Phenomics of yeast Mutants
Names
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Phenomics of yeast Mutants
metasource: Fairsharing.org
version: FAIRsharing.org: PhenoM; Phenomics of yeast Mutants; DOI: https://doi.org/10.25504/FAIRsharing.bp5hpt; Last edited: Jan. 8, 2019, 1:14 p.m.; Last accessed: Jan 03 2022 7:07 p.m.
metasource: re3data.org
version: re3data.org: PhenoM; editing status 2021-08-25; re3data.org - Registry of Research Data Repositories. http://doi.org/10.17616/R3GJ5J last accessed: 2022-11-04
PhenoM
metasource: Fairsharing.org
version: FAIRsharing.org: PhenoM; Phenomics of yeast Mutants; DOI: https://doi.org/10.25504/FAIRsharing.bp5hpt; Last edited: Jan. 8, 2019, 1:14 p.m.; Last accessed: Jan 03 2022 7:07 p.m.
metasource: Nucleic Acid Research database catalogue
version: extracted_at: 2022-11-04T11:16:25.468657
metasource: re3data.org
version: re3data.org: PhenoM; editing status 2021-08-25; re3data.org - Registry of Research Data Repositories. http://doi.org/10.17616/R3GJ5J last accessed: 2022-11-04
metasource: bio.tools
version: extracted_at: 2022-11-04T11:34:18.067086
phenom
metasource: bio.tools
version: extracted_at: 2022-11-04T11:34:18.067086
Names
More detailed information about this field from each metasource.
Phenomics of yeast Mutants
metasource: Fairsharing.orgversion: FAIRsharing.org: PhenoM; Phenomics of yeast Mutants; DOI: https://doi.org/10.25504/FAIRsharing.bp5hpt; Last edited: Jan. 8, 2019, 1:14 p.m.; Last accessed: Jan 03 2022 7:07 p.m.
metasource: re3data.org
version: re3data.org: PhenoM; editing status 2021-08-25; re3data.org - Registry of Research Data Repositories. http://doi.org/10.17616/R3GJ5J last accessed: 2022-11-04
PhenoM
metasource: Fairsharing.orgversion: FAIRsharing.org: PhenoM; Phenomics of yeast Mutants; DOI: https://doi.org/10.25504/FAIRsharing.bp5hpt; Last edited: Jan. 8, 2019, 1:14 p.m.; Last accessed: Jan 03 2022 7:07 p.m.
metasource: Nucleic Acid Research database catalogue
version: extracted_at: 2022-11-04T11:16:25.468657
metasource: re3data.org
version: re3data.org: PhenoM; editing status 2021-08-25; re3data.org - Registry of Research Data Repositories. http://doi.org/10.17616/R3GJ5J last accessed: 2022-11-04
metasource: bio.tools
version: extracted_at: 2022-11-04T11:34:18.067086
phenom
metasource: bio.toolsversion: extracted_at: 2022-11-04T11:34:18.067086
Names
More detailed information about this field from each metasource.
Phenomics of yeast Mutants
metasource: Fairsharing.orgversion: FAIRsharing.org: PhenoM; Phenomics of yeast Mutants; DOI: https://doi.org/10.25504/FAIRsharing.bp5hpt; Last edited: Jan. 8, 2019, 1:14 p.m.; Last accessed: Jan 03 2022 7:07 p.m.
metasource: re3data.org
version: re3data.org: PhenoM; editing status 2021-08-25; re3data.org - Registry of Research Data Repositories. http://doi.org/10.17616/R3GJ5J last accessed: 2022-11-04
PhenoM
metasource: Fairsharing.orgversion: FAIRsharing.org: PhenoM; Phenomics of yeast Mutants; DOI: https://doi.org/10.25504/FAIRsharing.bp5hpt; Last edited: Jan. 8, 2019, 1:14 p.m.; Last accessed: Jan 03 2022 7:07 p.m.
metasource: Nucleic Acid Research database catalogue
version: extracted_at: 2022-11-04T11:16:25.468657
metasource: re3data.org
version: re3data.org: PhenoM; editing status 2021-08-25; re3data.org - Registry of Research Data Repositories. http://doi.org/10.17616/R3GJ5J last accessed: 2022-11-04
metasource: bio.tools
version: extracted_at: 2022-11-04T11:34:18.067086
phenom
metasource: bio.toolsversion: extracted_at: 2022-11-04T11:34:18.067086
PhenoM (Phenomics of yeast Mutants) stores, retrieves, visualises and data mines the quantitative single-cell measurements extracted from micrographs of temperature-sensitive mutant cells. PhenoM allows users to rapidly search and retrieve raw images and their quantified morphological data for genes of interest. The database also provides several data-mining tools, including a PhenoBlast module for phenotypic comparison between mutant strains and a Gene Ontology module for functional enrichment analysis of gene sets showing similar morphological alterations.
Description
More detailed information about this field from each metasource.
PhenoM (Phenomics of yeast Mutants) stores, retrieves, visualises and data mines the quantitative single-cell measurements extracted from micrographs of temperature-sensitive mutant cells. PhenoM allows users to rapidly search and retrieve raw images and their quantified morphological data for genes of interest. The database also provides several data-mining tools, including a PhenoBlast module for phenotypic comparison between mutant strains and a Gene Ontology module for functional enrichment analysis of gene sets showing similar morphological alterations.
metasource: Fairsharing.orgversion: FAIRsharing.org: PhenoM; Phenomics of yeast Mutants; DOI: https://doi.org/10.25504/FAIRsharing.bp5hpt; Last edited: Jan. 8, 2019, 1:14 p.m.; Last accessed: Jan 03 2022 7:07 p.m.
