PMID:32277112
Streptomyces spp. From the Marine Sponge Antho dichotoma: Analyses of Secondary Metabolite Biosynthesis Gene Clusters and Some of Their Products. PMID:32256483
The hidden enzymology of bacterial natural product biosynthesis. PMID:32232178
Aspergillus flavus Secondary Metabolites: More than Just Aflatoxins. PMID:32231944
Novel approach in whole genome mining and transcriptome analysis reveal conserved RiPPs in Trichoderma spp. PMID:32216757
Diversification of polyketide structures via synthase engineering. PMID:32180918
Antimicrobial biosynthetic potential and diversity of culturable soil actinobacteria from forest ecosystems of Northeast India. PMID:32139731
A comparative genomics study of 23 Aspergillus species from section Flavi. PMID:32107379
Microfluidic automated plasmid library enrichment for biosynthetic gene cluster discovery. PMID:32095820
Diversity of Bacterial Biosynthetic Genes in Maritime Antarctica. PMID:32085500
Establishment of recombineering genome editing system in Paraburkholderia megapolitana empowers activation of silent biosynthetic gene clusters. PMID:32053291
Identification and Heterologous Expression of the Biosynthetic Gene Cluster Encoding the Lasso Peptide Humidimycin, a Caspofungin Activity Potentiator. PMID:32046042
Evolutionary Histories of Type III Polyketide Synthases in Fungi. PMID:32038517
Genome mining of biosynthetic and chemotherapeutic gene clusters in Streptomyces bacteria. PMID:32029878
Linking Genes to Molecules in Eukaryotic Sources: An Endeavor to Expand Our Biosynthetic Repertoire. PMID:32023950
Monasone Naphthoquinone Biosynthesis and Resistance in Monascus Fungi. PMID:32019788
Genome-based analysis for the bioactive potential of Streptomyces yeochonensis CN732, an acidophilic filamentous soil actinobacterium. PMID:32013859
Isolation, Genomic and Metabolomic Characterization of Streptomyces tendae VITAKN with Quorum Sensing Inhibitory Activity from Southern India. PMID:31963137
Annotated Genome Sequence of Aspergillus tanneri NIH1004. PMID:31948962
Biosynthetic gene clusters and the evolution of fungal chemodiversity. PMID:31898704
Bacterial terpene biosynthesis: challenges and opportunities for pathway engineering. PMID:31839835
Evolution and Diversity of Assembly-Line Polyketide Synthases. PMID:31838842
The Natural Products Atlas: An Open Access Knowledge Base for Microbial Natural Products Discovery. PMID:31807684
Diversity, Ecology, and Prevalence of Antimicrobials in Nature. PMID:31803148
A computational framework to explore large-scale biosynthetic diversity. PMID:31768033
Engineering enzymatic assembly lines to produce new antibiotics. PMID:31743841
Cultivation and functional characterization of 79 planctomycetes uncovers their unique biology. PMID:31740763
Genus level analysis of PKS-NRPS and NRPS-PKS hybrids reveals their origin in Aspergilli. PMID:31722662
Norine: update of the nonribosomal peptide resource. PMID:31691799
IMG-ABC v.5.0: an update to the IMG/Atlas of Biosynthetic Gene Clusters Knowledgebase. PMID:31665416
MetaMiner: A Scalable Peptidogenomics Approach for Discovery of Ribosomal Peptide Natural Products with Blind Modifications from Microbial Communities. PMID:31629686
Taxonomic and Metabolic Incongruence in the Ancient Genus Streptomyces. PMID:31616394
MIBiG 2.0: a repository for biosynthetic gene clusters of known function. PMID:31612915
MetaMed: Linking Microbiota Functions with Medicine Therapeutics. PMID:31594829
Drug Resistance and the Prevention Strategies in Food Borne Bacteria: An Update Review. PMID:31592430
Genome Mining Coupled with OSMAC-Based Cultivation Reveal Differential Production of Surugamide A by the Marine Sponge Isolate Streptomyces sp. SM17 When Compared to Its Terrestrial Relative S. albidoflavus J1074. PMID:31561472
Structural basis for chain release from the enacyloxin polyketide synthase. PMID:31548674
Loci Encoding Compounds Potentially Active against Drug-Resistant Pathogens amidst a Decreasing Pool of Novel Antibiotics. PMID:31540982
NPS: scoring and evaluating the statistical significance of peptidic natural product-spectrum matches. PMID:31510666
Culture-Dependent Bioprospecting of Bacterial Isolates From the Canadian High Arctic Displaying Antibacterial Activity. PMID:31447822
A Single Biosynthetic Gene Cluster Is Responsible for the Production of Bagremycin Antibiotics and Ferroverdin Iron Chelators. PMID:31409675
Engineering actinomycetes for biosynthesis of macrolactone polyketides. PMID:31409353
Comparative Genomics of Marine Sponge-Derived Streptomyces spp. Isolates SM17 and SM18 With Their Closest Terrestrial Relatives Provides Novel Insights Into Environmental Niche Adaptations and Secondary Metabolite Biosynthesis Potential. PMID:31404169
A deep learning genome-mining strategy for biosynthetic gene cluster prediction. PMID:31400112
A polyketide synthase gene cluster associated with the sexual reproductive cycle of the banana pathogen, Pseudocercospora fijiensis. PMID:31344104
Assembling a plug-and-play production line for combinatorial biosynthesis of aromatic polyketides in Escherichia coli. PMID:31318855
Phylogenomic analyses and distribution of terpene synthases among Streptomyces. PMID:31293665
Linking biosynthetic and chemical space to accelerate microbial secondary metabolite discovery. PMID:31252431
Multi-level regulation of coelimycin synthesis in Streptomyces coelicolor A3(2). PMID:31250060
