Investigation of Interferon Gamma Activity Using Bioinformatics Methods.
PMID:35355749
The Family Keeps on Growing: Four Novel Fungal OYEs Characterized.
PMID:35328465
Detection of αB-Conotoxin VxXXIVA (αB-CTX) by ic-ELISA Based on an Epitope-Specific Monoclonal Antibody.
PMID:35324663
The MreA Metal-Binding Sites C40, H65, and C69 Play a Critical Role in the Metal Tolerance of Pseudomonas putida KT2440.
PMID:35322302
Identifying potential natural inhibitors of Brucella melitensis Methionyl-tRNA synthetase through an in-silico approach.
PMID:35312681
Genetic heterogeneity in GJB2, COL4A3, ATP6V1B1 and EDNRB variants detected among hearing impaired families in Morocco.
PMID:35301649
Phylogenetic and Expression Studies of Small GTP-Binding Proteins in Solanum lycopersicum Super Strain B.
PMID:35270112
Evolutionary history of the p53 family DNA-binding domain: insights from an Alvinella pompejana homolog.
PMID:35256607
Molecular characterization of alpha subunit 1 of sodium pump (ATP1A1) gene in Camelus dromedarius: its differential tissue expression potentially interprets the role in osmoregulation.
PMID:35235155
Novel Loss of Function Variant in BCKDK Causes a Treatable Developmental and Epileptic Encephalopathy.
PMID:35216372
Acetylation at Lysine 86 of Escherichia coli HUβ Modulates the DNA-Binding Capability of the Protein.
PMID:35185833
A Phagosomally Expressed Gene, rv0428c, of Mycobacterium tuberculosis Demonstrates Acetyl Transferase Activity and Plays a Protective Role Under Stress Conditions.
PMID:35175508
Molecular docking analysis of Clostridium perfringens beta toxin model with potential inhibitors from the ZINC database.
PMID:35173385
Molecular characterization of the serotonergic transporter from the cestode Echinococcus granulosus: pharmacology and potential role in the nervous system.
PMID:35169884
A splice altering variant in NDRG1 gene causes Charcot-Marie-Tooth disease, type 4D.
PMID:35149926
Sequence Analysis and Comparison of TCTP Proteins from Human Protozoan Parasites.
PMID:35138574
Unusual substrate specificity in GH family 12: structure-function analysis of glucanases Bgh12A and Xgh12B from Aspergillus cervinus, and Egh12 from Thielavia terrestris.
PMID:35129654
Bi-allelic variants in neuronal cell adhesion molecule cause a neurodevelopmental disorder characterized by developmental delay, hypotonia, neuropathy/spasticity.
PMID:35108495
Analytical Computation of Interleukin17A Activity in Breast Cancer Patients Using Bioinformatics Methods.
PMID:35096325
Novel Mutations in β-MYH7 Gene in Indian Patients With Dilated Cardiomyopathy.
PMID:35072022
Mutations in the helix αC of the catalytic domain from the EGFR affect its activity in cervical cancer cell lines.
PMID:35069880
Genomic characterization unravelling the causative role of SARS-CoV-2 Delta variant of lineage B.1.617.2 in 2nd wave of COVID-19 pandemic in Chhattisgarh, India.
PMID:35065253
Role of Probiotics in the Management of COVID-19: A Computational Perspective.
PMID:35057455
Circulating Phylotypes of White Spot Syndrome Virus in Bangladesh and Their Virulence.
PMID:35056639
Activity- and Enrichment-Based Metaproteomics Insights into Active Urease from the Rumen Microbiota of Cattle.
PMID:35055002
The Effects of Tetrapeptides Designed to Fit the Androgen Binding Site of ZIP9 on Myogenic and Osteogenic Cells.
PMID:35053017
NOG-Derived Peptides Can Restore Neuritogenesis on a CRASH Syndrome Cell Model.
PMID:35052783
The Preservation of PPARγ Genome Duplicates in Some Teleost Lineages: Insights into Lipid Metabolism and Xenobiotic Exploitation.
PMID:35052447
Computer-Aided Drug Design (CADD) to De-Orphanize Marine Molecules: Finding Potential Therapeutic Agents for Neurodegenerative and Cardiovascular Diseases.
PMID:35049908
Analysis of NIA and GSNOR family genes and nitric oxide homeostasis in response to wheat-leaf rust interaction.
PMID:35039546
A Peptide from Budding Yeast GAPDH Serves as a Promising Antifungal against Cryptococcus neoformans.
PMID:35019693
Inducible knockdown of Mycobacterium smegmatis MSMEG_2975 (glyoxalase II) affected bacterial growth, antibiotic susceptibility, biofilm, and transcriptome.
PMID:34964907
Mapping cross-variant neutralizing sites on the SARS-CoV-2 spike protein.
PMID:34964428
Identification of Reticulocyte Binding Domain of Plasmodium ovale curtisi Duffy Binding Protein (PocDBP) Involved in Reticulocyte Invasion.
PMID:34956929
Integrative Proteomic and Phosphoproteomic Analyses of Pattern- and Effector-Triggered Immunity in Tomato.
PMID:34925416
Toxic Peptide From Palythoa caribaeorum Acting on the TRPV1 Channel Prevents Pentylenetetrazol-Induced Epilepsy in Zebrafish Larvae.
PMID:34925021
Functional and structural analysis of non-synonymous single nucleotide polymorphisms (nsSNPs) in the MYB oncoproteins associated with human cancer.
PMID:34921182
Eruca sativa seed napin structural insights and thorough functional characterization.
PMID:34911985
Structural basis of inhibition of the human SGLT2-MAP17 glucose transporter.
PMID:34880493
Architecture of the chloroplast PSI-NDH supercomplex in Hordeum vulgare.
PMID:34879391
Red Clover HDT, a BAHD Hydroxycinnamoyl-Coenzyme A:L-3,4-Dihydroxyphenylalanine (L-DOPA) Hydroxycinnamoyl Transferase That Synthesizes Clovamide and Other N-Hydroxycinnamoyl-Aromatic Amino Acid Amides.
PMID:34868112
Gene mining, codon optimization and analysis of binding mechanism of an aldo-keto reductase with high activity, better substrate specificity and excellent solvent tolerance.
PMID:34855894
Fermentation optimization of cellulase production from sugarcane bagasse by Bacillus pseudomycoides and molecular modeling study of cellulase.
PMID:34841306
Engineering of Ocriplasmin Variants by Bioinformatics Methods for the Reduction of Proteolytic and Autolytic Activities.
PMID:34840386
Engineering a feedback inhibition-insensitive plant dihydrodipicolinate synthase to increase lysine content in Camelina sativa seeds.
PMID:34802109
Phosphoinositide regulates dynamic movement of the S4 voltage sensor in the second repeat in two-pore channel 3.
PMID:34800436
MSMEG_3955 from Mycobacterium smegmatis is a FMN bounded homotrimeric NAD(P)H:Flavin mononucleotide (FMN) oxidoreductase.
PMID:34798816
Modified Rhodopsins From Aureobasidium pullulans Excel With Very High Proton-Transport Rates.
PMID:34790700
Structure, function and pharmacology of human itch receptor complexes.
PMID:34789875
Decreased Methylenetetrahydrofolate Reductase Activity Leads to Increased Sensitivity to para-Aminosalicylic Acid in Mycobacterium tuberculosis.
PMID:34780266
New Antagonists of the Membrane Androgen Receptor OXER1 from the ZINC Natural Product Database.
PMID:34778638
Bio-Mechanism of Catechin as Pheromone Signal Inhibitor: Prediction of Antibacterial Agent Action Mode by In Vitro and In Silico Study.
PMID:34770790
Characterization of a new type of neuronal 5-HT G- protein coupled receptor in the cestode nervous system.
PMID:34762657
Structure of the hexameric fungal plasma membrane proton pump in its autoinhibited state.
PMID:34757782
Evolution of the Cytokinin Dehydrogenase (CKX) Domain.
PMID:34757471
Genomic diversity and molecular dynamics interaction on mutational variances among RB domains of SARS-CoV-2 interplay drug inactivation.
PMID:34752930
The Role of Ku70 as a Cytosolic DNA Sensor in Innate Immunity and Beyond.
PMID:34746031
Distance-based reconstruction of protein quaternary structures from inter-chain contacts.
PMID:34716620
Kinetic proofreading of lipochitooligosaccharides determines signal activation of symbiotic plant receptors.
PMID:34716271
Pan-ebolavirus protective therapy by two multifunctional human antibodies.
PMID:34715022
TwinCons: Conservation score for uncovering deep sequence similarity and divergence.
PMID:34714829
A conserved Neurite Outgrowth and Guidance motif with biomimetic potential in neuronal Cell Adhesion Molecules.
PMID:34712402
The conformational cycle of prestin underlies outer-hair cell electromotility.
PMID:34695838
GRP78: A possible relationship of COVID-19 and the mucormycosis; in silico perspective.
PMID:34695683
Computational Analysis of Missense Variants in the Human Transmembrane Protease Serine 2 (TMPRSS2) and SARS-CoV-2.
PMID:34692848
Staphylococcusaureus Transcriptome Data and Metabolic Modelling Investigate the Interplay of Ser/Thr Kinase PknB, Its Phosphatase Stp, the glmR/yvcK Regulon and the cdaA Operon for Metabolic Adaptation.
PMID:34683468
TMEM16A, a Homoharringtonine Receptor, as a Potential Endogenic Target for Lung Cancer Treatment.
PMID:34681590
Discovery of a Novel Tetrapeptide against Influenza A Virus: Rational Design, Synthesis, Bioactivity Evaluation and Computational Studies.
PMID:34681184
Identification, Molecular Characterization, and Tissue Expression Profiles of Three Smad Genes from Water Buffalo (Bubalus bubalis).
PMID:34680931
Structural basis of cytokine-mediated activation of ALK family receptors.
PMID:34646012
Novel Antimicrobial Peptides from a Cecropin-Like Region of Heteroscorpine-1 from Heterometrus laoticus Venom with Membrane Disruption Activity.
PMID:34641415
In-silico evidence for enhancement of avian influenza virus H9N2 virulence by modulation of its hemagglutinin (HA) antigen function and stability during co-infection with infectious bronchitis virus in chickens.
PMID:34631979
Genome of Ganoderma Species Provides Insights Into the Evolution, Conifers Substrate Utilization, and Terpene Synthesis for Ganoderma tsugae.
PMID:34603250
Molecular and genetic characterization of a large Brazilian cohort presenting hearing loss.
PMID:34599368
Importance of Anion-π Interactions in RNA GAAA and GGAG Tetraloops: A Combined MD and QM Study.
PMID:34586810
Evaluation of the relationship between the 14-3-3ε protein and LvRab11 in the shrimp Litopenaeus vannamei during WSSV infection.
PMID:34584112
Naproxen Based 1,3,4-Oxadiazole Derivatives as EGFR Inhibitors: Design, Synthesis, Anticancer, and Computational Studies.
PMID:34577570
Antimalarial Inhibitors Targeting Epigenetics or Mitochondria in Plasmodium falciparum: Recent Survey upon Synthesis and Biological Evaluation of Potential Drugs against Malaria.
PMID:34577183
Exploring the immune evasion of SARS-CoV-2 variant harboring E484K by molecular dynamics simulations.
PMID:34553217
Bacteriophage origin of some minimal ATP-dependent DNA ligases: a new structure from Burkholderia pseudomallei with striking similarity to Chlorella virus ligase.
PMID:34548548
Genetic modification of Gossypium arboreum universal stress protein (GUSP1) improves drought tolerance in transgenic cotton (Gossypium hirsutum).
PMID:34539116
Genome-wide detection and classification of terpene synthase genes in Aquilaria agallochum.
PMID:34539112
Structural basis of human transcription-DNA repair coupling.
PMID:34526721
Exploration of antigenic determinants in spike glycoprotein of SARS-CoV2 and identification of five salient potential epitopes.
PMID:34514073
DeepComplex: A Web Server of Predicting Protein Complex Structures by Deep Learning Inter-chain Contact Prediction and Distance-Based Modelling.
PMID:34497831
Ser253Leu substitution in PmrB contributes to colistin resistance in clinical Acinetobacter nosocomialis.
PMID:34468294
Wheat pathogen Zymoseptoria tritici N-myristoyltransferase inhibitors: on-target antifungal activity and an unusual metabolic defense mechanism.
PMID:34458749
Quercetin and/or Ascorbic Acid Modulatory Effect on Phenobarbital-Induced Sleeping Mice Possibly through GABAA and GABAB Receptor Interaction Pathway.
PMID:34451819
Modeling and Structure Determination of Homo-Oligomeric Proteins: An Overview of Challenges and Current Approaches.
PMID:34445785
Cytotoxicity of Frutalin on Distinct Cancer Cells Is Independent of Its Glycosylation.
PMID:34443300
Fates of Sec, Tat, and YidC Translocases in Mitochondria and Other Eukaryotic Compartments.
PMID:34436602
Kinetic studies and homology modeling of a dual-substrate linalool/nerolidol synthase from Plectranthus amboinicus.
PMID:34429465
Unraveling the functions of uncharacterized transcription factors in Escherichia coli using ChIP-exo.
PMID:34428301
The structure and flexibility analysis of the Arabidopsis synaptotagmin 1 reveal the basis of its regulation at membrane contact sites.
PMID:34408000
Inverse molecular docking reveals a novel function of thymol: Inhibition of fat deposition induced by high-dose glucose in Caenorhabditis elegans.
PMID:34401075
Molecular Characterization and Elucidation of Pathways to Identify Novel Therapeutic Targets in Pulmonary Arterial Hypertension.
PMID:34366885
Identification and expression profiling of proline metabolizing genes in Arabidopsis thaliana and Oryza sativa to reveal their stress-specific transcript alteration.
PMID:34366590
Cardiolipin-Containing Lipid Membranes Attract the Bacterial Cell Division Protein DivIVA.
PMID:34361115
Protein Model and Function Analysis in Quorum-Sensing Pathway of Vibrio qinghaiensis sp.-Q67.
PMID:34356493
Improved machine learning scoring functions for identification of Electrophorus electricus's acetylcholinesterase inhibitors.
PMID:34328603
A secondary structure-based position-specific scoring matrix applied to the improvement in protein secondary structure prediction.
PMID:34320027
The Fish Pathogen Aliivibrio salmonicida LFI1238 Can Degrade and Metabolize Chitin despite Gene Disruption in the Chitinolytic Pathway.
PMID:34319813
A distinct assembly pathway of the human 39S late pre-mitoribosome.
PMID:34315873
A pan-cancer analysis of alternative splicing of splicing factors in 6904 patients.
PMID:34285345
Comparative analysis of two paradigm bacteriophytochromes reveals opposite functionalities in two-component signaling.
PMID:34285211
Co-culturing experiments reveal the uptake of myo-inositol phosphate synthase (EC 5.5.1.4) in an inositol auxotroph of Saccharomyces cerevisiae.
PMID:34281557
The influence of dataset homology and a rigorous evaluation strategy on protein secondary structure prediction.
PMID:34260641
Multi-Omics Approach Reveals the Potential Core Vaccine Targets for the Emerging Foodborne Pathogen Campylobacter jejuni.
PMID:34248875
Molecular characterization and nutritional regulation of sodium-dependent glucose cotransporter 1 (Sglt1) in blunt snout bream (Megalobrama amblycephala).
PMID:34234240
Receptor Switching in Newly Evolved Adeno-associated Viruses.
PMID:34232726
Repurposing proteases: An in-silico analysis of the binding potential of extracellular fungal proteases with selected viral proteins.
PMID:34226889
NMR structure of the Vibrio vulnificus ribosomal protein S1 domains D3 and D4 provides insights into molecular recognition of single-stranded RNAs.
PMID:34223902
The protective effects of the methylenetetrahydrofolate reductase rs1801131 variant among Saudi smokers.
PMID:34220254
Identification of a novel B cell epitope on the nucleocapsid protein of porcine deltacoronavirus.
PMID:34217778
Antiviral Activity of Metabolites from Peruvian Plants against SARS-CoV-2: An In Silico Approach.
PMID:34202092
Identification of Glutathione S-Transferase Genes in Hami Melon (Cucumis melo var. saccharinus) and Their Expression Analysis Under Cold Stress.
PMID:34168669
Gene and Phenotype Expansion of Unexplained Early Infantile Epileptic Encephalopathy.
PMID:34163418
Structure of AMH bound to AMHR2 provides insight into a unique signaling pair in the TGF-β family.
PMID:34155118
A chromosome-level Camptotheca acuminata genome assembly provides insights into the evolutionary origin of camptothecin biosynthesis.
PMID:34112794
Bioinformatics Structural and Phylogenetic Characterization of Entamoeba histolytica Alcohol Dehydrogenase 2 (EhADH2).
PMID:34103738
Delayed diagnosis of Peutz-Jeghers syndrome due to pathological information loss or mistake in family/personal history.
PMID:34103092
Self-sufficient asymmetric reduction of β-ketoesters catalysed by a novel and robust thermophilic alcohol dehydrogenase co-immobilised with NADH.
PMID:34094502
Identification of Rice Blast Loss-of-Function Mutant Alleles in the Wheat Genome as a New Strategy for Wheat Blast Resistance Breeding.
PMID:34093638
The higBA-Type Toxin-Antitoxin System in IncC Plasmids Is a Mobilizable Ciprofloxacin-Inducible System.
PMID:34077263
Exploring the biosynthetic pathway of lignin in Acorus tatarinowii Schott using de novo leaf and rhizome transcriptome analysis.
PMID:34076245
NF-YB-Mediated Active Responses of Plant Growth under Salt and Temperature Stress in Eucalyptus grandis.
PMID:34072675
Dasatinib-SIK2 Binding Elucidated by Homology Modeling, Molecular Docking, and Dynamics Simulations.
PMID:34056256
Analysis of diverse eukaryotes suggests the existence of an ancestral mitochondrial apparatus derived from the bacterial type II secretion system.
PMID:34011950
Voltage-clamp fluorometry analysis of structural rearrangements of ATP-gated channel P2X2 upon hyperpolarization.
PMID:34009126
Biochemical and structural insights into Rab12 interactions with RILP and its family members.
PMID:33986343
Computational Methods for the Elucidation of Protein Structure and Interactions.
PMID:33950383
Effectiveness of Bioactive Compound as Antibacterial and Anti-Quorum Sensing Agent from Myrmecodia pendans: An In Silico Study.
PMID:33922641
Molecular Dynamics Simulations Based on 1-Phenyl-4-Benzoyl-1-Hydro-Triazole ERRα Inverse Agonists.
PMID:33918423
The OSMR Gene Is Involved in Hirschsprung Associated Enterocolitis Susceptibility through an Altered Downstream Signaling.
PMID:33917126
Diaphorina citri Genome Possesses a Complete Melatonin Biosynthesis Pathway Differentially Expressed under the Influence of the Phytopathogenic Bacterium, Candidatus Liberibacter asiaticus.
PMID:33916117
The structure of MgtE in the absence of magnesium provides new insights into channel gating.
PMID:33905418
Structure-Based Virtual Screening to Identify Novel Potential Compound as an Alternative to Remdesivir to Overcome the RdRp Protein Mutations in SARS-CoV-2.
PMID:33898520
Enhanced Glutamate Synthesis and Export by the Thermotolerant Emerging Industrial Workhorse Bacillus methanolicus in Response to High Osmolarity.
PMID:33897645
In Silico Analysis of High-Risk Missense Variants in Human ACE2 Gene and Susceptibility to SARS-CoV-2 Infection.
PMID:33884270
Genomic Evolution and Variation of SARS-CoV-2 in the Early Phase of COVID-19 Pandemic in Guangdong Province, China.
PMID:33877539
Accurate contact-based modelling of repeat proteins predicts the structure of new repeats protein families.
PMID:33857128
Convergence of a common solution for broad ebolavirus neutralization by glycan cap-directed human antibodies.
PMID:33852862
In Silico Approach for Phytocompound-Based Drug Designing to Fight Efflux Pump-Mediated Multidrug-Resistant Mycobacterium tuberculosis.
PMID:33826064
Epitope-directed monoclonal antibody production using a mixed antigen cocktail facilitates antibody characterization and validation.
PMID:33824395
Integrative omics identification, evolutionary and structural analysis of low affinity nitrate transporters in diatoms, diNPFs.
PMID:33823659
Unravelling Regioselectivity of Leuconostoc citreum ABK-1 Alternansucrase by Acceptor Site Engineering.
PMID:33810084
Molecular Modeling of Histamine Receptors-Recent Advances in Drug Discovery.
PMID:33810008
3-Hydroxypropane-1,2-Diyl Dipalmitoleate-A Natural Compound with Dual Roles (CB1 Agonist/FAAH1 Blocker) in Inhibiting Ovarian Cancer Cell Line.
PMID:33809034
Saccharomyces cerevisiae as a Toolkit for COP9 Signalosome Research.
PMID:33806190
Actin-Resistant DNase1L2 as a Potential Therapeutics for CF Lung Disease.
PMID:33802146
Brassinosteroid homeostasis is critical for the functionality of the Medicago truncatula pulvinus.
PMID:33793936
In silico studies of selected multi-drug targeting against 3CLpro and nsp12 RNA-dependent RNA-polymerase proteins of SARS-CoV-2 and SARS-CoV.
PMID:33786291
Structural-genetic insight and optimization of protease production from a novel strain of Aeromonas veronii CMF, a gut isolate of Chrysomya megacephala.
PMID:33772325
Identification and functional characterization of odorant-binding proteins 69a and 76a of Drosophila suzukii.
PMID:33748486
Autosomal Recessive Rod-Cone Dystrophy Associated With Compound Heterozygous Variants in ARL3 Gene.
PMID:33748123
Spinocerebellar ataxia type 14: refining clinicogenetic diagnosis in a rare adult-onset disorder.
PMID:33739604
Kinetic analysis of ASIC1a delineates conformational signaling from proton-sensing domains to the channel gate.
PMID:33729158
A novel missense variant in TRAPPC2 causes X-linked spondyloepiphyseal dysplasia tarda: A case report.
PMID:33726005
Natural combinatorial genetics and prolific polyamine production enable siderophore diversification in Serratia plymuthica.
PMID:33722216
Cartilage Oligomeric Matrix Protein Induced Arthritis-A New Model for Rheumatoid Arthritis in the C57BL/6 Mouse.
PMID:33708221
Immunoinformatic analysis of structural and epitope variations in the spike and Orf8 proteins of SARS-CoV-2/B.1.1.7.
PMID:33704818
Structural basis for VPS34 kinase activation by Rab1 and Rab5 on membranes.
PMID:33692360
Expression, Characterization and Its Deinking Potential of a Thermostable Xylanase From Planomicrobium glaciei CHR43.