Morphological database of essential yeast genes
metasource: Nucleic Acid Research database catalogueversion: extracted_at: 2022-11-04T11:16:25.468657
PhenoM (Phenomics of yeast Mutants) stores, retrieves, visualises and data mines the quantitative single-cell measurements extracted from micrographs of temperature-sensitive mutant cells.
metasource: re3data.orgversion: re3data.org: PhenoM; editing status 2021-08-25; re3data.org - Registry of Research Data Repositories. http://doi.org/10.17616/R3GJ5J last accessed: 2022-11-04
Phenomics of yeast Mutants (PhenoM): contains quantitative measurements of 1,909,914 cells and 78,194 morphological images for 775 temperature-sensitive mutants spanning 491 different essential genes in permissive temperature (26 C) and restrictive temperature (32 C).
metasource: bio.toolsversion: extracted_at: 2022-11-04T11:34:18.067086
Webpage:
http://phenom.ccbr.utoronto.ca/Webpage
More detailed information about this field from each metasource.
http://phenom.ccbr.utoronto.ca/
metasource: Fairsharing.orgversion: FAIRsharing.org: PhenoM; Phenomics of yeast Mutants; DOI: https://doi.org/10.25504/FAIRsharing.bp5hpt; Last edited: Jan. 8, 2019, 1:14 p.m.; Last accessed: Jan 03 2022 7:07 p.m.
metasource: re3data.org
version: re3data.org: PhenoM; editing status 2021-08-25; re3data.org - Registry of Research Data Repositories. http://doi.org/10.17616/R3GJ5J last accessed: 2022-11-04
metasource: bio.tools
version: extracted_at: 2022-11-04T11:34:18.067086
http://phenom.ccbr.utoronto.ca
metasource: Nucleic Acid Research database catalogueversion: extracted_at: 2022-11-04T11:16:25.468657
Licence:
Name: Public DomainLicence name
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Public Domain
metasource: re3data.orgversion: re3data.org: PhenoM; editing status 2021-08-25; re3data.org - Registry of Research Data Repositories. http://doi.org/10.17616/R3GJ5J last accessed: 2022-11-04
Licence URL
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http://phenom.ccbr.utoronto.ca/index.jsp
metasource: re3data.orgversion: re3data.org: PhenoM; editing status 2021-08-25; re3data.org - Registry of Research Data Repositories. http://doi.org/10.17616/R3GJ5J last accessed: 2022-11-04
Publications:
Publications
More detailed information about this field from each metasource.
Systematic exploration of essential yeast gene function with temperature-sensitive mutants
PMID: 21441928
metasource: Fairsharing.org
version: FAIRsharing.org: PhenoM; Phenomics of yeast Mutants; DOI: https://doi.org/10.25504/FAIRsharing.bp5hpt; Last edited: Jan. 8, 2019, 1:14 p.m.; Last accessed: Jan 03 2022 7:07 p.m.
PhenoM: a database of morphological phenotypes caused by mutation of essential genes in Saccharomyces cerevisiae
PMID: 22009677
metasource: Fairsharing.org
version: FAIRsharing.org: PhenoM; Phenomics of yeast Mutants; DOI: https://doi.org/10.25504/FAIRsharing.bp5hpt; Last edited: Jan. 8, 2019, 1:14 p.m.; Last accessed: Jan 03 2022 7:07 p.m.
metasource: bio.tools
version: extracted_at: 2022-11-04T11:34:18.067086
http://dx.doi.org/10.1093/nar/GKR827
metasource: Nucleic Acid Research database catalogue
version: extracted_at: 2022-11-04T11:16:25.468657
Publications
More detailed information about this field from each metasource.
Systematic exploration of essential yeast gene function with temperature-sensitive mutants
PMID: 21441928
metasource: Fairsharing.org
version: FAIRsharing.org: PhenoM; Phenomics of yeast Mutants; DOI: https://doi.org/10.25504/FAIRsharing.bp5hpt; Last edited: Jan. 8, 2019, 1:14 p.m.; Last accessed: Jan 03 2022 7:07 p.m.
PhenoM: a database of morphological phenotypes caused by mutation of essential genes in Saccharomyces cerevisiae
PMID: 22009677
metasource: Fairsharing.org
version: FAIRsharing.org: PhenoM; Phenomics of yeast Mutants; DOI: https://doi.org/10.25504/FAIRsharing.bp5hpt; Last edited: Jan. 8, 2019, 1:14 p.m.; Last accessed: Jan 03 2022 7:07 p.m.
metasource: bio.tools
version: extracted_at: 2022-11-04T11:34:18.067086
http://dx.doi.org/10.1093/nar/GKR827
metasource: Nucleic Acid Research database catalogueversion: extracted_at: 2022-11-04T11:16:25.468657
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Systematic exploration of essential yeast gene function with temperature-sensitive mutants
PubMed citations: 203.