Survey of Biosynthetic Gene Clusters from Sequenced Myxobacteria Reveals Unexplored Biosynthetic Potential. PMID:31238501
Genetic platforms for heterologous expression of microbial natural products. PMID:31197291
Biochemical Characteristics of Microbial Enzymes and Their Significance from Industrial Perspectives. PMID:31168761
Protocols for yTREX/Tn5-based gene cluster expression in Pseudomonas putida. PMID:31162833
BiosyntheticSPAdes: reconstructing biosynthetic gene clusters from assembly graphs. PMID:31160374
Cytochrome P450 Monooxygenase CYP139 Family Involved in the Synthesis of Secondary Metabolites in 824 Mycobacterial Species. PMID:31159249
Whole Genome Sequencing and Metabolomic Study of Cave Streptomyces Isolates ICC1 and ICC4. PMID:31134037
Direct cloning and heterologous expression of natural product biosynthetic gene clusters by transformation-associated recombination. PMID:31128791
Omics Technologies to Understand Activation of a Biosynthetic Gene Cluster in Micromonospora sp. WMMB235: Deciphering Keyicin Biosynthesis. PMID:31120241
Microbial community drivers of PK/NRP gene diversity in selected global soils. PMID:31118083
The Bacillus cereus Group: Bacillus Species with Pathogenic Potential. PMID:31111815
Synthetic biology strategies for microbial biosynthesis of plant natural products. PMID:31086174
Unearthing fungal chemodiversity and prospects for drug discovery. PMID:31071615
antiSMASH 5.0: updates to the secondary metabolite genome mining pipeline. PMID:31032519
Identification of the Bacterial Biosynthetic Gene Clusters of the Oral Microbiome Illuminates the Unexplored Social Language of Bacteria during Health and Disease. PMID:30992349
LanI-Mediated Lantibiotic Immunity in Bacillus subtilis: Functional Analysis. PMID:30952662
EvoMining reveals the origin and fate of natural product biosynthetic enzymes. PMID:30946645
Chemical Ecology of Marine Sponges: New Opportunities through "-Omics". PMID:30942859
Diazaquinomycin Biosynthetic Gene Clusters from Marine and Freshwater Actinomycetes. PMID:30896942
Antibacterial and anticancer activities of orphan biosynthetic gene clusters from Atlantis II Red Sea brine pool. PMID:30885206
Computational identification of co-evolving multi-gene modules in microbial biosynthetic gene clusters. PMID:30854475
Refactoring the Cryptic Streptophenazine Biosynthetic Gene Cluster Unites Phenazine, Polyketide, and Nonribosomal Peptide Biochemistry. PMID:30853419
New Approaches to Detect Biosynthetic Gene Clusters in the Environment. PMID:30823559
Inter-Modular Linkers play a crucial role in governing the biosynthesis of non-ribosomal peptides. PMID:30785185
Detection of Natural Products and Their Producers in Ocean Sediments. PMID:30737349
Marine biofilms constitute a bank of hidden microbial diversity and functional potential. PMID:30705275
The antimicrobial potential of Streptomyces from insect microbiomes. PMID:30705269
Targeted Rediscovery and Biosynthesis of the Farnesyl-Transferase Inhibitor Pepticinnamin E. PMID:30694017
A selective genome-guided method for environmental Burkholderia isolation. PMID:30680473
Investigations into PoyH, a promiscuous protease from polytheonamide biosynthesis. PMID:30627933
Biosynthetic Gene Content of the 'Perfume Lichens' Evernia prunastri and Pseudevernia furfuracea. PMID:30626017
Sequence-based classification of type II polyketide synthase biosynthetic gene clusters for antiSMASH. PMID:30610412
Competition among Nasal Bacteria Suggests a Role for Siderophore-Mediated Interactions in Shaping the Human Nasal Microbiota. PMID:30578265
Uncovering secondary metabolite evolution and biosynthesis using gene cluster networks and genetic dereplication. PMID:30560908
Fungal secondary metabolism: regulation, function and drug discovery. PMID:30531948
Natural product drug discovery in the genomic era: realities, conjectures, misconceptions, and opportunities. PMID:30484124
Conditional generative adversarial network for gene expression inference. PMID:30423066
Analysis of the Genome and Metabolome of Marine Myxobacteria Reveals High Potential for Biosynthesis of Novel Specialized Metabolites. PMID:30413766
The antiSMASH database version 2: a comprehensive resource on secondary metabolite biosynthetic gene clusters. PMID:30395294
Bacillus velezensis FZB42 in 2018: The Gram-Positive Model Strain for Plant Growth Promotion and Biocontrol. PMID:30386322
Short-chain ketone production by engineered polyketide synthases in Streptomyces albus. PMID:30385744
Activation of microbial secondary metabolic pathways: Avenues and challenges. PMID:30345402
Exploration of the Biosynthetic Potential of the Populus Microbiome. PMID:30320216
Emerging evolutionary paradigms in antibiotic discovery. PMID:30269177
Biosynthesis of the neurotoxin domoic acid in a bloom-forming diatom. PMID:30262498
Inter-Kingdom beach warfare: Microbial chemical communication activates natural chemical defences. PMID:30116041
Boosting Secondary Metabolite Production and Discovery through the Engineering of Novel Microbial Biosensors. PMID:30079350
Evolutionary freedom in the regulation of the conserved itaconate cluster by Ria1 in related Ustilaginaceae. PMID:30065845
Characterization of the Jomthonic Acids Biosynthesis Pathway and Isolation of Novel Analogues in Streptomyces caniferus GUA-06-05-006A. PMID:30065171
Antibiotic-induced acceleration of type 1 diabetes alters maturation of innate intestinal immunity. PMID:30039798