PMID:33681158
Inhibition of Pyruvate Kinase From Thermoanaerobacterium saccharolyticum by IMP Is Independent of the Extra-C Domain.
PMID:33679651
Purification and cryoelectron microscopy structure determination of human V-ATPase.
PMID:33665630
In silico designing of putative peptides for targeting pathological protein Htt in Huntington's disease.
PMID:33659724
Apigenin Attenuates Acetaminophen-Induced Hepatotoxicity by Activating AMP-Activated Protein Kinase/Carnitine Palmitoyltransferase I Pathway.
PMID:33658919
The soybean (Glycine max L.) cytokinin oxidase/dehydrogenase multigene family; Identification of natural variations for altered cytokinin content and seed yield.
PMID:33644633
Exposure of human intestinal epithelial cells and primary human hepatocytes to trypsin-like serine protease inhibitors with potential antiviral effect.
PMID:33641565
Iris domestica (iso)flavone 7- and 3'-O-Glycosyltransferases Can Be Induced by CuCl2.
PMID:33633770
Identification of Stress-Related Genes and a Comparative Analysis of the Amino Acid Compositions of Translated Coding Sequences Based on Draft Genome Sequences of Antarctic Yeasts.
PMID:33633709
Effects of Conserved Wedge Domain Residues on DNA Binding Activity of Deinococcus radiodurans RecG Helicase.
PMID:33613647
Genome-wide identification and expression profiling of glutathione S-transferase family under multiple abiotic and biotic stresses in Medicago truncatula L.
PMID:33606812
Bacillus aryabhattai TFG5-mediated synthesis of humic substances from coir pith wastes.
PMID:33596930
A novel mutation in the cathepsin C (CTSC) gene in Iranian family with Papillon-Lefevre syndrome.
PMID:33586345
Plant drought tolerance provided through genome editing of the trehalase gene.
PMID:33570447
Novel Roles of the N1 Loop and N4 Alpha-Helical Region of the Nipah Virus Fusion Glycoprotein in Modulating Early and Late Steps of the Membrane Fusion Cascade.
PMID:33568505
The CRK2-CYC13 complex functions as an S-phase cyclin-dependent kinase to promote DNA replication in Trypanosoma brucei.
PMID:33568178
Structural insights into the regulation of human serine palmitoyltransferase complexes.
PMID:33558761
Effect of mutation at oxyanion hole residu (H110F) on activity of Lk4 lipase.
PMID:33532247
Strategic aromatic residues in the catalytic cleft of the xyloglucanase MtXgh74 modifying thermostability, mode of enzyme action, and viscosity reduction ability.
PMID:33521846
Identification and characterisation of putative drug binding sites in human ATP-binding cassette B5 (ABCB5) transporter.
PMID:33510870
W196 and the β-Hairpin Motif Modulate the Redox Switch of Conformation and the Biomolecular Interaction Network of the Apoptosis-Inducing Factor.
PMID:33510840
Genome-Wide Identification and Analysis of Chitinase GH18 Gene Family in Mycogone perniciosa.
PMID:33505368
Glutamine Uptake via SNAT6 and Caveolin Regulates Glutamine-Glutamate Cycle.
PMID:33503881
Influenza A Virus Hemagglutinin and Other Pathogen Glycoprotein Interactions with NK Cell Natural Cytotoxicity Receptors NKp46, NKp44, and NKp30.
PMID:33494528
Bioaccessibility and In Vitro Intestinal Permeability of a Recombinant Lectin from Tepary Bean (Phaseolus acutifolius) Using the Everted Intestine Assay.
PMID:33494324
Chimeric Cellobiose Dehydrogenases Reveal the Function of Cytochrome Domain Mobility for the Electron Transfer to Lytic Polysaccharide Monooxygenase.
PMID:33489432
Immuno-informatics approach for B-cell and T-cell epitope based peptide vaccine design against novel COVID-19 virus.
PMID:33478787
Novel nucleocytoplasmic protein O-fucosylation by SPINDLY regulates diverse developmental processes in plants.
PMID:33476897
Completion of the AAV Structural Atlas: Serotype Capsid Structures Reveals Clade-Specific Features.
PMID:33450892
Generation and functional characterization of a single-chain variable fragment (scFv) of the anti-FGF2 3F12E7 monoclonal antibody.
PMID:33446839
Characterization of sucrose non-fermenting-1 (SNF1) homologue gene in Fusarium udum WSP-V2 and its regulation by the biocontrol agent Pseudomonas fluorescens OKC.
PMID:33442517
Transcription Inhibitors with XRE DNA-Binding and Cupin Signal-Sensing Domains Drive Metabolic Diversification in Pseudomonas.
PMID:33436508
Development and structural basis of a two-MAb cocktail for treating SARS-CoV-2 infections.
PMID:33431876
Towards reproducible computational drug discovery.
PMID:33430992
Identification and Functional Assessment of the First Placental Adhesin of Treponema pallidum That May Play Critical Role in Congenital Syphilis.
PMID:33408711
Identification of a novel mutation in the KITLG gene in a Chinese family with familial progressive hyper- and hypopigmentation.
PMID:33407466
Functional Prediction and Assignment of Methanobrevibacter ruminantium M1 Operome Using a Combined Bioinformatics Approach.
PMID:33391347
OsMre11 Is Required for Mitosis during Rice Growth and Development.
PMID:33375295
Genetic background and PfKelch13 affect artemisinin susceptibility of PfCoronin mutants in Plasmodium falciparum.
PMID:33370279
Molecular simulation of the Kv7.4[ΔS269] mutant channel reveals that ion conduction in the cavity is perturbed due to hydrophobic gating.
PMID:33367117
Spike Proteins of SARS-CoV and SARS-CoV-2 Utilize Different Mechanisms to Bind With Human ACE2.
PMID:33363207
Antifungal Effect of All-trans Retinoic Acid against Aspergillus fumigatus In Vitro and in a Pulmonary Aspergillosis In Vivo Model.
PMID:33361288
Generation of 4-vinylguaiacol through a novel high-affinity ferulic acid decarboxylase to obtain smoke flavours without carcinogenic contaminants.
PMID:33347481
Pentafluoro-3-hydroxy-pent-2-en-1-ones Potently Inhibit FNT-Type Lactate Transporters from all Five Human-Pathogenic Plasmodium Species.
PMID:33336890
Different mutations at position 562 of the hepatitis E virus capsid proteins exhibit differential effects on viral neutralizing activity.
PMID:33335573
Membrane Proteocomplexome of Campylobacter jejuni Using 2-D Blue Native/SDS-PAGE Combined to Bioinformatics Analysis.
PMID:33329413
Efficient photoactivatable Dre recombinase for cell type-specific spatiotemporal control of genome engineering in the mouse.
PMID:33318209
SLC2A12 of SLC2 Gene Family in Bird Provides Functional Compensation for the Loss of SLC2A4 Gene in Other Vertebrates.
PMID:33316072
Ritonavir may inhibit exoribonuclease activity of nsp14 from the SARS-CoV-2 virus and potentiate the activity of chain terminating drugs.
PMID:33309661
Mutational Analysis of Ocriplasmin to Reduce Proteolytic and Autolytic Activity in Pichia pastoris.
PMID:33308171
Homology modeling in the time of collective and artificial intelligence.
PMID:33304450
Bioinformatic analysis and functional predictions of selected regeneration-associated transcripts expressed by zebrafish microglia.
PMID:33287696
Sodium-bile acid co-transporter is crucial for survival of a carcinogenic liver fluke Clonorchis sinensis in the bile.
PMID:33284789
Identification of Potential Key Agents for Targeting RNA-Dependent RNA Polymerase of SARS-CoV-2 by Integrated Analysis and Virtual Drug Screening.
PMID:33281876
USP24 stabilizes bromodomain containing proteins to promote lung cancer malignancy.
PMID:33257797
Multiple functions of TBCK protein in neurodevelopment disorders and tumors.
PMID:33240423
In silico studies evidenced the role of structurally diverse plant secondary metabolites in reducing SARS-CoV-2 pathogenesis.
PMID:33239694
Target-Centered Drug Repurposing Predictions of Human Angiotensin-Converting Enzyme 2 (ACE2) and Transmembrane Protease Serine Subtype 2 (TMPRSS2) Interacting Approved Drugs for Coronavirus Disease 2019 (COVID-19) Treatment through a Drug-Target Interaction Deep Learning Model.
PMID:33218024
Fungal Shaker-like channels beyond cellular K+ homeostasis: A role in ectomycorrhizal symbiosis between Hebeloma cylindrosporum and Pinus pinaster.
PMID:33216794
TCMP-2 affects tomato flowering and interacts with BBX16, a homolog of the arabidopsis B-box MiP1b.
PMID:33204936
Antifungal Drug Repurposing.
PMID:33203147
Structure-Based Design of Acetolactate Synthase From Bacillus licheniformis Improved Protein Stability Under Acidic Conditions.
PMID:33193222
Isolation and thermal stabilization of mouse ferroportin.
PMID:33190422
Functional Cross-Talk of MbtH-Like Proteins During Thaxtomin Biosynthesis in the Potato Common Scab Pathogen Streptomyces scabiei.
PMID:33178168
Functional Characterization of Facilitative Glucose Transporter 4 With a Delay Responding to Plasma Glucose Level in Blunt Snout Bream (Megalobrama amblycephala).
PMID:33178047
RNA-seq analysis identifies cytoskeletal structural genes and pathways for meat quality in beef.
PMID:33175867
Computational Study of the Ion and Water Permeation and Transport Mechanisms of the SARS-CoV-2 Pentameric E Protein Channel.
PMID:33173781
A clinically relevant polymorphism in the Na+/taurocholate cotransporting polypeptide (NTCP) occurs at a rheostat position.
PMID:33168628
The Post-Translational Modifications, Localization, and Mode of Attachment of Non-Covalently Bound Glucanosyltransglycosylases of Yeast Cell Wall as a Key to Understanding their Functioning.
PMID:33167499
Polymorphisms in STING Affect Human Innate Immune Responses to Poxviruses.
PMID:33154747
When a foreign gene meets its native counterpart: computational biophysics analysis of two PgiC loci in the grass Festuca ovina.
PMID:33127989
Citronellal perception and transmission by Anopheles gambiae s.s. (Diptera: Culicidae) females.
PMID:33122679
Preventing Candida albicans from subverting host plasminogen for invasive infection treatment.
PMID:33115324
Applying computer simulations in battling with COVID-19, using pre-analyzed molecular and chemical data to face the pandemic.
PMID:33102687
Investigating the Role of the N-Terminal Loop of PD-1 in Binding Process Between PD-1 and Nivolumab via Molecular Dynamics Simulation.
PMID:33102523
A putative chordate luciferase from a cosmopolitan tunicate indicates convergent bioluminescence evolution across phyla.
PMID:33082360
Functional Characterization of Alr0765, A Hypothetical Protein from Anabaena PCC 7120 Involved in Cellular Energy Status Sensing, Iron Acquisition and Abiotic Stress Management in E. coli Using Molecular, Biochemical and Computational Approaches.
PMID:33071622
Structures of a Complete Human V-ATPase Reveal Mechanisms of Its Assembly.
PMID:33065002
Cyclodextrin inclusion complex inhibits circulating galectin-3 and FGF-7 and affects the reproductive integrity and mobility of Caco-2 cells.
PMID:33060727
Site-Specific Mutations of GalR Affect Galactose Metabolism in Streptococcus pneumoniae.
PMID:33046563
Chilling Stress Triggers VvAgo1-Mediated miRNA-Like RNA Biogenesis in Volvariella volvacea.
PMID:33042047
Anti-quorum sensing activity of some marine bacteria isolated from different marine resources in Egypt.
PMID:33034782
Bacterial genome-wide association study of hyper-virulent pneumococcal serotype 1 identifies genetic variation associated with neurotropism.
PMID:33033372
Comparative genomics of Clostridioides difficile toxinotypes identifies module-based toxin gene evolution.
PMID:33030421
Cryo-EM structure of the deltaretroviral intasome in complex with the PP2A regulatory subunit B56γ.
PMID:33028863
Identification of transcobalamin deficiency with two novel mutations in the TCN2 gene in a Chinese girl with abnormal immunity: a case report.
PMID:33023511
Modular and coordinated activity of AAA+ active sites in the double-ring ClpA unfoldase of the ClpAP protease.
PMID:33020301
A Missense Mutation in a Large Subunit of Ribonucleotide Reductase Confers Temperature-Gated Tassel Formation.
PMID:33020253
Revised annotation and extended characterizations of components of the Chlamydomonas reinhardtii SUMOylation system.
PMID:33015534
Novel phospho-switch function of delta-catenin in dendrite development.
PMID:33007084
First hybrid complete genome of Aeromonas veronii reveals chromosome-mediated novel structural variant mcr-3.30 from a human clinical sample.
PMID:33005867
Biochemical characterization of a glycosyltransferase Gtf3 from Mycobacterium smegmatis: a case study of improved protein solubilization.
PMID:32999813
Genetic variation and selection in the major histocompatibility complex Class II gene in the Guizhou pony.
PMID:32999762
Cross-Protection by Inactivated H5 Prepandemic Vaccine Seed Strains against Diverse Goose/Guangdong Lineage H5N1 Highly Pathogenic Avian Influenza Viruses.
PMID:32999029
Investigating the structural impacts of a novel missense variant identified with whole exome sequencing in an Egyptian patient with propionic acidemia.
PMID:32995289
Directed Evolution of Pseudomonas fluorescens Lipase Variants With Improved Thermostability Using Error-Prone PCR.
PMID:32984290
Kinetic and structural insights into enzymatic mechanism of succinic semialdehyde dehydrogenase from Cyanothece sp. ATCC51142.
PMID:32966327
Plant Antimicrobial Peptides: State of the Art, In Silico Prediction and Perspectives in the Omics Era.
PMID:32952397
Model prediction of a Kunitz-type trypsin inhibitor protein from seeds of Acacia nilotica L. with strong antimicrobial and insecticidal activity.
PMID:32922126
Structural characterization and computational analysis of PDZ domains in Monosiga brevicollis.
PMID:32914530
Evolution of dependoparvoviruses across geological timescales-implications for design of AAV-based gene therapy vectors.
PMID:32913662
Pathogenic impact of transcript isoform switching in 1,209 cancer samples covering 27 cancer types using an isoform-specific interaction network.
PMID:32879328
Mapping the immunogenic landscape of near-native HIV-1 envelope trimers in non-human primates.
PMID:32866207
Enhancing cellulosic ethanol production through coevolution of multiple enzymatic characteristics of β-glucosidase from Penicillium oxalicum 16.
PMID:32857198
Functional characterization of the chlorzoxazone 6-hydroxylation activity of human cytochrome P450 2E1 allelic variants in Han Chinese.
PMID:32821545
Alternative N-terminal regions of Drosophila myosin heavy chain II regulate communication of the purine binding loop with the essential light chain.
PMID:32817166
Vitamin B12 may inhibit RNA-dependent-RNA polymerase activity of nsp12 from the SARS-CoV-2 virus.
PMID:32812340
Synthesis, molecular docking and molecular dynamic simulation studies of 2-chloro-5-[(4-chlorophenyl)sulfamoyl]-N-(alkyl/aryl)-4-nitrobenzamide derivatives as antidiabetic agents.
PMID:32789301
Structure and mechanism of CutA, RNA nucleotidyl transferase with an unusual preference for cytosine.
PMID:32785623
Inhibition of TMPRSS2 by HAI-2 reduces prostate cancer cell invasion and metastasis.
PMID:32778768
Use Chou's 5-Step Rule to Predict DNA-Binding Proteins with Evolutionary Information.
PMID:32775434
Molecular Dynamics Simulations of Mite Aquaporin DerfAQP1 from the Dust Mite Dermatophagoides farinae (Acariformes: Pyroglyphidae).
PMID:32775433
First description of betalains biosynthesis in an aquatic organism: characterization of 4,5-DOPA-extradiol-dioxygenase activity in the cyanobacteria Anabaena cylindrica.
PMID:32767544
Mutation of TWNK Gene Is One of the Reasons of Runting and Stunting Syndrome Characterized by mtDNA Depletion in Sex-Linked Dwarf Chicken.
PMID:32766243
PSCs Reveal PUFA-Provoked Mitochondrial Stress as a Central Node Potentiating RPE Degeneration in Bietti's Crystalline Dystrophy.
PMID:32755565
Vaccine candidate designed against carcinoembryonic antigen-related cell adhesion molecules using immunoinformatics tools.
PMID:32720576
Modulation of Light Energy Transfer from Chromophore to Protein in the Channelrhodopsin ReaChR.
PMID:32697975
Structure and function of yeast Lso2 and human CCDC124 bound to hibernating ribosomes.
PMID:32687489
Novel susceptibility loci for A(H7N9) infection identified by next generation sequencing and functional analysis.
PMID:32678187
Computer-aided screening for potential TMPRSS2 inhibitors: a combination of pharmacophore modeling, molecular docking and molecular dynamics simulation approaches.
PMID:32672528
Third Helical Domain of the Nipah Virus Fusion Glycoprotein Modulates both Early and Late Steps in the Membrane Fusion Cascade.
PMID:32669342
A simple open source bioinformatic methodology for initial exploration of GPCR ligands' agonistic/antagonistic properties.
PMID:32662237
A Novel Small-Molecule Inhibitor of Endosomal TLRs Reduces Inflammation and Alleviates Autoimmune Disease Symptoms in Murine Models.
PMID:32660060
Using Random Forest Model Combined With Gabor Feature to Predict Protein-Protein Interaction From Protein Sequence.
PMID:32655275
ASGR1 and Its Enigmatic Relative, CLEC10A.
PMID:32650396
Generation and characterization of LPA-KIV9, a murine monoclonal antibody binding a single site on apolipoprotein (a).
PMID:32641432
Leveraging Systematic Functional Analysis to Benchmark an In Silico Framework Distinguishes Driver from Passenger MEK Mutants in Cancer.
PMID:32641410
Structural modeling, mutation analysis, and in vitro expression of usherin, a major protein in inherited retinal degeneration and hearing loss.
PMID:32637036
Effect of Vitamin K3 Inhibiting the Function of NorA Efflux Pump and Its Gene Expression on Staphylococcus aureus.
PMID:32630491
N-Ribosyltransferase From Archaeoglobus veneficus: A Novel Halotolerant and Thermostable Biocatalyst for the Synthesis of Purine Ribonucleoside Analogs.
PMID:32612982
Structural and Functional Characteristics of Two Molecular Variants of the Nitrogen Sensor PII in Maritime Pine.
PMID:32612622
Computational Chemogenomics Drug Repositioning Strategy Enables the Discovery of Epirubicin as a New Repurposed Hit for Plasmodium falciparum and P. vivax.
PMID:32601162
Potential of MurA Enzyme and GBAP in Fsr Quorum Sensing System as Antibacterial Drugs Target: In vitro and In silico Study of Antibacterial Compounds from Myrmecodia pendans.
PMID:32598250
Homology Modeling of Leishmanolysin (gp63) from Leishmania panamensis and Molecular Docking of Flavonoids.
PMID:32596611
Co-evolution of β-glucosidase activity and product tolerance for increasing cellulosic ethanol yield.
PMID:32583369
Functional Characterization of a Novel IRF6 Frameshift Mutation From a Van Der Woude Syndrome Family.
PMID:32582293
A novel loss-of-function mutation of PBK associated with human kidney stone disease.
PMID:32581305
Heterozygous mutations in ZP1 and ZP3 cause formation disorder of ZP and female infertility in human.
PMID:32573113
E1784K, the most common Brugada syndrome and long-QT syndrome type 3 mutant, disrupts sodium channel inactivation through two separate mechanisms.
PMID:32569350
High flavivirus structural plasticity demonstrated by a non-spherical morphological variant.
PMID:32561757
Structural Characterization of Cuta- and Tusavirus: Insight into Protoparvoviruses Capsid Morphology.
PMID:32560452
Theoretical insights on helix repacking as the origin of P-glycoprotein promiscuity.
PMID:32555203
Linking Biochemical and Structural States of SERCA: Achievements, Challenges, and New Opportunities.
PMID:32532023
ELA/APELA precursor cleaved by furin displays tumor suppressor function in renal cell carcinoma through mTORC1 activation.
PMID:32516140
A substitution in cGMP-dependent protein kinase 1 associated with aortic disease induces an active conformation in the absence of cGMP.
PMID:32506052
Attenuation of Heparan Sulfate Proteoglycan Binding Enhances In Vivo Transduction of Human Primary Hepatocytes with AAV2.
PMID:32490035
Enzymatic and Mutational Analysis of the PruA Pteridine Reductase Required for Pterin-Dependent Control of Biofilm Formation in Agrobacterium tumefaciens.
PMID:32482721
Electromechanical coupling in the hyperpolarization-activated K+ channel KAT1.
PMID:32461693
Application of the Brown dynamics fluctuation-dissipation theorem to the study of Plasmodium berghei transporter protein PbAQP.
PMID:32457897
Combining data integration and molecular dynamics for target identification in α-Synuclein-aggregating neurodegenerative diseases: Structural insights on Synaptojanin-1 (Synj1).
PMID:32419904
ABC Transporter DerAB of Lactobacillus casei Mediates Resistance against Insect-Derived Defensins.
PMID:32414796
Structural and Functional Analysis of Gly212 Mutants Reveals the Importance of Intersubunit Interactions in ASIC1a Channel Function.
PMID:32411719
Protection against a chlamydial respiratory challenge by a chimeric vaccine formulated with the Chlamydia muridarum major outer membrane protein variable domains using the Neisseria lactamica porin B as a scaffold.
PMID:32411400
A trimodular bacterial enzyme combining hydrolytic activity with oxidative glycosidic bond cleavage efficiently degrades chitin.
PMID:32398257
A protein palmitoylation cascade regulates microtubule cytoskeleton integrity in Plasmodium.
PMID:32395856
Identification and functional characterization of a hemizygous novel intronic variant in OCRL gene causes Lowe syndrome.
PMID:32394213
Pharmacologic TWIK-Related Acid-Sensitive K+ Channel (TASK-1) Potassium Channel Inhibitor A293 Facilitates Acute Cardioversion of Paroxysmal Atrial Fibrillation in a Porcine Large Animal Model.
PMID:32390491
Adaptations of Escherichia coli strains to oxidative stress are reflected in properties of their structural proteomes.
PMID:32349661
Drosophila as a model for studying cystic fibrosis pathophysiology of the gastrointestinal system.
PMID:32345720
Natural products may interfere with SARS-CoV-2 attachment to the host cell.
PMID:32340551
SARS-CoV-2 RNA dependent RNA polymerase (RdRp) targeting: an in silico perspective.
PMID:32338164
Different effects of carbohydrate binding modules on the viscoelasticity of nanocellulose gels.
