Crystals of TELSAM-target protein fusions that exhibit minimal crystal contacts and lack direct inter-TELSAM contacts.
PMID:35232248
Analysis of 11,430 recombinant protein production experiments reveals that protein yield is tunable by synonymous codon changes of translation initiation sites.
PMID:34610008
From Genome to Drugs: New Approaches in Antimicrobial Discovery.
PMID:34177572
Structural genomics and the Protein Data Bank.
PMID:33957120
TISIGNER.com: web services for improving recombinant protein production.
PMID:33744969
Solubility-Weighted Index: fast and accurate prediction of protein solubility.
PMID:32559287
Establishing synthesis pathway-host compatibility via enzyme solubility.
PMID:30802311
The TMCrys server for supporting crystallization of transmembrane proteins.
PMID:30793168
TMCrys: predict propensity of success for transmembrane protein crystallization.
PMID:29718100
A statistical model for improved membrane protein expression using sequence-derived features.
PMID:29378850
Target-Pathogen: a structural bioinformatic approach to prioritize drug targets in pathogens.
PMID:29106651
Survey of Predictors of Propensity for Protein Production and Crystallization with Application to Predict Resolution of Crystal Structures.
PMID:28933304
The "Sticky Patch" Model of Crystallization and Modification of Proteins for Enhanced Crystallizability.
PMID:28573570
Critical evaluation of bioinformatics tools for the prediction of protein crystallization propensity.
PMID:28334201
TSTMP: target selection for structural genomics of human transmembrane proteins.
PMID:27924015
A pipeline for structure determination of in vivo-grown crystals using in cellulo diffraction.
PMID:27050136
PAT: predictor for structured units and its application for the optimization of target molecules for the generation of synthetic antibodies.
PMID:27039071
The impact of structural genomics: the first quindecennial.
PMID:26935210
Computational crystallization.
PMID:26792536
Predicting Crystallization Propensity of Proteins from Arabidopsis Thaliana.
PMID:26604856
Analysis of crystallization data in the Protein Data Bank.
PMID:26457511
JPred4: a protein secondary structure prediction server.
PMID:25883141
The accurate assessment of small-angle X-ray scattering data.
PMID:25615859
Protein structure annotation resources.
PMID:25502191
Covering complete proteomes with X-ray structures: a current snapshot.
PMID:25372670
PredPPCrys: accurate prediction of sequence cloning, protein production, purification and crystallization propensity from protein sequences using multi-step heterogeneous feature fusion and selection.
PMID:25148528
Statistical analysis of crystallization database links protein physico-chemical features with crystallization mechanisms.
PMID:24988076
A review of machine learning methods to predict the solubility of overexpressed recombinant proteins in Escherichia coli.
PMID:24885721
Improving the chances of successful protein structure determination with a random forest classifier.
PMID:24598732
Selecting targets from eukaryotic parasites for structural genomics and drug discovery.
PMID:24590708
Data management in the modern structural biology and biomedical research environment.
PMID:24590705
Soluble expression of proteins correlates with a lack of positively-charged surface.
PMID:24276756
Quantification of the impact of PSI:Biology according to the annotations of the determined structures.
PMID:24139526
Discrimination of soluble and aggregation-prone proteins based on sequence information.
PMID:23440081
Utilization of protein intrinsic disorder knowledge in structural proteomics.
PMID:23232152
Assessing the accuracy of template-based structure prediction metaservers by comparison with structural genomics structures.
PMID:23086054
PROSPERO: online prediction of crystallographic success from experimental results and sequence.
PMID:22675232
High-throughput characterization of intrinsic disorder in proteins from the Protein Structure Initiative.
PMID:22651963
Lessons from high-throughput protein crystallization screening: 10 years of practical experience.
PMID:22646073
Structural genomics plucks high-hanging membrane proteins.
PMID:22622032
Large-scale experimental studies show unexpected amino acid effects on protein expression and solubility in vivo in E. coli.
PMID:22587847
Crystal structures of putative phosphoglycerate kinases from B. anthracis and C. jejuni.
PMID:22403005
Target selection for structural genomics based on combining fold recognition and crystallisation prediction methods: application to the human proteome.
PMID:22354707
Automated protein structure modeling with SWISS-MODEL Workspace and the Protein Model Portal.