Bipartite interactions, antibiotic production and biosynthetic potential of the Arabidopsis leaf microbiome. PMID:30038309
The evolution of three siderophore biosynthetic clusters in environmental and host-associating strains of Pantoea. PMID:30027301
A standardized workflow for submitting data to the Minimum Information about a Biosynthetic Gene cluster (MIBiG) repository: prospects for research-based educational experiences. PMID:30008988
Cooperative Involvement of Glycosyltransferases in the Transfer of Amino Sugars during the Biosynthesis of the Macrolactam Sipanmycin by Streptomyces sp. Strain CS149. PMID:30006405
The value of universally available raw NMR data for transparency, reproducibility, and integrity in natural product research. PMID:30003207
Genome Sequencing and analyses of Two Marine Fungi from the North Sea Unraveled a Plethora of Novel Biosynthetic Gene Clusters. PMID:29976990
Whole genome comparison of Aspergillus flavus L-morphotype strain NRRL 3357 (type) and S-morphotype strain AF70. PMID:29966003
Evolution and Diversity of Biosynthetic Gene Clusters in Fusarium. PMID:29922257
An orthogonal system for heterologous expression of actinobacterial lasso peptides in Streptomyces hosts. PMID:29844351
Uncovering production of specialized metabolites by Streptomyces argillaceus: Activation of cryptic biosynthesis gene clusters using nutritional and genetic approaches. PMID:29795673
BAGEL4: a user-friendly web server to thoroughly mine RiPPs and bacteriocins. PMID:29788290
Chemoenzymatic Dissection of Polyketide β-Branching in the Bryostatin Pathway. PMID:29779653
Mining for Microbial Gems: Integrating Proteomics in the Postgenomic Natural Product Discovery Pipeline. PMID:29708658
HEx: A heterologous expression platform for the discovery of fungal natural products. PMID:29651464
Identification of the First Diketomorpholine Biosynthetic Pathway Using FAC-MS Technology. PMID:29631395
Comparative Genomics and Biosynthetic Potential Analysis of Two Lichen-Isolated Amycolatopsis Strains. PMID:29593664
Computational Genomics of Specialized Metabolism: from Natural Product Discovery to Microbiome Ecology. PMID:29556550
Analysis of the Pseudouridimycin Biosynthetic Pathway Provides Insights into the Formation of C-nucleoside Antibiotics. PMID:29551347
Interrogation of Benzomalvin Biosynthesis Using Fungal Artificial Chromosomes with Metabolomic Scoring (FAC-MS): Discovery of a Benzodiazepine Synthase Activity. PMID:29533658
The modules of trans-acyltransferase assembly lines redefined with a central acyl carrier protein. PMID:29524261
De novo design and engineering of non-ribosomal peptide synthetases. PMID:29461518
Diverse and Abundant Secondary Metabolism Biosynthetic Gene Clusters in the Genomes of Marine Sponge Derived Streptomyces spp. Isolates. PMID:29461500
Searching for Glycosylated Natural Products in Actinomycetes and Identification of Novel Macrolactams and Angucyclines. PMID:29441046
Identification of a biosynthetic gene cluster for the polyene macrolactam sceliphrolactam in a Streptomyces strain isolated from mangrove sediment. PMID:29371699
Increased diversity of peptidic natural products revealed by modification-tolerant database search of mass spectra. PMID:29358742
Engineered polyketides: Synergy between protein and host level engineering. PMID:29318196
Linking secondary metabolites to gene clusters through genome sequencing of six diverse Aspergillus species. PMID:29317534
Comparative transcriptomics as a guide to natural product discovery and biosynthetic gene cluster functionality. PMID:29229817
Diverse Cone-Snail Species Harbor Closely Related Streptomyces Species with Conserved Chemical and Genetic Profiles, Including Polycyclic Tetramic Acid Macrolactams. PMID:29225593
Warhead biosynthesis and the origin of structural diversity in hydroxamate metalloproteinase inhibitors. PMID:29213087
Coculture of Marine Invertebrate-Associated Bacteria and Interdisciplinary Technologies Enable Biosynthesis and Discovery of a New Antibiotic, Keyicin. PMID:29121465
Recent development of antiSMASH and other computational approaches to mine secondary metabolite biosynthetic gene clusters. PMID:29112695
NPASS: natural product activity and species source database for natural product research, discovery and tool development. PMID:29106619
Norine: A powerful resource for novel nonribosomal peptide discovery. PMID:29082924
Small Molecule Accurate Recognition Technology (SMART) to Enhance Natural Products Research. PMID:29079836
Development of fungal cell factories for the production of secondary metabolites: Linking genomics and metabolism. PMID:29062956
In silico methods for linking genes and secondary metabolites: The way forward. PMID:29062931
The secondary metabolite bioinformatics portal: Computational tools to facilitate synthetic biology of secondary metabolite production. PMID:29062930
Collaborating with Undergraduates To Contribute to Biochemistry Community Resources. PMID:29048882
ClusterCAD: a computational platform for type I modular polyketide synthase design. PMID:29040649
MicroScope-an integrated resource for community expertise of gene functions and comparative analysis of microbial genomic and metabolic data. PMID:28968784
Phenetic Comparison of Prokaryotic Genomes Using k-mers. PMID:28957508
A strategy for the identification of patterns in the biosynthesis of nonribosomal peptides by Betaproteobacteria species. PMID:28871139