PMID:32337376
Mutational Analysis of the Putative Anti-Müllerian Hormone (AMH) Binding Interface on its Type II Receptor, AMHR2.
PMID:32333774
Déjà vu: Stimulating open drug discovery for SARS-CoV-2.
PMID:32320852
Copper/Zinc Superoxide Dismutase from the Crocodile Icefish Chionodraco hamatus: Antioxidant Defense at Constant Sub-Zero Temperature.
PMID:32316382
Comparative Molecular Dynamics Simulations Provide Insight Into Antibiotic Interactions: A Case Study Using the Enzyme L,L-Diaminopimelate Aminotransferase (DapL).
PMID:32274387
Structural Insights into the Mammalian Late-Stage Initiation Complexes.
PMID:32268096
Dissecting the Interaction Deficiency of a Cartilaginous Fish Digestive Lipase with Pancreatic Colipase: Biochemical and Structural Insights.
PMID:32258111
Monomeric NADH-Oxidizing Methylenetetrahydrofolate Reductases from Mycobacterium smegmatis Lack Flavin Coenzyme.
PMID:32253341
Genome sequencing of Rigidoporus microporus provides insights on genes important for wood decay, latex tolerance and interspecific fungal interactions.
PMID:32251355
Computational Study on the Effect of Inactivating/Activating Mutations on the Inhibition of MEK1 by Trametinib.
PMID:32245216
Structural and Functional Analysis of PGRP-LC Indicates Exclusive Dap-Type PGN Binding in Bumblebees.
PMID:32244587
Frontiers in biomolecular mesh generation and molecular visualization systems.
PMID:32240387
Computational Inference of Selection Underlying the Evolution of the Novel Coronavirus, Severe Acute Respiratory Syndrome Coronavirus 2.
PMID:32238584
Ribavirin, Remdesivir, Sofosbuvir, Galidesivir, and Tenofovir against SARS-CoV-2 RNA dependent RNA polymerase (RdRp): A molecular docking study.
PMID:32222463
Insights into Interactions of Flavanones with Target Human Respiratory Syncytial Virus M2-1 Protein from STD-NMR, Fluorescence Spectroscopy, and Computational Simulations.
PMID:32213871
Comprehensive Computational Analysis of Protein Phenotype Changes Due to Plausible Deleterious Variants of Human SPTLC1 Gene.
PMID:32195206
The Atypical Protein Kinase C Small Molecule Inhibitor ζ-Stat, and Its Effects on Invasion Through Decreases in PKC-ζ Protein Expression.
PMID:32175276
COVID-19 spike-host cell receptor GRP78 binding site prediction.
PMID:32169481
Probing the Transition State in Enzyme Catalysis by High-Pressure NMR Dynamics.
PMID:32159076
Comparative genomics analysis of c-di-GMP metabolism and regulation in Microcystis aeruginosa.
PMID:32151246
Identification of a Pivotal Residue for Determining the Block Structure-Forming Properties of Alginate C-5 Epimerases.
PMID:32149266
Structural and biochemical characterization of mitochondrial citrate synthase 4 from Arabidopsis thaliana.
PMID:32133996
Anti-HCV, nucleotide inhibitors, repurposing against COVID-19.
PMID:32119961
A Taxicab geometry quantification system to evaluate the performance of in silico methods: a case study on adenosine receptors ligands.
PMID:32112287
Development of a DUB-selective fluorogenic substrate.
PMID:32110315
Pre-arrayed Pan-AAV Peptide Display Libraries for Rapid Single-Round Screening.
PMID:32105604
Enterovirus 71 Infection Shapes Host T Cell Receptor Repertoire and Presumably Expands VP1-Specific TCRβ CDR3 Cluster.
PMID:32075096
Modulation of Symbiotic Compatibility by Rhizobial Zinc Starvation Machinery.
PMID:32071267
Engineering Herbicide-Tolerance Rice Expressing an Acetohydroxyacid Synthase with a Single Amino Acid Deletion.
PMID:32070060
Alanine Substitution Inactivates Cross-Reacting Epitopes in Dengue Virus Recombinant Envelope Proteins.
PMID:32069839
Structural basis of keto acid utilization in nonribosomal depsipeptide synthesis.
PMID:32066969
Dibenzofuranylethylamines as 5-HT2A/2C Receptor Agonists.
PMID:32064387
Elongation Factor Tu Switch I Element is a Gate for Aminoacyl-tRNA Selection.
PMID:32061931
Bioinformatics design and experimental validation of influenza A virus multi-epitopes that induce neutralizing antibodies.
PMID:32060794
A SNP of bacterial blc disturbs gut lysophospholipid homeostasis and induces inflammation through epithelial barrier disruption.
PMID:32058942
Epidemic and genetic characterization of porcine epidemic diarrhea virus strains circulating in the regions around Hunan, China, during 2017-2018.
PMID:32056002
Characterization of the Goose CAPN3 Gene and its Expression Pattern in Muscle Tissues of Sichuan White Geese at Different Growth Stages.
PMID:32055171
High-throughput quantification of protein structural change reveals potential mechanisms of temperature adaptation in Mytilus mussels.
PMID:32054457
An ENU-induced mutation in Twist1 transactivation domain causes hindlimb polydactyly with complete penetrance and dominant-negatively impairs E2A-dependent transcription.
PMID:32051525
Characterizing lineage-specific evolution and the processes driving genomic diversification in chordates.
PMID:32046633
Novel Immunomodulatory Proteins Generated via Directed Evolution of Variant IgSF Domains.
PMID:32038630
Identification and Comparative Analysis of Venom Proteins in a Pupal Ectoparasitoid, Pachycrepoideus vindemmiae.
PMID:32038312
Transient States and Barriers from Molecular Simulations and the Milestoning Theory: Kinetics in Ligand-Protein Recognition and Compound Design.
PMID:32031801
Phylogeography of Kyasanur Forest Disease virus in India (1957-2017) reveals evolution and spread in the Western Ghats region.
PMID:32029759
Analysis of a Therapeutic Antibody Cocktail Reveals Determinants for Cooperative and Broad Ebolavirus Neutralization.
PMID:32023489
A Genetic Toggle for Chemical Control of Individual Plk1 Substrates.
PMID:32017920
Unique subsite specificity and potential natural function of a chitosan deacetylase from the human pathogen Cryptococcus neoformans.
PMID:32015121
Integrated Computational Approaches and Tools forAllosteric Drug Discovery.
PMID:32013012
MINI SEED 2 (MIS2) Encodes a Receptor-like Kinase that Controls Grain Size and Shape in Rice.
PMID:32006119
Understanding and Controlling Food Protein Structure and Function in Foods: Perspectives from Experiments and Computer Simulations.
PMID:31951485
The topology of the ER-resident phospholipid methyltransferase Opi3 of Saccharomyces cerevisiae is consistent with in trans catalysis.
PMID:31932304
Functional Characterization of a Venom Protein Calreticulin in the Ectoparasitoid Pachycrepoideus vindemiae.
PMID:31906042
Substrate specificity of thioredoxins and glutaredoxins - towards a functional classification.
PMID:31890941
Finding small molecules with pan-serotype activity to target Dengue non-structural protein 1.
PMID:31890750
Defining the function of SUMO system in pod development and abiotic stresses in Peanut.
PMID:31884953
Uncovering the functional residues of Arabidopsis isoprenoid biosynthesis enzyme HDS.
PMID:31879352
The Mitochondrial Small Heat Shock Protein HSP22 from Pea is a Thermosoluble Chaperone Prone to Co-Precipitate with Unfolding Client Proteins.
PMID:31877784
Computational Modeling Explains the Multi Sterol Ligand Specificity of the N-Terminal Domain of Niemann-Pick C1-Like 1 Protein.
PMID:31867479
Divalent cations promote TALE DNA-binding specificity.
PMID:31863586
A prospective compound screening contest identified broader inhibitors for Sirtuin 1.
PMID:31863054
Structure comparison of the chimeric AAV2.7m8 vector with parental AAV2.
PMID:31859208
The zebrafish NLRP3 inflammasome has functional roles in ASC-dependent interleukin-1β maturation and gasdermin E-mediated pyroptosis.
PMID:31852739
Toward the Accuracy and Speed of Protein Side-Chain Packing: A Systematic Study on Rotamer Libraries.
PMID:31851497
Involvement of Exogenous N-Acyl-Homoserine Lactones in Spoilage Potential of Pseudomonas fluorescens Isolated From Refrigerated Turbot.
PMID:31849873
Incorporation of Agouti-Related Protein (AgRP) Human Single Nucleotide Polymorphisms (SNPs) in the AgRP-Derived Macrocyclic Scaffold c[Pro-Arg-Phe-Phe-Asn-Ala-Phe-dPro] Decreases Melanocortin-4 Receptor Antagonist Potency and Results in the Discovery of Melanocortin-5 Receptor Antagonists.
PMID:31845801
Identification and validation of specific B-cell epitopes of hantaviruses associated to hemorrhagic fever and renal syndrome.
PMID:31841521
Antiquorum sensing and antibiofilm potential of biosynthesized silver nanoparticles of Myristica fragrans seed extract against MDR Salmonella enterica serovar Typhi isolates from asymptomatic typhoid carriers and typhoid patients.
PMID:31836973
Localization and enzyme kinetics of aminopeptidase N3 from Toxoplasma gondii.
PMID:31836922
Structural insights into the mechanism of c-di-GMP-bound YcgR regulating flagellar motility in Escherichia coli.
PMID:31836667
Comparative Analysis of the Capsid Structures of AAVrh.10, AAVrh.39, and AAV8.
PMID:31826994
Integrative Multi-Kinase Approach for the Identification of Potent Antiplasmodial Hits.
PMID:31824917
Docking analysis of models for 4-hydroxy-3-methylbut-2-enyl diphosphate reductase and a ferredoxin from Botryococcus braunii, race B.
PMID:31819737
The Molecular Mechanism of Ginsenoside Analogs Activating TMEM16A.
PMID:31818463
Effects of Synergistic Inhibition on α-glucosidase by Phytoalexins in Soybeans.
PMID:31817312
Clinical utility of targeted gene enrichment and sequencing technique in the diagnosis of adult hereditary spherocytosis.
PMID:31807509
Mechanistic basis of the inhibition of SLC11/NRAMP-mediated metal ion transport by bis-isothiourea substituted compounds.
PMID:31804182
Multiple selective sweeps of ancient polymorphisms in and around LTα located in the MHC class III region on chromosome 6.
PMID:31791241
A molecular epidemiological investigation of PEDV in China: Characterization of co-infection and genetic diversity of S1-based genes.
PMID:31785090
HKPocket: human kinase pocket database for drug design.
PMID:31783725
Influenza H1 Mosaic Hemagglutinin Vaccine Induces Broad Immunity and Protection in Mice.
PMID:31771231
In situ structure determination at nanometer resolution using TYGRESS.
PMID:31768058
Actinomyces Produces Defensin-Like Bacteriocins (Actifensins) with a Highly Degenerate Structure and Broad Antimicrobial Activity.
PMID:31767775
A Novel SLC1A4 Mutation (p.Y191*) Causes Spastic Tetraplegia, Thin Corpus Callosum, and Progressive Microcephaly (SPATCCM) With Seizure Disorder.
PMID:31763347
Bioinformatics analysis of ubiquitin expression protein gene from Heterodera latipons.
PMID:31762610
Characterization of Single Amino Acid Variations in an EDTA-Tolerating Non-specific Nuclease from the Ice-Nucleating Bacterium Pseudomonas syringae.
PMID:31749083
Identification of lipid A deacylase as a novel, highly conserved and protective antigen against enterohemorrhagic Escherichia coli.
PMID:31745113
Genome-Wide Identification and Characterization of FBA Gene Family in Polyploid Crop Brassica napus.
PMID:31731804
Adaptive Laboratory Evolution of Cupriavidus necator H16 for Carbon Co-Utilization with Glycerol.
PMID:31731699
Characterization of two thermophilic cellulases from Talaromyces leycettanus JCM12802 and their synergistic action on cellulose hydrolysis.
PMID:31730665
Designing a less immunogenic nattokinase from Bacillus subtilis subsp. natto: a computational mutagenesis.
PMID:31705312
Exfoliative toxin E, a new Staphylococcus aureus virulence factor with host-specific activity.
PMID:31704997
Extracellular production of the engineered thermostable protease pernisine from Aeropyrum pernix K1 in Streptomyces rimosus.
PMID:31699090
β-Xylosidases: Structural Diversity, Catalytic Mechanism, and Inhibition by Monosaccharides.
PMID:31698702
Genome-wide analysis, transcription factor network approach and gene expression profile of GH3 genes over early somatic embryogenesis in Coffea spp.
PMID:31694532
Curcumin Blocks Cytotoxicity of Enteroaggregative and Enteropathogenic Escherichia coli by Blocking Pet and EspC Proteolytic Release From Bacterial Outer Membrane.
PMID:31681620
Monitoring Silent Spillovers Before Emergence: A Pilot Study at the Tick/Human Interface in Thailand.
PMID:31681195
ACE gene missense mutation in a case with early-onset, rapid progressing dementia.
PMID:31673674
A large intragenic deletion in the CLCN1 gene causes Hereditary Myotonia in pigs.
PMID:31666547
Identification of linear epitopes in SjSP-13 of Schistosoma japonicum using a GST-peptide fusion protein microplate array.
PMID:31666115
How oncogenic mutations activate human MAP kinase 1 (MEK1): a molecular dynamics simulation study.
PMID:31658877
Simulation of Gating Currents of the Shaker K Channel Using a Brownian Model of the Voltage Sensor.
PMID:31653450
A Novel Pathogenic Variant in NAGLU (N-Acetyl-Alpha-Glucosaminidase) gene Identified by Targeted Next-Generation Sequencing Followed by in Silico Analysis.
PMID:31645877
Exceptionally high rates of positive selection on the rbcL gene in the genus Ilex (Aquifoliaceae).
PMID:31638910
Biochemical and physiological flexibility accompanies reduced cellulose biosynthesis in Brachypodium cesa1 S830N.
PMID:31636881
Conformational flexibility of fork-remodeling helicase Rad5 shown by full-ensemble hybrid methods.
PMID:31626633
Differential mechanisms of tolerance to extreme environmental conditions in tardigrades.
PMID:31624306
A docking-based structural analysis of geldanamycin-derived inhibitor binding to human or Leishmania Hsp90.
PMID:31611575
MotifAnalyzer-PDZ: A computational program to investigate the evolution of PDZ-binding target specificity.
PMID:31599029
Effects of the substituted amino acid residues on the thermal properties of monomeric isocitrate dehydrogenases from a psychrophilic bacterium, Psychromonas marina, and a mesophilic bacterium, Azotobacter vinelandii.
PMID:31595369
Cryo-EM structure of the ClpXP protein degradation machinery.
PMID:31582852
Generation and Characterization of Induced Pluripotent Stem Cells and Retinal Organoids From a Leber's Congenital Amaurosis Patient With Novel RPE65 Mutations.
PMID:31572124
Chalcones as a basis for computer-aided drug design: innovative approaches to tackle malaria.
PMID:31556721
Structural determinants underlying permeant discrimination of the Cx43 hemichannel.
PMID:31554662
Crowder-Induced Conformational Ensemble Shift in Escherichia coli Prolyl-tRNA Synthetase.
PMID:31542226
A processive endoglucanase with multi-substrate specificity is characterized from porcine gut microbiota.
PMID:31541154
Characterization of Novel Fragment Antibodies Against TNF-alpha Isolated Using Phage Display Technique.
PMID:31531059
Protamines from liverwort are produced by post-translational cleavage and C-terminal di-aminopropanelation of several male germ-specific H1 histones.
PMID:31527083
HH-suite3 for fast remote homology detection and deep protein annotation.
PMID:31521110
In Vivo Expression of NUP93 and Its Alteration by NUP93 Mutations Causing Focal Segmental Glomerulosclerosis.
PMID:31517150
Effect of piceatannol-rich passion fruit seed extract on human glyoxalase I-mediated cancer cell growth.
PMID:31517069
Synthesis, Antimicrobial Screening, Homology Modeling, and Molecular Docking Studies of a New Series of Schiff Base Derivatives as Prospective Fungal Inhibitor Candidates.
PMID:31500095
Leishmania mexicana Trypanothione Reductase Inhibitors: Computational and Biological Studies.
PMID:31487860
Protein model accuracy estimation based on local structure quality assessment using 3D convolutional neural network.
PMID:31487288
Enhancement of the Anti-Aggregation Activity of a Molecular Chaperone Using a Rationally Designed Post-Translational Modification.
PMID:31482124
Systematic Meta-Analysis Identifies Co-Expressed Kinases and GPCRs in Ovarian Cancer Tissues Revealing a Potential for Targeted Kinase Inhibitor Delivery.
PMID:31480803
Interplay between Affinity and Valency in Effector Cell Degranulation: A Model System with Polcalcin Allergens and Human Patient-Derived IgE Antibodies.
PMID:31462504
In Silico Structural Modeling and Analysis of Elongation Factor-1 Alpha and Elongation Factor-like Protein.
PMID:31459830
Computational Study of the Loss-of-Function Mutations in the Kv1.5 Channel Associated with Atrial Fibrillation.
PMID:31459020
Rose Bengal Binding to Collagen and Tissue Photobonding.
PMID:31457260
Positive selection in dNTPase SAMHD1 throughout mammalian evolution.
PMID:31451672
Polymerase δ deficiency causes syndromic immunodeficiency with replicative stress.
PMID:31449058
Neuroprotective effects of melatonin and celecoxib against ethanol-induced neurodegeneration: a computational and pharmacological approach.
PMID:31447548
Properties of a Non-canonical Complex Formed Between a Tepary Bean (Phaseolus acutifolius) Protease Inhibitor and α-Chymotrypsin.
PMID:31435809
Gene Expression Profiling Analysis Reveals Putative Phytochemotherapeutic Target for Castration-Resistant Prostate Cancer.
PMID:31428582
I-TASSER gateway: A protein structure and function prediction server powered by XSEDE.
PMID:31427836
KAP1 is an antiparallel dimer with a functional asymmetry.
PMID:31427381
Ammopiptanthus mongolicus stress-responsive NAC gene enhances the tolerance of transgenic Arabidopsis thaliana to drought and cold stresses.
PMID:31424071
A hypomorphic allele of SLC35D1 results in Schneckenbecken-like dysplasia.
PMID:31423530
Characterization of a bifunctional alginate lyase as a new member of the polysaccharide lyase family 17 from a marine strain BP-2.
PMID:31418101
In silico evidence of de novo interactions between ribosomal and Epstein - Barr virus proteins.
PMID:31416416
Serological Screening for Coronavirus Infections in Cats.
PMID:31412572
UDP-N-acetyl-α-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase from the snail Biomphalaria glabrata - structural reflections.
PMID:31396754
The CHD4-related syndrome: a comprehensive investigation of the clinical spectrum, genotype-phenotype correlations, and molecular basis.
PMID:31388190
Three GLI2 mutations combined potentially underlie non-syndromic cleft lip with or without cleft palate in a Chinese pedigree.
PMID:31386309
Posttranscriptional Regulation of RhBRC1 (Rosa hybrida BRANCHED1) in Response to Sugars is Mediated via its Own 3' Untranslated Region, with a Potential Role of RhPUF4 (Pumilio RNA-Binding Protein Family).
PMID:31382685
NS2B/NS3 mutations enhance the infectivity of genotype I Japanese encephalitis virus in amplifying hosts.
PMID:31381617
Defining a role for lung function associated gene GSTCD in cell homeostasis.
PMID:31370853
Structural basis for broad substrate specificity of UDP-glucose 4-epimerase in the human milk oligosaccharide catabolic pathway of Bifidobacterium longum.
PMID:31366978
A non-covalent inhibitor XMU-MP-3 overrides ibrutinib-resistant BtkC481S mutation in B-cell malignancies.
PMID:31364164
Molecular characterization and functional analysis of the Schistosoma mekongi Ca2+-dependent cysteine protease (calpain).
PMID:31362766
MAS NMR on a Red/Far-Red Photochromic Cyanobacteriochrome All2699 from Nostoc.
PMID:31357417
Differential binding affinity of tau repeat region R2 with neuronal-specific β-tubulin isotypes.
PMID:31346240
Identification of evolutionary and kinetic drivers of NAD-dependent signaling.
PMID:31341085
Cryo-EM structures and functional characterization of murine Slc26a9 reveal mechanism of uncoupled chloride transport.
PMID:31339488
Evolutionary couplings detect side-chain interactions.
PMID:31328041
Bypassing pan-enterovirus host factor PLA2G16.
PMID:31320648
Hook3 is a scaffold for the opposite-polarity microtubule-based motors cytoplasmic dynein-1 and KIF1C.
PMID:31320392
The MarR-Type Repressor MhqR Confers Quinone and Antimicrobial Resistance in Staphylococcus aureus.
PMID:31310152
Expression of different ParE toxins results in conserved phenotypes with distinguishable classes of toxicity.
PMID:31309747
Atomistic Models from Orientation and Distance Constraints Using EPR of a Bifunctional Spin Label.
PMID:31301803
Lamin A molecular compression and sliding as mechanisms behind nucleoskeleton elasticity.
PMID:31296869
Purification and characterization of Terfezia claveryi TcCAT-1, a desert truffle catalase upregulated in mycorrhizal symbiosis.
PMID:31291312
An array of basic residues is essential for the nucleolytic activity of the PHP domain of bacterial/archaeal PolX DNA polymerases.
PMID:31289311
TP53, ETV6 and RUNX1 germline variants in a case series of patients developing secondary neoplasms after treatment for childhood acute lymphoblastic leukemia.
PMID:31289210
Bacterial MbtH-like Proteins Stimulate Nonribosomal Peptide Synthetase-Derived Secondary Metabolism in Filamentous Fungi.
PMID:31284717
Isolation and functional characterization of two dioxygenases putatively involved in bixin biosynthesis in annatto (Bixa orellana L.).
PMID:31275744
A Human-Derived Monoclonal Antibody Targeting Extracellular Connexin Domain Selectively Modulates Hemichannel Function.
PMID:31263420
Difficult-to-neutralize global HIV-1 isolates are neutralized by antibodies targeting open envelope conformations.
PMID:31263112
Structural basis of TFIIH activation for nucleotide excision repair.
PMID:31253769
Enzyme activity and structural features of three single-domain phloem cyclophilins from Brassica napus.
PMID:31249367
Drug Repurposing for Paracoccidioidomycosis Through a Computational Chemogenomics Framework.
PMID:31244810
A broadly neutralizing germline-like human monoclonal antibody against dengue virus envelope domain III.
PMID:31242272
The R941L mutation in MYH14 disrupts mitochondrial fission and associates with peripheral neuropathy.
