Open Targets
Names
More detailed information about this field from each metasource.
Open Targets
metasource: Fairsharing.org
version: FAIRsharing.org: Open Targets; Open Targets; DOI: https://doi.org/10.25504/FAIRsharing.3f9n4y; Last edited: June 16, 2021, 1:17 p.m.; Last accessed: Jan 03 2022 7:06 p.m.
metasource: Nucleic Acid Research database catalogue
version: extracted_at: 2022-11-04T11:16:25.468657
metasource: BiŌkeanós-Medsourcing
version: 0.0.1:2022-11-04T13:34:25.975929
Open Targets Platform
metasource: bio.tools
version: extracted_at: 2022-11-04T11:25:09.130710
Open_Targets_Platform
metasource: bio.tools
version: extracted_at: 2022-11-04T11:25:09.130710
Names
More detailed information about this field from each metasource.
Open Targets
metasource: Fairsharing.orgversion: FAIRsharing.org: Open Targets; Open Targets; DOI: https://doi.org/10.25504/FAIRsharing.3f9n4y; Last edited: June 16, 2021, 1:17 p.m.; Last accessed: Jan 03 2022 7:06 p.m.
metasource: Nucleic Acid Research database catalogue
version: extracted_at: 2022-11-04T11:16:25.468657
metasource: BiŌkeanós-Medsourcing
version: 0.0.1:2022-11-04T13:34:25.975929
Open Targets Platform
metasource: bio.toolsversion: extracted_at: 2022-11-04T11:25:09.130710
Open_Targets_Platform
metasource: bio.toolsversion: extracted_at: 2022-11-04T11:25:09.130710
Other names: Open Targets Platform, Open_Targets_Platform
Names
More detailed information about this field from each metasource.
Open Targets
metasource: Fairsharing.orgversion: FAIRsharing.org: Open Targets; Open Targets; DOI: https://doi.org/10.25504/FAIRsharing.3f9n4y; Last edited: June 16, 2021, 1:17 p.m.; Last accessed: Jan 03 2022 7:06 p.m.
metasource: Nucleic Acid Research database catalogue
version: extracted_at: 2022-11-04T11:16:25.468657
metasource: BiŌkeanós-Medsourcing
version: 0.0.1:2022-11-04T13:34:25.975929
Open Targets Platform
metasource: bio.toolsversion: extracted_at: 2022-11-04T11:25:09.130710
Open_Targets_Platform
metasource: bio.toolsversion: extracted_at: 2022-11-04T11:25:09.130710
The Open Targets Platform is a comprehensive and robust data integration for access to and visualisation of potential drug targets associated with disease. It brings together multiple data types and aims to assist users to identify and prioritise targets for further investigation. The Platform supports workflows starting from a target or disease, and shows the available evidence for target – disease associations. Target and Disease profile pages showing specific information for both target (e.g baseline expression) and disease (e.g. Disease Classification) are also available.
Description
More detailed information about this field from each metasource.
The Open Targets Platform is a comprehensive and robust data integration for access to and visualisation of potential drug targets associated with disease. It brings together multiple data types and aims to assist users to identify and prioritise targets for further investigation. The Platform supports workflows starting from a target or disease, and shows the available evidence for target – disease associations. Target and Disease profile pages showing specific information for both target (e.g baseline expression) and disease (e.g. Disease Classification) are also available.
metasource: BiŌkeanós-Medsourcingversion: 0.0.1:2022-11-04T13:34:25.975929
Open Targets is a data integration platform for access to and visualisation of potential drug targets associated with disease. Each drug target is linked to a disease using integrated genome-wide data from a broad range of data sources.
metasource: Fairsharing.orgversion: FAIRsharing.org: Open Targets; Open Targets; DOI: https://doi.org/10.25504/FAIRsharing.3f9n4y; Last edited: June 16, 2021, 1:17 p.m.; Last accessed: Jan 03 2022 7:06 p.m.
Open Targets has designed and developed a data integration and visualization platform that provides evidence about the association of known and potential drug targets with diseases. The platform is designed to support identification and prioritization of biological targets for follow-up. Each drug target is linked to a disease using integrated genome-wide data from a broad range of data sources. The platform provides either a target-centric workflow to identify diseases that may be associated with a specific target, or a disease-centric workflow to identify targets that may be associated with a specific disease. Users can easily transition between these target- and disease-centric workflows.
metasource: Nucleic Acid Research database catalogueversion: extracted_at: 2022-11-04T11:16:25.468657
The Open Targets Platform is a comprehensive tool that supports systematic identification and prioritisation of potential therapeutic drug targets. By integrating publicly available datasets including data generated by the Open Targets consortium, the Platform builds and scores target-disease associations to assist in drug target identification and prioritisation. It also integrates relevant annotation information about targets, diseases, phenotypes, and drugs, as well as their most relevant relationships. The Platform is a freely available resource that is actively maintained with bi-monthly updates. The data can be accessed through an intuitive web user interface, an API, Google BigQuery, and a comprehensive set of datasets available for download in JSON and Parquet formats. The pipeline and infrastructure codebases that support the Platform are open-source and can be used to create a self-hosted private instance of the Platform with custom data.
metasource: bio.toolsversion: extracted_at: 2022-11-04T11:25:09.130710
Webpage:
https://www.targetvalidation.orgWebpage
More detailed information about this field from each metasource.
https://www.targetvalidation.org
metasource: BiŌkeanós-Medsourcingversion: 0.0.1:2022-11-04T13:34:25.975929
https://platform.opentargets.org/
metasource: Fairsharing.orgversion: FAIRsharing.org: Open Targets; Open Targets; DOI: https://doi.org/10.25504/FAIRsharing.3f9n4y; Last edited: June 16, 2021, 1:17 p.m.; Last accessed: Jan 03 2022 7:06 p.m.
https://www.targetvalidation.org/
metasource: Nucleic Acid Research database catalogueversion: extracted_at: 2022-11-04T11:16:25.468657
https://platform.opentargets.org
metasource: bio.toolsversion: extracted_at: 2022-11-04T11:25:09.130710
Licence:
Name: Open Targets - specific. As an aggregator they do not put any restrictions themselvesLicence name
More detailed information about this field from each metasource.
Open Targets - specific. As an aggregator they do not put any restrictions themselves
metasource: BiŌkeanós-Medsourcingversion: 0.0.1:2022-11-04T13:34:25.975929
Open Target Terms of Use
metasource: Fairsharing.orgversion: FAIRsharing.org: Open Targets; Open Targets; DOI: https://doi.org/10.25504/FAIRsharing.3f9n4y; Last edited: June 16, 2021, 1:17 p.m.; Last accessed: Jan 03 2022 7:06 p.m.
Apache-2.0
metasource: bio.toolsversion: extracted_at: 2022-11-04T11:25:09.130710
Licence URL
More detailed information about this field from each metasource.
https://www.targetvalidation.org/terms-of-use
metasource: BiŌkeanós-Medsourcingversion: 0.0.1:2022-11-04T13:34:25.975929
https://platform-docs.opentargets.org/terms-of-use
metasource: Fairsharing.orgversion: FAIRsharing.org: Open Targets; Open Targets; DOI: https://doi.org/10.25504/FAIRsharing.3f9n4y; Last edited: June 16, 2021, 1:17 p.m.; Last accessed: Jan 03 2022 7:06 p.m.
Publications:
(7)
Publications
More detailed information about this field from each metasource.
