Genetic Diversity and Low Therapeutic Impact of Variant-Specific Markers in HIV-1 Pol Proteins.
PMID:35910645
Prevalence and Evolution of Transmitted Human Immunodeficiency Virus Drug Resistance in Belgium Between 2013 and 2019.
PMID:35794938
HIV-1 Drug Resistance Assay Using Ion Torrent Next Generation Sequencing and On-Instrument End-to-End Analysis Software.
PMID:35699434
Viruses Previously Identified in Brazil as Belonging to HIV-1 CRF72_BF1 Represent Two Closely Related Circulating Recombinant Forms, One of Which, Designated CRF122_BF1, Is Also Circulating in Spain.
PMID:35694315
Spectrum of Atazanavir-Selected Protease Inhibitor-Resistance Mutations.
PMID:35631067
Islatravir Has a High Barrier to Resistance and Exhibits a Differentiated Resistance Profile from Approved Nucleoside Reverse Transcriptase Inhibitors (NRTIs).
PMID:35546110
Public availability of HIV-1 drug resistance sequence and treatment data: a systematic review.
PMID:35544100
HIV-1 non-B resistance mutations and natural polymorphisms to integrase strand transfer inhibitors in recently diagnosed patients in Gabon, Central Africa.
PMID:35474382
Consistent Quantification of Complex Dynamics via a Novel Statistical Complexity Measure.
PMID:35455168
Pretreatment Human Immunodeficiency Virus (HIV) Drug Resistance Among Treatment-Naive Infants Newly Diagnosed With HIV in 2016 in Namibia: Results of a Nationally Representative Study.
PMID:35434174
Potential Resistance of SARS-CoV-2 Main Protease (Mpro) against Protease Inhibitors: Lessons Learned from HIV-1 Protease.
PMID:35408866
First report of computational protein-ligand docking to evaluate susceptibility to HIV integrase inhibitors in HIV-infected Iranian patients.
PMID:35368742
Analyses of HIV proteases variants at the threshold of viability reveals relationships between processing efficiency and fitness.
PMID:35299788
Coronavirus Resistance Database (CoV-RDB): SARS-CoV-2 susceptibility to monoclonal antibodies, convalescent plasma, and plasma from vaccinated persons.
PMID:35263335
Achieving virological control in pan-resistant HIV-1 infection: A case series.
PMID:35255457
Antiretroviral Imprints and Genomic Plasticity of HIV-1 pol in Non-clade B: Implications for Treatment.
PMID:35222310
Management of a human immunodeficiency virus case with discordant antiviral drug resistance profiles in cerebrospinal fluid compared with plasma: a case report.
PMID:35164871
An Android-Based Mobile App (ARVPredictor) for the Detection of HIV Drug-Resistance Mutations and Treatment at the Point of Care: Development Study.
PMID:35107425
Limits to detecting epistasis in the fitness landscape of HIV.
PMID:35041711
Statewide Longitudinal Trends in Transmitted HIV-1 Drug Resistance in Rhode Island, USA.
PMID:34988256
Why the HIV Reservoir Never Runs Dry: Clonal Expansion and the Characteristics of HIV-Infected Cells Challenge Strategies to Cure and Control HIV Infection.
PMID:34960781
Adherence, resistance, and viral suppression on dolutegravir in sub-Saharan Africa: implications for the TLD era.
PMID:34848579
Genetic Diversity and Acquired Drug Resistance Mutations Detected by Deep Sequencing in Virologic Failures among Antiretroviral Treatment Experienced Human Immunodeficiency Virus-1 Patients in a Pastoralist Region of Ethiopia.
PMID:34819737
Who's slipping through the cracks? A comprehensive individual, clinical and health system characterization of people with virological failure on first-line HIV treatment in Uganda and South Africa.
PMID:34755438
Deep sequencing of HIV-1 reveals extensive subtype variation and drug resistance after failure of first-line antiretroviral regimens in Nigeria.
PMID:34741609
High prevalence of HIV-1 transmitted drug resistance and factors associated with time to virological failure and viral suppression in Taiwan.
PMID:34648632
MDM-TASK-web: MD-TASK and MODE-TASK web server for analyzing protein dynamics.
PMID:34589183
Revealing the Mutation Patterns of Drug-Resistant Reverse Transcriptase Variants of Human Immunodeficiency Virus through Proteochemometric Modeling.
PMID:34572515
Development of Human Immunodeficiency Virus Type 1 Resistance to 4'-Ethynyl-2-Fluoro-2'-Deoxyadenosine Starting with Wild-Type or Nucleoside Reverse Transcriptase Inhibitor-Resistant Strains.
PMID:34516245
Comparing mutational pathways to lopinavir resistance in HIV-1 subtypes B versus C.
PMID:34491984
Phylogenetic and Drug-Resistance Analysis of HIV-1 Sequences From an Extensive Paediatric HIV-1 Outbreak in Larkana, Pakistan.
PMID:34484134
Revertant mutation V48G alters conformational dynamics of highly drug resistant HIV protease PRS17.
PMID:34419931
Molecular epidemiology and HIV-1 variant evolution in Poland between 2015 and 2019.
PMID:34400726
HIV-1 Drug Resistance and Genetic Transmission Networks Among MSM Failing Antiretroviral Therapy in South China 2014-2019.
PMID:34377002
Prediction of HIV drug resistance based on the 3D protein structure: Proposal of molecular field mapping.
PMID:34347839
Identifying and Characterizing Trans Women in the Swiss HIV Cohort Study as an Epidemiologically Distinct Risk Group.
PMID:34282827
RHIVDB: A Freely Accessible Database of HIV Amino Acid Sequences and Clinical Data of Infected Patients.
PMID:34178036
HIV Protease: Historical Perspective and Current Research.
PMID:34066370
Systematic screening of viral and human genetic variation identifies antiretroviral resistance and immune escape link.
PMID:34061023
Emergence of Human Immunodeficiency Virus-1 Drug Resistance During the 3-Month World Health Organization-Recommended Enhanced Adherence Counseling Period in the CART-1 Cohort Study.
PMID:34046513
Longitudinal typing of molecular HIV clusters in a statewide epidemic.
PMID:34033589
HIV Drug Resistance and Transmission Networks Among a Justice-Involved Population at the Time of Community Reentry in Washington, D.C.
