Open Targets Genetics
Names
More detailed information about this field from each metasource.
Open Targets Genetics
metasource: Nucleic Acid Research database catalogue
version: extracted_at: 2022-11-04T11:16:25.468657
metasource: bio.tools
version: extracted_at: 2022-11-04T11:25:09.130710
open_targets_genetics
metasource: bio.tools
version: extracted_at: 2022-11-04T11:25:09.130710
Names
More detailed information about this field from each metasource.
Open Targets Genetics
metasource: Nucleic Acid Research database catalogueversion: extracted_at: 2022-11-04T11:16:25.468657
metasource: bio.tools
version: extracted_at: 2022-11-04T11:25:09.130710
open_targets_genetics
metasource: bio.toolsversion: extracted_at: 2022-11-04T11:25:09.130710
Other names: open_targets_genetics
Names
More detailed information about this field from each metasource.
Open Targets Genetics
metasource: Nucleic Acid Research database catalogueversion: extracted_at: 2022-11-04T11:16:25.468657
metasource: bio.tools
version: extracted_at: 2022-11-04T11:25:09.130710
open_targets_genetics
metasource: bio.toolsversion: extracted_at: 2022-11-04T11:25:09.130710
Drug targets prioritised from genetic data
Description
More detailed information about this field from each metasource.
Drug targets prioritised from genetic data
metasource: Nucleic Acid Research database catalogueversion: extracted_at: 2022-11-04T11:16:25.468657
Open Targets Genetics is a robust tool highlighting variant-centric statistical evidence to allow both prioritisation of candidate causal variants at trait-associated loci and identification of potential drug targets. The portal aggregates and merges genetic associations curated from both literature and newly-derived loci from UK Biobank, which contains functional genomics data (e.g. chromatin conformation, chromatin interactions) and quantitative trait loci (eQTLs and pQTLs). Statistical fine-mapping methods are applied across thousands of trait-associated loci to resolve association signals and to link each variant to its proximal and distal target gene(s), using a single evidence score. Integrated cross-trait colocalisation analyses and linking to detailed pharmaceutical compounds extend the capability of Open Targets Genetics to explore drug repositioning opportunities and shared genetic architecture.
metasource: bio.toolsversion: extracted_at: 2022-11-04T11:25:09.130710
Webpage:
https://genetics.opentargets.org/Webpage
More detailed information about this field from each metasource.
https://genetics.opentargets.org/
metasource: Nucleic Acid Research database catalogueversion: extracted_at: 2022-11-04T11:16:25.468657
https://genetics.opentargets.org
metasource: bio.toolsversion: extracted_at: 2022-11-04T11:25:09.130710
Licence:
Name: Apache-2.0Licence name
More detailed information about this field from each metasource.
Publications:
Publications
More detailed information about this field from each metasource.
Open Targets Genetics: systematic identification of trait-associated genes using large-scale genetics and functional genomics
PMID: 33045747
metasource: bio.tools
version: extracted_at: 2022-11-04T11:25:09.130710
An open approach to systematically prioritize causal variants and genes at all published human GWAS trait-associated loci
PMID: 34711957
metasource: bio.tools
version: extracted_at: 2022-11-04T11:25:09.130710
https://doi.org/10.1093/nar/gkaa840
metasource: Nucleic Acid Research database catalogue
version: extracted_at: 2022-11-04T11:16:25.468657
Publications
More detailed information about this field from each metasource.
Open Targets Genetics: systematic identification of trait-associated genes using large-scale genetics and functional genomics
PMID: 33045747
metasource: bio.tools
version: extracted_at: 2022-11-04T11:25:09.130710
An open approach to systematically prioritize causal variants and genes at all published human GWAS trait-associated loci
PMID: 34711957
metasource: bio.tools
version: extracted_at: 2022-11-04T11:25:09.130710
https://doi.org/10.1093/nar/gkaa840
metasource: Nucleic Acid Research database catalogueversion: extracted_at: 2022-11-04T11:16:25.468657
-
Open Targets Genetics: systematic identification of trait-associated genes using large-scale genetics and functional genomics
PubMed citations: 31.