Open Targets Platform: new developments and updates two years on
PMID: 30462303
metasource: BiŌkeanós-Medsourcing
version: 0.0.1:2022-11-04T13:34:25.975929
metasource: Fairsharing.org
version: FAIRsharing.org: Open Targets; Open Targets; DOI: https://doi.org/10.25504/FAIRsharing.3f9n4y; Last edited: June 16, 2021, 1:17 p.m.; Last accessed: Jan 03 2022 7:06 p.m.
metasource: bio.tools
version: extracted_at: 2022-11-04T11:25:09.130710
Open Targets: a platform for therapeutic target identification and validation
PMID: 27899665
metasource: BiŌkeanós-Medsourcing
version: 0.0.1:2022-11-04T13:34:25.975929
metasource: Fairsharing.org
version: FAIRsharing.org: Open Targets; Open Targets; DOI: https://doi.org/10.25504/FAIRsharing.3f9n4y; Last edited: June 16, 2021, 1:17 p.m.; Last accessed: Jan 03 2022 7:06 p.m.
metasource: bio.tools
version: extracted_at: 2022-11-04T11:25:09.130710
Open Targets Platform: supporting systematic drug-target identification and prioritisation
PMID: 33196847
metasource: BiŌkeanós-Medsourcing
version: 0.0.1:2022-11-04T13:34:25.975929
metasource: Fairsharing.org
version: FAIRsharing.org: Open Targets; Open Targets; DOI: https://doi.org/10.25504/FAIRsharing.3f9n4y; Last edited: June 16, 2021, 1:17 p.m.; Last accessed: Jan 03 2022 7:06 p.m.
metasource: bio.tools
version: extracted_at: 2022-11-04T11:25:09.130710
https://doi.org/10.1093/nar/gkaa1027
metasource: BiŌkeanós-Medsourcing
version: 0.0.1:2022-11-04T13:34:25.975929
https://doi.org/10.1093/nar/gkw1055
metasource: BiŌkeanós-Medsourcing
version: 0.0.1:2022-11-04T13:34:25.975929
https://doi.org/10.1093/nar/gky1133
metasource: BiŌkeanós-Medsourcing
version: 0.0.1:2022-11-04T13:34:25.975929
http://dx.doi.org/10.1093/nar/1988
metasource: Nucleic Acid Research database catalogue
version: extracted_at: 2022-11-04T11:16:25.468657
Publications
More detailed information about this field from each metasource.
Open Targets Platform: new developments and updates two years on
PMID: 30462303
metasource: BiŌkeanós-Medsourcing
version: 0.0.1:2022-11-04T13:34:25.975929
metasource: Fairsharing.org
version: FAIRsharing.org: Open Targets; Open Targets; DOI: https://doi.org/10.25504/FAIRsharing.3f9n4y; Last edited: June 16, 2021, 1:17 p.m.; Last accessed: Jan 03 2022 7:06 p.m.
metasource: bio.tools
version: extracted_at: 2022-11-04T11:25:09.130710
Open Targets: a platform for therapeutic target identification and validation
PMID: 27899665
metasource: BiŌkeanós-Medsourcing
version: 0.0.1:2022-11-04T13:34:25.975929
metasource: Fairsharing.org
version: FAIRsharing.org: Open Targets; Open Targets; DOI: https://doi.org/10.25504/FAIRsharing.3f9n4y; Last edited: June 16, 2021, 1:17 p.m.; Last accessed: Jan 03 2022 7:06 p.m.
metasource: bio.tools
version: extracted_at: 2022-11-04T11:25:09.130710
Open Targets Platform: supporting systematic drug-target identification and prioritisation
PMID: 33196847
metasource: BiŌkeanós-Medsourcing
version: 0.0.1:2022-11-04T13:34:25.975929
metasource: Fairsharing.org
version: FAIRsharing.org: Open Targets; Open Targets; DOI: https://doi.org/10.25504/FAIRsharing.3f9n4y; Last edited: June 16, 2021, 1:17 p.m.; Last accessed: Jan 03 2022 7:06 p.m.
metasource: bio.tools
version: extracted_at: 2022-11-04T11:25:09.130710
https://doi.org/10.1093/nar/gkaa1027
metasource: BiŌkeanós-Medsourcingversion: 0.0.1:2022-11-04T13:34:25.975929
https://doi.org/10.1093/nar/gkw1055
metasource: BiŌkeanós-Medsourcingversion: 0.0.1:2022-11-04T13:34:25.975929
https://doi.org/10.1093/nar/gky1133
metasource: BiŌkeanós-Medsourcingversion: 0.0.1:2022-11-04T13:34:25.975929
http://dx.doi.org/10.1093/nar/1988
metasource: Nucleic Acid Research database catalogueversion: extracted_at: 2022-11-04T11:16:25.468657
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Open Targets Platform: new developments and updates two years on
PubMed citations: 172.
172 articles citing: Open Targets Platform: new developments and updates two years on
Revisiting the Risk Factors for Endometriosis: A Machine Learning Approach. PMID:35887611
Large-Scale Multi-Omics Studies Provide New Insights into Blood Pressure Regulation. PMID:35886906
Genome-Wide Association Study and Gene-Based Analysis of Participants With Hemophilia A and Inhibitors in the My Life, Our Future Research Repository. PMID:35814780
Most Pathways Can Be Related to the Pathogenesis of Alzheimer's Disease. PMID:35813951
Stratification of rheumatoid arthritis cohort using Ayurveda based deep phenotyping approach identifies novel genes in a GWAS. PMID:35793592
3DFAACTS-SNP: using regulatory T cell-specific epigenomics data to uncover candidate mechanisms of type 1 diabetes (T1D) risk. PMID:35773720
The close interaction between hypoxia-related proteins and metastasis in pancarcinomas. PMID:35773405
Identification of novel proteins for lacunar stroke by integrating genome-wide association data and human brain proteomes. PMID:35733147
Thymoquinone (TQ) Inhibits Inflammation and Migration of THP-1 Macrophages: Mechanistic Insights into the Prevention of Atherosclerosis Using In-Vitro and In-Silico Analysis. PMID:35723378
Empowering the discovery of novel target-disease associations via machine learning approaches in the open targets platform. PMID:35710324
Genome-wide association analysis and replication in 810,625 individuals with varicose veins. PMID:35654884
Genetic architecture of band neutrophil fraction in Iceland. PMID:35650273
Consensus Gene Co-Expression Network Analysis Identifies Novel Genes Associated with Severity of Fibrotic Lung Disease. PMID:35628257
A Simple Standard for Sharing Ontological Mappings (SSSOM). PMID:35616100
Whole-exome sequencing identifies rare genetic variants associated with human plasma metabolites. PMID:35568032
A systematic analysis of gene-gene interaction in multiple sclerosis. PMID:35501860
Integrated analysis of microbe-host interactions in Crohn's disease reveals potential mechanisms of microbial proteins on host gene expression. PMID:35479407
Integrating human brain proteomes with genome-wide association data implicates novel proteins in post-traumatic stress disorder. PMID:35449297
Premarket assessment of molecular alterations in drug targets: a case study of 2020 drug approvals. PMID:35440173
Pulmonary Inflammatory Response in Lethal COVID-19 Reveals Potential Therapeutic Targets and Drugs in Phases III/IV Clinical Trials. PMID:35422702
A systematic review and functional bioinformatics analysis of genes associated with Crohn's disease identify more than 120 related genes. PMID:35418025
Genomic Evidence Supports the Recognition of Endometriosis as an Inflammatory Systemic Disease and Reveals Disease-Specific Therapeutic Potentials of Targeting Neutrophil Degranulation. PMID:35401535
An Amish founder population reveals rare-population genetic determinants of the human lipidome. PMID:35393526
Purinergic Receptors in the Airways: Potential Therapeutic Targets for Asthma? PMID:35386996
Translational Analysis of Moderate to Severe Asthma GWAS Signals Into Candidate Causal Genes and Their Functional, Tissue-Dependent and Disease-Related Associations. PMID:35386986
Mechanisms of Action of a Herbal Formula Huangqi Guizhi Wuwu Tang for the Management of Post-Stroke Related Numbness and Weakness: A Computational Molecular Docking Study. PMID:35369720
Expression of polyamines and its association with GnRH-I in the hypothalamus during aging in rodent model. PMID:35286462
PM2.5 exposure during pregnancy is associated with altered placental expression of lipid metabolic genes in a US birth cohort. PMID:35248564
A Novel Role of Arrhythmia-Related Gene KCNQ1 Revealed by Multi-Omic Analysis: Theragnostic Value and Potential Mechanisms in Lung Adenocarcinoma. PMID:35216393
Interferon-β Activity Is Affected by S100B Protein. PMID:35216109
Systematic illumination of druggable genes in cancer genomes. PMID:35196490
Imatinib and methazolamide ameliorate COVID-19-induced metabolic complications via elevating ACE2 enzymatic activity and inhibiting viral entry. PMID:35150639
The Cancer Surfaceome Atlas integrates genomic, functional and drug response data to identify actionable targets. PMID:35121907