Identification of Secondary Metabolite Gene Clusters in the Pseudovibrio Genus Reveals Encouraging Biosynthetic Potential toward the Production of Novel Bioactive Compounds. PMID:28868049
Current Status and Future Prospects of Marine Natural Products (MNPs) as Antimicrobials. PMID:28846659
Minimum information about a single amplified genome (MISAG) and a metagenome-assembled genome (MIMAG) of bacteria and archaea. PMID:28787424
Genomic insights into specialized metabolism in the marine actinomycete Salinispora. PMID:28752948
Genome-Wide Analysis of Secondary Metabolite Gene Clusters in Ophiostoma ulmi and Ophiostoma novo-ulmi Reveals a Fujikurin-Like Gene Cluster with a Putative Role in Infection. PMID:28659888
Cryptic indole hydroxylation by a non-canonical terpenoid cyclase parallels bacterial xenobiotic detoxification. PMID:28643772
Nonribosomal peptide synthetase biosynthetic clusters of ESKAPE pathogens. PMID:28642945
SANDPUMA: ensemble predictions of nonribosomal peptide chemistry reveal biosynthetic diversity across Actinobacteria. PMID:28633438
Uncovering the repertoire of fungal secondary metabolites: From Fleming's laboratory to the International Space Station. PMID:28632991
Nonomuraea sp. ATCC 55076 harbours the largest actinomycete chromosome to date and the kistamicin biosynthetic gene cluster. PMID:28626548
A scalable platform to identify fungal secondary metabolites and their gene clusters. PMID:28604695
Interpreting Microbial Biosynthesis in the Genomic Age: Biological and Practical Considerations. PMID:28587290
Symbiosis-inspired approaches to antibiotic discovery. PMID:28561849
Secondary metabolite genes encoded by potato rhizosphere microbiomes in the Andean highlands are diverse and vary with sampling site and vegetation stage. PMID:28539610
Harnessing plant metabolic diversity. PMID:28527344
RiPPMiner: a bioinformatics resource for deciphering chemical structures of RiPPs based on prediction of cleavage and cross-links. PMID:28499008
Digitizing mass spectrometry data to explore the chemical diversity and distribution of marine cyanobacteria and algae. PMID:28492366
The Antibiotic Resistant Target Seeker (ARTS), an exploration engine for antibiotic cluster prioritization and novel drug target discovery. PMID:28472505
antiSMASH 4.0-improvements in chemistry prediction and gene cluster boundary identification. PMID:28460038
SeMPI: a genome-based secondary metabolite prediction and identification web server. PMID:28453782
plantiSMASH: automated identification, annotation and expression analysis of plant biosynthetic gene clusters. PMID:28453650
The Uncommon Enzymology of Cis-Acyltransferase Assembly Lines. PMID:28394118
Aspergillus hancockii sp. nov., a biosynthetically talented fungus endemic to southeastern Australian soils. PMID:28379953
Polyketide Synthase Modules Redefined. PMID:28322495
Using natural products for drug discovery: the impact of the genomics era. PMID:28277838
Ribosomally synthesized and post-translationally modified peptide natural product discovery in the genomic era. PMID:28260651
A new genome-mining tool redefines the lasso peptide biosynthetic landscape. PMID:28244986
Identification by Genome Mining of a Type I Polyketide Gene Cluster from Streptomyces argillaceus Involved in the Biosynthesis of Pyridine and Piperidine Alkaloids Argimycins P. PMID:28239372
-Genomic data mining of the marine actinobacteria Streptomyces sp. H-KF8 unveils insights into multi-stress related genes and metabolic pathways involved in antimicrobial synthesis. PMID:28229018
Resequencing and annotation of the Nostoc punctiforme ATTC 29133 genome: facilitating biofuel and high-value chemical production. PMID:28211005
Bacillus amyloliquefaciens, Bacillus velezensis, and Bacillus siamensis Form an "Operational Group B. amyloliquefaciens" within the B. subtilis Species Complex. PMID:28163698
Discovery of C-Glycosylpyranonaphthoquinones in Streptomyces sp. MBT76 by a Combined NMR-Based Metabolomics and Bioinformatics Workflow. PMID:28128554
Assessing in silico the recruitment and functional spectrum of bacterial enzymes from secondary metabolism. PMID:28125959
From a Natural Product to Its Biosynthetic Gene Cluster: A Demonstration Using Polyketomycin from Streptomyces diastatochromogenes Tü6028. PMID:28117820
The antiSMASH database, a comprehensive database of microbial secondary metabolite biosynthetic gene clusters. PMID:27924032
Sequencing rare marine actinomycete genomes reveals high density of unique natural product biosynthetic gene clusters. PMID:27902408
MicroScope in 2017: an expanding and evolving integrated resource for community expertise of microbial genomes. PMID:27899624
Natural products as mediators of disease. PMID:27874907
Dereplication of peptidic natural products through database search of mass spectra. PMID:27820803
Secondary metabolite gene clusters in the entomopathogen fungus Metarhizium anisopliae: genome identification and patterns of expression in a cuticle infection model. PMID:27801295
Indexing the Pseudomonas specialized metabolome enabled the discovery of poaeamide B and the bananamides. PMID:27798598
MIxS-HCR: a MIxS extension defining a minimal information standard for sequence data from environments pertaining to hydrocarbon resources. PMID:27777648
Genomic charting of ribosomally synthesized natural product chemical space facilitates targeted mining. PMID:27698135