PMID:33896212
Guidelines are needed for studies of pre-treatment HIV drug resistance: a methodological study.
PMID:33874897
Hepatitis B virus resistance to tenofovir: fact or fiction? A systematic literature review and structural analysis of drug resistance mechanisms.
PMID:33869791
Priority Intervention Targets Identified Using an In-Depth Sampling HIV Molecular Network in a Non-Subtype B Epidemics Area.
PMID:33854982
Short Communication: Integrase Strand Transfer Inhibitors Drug Resistance Mutations in Puerto Rico HIV-Positive Individuals.
PMID:33800269
Drug Design Strategies to Avoid Resistance in Direct-Acting Antivirals and Beyond.
PMID:33410674
Evolution of drug resistance in HIV protease.
PMID:33375936
Absence of Integrase Inhibitor-Associated Resistance Among Antiretroviral Therapy-Naïve HIV-1-Infected Adults in Guangdong Province, China, in 2018.
PMID:33324078
Identification of an Antiretroviral Small Molecule That Appears To Be a Host-Targeting Inhibitor of HIV-1 Assembly.
PMID:33148797
Predictors of Virological Failure and Time to Viral Suppression of First-Line Integrase Inhibitor-Based Antiretroviral Treatment.
PMID:33095848
Contrast-FEL-A Test for Differences in Selective Pressures at Individual Sites among Clades and Sets of Branches.
PMID:33064823
Differences in human immunodeficiency virus-1C viral load and drug resistance mutation between plasma and cerebrospinal fluid in patients with human immunodeficiency virus-associated cryptococcal meningitis in Botswana.
PMID:33031315
Virologic suppression in patients with a documented M184V/I mutation based on the number of active agents in the antiretroviral regimen.
PMID:33014372
Few amino acid signatures distinguish HIV-1 subtype B pandemic and non-pandemic strains.
PMID:32960906
High nonnucleoside reverse transcriptase inhibitor resistance levels in HIV-1-infected Zambian mother-infant pairs.
PMID:32889853
Raltegravir use and outcomes among children and adolescents living with HIV in the IeDEA global consortium.
PMID:32722897
Validation of Variant Assembly Using HAPHPIPE with Next-Generation Sequence Data from Viruses.
PMID:32674515
Targeting HIV-1 RNase H: N'-(2-Hydroxy-benzylidene)-3,4,5-Trihydroxybenzoylhydrazone as Selective Inhibitor Active against NNRTIs-Resistant Variants.
PMID:32640577
A de novo approach to inferring within-host fitness effects during untreated HIV-1 infection.
PMID:32492061
Drug Resistance Prediction Using Deep Learning Techniques on HIV-1 Sequence Data.
PMID:32438586
A near full-length HIV-1 genome from 1966 recovered from formalin-fixed paraffin-embedded tissue.
PMID:32430331
An Innovative Sequence-to-Structure-Based Approach to Drug Resistance Interpretation and Prediction: The Use of Molecular Interaction Fields to Detect HIV-1 Protease Binding-Site Dissimilarities.
PMID:32411655
HIV-1 molecular epidemiology and drug resistance-associated mutations among treatment-naïve blood donors in China.
PMID:32371875
Diverse HCV Strains And HIV URFS Identified Amongst People Who Inject Drugs In India.
PMID:32350342
Massively multiplexed nucleic acid detection with Cas13.
PMID:32349121
Prevalence of acquired drug resistance mutations in antiretroviral- experiencing subjects from 2012 to 2017 in Hunan Province of central South China.
PMID:32183889
Discordance between Etravirine Phenotype and Genotype-Based Predicted Phenotype for Subtype C HIV-1 from First-Line Antiretroviral Therapy Failures in South Africa.
PMID:32071061
Multi-state design of flexible proteins predicts sequences optimal for conformational change.
PMID:32032348
A cross-sectional study to characterize local HIV-1 dynamics in Washington, DC using next-generation sequencing.
PMID:32029767
A Computational Approach for the Prediction of Treatment History and the Effectiveness or Failure of Antiretroviral Therapy.
PMID:31979356
Pre-treatment HIV-drug resistance associated with virologic outcome of first-line NNRTI-antiretroviral therapy: A cohort study in Kenya.
PMID:31956856
HIV-1 Unique Recombinant Forms Identified in Slovenia and Their Characterization by Near Full-Length Genome Sequencing.
PMID:31947872
Highly drug-resistant HIV-1 protease reveals decreased intra-subunit interactions due to clusters of mutations.
PMID:31920003
The ability of single genes vs full genomes to resolve time and space in outbreak analysis.
PMID:31878875
Characterizing Protein-Ligand Binding Using Atomistic Simulation and Machine Learning: Application to Drug Resistance in HIV-1 Protease.
PMID:31877249
Elucidating molecular interactions of L-nucleotides with HIV-1 reverse transcriptase and mechanism of M184V-caused drug resistance.
PMID:31872074
High levels of pretreatment and acquired HIV drug resistance in Nicaragua: results from the first nationally representative survey, 2016.
PMID:31860167
Moderately High Tenofovir Diphosphate in Dried Blood Spots Indicates Drug Resistance in Viremic Persons Living with HIV.
PMID:31750768
Epistasis and entrenchment of drug resistance in HIV-1 subtype B.
PMID:31591964
Prevalence and Correlates of Pre-Treatment HIV Drug Resistance among HIV-Infected Children in Ethiopia.
PMID:31546824
MiDRMpol: A High-Throughput Multiplexed Amplicon Sequencing Workflow to Quantify HIV-1 Drug Resistance Mutations against Protease, Reverse Transcriptase, and Integrase Inhibitors.
PMID:31480341
Transmission Dynamics of HIV Subtype A in Tel Aviv, Israel: Implications for HIV Spread and Eradication.
PMID:31363777
Picomolar to Micromolar: Elucidating the Role of Distal Mutations in HIV-1 Protease in Conferring Drug Resistance.
PMID:31361460
NNRTI-induced HIV-1 protease-mediated cytotoxicity induces rapid death of CD4 T cells during productive infection and latency reversal.
PMID:31242909
A MiSeq-HyDRA platform for enhanced HIV drug resistance genotyping and surveillance.