31 articles citing: Open Targets Genetics: systematic identification of trait-associated genes using large-scale genetics and functional genomics
The landscape of GWAS validation; systematic review identifying 309 validated non-coding variants across 130 human diseases. PMID:35365203
SMetABF: A rapid algorithm for Bayesian GWAS meta-analysis with a large number of studies included. PMID:35286307
Genetically regulated multi-omics study for symptom clusters of posttraumatic stress disorder highlights pleiotropy with hematologic and cardio-metabolic traits. PMID:35241783
Integrating single-cell sequencing data with GWAS summary statistics reveals CD16+monocytes and memory CD8+T cells involved in severe COVID-19. PMID:35172892
Population-based genetic effects for developmental stuttering. PMID:35047858
Fine mapping with epigenetic information and 3D structure. PMID:35022890
Maturation and application of phenome-wide association studies. PMID:34991903
Identification of Recessively Inherited Genetic Variants Potentially Linked to Pancreatic Cancer Risk. PMID:34926279
CCR5 and Biological Complexity: The Need for Data Integration and Educational Materials to Address Genetic/Biological Reductionism at the Interface of Ethical, Legal, and Social Implications. PMID:34925370
Genome-wide gene-air pollution interaction analysis of lung function in 300,000 individuals. PMID:34923368
Targeted analysis of genomic regions enriched in African ancestry reveals novel classical HLA alleles associated with asthma in Southwestern Europeans. PMID:34880287
What makes a good prediction? Feature importance and beginning to open the black box of machine learning in genetics. PMID:34862561
Priority index: database of genetic targets in immune-mediated disease. PMID:34751399
Integrative analysis of the plasma proteome and polygenic risk of cardiometabolic diseases. PMID:34750571
MC3R links nutritional state to childhood growth and the timing of puberty. PMID:34732894
HIF-1α Pulmonary Phenotype Wide Association Study Unveils a Link to Inflammatory Airway Conditions. PMID:34621299
A compendium of uniformly processed human gene expression and splicing quantitative trait loci. PMID:34493866
A proteome-wide genetic investigation identifies several SARS-CoV-2-exploited host targets of clinical relevance. PMID:34402426
Integrative genomic analyses identify susceptibility genes underlying COVID-19 hospitalization. PMID:34315903
Advancing the use of genome-wide association studies for drug repurposing. PMID:34302145
Segregation Analysis of Genotyped and Family-Phased, Long Range MHC Classical Class I and Class II Haplotypes in 5 Families With Type 1 Diabetes Proband in the United Arab Emirates. PMID:34276777
The role of genetic polymorphisms in endolysosomal ion channels TPC2 and P2RX4 in cancer pathogenesis, prognosis, and diagnosis: a genetic association in the UK Biobank. PMID:34253731
Immunotherapy-Mediated Thyroid Dysfunction: Genetic Risk and Impact on Outcomes with PD-1 Blockade in Non-Small Cell Lung Cancer. PMID:34244291
Mapping the human genetic architecture of COVID-19. PMID:34237774
Variants in BANK1 are associated with lupus nephritis of European ancestry. PMID:34127828
Association of Novel Locus With Rheumatic Heart Disease in Black African Individuals: Findings From the RHDGen Study. PMID:34106200
Genetics of symptom remission in outpatients with COVID-19. PMID:34035401
Triangulating Molecular Evidence to Prioritize Candidate Causal Genes at Established Atopic Dermatitis Loci. PMID:33901562
The Implications of ncRNAs in the Development of Human Diseases. PMID:33668203
The 2021 Nucleic Acids Research database issue and the online molecular biology database collection. PMID:33396976
Open Targets Platform: supporting systematic drug-target identification and prioritisation. PMID:33196847 -
An open approach to systematically prioritize causal variants and genes at all published human GWAS trait-associated loci
PubMed citations: 5.
5 articles citing: An open approach to systematically prioritize causal variants and genes at all published human GWAS trait-associated loci
Genome-Wide Association Study-Guided Exome Rare Variant Burden Analysis Identifies IL1R1 and CD3E as Potential Autoimmunity Risk Genes for Celiac Disease. PMID:35237542
The Applications of Single-Cell RNA Sequencing in Atherosclerotic Disease. PMID:35211529
Fine mapping with epigenetic information and 3D structure. PMID:35022890
Dissecting the Shared Genetic Architecture of Suicide Attempt, Psychiatric Disorders, and Known Risk Factors. PMID:34861974
A proteome-wide genetic investigation identifies several SARS-CoV-2-exploited host targets of clinical relevance. PMID:34402426 - https://doi.org/10.1093/nar/gkaa840
Tags:
Tags
More detailed information about this field from each metasource.
drug discovery
metasource: bio.tools
version: extracted_at: 2022-11-04T11:25:09.130710
human genetics
metasource: bio.tools
version: extracted_at: 2022-11-04T11:25:09.130710
functional genomics
metasource: bio.tools
version: extracted_at: 2022-11-04T11:25:09.130710
Tags
More detailed information about this field from each metasource.
drug discovery
metasource: bio.toolsversion: extracted_at: 2022-11-04T11:25:09.130710
human genetics
metasource: bio.toolsversion: extracted_at: 2022-11-04T11:25:09.130710
functional genomics
metasource: bio.toolsversion: extracted_at: 2022-11-04T11:25:09.130710
drug discovery human genetics functional genomics
Need help integrating and/or managing biomedical data?