PMID:31231018
Pathogenic Autoreactive T and B Cells Cross-React with Mimotopes Expressed by a Common Human Gut Commensal to Trigger Autoimmunity.
PMID:31227334
Discovery of an intrasubunit nicotinic acetylcholine receptor-binding site for the positive allosteric modulator Br-PBTC.
PMID:31221718
Stapled EGFR peptide reduces inflammatory breast cancer and inhibits additional HER-driven models of cancer.
PMID:31215437
Identification and Functional Analysis of NLP-Encoding Genes from the Postharvest Pathogen Penicillium expansum.
PMID:31208074
Immunoglobulin light chains generate proinflammatory and profibrotic kidney injury.
PMID:31205024
A Genomic, Evolutionary, and Mechanistic Study of MCR-5 Action Suggests Functional Unification across the MCR Family of Colistin Resistance.
PMID:31179217
Semi-rational evolution of the 3-(3-hydroxyalkanoyloxy)alkanoate (HAA) synthase RhlA to improve rhamnolipid production in Pseudomonas aeruginosa and Burkholderia glumae.
PMID:31177633
Comparative genomics provides new insights into the remarkable adaptations of the African wild dog (Lycaon pictus).
PMID:31171819
Trypanosoma brucei centrin5 is enriched in the flagellum and interacts with other centrins in a calcium-dependent manner.
PMID:31161731
The enigmatic role of fungal annexins: the case of Cryptococcus neoformans.
PMID:31140968
Elucidation of the biosynthesis pathway and heterologous construction of a sustainable route for producing umbelliferone.
PMID:31139252
Metabolomics Studies To Decipher Stress Responses in Mycobacterium smegmatis Point to a Putative Pathway of Methylated Amine Biosynthesis.
PMID:31138627
Novel Fluorescent Cyclic Nucleotide Derivatives to Study CNG and HCN Channel Function.
PMID:31130235
In silico and in vitro studies of lupeol and iso-orientin as potential antidiabetic agents in a rat model.
PMID:31123393
Default Activation and Nuclear Translocation of the Plant Cellular Energy Sensor SnRK1 Regulate Metabolic Stress Responses and Development.
PMID:31123051
Structure-based inhibitory peptide design targeting peptide-substrate binding site in EGFR tyrosine kinase.
PMID:31116768
Identification and first characterization of DinJ-YafQ toxin-antitoxin systems in Lactobacillus species of biotechnological interest.
PMID:31114007
Investigating function roles of hypothetical proteins encoded by the Mycobacterium tuberculosis H37Rv genome.
PMID:31113361
Specific Binding Peptides from Rv3632: A Strategy for Blocking Mycobacterium tuberculosis Entry to Target Cells?
PMID:31111070
Functional specialization of UDP-glycosyltransferase 73P12 in licorice to produce a sweet triterpenoid saponin, glycyrrhizin.
PMID:31095780
Truncating variant burden in high-functioning autism and pleiotropic effects of LRP1 across psychiatric phenotypes.
PMID:31094488
Characterization of a class III peroxidase from Artemisia annua: relevance to artemisinin metabolism and beyond.
PMID:31093899
Closing the gap: yeast electron-transferring flavoprotein links the oxidation of d-lactate and d-α-hydroxyglutarate to energy production via the respiratory chain.
PMID:31081204
A Unique Presentation of Infantile-Onset Colitis and Eosinophilic Disease without Recurrent Infections Resulting from a Novel Homozygous CARMIL2 Variant.
PMID:31079270
Modeling Conformationally Flexible Proteins With X-ray Scattering and Molecular Simulations.
PMID:31073392
Early screening the small bowel is key to protect Peutz-Jeghers syndrome patients from surgery: a novel mutation c.243delG in STK11 gene.
PMID:31072341
Familial Immune Thrombocytopenia Associated With a Novel Variant in IKZF1.
PMID:31069201
In silico ADME and Toxicity Prediction of Ceftazidime and Its Impurities.
PMID:31068821
A predicted plastid rhomboid protease affects phosphatidic acid metabolism in Arabidopsis thaliana.
PMID:31062431
A 25-Residue Peptide From Botrytis cinerea Xylanase BcXyn11A Elicits Plant Defenses.
PMID:31057580
The Early Asexual Development Regulator fluG Codes for a Putative Bifunctional Enzyme.
PMID:31057506
PMS2 germline mutation c.943C>T (p.Arg315*)-induced Lynch syndrome-associated ovarian cancer.
PMID:31056861
De Novo Duplication in the CHD7 Gene Associated With Severe CHARGE Syndrome.
PMID:31043788
IFIT5 Participates in the Antiviral Mechanisms of Rainbow Trout Red Blood Cells.
PMID:31040842
Modeling of Protein⁻Protein Interactions in Cytokinin Signal Transduction.
PMID:31035389
Cryo-EM structures of the pore-forming A subunit from the Yersinia entomophaga ABC toxin.
PMID:31028251
Deciphering the three-domain architecture in schlafens and the structures and roles of human schlafen12 and serpinB12 in transcriptional regulation.
PMID:31026779
Opsin 1 and Opsin 2 of the Corn Smut Fungus Ustilago maydis Are Green Light-Driven Proton Pumps.
PMID:31024506
Identification and Signature Sequences of Bacterial Δ4,5Hexuronate-2-O-Sulfatases.
PMID:31024490
Evidence for relaxed selection of mitogenome in rapid-flow cyprinids.
PMID:31016677
SIRT6 Is Responsible for More Efficient DNA Double-Strand Break Repair in Long-Lived Species.
PMID:31002797
Characterization of putative proteins encoded by variable ORFs in white spot syndrome virus genome.
PMID:30999895
In silico analysis of the V66M variant of human BDNF in psychiatric disorders: An approach to precision medicine.
PMID:30998730
Interaction of carbohydrate-binding modules with poly(ethylene terephthalate).
PMID:30993383
Coenzyme Q biosynthesis in the biopesticide Shenqinmycin-producing Pseudomonas aeruginosa strain M18.
PMID:30989356
A pan-coronavirus fusion inhibitor targeting the HR1 domain of human coronavirus spike.
PMID:30989115
A photoswitchable GABA receptor channel blocker.
PMID:30981211
In-silico analysis of novel p.(Gly14Ser) variant of ATOX1 gene: plausible role in modulating ATOX1-ATP7B interaction.
PMID:30980273
Architecture and subunit arrangement of native AMPA receptors elucidated by cryo-EM.
PMID:30975770
Analysis of the coding sequences of clownfish reveals molecular convergence in the evolution of lifespan.
PMID:30975078
Structural basis for auxiliary subunit KCTD16 regulation of the GABAB receptor.
PMID:30971491
Impact of antibiotic treatment and host innate immune pressure on enterococcal adaptation in the human bloodstream.
PMID:30971455
N-glycosylation-dependent regulation of hK2P17.1 currents.
PMID:30969900
Using the Predicted Structure of the Amot Coiled Coil Homology Domain to Understand Lipid Binding.
PMID:30957019
A unique dynamin-related protein is essential for mitochondrial fission in Toxoplasma gondii.
PMID:30947298
In vivo recombination of Saccharomyces eubayanus maltose-transporter genes yields a chimeric transporter that enables maltotriose fermentation.
PMID:30946741
Antioxidant activity and antibacterial evaluation of new thiazolin-4-one derivatives as potential tryptophanyl-tRNA synthetase inhibitors.
PMID:30938216
Rational protein design of Bacillus sp. MN chitosanase for altered substrate binding and production of specific chitosan oligomers.
PMID:30918529
Detection and characterization of an albumin-like protein in Leishmania donovani.
PMID:30903348
A novel TUFM homozygous variant in a child with mitochondrial cardiomyopathy expands the phenotype of combined oxidative phosphorylation deficiency 4.
PMID:30903008
Histone deacetylase enzymes as potential drug targets of Neglected Tropical Diseases caused by cestodes.
PMID:30897528
First Betalain-Producing Bacteria Break the Exclusive Presence of the Pigments in the Plant Kingdom.
PMID:30890610
Crystallographic Structures of IlvN·Val/Ile Complexes: Conformational Selectivity for Feedback Inhibition of Aceto Hydroxy Acid Synthases.
PMID:30887800
The proton pumping bo oxidase from Vitreoscilla.
PMID:30886219
From uncertainty to pathogenicity: clinical and functional interrogation of a rare TP53 in-frame deletion.
PMID:30886117
DPH1 syndrome: two novel variants and structural and functional analyses of seven missense variants identified in syndromic patients.
PMID:30877278
In Silico Analysis of Homologous Heterodimers of Cruzipain-Chagasin from Structural Models Built by Homology.
PMID:30875920
Host adaptation and convergent evolution increases antibiotic resistance without loss of virulence in a major human pathogen.
PMID:30875398
Meta-analysis suggests evidence of novel stress-related pathway components in Orsay virus - Caenorhabditis elegans viral model.
PMID:30867481
A study of CCD8 genes/proteins in seven monocots and eight dicots.
PMID:30861026
Decline of transmissible gastroenteritis virus and its complex evolutionary relationship with porcine respiratory coronavirus in the United States.
PMID:30850666
Validation and Stabilization of a Prophage Lysin of Clostridium perfringens by Using Yeast Surface Display and Coevolutionary Models.
PMID:30850429
Novel mutation in the MED23 gene for intellectual disability: A case report and literature review.
PMID:30847200
Pectinase secreted by psychrotolerant fungi: identification, molecular characterization and heterologous expression of a cold-active polygalacturonase from Tetracladium sp.
PMID:30845994
Structural organization and functional divergence of high isoelectric point α-amylase genes in bread wheat (Triticum aestivum L.) and barley (Hordeum vulgare L.).
PMID:30845909
Insights into the dynamic nature of the dsRNA-bound TLR3 complex.
PMID:30842554
Identification of a novel potassium channel (GiK) as a potential drug target in Giardia lamblia: Computational descriptions of binding sites.
PMID:30834181
Darolutamide is a potent androgen receptor antagonist with strong efficacy in prostate cancer models.
PMID:30828788
Temperature adaptation of DNA ligases from psychrophilic organisms.
PMID:30826937
3D structure prediction of VAPC1 and identification of dual natural inhibitors for VPAC1 and EGFR.
PMID:30810849
Molecular characterization and homology modeling of liver X receptor in Asian seabass, Lates calcarifer: predicted functions in reproduction and lipid metabolism.
PMID:30806874
Naja atra venom peptide reduces pain by selectively blocking the voltage-gated sodium channel Nav1.8.
PMID:30804211
Structural introspection of a putative fluoride transporter in plants.
PMID:30800614
A sequestered fusion peptide in the structure of an HIV-1 transmitted founder envelope trimer.
PMID:30787293
Deciphering structure, function and mechanism of Plasmodium IspD homologs from their evolutionary imprints.
PMID:30783866
Protease-Activatable Adeno-Associated Virus Vector for Gene Delivery to Damaged Heart Tissue.
PMID:30772143
A polyextremophilic alcohol dehydrogenase from the Atlantis II Deep Red Sea brine pool.
PMID:30761247
Small Molecule Docking of DNA Repair Proteins Associated with Cancer Survival Following PCNA Metagene Adjustment: A Potential Novel Class of Repair Inhibitors.
PMID:30759820
Microtubule plus-ends act as physical signaling hubs to activate RhoA during cytokinesis.
PMID:30758285
Increased drug permeability of a stiffened mycobacterial outer membrane in cells lacking MFS transporter Rv1410 and lipoprotein LprG.
PMID:30742339
Chaperone activation and client binding of a 2-cysteine peroxiredoxin.
PMID:30737390
In silico characterization of multiple genes encoding the GP63 virulence protein from Leishmania braziliensis: identification of sources of variation and putative roles in immune evasion.
PMID:30732584
Solution Conformation of Bovine Leukemia Virus Gag Suggests an Elongated Structure.
PMID:30731090
Myxococcus xanthus truncated globin HbO: in silico analysis and functional characterization.
PMID:30729391
Plasmodium falciparum specific helicase 2 is a dual, bipolar helicase and is crucial for parasite growth.
PMID:30728406
The expression of a tubby-like protein from Malus domestica (MdTLP7) enhances abiotic stress tolerance in Arabidopsis.
PMID:30727953
Discovery of novel dual-active 3-(4-(dimethylamino)phenyl)-7-aminoalcoxy-coumarin as potent and selective acetylcholinesterase inhibitor and antioxidant.
PMID:30727776
Interaction between Cellobiose Dehydrogenase and Lytic Polysaccharide Monooxygenase.
PMID:30715860
Genome-wide identification and expression analysis of expansin gene family in common wheat (Triticum aestivum L.).
PMID:30709338
Structural and Phylogenetic Diversity of Anaerobic Carbon-Monoxide Dehydrogenases.
PMID:30705673
Action and mechanism of the colistin resistance enzyme MCR-4.
PMID:30701201
Plant organellar DNA polymerases repair double-stranded breaks by microhomology-mediated end-joining.
PMID:30698803
The Amphibian Diacylglycerol O-acyltransferase 2 (DGAT2): a 'paleo-protein' with Conserved Function but Unique Folding.
PMID:30697667
Lateral distribution of phosphatidylinositol 4,5-bisphosphate in membranes regulates formin- and ARP2/3-mediated actin nucleation.
PMID:30692198
Stability of cytochromes c' from psychrophilic and piezophilic Shewanella species: implications for complex multiple adaptation to low temperature and high hydrostatic pressure.
PMID:30689055
Loss-of-function mutations in QRICH2 cause male infertility with multiple morphological abnormalities of the sperm flagella.
PMID:30683861
Spectrum of neurodevelopmental disease associated with the GNAO1 guanosine triphosphate-binding region.
PMID:30682224
Asp305Gly mutation improved the activity and stability of the styrene monooxygenase for efficient epoxide production in Pseudomonas putida KT2440.
PMID:30678678
Genetic evolution analysis and pathogenicity assessment of porcine epidemic diarrhea virus strains circulating in part of China during 2011-2017.
PMID:30677534
Single-channel permeability and glycerol affinity of human aquaglyceroporin AQP3.
PMID:30659792
Identification of selective inhibitors of Helicobacter pylori IMPDH as a targeted therapy for the infection.
PMID:30655593
Hydroxycholesterol binds and enhances the anti-viral activities of zebrafish monomeric c-reactive protein isoforms.
PMID:30653529
Chaperone-mediated secretion switching from early to middle substrates in the type III secretion system encoded by Salmonella pathogenicity island 2.
PMID:30651351
An in silico structural, functional and phylogenetic analysis with three dimensional protein modeling of alkaline phosphatase enzyme of Pseudomonas aeruginosa.
PMID:30647696
Toward fully exploiting the therapeutic potential of marketed pharmaceuticals: the use of octreotide and chloroquine in oncology.
PMID:30643430
Acetylation of CCAR2 Establishes a BET/BRD9 Acetyl Switch in Response to Combined Deacetylase and Bromodomain Inhibition.
PMID:30643017
ClyJ Is a Novel Pneumococcal Chimeric Lysin with a Cysteine- and Histidine-Dependent Amidohydrolase/Peptidase Catalytic Domain.
PMID:30642930
Discovery of a Thermostable GH10 Xylanase with Broad Substrate Specificity from the Arctic Mid-Ocean Ridge Vent System.
PMID:30635385
Identification of a Novel Elastin-Degrading Enzyme from the Fish Pathogen Flavobacterium psychrophilum.
PMID:30635380
Structure of the SLy1 SAM homodimer reveals a new interface for SAM domain self-association.
PMID:30631134
The (R)-enantiomer of the 6-chromanol derivate SUL-121 improves renal graft perfusion via antagonism of the α1-adrenoceptor.
PMID:30626882
Cluster expansion of apolipoprotein D (ApoD) genes in teleost fishes.
PMID:30621595
Identification of Proteins Differentially Expressed in the Striatum by Melatonin in a Middle Cerebral Artery Occlusion Rat Model-a Proteomic and in silico Approach.
PMID:30618542
Sequence analysis and confirmation of the type IV pili-associated proteins PilY1, PilW and PilV in Acidithiobacillus thiooxidans.
PMID:30615628
Potent Antimalarial 2-Pyrazolyl Quinolone bc 1 (Qi) Inhibitors with Improved Drug-like Properties.
PMID:30613327
Discovery of novel geranylgeranyl reductases and characterization of their substrate promiscuity.
PMID:30607175
TGF-β2 uses the concave surface of its extended finger region to bind betaglycan's ZP domain via three residues specific to TGF-β and inhibin-α.
PMID:30598510
ABCF ATPases Involved in Protein Synthesis, Ribosome Assembly and Antibiotic Resistance: Structural and Functional Diversification across the Tree of Life.
PMID:30597160
De novo transcriptome analyses provide insights into opsin-based photoreception in the lanternshark Etmopterus spinax.
PMID:30596723
Transcriptome Comparison Reveals Distinct Selection Patterns in Domesticated and Wild Agave Species, the Important CAM Plants.
PMID:30596084
Thermococcus Eurythermalis Endonuclease IV Can Cleave Various Apurinic/Apyrimidinic Site Analogues in ssDNA and dsDNA.
PMID:30586940
Mechanisms of opening and closing of the bacterial replicative helicase.
PMID:30582519
Functional divergence of annotated l-isoaspartate O-methyltransferases in an α-proteobacterium.
PMID:30578298
The catalytic mechanism of electron-bifurcating electron transfer flavoproteins (ETFs) involves an intermediary complex with NAD<sup/>
PMID:30567738
Genome Mining of Plant NPFs Reveals Varying Conservation of Signature Motifs Associated With the Mechanism of Transport.
PMID:30564251
Mosquito Bite-Induced Controlled Human Malaria Infection with Plasmodium vivax or P. falciparum Generates Immune Responses to Homologous and Heterologous Preerythrocytic and Erythrocytic Antigens.
PMID:30559218
Mechanism of Tetramer Dissociation, Unfolding, and Oligomer Assembly of Pneumovirus M2-1 Transcription Antiterminators.
PMID:30555987
Brettanomyces bruxellensis SSU1 Haplotypes Confer Different Levels of Sulfite Tolerance When Expressed in a Saccharomyces cerevisiae SSU1 Null Mutant.
PMID:30552183
Molecular Mechanisms of Bacterial Bioluminescence.
PMID:30546856
Genome-wide identification and characterization of gene family for RWP-RK transcription factors in wheat (Triticum aestivum L.).
PMID:30540790
Cancer stem-like properties and gefitinib resistance are dependent on purine synthetic metabolism mediated by the mitochondrial enzyme MTHFD2.
PMID:30532069
NFKB1 and MANBA Confer Disease Susceptibility to Primary Biliary Cholangitis via Independent Putative Primary Functional Variants.
PMID:30528300
Molecular basis for the increased affinity of an RNA recognition motif with re-engineered specificity: A molecular dynamics and enhanced sampling simulations study.
PMID:30521520
Cellulose-specific Type B carbohydrate binding modules: understanding oligomeric and non-crystalline substrate recognition mechanisms.
PMID:30519283
Characterization and functionality of two members of the SPFH protein superfamily, prohibitin 1 and 2 in Leishmania major.
PMID:30514373
The Challenges of Analysing Highly Diverse Picobirnavirus Sequence Data.
PMID:30513931
CC2D1B Coordinates ESCRT-III Activity during the Mitotic Reformation of the Nuclear Envelope.
PMID:30513301
Giant tortoise genomes provide insights into longevity and age-related disease.
PMID:30510174
A strategy to identify a ketoreductase that preferentially synthesizes pharmaceutically relevant (S)-alcohols using whole-cell biotransformation.
PMID:30509260
The Chaperone and Redox Properties of CnoX Chaperedoxins Are Tailored to the Proteostatic Needs of Bacterial Species.
PMID:30482828
Integration of phylogenomics and molecular modeling reveals lineage-specific diversification of toxins in scorpions.
PMID:30479892
Architecture and subunit arrangement of the complete Saccharomyces cerevisiae COMPASS complex.
PMID:30479350
ONECUT2 is a targetable master regulator of lethal prostate cancer that suppresses the androgen axis.
PMID:30478421
Metazoan evolution of glutamate receptors reveals unreported phylogenetic groups and divergent lineage-specific events.
PMID:30465522
Structure and Function Studies of Asian Corn Borer Ostrinia furnacalis Pheromone Binding Protein2.
PMID:30459333
Degradation of crude oil by mixed cultures of bacteria isolated from the Qinghai-Tibet plateau and comparative analysis of metabolic mechanisms.
PMID:30456621
Formate-nitrite transporters carrying nonprotonatable amide amino acids instead of a central histidine maintain pH-dependent transport.
PMID:30455351
Efficacy of sertraline against Trypanosoma cruzi: an in vitro and in silico study.
PMID:30450114
Thermal Stability of a Mercuric Reductase from the Red Sea Atlantis II Hot Brine Environment as Analyzed by Site-Directed Mutagenesis.
PMID:30446558
Characterization of a novel N-acylhomoserine lactonase, AidP, from Antarctic Planococcus sp.
PMID:30445965
Identification of molecular determinants that govern distinct STIM2 activation dynamics.
PMID:30444880
Effect of C-Terminus Modification in Salmonella typhimurium FliC on Protein Purification Efficacy and Bioactivity.
PMID:30443852
Endogenous amdoparvovirus-related elements reveal insights into the biology and evolution of vertebrate parvoviruses.
PMID:30443409
Dynamic interactions of type I cohesin modules fine-tune the structure of the cellulosome of Clostridium thermocellum.
PMID:30429330
The toxin from a ParDE toxin-antitoxin system found in Pseudomonas aeruginosa offers protection to cells challenged with anti-gyrase antibiotics.
PMID:30427086
MoImd4 mediates crosstalk between MoPdeH-cAMP signalling and purine metabolism to govern growth and pathogenicity in Magnaporthe oryzae.
PMID:30426699
Structural Evidence for the Substrate Channeling of Rice Allene Oxide Cyclase in Biologically Analogous Nazarov Reaction.
PMID:30425978
PSMD12 haploinsufficiency in a neurodevelopmental disorder with autistic features.
PMID:30421579
Structural Variability of EspG Chaperones from Mycobacterial ESX-1, ESX-3, and ESX-5 Type VII Secretion Systems.
PMID:30419243
The Human Gut Colonizer Blastocystis Respires Using Complex II and Alternative Oxidase to Buffer Transient Oxygen Fluctuations in the Gut.
PMID:30406045
Discovery of CDK8/CycC Ligands with a New Virtual Screening Tool.
PMID:30403831
In silico approach to identify non-synonymous SNPs with highest predicted deleterious effect on protein function in human obesity related gene, neuronal growth regulator 1 (NEGR1).
PMID:30402368
Members of the Genus Methylobacter Are Inferred To Account for the Majority of Aerobic Methane Oxidation in Oxic Soils from a Freshwater Wetland.