PMID:31222149
Nonnucleoside Reverse Transcriptase Inhibitor Hypersusceptibility and Resistance by Mutation of Residue 181 in HIV-1 Reverse Transcriptase.
PMID:31160281
An Evolutionary Model-Based Approach To Quantify the Genetic Barrier to Drug Resistance in Fast-Evolving Viruses and Its Application to HIV-1 Subtypes and Integrase Inhibitors.
PMID:31109980
Avirulins, a Novel Class of HIV-1 Reverse Transcriptase Inhibitors Effective in the Female Reproductive Tract Mucosa.
PMID:31052477
Role of co-expressed APOBEC3F and APOBEC3G in inducing HIV-1 drug resistance.
PMID:31025011
Mutations in the HIV-1 envelope glycoprotein can broadly rescue blocks at multiple steps in the virus replication cycle.
PMID:30975760
Low rates of nucleoside reverse transcriptase inhibitor and nonnucleoside reverse transcriptase inhibitor drug resistance in Botswana.
PMID:30946161
PERSIA for Direct Fluorescence Measurements of Transcription, Translation, and Enzyme Activity in Cell-Free Systems.
PMID:30920800
The Utility of Efavirenz-based Prophylaxis Against HIV Infection. A Systems Pharmacological Analysis.
PMID:30918485
High predictive efficacy of integrase strand transfer inhibitors in perinatally HIV-1-infected African children in therapeutic failure of first- and second-line antiretroviral drug regimens recommended by the WHO.
PMID:30891603
Resistance Analysis of Bictegravir-Emtricitabine-Tenofovir Alafenamide in HIV-1 Treatment-Naive Patients through 48 Weeks.
PMID:30803969
Maintenance of Viral Suppression after Optimization Therapy from Etravirine Plus Raltegravir to Rilpivirine Plus Dolutegravir in HIV-1-Infected Patients.
PMID:30798670
Constrained Mutational Sampling of Amino Acids in HIV-1 Protease Evolution.
PMID:30721995
Increased predominance of HIV-1 CRF01_AE and its recombinants in the Philippines.
PMID:30676308
First-line HIV treatment failures in non-B subtypes and recombinants: a cross-sectional analysis of multiple populations in Uganda.
PMID:30670037
Prevalence and persistence of transmitted drug resistance mutations in the German HIV-1 Seroconverter Study Cohort.
PMID:30650082
Structural Adaptation of Darunavir Analogues against Primary Mutations in HIV-1 Protease.
PMID:30543749
Characterisation of HIV-1 transmission clusters and drug-resistant mutations in Denmark, 2004 to 2016.
PMID:30401010
Genetic divergence of HIV-1 B subtype in Italy over the years 2003-2016 and impact on CTL escape prevalence.
PMID:30356083
A Computational Approach for the Prediction of HIV Resistance Based on Amino Acid and Nucleotide Descriptors.
PMID:30355996
Clinical and Virologic Outcomes Following Initiation of Antiretroviral Therapy Among Seroconverters in the Microbicide Trials Network-020 Phase III Trial of the Dapivirine Vaginal Ring.
PMID:30346511
Analysis of drug resistance in HIV protease.
PMID:30343664
Antiretroviral resistance, genotypic characterization and origin of Human Immunodeficiency Virus among the infected wives of Intravenous drug users in Manipur.
PMID:30315192
The dawn of precision medicine in HIV: state of the art of pharmacotherapy.
PMID:30234392
New antiretroviral agent use affects prevalence of HIV drug resistance in clinical care populations.
PMID:30134298
Structural Implications of Genotypic Variations in HIV-1 Integrase From Diverse Subtypes.
PMID:30116231
Geographically-stratified HIV-1 group M pol subtype and circulating recombinant form sequences.
PMID:30063225
HIV-1 proviral landscapes distinguish posttreatment controllers from noncontrollers.
PMID:30024859
Modeling Cumulative Biological Phenomena with Suppes-Bayes Causal Networks.
PMID:30013303
A systematic assessment of the availability and clinical drug information coverage of machine-readable clinical drug data sources for building knowledge translation products.
PMID:29982512
Within-patient mutation frequencies reveal fitness costs of CpG dinucleotides and drastic amino acid changes in HIV.
PMID:29953449
HIV transmission in discordant couples in Africa in the context of antiretroviral therapy availability.
PMID:29762171
Field-deployable viral diagnostics using CRISPR-Cas13.
PMID:29700266
HIV Resistance Prediction to Reverse Transcriptase Inhibitors: Focus on Open Data.
PMID:29671808
Testing for Marginal Linear Effects in Quantile Regression.
PMID:29576736
Frequent cross-resistance to rilpivirine among subtype C HIV-1 from first-line antiretroviral therapy failures in South Africa.
PMID:29566538
Incomplete inhibition of HIV infection results in more HIV infected lymph node cells by reducing cell death.
PMID:29555018
Implication of First-Line Antiretroviral Therapy Choice on Second-Line Options.
PMID:29255731
Ex-vivo antiretroviral potency of newer integrase strand transfer inhibitors cabotegravir and bictegravir in HIV type 1 non-B subtypes.
PMID:29239896
The L33F darunavir resistance mutation acts as a molecular anchor reducing the flexibility of the HIV-1 protease 30s and 80s loops.
PMID:29124158
Analysis of the conformations of the HIV-1 protease from a large crystallographic data set.
PMID:29124093
Newly Acquired Infection With Multidrug-Resistant HIV-1 in a Patient Adherent to Preexposure Prophylaxis.
PMID:29076941
Prevalence of Pre-antiretroviral-Treatment Drug Resistance by Gender, Age, and Other Factors in HIV-Infected Individuals Initiating Therapy in Kenya, 2013-2014.
PMID:29040633
Drug resistance patterns following pharmacy stock shortage in Nigerian Antiretroviral Treatment Program.
PMID:29029637
Elucidating the Interdependence of Drug Resistance from Combinations of Mutations.
PMID:28915040
Adaptive HIV-1 evolutionary trajectories are constrained by protein stability.
PMID:28852572
Stimulus-responsive viral vectors for controlled delivery of therapeutics.
PMID:28842318
Improving fold resistance prediction of HIV-1 against protease and reverse transcriptase inhibitors using artificial neural networks.