Insights into the genetic architecture of haematological traits from deep phenotyping and whole-genome sequencing for two Mediterranean isolated populations. PMID:35064169
Erythropoietin Interacts with Specific S100 Proteins. PMID:35053268
Using population-specific add-on polymorphisms to improve genotype imputation in underrepresented populations. PMID:35025869
Dissociation of impulsive traits by subthalamic metabotropic glutamate receptor 4. PMID:34982027
An integrated brain-specific network identifies genes associated with neuropathologic and clinical traits of Alzheimer's disease. PMID:34953465
Long-Term Overconsumption of Fat and Sugar Causes a Partially Reversible Pre-inflammatory Bowel Disease State. PMID:34869528
Artificial Intelligence in Functional Food Ingredient Discovery and Characterisation: A Focus on Bioactive Plant and Food Peptides. PMID:34868255
Identification of NSP3 (SH2D3C) as a Prognostic Biomarker of Tumor Progression and Immune Evasion for Lung Cancer and Evaluation of Organosulfur Compounds from Allium sativum L. as Therapeutic Candidates. PMID:34829812
An open approach to systematically prioritize causal variants and genes at all published human GWAS trait-associated loci. PMID:34711957
A trans-omic Mendelian randomization study of parental lifespan uncovers novel aging biology and therapeutic candidates for chronic diseases. PMID:34704651
Multiomics Identification of Potential Targets for Alzheimer Disease and Antrocin as a Therapeutic Candidate. PMID:34683848
Multi-tissue transcriptome-wide association study identifies eight candidate genes and tissue-specific gene expression underlying endometrial cancer susceptibility. PMID:34675350
Comprehensive Analysis of Key mRNAs and lncRNAs in Osteosarcoma Response to Preoperative Chemotherapy with Prognostic Values. PMID:34671904
Leveraging auxiliary data from arbitrary distributions to boost GWAS discovery with Flexible cFDR. PMID:34669738
DNA Repair and Immune Response Pathways Are Deregulated in Melanocyte-Keratinocyte Co-cultures Derived From the Healthy Skin of Familial Melanoma Patients. PMID:34660619
An interferon-inducible signature of airway disease from blood gene expression profiling. PMID:34649980
The Immunoregulatory Role of the Signal Regulatory Protein Family and CD47 Signaling Pathway in Type 1 Diabetes. PMID:34603322
MXD3 as an onco-immunological biomarker encompassing the tumor microenvironment, disease staging, prognoses, and therapeutic responses in multiple cancer types. PMID:34584637
Non-small-cell lung cancer classification via RNA-Seq and histology imaging probability fusion. PMID:34551733
FIVEx: an interactive eQTL browser across public datasets. PMID:34459872
Seeing the forest through the trees: prioritising potentially functional interactions from Hi-C. PMID:34454581
Drug Discovery of Spinal Muscular Atrophy (SMA) from the Computational Perspective: A Comprehensive Review. PMID:34445667
Identification of ROBO2 as a Potential Locus Associated with Inhaled Corticosteroid Response in Childhood Asthma. PMID:34442380
The acute phase protein lactoferrin is a key feature of Alzheimer's disease and predictor of Aβ burden through induction of APP amyloidogenic processing. PMID:34400772
Genome-wide Association Study Identified Chromosome 8 Locus Associated with Medication-Related Osteonecrosis of the Jaw. PMID:34390503
A polygenic-score-based approach for identification of gene-drug interactions stratifying breast cancer risk. PMID:34363748
Expanding the MECP2 network using comparative genomics reveals potential therapeutic targets for Rett syndrome. PMID:34355696
Expression of AOX1 Predicts Prognosis of Clear Cell Renal Cell Carcinoma. PMID:34290740
Genetic association studies of alterations in protein function expose recessive effects on cancer predisposition. PMID:34290314
Gene Regulatory Network of Human GM-CSF-Secreting T Helper Cells. PMID:34285924
The PROTACtable genome. PMID:34285415
Untangling COVID-19 and autoimmunity: Identification of plausible targets suggests multi organ involvement. PMID:34242919
Down-regulation of BCL2L13 renders poor prognosis in clear cell and papillary renal cell carcinoma. PMID:34193180
The effect of protein mutations on drug binding suggests ensuing personalised drug selection. PMID:34188094
Expression and gene regulation network of TYMS and BCL2L1 in colorectal cancer based on data mining. PMID:34141464
Genetic architecture of 11 organ traits derived from abdominal MRI using deep learning. PMID:34128465
Prioritization of candidate causal genes for asthma in susceptibility loci derived from UK Biobank. PMID:34103634
Systems Pharmacology and In Silico Docking Analysis Uncover Association of CA2, PPARG, RXRA, and VDR with the Mechanisms Underlying the Shi Zhen Tea Formula Effect on Eczema. PMID:34055023
Human plasma proteomic profiles indicative of cardiorespiratory fitness. PMID:34045743
Unraveling the Catha edulis Extract Effects on the Cellular and Molecular Signaling in SKOV3 Cells. PMID:34040530
Utilizing graph machine learning within drug discovery and development. PMID:34013350
SynLeGG: analysis and visualization of multiomics data for discovery of cancer 'Achilles Heels' and gene function relationships. PMID:33997893
Genetic variation affects morphological retinal phenotypes extracted from UK Biobank optical coherence tomography images. PMID:33979322
Predictive value of RAD51 on the survival and drug responsiveness of ovarian cancer. PMID:33952262
Genome-wide association study identifies RNF123 locus as associated with chronic widespread musculoskeletal pain. PMID:33926923
In Silico Exploration of the Potential Role of Acetaminophen and Pesticides in the Etiology of Autism Spectrum Disorder. PMID:33925648
A New Insight for the Identification of Oncogenic Variants in Breast and Prostate Cancers in Diverse Human Populations, With a Focus on Latinos. PMID:33912047
An expanded set of genome-wide association studies of brain imaging phenotypes in UK Biobank. PMID:33875891
The evolutionary biology of endometriosis. PMID:33854783
Brain proteome-wide association study implicates novel proteins in depression pathogenesis. PMID:33846625
Artificial intelligence to deep learning: machine intelligence approach for drug discovery. PMID:33844136
MendelVar: gene prioritization at GWAS loci using phenotypic enrichment of Mendelian disease genes. PMID:33836063
Genome-wide enhancer maps link risk variants to disease genes. PMID:33828297
Emerging Role of ODC1 in Neurodevelopmental Disorders and Brain Development. PMID:33806076
Absence of RNA-binding protein FXR2P prevents prolonged phase of kainate-induced seizures. PMID:33779029
KnetMiner: a comprehensive approach for supporting evidence-based gene discovery and complex trait analysis across species. PMID:33750020
A small molecule compound berberine as an orally active therapeutic candidate against COVID-19 and SARS: A computational and mechanistic study. PMID:33749932
Advancing drug discovery using the power of the human genome. PMID:33748968
Towards realizing the vision of precision medicine: AI based prediction of clinical drug response. PMID:33734308
Receptor Tyrosine Kinase Signaling and Targeting in Glioblastoma Multiforme. PMID:33673213
Colocalization analysis of polycystic ovary syndrome to identify potential disease-mediating genes and proteins. PMID:33664499
System Genetics Including Causal Inference Identify Immune Targets for Coronary Artery Disease and the Lifespan. PMID:33625251
Using Bibliometric Analysis and Machine Learning to Identify Compounds Binding to Sialidase-1. PMID:33553934
Multiomics-Identified Intervention to Restore Ethanol-Induced Dysregulated Proteostasis and Secondary Sarcopenia in Alcoholic Liver Disease. PMID:33543862
Artificial intelligence in drug discovery: what is realistic, what are illusions? Part 2: a discussion of chemical and biological data. PMID:33508423
Common genetic variants and modifiable risk factors underpin hypertrophic cardiomyopathy susceptibility and expressivity. PMID:33495597
Machine learning applications in drug development. PMID:33489002
De-coding genetic risk variants in type 1 diabetes. PMID:33483996
Genetics of 35 blood and urine biomarkers in the UK Biobank. PMID:33462484