203 articles citing: Systematic exploration of essential yeast gene function with temperature-sensitive mutants
A Special Phenotype of Aconidial Aspergillus niger SH2 and Its Mechanism of Formation via CRISPRi. PMID:35887436
The centromeric histone CenH3 is recruited into the tombusvirus replication organelles. PMID:35767596
Lsm7 phase-separated condensates trigger stress granule formation. PMID:35764627
Evidence that conserved essential genes are enriched for pro-longevity factors. PMID:35695982
Humanized yeast to model human biology, disease and evolution. PMID:35661208
Race against Time between the Virus and Host: Actin-Assisted Rapid Biogenesis of Replication Organelles is Used by TBSV to Limit the Recruitment of Cellular Restriction Factors. PMID:35638821
Genetic background and mistranslation frequency determine the impact of mistranslating tRNASerUGG. PMID:35587152
The structure balance of gene-gene networks beyond pairwise interactions. PMID:35353818
Phenomics approaches to understand genetic networks and gene function in yeast. PMID:35285506
From Petri Plates to Petri Nets, a revolution in yeast biology. PMID:35142857
High-throughput replica-pinning approach to screen for yeast genes controlling low-frequency events. PMID:35059655
Reconstruction of human genome evolution in yeast: an educational primer for use with "systematic humanization of the yeast cytoskeleton discerns functionally replaceable from divergent human genes". PMID:34849890
Systematic High-Content Screening of Fluorescently Tagged Yeast Double Mutant Strains. PMID:34590270
Mapping Synthetic Dosage Lethal Genetic Interactions in Saccharomyces cerevisiae. PMID:34590269
The amino acid substitution affects cellular response to mistranslation. PMID:34568909
A synthetic lethal screen identifies HDAC4 as a potential target in MELK overexpressing cancers. PMID:34550356
Identification of essential genes in Caenorhabditis elegans through whole-genome sequencing of legacy mutant collections. PMID:34550348
Chemical rescue of mutant proteins in living Saccharomyces cerevisiae cells by naturally occurring small molecules. PMID:34544143
A CRISPR Interference Screen of Essential Genes Reveals that Proteasome Regulation Dictates Acetic Acid Tolerance in Saccharomyces cerevisiae. PMID:34313457
A nuclear proteome localization screen reveals the exquisite specificity of Gpn2 in RNA polymerase biogenesis. PMID:34180355
A novel viral strategy for host factor recruitment: The co-opted proteasomal Rpn11 protein interaction hub in cooperation with subverted actin filaments are targeted to deliver cytosolic host factors for viral replication. PMID:34161398
Single-cell image analysis to explore cell-to-cell heterogeneity in isogenic populations. PMID:34139168
A genome-scale yeast library with inducible expression of individual genes. PMID:34096681
High-Throughput Imaging of Arrays of Fluorescently Tagged Yeast Mutant Strains. PMID:34028720
Timer-based proteomic profiling of the ubiquitin-proteasome system reveals a substrate receptor of the GID ubiquitin ligase. PMID:33974913
Environmental robustness of the global yeast genetic interaction network. PMID:33958448
Trigenic Synthetic Genetic Array (τ-SGA) Technique for Complex Interaction Analysis. PMID:33733368
Eukaryotic translation factor eIF5A contributes to acetic acid tolerance in Saccharomyces cerevisiae via transcriptional factor Ume6p. PMID:33557922
In-depth and 3-dimensional exploration of the budding yeast phosphoproteome. PMID:33491328
τ-SGA: synthetic genetic array analysis for systematically screening and quantifying trigenic interactions in yeast. PMID:33462440
Temperature Sensitive Photosynthesis: Point Mutated CEF-G, PRK, or PsbO Act as Temperature-Controlled Switches for Essential Photosynthetic Processes. PMID:33101332
Chemical-Genetic Interactions with the Proline Analog L-Azetidine-2-Carboxylic Acid in Saccharomyces cerevisiae. PMID:33082270
Statistical mechanics of chromosomes: in vivo and in silico approaches reveal high-level organization and structure arise exclusively through mechanical feedback between loop extruders and chromatin substrate properties. PMID:33080019
A novel assay provides insight into tRNAPhe retrograde nuclear import and re-export in S. cerevisiae. PMID:33074312
TheCellVision.org: A Database for Visualizing and Mining High-Content Cell Imaging Projects. PMID:32934016
Asymmetric Transcription Factor Partitioning During Yeast Cell Division Requires the FACT Chromatin Remodeler and Cell Cycle Progression. PMID:32878900
Advances in fungal chemical genomics for the discovery of new antifungal agents. PMID:32860238
Polo kinase recruitment via the constitutive centromere-associated network at the kinetochore elevates centromeric RNA. PMID:32810142
Exploring whole-genome duplicate gene retention with complex genetic interaction analysis. PMID:32586993
A septin-Hof1 scaffold at the yeast bud neck binds and organizes actin cables. PMID:32579428
Systematic Humanization of the Yeast Cytoskeleton Discerns Functionally Replaceable from Divergent Human Genes. PMID:32522745
Chaperone-Mediated Protein Disaggregation Triggers Proteolytic Clearance of Intra-nuclear Protein Inclusions. PMID:32492414
Humanization of yeast genes with multiple human orthologs reveals functional divergence between paralogs. PMID:32421706
High-throughput enrichment of temperature-sensitive argininosuccinate synthetase for two-stage citrulline production in E. coli. PMID:32179161
mSphere of Influence: Comprehensive Genetic Analysis. PMID:32161149
CATS: Cas9-assisted tag switching. A high-throughput method for exchanging genomic peptide tags in yeast. PMID:32156257
A protein quality control pathway at the mitochondrial outer membrane. PMID:32118579
Systematic genetics and single-cell imaging reveal widespread morphological pleiotropy and cell-to-cell variability. PMID:32064787
Skp, Cullin, F-box (SCF)-Met30 and SCF-Cdc4-Mediated Proteolysis of CENP-A Prevents Mislocalization of CENP-A for Chromosomal Stability in Budding Yeast. PMID:32032354