PMID:28810826
High level of HIV-1 drug resistance mutations in patients with unsuppressed viral loads in rural northern South Africa.
PMID:28750647
Potential for immune-driven viral polymorphisms to compromise antiretroviral-based preexposure prophylaxis for prevention of HIV-1 infection.
PMID:28650381
Decreased emergence of HIV-1 drug resistance mutations in a cohort of Ugandan women initiating option B+ for PMTCT.
PMID:28562612
Mutational Correlates of Virological Failure in Individuals Receiving a WHO-Recommended Tenofovir-Containing First-Line Regimen: An International Collaboration.
PMID:28365230
Virological Outcomes of Second-line Protease Inhibitor-Based Treatment for Human Immunodeficiency Virus Type 1 in a High-Prevalence Rural South African Setting: A Competing-Risks Prospective Cohort Analysis.
PMID:28329393
High Rates of Transmission of Drug-resistant HIV in Aruba Resulting in Reduced Susceptibility to the WHO Recommended First-line Regimen in Nearly Half of Newly Diagnosed HIV-infected Patients.
PMID:28329390
GEAR: A database of Genomic Elements Associated with drug Resistance.
PMID:28294141
NucAmino: a nucleotide to amino acid alignment optimized for virus gene sequences.
PMID:28249562
Prevalence of Transmitted Drug-Resistance Mutations and Polymorphisms in HIV-1 Reverse Transcriptase, Protease, and gp41 Sequences Among Recent Seroconverters in Southern Poland.
PMID:28167814
Characterization of the Drug Resistance Profiles of Patients Infected with CRF07_BC Using Phenotypic Assay and Ultra-Deep Pyrosequencing.
PMID:28107423
Glycan Alteration Imparts Cellular Resistance to a Membrane-Lytic Anticancer Peptide.
PMID:28089756
HIV drug resistance testing among patients failing second line antiretroviral therapy. Comparison of in-house and commercial sequencing.
PMID:27894862
Quantitative evaluation of the antiretroviral efficacy of dolutegravir.
PMID:27882352
Declining trend in transmitted drug resistance detected in a prospective cohort study of acute HIV infection in Bangkok, Thailand.
PMID:27802846
Epistasis and Pleiotropy Affect the Modularity of the Genotype-Phenotype Map of Cross-Resistance in HIV-1.
PMID:27678053
Genome-Wide Association Study of HIV Whole Genome Sequences Validated using Drug Resistance.
PMID:27677172
A simple and cost-saving phenotypic drug susceptibility testing of HIV-1.
PMID:27640883
Automated prediction of HIV drug resistance from genotype data.
PMID:27586700
Global Comparison of Drug Resistance Mutations After First-Line Antiretroviral Therapy Across Human Immunodeficiency Virus-1 Subtypes.
PMID:27419147
Surveillance of HIV Transmitted Drug Resistance in Latin America and the Caribbean: A Systematic Review and Meta-Analysis.
PMID:27355626
Treatment Outcomes and Resistance Patterns of Children and Adolescents on Second-Line Antiretroviral Therapy in Asia.
PMID:27355415
The global spread of HIV-1 subtype B epidemic.
PMID:27262355
Exploiting Genetic Interference for Antiviral Therapy.
PMID:27149616
HIV-1 Protease, Reverse Transcriptase, and Integrase Variation.
PMID:27099321
Rapid and Simultaneous Detection of Major Drug Resistance Mutations in Reverse Transcriptase Gene for HIV-1 CRF01_AE, CRF07_BC and Subtype B in China Using Sequenom MassARRAY® System.
PMID:27092551
Improving Viral Protease Inhibitors to Counter Drug Resistance.
PMID:27090931
An adaptive resampling test for detecting the presence of significant predictors.
PMID:27073292
Q148N, a Novel Integrase Inhibitor Resistance Mutation Associated with Low-Level Reduction in Elvitegravir Susceptibility.
PMID:27009474
Exploiting HIV-1 protease and reverse transcriptase cross-resistance information for improved drug resistance prediction by means of multi-label classification.
PMID:26933450
More effective drugs lead to harder selective sweeps in the evolution of drug resistance in HIV-1.
PMID:26882502
Genetic Variability of HIV-1 for Drug Resistance Assay Development.
PMID:26875985
Mutations Related to Antiretroviral Resistance Identified by Ultra-Deep Sequencing in HIV-1 Infected Children under Structured Interruptions of HAART.
PMID:26807922
Prevalence of K65R in patients treated with tenofovir disoproxil fumarate: recommendations based on the Frankfurt HIV Cohort Study Resistance Database (FHCS-RD).
PMID:26746222
Structural studies on molecular mechanisms of Nelfinavir resistance caused by non-active site mutation V77I in HIV-1 protease.
PMID:26695135
Identifying representative drug resistant mutants of HIV.
PMID:26678327
HIV Drug Resistance Surveillance in Honduras after a Decade of Widespread Antiretroviral Therapy.
PMID:26558396
Lessons from Ebola: Improving infectious disease surveillance to inform outbreak management.
PMID:26424572
Collaborative Effort for a Centralized Worldwide Tuberculosis Relational Sequencing Data Platform.
PMID:26409275
A Population-Structured HIV Epidemic in Israel: Roles of Risk and Ethnicity.
PMID:26302493
Global Database-Driven Assessment of HIV-1 Adaptation to the Immune Repertoires of Human Populations.
PMID:26246562
Genetic Consequences of Antiviral Therapy on HIV-1.
PMID:26170895
Development of Nevirapine Resistance in Children Exposed to the Prevention of Mother-to-Child HIV-1 Transmission Programme in Maputo, Mozambique.
PMID:26161559
Trends in Prevalence of HIV-1 Drug Resistance in a Public Clinic in Maputo, Mozambique.
PMID:26151752
Comparison of genotypic and virtual phenotypic drug resistance interpretations with laboratory-based phenotypes among CRF01_AE and subtype B HIV-infected individuals.
PMID:26147742
Statistical learning and selective inference.
PMID:26100887
Transmitted Drug Resistance Mutations in Antiretroviral-Naïve Injection Drug Users with Chronic HIV-1 Infection in Iran.
PMID:25962088
Genetic Changes in HIV-1 Gag-Protease Associated with Protease Inhibitor-Based Therapy Failure in Pediatric Patients.