Artificial Intelligence in Drug Discovery: A Comprehensive Review of Data-driven and Machine Learning Approaches. PMID:33437151
Transcriptomic landscaping of core genes and pathways of mild and severe psoriasis vulgaris. PMID:33416099
Germline variants are associated with increased primary melanoma tumor thickness at diagnosis. PMID:33410475
A Neutrophil-Driven Inflammatory Signature Characterizes the Blood Transcriptome Fingerprint of Psoriasis. PMID:33329570
Oncology and Pharmacogenomics Insights in Polycystic Ovary Syndrome: An Integrative Analysis. PMID:33329391
Leveraging phenotypic variability to identify genetic interactions in human phenotypes. PMID:33326753
Interferon Beta Activity Is Modulated via Binding of Specific S100 Proteins. PMID:33322098
Expression of PAWR predicts prognosis of ovarian cancer. PMID:33317551
Understanding the Molecular Drivers of Disease Heterogeneity in Crohn's Disease Using Multi-omic Data Integration and Network Analysis. PMID:33313682
Genome-wide association study of asthma exacerbations despite inhaled corticosteroid use. PMID:33303529
A ligand-based computational drug repurposing pipeline using KNIME and Programmatic Data Access: case studies for rare diseases and COVID-19. PMID:33250934
The European Bioinformatics Institute: empowering cooperation in response to a global health crisis. PMID:33245775
UniProt: the universal protein knowledgebase in 2021. PMID:33237286
Anti-inflammatory activity of Radix Angelicae biseratae in the treatment of osteoarthritis determined by systematic pharmacology and in vitro experiments. PMID:33235614
RNA-binding proteins in human genetic disease. PMID:33235359
Moving targets in drug discovery. PMID:33214619
Open Targets Platform: supporting systematic drug-target identification and prioritisation. PMID:33196847
In silico predictions on the possible mechanism of action of selected bioactive compounds against breast cancer. PMID:33194532
Europe PMC in 2020. PMID:33180112
Pan-transcriptome-based candidate therapeutic discovery for idiopathic pulmonary fibrosis. PMID:33167785
EpiGraphDB: a database and data mining platform for health data science. PMID:33165574
The association of clinical phenotypes to known AD/FTD genetic risk loci and their inter-relationship. PMID:33152005
Genome-Wide Association Study of Metamizole-Induced Agranulocytosis in European Populations. PMID:33138277
Perturbation-Theory Machine Learning (PTML) Multilabel Model of the ChEMBL Dataset of Preclinical Assays for Antisarcoma Compounds. PMID:33134682
Systemic analyses of expression patterns and clinical features for GIMAPs family members in lung adenocarcinoma. PMID:33115964
Preclinical validation of therapeutic targets predicted by tensor factorization on heterogeneous graphs. PMID:33106501
Genome-wide association studies of antidepressant class response and treatment-resistant depression. PMID:33106475
Combined genetic analysis of juvenile idiopathic arthritis clinical subtypes identifies novel risk loci, target genes and key regulatory mechanisms. PMID:33106285
OATargets: a knowledge base of genes associated with osteoarthritis joint damage in animals. PMID:33077471
Open Targets Genetics: systematic identification of trait-associated genes using large-scale genetics and functional genomics. PMID:33045747
CMNPD: a comprehensive marine natural products database towards facilitating drug discovery from the ocean. PMID:32986829
A Systematic Pharmacology and In Vitro Study to Identify the Role of the Active Compounds of Achyranthes bidentata in the Treatment of Osteoarthritis. PMID:32925869
TargetDB: A target information aggregation tool and tractability predictor. PMID:32877430
Associated Targets of the Antioxidant Cardioprotection of Ganoderma lucidum in Diabetic Cardiomyopathy by Using Open Targets Platform: A Systematic Review. PMID:32775437
A modular framework for the development of targeted Covid-19 blood transcript profiling panels. PMID:32736569
A Coordinated Approach by Public Domain Bioinformatics Resources to Aid the Fight Against Alzheimer's Disease Through Expert Curation of Key Protein Targets. PMID:32716361
PWAS: proteome-wide association study-linking genes and phenotypes by functional variation in proteins. PMID:32665031
Decoding the Role of Sphingosine-1-Phosphate in Asthma and Other Respiratory System Diseases Using Next Generation Knowledge Discovery Platforms Coupled With Luminex Multiple Analyte Profiling Technology. PMID:32637407
Inhibitory receptor agonists: the future of autoimmune disease therapeutics? PMID:32619929
Heparin-Binding Protein: A Novel Biomarker Linking Four Different Cardiovascular Diseases. PMID:32612856
Genome-wide investigation of gene-cancer associations for the prediction of novel therapeutic targets in oncology. PMID:32612205
Molecular Characterization of Astrocytoma Progression Towards Secondary Glioblastomas Utilizing Patient-Matched Tumor Pairs. PMID:32604718
Comprehensive Analysis of Key Genes and Regulatory Elements in Osteosarcoma Affected by Bone Matrix Mineral With Prognostic Values. PMID:32582282
Multi-trait analysis of rare-variant association summary statistics using MTAR. PMID:32503972
The Long-Term Effects of Early Life Stress on the Modulation of miR-19 Levels. PMID:32499725
Structure-based drug repositioning explains ibrutinib as VEGFR2 inhibitor. PMID:32459810
Prediction of breast cancer proteins involved in immunotherapy, metastasis, and RNA-binding using molecular descriptors and artificial neural networks. PMID:32444848
Extending the small-molecule similarity principle to all levels of biology with the Chemical Checker. PMID:32440005
Genome-Wide Association Meta-Analysis of Single-Nucleotide Polymorphisms and Symptomatic Venous Thromboembolism during Therapy for Acute Lymphoblastic Leukemia and Lymphoma in Caucasian Children. PMID:32438682
Drug repositioning for psychiatric and neurological disorders through a network medicine approach. PMID:32398742
Mutational dynamics and immune evasion in diffuse large B-cell lymphoma explored in a relapse-enriched patient series. PMID:32374878
Single-cell expression and Mendelian randomization analyses identify blood genes associated with lifespan and chronic diseases. PMID:32358504
OncoOmics approaches to reveal essential genes in breast cancer: a panoramic view from pathogenesis to precision medicine. PMID:32210335
Temporal changes in the gene expression heterogeneity during brain development and aging. PMID:32139741
Exploration of databases and methods supporting drug repurposing: a comprehensive survey. PMID:32055842
Microtubule-Associated Proteins with Regulatory Functions by Day and Pathological Potency at Night. PMID:32033023
Novel approaches leading towards peptide GPCR de-orphanisation. PMID:31863461
BIOPEP-UWM Database of Bioactive Peptides: Current Opportunities. PMID:31783634
Differential Functions of Splicing Factors in Mammary Transformation and Breast Cancer Metastasis. PMID:31775037
Comorbidity of asthma and hypertension may be mediated by shared genetic dysregulation and drug side effects. PMID:31705029
Therapeutic target database 2020: enriched resource for facilitating research and early development of targeted therapeutics. PMID:31691823
GWAS for systemic sclerosis identifies multiple risk loci and highlights fibrotic and vasculopathy pathways. PMID:31672989
Expression Atlas update: from tissues to single cells. PMID:31665515
Pharmacogenomics, biomarker network, and allele frequencies in colorectal cancer. PMID:31616044
Pharmacogenomics and Placebo Response in a Randomized Clinical Trial in Asthma. PMID:31557306
Gene mapping and molecular analysis of hereditarynon-polyposis colorectal cancer (Lynch Syndrome)using systems biological approaches. PMID:31285644
Combined analysis of keratinocyte cancers identifies novel genome-wide loci. PMID:31174203
Geneshot: search engine for ranking genes from arbitrary text queries. PMID:31114885
Chromatin interactions reveal novel gene targets for drug repositioning in rheumatic diseases. PMID:31092410
The European Bioinformatics Institute in 2018: tools, infrastructure and training. PMID:30445657 -
Open Targets: a platform for therapeutic target identification and validation
PubMed citations: 154.