Spatial Organization of Proteasome Aggregates in the Regulation of Proteasome Homeostasis. PMID:31998748
Dual role of a GTPase conformational switch for membrane fusion by mitofusin ubiquitylation. PMID:31857350
Quality Control of Protein Complex Assembly by a Transmembrane Recognition Factor. PMID:31679820
Genetic Screens to Study GAA/TTC and Inverted Repeat Instability in Saccharomyces cerevisiae. PMID:31586343
The Mutator Phenotype: Adapting Microbial Evolution to Cancer Biology. PMID:31447882
Identification of Yeast Factors Involved in the Replication of Mungbean Yellow Mosaic India Virus Using Yeast Temperature-Sensitive Mutants. PMID:31429012
Pol5 is an essential ribosome biogenesis factor required for 60S ribosomal subunit maturation in Saccharomyces cerevisiae. PMID:31413149
Essential Saccharomyces cerevisiae genome instability suppressing genes identify potential human tumor suppressors. PMID:31409704
Endosome and Golgi-associated degradation (EGAD) of membrane proteins regulates sphingolipid metabolism. PMID:31368600
Rad5 dysregulation drives hyperactive recombination at replication forks resulting in cisplatin sensitivity and genome instability. PMID:31350889
Cooperation of mitochondrial and ER factors in quality control of tail-anchored proteins. PMID:31172943
Integrating yeast chemical genomics and mammalian cell pathway analysis. PMID:31138898
Exocyst Subcomplex Functions in Autophagosome Biogenesis by Regulating Atg9 Trafficking. PMID:31103773
Exonuclease domain mutants of yeast DIS3 display genome instability. PMID:30724665
Auxin-Inducible Depletion of the Essentialome Suggests Inhibition of TORC1 by Auxins and Inhibition of Vrg4 by SDZ 90-215, a Natural Antifungal Cyclopeptide. PMID:30670608
Chemical-Chemical Combinations Map Uncharted Interactions in Escherichia coli under Nutrient Stress. PMID:30428373
Unbiased Fitness Estimation of Pooled Barcode or Amplicon Sequencing Studies. PMID:30391162
Nuclear envelope expansion in budding yeast is independent of cell growth and does not determine nuclear volume. PMID:30379612
Heat-stress triggers MAPK crosstalk to turn on the hyperosmotic response pathway. PMID:30310096
Yeast genetic interaction screens in the age of CRISPR/Cas. PMID:30255296
Reconstitution reveals Ykt6 as the autophagosomal SNARE in autophagosome-vacuole fusion. PMID:30097514
Functions of the COPII gene paralogs SEC23A and SEC23B are interchangeable in vivo. PMID:30065114
A Genome-Wide Screen Reveals a Role for the HIR Histone Chaperone Complex in Preventing Mislocalization of Budding Yeast CENP-A. PMID:30012561
The Inner Nuclear Membrane Is a Metabolically Active Territory that Generates Nuclear Lipid Droplets. PMID:29937227
Determinants of the cytosolic turnover of mitochondrial intermembrane space proteins. PMID:29929515
Precise, automated control of conditions for high-throughput growth of yeast and bacteria with eVOLVER. PMID:29889214
Quantitative imaging of chromatin decompaction in living cells. PMID:29771637
High-dimensional single-cell phenotyping reveals extensive haploinsufficiency. PMID:29768403
Multiple chemo-genetic interactions between a toxic metabolite and the ubiquitin pathway in yeast. PMID:29721631
Systematic analysis of complex genetic interactions. PMID:29674565
H3K4 Methylation Dependent and Independent Chromatin Regulation by JHD2 and SET1 in Budding Yeast. PMID:29599176
Database for High Throughput Screening Hits (dHITS): a simple tool to retrieve gene specific phenotypes from systematic screens done in yeast. PMID:29574976
Translocon Declogger Ste24 Protects against IAPP Oligomer-Induced Proteotoxicity. PMID:29526462
The yeast Ty1 retrotransposon requires components of the nuclear pore complex for transcription and genomic integration. PMID:29514267
Global study of holistic morphological effectors in the budding yeast Saccharomyces cerevisiae. PMID:29458326
Organelle luminal dependence of (+)strand RNA virus replication reveals a hidden druggable target. PMID:29387794
Whole-Genome Sequencing of Suppressor DNA Mixtures Identifies Pathways That Compensate for Chromosome Segregation Defects in Schizosaccharomyces pombe. PMID:29352077
Cdc48 regulates a deubiquitylase cascade critical for mitochondrial fusion. PMID:29309037
Compensatory Internalization of Pma1 in V-ATPase Mutants in Saccharomyces cerevisiae Requires Calcium- and Glucose-Sensitive Phosphatases. PMID:29254995
CRISPR-UnLOCK: Multipurpose Cas9-Based Strategies for Conversion of Yeast Libraries and Strains. PMID:28979241
DNA replication stress restricts ribosomal DNA copy number. PMID:28915237
Genome-scale modeling of yeast: chronology, applications and critical perspectives. PMID:28899034
Evolutionary conserved role of eukaryotic translation factor eIF5A in the regulation of actin-nucleating formins. PMID:28852021
Taxonomically Restricted Genes with Essential Functions Frequently Play Roles in Chromosome Segregation in Caenorhabditis elegans and Saccharomyces cerevisiae. PMID:28839119
Genome-Scale Genetic Interactions and Cell Imaging Confirm Cytokinesis as Deleterious to Transient Topoisomerase II Deficiency in Saccharomyces cerevisiae. PMID:28839115
Direct interaction of the Golgi V-ATPase a-subunit isoform with PI(4)P drives localization of Golgi V-ATPases in yeast. PMID:28720663
Systematic bacterialization of yeast genes identifies a near-universally swappable pathway. PMID:28661399
Characterization of spindle pole body duplication reveals a regulatory role for nuclear pore complexes. PMID:28659328
Systematic analysis of Ca2+ homeostasis in Saccharomyces cerevisiae based on chemical-genetic interaction profiles. PMID:28566553
eIF5A facilitates translation termination globally and promotes the elongation of many non polyproline-specific tripeptide sequences. PMID:28549188
Identifying pathogenicity of human variants via paralog-based yeast complementation. PMID:28542158
Parallel reorganization of protein function in the spindle checkpoint pathway through evolutionary paths in the fitness landscape that appear neutral in laboratory experiments. PMID:28410373