PMID:25919760
HIV-1 subtypes and drug resistance profiles in a cohort of heterosexual patients in Istanbul, Turkey.
PMID:25916350
A Functional Interplay between Human Immunodeficiency Virus Type 1 Protease Residues 77 and 93 Involved in Differential Regulation of Precursor Autoprocessing and Mature Protease Activity.
PMID:25893662
HIV-1 diversity in an antiretroviral treatment naïve cohort from Bushbuckridge, Mpumalanga Province, South Africa.
PMID:25889106
Geographic and temporal trends in the molecular epidemiology and genetic mechanisms of transmitted HIV-1 drug resistance: an individual-patient- and sequence-level meta-analysis.
PMID:25849352
Lopinavir/Ritonavir Monotherapy as Second-line Antiretroviral Treatment in Resource-Limited Settings: Week 104 Analysis of AIDS Clinical Trials Group (ACTG) A5230.
PMID:25694653
Data-intensive analysis of HIV mutations.
PMID:25652056
Viral Genetic Diversity and Polymorphisms in a Cohort of HIV-1-Infected Patients Eligible for Initiation of Antiretroviral Therapy in Abuja, Nigeria.
PMID:25582324
A SIGNIFICANCE TEST FOR THE LASSO.
PMID:25574062
Cross-clade simultaneous HIV drug resistance genotyping for reverse transcriptase, protease, and integrase inhibitor mutations by Illumina MiSeq.
PMID:25533166
Defective hydrophobic sliding mechanism and active site expansion in HIV-1 protease drug resistant variant Gly48Thr/Leu89Met: mechanisms for the loss of saquinavir binding potency.
PMID:25513833
The HIV mutation browser: a resource for human immunodeficiency virus mutagenesis and polymorphism data.
PMID:25474213
Molecular mechanisms and design principles for promiscuous inhibitors to avoid drug resistance: lessons learned from HIV-1 protease inhibition.
PMID:25410041
Estimating HIV-1 fitness characteristics from cross-sectional genotype data.
PMID:25375675
Structural basis and distal effects of Gag substrate coevolution in drug resistance to HIV-1 protease.
PMID:25355911
The lysine 65 residue in HIV-1 reverse transcriptase function and in nucleoside analog drug resistance.
PMID:25341667
A "fuzzy"-logic language for encoding multiple physical traits in biomolecules.
PMID:25311857
A uniquely prevalent nonnucleoside reverse transcriptase inhibitor resistance mutation in Russian subtype A HIV-1 viruses.
PMID:25259833
Low-frequency NNRTI-resistant HIV-1 variants and relationship to mutational load in antiretroviral-naïve subjects.
PMID:25256391
Drug susceptibility prediction against a panel of drugs using kernelized Bayesian multitask learning.
PMID:25161247
Prediction of HIV drug resistance from genotype with encoded three-dimensional protein structure.
PMID:25081370
Identifying selection in the within-host evolution of influenza using viral sequence data.
PMID:25080215
Prevalence and virologic consequences of transmitted HIV-1 drug resistance in Uganda.
PMID:24960249
Sparse Representation for Prediction of HIV-1 Protease Drug Resistance.
PMID:24910813
Prevalence of WHO transmitted drug resistance mutations by deep sequencing in antiretroviral-naïve subjects in Hunan Province, China.
PMID:24896087
The HIVToolbox 2 web system integrates sequence, structure, function and mutation analysis.
PMID:24886930
The contribution of viral genotype to plasma viral set-point in HIV infection.
PMID:24789308
Phylogenetic evidence of HIV-1 sequence evolution in subjects with persistent low-level viraemia.
PMID:24699164
Natural polymorphisms and unusual mutations in HIV-1 protease with potential antiretroviral resistance: a bioinformatic analysis.
PMID:24629078
Profile of darunavir in the treatment of HIV-infected pediatric and adolescent patients.
PMID:24600277
Residual viremia in an RT-SHIV rhesus macaque HAART model marked by the presence of a predominant plasma clone and a lack of viral evolution.
PMID:24505452
Southern African Treatment Resistance Network (SATuRN) RegaDB HIV drug resistance and clinical management database: supporting patient management, surveillance and research in southern Africa.
PMID:24504151
New insights into the in silico prediction of HIV protease resistance to nelfinavir.
PMID:24498124
HIV-1 virologic failure and acquired drug resistance among first-line antiretroviral experienced adults at a rural HIV clinic in coastal Kenya: a cross-sectional study.
PMID:24456757
HIV-1 Protease and Substrate Coevolution Validates the Substrate Envelope As the Substrate Recognition Pattern.
PMID:24348205
Superinfection with drug-resistant HIV is rare and does not contribute substantially to therapy failure in a large European cohort.
PMID:24219163
Selection of RNAi-based inhibitors for anti-HIV gene therapy.
PMID:24175213
Potential elucidation of a novel CTL epitope in HIV-1 protease by the protease inhibitor resistance mutation L90M.
PMID:24015196
The individualized genetic barrier predicts treatment response in a large cohort of HIV-1 infected patients.
PMID:24009493
The prevalence of transmitted resistance to first-generation non-nucleoside reverse transcriptase inhibitors and its potential economic impact in HIV-infected patients.
PMID:23991151
Non-nucleoside reverse transcriptase inhibitor (NNRTI) cross-resistance: implications for preclinical evaluation of novel NNRTIs and clinical genotypic resistance testing.
PMID:23934770
Prototypical Recombinant Multi-Protease-Inhibitor-Resistant Infectious Molecular Clones of Human Immunodeficiency Virus Type 1.
PMID:23796938
Elevated hypermutation levels in HIV-1 natural viral suppressors.
PMID:23791226
SigniSite: Identification of residue-level genotype-phenotype correlations in protein multiple sequence alignments.
PMID:23761454
Selection of drug-resistant feline immunodeficiency virus (FIV) encoding FIV/HIV chimeric protease in the presence of HIV-specific protease inhibitors.
PMID:23720716
Nucleoside reverse transcriptase inhibitor resistance mutations associated with first-line stavudine-containing antiretroviral therapy: programmatic implications for countries phasing out stavudine.
PMID:23687292
In vitro HIV-1 evolution in response to triple reverse transcriptase inhibitors & in silico phenotypic analysis.