154 articles citing: Open Targets: a platform for therapeutic target identification and validation
Exploiting gene dependency to inform drug development for multiple myeloma. PMID:35882937
Most Pathways Can Be Related to the Pathogenesis of Alzheimer's Disease. PMID:35813951
Thymoquinone (TQ) Inhibits Inflammation and Migration of THP-1 Macrophages: Mechanistic Insights into the Prevention of Atherosclerosis Using In-Vitro and In-Silico Analysis. PMID:35723378
Empowering the discovery of novel target-disease associations via machine learning approaches in the open targets platform. PMID:35710324
Germinal Center-Related G Protein-Coupled Receptors in Antibody-Mediated Autoimmune Skin Diseases: from Basic Research to Clinical Trials. PMID:35674978
Mining database and verification of PIK3CB as a marker predicting prognosis and immune infiltration in renal clear cell carcinoma. PMID:35665729
Endophenotype-based in silico network medicine discovery combined with insurance record data mining identifies sildenafil as a candidate drug for Alzheimer's disease. PMID:35572351
Understudied proteins: opportunities and challenges for functional proteomics. PMID:35534633
Disentangling Signatures of Selection Before and After European Colonization in Latin Americans. PMID:35460423
Premarket assessment of molecular alterations in drug targets: a case study of 2020 drug approvals. PMID:35440173
A Pan-Cancer Bioinformatic Analysis of RAD51 Regarding the Values for Diagnosis, Prognosis, and Therapeutic Prediction. PMID:35359409
Prediction of Drug Targets for Specific Diseases Leveraging Gene Perturbation Data: A Machine Learning Approach. PMID:35213968
The correlation and role analysis of SLC30A1 and SLC30A10 in cervical carcinoma. PMID:35154468
Artificial intelligence framework identifies candidate targets for drug repurposing in Alzheimer's disease. PMID:35012639
Identification of Therapeutic Targets and Prognostic Biomarkers Among Chemokine (C-C Motif) Ligands in the Liver Hepatocellular Carcinoma Microenvironment. PMID:34938730
Artificial intelligence in clinical research of cancers. PMID:34929741
Genome-Wide Association and Mendelian Randomization Analysis Reveal the Causal Relationship Between White Blood Cell Subtypes and Asthma in Africans. PMID:34925446
Drug-Repositioning Approaches Based on Medical and Life Science Databases. PMID:34790124
An open approach to systematically prioritize causal variants and genes at all published human GWAS trait-associated loci. PMID:34711957
Evidence for GRN connecting multiple neurodegenerative diseases. PMID:34693284
YTHDF2 is a Potential Biomarker and Associated with Immune Infiltration in Kidney Renal Clear Cell Carcinoma. PMID:34512342
FORUM: Building a Knowledge Graph from public databases and scientific literature to extract associations between chemicals and diseases. PMID:34478489
A systematic comparison of data- and knowledge-driven approaches to disease subtype discovery. PMID:34396389
Machine Learning in Drug Discovery: A Review. PMID:34393317
Comprior: facilitating the implementation and automated benchmarking of prior knowledge-based feature selection approaches on gene expression data sets. PMID:34384353
Identification and Validation of PIK3CA as a Marker Associated with Prognosis and Immune Infiltration in Renal Clear Cell Carcinoma. PMID:34367282
The PROTACtable genome. PMID:34285415
Predicting biological pathways of chemical compounds with a profile-inspired approach. PMID:34118870
Genome-wide association study on blood pressure traits in the Iranian population suggests ZBED9 as a new locus for hypertension. PMID:34083597
Unraveling the Catha edulis Extract Effects on the Cellular and Molecular Signaling in SKOV3 Cells. PMID:34040530
Complementing the pulp proteome via sampling with a picosecond infrared laser (PIRL). PMID:33977388
Antiulcer Potential of Olea europea L. cv. Arbequina Leaf Extract Supported by Metabolic Profiling and Molecular Docking. PMID:33922167
A catalog of GWAS fine-mapping efforts in autoimmune disease. PMID:33798443
Herb-target virtual screening and network pharmacology for prediction of molecular mechanism of Danggui Beimu Kushen Wan for prostate cancer. PMID:33758314
Search and visualization of gene-drug-disease interactions for pharmacogenomics and precision medicine research using GeneDive. PMID:33737208
Identification of circulating biomarkers for differentiating patients with papillary thyroid cancers from benign thyroid tumors. PMID:33646556
Clinical-grade whole-genome sequencing and 3' transcriptome analysis of colorectal cancer patients. PMID:33632293
Genome-wide meta-analysis identifies 127 open-angle glaucoma loci with consistent effect across ancestries. PMID:33627673
Integrated network analysis reveals new genes suggesting COVID-19 chronic effects and treatment. PMID:33569598
Identifying drug targets for neurological and psychiatric disease via genetics and the brain transcriptome. PMID:33417599
CXCL10 is a potential biomarker and associated with immune infiltration in human papillary thyroid cancer. PMID:33345267
Whole-genome sequencing analysis of the cardiometabolic proteome. PMID:33303764
A powerful method for pleiotropic analysis under composite null hypothesis identifies novel shared loci between Type 2 Diabetes and Prostate Cancer. PMID:33290408
Network and pathway expansion of genetic disease associations identifies successful drug targets. PMID:33262371
Towards a unified open access dataset of molecular interactions. PMID:33262342
Integrated Proteogenomic Characterization across Major Histological Types of Pediatric Brain Cancer. PMID:33242424
Anti-inflammatory activity of Radix Angelicae biseratae in the treatment of osteoarthritis determined by systematic pharmacology and in vitro experiments. PMID:33235614
Network-based approach highlighting interplay among anti-hypertensives: target coding-genes: diseases. PMID:33214616
Improving target assessment in biomedical research: the GOT-IT recommendations. PMID:33199880
Open Targets Platform: supporting systematic drug-target identification and prioritisation. PMID:33196847
PRAP1 is a novel lipid-binding protein that promotes lipid absorption by facilitating MTTP-mediated lipid transport. PMID:33168624
EpiGraphDB: a database and data mining platform for health data science. PMID:33165574
Clustering of Alzheimer's and Parkinson's disease based on genetic burden of shared molecular mechanisms. PMID:33154531
A holistic view of mouse enhancer architectures reveals analogous pleiotropic effects and correlation with human disease. PMID:33138777
Potential novel proteomic biomarkers for diagnosis of vertebral osteomyelitis identified using an immunomics protein array technique: Two cases reports. PMID:33120821
Project Score database: a resource for investigating cancer cell dependencies and prioritizing therapeutic targets. PMID:33068406
Open Targets Genetics: systematic identification of trait-associated genes using large-scale genetics and functional genomics. PMID:33045747
A deoxyribonuclease 1-like 3 genetic variant associates with asthma exacerbations. PMID:33035569
Genome-wide Study Identifies Association between HLA-B∗55:01 and Self-Reported Penicillin Allergy. PMID:32888428
Multiomics dissection of molecular regulatory mechanisms underlying autoimmune-associated noncoding SNPs. PMID:32879140
Genome-wide association study reveals a novel locus for asthma with severe exacerbations in diverse populations. PMID:32841424
Advances in Genomics for Drug Development. PMID:32824125
Antifungal drug miconazole ameliorated memory deficits in a mouse model of LPS-induced memory loss through targeting iNOS. PMID:32796824
Associated Targets of the Antioxidant Cardioprotection of Ganoderma lucidum in Diabetic Cardiomyopathy by Using Open Targets Platform: A Systematic Review. PMID:32775437
Rapid, deep and precise profiling of the plasma proteome with multi-nanoparticle protein corona. PMID:32699280
Machine learning and AI-based approaches for bioactive ligand discovery and GPCR-ligand recognition. PMID:32645448
Decoding the Role of Sphingosine-1-Phosphate in Asthma and Other Respiratory System Diseases Using Next Generation Knowledge Discovery Platforms Coupled With Luminex Multiple Analyte Profiling Technology. PMID:32637407
Heparin-Binding Protein: A Novel Biomarker Linking Four Different Cardiovascular Diseases. PMID:32612856
Semantic text mining in early drug discovery for type 2 diabetes. PMID:32542027
Multi-trait analysis of rare-variant association summary statistics using MTAR. PMID:32503972
PS4DR: a multimodal workflow for identification and prioritization of drugs based on pathway signatures. PMID:32503412