Regulation of DNA Replication through Natural Impediments in the Eukaryotic Genome. PMID:28272375
A method for high-throughput production of sequence-verified DNA libraries and strain collections. PMID:28193641
Functional Analysis of Kinases and Transcription Factors in Saccharomyces cerevisiae Using an Integrated Overexpression Library. PMID:28122947
High-Throughput Robotically Assisted Isolation of Temperature-sensitive Lethal Mutants in Chlamydomonas reinhardtii. PMID:28060315
A genome wide dosage suppressor network reveals genomic robustness. PMID:27899637
Maintaining protein homeostasis: early and late endosomal dual recycling for the maintenance of intracellular pools of the plasma membrane protein Chs3. PMID:27798229
A global genetic interaction network maps a wiring diagram of cellular function. PMID:27708008
Exploring Quantitative Yeast Phenomics with Single-Cell Analysis of DNA Damage Foci. PMID:27617677
A Synthetic Dosage Lethal Genetic Interaction Between CKS1B and PLK1 Is Conserved in Yeast and Human Cancer Cells. PMID:27558135
Cellular growth defects triggered by an overload of protein localization processes. PMID:27538565
Polarized Exocytosis Induces Compensatory Endocytosis by Sec4p-Regulated Cortical Actin Polymerization. PMID:27526190
Protective Effects of Arginine on Saccharomyces cerevisiae Against Ethanol Stress. PMID:27507154
Levels of Ycg1 Limit Condensin Function during the Cell Cycle. PMID:27463097
A genome-wide imaging-based screening to identify genes involved in synphilin-1 inclusion formation in Saccharomyces cerevisiae. PMID:27440388
Kinetic partitioning during de novo septin filament assembly creates a critical G1 "window of opportunity" for mutant septin function. PMID:27398993
Altered RNA processing and export lead to retention of mRNAs near transcription sites and nuclear pore complexes or within the nucleolus. PMID:27385342
Scan-o-matic: High-Resolution Microbial Phenomics at a Massive Scale. PMID:27371952
Spatial sequestration and detoxification of Huntingtin by the ribosome quality control complex. PMID:27033550
An extended set of yeast-based functional assays accurately identifies human disease mutations. PMID:26975778
Quantitative CRISPR interference screens in yeast identify chemical-genetic interactions and new rules for guide RNA design. PMID:26956608
Assembly, molecular organization, and membrane-binding properties of development-specific septins. PMID:26929450
One library to make them all: streamlining the creation of yeast libraries via a SWAp-Tag strategy. PMID:26928762
Viral Replication Protein Inhibits Cellular Cofilin Actin Depolymerization Factor to Regulate the Actin Network and Promote Viral Replicase Assembly. PMID:26863541
Ty1 Integrase Interacts with RNA Polymerase III-specific Subcomplexes to Promote Insertion of Ty1 Elements Upstream of Polymerase (Pol) III-transcribed Genes. PMID:26797132
Genome-wide screen uncovers novel pathways for tRNA processing and nuclear-cytoplasmic dynamics. PMID:26680305
Systematic identification and correction of annotation errors in the genetic interaction map of Saccharomyces cerevisiae. PMID:26602688
Genetic Interactions Implicating Postreplicative Repair in Okazaki Fragment Processing. PMID:26545110
Single-cell phenomics in budding yeast. PMID:26543200
Evolutionary rescue by compensatory mutations is constrained by genomic and environmental backgrounds. PMID:26459777
Mutant power: using mutant allele collections for yeast functional genomics. PMID:26453908
Genetic Networks Required to Coordinate Chromosome Replication by DNA Polymerases α, δ, and ε in Saccharomyces cerevisiae. PMID:26297725
Down-regulation of TORC2-Ypk1 signaling promotes MAPK-independent survival under hyperosmotic stress. PMID:26274562
An Updated Collection of Sequence Barcoded Temperature-Sensitive Alleles of Yeast Essential Genes. PMID:26175450
Evolution. Systematic humanization of yeast genes reveals conserved functions and genetic modularity. PMID:25999509
Differential Phosphorylation of RNA Polymerase III and the Initiation Factor TFIIIB in Saccharomyces cerevisiae. PMID:25970584
Rapid identification of chemical genetic interactions in Saccharomyces cerevisiae. PMID:25867090
Global analysis of fungal morphology exposes mechanisms of host cell escape. PMID:25824284
Genome-Wide Localization Study of Yeast Pex11 Identifies Peroxisome-Mitochondria Interactions through the ERMES Complex. PMID:25769804
The proteasomal Rpn11 metalloprotease suppresses tombusvirus RNA recombination and promotes viral replication via facilitating assembly of the viral replicase complex. PMID:25540361
Autophagy competes for a common phosphatidylethanolamine pool with major cellular PE-consuming pathways in Saccharomyces cerevisiae. PMID:25519895
Remodeling of secretory compartments creates CUPS during nutrient starvation. PMID:25512390
An evolutionary approach uncovers a diverse response of tRNA 2-thiolation to elevated temperatures in yeast. PMID:25505025
Requirement of the spindle pole body for targeting and/or tethering proteins to the inner nuclear membrane. PMID:25482124
Organelle-based aggregation and retention of damaged proteins in asymmetrically dividing cells. PMID:25417105
Stress granule-defective mutants deregulate stress responsive transcripts. PMID:25375155
Rsp5/Nedd4 is the main ubiquitin ligase that targets cytosolic misfolded proteins following heat stress. PMID:25344756
Phenomic assessment of genetic buffering by kinetic analysis of cell arrays. PMID:25213246
Tombusvirus-yeast interactions identify conserved cell-intrinsic viral restriction factors. PMID:25157258
Essential genetic interactors of SIR2 required for spatial sequestration and asymmetrical inheritance of protein aggregates. PMID:25079602
Separate responses of karyopherins to glucose and amino acid availability regulate nucleocytoplasmic transport. PMID:25057022
Healing for destruction: tRNA intron degradation in yeast is a two-step cytoplasmic process catalyzed by tRNA ligase Rlg1 and 5'-to-3' exonuclease Xrn1. PMID:25030695