Polyketide and nonribosomal peptide retro-biosynthesis and global gene cluster matching. PMID:27694801
Synthetic Biology of Natural Products. PMID:27503995
Natural Products and the Gene Cluster Revolution. PMID:27491886
Antibiotic drug discovery. PMID:27470984
Marine-derived myxobacteria of the suborder Nannocystineae: An underexplored source of structurally intriguing and biologically active metabolites. PMID:27340488
Computational genomic identification and functional reconstitution of plant natural product biosynthetic pathways. PMID:27321668
Standardization for natural product synthetic biology. PMID:27313083
Phylogenomic Analysis of Natural Products Biosynthetic Gene Clusters Allows Discovery of Arseno-Organic Metabolites in Model Streptomycetes. PMID:27289100
The Prehistory of Antibiotic Resistance. PMID:27252395
Biological characterization of the hygrobafilomycin antibiotic JBIR-100 and bioinformatic insights into the hygrolide family of natural products. PMID:27234886
Bioengineering microbial communities: Their potential to help, hinder and disgust. PMID:27221461
Biogenesis of antibiotics-viewing its history and glimpses of the future. PMID:27188629
Plant metabolic clusters - from genetics to genomics. PMID:27112429
Next Generation Sequencing of Actinobacteria for the Discovery of Novel Natural Products. PMID:27089350
Accessing Nature's diversity through metabolic engineering and synthetic biology. PMID:27081481
Metabolomics-guided analysis of isocoumarin production by Streptomyces species MBT76 and biotransformation of flavonoids and phenylpropanoids. PMID:27073352
Characterization and engineering of the biosynthesis gene cluster for antitumor macrolides PM100117 and PM100118 from a marine actinobacteria: generation of a novel improved derivative. PMID:26905289
Delineation of metabolic gene clusters in plant genomes by chromatin signatures. PMID:26895889
Bacteriocins of lactic acid bacteria: extending the family. PMID:26860942
Assembly and clustering of natural antibiotics guides target identification. PMID:26829473
Comprehensive curation and analysis of fungal biosynthetic gene clusters of published natural products. PMID:26808821
Genome sequencing and secondary metabolism of the postharvest pathogen Penicillium griseofulvum. PMID:26729047
Novel Routes for Improving Biocontrol Activity of Bacillus Based Bioinoculants. PMID:26696998
Synthetic biology for pharmaceutical drug discovery. PMID:26673570
StreptomeDB 2.0--an extended resource of natural products produced by streptomycetes. PMID:26615197
Direct Capture Technologies for Genomics-Guided Discovery of Natural Products. PMID:26456469
Identification and activation of novel biosynthetic gene clusters by genome mining in the kirromycin producer Streptomyces collinus Tü 365. PMID:26433383 -
MIBiG 2.0: a repository for biosynthetic gene clusters of known function
PubMed citations: 134.
134 articles citing: MIBiG 2.0: a repository for biosynthetic gene clusters of known function
BioCAT: Search for biosynthetic gene clusters producing nonribosomal peptides with known structure. PMID:35317229
Strategies to access biosynthetic novelty in bacterial genomes for drug discovery. PMID:35296832
Co-elicitation of lignocelluloytic enzymatic activities and metabolites production in an Aspergillus-Streptomyces co-culture during lignocellulose fractionation. PMID:35243445
Genome sequence data of Bacillus velezensis BP1.2A and BT2.4. PMID:35242952
Unveiling the genomic potential of Pseudomonas type strains for discovering new natural products. PMID:35195510
A bacterial endosymbiont of the fungus Rhizopus microsporus drives phagocyte evasion and opportunistic virulence. PMID:35134329
Microorganisms harbor keys to a circular bioeconomy making them useful tools in fighting plastic pollution and rising CO2 levels. PMID:35118556
Biosynthetic Potential of the Endophytic Fungus Helotiales sp. BL73 Revealed via Compound Identification and Genome Mining. PMID:35108081
Isolation and characterization of Streptomyces bacteriophages and Streptomyces strains encoding biosynthetic arsenals. PMID:35061755
The virulome of Streptomyces scabiei in response to cello-oligosaccharide elicitors. PMID:35040428
The natural product biosynthesis potential of the microbiomes of Earth - Bioprospecting for novel anti-microbial agents in the meta-omics era. PMID:35035787
Habitat Adaptation Drives Speciation of a Streptomyces Species with Distinct Habitats and Disparate Geographic Origins. PMID:35012331
Bioinformatic and Mechanistic Analysis of the Palmerolide PKS-NRPS Biosynthetic Pathway From the Microbiome of an Antarctic Ascidian. PMID:35004620
Generating lineage-resolved, complete metagenome-assembled genomes from complex microbial communities. PMID:34980911
An isotopic labeling approach linking natural products with biosynthetic gene clusters. PMID:34969972
Identification of structurally diverse menaquinone-binding antibiotics with in vivo activity against multidrug-resistant pathogens. PMID:34949828
Re-classification of Streptomyces venezuelae strains and mining secondary metabolite biosynthetic gene clusters. PMID:34877485
New Kendomycin Derivative Isolated from Streptomyces sp. Cl 58-27. PMID:34833926
The Methods of Digging for "Gold" within the Salt: Characterization of Halophilic Prokaryotes and Identification of Their Valuable Biological Products Using Sequencing and Genome Mining Tools. PMID:34828362