PMID:30401770
Novel sequence variants in the TLR6 gene associated with advanced breast cancer risk in the Saudi Arabian population.
PMID:30388713
Dynein axonemal intermediate chain 2 plays a role in gametogenesis by activation of Stat3.
PMID:30387321
The Interaction between the Drosophila EAG Potassium Channel and the Protein Kinase CaMKII Involves an Extensive Interface at the Active Site of the Kinase.
PMID:30381148
Caligus rogercresseyi acetylcholinesterase types and variants: a potential marker for organophosphate resistance.
PMID:30376873
The AB loop of oncostatin M (OSM) determines species-specific signaling in humans and mice.
PMID:30373773
Screening of a Novel Polysaccharide Lyase Family 10 Pectate Lyase from Paenibacillus polymyxa KF-1: Cloning, Expression and Characterization.
PMID:30373112
Characterization of Sphingomyelin Phosphodiesterase Expression in Bumblebee (Bombus lantschouensis).
PMID:30371875
Structural consequences of hereditary spastic paraplegia disease-related mutations in kinesin.
PMID:30366951
Structural Analysis of Variability and Interaction of the N-terminal of the Oncogenic Effector CagA of Helicobacter pylori with Phosphatidylserine.
PMID:30360352
Structural and functional insights into the interaction and targeting hub TMD0 of the polypeptide transporter TAPL.
PMID:30353140
Off-axis rotor in Enterococcus hirae V-ATPase visualized by Zernike phase plate single-particle cryo-electron microscopy.
PMID:30353110
Monoubiquitination of ASXLs controls the deubiquitinase activity of the tumor suppressor BAP1.
PMID:30349006
FK506 Resistance of Saccharomyces cerevisiae Pdr5 and Candida albicans Cdr1 Involves Mutations in the Transmembrane Domains and Extracellular Loops.
PMID:30348662
Genome-wide identification of evolutionarily conserved Small Heat-Shock and eight other proteins bearing α-crystallin domain-like in kinetoplastid protists.
PMID:30346990
4-Hydroxyphenylpyruvate Dioxygenase Thermolability Is Responsible for Temperature-Dependent Melanogenesis in Aeromonas salmonicida subsp. salmonicida.
PMID:30341077
High-Resolution Structural Characterization of a New Adeno-associated Virus Serotype 5 Antibody Epitope toward Engineering Antibody-Resistant Recombinant Gene Delivery Vectors.
PMID:30333169
Microevolution in response to transient heme-iron restriction enhances intracellular bacterial community development and persistence.
PMID:30332468
Mapping of Neutralizing Antibody Epitopes on the Envelope of Viruses Obtained from Plasma Samples Exhibiting Broad Cross-Clade Neutralization Potential Against HIV-1.
PMID:30328700
Relevance of Breast Cancer Resistance Protein to Pharmacokinetics of Florfenicol in Chickens: A Perspective from In Vivo and In Vitro Studies.
PMID:30326566
Firefly genomes illuminate parallel origins of bioluminescence in beetles.
PMID:30324905
Differential Effects of Autophagy-Related 10 Protein on HCV Replication and Autophagy Flux Are Mediated by Its Cysteine44 and Cysteine135.
PMID:30319633
S-nitrosylation of the zinc finger protein SRG1 regulates plant immunity.
PMID:30315167
A Viral Protein Restricts Drosophila RNAi Immunity by Regulating Argonaute Activity and Stability.
PMID:30308158
Crystal structure of a dimerization domain of human Caprin-2: similar overall dimeric fold but different molecular surface properties to that of human Caprin-1.
PMID:30304999
Carbamazepine-Mediated Adverse Drug Reactions: CBZ-10,11-epoxide but Not Carbamazepine Induces the Alteration of Peptides Presented by HLA-B∗15:02.
PMID:30302345
Arylvinylpiperazine Amides, a New Class of Potent Inhibitors Targeting QcrB of Mycobacterium tuberculosis.
PMID:30301850
Ligand binding properties of two Brugia malayi fatty acid and retinol (FAR) binding proteins and their vaccine efficacies against challenge infection in gerbils.
PMID:30296268
Can alternative epitope mapping approaches increase the impact of B-cell epitopes in food allergy diagnostics?
PMID:30294841
CCDC114 is mutated in patient with a complex phenotype combining primary ciliary dyskinesia, sensorineural deafness, and renal disease.
PMID:30291279
Placenta-specific 9, a putative secretory protein, induces G2/M arrest and inhibits the proliferation of human embryonic hepatic cells.
PMID:30291214
Pathogenic variants in glutamyl-tRNAGln amidotransferase subunits cause a lethal mitochondrial cardiomyopathy disorder.
PMID:30283131
Antarctic marine ciliates under stress: superoxide dismutases from the psychrophilic Euplotes focardii are cold-active yet heat tolerant enzymes.
PMID:30283056
RIP2 filament formation is required for NOD2 dependent NF-κB signalling.
PMID:30279485
New N-(oxazolylmethyl)-thiazolidinedione Active against Candida albicans Biofilm: Potential Als Proteins Inhibitors.
PMID:30279343
Cryo-EM structures of ASC and NLRC4 CARD filaments reveal a unified mechanism of nucleation and activation of caspase-1.
PMID:30279182
Molecular dynamics provides insight into how N251A and N251Y mutations in the active site of Bacillus licheniformis RN-01 levansucrase disrupt production of long-chain levan.
PMID:30278092
Cryo-EM structure of respiratory complex I at work.
PMID:30277212
Hits-to-Lead Optimization of the Natural Compound 2,4,6-Trihydroxy-3-geranyl-acetophenone (tHGA) as a Potent LOX Inhibitor: Synthesis, Structure-Activity Relationship (SAR) Study, and Computational Assignment.
PMID:30274341
The Diversity of Mammalian Hemoproteins and Microbial Heme Scavengers Is Shaped by an Arms Race for Iron Piracy.
PMID:30271410
The Origin of Mitochondria-Specific Outer Membrane β-Barrels from an Ancestral Bacterial Fragment.
PMID:30265295
Molecular cloning and mRNA expression pattern of Sox4 in Misgurnus anguillicaudatus.
PMID:30262698
Evolution of the calcium feedback steps of vertebrate phototransduction.
PMID:30257895
Antagonistic Pleiotropy in the Bifunctional Surface Protein FadL (OmpP1) during Adaptation of Haemophilus influenzae to Chronic Lung Infection Associated with Chronic Obstructive Pulmonary Disease.
PMID:30254117
Heterocycles 48. Synthesis, Characterization and Biological Evaluation of Imidazo[2,1-b][1,3,4]Thiadiazole Derivatives as Anti-Inflammatory Agents.
PMID:30248903
TbUTP10, a protein involved in early stages of pre-18S rRNA processing in Trypanosoma brucei.
PMID:30248370
Spontaneous severe hypercholesterolemia and atherosclerosis lesions in rabbits with deficiency of low-density lipoprotein receptor (LDLR) on exon 7.
PMID:30243490
Mechanistic insights into the host-microbe interaction and pathogen exclusion mediated by the Mucus-binding protein of Lactobacillus plantarum.
PMID:30242281
Deciphering genome-wide WRKY gene family of Triticum aestivum L. and their functional role in response to Abiotic stress.
PMID:30238225
The intracellular parasite Toxoplasma gondii harbors three druggable FNT-type formate and l-lactate transporters in the plasma membrane.
PMID:30237165
In silico identification of lipid-binding α helices of uncoupling protein 1.
PMID:30233783
Combined functions of two RRMs in Dead-end1 mimic helicase activity to promote nanos1 translation in the germline.
PMID:30230100
Structure of the membrane-assembled retromer coat determined by cryo-electron tomography.
PMID:30224749
Structure-Based Optimization of a Novel Class of Aldehyde Dehydrogenase 1A (ALDH1A) Subfamily-Selective Inhibitors as Potential Adjuncts to Ovarian Cancer Chemotherapy.
PMID:30221940
A New Group of Modular Xylanases in Glycoside Hydrolase Family 8 from Marine Bacteria.
PMID:30217847
WW domain-mediated regulation and activation of E3 ubiquitin ligase Suppressor of Deltex.
PMID:30213861
Glucosylceramide modifies the LPS-induced inflammatory response in macrophages and the orientation of the LPS/TLR4 complex in silico.
PMID:30206272
Small membranous proteins of the TorE/NapE family, crutches for cognate respiratory systems in Proteobacteria.
PMID:30206249
Crystal structure of the modification-dependent SRA-HNH endonuclease TagI.
PMID:30202937
Sinorhizobium meliloti Chemoreceptor McpV Senses Short-Chain Carboxylates via Direct Binding.
PMID:30201781
Mosquito-larvicidal binary toxin receptor protein (Cqm1): crystallization and X-ray crystallographic analysis.
PMID:30198890
Mechanism(s) of action of heavy metals to investigate the regulation of plastidic glucose-6-phosphate dehydrogenase.
PMID:30194387
Importance of Val567 on heme environment and substrate recognition of neuronal nitric oxide synthase.
PMID:30186754
Structural Basis of Pan-Ebolavirus Neutralization by an Antibody Targeting the Glycoprotein Fusion Loop.
PMID:30184505
Comparative sequence and structure analysis of eIF1A and eIF1AD.
PMID:30180896
A new approach to understanding structure-function relationships in cytochromes P450 by targeting terpene metabolism in the wild.
PMID:30170307
Respiratory chain Complex I of unparalleled divergence in diplonemids.
PMID:30166340
Stabilization of the CD81 Large Extracellular Loop with De Novo Disulfide Bonds Improves Its Amenability for Peptide Grafting.
PMID:30150531
A speculation on the tandem fasciclin 1 repeat of FLA4 proteins in angiosperms.
PMID:30148420
Homology modeling, molecular docking, and dynamics of two α-methyl-D-mannoside-specific lectins from Arachis genus.
PMID:30145634
Bi-allelic c.181_183delTGT in BTB domain of KLHL7 is associated with overlapping phenotypes of Crisponi/CISS1-like and Bohring-Opitz like syndrome.
PMID:30142437
Systematic discovery of uncharacterized transcription factors in Escherichia coli K-12 MG1655.
PMID:30137486
Deficient LRRC8A-dependent volume-regulated anion channel activity is associated with male infertility in mice.
PMID:30135305
Caspase-11 auto-proteolysis is crucial for noncanonical inflammasome activation.
PMID:30135078
Prediction of the presence of a seventh ankyrin repeat in IκBε from homology modeling combined with hydrogen-deuterium exchange mass spectrometry (HDX-MS).
PMID:30133030
Human BCDIN3D Is a Cytoplasmic tRNAHis-Specific 5'-Monophosphate Methyltransferase.
PMID:30127802
Identification of novel sesquiterpene synthase genes that mediate the biosynthesis of valerianol, which was an unknown ingredient of tea.
PMID:30127518
Functional characterization of a lytic polysaccharide monooxygenase from the thermophilic fungus Myceliophthora thermophila.
PMID:30125294
Reflections on the evolution of the vertebrate tissue inhibitors of metalloproteinases.
PMID:30125136
A novel glycosyltransferase catalyses the transfer of glucose to glucosylated anthocyanins in purple sweet potato.
PMID:30124996
Conformational switch in the ribosomal protein S1 guides unfolding of structured RNAs for translation initiation.
PMID:30124944
Characterization of the β-defensin genes in giant panda.
PMID:30120296
hCALCRL mutation causes autosomal recessive nonimmune hydrops fetalis with lymphatic dysplasia.
PMID:30115739
Characterization and expression of a long neuropeptide F (NPF) receptor in the Chagas disease vector Rhodnius prolixus.
PMID:30114273
Novel frame shift mutation in ERCC6 leads to a severe form of Cockayne syndrome with postnatal growth failure and early death: A case report and brief literature review.
PMID:30113454
Contribution of RAD51D germline mutations in breast and ovarian cancer in Greece.
PMID:30111881
Integrative metagenomic and biochemical studies on rifamycin ADP-ribosyltransferases discovered in the sediment microbiome.
PMID:30108275
Discovery of nonnucleoside inhibitors of polymerase from infectious pancreatic necrosis virus (IPNV).
PMID:30104863
The Intracellular Cyclophilin PpiB Contributes to the Virulence of Staphylococcus aureus Independently of Its Peptidyl-Prolyl cis/trans Isomerase Activity.
PMID:30104214
Cryo-EM structure of the SARS coronavirus spike glycoprotein in complex with its host cell receptor ACE2.
PMID:30102747
Redox regulation of GRPEL2 nucleotide exchange factor for mitochondrial HSP70 chaperone.
PMID:30098457
OpuF, a New Bacillus Compatible Solute ABC Transporter with a Substrate-Binding Protein Fused to the Transmembrane Domain.
PMID:30097444
Electron-Microscopy-Based Epitope Mapping Defines Specificities of Polyclonal Antibodies Elicited during HIV-1 BG505 Envelope Trimer Immunization.
PMID:30097292
Inward- and outward-facing homology modeling of human concentrative nucleoside transporter 3 (hCNT3) predicts an elevator-type transport mechanism.
PMID:30096006
The altered activity of P53 signaling pathway by STK11 gene mutations and its cancer phenotype in Peutz-Jeghers syndrome.
PMID:30092773
Two Compound Heterozygous Were Identified in SLC26A4 Gene in Two Chinese Families With Enlarged Vestibular Aqueduct.
PMID:30086623
Modeling the structural implications of an alternatively spliced Exoc3l2, a paralog of the tunneling nanotube-forming M-Sec.
PMID:30086153
Incompatible Translation Drives a Convergent Evolution and Viral Attenuation During the Development of Live Attenuated Vaccine.
PMID:30073153
Lysine-Specific Demethylase 1A as a Promising Target in Acute Myeloid Leukemia.
PMID:30073149
Molecular characterization, modeling, and docking analysis of late phytic acid biosynthesis pathway gene, inositol polyphosphate 6-/3-/5-kinase, a potential candidate for developing low phytate crops.
PMID:30073129
Botulinum Neurotoxin F Subtypes Cleaving the VAMP-2 Q58⁻K59 Peptide Bond Exhibit Unique Catalytic Properties and Substrate Specificities.
PMID:30071628
In silico analysis of SLC3A1 and SLC7A9 mutations in Iranian patients with Cystinuria.
PMID:30069816
Deciphering the targets of retroviral protease inhibitors in Plasmodium berghei.
PMID:30067811
Baicalin Depresses the Sympathoexcitatory Reflex Induced by Myocardial Ischemia via the Dorsal Root Ganglia.
PMID:30065662
EGFL7 enhances surface expression of integrin α5β1 to promote angiogenesis in malignant brain tumors.
PMID:30065025
Structure of a mitochondrial fission dynamin in the closed conformation.
PMID:30061604
Spread of MCR-3 Colistin Resistance in China: An Epidemiological, Genomic and Mechanistic Study.
PMID:30061009
Lytic gene expression in the temperate bacteriophage GIL01 is activated by a phage-encoded LexA homologue.
PMID:30053203
Effect of Active Site Pocket Structure Modification of D-Stereospecific Amidohydrolase on the Recognition of Stereospecific and Hydrophobic Substrates.
PMID:30051300
Structure-function analyses of the bacterial zinc metalloprotease effector protein GtgA uncover key residues required for deactivating NF-κB.
PMID:30049795
In silico mutational analysis and identification of stability centers in human interleukin-4.
PMID:30046620
Comparative Study of Carborane- and Phenyl-Modified Adenosine Derivatives as Ligands for the A2A and A3 Adenosine Receptors Based on a Rigid in Silico Docking and Radioligand Replacement Assay.
PMID:30044380
Cryo-EM structure of the benzodiazepine-sensitive α1β1γ2S tri-heteromeric GABAA receptor in complex with GABA.
PMID:30044221
Calcium-binding proteins that are type B″ regulatory subunits of phosphatase 2A in Giardia intestinalis.
PMID:30043281
MtMTP2-Facilitated Zinc Transport Into Intracellular Compartments Is Essential for Nodule Development in Medicago truncatula.
PMID:30042781
Arabidopsis Kunitz Trypsin Inhibitors in Defense Against Spider Mites.
PMID:30042779
Whole genome SNP-associated signatures of local adaptation in honeybees of the Iberian Peninsula.
PMID:30042407
Selection of an ASIC1a-blocking combinatorial antibody that protects cells from ischemic death.
PMID:30042215
Improving the diagnosis of cobalamin and related defects by genomic analysis, plus functional and structural assessment of novel variants.
PMID:30041674
Antifungal activity of Cardiospermum halicacabum L. (Sapindaceae) against Trichophyton rubrum occurs through molecular interaction with fungal Hsp90.
PMID:30034223
The positive inotropic agent DPI-201106 selectively reverses ABCB1-mediated multidrug resistance in cancer cell lines.
PMID:30031116
Human ATP-binding cassette transporters ABCB1 and ABCG2 confer resistance to histone deacetylase 6 inhibitor ricolinostat (ACY-1215) in cancer cell lines.
PMID:30028995
Plasmodium falciparum RUVBL3 protein: a novel DNA modifying enzyme and an interacting partner of essential HAT protein MYST.
PMID:30026605
SIS3, a specific inhibitor of Smad3 reverses ABCB1- and ABCG2-mediated multidrug resistance in cancer cell lines.
PMID:30026175
Computational Study Reveals the Molecular Mechanism of the Interaction between the Efflux Inhibitor PAβN and the AdeB Transporter from Acinetobacter baumannii.
PMID:30023681
Crystal structure of an L chain optimised 14F7 anti-ganglioside Fv suggests a unique tumour-specificity through an unusual H-chain CDR3 architecture.
PMID:30022069
Monitoring Viral Genetic Variation as a Tool To Improve Molecular Diagnostics for Mumps Virus.
PMID:30021826
Characterization of esterase activity from an Acetomicrobium hydrogeniformans enzyme with high structural stability in extreme conditions.
PMID:30014242
Structural determinants of specificity and regulation of activity in the allosteric loop network of human KLK8/neuropsin.
PMID:30013126
Characterization of the AmpC β-Lactamase from Burkholderia multivorans.
PMID:30012762
Refining a steroidogenic model: an analysis of RNA-seq datasets from insect prothoracic glands.
PMID:30005604
In Silico evaluation and identification of fungi capable of producing endo-inulinase enzyme.
PMID:30001376
Proteomics and Phosphoproteomics of Heat Stress-Responsive Mechanisms in Spinach.
PMID:29997633
Mild clinical features of isolated methylmalonic acidemia associated with a novel variant in the MMAA gene in two Chinese siblings.
PMID:29996803
The rice white green leaf 2 gene causes defects in chloroplast development and affects the plastid ribosomal protein S9.
PMID:29995230
Study of specific nanoenvironments containing α-helices in all-α and (α+β)+(α/β) proteins.
PMID:29990352
Computational approach to unravel the impact of missense mutations of proteins (D2HGDH and IDH2) causing D-2-hydroxyglutaric aciduria 2.
PMID:29987523
Molecular Insights into Functional Differences between mcr-3- and mcr-1-Mediated Colistin Resistance.
PMID:29987148
MORC Domain Definition and Evolutionary Analysis of the MORC Gene Family in Green Plants.
PMID:29982569
Identification of Antifungal Targets Based on Computer Modeling.
PMID:29973534
Stable isotope informed genome-resolved metagenomics reveals that Saccharibacteria utilize microbially-processed plant-derived carbon.
PMID:29970182
Characterization of Three Small Proteins in Brucella abortus Linked to Fucose Utilization.
PMID:29967118
Plasmodium vivax Merozoite Surface Protein 1 Paralog as a Mediator of Parasite Adherence to Reticulocytes.
PMID:29967091
Computational identification and evolutionary analysis of toxins in Mosquitocidal Bacillus thuringiensis strain S2160-1.
PMID:29963353
In Silico Screening of Isocitrate Lyase for Novel Anti-Buruli Ulcer Natural Products Originating from Africa.
PMID:29954088
Identification of DEAD-Box RNA Helicase DDX41 as a Trafficking Protein That Involves in Multiple Innate Immune Signaling Pathways in a Zebrafish Model.
PMID:29942316
Temperature-induced changes in the wheat phosphoproteome reveal temperature-regulated interconversion of phosphoforms.
PMID:29939309
A Novel Tomato Fusarium Wilt Tolerance Gene.
PMID:29937759
The Cyanobacterial Ribosomal-Associated Protein LrtA from Synechocystis sp. PCC 6803 Is an Oligomeric Protein in Solution with Chameleonic Sequence Properties.
PMID:29937518
In Silico Analysis of the Quorum Sensing Metagenome in Environmental Biofilm Samples.
PMID:29930547
Influenza D virus M2 protein exhibits ion channel activity in Xenopus laevis oocytes.
PMID:29927982
Divergent Small Tim Homologues Are Associated with TbTim17 and Critical for the Biogenesis of TbTim17 Protein Complexes in Trypanosoma brucei.
PMID:29925672
Synthesis and molecular modelling studies of pyrimidinones and pyrrolo[3,4-d]-pyrimidinodiones as new antiplasmodial compounds.
PMID:29924131
Cryo-EM structure of human mitochondrial trifunctional protein.
PMID:29915090
A Mechanism for the Activation of the Influenza Virus Transcriptase.
PMID:29910112
Introduction of novel thermostable α-amylases from genus Anoxybacillus and proposing to group the Bacillaceae related α-amylases under five individual GH13 subfamilies.
PMID:29904894
Costimulatory Function of Cd58/Cd2 Interaction in Adaptive Humoral Immunity in a Zebrafish Model.
PMID:29904386
Enteric bacteria boost defences against oxidative stress in Entamoeba histolytica.
PMID:29899530
NEDD9 targets COL3A1 to promote endothelial fibrosis and pulmonary arterial hypertension.
PMID:29899023
Live and let die: Hydrogen peroxide production by the commensal flora and its role in maintaining a symbiotic microbiome.
PMID:29897662
A Novel ShK-Like Toxic Peptide from the Transcriptome of the Cnidarian Palythoa caribaeorum Displays Neuroprotection and Cardioprotection in Zebrafish.
PMID:29895785
Characterization of C-ring component assembly in flagellar motors from amino acid coevolution.
PMID:29892378
Escherichia coli B2 strains prevalent in inflammatory bowel disease patients have distinct metabolic capabilities that enable colonization of intestinal mucosa.
PMID:29890970
Pandemic Avian Influenza and Intra/Interhaemagglutinin Subtype Electrostatic Variation among Viruses Isolated from Avian, Mammalian, and Human Hosts.
PMID:29888260
Adaptive genetic variation at three loci in South African vervet monkeys (Chlorocebus pygerythrus) and the role of selection within primates.
PMID:29888138
Wireless control of cellular function by activation of a novel protein responsive to electromagnetic fields.