PMID:22323219
Sequence-based classification using discriminatory motif feature selection.
PMID:22102890
Computational approaches to selecting and optimising targets for structural biology.
PMID:21906678
Sequence-based prediction of protein crystallization, purification and production propensity.
PMID:21685077
What's in a drop? Correlating observations and outcomes to guide macromolecular crystallization experiments.
PMID:21643490
Recording information on protein complexes in an information management system.
PMID:21605682
The Structural Biology Knowledgebase: a portal to protein structures, sequences, functions, and methods.
PMID:21472436
Small angle X-ray scattering as a complementary tool for high-throughput structural studies.
PMID:21462184
The Protein Information Management System (PiMS): a generic tool for any structural biology research laboratory.
PMID:21460443
Preparation of protein samples for NMR structure, function, and small-molecule screening studies.
PMID:21371586
PSI:Biology-materials repository: a biologist's resource for protein expression plasmids.
PMID:21360289
XANNpred: neural nets that predict the propensity of a protein to yield diffraction-quality crystals.
PMID:21246630
The structure of SSO2064, the first representative of Pfam family PF01796, reveals a novel two-domain zinc-ribbon OB-fold architecture with a potential acyl-CoA-binding role.
PMID:20944206
Disease risk of missense mutations using structural inference from predicted function.
PMID:20887259
A protein sequence meta-functional signature for calcium binding residue prediction.
PMID:20824111
TOPSAN: a collaborative annotation environment for structural genomics.
PMID:20716366
Learning to predict expression efficacy of vectors in recombinant protein production.
PMID:20122193
The crystal structure and activity of a putative trypanosomal nucleoside phosphorylase reveal it to be a homodimeric uridine phosphorylase.
PMID:20070944
Protein Structure Initiative Material Repository: an open shared public resource of structural genomics plasmids for the biological community.
PMID:19906724
CRYSTALP2: sequence-based protein crystallization propensity prediction.
PMID:19646256
Benefits of structural genomics for drug discovery research.
PMID:19594422
Structural genomics is the largest contributor of novel structural leverage.
PMID:19194785
Case-controlled structure validation.
PMID:19171969
Automated protein structure calculation from NMR data.
PMID:19137264
Data deposition and annotation at the worldwide protein data bank.
PMID:19082769
Understanding the physical properties that control protein crystallization by analysis of large-scale experimental data.
PMID:19079241
The protein structure initiative structural genomics knowledgebase.
PMID:19010965
Genome pool strategy for structural coverage of protein families.
PMID:19000818
The FEATURE framework for protein function annotation: modeling new functions, improving performance, and extending to novel applications.
PMID:18831785
The Jpred 3 secondary structure prediction server.
PMID:18463136
TarO: a target optimisation system for structural biology.
PMID:18385152
A graphical approach to tracking and reporting target status in structural genomics.
PMID:18236171
The SeqFEATURE library of 3D functional site models: comparison to existing methods and applications to protein function annotation.
PMID:18197987
Polymer-driven crystallization.
PMID:17962407
The challenge of protein structure determination--lessons from structural genomics.
PMID:17962404
Structural genomics: keeping up with expanding knowledge of the protein universe.
PMID:17587562
StrBioLib: a Java library for development of custom computational structural biology applications.
PMID:17537750
Growth of novel protein structural data.
PMID:17360626
Towards fully automated structure-based function prediction in structural genomics: a case study.
PMID:17316683
WormBase: new content and better access.
PMID:17099234
A fast SCOP fold classification system using content-based E-Predict algorithm.
PMID:16872501
Structural proteomics of minimal organisms: conservation of protein fold usage and evolutionary implications.
PMID:16566839
PDB-UF: database of predicted enzymatic functions for unannotated protein structures from structural genomics.
PMID:16460560
The RCSB PDB information portal for structural genomics.
PMID:16381872
PubNet: a flexible system for visualizing literature derived networks.
PMID:16168087
Functional coverage of the human genome by existing structures, structural genomics targets, and homology models.
PMID:16118666
Pilot studies on the parallel production of soluble mouse proteins in a bacterial expression system.
PMID:15965734
The RCSB Protein Data Bank: a redesigned query system and relational database based on the mmCIF schema.
PMID:15608185