PMID:23613794
L74V increases the reverse transcriptase content of HIV-1 virions with non-nucleoside reverse transcriptase drug-resistant mutations L100I+K103N and K101E+G190S, which results in increased fitness.
PMID:23535575
CancerDR: cancer drug resistance database.
PMID:23486013
Transmission patterns of HIV-subtypes A/AE versus B: inferring risk-behavior trends and treatment-efficacy limitations from viral genotypic data obtained prior to and during antiretroviral therapy.
PMID:23469241
Comprehensive in vitro analysis of simian retrovirus type 4 susceptibility to antiretroviral agents.
PMID:23365453
Structural and thermodynamic basis of amprenavir/darunavir and atazanavir resistance in HIV-1 protease with mutations at residue 50.
PMID:23365446
Prevalent polymorphisms in wild-type HIV-1 integrase are unlikely to engender drug resistance to dolutegravir (S/GSK1349572).
PMID:23295935
QColors: an algorithm for conservative viral quasispecies reconstruction from short and non-contiguous next generation sequencing reads.
PMID:23202421
Collinearity of protease mutations in HIV-1 samples with high-level protease inhibitor class resistance.
PMID:23085775
What do molecules do when we are not looking? State sequence analysis for stochastic chemical systems.
PMID:22977098
Correlated electrostatic mutations provide a reservoir of stability in HIV protease.
PMID:22969420
Prediction of mutational tolerance in HIV-1 protease and reverse transcriptase using flexible backbone protein design.
PMID:22927804
Lys66 residue as a determinant of high mismatch extension and misinsertion rates of HIV-1 reverse transcriptase.
PMID:22925131
Cost-effectiveness of tenofovir instead of zidovudine for use in first-line antiretroviral therapy in settings without virological monitoring.
PMID:22905175
Maraviroc observational study: the impact of expanded resistance testing and clinical considerations for antiretroviral regimen selection in treatment-experienced patients.
PMID:22881368
A Perturbation Method for Inference on Regularized Regression Estimates.
PMID:22844171
Global analysis of sequence diversity within HIV-1 subtypes across geographic regions.
PMID:22822410
Minor protease inhibitor mutations at baseline do not increase the risk for a virological failure in HIV-1 subtype B infected patients.
PMID:22719859
Panel of prototypical recombinant infectious molecular clones resistant to nevirapine, efavirenz, etravirine, and rilpivirine.
PMID:22664973
Modeling HIV-1 drug resistance as episodic directional selection.
PMID:22589711
Surveillance of HIV drug resistance in children receiving antiretroviral therapy: a pilot study of the World Health Organization's generic protocol in Maputo, Mozambique.
PMID:22544205
Prevalence of HIV drug resistance before and 1 year after treatment initiation in 4 sites in the Malawi antiretroviral treatment program.
PMID:22544204
HIV-1 phenotypic reverse transcriptase inhibitor drug resistance test interpretation is not dependent on the subtype of the virus backbone.
PMID:22496845
Lopinavir/ritonavir monotherapy after virologic failure of first-line antiretroviral therapy in resource-limited settings.
PMID:22441252
Factors limiting the transmission of HIV mutations conferring drug resistance: fitness costs and genetic bottlenecks.
PMID:22432052
Virologic failures on initial boosted-PI regimen infrequently possess low-level variants with major PI resistance mutations by ultra-deep sequencing.
PMID:22355307
Standardized comparison of the relative impacts of HIV-1 reverse transcriptase (RT) mutations on nucleoside RT inhibitor susceptibility.
PMID:22330916
Genetic diversity of recently acquired and prevalent HIV, hepatitis B virus, and hepatitis C virus infections in US blood donors.
PMID:22293432
The HIVdb system for HIV-1 genotypic resistance interpretation.
PMID:22286876
Endogenous or exogenous spreading of HIV-1 in Nordrhein-Westfalen, Germany, investigated by phylodynamic analysis of the RESINA Study cohort.
PMID:22262052
A multifaceted analysis of HIV-1 protease multidrug resistance phenotypes.
PMID:22172090
Emerging trends of drug-resistant HIV-1 among drug-treated patients in former blood donors in Hubei, China: a three-year surveillance from 2004 to 2006.
PMID:22160938
The impact of molecular manipulation in residue 114 of human immunodeficiency virus type-1 reverse transcriptase on dNTP substrate binding and viral replication.
PMID:22153297
The evolution of HIV: inferences using phylogenetics.
PMID:22138161
Directed HIV-1 evolution of protease inhibitor resistance by second-generation short hairpin RNAs.
PMID:22064528
Reverse transcriptase drug resistance mutations in HIV-1 subtype C infected patients on ART in Karonga District, Malawi.
PMID:21995490
Drug resistance mutations in HIV pol sequences from Argentinean patients under antiretroviral treatment: subtype, gender, and age issues.
PMID:21936717
Sequence quality analysis tool for HIV type 1 protease and reverse transcriptase.
PMID:21916749
Biochemical, inhibition and inhibitor resistance studies of xenotropic murine leukemia virus-related virus reverse transcriptase.
PMID:21908397
STRUCTURED, SPARSE REGRESSION WITH APPLICATION TO HIV DRUG RESISTANCE.
PMID:21892380
Efficient identification of human immunodeficiency virus type 1 mutants resistant to a protease inhibitor by using a random mutant library.
PMID:21876045
The higher barrier of darunavir and tipranavir resistance for HIV-1 protease.
PMID:21871444
Cell-to-cell spread of HIV permits ongoing replication despite antiretroviral therapy.
PMID:21849975
Nonnucleoside reverse transcriptase inhibitor-resistant HIV is stimulated by efavirenz during early stages of infection.
PMID:21835788
Missing data on the estimation of the prevalence of accumulated human immunodeficiency virus drug resistance in patients treated with antiretroviral drugs in north america.
PMID:21813792
Accessory mutations maintain stability in drug-resistant HIV-1 protease.
PMID:21762813
Dynamics of preferential substrate recognition in HIV-1 protease: redefining the substrate envelope.
PMID:21762811
Randomized trial of time-limited interruptions of protease inhibitor-based antiretroviral therapy (ART) vs. continuous therapy for HIV-1 infection.
PMID:21738668
HIVToolbox, an integrated web application for investigating HIV.