PMID:29884813
Isolation and Semi Quantitative PCR of Na+/H+ Antiporter (SOS1 and NHX) Genes under Salinity Stress in Kochia scoparia.
PMID:29881329
Characterization of a novel MYO3A missense mutation associated with a dominant form of late onset hearing loss.
PMID:29880844
Venom allergen-like protein 28 in Clonorchis sinensis: four epitopes on its surface and the potential role of Cys124 for its conformational stability.
PMID:29876859
Crystal structure of arginine-bound lysosomal transporter SLC38A9 in the cytosol-open state.
PMID:29872228
Identification of Putative Precursor Genes for the Biosynthesis of Cannabinoid-Like Compound in Radula marginata.
PMID:29868043
Convergent Loss of ABC Transporter Genes From Clostridioides difficile Genomes Is Associated With Impaired Tyrosine Uptake and p-Cresol Production.
PMID:29867812
The Odorant Binding Protein 6 Expressed in Sensilla Chaetica Displays Preferential Binding Affinity to Host Plants Volatiles in Ectropis obliqua.
PMID:29867573
Evolutionary convergence in lignin-degrading enzymes.
PMID:29866821
In silico prediction of T- and B-cell epitopes in PmpD: First step towards to the design of a Chlamydia trachomatis vaccine.
PMID:29866599
Large set data mining reveals overexpressed GPCRs in prostate and breast cancer: potential for active targeting with engineered anti-cancer nanomedicines.
PMID:29861840
A dominant variant in the PDE1C gene is associated with nonsyndromic hearing loss.
PMID:29860631
Engineering Bacillus pumilus alkaline serine protease to increase its low-temperature proteolytic activity by directed evolution.
PMID:29859069
Specific binding between Bacillus thuringiensis Cry9Aa and Vip3Aa toxins synergizes their toxicity against Asiatic rice borer (Chilo suppressalis).
PMID:29858245
Transcriptomics reveals the molecular processes of light-induced rapid darkening of the non-obligate cave dweller Oreolalax rhodostigmatus (Megophryidae, Anura) and their genetic basis of pigmentation strategy.
PMID:29855256
Gain-of-function KCNJ6 Mutation in a Severe Hyperkinetic Movement Disorder Phenotype.
PMID:29852244
Genome-Wide Identification and Characterization of Fox Genes in the Honeybee, Apis cerana, and Comparative Analysis with Other Bee Fox Genes.
PMID:29850474
Salmonella enterica serovar Typhimurium has three transketolase enzymes contributing to the pentose phosphate pathway.
PMID:29848552
HSYMDOCK: a docking web server for predicting the structure of protein homo-oligomers with Cn or Dn symmetry.
PMID:29846641
Use of Protein Kinase-Focused Compound Libraries for the Discovery of New Inositol Phosphate Kinase Inhibitors.
PMID:29842835
An orphan kinesin controls trypanosome morphology transitions by targeting FLAM3 to the flagellum.
PMID:29813136
Cdc48-like protein of actinobacteria (Cpa) is a novel proteasome interactor in mycobacteria and related organisms.
PMID:29809155
Computational-based structural, functional and phylogenetic analysis of Enterobacter phytases.
PMID:29805952
Molecular characterization of canine parvovirus variants (CPV-2a, CPV-2b, and CPV-2c) based on the VP2 gene in affected domestic dogs in Ecuador.
PMID:29805214
Cytokinin perception in potato: new features of canonical players.
PMID:29800344
HotSpot Wizard 3.0: web server for automated design of mutations and smart libraries based on sequence input information.
PMID:29796670
Comparative inhibitory profile and distribution of bacterial PARPs, using Clostridioides difficile CD160 PARP as a model.
PMID:29795234
SWISS-MODEL: homology modelling of protein structures and complexes.
PMID:29788355
A novel adeno-associated virus capsid with enhanced neurotropism corrects a lysosomal transmembrane enzyme deficiency.
PMID:29788236
Catalytic Bases and Stereocontrol in Lamiaceae Class II Diterpene Cyclases.
PMID:29787239
Fungal-type carbohydrate binding modules from the coccolithophore Emiliania huxleyi show binding affinity to cellulose and chitin.
PMID:29782536
Genome Sequencing and Analysis of the Peanut B-Genome Progenitor (Arachis ipaensis).
PMID:29774047
The trimeric solution structure and fucose-binding mechanism of the core fucosylation-specific lectin PhoSL.
PMID:29773815
A Pelota-like gene regulates root development and defence responses in rice.
PMID:29771278
Novel aggrecan variant, p. Gln2364Pro, causes severe familial nonsyndromic adult short stature and poor growth hormone response in Chinese children.
PMID:29769040
ScGAI is a key regulator of culm development in sugarcane.
PMID:29767776
Computational analysis of the receptor binding specificity of novel influenza A/H7N9 viruses.
PMID:29764421
Methylglucosylation of aromatic amino and phenolic moieties of drug-like biosynthons by combinatorial biosynthesis.
PMID:29760061
Defining ICR-Mo, an intrinsic colistin resistance determinant from Moraxella osloensis.
PMID:29758020
Exploring the Interaction Mechanism Between Cyclopeptide DC3 and Androgen Receptor Using Molecular Dynamics Simulations and Free Energy Calculations.
PMID:29755968
Influenza Virus: A Master Tactician in Innate Immune Evasion and Novel Therapeutic Interventions.
PMID:29755452
Pheromone Binding Protein EhipPBP1 Is Highly Enriched in the Male Antennae of the Seabuckthorn Carpenterworm and Is Binding to Sex Pheromone Components.
PMID:29755369
Mutations in PPCS, Encoding Phosphopantothenoylcysteine Synthetase, Cause Autosomal-Recessive Dilated Cardiomyopathy.
PMID:29754768
A Functional Study Identifying Critical Residues Involving Metal Transport Activity and Selectivity in Natural Resistance-Associated Macrophage Protein 3 in Arabidopsis thaliana.
PMID:29748478
Expression and Interaction Analysis among Saffron ALDHs and Crocetin Dialdehyde.
PMID:29747375
Structure of a TRPM2 channel in complex with Ca2+ explains unique gating regulation.
PMID:29745897
Comprehensive analyses of the BES1 gene family in Brassica napus and examination of their evolutionary pattern in representative species.
PMID:29743014
A molecular dynamics investigation of CDK8/CycC and ligand binding: conformational flexibility and implication in drug discovery.
PMID:29737445
MIKCC-type MADS-box genes in Rosa chinensis: the remarkable expansion of ABCDE model genes and their roles in floral organogenesis.
PMID:29736250
A persulfidation-based mechanism controls aquaporin-8 conductance.
PMID:29732408
Improved L-ornithine production in Corynebacterium crenatum by introducing an artificial linear transacetylation pathway.
PMID:29728854
Isolation and characterization of 4-hydroxy-3-methylbut-2-enyl diphosphate reductase gene from Botryococcus braunii, race B.
PMID:29725892
CD22-Binding Synthetic Sialosides Regulate B Lymphocyte Proliferation Through CD22 Ligand-Dependent and Independent Pathways, and Enhance Antibody Production in Mice.
PMID:29725338
Species-Specific Involvement of Integrin αIIbβ3 in a Monoclonal Antibody CH12 Triggers Off-Target Thrombocytopenia in Cynomolgus Monkeys.
PMID:29724685
A broadly conserved NERD genetically interacts with the exocyst to affect root growth and cell expansion.
PMID:29722827
Glutathione modulates the expression of heat shock proteins via the transcription factors BZIP10 and MYB21 in Arabidopsis.
PMID:29722824
Pathogen-Specific Binding Soluble Down Syndrome Cell Adhesion Molecule (Dscam) Regulates Phagocytosis via Membrane-Bound Dscam in Crab.
PMID:29720978
Structural principles of distinct assemblies of the human α4β2 nicotinic receptor.
PMID:29720657
Medicago Plants Control Nodulation by Regulating Proteolysis of the Receptor-Like Kinase DMI2.
PMID:29717018
ELMOD3, a novel causative gene, associated with human autosomal dominant nonsyndromic and progressive hearing loss.
PMID:29713870
Novel LAMA2 Gene Mutations Associated with Merosin-Deficient Congenital Muscular Dystrophy.
PMID:29707938
Structural Insight Into the Role of Mutual Polymorphism and Conservatism in the Contact Zone of the NFR5-K1 Heterodimer With the Nod Factor.
PMID:29706972
Phosphatidylinositol-3,5-bisphosphate lipid-binding-induced activation of the human two-pore channel 2.
PMID:29705952
The Ustilago maydis repetitive effector Rsp3 blocks the antifungal activity of mannose-binding maize proteins.
PMID:29703884
Structure-Function Mutational Analysis and Prediction of the Potential Impact of High Risk Non-Synonymous Single-Nucleotide Polymorphism on Poliovirus 2A Protease Stability Using Comprehensive Informatics Approaches.
PMID:29701718
Structure of the receptor-activated human TRPC6 and TRPC3 ion channels.
PMID:29700422
Isolation and molecular characterization of novel glucarpidases: Enzymes to improve the antibody directed enzyme pro-drug therapy for cancer treatment.
PMID:29698433
Putative Connections Between Nitrate Reductase S-Nitrosylation and NO Synthesis Under Pathogen Attacks and Abiotic Stresses.
PMID:29696031
A structural study of the complex between neuroepithelial cell transforming gene 1 (Net1) and RhoA reveals a potential anticancer drug hot spot.
PMID:29695506
Design, Synthesis, and Docking Studies of New Torin2 Analogs as Potential ATR/mTOR Kinase Inhibitors.
PMID:29695073
Rotation-Activated and Cooperative Zipping Characterize Class I Viral Fusion Protein Dynamics.
PMID:29694865
Non-canonical role of the SNARE protein Ykt6 in autophagosome-lysosome fusion.
PMID:29694367
Involvement of a host Cathepsin L in symbiont-induced cell death.
PMID:29692003
A homozygous mutation p.Arg2167Trp in FREM2 causes isolated cryptophthalmos.
PMID:29688405
The IL-33-PIN1-IRAK-M axis is critical for type 2 immunity in IL-33-induced allergic airway inflammation.
PMID:29686383
The Two-Component Signaling System VraSRss Is Critical for Multidrug Resistance and Full Virulence in Streptococcus suis Serotype 2.
PMID:29685990
Close and regular surveillance is key to prevent severe complications for Peutz-Jeghers syndrome patients without gastrointestinal polyps: case report of a novel STK11 mutation (c.471_472delCT) in a Chinese girl.
PMID:29685139
Molecular Cancer Imaging in the Second Near-Infrared Window Using a Renal-Excreted NIR-II Fluorophore-Peptide Probe.
PMID:29682821
Structural Basis for Teneurin Function in Circuit-Wiring: A Toxin Motif at the Synapse.
PMID:29677516
An innovative immunotherapeutic strategy for ovarian cancer: CLEC10A and glycomimetic peptides.
PMID:29665849
Structural studies on radiopharmaceutical DOTA-minigastrin analogue (CP04) complexes and their interaction with CCK2 receptor.
PMID:29663167
HU of Streptococcus pneumoniae Is Essential for the Preservation of DNA Supercoiling.
PMID:29662473
Genetic variability in the sdrD gene in Staphylococcus aureus from healthy nasal carriers.
PMID:29661152
Structural basis for ATP-dependent chromatin remodelling by the INO80 complex.
PMID:29643509
An m6A-YTH Module Controls Developmental Timing and Morphogenesis in Arabidopsis.
PMID:29643069
Glycosylation of Hemagglutinin and Neuraminidase of Influenza A Virus as Signature for Ecological Spillover and Adaptation among Influenza Reservoirs.
PMID:29642453
Biophysical characterization and molecular simulation of electrostatically driven self-association of a single-chain antibody.
PMID:29637646
Analysis of HIV-1 envelope evolution suggests antibody-mediated selection of common epitopes among Chinese former plasma donors from a narrow-source outbreak.
PMID:29636501
An Evolutionarily Conserved Mechanism for Intrinsic and Transferable Polymyxin Resistance.
PMID:29636432
New World feline APOBEC3 potently controls inter-genus lentiviral transmission.
PMID:29636069
The single berberine bridge enzyme homolog of Physcomitrella patens is a cellobiose oxidase.
PMID:29633551
Disentangling the molecular determinants for Cenp-F localization to nuclear pores and kinetochores.
PMID:29632243
Insight into the Significance of Aspergillus fumigatus cyp51A Polymorphisms.
PMID:29632011
Disease-Causing Mutations in the G Protein Gαs Subvert the Roles of GDP and GTP.
PMID:29628140
Substituents at the C3' and C3'N positions are critical for taxanes to overcome acquired resistance of cancer cells to paclitaxel.
PMID:29625142
Mutations Conferring Increased Sensitivity to Tripartite Motif 22 Restriction Accumulated Progressively in the Nucleoprotein of Seasonal Influenza A (H1N1) Viruses between 1918 and 2009.
PMID:29624498
Patient with multiple acyl-CoA dehydrogenase deficiency disease and ETFDH mutations benefits from riboflavin therapy: a case report.
PMID:29615056
Multilevel Differential Control of Hormone Gene Expression Programs by hnRNP L and LL in Pituitary Cells.
PMID:29610151
Solution scattering study of the Bacillus subtilis PgdS enzyme involved in poly-γ-glutamic acids degradation.
PMID:29608608
Mutations in the voltage-sensing domain affect the alternative ion permeation pathway in the TRPM3 channel.
PMID:29604058
Computational Insight Into the Structural Organization of Full-Length Toll-Like Receptor 4 Dimer in a Model Phospholipid Bilayer.
PMID:29593733
Amino Acid Substitutions HA A150V, PA A343T, and PB2 E627K Increase the Virulence of H5N6 Influenza Virus in Mice.
PMID:29593694
The degenerin region of the human bile acid-sensitive ion channel (BASIC) is involved in channel inhibition by calcium and activation by bile acids.
PMID:29589117
Long-lived rodents reveal signatures of positive selection in genes associated with lifespan.
PMID:29570707
Dual binding in cohesin-dockerin complexes: the energy landscape and the role of short, terminal segments of the dockerin module.
PMID:29568013
Cryo-EM structure of the polycystic kidney disease-like channel PKD2L1.
PMID:29567962
Molecular control of gene expression by Brucella BaaR, an IclR-type transcriptional repressor.
PMID:29567835
Role of the Extremolytes Ectoine and Hydroxyectoine as Stress Protectants and Nutrients: Genetics, Phylogenomics, Biochemistry, and Structural Analysis.
PMID:29565833
Architecture of the Saccharomyces cerevisiae NuA4/TIP60 complex.
PMID:29559617
Cryo-EM structure of an early precursor of large ribosomal subunit reveals a half-assembled intermediate.
PMID:29557065
Duplicated TLR5 of zebrafish functions as a heterodimeric receptor.
PMID:29555749
Retinal isomerization and water-pore formation in channelrhodopsin-2.
PMID:29555736
A novel cold-adapted esterase from Enterobacter cloacae: Characterization and improvement of its activity and thermostability via the site of Tyr193Cys.
PMID:29554914
A public antibody lineage that potently inhibits malaria infection through dual binding to the circumsporozoite protein.
PMID:29554084
Neurobehavioral Effects of Cephalosporins: Assessment of Locomotors Activity, Motor and Sensory Development in Zebrafish.
PMID:29551974
Characterization and expression analyses of somatolactin-α and -β genes in rare minnows (Gobiocypris rarus) following waterborne cadmium exposure.
PMID:29550894
Chimeric Fatty Acyl-Acyl Carrier Protein Thioesterases Provide Mechanistic Insight into Enzyme Specificity and Expression.
PMID:29549102
Structures of Teneurin adhesion receptors reveal an ancient fold for cell-cell interaction.
PMID:29540701
Molecular Insights into the Mechanisms of SUN1 Oligomerization in the Nuclear Envelope.
PMID:29539404
Cooperative recruitment of Yan via a high-affinity ETS supersite organizes repression to confer specificity and robustness to cardiac cell fate specification.
PMID:29535190
A horizontally gene transferred copper resistance locus confers hyper-resistance to antibacterial copper toxicity and enables survival of community acquired methicillin resistant Staphylococcus aureus USA300 in macrophages.
PMID:29521441
Association of μ-Calpain and Calpastatin Polymorphisms with Meat Tenderness in a Brahman-Angus Population.
PMID:29520298
Novel mutations associated with pyruvate kinase deficiency in Brazil.
PMID:29519373
Coevolution of the Toll-Like Receptor 4 Complex with Calgranulins and Lipopolysaccharide.
PMID:29515592
The FBH family of bHLH transcription factors controls ACC synthase expression in sugarcane.
PMID:29514290
Phenotype of CNTNAP1: a study of patients demonstrating a specific severe congenital hypomyelinating neuropathy with survival beyond infancy.
PMID:29511323
The corticotropin releasing factor binding protein: A strange case of Dr. Jekyll and Mr. Hyde in the stress system?
PMID:29510883
A recombinant Fasciola gigantica 14-3-3 epsilon protein (rFg14-3-3e) modulates various functions of goat peripheral blood mononuclear cells.
PMID:29510740
A novel, homozygous mutation in desert hedgehog (DHH) in a 46, XY patient with dysgenetic testes presenting with primary amenorrhoea: a case report.
PMID:29507583
Clinical phenotype and molecular analysis of a homozygous ABCB11 mutation responsible for progressive infantile cholestasis.
PMID:29507376
There's no place like OM: Vesicular sorting and secretion of the peptidylarginine deiminase of Porphyromonas gingivalis.
PMID:29505395
SIRT2 deacetylase regulates the activity of GSK3 isoforms independent of inhibitory phosphorylation.
PMID:29504933
Structural and functional studies on Pseudomonas aeruginosa DspI: implications for its role in DSF biosynthesis.
PMID:29500457
Molecular docking based screening of Noggin inhibitors.
PMID:29497255
Mycobacterium tuberculosis H37Rv LpqG Protein Peptides Can Inhibit Mycobacterial Entry through Specific Interactions.
PMID:29495456
Characterization of the Lytic Capability of a LysK-Like Endolysin, Lys-phiSA012, Derived from a Polyvalent Staphylococcus aureus Bacteriophage.
PMID:29495305
Molecular docking, molecular modeling, and molecular dynamics studies of azaisoflavone as dual COX-2 inhibitors and TP receptor antagonists.
PMID:29480373
Novel CARMIL2 Mutations in Patients with Variable Clinical Dermatitis, Infections, and Combined Immunodeficiency.
PMID:29479355
Allosteric Effector ppGpp Potentiates the Inhibition of Transcript Initiation by DksA.
PMID:29478808
Biallelic Mutations in ATP5F1D, which Encodes a Subunit of ATP Synthase, Cause a Metabolic Disorder.
PMID:29478781
A chemical genetic approach to engineer phototropin kinases for substrate labeling.
PMID:29475950
Error-prone PCR mutagenesis and reverse bacterial two-hybrid screening identify a mutation in asparagine 53 of the Staphylococcus aureus ESAT6-like component EsxB that perturbs interaction with EsxD.
PMID:29473132
The C-terminal helix of ribosomal P stalk recognizes a hydrophobic groove of elongation factor 2 in a novel fashion.
PMID:29471537
Formation of RNA Granule-Derived Capsid Assembly Intermediates Appears To Be Conserved between Human Immunodeficiency Virus Type 1 and the Nonprimate Lentivirus Feline Immunodeficiency Virus.
PMID:29467316
Unraveling the sequence of cytosolic reactions in the export of GspB adhesin from Streptococcus gordonii.
PMID:29462788
Mechanistic insights into transferable polymyxin resistance among gut bacteria.
PMID:29462787
Transient receptor potential vanilloid 4 (TRPV4) activation by arachidonic acid requires protein kinase A-mediated phosphorylation.
PMID:29462784
Circulatory white spot syndrome virus in South-West region of Bangladesh from 2014 to 2017: molecular characterization and genetic variation.
PMID:29460184
Molecular, biochemical and kinetic analysis of a novel, thermostable lipase (LipSm) from Stenotrophomonas maltophilia Psi-1, the first member of a new bacterial lipase family (XVIII).
PMID:29456971
Comparative phylogenetic and expression analysis of small GTPases families in legume and non-legume plants.
PMID:29452030
Novel hereditary spherocytosis-associated splice site mutation in the ANK1 gene caused by parental gonosomal mosaicism.
PMID:29449435
Structural basis for the glycosyltransferase activity of the Salmonella effector SseK3.
PMID:29449376
The synaptotagmin C2B domain calcium-binding loops modulate the rate of fusion pore expansion.
PMID:29444959
A Comparative Study of Human Saposins.
PMID:29443946
Differential Expression of Six Rnase2 and Three Rnase3 Paralogs Identified in Blunt Snout Bream in Response to Aeromonas hydrophila Infection.
PMID:29443944
Comparative analysis of plant isochorismate synthases reveals structural mechanisms underlying their distinct biochemical properties.
PMID:29436485
Insight into Phosphatidylinositol-Dependent Membrane Localization of the Innate Immune Adaptor Protein Toll/Interleukin 1 Receptor Domain-Containing Adaptor Protein.
PMID:29434596
The Extracellular Domain of Pollen Receptor Kinase 3 is structurally similar to the SERK family of co-receptors.
PMID:29434276
The C-terminal cytosolic domain of the human zinc transporter ZnT8 and its diabetes risk variant.
PMID:29430817
Characterization of OglDREB2A gene from African rice (Oryza glaberrima), comparative analysis and its transcriptional regulation under salinity stress.
PMID:29430353
Oral recombinant Lactobacillus vaccine targeting the intestinal microfold cells and dendritic cells for delivering the core neutralizing epitope of porcine epidemic diarrhea virus.
PMID:29426335
Unique pharmacological properties of serotoninergic G-protein coupled receptors from cestodes.
PMID:29425245
Nanoparticle-Encapsulated Curcumin Inhibits Diabetic Neuropathic Pain Involving the P2Y12 Receptor in the Dorsal Root Ganglia.
PMID:29422835
Importance of a Laccase Gene (Lcc1) in the Development of Ganoderma tsugae.
PMID:29415422
Analysis of Homologs of Cry-toxin Receptor-Related Proteins in the Midgut of a Non-Bt Target, Nilaparvata lugens (Stål) (Hemiptera: Delphacidae).
PMID:29415259
NS2 proteases from hepatitis C virus and related hepaciviruses share composite active sites and previously unrecognized intrinsic proteolytic activities.
PMID:29415072
Molecular characterization of the recombinant protein RmLTI-BmCG-LTB: Protective immunity against Rhipicephalus (Boophilus) microplus.
PMID:29415034
Crystal structure reveals vaccine elicited bactericidal human antibody targeting a conserved epitope on meningococcal fHbp.
PMID:29410413
SAAMP 2.0: An algorithm to predict genotype-phenotype correlation of lysosomal storage diseases.