Complete Genome Sequence of Two Deep-Sea Streptomyces Isolates from Madeira Archipelago and Evaluation of Their Biosynthetic Potential. PMID:34822492
Advances in decomposing complex metabolite mixtures using substructure- and network-based computational metabolomics approaches. PMID:34821250
A roadmap for metagenomic enzyme discovery. PMID:34821235
Genome-Guided Discovery of Natural Products through Multiplexed Low-Coverage Whole-Genome Sequencing of Soil Actinomycetes on Oxford Nanopore Flongle. PMID:34812649
Long-read metagenomics of soil communities reveals phylum-specific secondary metabolite dynamics. PMID:34795375
Pan-genome analysis identifies intersecting roles for Pseudomonas specialized metabolites in potato pathogen inhibition. PMID:34792466
Activation and Identification of a Griseusin Cluster in Streptomyces sp. CA-256286 by Employing Transcriptional Regulators and Multi-Omics Methods. PMID:34770989
Synthaser: a CD-Search enabled Python toolkit for analysing domain architecture of fungal secondary metabolite megasynth(et)ases. PMID:34763725
Genome analysis suggests the bacterial family Acetobacteraceae is a source of undiscovered specialized metabolites. PMID:34761294
Flavobacterium flabelliforme sp. nov. and Flavobacterium geliluteum sp. nov., Two Multidrug-Resistant Psychrotrophic Species Isolated From Antarctica. PMID:34745033
Mapping the catalytic conformations of an assembly-line polyketide synthase module. PMID:34735239
The Natural Products Atlas 2.0: a database of microbially-derived natural products. PMID:34718710
ARTS-DB: a database for antibiotic resistant targets. PMID:34718689
Adaptation to Endophytic Lifestyle Through Genome Reduction by Kitasatospora sp. SUK42. PMID:34712653
Biogeography of Bacterial Communities and Specialized Metabolism in Human Aerodigestive Tract Microbiomes. PMID:34704787
Live Biosensors for Ultrahigh-Throughput Screening of Antimicrobial Activity against Gram-Negative Bacteria. PMID:34680742
Depside and Depsidone Synthesis in Lichenized Fungi Comes into Focus through a Genome-Wide Comparison of the Olivetoric Acid and Physodic Acid Chemotypes of Pseudevernia furfuracea. PMID:34680078
Nerpa: A Tool for Discovering Biosynthetic Gene Clusters of Bacterial Nonribosomal Peptides. PMID:34677408
Colibrimycins, Novel Halogenated Hybrid Polyketide Synthase-Nonribosomal Peptide Synthetase (PKS-NRPS) Compounds Produced by Streptomyces sp. Strain CS147. PMID:34669429
NPClassifier: A Deep Neural Network-Based Structural Classification Tool for Natural Products. PMID:34662515
Pan-Genome of the Genus Streptomyces and Prioritization of Biosynthetic Gene Clusters With Potential to Produce Antibiotic Compounds. PMID:34659136
Metagenomic Sequencing of Multiple Soil Horizons and Sites in Close Vicinity Revealed Novel Secondary Metabolite Diversity. PMID:34636675
Advancements in capturing and mining mass spectrometry data are transforming natural products research. PMID:34612288
Evaluating the Distribution of Bacterial Natural Product Biosynthetic Genes across Lake Huron Sediment. PMID:34605624
Applications and Restrictions of Integrated Genomic and Metabolomic Screening: An Accelerator for Drug Discovery from Actinomycetes? PMID:34576921
Genome Analysis of Streptomyces nojiriensis JCM 3382 and Distribution of Gene Clusters for Three Antibiotics and an Azasugar across the Genus Streptomyces. PMID:34576698
FunOrder: A robust and semi-automated method for the identification of essential biosynthetic genes through computational molecular co-evolution. PMID:34570757
Mass spectrometry-based metabolomics in microbiome investigations. PMID:34552265
Culture and genome-based analysis of four soil Clostridium isolates reveal their potential for antimicrobial production. PMID:34548019
Chromosome-Level Genome Sequence of Aspergillus chevalieri M1, Isolated from Katsuobushi. PMID:34528823
Secondary metabolite biosynthetic diversity in the fungal family Hypoxylaceae and Xylaria hypoxylon. PMID:34527085
Integrating perspectives in actinomycete research: an ActinoBase review of 2020-21. PMID:34515628
Chromosome-Level Genome Sequence of Aspergillus puulaauensis MK2, a Fungus Isolated from a Dead Hard Tick. PMID:34498921
Comparative Genomics Reveals a Remarkable Biosynthetic Potential of the Streptomyces Phylogenetic Lineage Associated with Rugose-Ornamented Spores. PMID:34427515
Comprehensive Large-Scale Integrative Analysis of Omics Data To Accelerate Specialized Metabolite Discovery. PMID:34427506
Towards the sustainable discovery and development of new antibiotics. PMID:34426795
Chromosome-Level Genome Sequence of the Black Koji Fungus Aspergillus luchuensis RIB2601. PMID:34292062
Biosynthetic potential of uncultured Antarctic soil bacteria revealed through long-read metagenomic sequencing. PMID:34253854
Rhodococcus comparative genomics reveals a phylogenomic-dependent non-ribosomal peptide synthetase distribution: insights into biosynthetic gene cluster connection to an orphan metabolite. PMID:34241590
An Integrated Approach to Determine the Boundaries of the Azaphilone Pigment Biosynthetic Gene Cluster of Monascus ruber M7 Grown on Potato Dextrose Agar. PMID:34220766
Microbial Communities of Cladonia Lichens and Their Biosynthetic Gene Clusters Potentially Encoding Natural Products. PMID:34206222
Assessment of Evolutionary Relationships for Prioritization of Myxobacteria for Natural Product Discovery. PMID:34202719