Sgo1 regulates both condensin and Ipl1/Aurora B to promote chromosome biorientation. PMID:24945276
The yeast deletion collection: a decade of functional genomics. PMID:24939991
Fertility and polarized cell growth depends on eIF5A for translation of polyproline-rich formins in Saccharomyces cerevisiae. PMID:24923804
Budding yeast for budding geneticists: a primer on the Saccharomyces cerevisiae model system. PMID:24807111
The expanding functions of cellular helicases: the tombusvirus RNA replication enhancer co-opts the plant eIF4AIII-like AtRH2 and the DDX5-like AtRH5 DEAD-box RNA helicases to promote viral asymmetric RNA replication. PMID:24743583
Higher-order septin assembly is driven by GTP-promoted conformational changes: evidence from unbiased mutational analysis in Saccharomyces cerevisiae. PMID:24398420
Evaluation of the lower protein limit in the budding yeast Saccharomyces cerevisiae using TIPI-gTOW. PMID:24393197
Genome destabilizing mutator alleles drive specific mutational trajectories in Saccharomyces cerevisiae. PMID:24336748
The role of Ctk1 kinase in termination of small non-coding RNAs. PMID:24324601
Identification and characterization of functionally critical, conserved motifs in the internal repeats and N-terminal domain of yeast translation initiation factor 4B (yeIF4B). PMID:24285537
ESCRT regulates surface expression of the Kir2.1 potassium channel. PMID:24227888
Chemical suppression of defects in mitotic spindle assembly, redox control, and sterol biosynthesis by hydroxyurea. PMID:24192836
Reverse PCA, a systematic approach for identifying genes important for the physical interaction between protein pairs. PMID:24130505
A negative genetic interaction map in isogenic cancer cell lines reveals cancer cell vulnerabilities. PMID:24104479
Functional genomics in the study of yeast cell polarity: moving in the right direction. PMID:24062589
The emergence of lipid droplets in yeast: current status and experimental approaches. PMID:24057105
Identification of novel host factors via conserved domain search: Cns1 cochaperone is a novel restriction factor of tombusvirus replication in yeast. PMID:24027337
Regulation of histone gene transcription in yeast. PMID:23974242
SEACing the GAP that nEGOCiates TORC1 activation: evolutionary conservation of Rag GTPase regulation. PMID:23974112
Conserved regulators of nucleolar size revealed by global phenotypic analyses. PMID:23962978
SGAtools: one-stop analysis and visualization of array-based genetic interaction screens. PMID:23677617
Bck2 acts through the MADS box protein Mcm1 to activate cell-cycle-regulated genes in budding yeast. PMID:23675312
A Whole Genome Screen for Minisatellite Stability Genes in Stationary-Phase Yeast Cells. PMID:23550123
A rapid and sensitive non-radioactive method applicable for genome-wide analysis of Saccharomyces cerevisiae genes involved in small RNA biology. PMID:23417998
Saccharomyces cerevisiae genetics predicts candidate therapeutic genetic interactions at the mammalian replication fork. PMID:23390603
An evolutionarily conserved synthetic lethal interaction network identifies FEN1 as a broad-spectrum target for anticancer therapeutic development. PMID:23382697
The contribution of systematic approaches to characterizing the proteins and functions of the endoplasmic reticulum. PMID:23359093
Dissecting protein function: an efficient protocol for identifying separation-of-function mutations that encode structurally stable proteins. PMID:23307900
TOR and RAS pathways regulate desiccation tolerance in Saccharomyces cerevisiae. PMID:23171550
Novel checkpoint pathway organization promotes genome stability in stationary-phase yeast cells. PMID:23149941
An algorithm for chemical genomic profiling that minimizes batch effects: bucket evaluations. PMID:23009392
Interaction landscape of membrane-protein complexes in Saccharomyces cerevisiae. PMID:22940862
Chemical genetics: budding yeast as a platform for drug discovery and mapping of genetic pathways. PMID:22858845
Multiple roles for the Ess1 prolyl isomerase in the RNA polymerase II transcription cycle. PMID:22778132
Proteome-wide overexpression of host proteins for identification of factors affecting tombusvirus RNA replication: an inhibitory role of protein kinase C. PMID:22718827
Genome rearrangements caused by depletion of essential DNA replication proteins in Saccharomyces cerevisiae. PMID:22673806
Linking yeast Gcn5p catalytic function and gene regulation using a quantitative, graded dominant mutant approach. PMID:22558379
The role of the Parkinson's disease gene PARK9 in essential cellular pathways and the manganese homeostasis network in yeast. PMID:22457822
Synthetic lethality of cohesins with PARPs and replication fork mediators. PMID:22412391
A naturally thermolabile activity compromises genetic analysis of telomere function in Saccharomyces cerevisiae. PMID:22377634
Bub1 kinase and Sgo1 modulate pericentric chromatin in response to altered microtubule dynamics. PMID:22365852
Systematic identification of gene annotation errors in the widely used yeast mutation collections. PMID:22306811
R-loop-mediated genome instability in mRNA cleavage and polyadenylation mutants. PMID:22279048
Mutability and mutational spectrum of chromosome transmission fidelity genes. PMID:22198145
Neighborhood properties are important determinants of temperature sensitive mutations. PMID:22164302
GeneWeaver: a web-based system for integrative functional genomics. PMID:22080549
PhenoM: a database of morphological phenotypes caused by mutation of essential genes in Saccharomyces cerevisiae. PMID:22009677
Clathrin light chain directs endocytosis by influencing the binding of the yeast Hip1R homologue, Sla2, to F-actin. PMID:21849475
Trait variation in yeast is defined by population history. PMID:21698134
Dosage suppression genetic interaction networks enhance functional wiring diagrams of the cell. PMID:21572441
In vitro evolution goes deep. PMID:21551096 -
PhenoM: a database of morphological phenotypes caused by mutation of essential genes in Saccharomyces cerevisiae
PubMed citations: 8.