PMID:29396849
Molecular Docking, Pharmacophore, and 3D-QSAR Approach: Can Adenine Derivatives Exhibit Significant Inhibitor Towards Ebola Virus?
PMID:29387271
The PUF Protein Family: Overview on PUF RNA Targets, Biological Functions, and Post Transcriptional Regulation.
PMID:29385744
The C-terminal region of translesion synthesis DNA polymerase η is partially unstructured and has high conformational flexibility.
PMID:29385534
Two novel deep-sea sediment metagenome-derived esterases: residue 199 is the determinant of substrate specificity and preference.
PMID:29382330
Discovery of Selective, Substrate-Competitive, and Passive Membrane Permeable Glycogen Synthase Kinase-3β Inhibitors: Synthesis, Biological Evaluation, and Molecular Modeling of New C-Glycosylflavones.
PMID:29381861
Hydrogen sulfide increases glutathione biosynthesis, and glucose uptake and utilisation in C2C12 mouse myotubes.
PMID:29378451
Fungal Screening on Olive Oil for Extracellular Triacylglycerol Lipases: Selection of a Trichoderma harzianum Strain and Genome Wide Search for the Genes.
PMID:29370083
Shielding and activation of a viral membrane fusion protein.
PMID:29367607
Three-dimensional spatial analysis of missense variants in RTEL1 identifies pathogenic variants in patients with Familial Interstitial Pneumonia.
PMID:29361909
The common bean COK-4 and the Arabidopsis FER kinase domain share similar functions in plant growth and defence.
PMID:29352746
Phosphate signaling through alternate conformations of the PstSCAB phosphate transporter.
PMID:29351743
A homozygous missense variant in VWA2, encoding an interactor of the Fraser-complex, in a patient with vesicoureteral reflux.
PMID:29351342
6-OHDA-induced dopaminergic neurodegeneration in Caenorhabditis elegans is promoted by the engulfment pathway and inhibited by the transthyretin-related protein TTR-33.
PMID:29346382
Mutations in Caenorhabditis elegans neuroligin-like glit-1, the apoptosis pathway and the calcium chaperone crt-1 increase dopaminergic neurodegeneration after 6-OHDA treatment.
PMID:29346364
Remarkable similarity in Plasmodium falciparum and Plasmodium vivax geranylgeranyl diphosphate synthase dynamics and its implication for antimalarial drug design.
PMID:29345110
A search for ceramide binding proteins using bifunctional lipid analogs yields CERT-related protein StarD7.
PMID:29343537
Copy Number Variation in SOX6 Contributes to Chicken Muscle Development.
PMID:29342086
In silico identification and experimental validation of amino acid motifs required for the Rho-of-plants GTPase-mediated activation of receptor-like cytoplasmic kinases.
PMID:29340786
Assessment of antimicrobial and wound healing effects of Brevinin-2Ta against the bacterium Klebsiella pneumoniae in dermally-wounded rats.
PMID:29340060
Biochemical and genetic characterization of a novel metallo-β-lactamase from marine bacterium Erythrobacter litoralis HTCC 2594.
PMID:29339760
New Shuttle Vectors for Gene Cloning and Expression in Multidrug-Resistant Acinetobacter Species.
PMID:29339383
Cryo-EM structure of the exocyst complex.
PMID:29335562
Identification of Cross Reactive Antigens of C. botulinum Types A, B, E & F by Immunoproteomic Approach.
PMID:29332140
Role of N-glycosylation in activation of proMMP-9. A molecular dynamics simulations study.
PMID:29329315
The role of IL‑16 gene polymorphisms in endometriosis.
PMID:29328375
Antimicrobial peptide gene BdPho responds to peptidoglycan infection and mating stimulation in oriental fruit fly, Bactrocera dorsalis (Hendel).
PMID:29327267
Antibacterial Evaluation and Virtual Screening of New Thiazolyl-Triazole Schiff Bases as Potential DNA-Gyrase Inhibitors.
PMID:29324679
Expression of cry2Ah1 and two domain II mutants in transgenic tobacco confers high resistance to susceptible and Cry1Ac-resistant cotton bollworm.
PMID:29323243
Signaling ammonium across membranes through an ammonium sensor histidine kinase.
PMID:29323112
Evolution of the shut-off steps of vertebrate phototransduction.
PMID:29321241
Similar localization of conformational IgE epitopes on the house dust mite allergens Der p 5 and Der p 21 despite limited IgE cross-reactivity.
PMID:29319884
Multiple mutations and overexpression of the MdaE7 carboxylesterase gene associated with male-linked malathion resistance in housefly, Musca domestica (Diptera: Muscidae).
PMID:29317643
Tyrosine kinase inhibitor sensitive PDGFRΑ mutations in GIST: Two cases and review of the literature.
PMID:29312652
Structural analysis of mtEXO mitochondrial RNA degradosome reveals tight coupling of nuclease and helicase components.
PMID:29311576
Molecular mechanisms of cutis laxa- and distal renal tubular acidosis-causing mutations in V-ATPase a subunits, ATP6V0A2 and ATP6V0A4.
PMID:29311258
Structure and Function of Caltrin (Calcium Transport Inhibitor) Proteins.
PMID:29308010
Muscle-Specific Mis-Splicing and Heart Disease Exemplified by RBM20.
PMID:29304022
Systematic Identification of Lysine 2-hydroxyisobutyrylated Proteins in Proteus mirabilis.
PMID:29298837
A sparse autoencoder-based deep neural network for protein solvent accessibility and contact number prediction.
PMID:29297299
Structural and Immunological Characterization of Novel Recombinant MOMP-Based Chlamydial Antigens.
PMID:29295593
Structural Analysis and Epitope Prediction of MHC Class-1-Chain Related Protein-A for Cancer Vaccine Development.
PMID:29295563
Sodium taurocholate cotransporting polypeptide (NTCP) deficiency: Identification of a novel SLC10A1 mutation in two unrelated infants presenting with neonatal indirect hyperbilirubinemia and remarkable hypercholanemia.
PMID:29290974
Human oncoprotein Musashi-2 N-terminal RNA recognition motif backbone assignment and identification of RNA-binding pocket.
PMID:29290973
The gene product of a Trypanosoma equiperdum ortholog of the cAMP-dependent protein kinase regulatory subunit is a monomeric protein that is not capable of binding cyclic nucleotides.
PMID:29288679
Characterization of a novel variant in siblings with Asparagine Synthetase Deficiency.
PMID:29279279
Broadly neutralizing antiviral responses induced by a single-molecule HPV vaccine based on thermostable thioredoxin-L2 multiepitope nanoparticles.
PMID:29269879
A Single Mechanosensitive Channel Protects Francisella tularensis subsp. holarctica from Hypoosmotic Shock and Promotes Survival in the Aquatic Environment.
PMID:29269496
Ascorbic acid may not be involved in cryptochrome-based magnetoreception.
PMID:29263128
Peptide Uptake Is Essential for Borrelia burgdorferi Viability and Involves Structural and Regulatory Complexity of its Oligopeptide Transporter.
PMID:29259089
Structural, expression and evolutionary analysis of the non-specific phospholipase C gene family in Gossypium hirsutum.
PMID:29258435
Mapping genetic variations to three-dimensional protein structures to enhance variant interpretation: a proposed framework.
PMID:29254494
The amino-terminus of the hepatitis C virus (HCV) p7 viroporin and its cleavage from glycoprotein E2-p7 precursor determine specific infectivity and secretion levels of HCV particle types.
PMID:29253880
Chicken GRIFIN: Structural characterization in crystals and in solution.
PMID:29248541
Structural basis for lipid binding and mechanism of the Mycobacterium tuberculosis Rv3802 phospholipase.
PMID:29247008
A novel germline mutation (c.A527G) in STK11 gene causes Peutz-Jeghers syndrome in a Chinese girl: A case report.
PMID:29245219
Engineering thermal stability and solvent tolerance of the soluble quinoprotein PedE from Pseudomonas putida KT2440 with a heterologous whole-cell screening approach.
PMID:29239114
Redox-Sensing Under Hypochlorite Stress and Infection Conditions by the Rrf2-Family Repressor HypR in Staphylococcus aureus.
PMID:29237286
Structural and functional dissection of the DH and PH domains of oncogenic Bcr-Abl tyrosine kinase.
PMID:29235475
Evolution and Expansion of the Prokaryote-Like Lipoxygenase Family in the Brown Alga Saccharina japonica.
PMID:29234336
Acetylome of Acinetobacter baumannii SK17 Reveals a Highly-Conserved Modification of Histone-Like Protein HU.
PMID:29230394
Characterization of auxiliary iron-sulfur clusters in a radical S-adenosylmethionine enzyme PqqE from Methylobacterium extorquens AM1.
PMID:29226074
In Silico Validation of D7 Salivary Protein-derived B- and T-cell Epitopes of Aedes aegypti as Potential Vaccine to Prevent Transmission of Flaviviruses and Togaviruses to Humans.
PMID:29225429
Structural Dynamics of the MscL C-terminal Domain.
PMID:29222414
Diverse effects of distance cutoff and residue interval on the performance of distance-dependent atom-pair potential in protein structure prediction.
PMID:29221443
Prediction on the risk population of idiosyncratic adverse reactions based on molecular docking with mutant proteins.
PMID:29221149
The Neutralizing Linear Epitope of Human Herpesvirus 6A Glycoprotein B Does Not Affect Virus Infectivity.
PMID:29212944
Experimental Adaptive Evolution of Simian Immunodeficiency Virus SIVcpz to Pandemic Human Immunodeficiency Virus Type 1 by Using a Humanized Mouse Model.
PMID:29212937
Betanodavirus B2 protein triggers apoptosis and necroptosis in lung cancer cells that suppresses autophagy.
PMID:29212215
Allosteric Control of a Plant Receptor Kinase through S-Glutathionylation.
PMID:29211989
PvdO is required for the oxidation of dihydropyoverdine as the last step of fluorophore formation in Pseudomonas fluorescens.
PMID:29208656
In vivo tropism of Salmonella Typhi toxin to cells expressing a multiantennal glycan receptor.
PMID:29203881
In Vitro, In Silico, and In Vivo Analyses of Novel Aromatic Amidines against Trypanosoma cruzi.
PMID:29203486
Exposing the Molecular Screening Method of Indonesian Natural Products Derivate as Drug Candidates for Cervical Cancer.
PMID:29201098
Computationally-driven identification of antibody epitopes.
PMID:29199956
Conserved Lipid and Small-Molecule Modulation of COQ8 Reveals Regulation of the Ancient Kinase-like UbiB Family.
PMID:29198567
The P-type ATPase CtpG preferentially transports Cd2+ across the Mycobacterium tuberculosis plasma membrane.
PMID:29197950
Autopolysialylation of polysialyltransferases is required for polysialylation and polysialic acid chain elongation on select glycoprotein substrates.
PMID:29183999
Transition metal binding selectivity in proteins and its correlation with the phylogenomic classification of the cation diffusion facilitator protein family.
PMID:29180655
Continuous Automated Model EvaluatiOn (CAMEO) complementing the critical assessment of structure prediction in CASP12.
PMID:29178137
Characterization of an acetohydroxy acid synthase mutant conferring tolerance to imidazolinone herbicides in rice (Oryza sativa).
PMID:29170911
Cryo-EM structure of Saccharomyces cerevisiae target of rapamycin complex 2.
PMID:29170376
Planarian cholinesterase: molecular and functional characterization of an evolutionarily ancient enzyme to study organophosphorus pesticide toxicity.
PMID:29167930
Structure of human immunoproteasome with a reversible and noncompetitive inhibitor that selectively inhibits activated lymphocytes.
PMID:29167449
Characterization of the inner membrane protein BB0173 from Borrelia burgdorferi.
PMID:29166863
Identification and Initial Characterization of the Effectors of an Anther Smut Fungus and Potential Host Target Proteins.
PMID:29165363
Conserved Molecular Mechanism of TyrA Dehydrogenase Substrate Specificity Underlying Alternative Tyrosine Biosynthetic Pathways in Plants and Microbes.
PMID:29164132
Harnessing fungal nonribosomal cyclodepsipeptide synthetases for mechanistic insights and tailored engineering.
PMID:29163920
Human canonical CD157/Bst1 is an alternatively spliced isoform masking a previously unidentified primate-specific exon included in a novel transcript.
PMID:29162908
An orphan cbb3-type cytochrome oxidase subunit supports Pseudomonas aeruginosa biofilm growth and virulence.
PMID:29160206
Mapping tenascin-C interaction with toll-like receptor 4 reveals a new subset of endogenous inflammatory triggers.
PMID:29150600
Cry64Ba and Cry64Ca, Two ETX/MTX2-Type Bacillus thuringiensis Insecticidal Proteins Active against Hemipteran Pests.
PMID:29150505
Structural Basis of Mitochondrial Transcription Initiation.
PMID:29149603
A G3P[13] porcine group A rotavirus emerging in China is a reassortant and a natural recombinant in the VP4 gene.
PMID:29148270
Structure of FlgK reveals the divergence of the bacterial Hook-Filament Junction of Campylobacter.
PMID:29147015
Structural insights into Legionella RidL-Vps29 retromer subunit interaction reveal displacement of the regulator TBC1D5.
PMID:29146912
Localization and functional characterization of the p.Asn965Ser (N965S) ABCA4 variant in mice reveal pathogenic mechanisms underlying Stargardt macular degeneration.
PMID:29145636
Sanger sequencing in exonic regions of STK11 gene uncovers a novel de-novo germline mutation (c.962_963delCC) associated with Peutz-Jeghers syndrome and elevated cancer risk: case report of a Chinese patient.
PMID:29141581
Structure-function relationships in ABCG2: insights from molecular dynamics simulations and molecular docking studies.
PMID:29138424
Association of predicted pathogenic mutations in mitochondrial ND genes with distant metastasis in NSCLC and colon cancer.
PMID:29138417
Structural basis for antibody recognition of the NANP repeats in Plasmodium falciparum circumsporozoite protein.
PMID:29138320
KNOTTIN: the database of inhibitor cystine knot scaffold after 10 years, toward a systematic structure modeling.
PMID:29136213
Effect of two non-synonymous ecto-5'-nucleotidase variants on the genetic architecture of inosine 5'-monophosphate (IMP) and its degradation products in Japanese Black beef.
PMID:29132308
Unraveling the key to the resistance of canids to prion diseases.
PMID:29131852
OsMTP11 is localised at the Golgi and contributes to Mn tolerance.
PMID:29127328
Structural insight into activation of homoserine dehydrogenase from the archaeon Sulfolobus tokodaii via reduction.
PMID:29124164
Interaction of the Saccharomyces cerevisiae RING-domain protein Nse1 with Nse3 and the Smc5/6 complex is required for chromosome replication and stability.
PMID:29119272
The Kunitz Domain I of Hepatocyte Growth Factor Activator Inhibitor-2 Inhibits Matriptase Activity and Invasive Ability of Human Prostate Cancer Cells.
PMID:29118397
Selectivity analyses of γ-benzylidene digoxin derivatives to different Na,K-ATPase α isoforms: a molecular docking approach.
PMID:29115894
Structure and function of yeast Atg20, a sorting nexin that facilitates autophagy induction.
PMID:29114050
Structure-function analyses reveal key features in Staphylococcus aureus IsdB-associated unfolding of the heme-binding pocket of human hemoglobin.
PMID:29109153
Structure and function of a CE4 deacetylase isolated from a marine environment.
PMID:29107991
Prediction of Host-Pathogen Interactions for Helicobacter pylori by Interface Mimicry and Implications to Gastric Cancer.
PMID:29106933
Bioinformatics on a national scale: an example from Switzerland.
PMID:29106442
Enhancing the Thermostability of Rhizomucor miehei Lipase with a Limited Screening Library by Rational-Design Point Mutations and Disulfide Bonds.
PMID:29101200
Evolution of Single-Domain Globins in Hydrothermal Vent Scale-Worms.
PMID:29094190
Identification of a Critical and Conformational Neutralizing Epitope in Human Adenovirus Type 4 Hexon.
PMID:29093098
Discovery of the Membrane Binding Domain in Trifunctional Proline Utilization A.
PMID:29090935
Structures of transcription pre-initiation complex with TFIIH and Mediator.
PMID:29088706
Genome-wide identification and expression profile analysis of CCH gene family in Populus.
PMID:29085758
Proton-solute coupling mechanism of the maltose transporter from Saccharomyces cerevisiae.
PMID:29084970
Broadening the functionality of a J-protein/Hsp70 molecular chaperone system.
PMID:29084221
An intrinsically disordered linker controlling the formation and the stability of the bacterial flagellar hook.
PMID:29078764
Membrane alterations induced by nonstructural proteins of human norovirus.
PMID:29077760
Functional analyses of the CIF1-CIF2 complex in trypanosomes identify the structural motifs required for cytokinesis.
PMID:29074577
Assessment of protein assembly prediction in CASP12.
PMID:29071742
Tracing the Evolutionary History of the CAP Superfamily of Proteins Using Amino Acid Sequence Homology and Conservation of Splice Sites.
PMID:29071358
Assessment of vocation of rifabutin and rifapentine in replace of rifampcin in drug resistance leprosy patients: a molecular simulation study.
PMID:29071280
Structure, Immunogenicity, and Protective Mechanism of an Engineered Enterovirus 71-Like Particle Vaccine Mimicking 80S Empty Capsid.
PMID:29070691
The six metal binding domains in human copper transporter, ATP7B: molecular biophysics and disease-causing mutations.
PMID:29063292
Steered molecular dynamics simulation of the binding of the bovine auxilin J domain to the Hsc70 nucleotide-binding domain.
PMID:29063205
Structural and functional characterization of the Helicobacter pylori cytidine 5'-monophosphate-pseudaminic acid synthase PseF: molecular insight into substrate recognition and catalysis mechanism.
PMID:29062238
Cytolytic toxin production by Staphylococcus aureus is dependent upon the activity of the protoheme IX farnesyltransferase.
PMID:29062030
A Canonical Biotin Synthesis Enzyme, 8-Amino-7-Oxononanoate Synthase (BioF), Utilizes Different Acyl Chain Donors in Bacillus subtilis and Escherichia coli.
PMID:29054876
Enhanced biodegradation of mixed PAHs by mutated naphthalene 1,2-dioxygenase encoded by Pseudomonas putida strain KD6 isolated from petroleum refinery waste.
PMID:29051846
De novo mutations of TUBA3D are associated with keratoconus.
PMID:29051577
KIT performed as a driver gene candidate affecting the survival status of patients with stomach adenocarcinoma.
PMID:29050270
Structural prediction of two novel human atypical SLC transporters, MFSD4A and MFSD9, and their neuroanatomical distribution in mice.
PMID:29049335
Cox2A/Cox2B subunit interaction in Polytomella sp. cytochrome c oxidase: role of the Cox2B subunit extension.
PMID:29043530
A plasma proteomics method reveals links between ischemic stroke and MTHFR C677T genotype.
PMID:29042595
Transcription factor 19 interacts with histone 3 lysine 4 trimethylation and controls gluconeogenesis via the nucleosome-remodeling-deacetylase complex.
PMID:29042441
A cell-penetrating antibody inhibits human RAD51 via direct binding.
PMID:29036688
Plasmodium falciparum specific helicase 3 is nucleocytoplasmic protein and unwinds DNA duplex in 3' to 5' direction.
PMID:29030567
Investigating the bifunctionality of cyclizing and "classical" 5-aminolevulinate synthases.
PMID:29027286
A chemical and biological toolbox for Type Vd secretion: Characterization of the phospholipase A1 autotransporter FplA from Fusobacterium nucleatum.
PMID:29021252
Molecular Insights into the Potential Insecticidal Interaction of β-Dihydroagarofuran Derivatives with the H Subunit of V-ATPase.
PMID:29019960
A 23-Nucleotide Deletion in STK11 Gene Causes Peutz-Jeghers Syndrome and Malignancy in a Chinese Patient Without a Positive Family History.
PMID:28986664
Digging Deeper into CYP3A Testosterone Metabolism: Kinetic, Regioselectivity, and Stereoselectivity Differences between CYP3A4/5 and CYP3A7.
PMID:28986474
Novel CH1:CL interfaces that enhance correct light chain pairing in heterodimeric bispecific antibodies.
PMID:28981885
Computationally Optimized Broadly Reactive Hemagglutinin Elicits Hemagglutination Inhibition Antibodies against a Panel of H3N2 Influenza Virus Cocirculating Variants.
PMID:28978710
Cmr1 enables efficient RNA and DNA interference of a III-B CRISPR-Cas system by binding to target RNA and crRNA.
PMID:28977458
Heterologous Expression, Purification and Characterization of a Peroxidase Isolated from Lepidium draba.
PMID:28975545
TUBB4A mutations result in specific neuronal and oligodendrocytic defects that closely match clinically distinct phenotypes.
PMID:28973395
A unique cysteine-rich zinc finger domain present in a majority of class II ribonucleotide reductases mediates catalytic turnover.
PMID:28972190
A lower isoelectric point increases signal sequence-mediated secretion of recombinant proteins through a bacterial ABC transporter.
PMID:28972172
Substrate Specificity and Inhibitor Sensitivity of Plant UDP-Sugar Producing Pyrophosphorylases.
PMID:28970843
Biochemical efficacy, molecular docking and inhibitory effect of 2, 3-dimethylmaleic anhydride on insect acetylcholinesterase.
PMID:28970561
3.2-Å-resolution structure of the 90S preribosome before A1 pre-rRNA cleavage.
PMID:28967883
Folding Membrane Proteins by Deep Transfer Learning.
PMID:28957654
Functional significance of active site residues in the enzymatic component of the Clostridium difficile binary toxin.
PMID:28955942
The unusual substrate specificity of a virulence associated serine hydrolase from the highly toxic bacterium, Francisella tularensis.
PMID:28955933
Investigation of the key factors on 3-hydroxypropionic acid production with different recombinant strains.
PMID:28955611
Allosteric-activation mechanism of BK channel gating ring triggered by calcium ions.
PMID:28953901
A Novel Multifunctional β-N-Acetylhexosaminidase Revealed through Metagenomics of an Oil-Spilled Mangrove.
PMID:28952541
Novel compound heterozygous mutations in the GPR98 (USH2C) gene identified by whole exome sequencing in a Moroccan deaf family.
PMID:28951997
Structural Basis for EarP-Mediated Arginine Glycosylation of Translation Elongation Factor EF-P.
PMID:28951478
A single point mutation in a TssB/VipA homolog disrupts sheath formation in the type VI secretion system of Proteus mirabilis.
PMID:28949977
A two-step transport pathway allows the mother cell to nurture the developing spore in Bacillus subtilis.
PMID:28945739
Redox state-dependent modulation of plant SnRK1 kinase activity differs from AMPK regulation in animals.