Dissecting Disease-Suppressive Rhizosphere Microbiomes by Functional Amplicon Sequencing and 10× Metagenomics. PMID:34100635
Co-occurrence of enzyme domains guides the discovery of an oxazolone synthetase. PMID:34099916
Complete genome sequence of Streptomyces cyanogenus S136, producer of anticancer angucycline landomycin A. PMID:34094801
Leveraging Microbial Genomes and Genomic Context for Chemical Discovery. PMID:34087065
Synthetic biology approaches to actinomycete strain improvement. PMID:34057181
Integrating genomics and metabolomics for scalable non-ribosomal peptide discovery. PMID:34050176
A Machine Learning Bioinformatics Method to Predict Biological Activity from Biosynthetic Gene Clusters. PMID:34042443
Synergizing the potential of bacterial genomics and metabolomics to find novel antibiotics. PMID:33995996
Global Genome Mining Reveals the Distribution of Diverse Thioamidated RiPP Biosynthesis Gene Clusters. PMID:33995295
Phylogenetic analysis of the salinipostin γ-butyrolactone gene cluster uncovers new potential for bacterial signalling-molecule diversity. PMID:33979276
antiSMASH 6.0: improving cluster detection and comparison capabilities. PMID:33978755
Accessory Chromosome-Acquired Secondary Metabolism in Plant Pathogenic Fungi: The Evolution of Biotrophs Into Host-Specific Pathogens. PMID:33968000
Structures of a non-ribosomal peptide synthetase condensation domain suggest the basis of substrate selectivity. PMID:33947858
Ranking microbial metabolomic and genomic links in the NPLinker framework using complementary scoring functions. PMID:33945539
Heterologous production of cyanobacterial compounds. PMID:33928376
Recent Advances in Discovery of Lead Structures from Microbial Natural Products: Genomics- and Metabolomics-Guided Acceleration. PMID:33925414
Biosynthesis and Heterologous Expression of Cacaoidin, the First Member of the Lanthidin Family of RiPPs. PMID:33917820
Evolutionary and functional analysis of an NRPS condensation domain integrates β-lactam, ᴅ-amino acid, and dehydroamino acid synthesis. PMID:33893237
Insights into modular polyketide synthase loops aided by repetitive sequences. PMID:33843112
The rumen eukaryotome is a source of novel antimicrobial peptides with therapeutic potential. PMID:33832427
Coupling Mass Spectral and Genomic Information to Improve Bacterial Natural Product Discovery Workflows. PMID:33807702
Taxogenomic and Comparative Genomic Analysis of the Genus Saccharomonospora Focused on the Identification of Biosynthetic Clusters PKS and NRPS. PMID:33776952
Metagenomic insights into the taxonomy, function, and dysbiosis of prokaryotic communities in octocorals. PMID:33766108
Comparative genome analyses suggest a hemibiotrophic lifestyle and virulence differences for the beech bark disease fungal pathogens Neonectria faginata and Neonectria coccinea. PMID:33693679
Comparative Genomics Reveals Prophylactic and Catabolic Capabilities of Actinobacteria within the Fungus-Farming Termite Symbiosis. PMID:33658277
Genome-Driven Discovery of Enzymes with Industrial Implications from the Genus Aneurinibacillus. PMID:33652876
Whole genome sequencing of Streptomyces actuosus ISP-5337, Streptomyces sioyaensis B-5408, and Actinospica acidiphila B-2296 reveals secondary metabolomes with antibiotic potential. PMID:33643857
Automatic reconstruction of metabolic pathways from identified biosynthetic gene clusters. PMID:33622234
Addressing uncertainty in genome-scale metabolic model reconstruction and analysis. PMID:33602294
A community resource for paired genomic and metabolomic data mining. PMID:33589842
TOUCAN: a framework for fungal biosynthetic gene cluster discovery. PMID:33575642
Expression of fungal biosynthetic gene clusters in S. cerevisiae for natural product discovery. PMID:33553706
Genome Mining and Characterization of Biosynthetic Gene Clusters in Two Cave Strains of Paenibacillus sp. PMID:33505378
Planomonospora: A Metabolomics Perspective on an Underexplored Actinobacteria Genus. PMID:33496580
The Landscape of Recombination Events That Create Nonribosomal Peptide Diversity. PMID:33480992
Genome-based engineering of ligninolytic enzymes in fungi. PMID:33478513
Refactoring biosynthetic gene clusters for heterologous production of microbial natural products. PMID:33476936
CRISPR-based transcriptional activation tool for silent genes in filamentous fungi. PMID:33441979
BiG-SLiCE: A highly scalable tool maps the diversity of 1.2 million biosynthetic gene clusters. PMID:33438731
Draft Genome Sequence and Secondary Metabolite Biosynthetic Potential of the Lysobacter niastensis Type Strain DSM 18481. PMID:33414313
Antimicrobial activity screening of rhizosphere soil bacteria from tomato and genome-based analysis of their antimicrobial biosynthetic potential. PMID:33413100
Anti-Inflammatory, Antioxidant, and Wound-Healing Properties of Cyanobacteria from Thermal Mud of Balaruc-Les-Bains, France: A Multi-Approach Study. PMID:33383796
SeMPI 2.0-A Web Server for PKS and NRPS Predictions Combined with Metabolite Screening in Natural Product Databases. PMID:33383692
Elucidating the Diversity and Potential Function of Nonribosomal Peptide and Polyketide Biosynthetic Gene Clusters in the Root Microbiome. PMID:33361322
Transporter genes in biosynthetic gene clusters predict metabolite characteristics and siderophore activity. PMID:33361114
