ReplicationDomain (alias ChromosomeDomain)

Eukaryotic DNA replication is regulated at the level of large chromosomal domains (0.5–5 megabases in mammals). These replication domains replicate in a stable, cell type-specific temporal order during S-phase that is closely linked to their 3 dimensional organization in the nucleus and the expression of genes within each replication domain (Hiratani et al., Genome Res, 2010). ReplicationDomain is a database customized for analysis of genome-wide replication timing maps (replication profiles) from various cell lines and species and comparison to other genome-wide properties of chromosomes, such as transcription and chromatin immunoprecipitation data, which can also be uploaded and viewed (Weddington et al., BMC Bioinformatics, 2008). Users may graphically display these data sets for a selected genomic region and download the data displayed as text files, or alternatively, download complete genome-wide data sets. ReplicationDomain is considerably faster and more convenient than existing browsers when viewing multi-megabase segments of chromosomes. Furthermore, we have implemented a user registration system that allows registered users to upload their own data sets. Upon uploading, registered users may choose to: (1) view their data sets privately without sharing; (2) share their data sets with any subset of the sites registered users; or (3) make their published or “in pressâ€Â\x9D data sets publicly available.

Webpage:
http://www.replicationdomain.org/andhttp://www.chromosomedomain.org/

Publications:

Tags:

molecular biology

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