ACTIVITY

ACTIVITY, a database on DNA site sequences with known activity magnitudes, measurement systems and sequence-activity relationships under fixed experimental conditions is additionally adapted to applications to the phylogenetic footprints of known sites. To this aim, we have created three resources, ACTIVITY_Reports, ACTIVITY_Tuning, and TFsite_Annotations. For a given site with known sequence-activity relationships, the first database ACTIVITY_Reports accumulates the quantitative data on the impact of the site surrounding, which allows for correct recognition of this site. From this way characterized site-surrounding relationships, the Java applet aimed at precise analysis of phylogenetic footprints of only this known site is automatically generated and stored within the knowledge base ACTIVITY_Tuning. Next, the resulting database TFsite_Annotations documents the Java applet results obtained in the cases of only putative sites of the same type and the same location within the same regulatory region of the homologous gene. The resources enriching the current ACTIVITY release are available at URL=http://util.bionet.nsc.ru/databases/activity.html.

Webpage:
http://wwwmgs.bionet.nsc.ru/mgs/systems/activity/

Tags:

nucleic acid sequence transcription

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