Expansion of RiPP biosynthetic space through integration of pan-genomics and machine learning uncovers a novel class of lanthipeptides. PMID:33351797
Comparative Genomics Analysis Provides New Strategies for Bacteriostatic Ability of Bacillus velezensis HAB-2. PMID:33281792
Draft Genome Sequence of the Toxic Freshwater Microcystis aeruginosa Strain PMC 728.11 (Cyanobacteria, Chroococcales). PMID:33239466
Streptomyces buecherae sp. nov., an actinomycete isolated from multiple bat species. PMID:33200278
A genomic catalog of Earth's microbiomes. PMID:33169036
The antiSMASH database version 3: increased taxonomic coverage and new query features for modular enzymes. PMID:33152079
The LnmK Bifunctional Acyltransferase/Decarboxylase Specifying (2R)-Methylmalonyl-CoA and Employing Substrate-Assisted Catalysis for Polyketide Biosynthesis. PMID:33095002
Genome Mining of the Genus Streptacidiphilus for Biosynthetic and Biodegradation Potential. PMID:33022985
BiG-FAM: the biosynthetic gene cluster families database. PMID:33010170
Beyond Toxin Transport: Novel Role of ABC Transporter for Enzymatic Machinery of Cereulide NRPS Assembly Line. PMID:32994334
Microbial natural product databases: moving forward in the multi-omics era. PMID:32856641
Global analysis of adenylate-forming enzymes reveals β-lactone biosynthesis pathway in pathogenic Nocardia. PMID:32826316
Genome Sequence of Trichoderma lixii MUT3171, A Promising Strain for Mycoremediation of PAH-Contaminated Sites. PMID:32825267
Variation Among Biosynthetic Gene Clusters, Secondary Metabolite Profiles, and Cards of Virulence Across Aspergillus Species. PMID:32817009
Viennamycins: Lipopeptides Produced by a Streptomyces sp. PMID:32786880
Comparative Genomics Discloses the Uniqueness and the Biosynthetic Potential of the Marine Cyanobacterium Hyella patelloides. PMID:32774329
Genome mining strategies for ribosomally synthesised and post-translationally modified peptides. PMID:32728407
The need to innovate sample collection and library generation in microbial drug discovery: a focus on academia. PMID:32706349
Diversity of Polyketide Synthases and Nonribosomal Peptide Synthetases Revealed Through Metagenomic Analysis of a Deep Oligotrophic Cave. PMID:32638044
Challenges and advances in genome mining of ribosomally synthesized and post-translationally modified peptides (RiPPs). PMID:32637669
Bioprospecting Through Cloning of Whole Natural Product Biosynthetic Gene Clusters. PMID:32582659
Draft Genome Sequence and Biosynthetic Potential of the Newly Described Strain Longimicrobium terrae CB-286315T. PMID:32527779
Identification, cloning and heterologous expression of biosynthetic gene cluster for desertomycin. PMID:32457441
ARTS 2.0: feature updates and expansion of the Antibiotic Resistant Target Seeker for comparative genome mining. PMID:32427317
Recent Advances in Strategies for Activation and Discovery/Characterization of Cryptic Biosynthetic Gene Clusters in Streptomyces. PMID:32344564
Translation-Targeting RiPPs and Where to Find Them. PMID:32296456
Diversity of Secondary Metabolism in Aspergillus nidulans Clinical Isolates. PMID:32269157
Isolation, Genomic and Metabolomic Characterization of Streptomyces tendae VITAKN with Quorum Sensing Inhibitory Activity from Southern India. PMID:31963137
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pathway model
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microbial ecology
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metabolomics
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small molecules
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metagenomics
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drug discovery
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More detailed information about this field from each metasource.
enzyme
metasource: Fairsharing.orgversion: FAIRsharing.org: MIBiG; Minimum Information about a Biosynthetic Gene cluster; DOI: https://doi.org/10.25504/FAIRsharing.jqfgxs; Last edited: May 20, 2021, 2:03 p.m.; Last accessed: Jan 03 2022 7:12 p.m.
metabolite
metasource: Fairsharing.orgversion: FAIRsharing.org: MIBiG; Minimum Information about a Biosynthetic Gene cluster; DOI: https://doi.org/10.25504/FAIRsharing.jqfgxs; Last edited: May 20, 2021, 2:03 p.m.; Last accessed: Jan 03 2022 7:12 p.m.
pathway model
metasource: Fairsharing.orgversion: FAIRsharing.org: MIBiG; Minimum Information about a Biosynthetic Gene cluster; DOI: https://doi.org/10.25504/FAIRsharing.jqfgxs; Last edited: May 20, 2021, 2:03 p.m.; Last accessed: Jan 03 2022 7:12 p.m.
sequence cluster
metasource: Fairsharing.orgversion: FAIRsharing.org: MIBiG; Minimum Information about a Biosynthetic Gene cluster; DOI: https://doi.org/10.25504/FAIRsharing.jqfgxs; Last edited: May 20, 2021, 2:03 p.m.; Last accessed: Jan 03 2022 7:12 p.m.
microbial ecology
metasource: bio.toolsversion: extracted_at: 2022-11-04T11:29:23.808068
metabolomics
metasource: bio.toolsversion: extracted_at: 2022-11-04T11:29:23.808068
small molecules
metasource: bio.toolsversion: extracted_at: 2022-11-04T11:29:23.808068
metagenomics
metasource: bio.toolsversion: extracted_at: 2022-11-04T11:29:23.808068
drug discovery
metasource: bio.toolsversion: extracted_at: 2022-11-04T11:29:23.808068
enzyme metabolite pathway model sequence cluster microbial ecology metabolomics small molecule metagenomics drug discovery
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