Pharmacogenetics: An Important Part of Drug Development with A Focus on Its Application. PMID:32467882
ThETA: transcriptome-driven efficacy estimates for gene-based TArget discovery. PMID:32437556
Drug repositioning or target repositioning: A structural perspective of drug-target-indication relationship for available repurposed drugs. PMID:32419905
A Novel Method to Identify Autoantibodies against Putative Target Proteins in Serum from beta-Thalassemia Major: A Pilot Study. PMID:32357536
PRIORI-T: A tool for rare disease gene prioritization using MEDLINE. PMID:32315351
ncRPheno: a comprehensive database platform for identification and validation of disease related noncoding RNAs. PMID:32122231
A polygenic predictor of treatment-resistant depression using whole exome sequencing and genome-wide genotyping. PMID:32066715
Using Informatics Tools to Identify Opportunities for Precision Medicine in Diffuse Large B-cell Lymphoma. PMID:32063526
Pharmacogenetic investigation of efficacy response to mepolizumab in eosinophilic granulomatosis with polyangiitis. PMID:32009195
A possible role for autoimmunity through molecular mimicry in alphavirus mediated arthritis. PMID:31969581
How to Illuminate the Druggable Genome Using Pharos. PMID:31898878
Cardioinformatics: the nexus of bioinformatics and precision cardiology. PMID:31802103
An omics perspective on drug target discovery platforms. PMID:31774113
A network-based approach to identify deregulated pathways and drug effects in metabolic syndrome. PMID:31740673
PCOSBase: a manually curated database of polycystic ovarian syndrome. PMID:31725861
Therapeutic target database 2020: enriched resource for facilitating research and early development of targeted therapeutics. PMID:31691823
'One DB to rule them all'-the RING: a Regulatory INteraction Graph combining TFs, genes/proteins, SNPs, diseases and drugs. PMID:31682269
Discovery of Human Signaling Systems: Pairing Peptides to G Protein-Coupled Receptors. PMID:31675498
A Survey of Gene Prioritization Tools for Mendelian and Complex Human Diseases. PMID:31494632
Benchmarking network propagation methods for disease gene identification. PMID:31479437
Genome-wide profiling of DNA methylome and transcriptome in peripheral blood monocytes for major depression: A Monozygotic Discordant Twin Study. PMID:31477685
Quantifying Risk Pathway Crosstalk Mediated by miRNA to Screen Precision drugs for Breast Cancer Patients. PMID:31466383
The landscape of novel and complementary targets for immunotherapy: an analysis of gene expression in the tumor microenvironment. PMID:31360302
Current opportunities to catalyze research in nutrition and cancer prevention - an interdisciplinary perspective. PMID:31357989
Experimental evidence and network pharmacology identify the molecular targets of Tong Sheng tablets in cerebral ischemia reperfusion injury. PMID:31312345
Gene mapping and molecular analysis of hereditarynon-polyposis colorectal cancer (Lynch Syndrome)using systems biological approaches. PMID:31285644
Prioritizing target-disease associations with novel safety and efficacy scoring methods. PMID:31285471
Exploring the dark genome: implications for precision medicine. PMID:31270560
A genetics-led approach defines the drug target landscape of 30 immune-related traits. PMID:31253980
In Silico Toxicology Data Resources to Support Read-Across and (Q)SAR. PMID:31244651
Shared Molecular Signatures Across Neurodegenerative Diseases and Herpes Virus Infections Highlights Potential Mechanisms for Maladaptive Innate Immune Responses. PMID:31217489
A Perspective on Extreme Open Science: Companies Sharing Compounds without Restriction. PMID:31034310
Applications of machine learning in drug discovery and development. PMID:30976107
Elucidating the druggability of the human proteome with eFindSite. PMID:30888556
Curating gene sets: challenges and opportunities for integrative analysis. PMID:30888410
GREP: genome for REPositioning drugs. PMID:30859178
MorCVD: A Unified Database for Host-Pathogen Protein-Protein Interactions of Cardiovascular Diseases Related to Microbes. PMID:30858555
Transcriptome Profiling and Molecular Therapeutic Advances in Cystic Fibrosis: Recent Insights. PMID:30813620
Free Accessible Databases as a Source of Information about Food Components and Other Compounds with Anticancer Activity⁻Brief Review. PMID:30813234
Predicting clinically promising therapeutic hypotheses using tensor factorization. PMID:30736745
Identification of new therapeutic targets for osteoarthritis through genome-wide analyses of UK Biobank data. PMID:30664745
Genome-wide meta-analysis reveals shared new loci in systemic seropositive rheumatic diseases. PMID:30573655
Open Targets Platform: new developments and updates two years on. PMID:30462303
The NHGRI-EBI GWAS Catalog of published genome-wide association studies, targeted arrays and summary statistics 2019. PMID:30445434
Over expression of DNA damage and cell cycle dependent proteins are associated with poor survival in patients with adrenocortical carcinoma. PMID:30413320
Dual Inhibitors of PARPs and ROCKs. PMID:30411017
ChEMBL: towards direct deposition of bioassay data. PMID:30398643
The PRIDE database and related tools and resources in 2019: improving support for quantification data. PMID:30395289
COSMIC: the Catalogue Of Somatic Mutations In Cancer. PMID:30371878
PopHumanScan: the online catalog of human genome adaptation. PMID:30335169
Editorial: Drug Repositioning: Current Advances and Future Perspectives. PMID:30294274
The COSMIC Cancer Gene Census: describing genetic dysfunction across all human cancers. PMID:30293088
Uncovering new disease indications for G-protein coupled receptors and their endogenous ligands. PMID:30285606
Human genes: Time to follow the roads less traveled? PMID:30256779
Approaches to target tractability assessment - a practical perspective. PMID:30108951
Computational resources associating diseases with genotypes, phenotypes and exposures. PMID:30102366
Searching the overlap between network modules with specific betweeness (S2B) and its application to cross-disease analysis. PMID:30068933
Human coelomic fluid investigation: A MS-based analytical approach to prenatal screening. PMID:30030477
Connecting genetics and gene expression data for target prioritisation and drug repositioning. PMID:29881461
Changing Trends in Computational Drug Repositioning. PMID:29874824
Genetic-Driven Druggable Target Identification and Validation. PMID:29803319
Multiclass classification for skin cancer profiling based on the integration of heterogeneous gene expression series. PMID:29750795
The Novel Roles of Connexin Channels and Tunneling Nanotubes in Cancer Pathogenesis. PMID:29695070
Sequential regulatory activity prediction across chromosomes with convolutional neural networks. PMID:29588361
Worldwide Protein Data Bank validation information: usage and trends. PMID:29533231
Biological annotation of genetic loci associated with intelligence in a meta-analysis of 87,740 individuals. PMID:29520040
Polysaccharide from Angelica sinensis protects H9c2 cells against oxidative injury and endoplasmic reticulum stress by activating the ATF6 pathway. PMID:29517941
Unexplored therapeutic opportunities in the human genome. PMID:29472638
Enhancing the Promise of Drug Repositioning through Genetics. PMID:29270124
Pharmacogenomics of GPCR Drug Targets. PMID:29249361
Expression Atlas: gene and protein expression across multiple studies and organisms. PMID:29165655
Drug target ontology to classify and integrate drug discovery data. PMID:29122012
Computer simulation models as a tool to investigate the role of microRNAs in osteoarthritis. PMID:29095952
Trends in GPCR drug discovery: new agents, targets and indications. PMID:29075003
A Review of Recent Advances in Translational Bioinformatics: Bridges from Biology to Medicine. PMID:29063562
Evidence-Based Precision Oncology with the Cancer Targetome. PMID:28964549
Drug enrichment and discovery from schizophrenia genome-wide association results: an analysis and visualisation approach. PMID:28963561
SciLite: a platform for displaying text-mined annotations as a means to link research articles with biological data. PMID:28948232
In silico prediction of novel therapeutic targets using gene-disease association data. PMID:28851378
Using ChEMBL web services for building applications and data processing workflows relevant to drug discovery. PMID:28602100
Literature evidence in open targets - a target validation platform. PMID:28587637
The 24th annual Nucleic Acids Research database issue: a look back and upcoming changes. PMID:28053160
The ChEMBL database in 2017. PMID:27899562 -
Open Targets Platform: supporting systematic drug-target identification and prioritisation
PubMed citations: 57.
