tmRDB
tmRNA is a molecule that combines functions of tRNA and mRNA in a process called trans-translation [see 1, for review] to rescue ribosomes that are stalled at the end of broken mRNA. tmRNA-like sequences have been identified in all bacteria analyzed to date including mitochondria, chloroplasts, and cyanelles. Recently, tmRNA-like molecules have been discovered also in certain bacteriphages. To assist in the study of structure and function of tmRNA, the tmRNA database (tmRDB) lists the known tmRNA sequences ordered alphabetically and phylogenetically with links to the primary sources. The tmRNA alignment, available in various formats, is the basis for supported tmRNA secondary structures. Three-dimensional models in pdb format generated by ERNA-3D [2] help to investigate potential interactions between the tmRNA and its cofactors. Aligned sequences of tmRNA-encoded tag-peptides which serve as signals for cellular proteases, are included. The tmRDB also provides relevant information about the proteins known to interact with tmRNA such as SmpB, ribosomal protein S1, alanyl-tRNA synthetase, and elongation factor Tu,. The tmRDB is maintained at the University of Texas Health Science Center at Tyler, Texas, and accessible on the World Wide Web at the URL http://psyche.uthct.edu/dbs/tmRDB/tmRDB.html. Mirror sites are located at Auburn University, Auburn, Alabama (http://www.ag.auburn.edu/mirror/tmRDB/) and the Institute of Biological Sciences, Aarhus, Denmark (http://www.bioinf.au.dk/tmRDB/).
Description
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tmRNA is a molecule that combines functions of tRNA and mRNA in a process called trans-translation [see 1, for review] to rescue ribosomes that are stalled at the end of broken mRNA. tmRNA-like sequences have been identified in all bacteria analyzed to date including mitochondria, chloroplasts, and cyanelles. Recently, tmRNA-like molecules have been discovered also in certain bacteriphages. To assist in the study of structure and function of tmRNA, the tmRNA database (tmRDB) lists the known tmRNA sequences ordered alphabetically and phylogenetically with links to the primary sources. The tmRNA alignment, available in various formats, is the basis for supported tmRNA secondary structures. Three-dimensional models in pdb format generated by ERNA-3D [2] help to investigate potential interactions between the tmRNA and its cofactors. Aligned sequences of tmRNA-encoded tag-peptides which serve as signals for cellular proteases, are included. The tmRDB also provides relevant information about the proteins known to interact with tmRNA such as SmpB, ribosomal protein S1, alanyl-tRNA synthetase, and elongation factor Tu,. The tmRDB is maintained at the University of Texas Health Science Center at Tyler, Texas, and accessible on the World Wide Web at the URL http://psyche.uthct.edu/dbs/tmRDB/tmRDB.html. Mirror sites are located at Auburn University, Auburn, Alabama (http://www.ag.auburn.edu/mirror/tmRDB/) and the Institute of Biological Sciences, Aarhus, Denmark (http://www.bioinf.au.dk/tmRDB/).
metasource: Nucleic Acid Research database catalogueversion: extracted_at: 2022-11-04T11:16:25.468657
Webpage:
http://rnp.uthscsa.edu/rnp/tmRDB/tmRDB.htmlWebpage
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http://rnp.uthscsa.edu/rnp/tmRDB/tmRDB.html
metasource: Nucleic Acid Research database catalogueversion: extracted_at: 2022-11-04T11:16:25.468657
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rna sequence databases
metasource: Nucleic Acid Research database catalogue
version: extracted_at: 2022-11-04T11:16:25.468657
Tags
More detailed information about this field from each metasource.
rna sequence databases
metasource: Nucleic Acid Research database catalogueversion: extracted_at: 2022-11-04T11:16:25.468657
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