8 articles citing: PhenoM: a database of morphological phenotypes caused by mutation of essential genes in Saccharomyces cerevisiae
Systematic exploration of cell morphological phenotypes associated with a transcriptomic query. PMID:30011038
Systematic analysis of Ca2+ homeostasis in Saccharomyces cerevisiae based on chemical-genetic interaction profiles. PMID:28566553
Zebrafish behavioral profiling identifies multitarget antipsychotic-like compounds. PMID:27239787
Mutant power: using mutant allele collections for yeast functional genomics. PMID:26453908
High-throughput bacterial functional genomics in the sequencing era. PMID:26336012
Module-based construction of plasmids for chromosomal integration of the fission yeast Schizosaccharomyces pombe. PMID:26108218
CYCLoPs: A Comprehensive Database Constructed from Automated Analysis of Protein Abundance and Subcellular Localization Patterns in Saccharomyces cerevisiae. PMID:26048563
Predicting complex phenotype-genotype interactions to enable yeast engineering: Saccharomyces cerevisiae as a model organism and a cell factory. PMID:24031036 - http://dx.doi.org/10.1093/nar/GKR827
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More detailed information about this field from each metasource.
gene
metasource: Fairsharing.org
version: FAIRsharing.org: PhenoM; Phenomics of yeast Mutants; DOI: https://doi.org/10.25504/FAIRsharing.bp5hpt; Last edited: Jan. 8, 2019, 1:14 p.m.; Last accessed: Jan 03 2022 7:07 p.m.
gene ontology enrichment
metasource: Fairsharing.org
version: FAIRsharing.org: PhenoM; Phenomics of yeast Mutants; DOI: https://doi.org/10.25504/FAIRsharing.bp5hpt; Last edited: Jan. 8, 2019, 1:14 p.m.; Last accessed: Jan 03 2022 7:07 p.m.
image
metasource: Fairsharing.org
version: FAIRsharing.org: PhenoM; Phenomics of yeast Mutants; DOI: https://doi.org/10.25504/FAIRsharing.bp5hpt; Last edited: Jan. 8, 2019, 1:14 p.m.; Last accessed: Jan 03 2022 7:07 p.m.
morphology
metasource: Fairsharing.org
version: FAIRsharing.org: PhenoM; Phenomics of yeast Mutants; DOI: https://doi.org/10.25504/FAIRsharing.bp5hpt; Last edited: Jan. 8, 2019, 1:14 p.m.; Last accessed: Jan 03 2022 7:07 p.m.
mutation
metasource: Fairsharing.org
version: FAIRsharing.org: PhenoM; Phenomics of yeast Mutants; DOI: https://doi.org/10.25504/FAIRsharing.bp5hpt; Last edited: Jan. 8, 2019, 1:14 p.m.; Last accessed: Jan 03 2022 7:07 p.m.
phenotype
metasource: Fairsharing.org
version: FAIRsharing.org: PhenoM; Phenomics of yeast Mutants; DOI: https://doi.org/10.25504/FAIRsharing.bp5hpt; Last edited: Jan. 8, 2019, 1:14 p.m.; Last accessed: Jan 03 2022 7:07 p.m.