PMID:21647445
Genetic draft and quasi-neutrality in large facultatively sexual populations.
PMID:21625002
Role of induced fit in limiting discrimination against AZT by HIV reverse transcriptase.
PMID:21548586
Identification of new, emerging HIV-1 unique recombinant forms and drug resistant viruses circulating in Cameroon.
PMID:21513545
Dose-response curve slope is a missing dimension in the analysis of HIV-1 drug resistance.
PMID:21502494
HIV-1 integrase inhibitor resistance and its clinical implications.
PMID:21459813
Intensity of deoxycytidine deamination of HIV-1 proviral DNA by the retroviral restriction factor APOBEC3G is mediated by the noncatalytic domain.
PMID:21300806
Performance of the Abbott RealTime HIV-1 viral load assay is not impacted by integrase inhibitor resistance-associated mutations.
PMID:21289145
Human immunodeficiency virus type 1 resistance or cross-resistance to nonnucleoside reverse transcriptase inhibitors currently under development as microbicides.
PMID:21282453
Proteochemometric modeling of the susceptibility of mutated variants of the HIV-1 virus to reverse transcriptase inhibitors.
PMID:21179544
Early virologic failure and the development of antiretroviral drug resistance mutations in HIV-infected Ugandan children.
PMID:21099693
Cohort profile: The PharmAccess African (PASER-M) and the TREAT Asia (TASER-M) monitoring studies to evaluate resistance--HIV drug resistance in sub-Saharan Africa and the Asia-Pacific.
PMID:21071386
Call for a quality standard for sequence-based assays in clinical microbiology: necessity for quality assessment of sequences used in microbial identification and typing.
PMID:21068275
Drug resistance mutations in drug-naive HIV type 1 subtype C-infected individuals from rural Malawi.
PMID:20950147
Constraints on HIV-1 diversity from protein structure.
PMID:20881050
Higher levels of Zidovudine resistant HIV in the colon compared to blood and other gastrointestinal compartments in HIV infection.
PMID:20836880
HIV-1 protease mutations and protease inhibitor cross-resistance.
PMID:20660676
Cellular HIV-1 DNA levels in drug sensitive strains are equivalent to those in drug resistant strains in newly-diagnosed patients in Europe.
PMID:20544014
Nucleic acid template and the risk of a PCR-Induced HIV-1 drug resistance mutation.
PMID:20539818
Prevalence and clinical significance of HIV drug resistance mutations by ultra-deep sequencing in antiretroviral-naïve subjects in the CASTLE study.
PMID:20532178
Constrained patterns of covariation and clustering of HIV-1 non-nucleoside reverse transcriptase inhibitor resistance mutations.
PMID:20462946
Predicting tipranavir and darunavir resistance using genotypic, phenotypic, and virtual phenotypic resistance patterns: an independent cohort analysis of clinical isolates highly resistant to all other protease inhibitors.
PMID:20368406
Combinations of mutations in the connection domain of human immunodeficiency virus type 1 reverse transcriptase: assessing the impact on nucleoside and nonnucleoside reverse transcriptase inhibitor resistance.
PMID:20194692
Only slight impact of predicted replicative capacity for therapy response prediction.
PMID:20140263
The mutation T477A in HIV-1 reverse transcriptase (RT) restores normal proteolytic processing of RT in virus with Gag-Pol mutated in the p51-RNH cleavage site.
PMID:20122159
Detecting and understanding combinatorial mutation patterns responsible for HIV drug resistance.
PMID:20080674
HIV-1 reverse transcriptase drug-resistance mutations in chronically infected individuals receiving or naïve to HAART in Cameroon.
PMID:20029816
Non-nucleoside reverse transcriptase inhibitor outcomes among combination antiretroviral therapy-treated adults in Botswana.
PMID:20023437
Identification of structural mechanisms of HIV-1 protease specificity using computational peptide docking: implications for drug resistance.
PMID:20004167
Pairwise and higher-order correlations among drug-resistance mutations in HIV-1 subtype B protease.
PMID:19758465
Nonpolymorphic human immunodeficiency virus type 1 protease and reverse transcriptase treatment-selected mutations.
PMID:19721070
Human immunodeficiency virus type 1 protease-correlated cleavage site mutations enhance inhibitor resistance.
PMID:19706699
Transmitted antiretroviral drug resistance among acute and recent HIV infections in North Carolina from 1998 to 2007.
PMID:19704170
Host sequence motifs shared by HIV predict response to antiretroviral therapy.
PMID:19627600
Are all subtypes created equal? The effectiveness of antiretroviral therapy against non-subtype B HIV-1.
PMID:19331584
The calibrated population resistance tool: standardized genotypic estimation of transmitted HIV-1 drug resistance.
PMID:19304876
Prevalence of drug-resistant HIV-1 in rural areas of Hubei province in the People's Republic of China.
PMID:19295329
The folding free-energy surface of HIV-1 protease: insights into the thermodynamic basis for resistance to inhibitors.
PMID:19150359
Distinct resistance mutation and polymorphism acquisition in HIV-1 protease of subtypes B and F1 from children and adult patients under virological failure.
PMID:18992847
Rtreemix: an R package for estimating evolutionary pathways and genetic progression scores.
PMID:18718947
Minority human immunodeficiency virus type 1 variants in antiretroviral-naive persons with reverse transcriptase codon 215 revertant mutations.
PMID:18715933
Predicting drug resistance of the HIV-1 protease using molecular interaction energy components.
PMID:18704937
An ontology-driven method for hierarchical mining of temporal patterns: application to HIV drug resistance research.
PMID:18693909
HIV-1 drug resistance mutations: an updated framework for the second decade of HAART.
PMID:18615118
Selecting anti-HIV therapies based on a variety of genomic and clinical factors.
PMID:18586740
Consensus drug resistance mutations for epidemiological surveillance: basic principles and potential controversies.
PMID:18575192
Genotypic susceptibility scores and HIV type 1 RNA responses in treatment-experienced subjects with HIV type 1 infection.
PMID:18462083
Viral population estimation using pyrosequencing.
PMID:18437230
Comparison of algorithms that interpret genotypic HIV-1 drug resistance to determine the prevalence of transmitted drug resistance.
PMID:18427201
Proteochemometric modeling of HIV protease susceptibility.