57 articles citing: Open Targets Platform: supporting systematic drug-target identification and prioritisation
Genome-wide association study identifies Sjögren's risk loci with functional implications in immune and glandular cells. PMID:35896530
Genome-wide analyses of 200,453 individuals yield new insights into the causes and consequences of clonal hematopoiesis. PMID:35835912
Systematic discovery and perturbation of regulatory genes in human T cells reveals the architecture of immune networks. PMID:35817986
Vascular Dysfunction Is Central to Alzheimer's Disease Pathogenesis in APOE e4 Carriers. PMID:35806110
Molecular Pathogenesis and New Therapeutic Dimensions for Spinal Muscular Atrophy. PMID:35741415
Integrative transcriptome-wide analysis of atopic dermatitis for drug repositioning. PMID:35729261
Thymoquinone (TQ) Inhibits Inflammation and Migration of THP-1 Macrophages: Mechanistic Insights into the Prevention of Atherosclerosis Using In-Vitro and In-Silico Analysis. PMID:35723378
Text Mining Protocol to Retrieve Significant Drug-Gene Interactions from PubMed Abstracts. PMID:35713857
StarGazer: A Hybrid Intelligence Platform for Drug Target Prioritization and Digital Drug Repositioning Using Streamlit. PMID:35711912
Empowering the discovery of novel target-disease associations via machine learning approaches in the open targets platform. PMID:35710324
Network approaches for modeling the effect of drugs and diseases. PMID:35704883
Investigation of the mechanism of Shen Qi Wan prescription in the treatment of T2DM via network pharmacology and molecular docking. PMID:35673584
Different Effects on Protein Expression of CDR132L, an Antisense Inhibitor of miR-132, and Standard Therapies for Myocardial Infarction. PMID:35647075
Meta-Analysis of Two Human RNA-seq Datasets to Determine Periodontitis Diagnostic Biomarkers and Drug Target Candidates. PMID:35628390
PiER: web-based facilities tailored for genetic target prioritisation harnessing human disease genetics, functional genomics and protein interactions. PMID:35610036
Immune disease variants modulate gene expression in regulatory CD4+ T cells. PMID:35591976
Comprehensive and integrative analyses identify TYW5 as a schizophrenia risk gene. PMID:35527273
ExPheWas: a platform for cis-Mendelian randomization and gene-based association scans. PMID:35474380
Disentangling Signatures of Selection Before and After European Colonization in Latin Americans. PMID:35460423
Search and sequence analysis tools services from EMBL-EBI in 2022. PMID:35412617
Genomic Evidence Supports the Recognition of Endometriosis as an Inflammatory Systemic Disease and Reveals Disease-Specific Therapeutic Potentials of Targeting Neutrophil Degranulation. PMID:35401535
Efficacy and Pharmacological Mechanism of Poria cocos-Based Formulas Combined With Chemotherapy for Ovarian Cancer: A Integrated Systems Pharmacology Study. PMID:35401186
Knowledge Graphs for Indication Expansion: An Explainable Target-Disease Prediction Method. PMID:35360842
Diseases 2.0: a weekly updated database of disease-gene associations from text mining and data integration. PMID:35348648
GOing Forward With the Cardiac Conduction System Using Gene Ontology. PMID:35309148
Comprehensive Analysis of the Expression and Clinical Significance of THO Complex Members in Hepatocellular Carcinoma. PMID:35300138
Causal reasoning over knowledge graphs leveraging drug-perturbed and disease-specific transcriptomic signatures for drug discovery. PMID:35213534
Unlocking the Memory Component of Alzheimer's Disease: Biological Processes and Pathways across Brain Regions. PMID:35204764
Identification of a Novel Theranostic Signature of Metabolic and Immune-Inflammatory Dysregulation in Myocardial Infarction, and the Potential Therapeutic Properties of Ovatodiolide, a Diterpenoid Derivative. PMID:35163208
Advancing drug safety science by integrating molecular knowledge with post-marketing adverse event reports. PMID:35143713
Knowledge graph analytics platform with LINCS and IDG for Parkinson's disease target illumination. PMID:35021991
Computationally prioritized drugs inhibit SARS-CoV-2 infection and syncytia formation. PMID:34962256
Combining Human Genetics of Multiple Sclerosis with Oxidative Stress Phenotype for Drug Repositioning. PMID:34959343
Identification of Potential Genetic Biomarkers and Target Genes of Peri-Implantitis Using Bioinformatics Tools. PMID:34931168
Shared brain transcriptomic signature in TDP-43 type A FTLD patients with or without GRN mutations. PMID:34918030
Mapping the serum proteome to neurological diseases using whole genome sequencing. PMID:34857772
Priority index: database of genetic targets in immune-mediated disease. PMID:34751399
Applications of Artificial Intelligence in Drug Design: Opportunities and Challenges. PMID:34731463
Complex Portal 2022: new curation frontiers. PMID:34718729
An open approach to systematically prioritize causal variants and genes at all published human GWAS trait-associated loci. PMID:34711957
Identification and drug-induced reversion of molecular signatures of Alzheimer's disease onset and progression in AppNL-G-F, AppNL-F, and 3xTg-AD mouse models. PMID:34702310
Computational Approach Reveals Pronociceptive Potential of Cannabidiol in Osteoarthritis: Role of Transient Receptor Potential Channels. PMID:34681188
GWAS Meta-Analysis Reveals Shared Genes and Biological Pathways between Major Depressive Disorder and Insomnia. PMID:34680902
In silico Approach for Validating and Unveiling New Applications for Prognostic Biomarkers of Endometrial Cancer. PMID:34680205
Text Mining for Building Biomedical Networks Using Cancer as a Case Study. PMID:34680062
Epitranscriptomic Approach: To Improve the Efficacy of ICB Therapy by Co-Targeting Intracellular Checkpoint CISH. PMID:34571899
Trends in kinase drug discovery: targets, indications and inhibitor design. PMID:34354255
MOUSSE: Multi-Omics Using Subject-Specific SignaturEs. PMID:34298641
Transcriptional-regulatory convergence across functional MDD risk variants identified by massively parallel reporter assays. PMID:34294677
The PROTACtable genome. PMID:34285415
A Systems Approach to Brain Tumor Treatment. PMID:34202449
Host-Parasite Interaction of Atlantic salmon (Salmo salar) and the Ectoparasite Neoparamoeba perurans in Amoebic Gill Disease. PMID:34135900
The COVID-19 Data Portal: accelerating SARS-CoV-2 and COVID-19 research through rapid open access data sharing. PMID:34048576
Unraveling the Catha edulis Extract Effects on the Cellular and Molecular Signaling in SKOV3 Cells. PMID:34040530
The transcriptional landscape of a hepatoma cell line grown on scaffolds of extracellular matrix proteins. PMID:33823809
The 2021 Nucleic Acids Research database issue and the online molecular biology database collection. PMID:33396976
Mexican Ganoderma Lucidum Extracts Decrease Lipogenesis Modulating Transcriptional Metabolic Networks and Gut Microbiota in C57BL/6 Mice Fed with a High-Cholesterol Diet. PMID:33374283 - https://doi.org/10.1093/nar/gkaa1027
- https://doi.org/10.1093/nar/gkw1055
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abstract
metasource: Fairsharing.org
version: FAIRsharing.org: Open Targets; Open Targets; DOI: https://doi.org/10.25504/FAIRsharing.3f9n4y; Last edited: June 16, 2021, 1:17 p.m.; Last accessed: Jan 03 2022 7:06 p.m.