genomics databases (non-vertebrate)
metasource: Nucleic Acid Research database catalogue
version: extracted_at: 2022-11-04T11:16:25.468657
fungal genome databases
metasource: Nucleic Acid Research database catalogue
version: extracted_at: 2022-11-04T11:16:25.468657
biomolecular research
metasource: re3data.org
version: re3data.org: PhenoM; editing status 2021-08-25; re3data.org - Registry of Research Data Repositories. http://doi.org/10.17616/R3GJ5J last accessed: 2022-11-04
evolutionary genomics
metasource: re3data.org
version: re3data.org: PhenoM; editing status 2021-08-25; re3data.org - Registry of Research Data Repositories. http://doi.org/10.17616/R3GJ5J last accessed: 2022-11-04
functional genomics
metasource: re3data.org
version: re3data.org: PhenoM; editing status 2021-08-25; re3data.org - Registry of Research Data Repositories. http://doi.org/10.17616/R3GJ5J last accessed: 2022-11-04
molcecular medicine
metasource: re3data.org
version: re3data.org: PhenoM; editing status 2021-08-25; re3data.org - Registry of Research Data Repositories. http://doi.org/10.17616/R3GJ5J last accessed: 2022-11-04
proteomics
metasource: re3data.org
version: re3data.org: PhenoM; editing status 2021-08-25; re3data.org - Registry of Research Data Repositories. http://doi.org/10.17616/R3GJ5J last accessed: 2022-11-04
systems biology
metasource: re3data.org
version: re3data.org: PhenoM; editing status 2021-08-25; re3data.org - Registry of Research Data Repositories. http://doi.org/10.17616/R3GJ5J last accessed: 2022-11-04
phenomics
metasource: bio.tools
version: extracted_at: 2022-11-04T11:34:18.067086
genotype and phenotype
metasource: bio.tools
version: extracted_at: 2022-11-04T11:34:18.067086
imaging
metasource: bio.tools
version: extracted_at: 2022-11-04T11:34:18.067086
genetic variation
metasource: bio.tools
version: extracted_at: 2022-11-04T11:34:18.067086
Tags
More detailed information about this field from each metasource.
gene
metasource: Fairsharing.orgversion: FAIRsharing.org: PhenoM; Phenomics of yeast Mutants; DOI: https://doi.org/10.25504/FAIRsharing.bp5hpt; Last edited: Jan. 8, 2019, 1:14 p.m.; Last accessed: Jan 03 2022 7:07 p.m.
gene ontology enrichment
metasource: Fairsharing.orgversion: FAIRsharing.org: PhenoM; Phenomics of yeast Mutants; DOI: https://doi.org/10.25504/FAIRsharing.bp5hpt; Last edited: Jan. 8, 2019, 1:14 p.m.; Last accessed: Jan 03 2022 7:07 p.m.
image
metasource: Fairsharing.orgversion: FAIRsharing.org: PhenoM; Phenomics of yeast Mutants; DOI: https://doi.org/10.25504/FAIRsharing.bp5hpt; Last edited: Jan. 8, 2019, 1:14 p.m.; Last accessed: Jan 03 2022 7:07 p.m.
morphology
metasource: Fairsharing.orgversion: FAIRsharing.org: PhenoM; Phenomics of yeast Mutants; DOI: https://doi.org/10.25504/FAIRsharing.bp5hpt; Last edited: Jan. 8, 2019, 1:14 p.m.; Last accessed: Jan 03 2022 7:07 p.m.
mutation
metasource: Fairsharing.orgversion: FAIRsharing.org: PhenoM; Phenomics of yeast Mutants; DOI: https://doi.org/10.25504/FAIRsharing.bp5hpt; Last edited: Jan. 8, 2019, 1:14 p.m.; Last accessed: Jan 03 2022 7:07 p.m.
phenotype
metasource: Fairsharing.orgversion: FAIRsharing.org: PhenoM; Phenomics of yeast Mutants; DOI: https://doi.org/10.25504/FAIRsharing.bp5hpt; Last edited: Jan. 8, 2019, 1:14 p.m.; Last accessed: Jan 03 2022 7:07 p.m.
genomics databases (non-vertebrate)
metasource: Nucleic Acid Research database catalogueversion: extracted_at: 2022-11-04T11:16:25.468657
fungal genome databases
metasource: Nucleic Acid Research database catalogueversion: extracted_at: 2022-11-04T11:16:25.468657
biomolecular research
metasource: re3data.orgversion: re3data.org: PhenoM; editing status 2021-08-25; re3data.org - Registry of Research Data Repositories. http://doi.org/10.17616/R3GJ5J last accessed: 2022-11-04
evolutionary genomics
metasource: re3data.orgversion: re3data.org: PhenoM; editing status 2021-08-25; re3data.org - Registry of Research Data Repositories. http://doi.org/10.17616/R3GJ5J last accessed: 2022-11-04
functional genomics
metasource: re3data.orgversion: re3data.org: PhenoM; editing status 2021-08-25; re3data.org - Registry of Research Data Repositories. http://doi.org/10.17616/R3GJ5J last accessed: 2022-11-04
molcecular medicine
metasource: re3data.orgversion: re3data.org: PhenoM; editing status 2021-08-25; re3data.org - Registry of Research Data Repositories. http://doi.org/10.17616/R3GJ5J last accessed: 2022-11-04
proteomics
metasource: re3data.orgversion: re3data.org: PhenoM; editing status 2021-08-25; re3data.org - Registry of Research Data Repositories. http://doi.org/10.17616/R3GJ5J last accessed: 2022-11-04
systems biology
metasource: re3data.orgversion: re3data.org: PhenoM; editing status 2021-08-25; re3data.org - Registry of Research Data Repositories. http://doi.org/10.17616/R3GJ5J last accessed: 2022-11-04
phenomics
metasource: bio.toolsversion: extracted_at: 2022-11-04T11:34:18.067086
genotype and phenotype
metasource: bio.toolsversion: extracted_at: 2022-11-04T11:34:18.067086
imaging
metasource: bio.toolsversion: extracted_at: 2022-11-04T11:34:18.067086
genetic variation
metasource: bio.toolsversion: extracted_at: 2022-11-04T11:34:18.067086
gene gene ontology enrichment morphology mutation phenotype genomics fungal genome biomolecular research evolutionary genomics functional genomics molcecular medicine proteomics systems biology phenomics genotype and phenotype imaging genetic variation
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