The Hepatitis C Virus (HCV) sequence database is a project funded by the Division of Microbiology and Infectious Diseases of the National Institute of Allergies and Infectious Diseases (NIAID). We strive to present HCV sequences and associated data in a userfriendly way, by providing access to the central database via a web-accessible search interface and supplying a number of analysis tools. We are assisted in this effort by an editorial board, whose members serve as 'representatives' of the user community and keep us apprised of problems and issues that we might otherwise miss.