PMID:18402661
Analysis of correlated mutations in HIV-1 protease using spectral clustering.
PMID:18375964
Stability analysis of mixtures of mutagenetic trees.
PMID:18366778
Sequence editing by Apolipoprotein B RNA-editing catalytic component [corrected] and epidemiological surveillance of transmitted HIV-1 drug resistance.
PMID:18356601
Conservation patterns of HIV-1 RT connection and RNase H domains: identification of new mutations in NRTI-treated patients.
PMID:18335052
Molecular mechanisms of FIV infection.
PMID:18289701
An evolutionary-network model reveals stratified interactions in the V3 loop of the HIV-1 envelope.
PMID:18039027
Prevalence of darunavir resistance-associated mutations: patterns of occurrence and association with past treatment.
PMID:17955436
Mapping protease inhibitor resistance to human immunodeficiency virus type 1 sequence polymorphisms within patients.
PMID:17913806
Distinguishing functional amino acid covariation from background linkage disequilibrium in HIV protease and reverse transcriptase.
PMID:17726544
Differential drug resistance acquisition in HIV-1 of subtypes B and C.
PMID:17710130
DNA bar coding and pyrosequencing to identify rare HIV drug resistance mutations.
PMID:17576693
X-ray crystal structures of human immunodeficiency virus type 1 protease mutants complexed with atazanavir.
PMID:17537865
Selection of mutations in the connection and RNase H domains of human immunodeficiency virus type 1 reverse transcriptase that increase resistance to 3'-azido-3'-dideoxythymidine.
PMID:17507476
HIV-1 subtype B protease and reverse transcriptase amino acid covariation.
PMID:17500586
Both human immunodeficiency virus cellular DNA sequencing and plasma RNA sequencing are useful for detection of drug resistance mutations in blood samples from antiretroviral-drug-naive patients.
PMID:17442799
Adaptation to human populations is revealed by within-host polymorphisms in HIV-1 and hepatitis C virus.
PMID:17397261
Ontology-driven mapping of temporal data in biomedical databases.
PMID:17238664
Prediction of HIV mutation changes based on treatment history.
PMID:17238630
N88D facilitates the co-occurrence of D30N and L90M and the development of multidrug resistance in HIV type 1 protease following nelfinavir treatment failure.
PMID:17209774
HIV-1 protease and reverse transcriptase mutations for drug resistance surveillance.
PMID:17197813
The HIV positive selection mutation database.
PMID:17108357
Genotypic predictors of human immunodeficiency virus type 1 drug resistance.
PMID:17065321
In vitro human immunodeficiency virus type 1 resistance selections with combinations of tenofovir and emtricitabine or abacavir and lamivudine.
PMID:16982781
Rationale and uses of a public HIV drug-resistance database.
PMID:16921473
Use of the l1 norm for selection of sparse parameter sets that accurately predict drug response phenotype from viral genetic sequences.
PMID:16779091
Web resources for HIV type 1 genotypic-resistance test interpretation.
PMID:16652319
DR_SEQAN: a PC/Windows-based software to evaluate drug resistance using human immunodeficiency virus type 1 genotypes.
PMID:16524459
Inhibitory effects of archetypical nucleic acid ligands on the interactions of HIV-1 nucleocapsid protein with elements of Psi-RNA.
PMID:16522643
SVARAP and aSVARAP: simple tools for quantitative analysis of nucleotide and amino acid variability and primer selection for clinical microbiology.
PMID:16515699
HIV-1 pol mutation frequency by subtype and treatment experience: extension of the HIVseq program to seven non-B subtypes.
PMID:16514293
Effectiveness of nonpeptide clinical inhibitor TMC-114 on HIV-1 protease with highly drug resistant mutations D30N, I50V, and L90M.
PMID:16480273
HIV-1 Protease and reverse-transcriptase mutations: correlations with antiretroviral therapy in subtype B isolates and implications for drug-resistance surveillance.
PMID:15995959
Insertions in the human immunodeficiency virus type 1 protease and reverse transcriptase genes: clinical impact and molecular mechanisms.
PMID:15980322
Physicochemical constraint violation by missense substitutions mediates impairment of protein function and disease severity.
PMID:15965030
Drug resistance and antiretroviral drug development.
PMID:15845781
Impact of HIV-1 subtype and antiretroviral therapy on protease and reverse transcriptase genotype: results of a global collaboration.
PMID:15839752
Comparison of the precision and sensitivity of the Antivirogram and PhenoSense HIV drug susceptibility assays.
PMID:15764961
Immunologic pressure within class I-restricted cognate human immunodeficiency virus epitopes during highly active antiretroviral therapy.
PMID:15731259
Molecular dynamics simulations of 14 HIV protease mutants in complexes with indinavir.
PMID:15597206
Association of a novel human immunodeficiency virus type 1 protease substrate cleft mutation, L23I, with protease inhibitor therapy and in vitro drug resistance.
PMID:15561868
Nucleotide specificity of HIV-1 reverse transcriptases with amino acid substitutions affecting Ala-114.
PMID:15548134
Distribution of human immunodeficiency virus type 1 protease and reverse transcriptase mutation patterns in 4,183 persons undergoing genotypic resistance testing.
PMID:15273130
Evolution of resistance to drugs in HIV-1-infected patients failing antiretroviral therapy.
PMID:15238768
Mutation D30N is not preferentially selected by human immunodeficiency virus type 1 subtype C in the development of resistance to nelfinavir.
PMID:15155216
Characterization of a subtype D human immunodeficiency virus type 1 isolate that was obtained from an untreated individual and that is highly resistant to nonnucleoside reverse transcriptase inhibitors.
PMID:15113918
HIV-1 protease molecular dynamics of a wild-type and of the V82F/I84V mutant: possible contributions to drug resistance and a potential new target site for drugs.
PMID:15044738
Positive selection detection in 40,000 human immunodeficiency virus (HIV) type 1 sequences automatically identifies drug resistance and positive fitness mutations in HIV protease and reverse transcriptase.
PMID:15016892
Increased G-->A transition frequencies displayed by primer grip mutants of human immunodeficiency virus type 1 reverse transcriptase.
PMID:14694133
Geno2pheno: Estimating phenotypic drug resistance from HIV-1 genotypes.
PMID:12824435