approved drug
metasource: Fairsharing.org
version: FAIRsharing.org: Open Targets; Open Targets; DOI: https://doi.org/10.25504/FAIRsharing.3f9n4y; Last edited: June 16, 2021, 1:17 p.m.; Last accessed: Jan 03 2022 7:06 p.m.
disease
metasource: Fairsharing.org
version: FAIRsharing.org: Open Targets; Open Targets; DOI: https://doi.org/10.25504/FAIRsharing.3f9n4y; Last edited: June 16, 2021, 1:17 p.m.; Last accessed: Jan 03 2022 7:06 p.m.
disease phenotype
metasource: Fairsharing.org
version: FAIRsharing.org: Open Targets; Open Targets; DOI: https://doi.org/10.25504/FAIRsharing.3f9n4y; Last edited: June 16, 2021, 1:17 p.m.; Last accessed: Jan 03 2022 7:06 p.m.
disease process modeling
metasource: Fairsharing.org
version: FAIRsharing.org: Open Targets; Open Targets; DOI: https://doi.org/10.25504/FAIRsharing.3f9n4y; Last edited: June 16, 2021, 1:17 p.m.; Last accessed: Jan 03 2022 7:06 p.m.
gene report
metasource: Fairsharing.org
version: FAIRsharing.org: Open Targets; Open Targets; DOI: https://doi.org/10.25504/FAIRsharing.3f9n4y; Last edited: June 16, 2021, 1:17 p.m.; Last accessed: Jan 03 2022 7:06 p.m.
gene-disease association
metasource: Fairsharing.org
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phenotype
metasource: Fairsharing.org
version: FAIRsharing.org: Open Targets; Open Targets; DOI: https://doi.org/10.25504/FAIRsharing.3f9n4y; Last edited: June 16, 2021, 1:17 p.m.; Last accessed: Jan 03 2022 7:06 p.m.
rare disease
metasource: Fairsharing.org
version: FAIRsharing.org: Open Targets; Open Targets; DOI: https://doi.org/10.25504/FAIRsharing.3f9n4y; Last edited: June 16, 2021, 1:17 p.m.; Last accessed: Jan 03 2022 7:06 p.m.
target
metasource: Fairsharing.org
version: FAIRsharing.org: Open Targets; Open Targets; DOI: https://doi.org/10.25504/FAIRsharing.3f9n4y; Last edited: June 16, 2021, 1:17 p.m.; Last accessed: Jan 03 2022 7:06 p.m.
text mining
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version: FAIRsharing.org: Open Targets; Open Targets; DOI: https://doi.org/10.25504/FAIRsharing.3f9n4y; Last edited: June 16, 2021, 1:17 p.m.; Last accessed: Jan 03 2022 7:06 p.m.
proteomics resources
metasource: Nucleic Acid Research database catalogue
version: extracted_at: 2022-11-04T11:16:25.468657
drug discovery
metasource: bio.tools
version: extracted_at: 2022-11-04T11:25:09.130710
human genetics
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version: extracted_at: 2022-11-04T11:25:09.130710
functional genomics
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version: extracted_at: 2022-11-04T11:25:09.130710
pharmacogenomics
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version: extracted_at: 2022-11-04T11:25:09.130710
systems biology
metasource: bio.tools
version: extracted_at: 2022-11-04T11:25:09.130710
translational medicine
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version: extracted_at: 2022-11-04T11:25:09.130710
omics
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version: extracted_at: 2022-11-04T11:25:09.130710
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More detailed information about this field from each metasource.
abstract
metasource: Fairsharing.orgversion: FAIRsharing.org: Open Targets; Open Targets; DOI: https://doi.org/10.25504/FAIRsharing.3f9n4y; Last edited: June 16, 2021, 1:17 p.m.; Last accessed: Jan 03 2022 7:06 p.m.
approved drug
metasource: Fairsharing.orgversion: FAIRsharing.org: Open Targets; Open Targets; DOI: https://doi.org/10.25504/FAIRsharing.3f9n4y; Last edited: June 16, 2021, 1:17 p.m.; Last accessed: Jan 03 2022 7:06 p.m.
disease
metasource: Fairsharing.orgversion: FAIRsharing.org: Open Targets; Open Targets; DOI: https://doi.org/10.25504/FAIRsharing.3f9n4y; Last edited: June 16, 2021, 1:17 p.m.; Last accessed: Jan 03 2022 7:06 p.m.
disease phenotype
metasource: Fairsharing.orgversion: FAIRsharing.org: Open Targets; Open Targets; DOI: https://doi.org/10.25504/FAIRsharing.3f9n4y; Last edited: June 16, 2021, 1:17 p.m.; Last accessed: Jan 03 2022 7:06 p.m.
disease process modeling
metasource: Fairsharing.orgversion: FAIRsharing.org: Open Targets; Open Targets; DOI: https://doi.org/10.25504/FAIRsharing.3f9n4y; Last edited: June 16, 2021, 1:17 p.m.; Last accessed: Jan 03 2022 7:06 p.m.
gene report
metasource: Fairsharing.orgversion: FAIRsharing.org: Open Targets; Open Targets; DOI: https://doi.org/10.25504/FAIRsharing.3f9n4y; Last edited: June 16, 2021, 1:17 p.m.; Last accessed: Jan 03 2022 7:06 p.m.
gene-disease association
metasource: Fairsharing.orgversion: FAIRsharing.org: Open Targets; Open Targets; DOI: https://doi.org/10.25504/FAIRsharing.3f9n4y; Last edited: June 16, 2021, 1:17 p.m.; Last accessed: Jan 03 2022 7:06 p.m.
phenotype
metasource: Fairsharing.orgversion: FAIRsharing.org: Open Targets; Open Targets; DOI: https://doi.org/10.25504/FAIRsharing.3f9n4y; Last edited: June 16, 2021, 1:17 p.m.; Last accessed: Jan 03 2022 7:06 p.m.
rare disease
metasource: Fairsharing.orgversion: FAIRsharing.org: Open Targets; Open Targets; DOI: https://doi.org/10.25504/FAIRsharing.3f9n4y; Last edited: June 16, 2021, 1:17 p.m.; Last accessed: Jan 03 2022 7:06 p.m.
target
metasource: Fairsharing.orgversion: FAIRsharing.org: Open Targets; Open Targets; DOI: https://doi.org/10.25504/FAIRsharing.3f9n4y; Last edited: June 16, 2021, 1:17 p.m.; Last accessed: Jan 03 2022 7:06 p.m.
text mining
metasource: Fairsharing.orgversion: FAIRsharing.org: Open Targets; Open Targets; DOI: https://doi.org/10.25504/FAIRsharing.3f9n4y; Last edited: June 16, 2021, 1:17 p.m.; Last accessed: Jan 03 2022 7:06 p.m.
proteomics resources
metasource: Nucleic Acid Research database catalogueversion: extracted_at: 2022-11-04T11:16:25.468657
drug discovery
metasource: bio.toolsversion: extracted_at: 2022-11-04T11:25:09.130710
human genetics
metasource: bio.toolsversion: extracted_at: 2022-11-04T11:25:09.130710
functional genomics
metasource: bio.toolsversion: extracted_at: 2022-11-04T11:25:09.130710
pharmacogenomics
metasource: bio.toolsversion: extracted_at: 2022-11-04T11:25:09.130710
systems biology
metasource: bio.toolsversion: extracted_at: 2022-11-04T11:25:09.130710
translational medicine
metasource: bio.toolsversion: extracted_at: 2022-11-04T11:25:09.130710
omics
metasource: bio.toolsversion: extracted_at: 2022-11-04T11:25:09.130710
abstract approved drug disease disease phenotype disease process modeling gene report gene-disease association phenotype rare disease target text mining proteomics resources drug discovery human genetics functional genomics pharmacogenomics systems biology translational medicine omics
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