PMID:28940407
Visualisation of a flexible modular structure of the ER folding-sensor enzyme UGGT.
PMID:28939828
Periodontal-induced chronic inflammation triggers macrophage secretion of Ccl12 to inhibit fibroblast-mediated cardiac wound healing.
PMID:28931761
DNA Ligase IV Guides End-Processing Choice during Nonhomologous End Joining.
PMID:28930678
Rethinking the Origin of Primates by Reconstructing Their Diel Activity Patterns Using Genetics and Morphology.
PMID:28928374
The periplasmic transaminase PtaA of Pseudomonas fluorescens converts the glutamic acid residue at the pyoverdine fluorophore to α-ketoglutaric acid.
PMID:28912270
Importance of the REM (Ras exchange) domain for membrane interactions by RasGRP3.
PMID:28912101
Structure-based domain assignment in Leishmania infantum EndoG: characterization of a pH-dependent regulatory switch and a C-terminal extension that largely dictates DNA substrate preferences.
PMID:28911117
Leukoencephalopathy-causing CLCN2 mutations are associated with impaired Cl- channel function and trafficking.
PMID:28905383
Structural and functional diversity arising from intra- and inter-haplotype combinations of duplicated DQA and B loci within the ovine MHC.
PMID:28889256
Lis1 Has Two Opposing Modes of Regulating Cytoplasmic Dynein.
PMID:28886386
Genomic Analysis of Terpene Synthase Family and Functional Characterization of Seven Sesquiterpene Synthases from Citrus sinensis.
PMID:28883829
Molecular modeling and structure-based drug discovery approach reveals protein kinases as off-targets for novel anticancer drug RH1.
PMID:28879492
Characteristics of 29 novel atypical solute carriers of major facilitator superfamily type: evolutionary conservation, predicted structure and neuronal co-expression.
PMID:28878041
Different Routes for Conifer- and Sinapaldehyde and Higher Saccharification upon Deficiency in the Dehydrogenase CAD1.
PMID:28878036
Crystal structures of a ZIP zinc transporter reveal a binuclear metal center in the transport pathway.
PMID:28875161
Modeling protein quaternary structure of homo- and hetero-oligomers beyond binary interactions by homology.
PMID:28874689
TRIM23 mediates virus-induced autophagy via activation of TBK1.
PMID:28871090
Vps13-Mcp1 interact at vacuole-mitochondria interfaces and bypass ER-mitochondria contact sites.
PMID:28864540
Pulling MscL open via N-terminal and TM1 helices: A computational study towards engineering an MscL nanovalve.
PMID:28859093
Developmentally Regulated GTP binding protein 1 (DRG1) controls microtubule dynamics.
PMID:28855639
The Treponema pallidum Outer Membrane.
PMID:28849315
TAF10 and TAF10b partially redundant roles during Drosophila melanogaster morphogenesis.
PMID:28841365
Modelling of microbial polyhydroxyalkanoate surface binding protein PhaP for rational mutagenesis.
PMID:28840964
In silico analysis of protein toxin and bacteriocins from Lactobacillus paracasei SD1 genome and available online databases.
PMID:28837656
One-domain CD4 Fused to Human Anti-CD16 Antibody Domain Mediates Effective Killing of HIV-1-Infected Cells.
PMID:28831040
The Non-Lantibiotic Bacteriocin Garvicin Q Targets Man-PTS in a Broad Spectrum of Sensitive Bacterial Genera.
PMID:28827688
Characterization of a novel class A carbapenemase PAD-1 from Paramesorhizobium desertii A-3-ET, a strain highly resistant to β-lactam antibiotics.
PMID:28827656
Curcumin liposomes interfere with quorum sensing system of Aeromonas sobria and in silico analysis.
PMID:28819178
Structural Mechanism for Modulation of Synaptic Neuroligin-Neurexin Signaling by MDGA Proteins.
PMID:28817804
Defining Electron Bifurcation in the Electron-Transferring Flavoprotein Family.
PMID:28808132
Activity of the β-Lactamase Inhibitor LN-1-255 against Carbapenem-Hydrolyzing Class D β-Lactamases from Acinetobacter baumannii.
PMID:28807908
Crystal Structure and Substrate Specificity Modification of Acetyl Xylan Esterase from Aspergillus luchuensis.
PMID:28802264
Molecular characterization of EcCIPK24 gene of finger millet (Eleusine coracana) for investigating its regulatory role in calcium transport.
PMID:28794922
A family of archaea-like carboxylesterases preferentially expressed in the symbiotic phase of the mychorrizal fungus Tuber melanosporum.
PMID:28794466
Structural Rearrangement upon Fragmentation of the Stability Core of the ALS-Linked Protein TDP-43.
PMID:28793209
Structural insights into the catalytic mechanism of a sacrificial sulfur insertase of the N-type ATP pyrophosphatase family, LarE.
PMID:28784764
Structure and application of antifreeze proteins from Antarctic bacteria.
PMID:28784139
An overview of comparative modelling and resources dedicated to large-scale modelling of genome sequences.
PMID:28777078
Insights into the role of 3-O-sulfotransferase in heparan sulfate biosynthesis.
PMID:28770943
Conformational and chemical selection by a trans-acting editing domain.
PMID:28768811
Molecular evolutionary patterns of NAD+/Sirtuin aging signaling pathway across taxa.
PMID:28767699
Bradyrhizobium elkanii nod regulon: insights through genomic analysis.
PMID:28767122
Microtubule-dependent ribosome localization in C. elegans neurons.
PMID:28767038
Impact of LCA-Associated E14L LRAT Mutation on Protein Stability and Retinoid Homeostasis.
PMID:28758396
Antivirals for allosteric inhibition of Zika virus using a homology model and experimentally determined structure of envelope protein.
PMID:28754167
Colorful Packages: Encapsulation of Fluorescent Proteins in Complex Coacervate Core Micelles.
PMID:28753915
New findings on phosphodiesterases, MoPdeH and MoPdeL, in Magnaporthe oryzae revealed by structural analysis.
PMID:28752677
Gene Expression and Molecular Characterization of a Xylanase from Chicken Cecum Metagenome.
PMID:28751915
Biochemical characterization of a new nicotinamidase from an unclassified bacterium thriving in a geothermal water stream microbial mat community.
PMID:28750065
Predictive Structure and Topology of Peroxisomal ATP-Binding Cassette (ABC) Transporters.
PMID:28737695
Multiomics analysis of the giant triton snail salivary gland, a crown-of-thorns starfish predator.
PMID:28729681
The whole-genome landscape of medulloblastoma subtypes.
PMID:28726821
Characterization of the cytochrome P450 monooxygenase genes (P450ome) from the carotenogenic yeast Xanthophyllomyces dendrorhous.
PMID:28724407
MAST-like protein kinase IREH1 from Arabidopsis thaliana co-localizes with the centrosome when expressed in animal cells.
PMID:28717875
Random mutagenesis analysis and identification of a novel C2H2-type transcription factor from the nematode-trapping fungus Arthrobotrys oligospora.
PMID:28717216
Biophysical investigation of type A PutAs reveals a conserved core oligomeric structure.
PMID:28710792
Rapid identification of genes controlling virulence and immunity in malaria parasites.
PMID:28704525
Biochemical characterization of aminopeptidase N2 from Toxoplasma gondii.
PMID:28701624
Identification, classification and transcriptional profiles of dirigent domain-containing proteins in sugarcane.
PMID:28699001
Crystal structure of the N-terminal domain of VqsR from Pseudomonas aeruginosa at 2.1 Å resolution.
PMID:28695853
Crystal structure of the UBR-box from UBR6/FBXO11 reveals domain swapping mediated by zinc binding.
PMID:28691247
Altered paracellular cation permeability due to a rare CLDN10B variant causes anhidrosis and kidney damage.
PMID:28686597
Structure and catalytic activation of the TRIM23 RING E3 ubiquitin ligase.
PMID:28681414
A channelopathy mutation in the voltage-sensor discloses contributions of a conserved phenylalanine to gating properties of Kv1.1 channels and ataxia.
PMID:28676720
Interactions between LHX3- and ISL1-family LIM-homeodomain transcription factors are conserved in Caenorhabditis elegans.
PMID:28676648
Generation of monoclonal pan-hemagglutinin antibodies for the quantification of multiple strains of influenza.
PMID:28662134
Hydrocinnamic Acid Inhibits the Currents of WT and SQT3 Syndrome-Related Mutants of Kir2.1 Channel.
PMID:28660286
Phylogeography of Coxsackievirus A16 Reveals Global Transmission Pathways and Recent Emergence and Spread of a Recombinant Genogroup.
PMID:28659474
Proton transfer reactions in the red light-activatable channelrhodopsin variant ReaChR and their relevance for its function.
PMID:28659342
Functional Role of Lanthanides in Enzymatic Activity and Transcriptional Regulation of Pyrroloquinoline Quinone-Dependent Alcohol Dehydrogenases in Pseudomonas putida KT2440.
PMID:28655819
Antibody against Microbial Neuraminidases Recognizes Human Sialidase 3 (NEU3): the Neuraminidase/Sialidase Superfamily Revisited.
PMID:28655817
The Structure of the R2TP Complex Defines a Platform for Recruiting Diverse Client Proteins to the HSP90 Molecular Chaperone System.
PMID:28648606
Structures and dynamics of hibernating ribosomes from Staphylococcus aureus mediated by intermolecular interactions of HPF.
PMID:28645916
Alpha-Mangostin Reverses Multidrug Resistance by Attenuating the Function of the Multidrug Resistance-Linked ABCG2 Transporter.
PMID:28641010
Mutations in human AID differentially affect its ability to deaminate cytidine and 5-methylcytidine in ssDNA substrates in vitro.
PMID:28634398
Exploration of binding and inhibition mechanism of a small molecule inhibitor of influenza virus H1N1 hemagglutinin by molecular dynamics simulation.
PMID:28630402
EV-3, an endogenous human erythropoietin isoform with distinct functional relevance.
PMID:28623280
Structural basis for the regulatory interactions of proapoptotic Par-4.
PMID:28622290
Ratchet-like polypeptide translocation mechanism of the AAA+ disaggregase Hsp104.
PMID:28619716
New adenovirus-based vaccine vectors targeting Pfs25 elicit antibodies that inhibit Plasmodium falciparum transmission.
PMID:28619071
A Conserved Leucine Zipper Motif in Gammaherpesvirus ORF52 Is Critical for Distinct Microtubule Rearrangements.
PMID:28615210
Spacer capture and integration by a type I-F Cas1-Cas2-3 CRISPR adaptation complex.
PMID:28611213
Novel Class IIa-Selective Histone Deacetylase Inhibitors Discovered Using an in Silico Virtual Screening Approach.
PMID:28607401
Zinc-dependent regulation of zinc import and export genes by Zur.
PMID:28598435
Structural insight into the role of Gln293Met mutation on the Peloruside A/Laulimalide association with αβ-tubulin from molecular dynamics simulations, binding free energy calculations and weak interactions analysis.
PMID:28597356
Alternative splicing of CNOT7 diversifies CCR4-NOT functions.
PMID:28591869
De novo non-synonymous TBL1XR1 mutation alters Wnt signaling activity.
PMID:28588275
Biochemical and Computational Insights on a Novel Acid-Resistant and Thermal-Stable Glucose 1-Dehydrogenase.
PMID:28587256
Engineering affinity agents for the detection of hemi-methylated CpG sites in DNA.
PMID:28580176
An Atlas of β-Glucuronidases in the Human Intestinal Microbiome.
PMID:28578872
Identification of diagnostic peptide regions that distinguish Zika virus from related mosquito-borne Flaviviruses.
PMID:28562637
Prokaryotic expression, purification and characterization of human cyclooxygenase-2.
PMID:28560423
Molecular dynamics simulations reveal the conformational dynamics of Arabidopsis thaliana BRI1 and BAK1 receptor-like kinases.
PMID:28559283
Structural Insights into TMB-1 and the Role of Residues 119 and 228 in Substrate and Inhibitor Binding.
PMID:28559248
Activation of Aedes aegypti prophenoloxidase-3 and its role in the immune response against entomopathogenic fungi.
PMID:28556276
Site-specific His/Asp phosphoproteomic analysis of prokaryotes reveals putative targets for drug resistance.
PMID:28545444
The LOTUS domain is a conserved DEAD-box RNA helicase regulator essential for the recruitment of Vasa to the germ plasm and nuage.
PMID:28536148
Evolution of an intricate J-protein network driving protein disaggregation in eukaryotes.
PMID:28504929
Design and Properties of Genetically Encoded Probes for Sensing Macromolecular Crowding.
PMID:28494963
Time-resolved dual transcriptomics reveal early induced Nicotiana benthamiana root genes and conserved infection-promoting Phytophthora palmivora effectors.
PMID:28494759
Acetyl group coordinated progression through the catalytic cycle of an arylalkylamine N-acetyltransferase.
PMID:28486510
Web3DMol: interactive protein structure visualization based on WebGL.
PMID:28482028
Molecular Mechanism of Substrate Processing by the Cdc48 ATPase Complex.
PMID:28475898
Structure and Dynamics of a 197 bp Nucleosome in Complex with Linker Histone H1.
PMID:28475873
Aromatic amino acids in the cellulose binding domain of Penicillium crustosum endoglucanase EGL1 differentially contribute to the cellulose affinity of the enzyme.
PMID:28475645
Structural Bases of Desensitization in AMPA Receptor-Auxiliary Subunit Complexes.
PMID:28472657
Fluoride export (FEX) proteins from fungi, plants and animals are 'single barreled' channels containing one functional and one vestigial ion pore.
PMID:28472134
Hypokalemia, hypomagnesemia, hypocalciuria, and recurrent tetany: Gitelman syndrome in a Chinese pedigree and literature review.
PMID:28469853
CRISPR-Cpf1 assisted genome editing of Corynebacterium glutamicum.
PMID:28469274
Dominant ER Stress-Inducing WFS1 Mutations Underlie a Genetic Syndrome of Neonatal/Infancy-Onset Diabetes, Congenital Sensorineural Deafness, and Congenital Cataracts.
PMID:28468959
Purification and characterization of a novel cold adapted fungal glucoamylase.
PMID:28464820
Structure and function of seed storage proteins in faba bean (Vicia faba L.).
PMID:28452019
Substrate selectivity of an isolated enoyl reductase catalytic domain from an iterative highly reducing fungal polyketide synthase reveals key components of programming.
PMID:28451251
Molecular fingerprinting of complex grass allergoids: size assessments reveal new insights in epitope repertoires and functional capacities.
PMID:28451054
SGNH hydrolase-type esterase domain containing Cbes-AcXE2: a novel and thermostable acetyl xylan esterase from Caldicellulosiruptor bescii.
PMID:28444450
Associations of maternal PLA2G4C and PLA2G4D polymorphisms with the risk of spontaneous preterm birth in a Chinese population.
PMID:28440406
Normal sleep requires the astrocyte brain-type fatty acid binding protein FABP7.
PMID:28435883
Computer-aided discovery of two novel chalcone-like compounds active and selective against Leishmania infantum.
PMID:28434763
The Lon protease-like domain in the bacterial RecA paralog RadA is required for DNA binding and repair.
PMID:28432121
Cloning retinoid and peroxisome proliferator-activated nuclear receptors of the Pacific oyster and in silico binding to environmental chemicals.
PMID:28426724
Invasion of Ancestral Mammals into Dim-light Environments Inferred from Adaptive Evolution of the Phototransduction Genes.
PMID:28425474
β-Carboxysome bioinformatics: identification and evolution of new bacterial microcompartment protein gene classes and core locus constraints.
PMID:28419380
Structural insights into type I and type II of nsp4 porcine reproductive and respiratory syndrome virus (nsp4 PRRSV) by molecular dynamics simulations.
PMID:28411461
Arabidopsis leucine-rich repeat receptor-like kinase NILR1 is required for induction of innate immunity to parasitic nematodes.
PMID:28406987
Subcellular Localization of Arabidopsis Pathogenesis-Related 1 (PR1) Protein.
PMID:28406455
Genetic resistance - an alternative for controlling PRRS?
PMID:28405453
GalaxyHomomer: a web server for protein homo-oligomer structure prediction from a monomer sequence or structure.
PMID:28387820
Substituted cysteine accessibility method (SCAM) analysis of the transport domain of human concentrative nucleoside transporter 3 (hCNT3) and other family members reveals features of structural and functional importance.
PMID:28385889
Cell Attachment Domains of the Porcine Epidemic Diarrhea Virus Spike Protein Are Key Targets of Neutralizing Antibodies.
PMID:28381581
Inclusion of an Arg-Gly-Asp receptor-recognition motif into the capsid protein of rabbit hemorrhagic disease virus enables culture of the virus in vitro.
PMID:28381555
N6-Substituted 5'-N-Methylcarbamoyl-4'-selenoadenosines as Potent and Selective A3 Adenosine Receptor Agonists with Unusual Sugar Puckering and Nucleobase Orientation.
PMID:28380296
Exome Sequencing Identified a Novel FBN2 Mutation in a Chinese Family with Congenital Contractural Arachnodactyly.
PMID:28379158
Bactericidal Permeability-Increasing Proteins Shape Host-Microbe Interactions.
PMID:28377525
SlpE is a calcium-dependent cytotoxic metalloprotease associated with clinical isolates of Serratia marcescens.
PMID:28366837
TMPL: a database of experimental and theoretical transmembrane protein models positioned in the lipid bilayer.
PMID:28365741
Allosteric modulation model of the mu opioid receptor by herkinorin, a potent not alkaloidal agonist.
PMID:28364251
Electrostatic attraction of weak monoacid anions increases probability for protonation and passage through aquaporins.
PMID:28360107
Homozygous p.(Glu87Lys) variant in ISCA1 is associated with a multiple mitochondrial dysfunctions syndrome.
PMID:28356563
Heterologous biosynthesis and manipulation of crocetin in Saccharomyces cerevisiae.
PMID:28356104
The toxicity of angiotensin converting enzyme inhibitors to larvae of the disease vectors Aedes aegypti and Anopheles gambiae.
PMID:28345667
Protein interaction evolution from promiscuity to specificity with reduced flexibility in an increasingly complex network.
PMID:28337996
Experimental recreation of the evolution of lignin-degrading enzymes from the Jurassic to date.
PMID:28331543
Epigallocatechin Gallate Inhibits Macaque SEVI-Mediated Enhancement of SIV or SHIV Infection.
PMID:28328549
Structure-based functional annotation of hypothetical proteins from Candida dubliniensis: a quest for potential drug targets.
PMID:28324558
Negative allosteric regulation of Enterococcus faecalis small alarmone synthetase RelQ by single-stranded RNA.
PMID:28320944
Novel fimbrilin PGN_1808 in Porphyromonas gingivalis.
PMID:28296909
Antagonizing effects of membrane-acting androgens on the eicosanoid receptor OXER1 in prostate cancer.
PMID:28290516
Role and convergent evolution of competing RNA secondary structures in mutually exclusive splicing.
PMID:28277933
Computational Modeling of complete HOXB13 protein for predicting the functional effect of SNPs and the associated role in hereditary prostate cancer.
PMID:28272408
An Eight-Residue Deletion in Escherichia coli FabG Causes Temperature-Sensitive Growth and Lipid Synthesis Plus Resistance to the Calmodulin Inhibitor Trifluoperazine.
PMID:28264990
Structural Alteration of OmpR as a Source of Ertapenem Resistance in a CTX-M-15-Producing Escherichia coli O25b:H4 Sequence Type 131 Clinical Isolate.
PMID:28264855
Comparative visualization of protein secondary structures.
PMID:28251875
The Arabidopsis O-fucosyltransferase SPINDLY activates nuclear growth repressor DELLA.
PMID:28244988
Molecular architecture of the 90S small subunit pre-ribosome.
PMID:28244370
The Echinococcus canadensis (G7) genome: a key knowledge of parasitic platyhelminth human diseases.
PMID:28241794
Experimental Evolution of Escherichia coli Harboring an Ancient Translation Protein.
PMID:28233029
Bioinformatic Analysis Reveals Archaeal tRNATyr and tRNATrp Identities in Bacteria.
PMID:28230768
A hydrophobic patch surrounding Trp154 in human neuroserpin controls the helix F dynamics with implications in inhibition and aggregation.
PMID:28230174
A Novel Mutation in the Pyrin Domain of the NOD-like Receptor Family Pyrin Domain Containing Protein 3 in Muckle-Wells Syndrome.
PMID:28229991
Anaplasma phagocytophilum Infection Subverts Carbohydrate Metabolic Pathways in the Tick Vector, Ixodes scapularis.
PMID:28229048
Proteasome Activity Profiling Uncovers Alteration of Catalytic β2 and β5 Subunits of the Stress-Induced Proteasome during Salinity Stress in Tomato Roots.
PMID:28217134
Ketoacylsynthase Domains of a Polyunsaturated Fatty Acid Synthase in Thraustochytrium sp. Strain ATCC 26185 Can Effectively Function as Stand-Alone Enzymes in Escherichia coli.
PMID:28213537
Involvement of three putative glucosyltransferases from the UGT72 family in flavonol glucoside/rhamnoside biosynthesis in Lotus japonicus seeds.
PMID:28204516
Structural basis of Mcm2-7 replicative helicase loading by ORC-Cdc6 and Cdt1.
PMID:28191893
SEPIa, a knowledge-driven algorithm for predicting conformational B-cell epitopes from the amino acid sequence.
PMID:28183272
Involvement of β-defensin 130 (DEFB130) in the macrophage microbicidal mechanisms for killing Plasmodium falciparum.
PMID:28181499
Kinetics, subcellular localization, and contribution to parasite virulence of a Trypanosoma cruzi hybrid type A heme peroxidase (TcAPx-CcP).
PMID:28179568
Identification of Novel Functions for Hepatitis C Virus Envelope Glycoprotein E1 in Virus Entry and Assembly.
PMID:28179528
Nidovirus RNA polymerases: Complex enzymes handling exceptional RNA genomes.
PMID:28174054
The structurally disordered paramyxovirus nucleocapsid protein tail domain is a regulator of the mRNA transcription gradient.
PMID:28168220
Two Novel Fungal Phenolic UDP Glycosyltransferases from Absidia coerulea and Rhizopus japonicus.
PMID:28159792
Molecular modeling of NK-CT1, from Indian monocellate cobra (Naja kaouthia) and its docking interaction with human DNA topoisomerase II alpha.
PMID:28149043
Allelic Polymorphism Determines Surface Expression or Intracellular Retention of the Human NK Cell Receptor KIR2DL5A (CD158f).
PMID:28144240
Ruxolitinib reverses dysregulated T helper cell responses and controls autoimmunity caused by a novel signal transducer and activator of transcription 1 (STAT1) gain-of-function mutation.
PMID:28139313
Short stature and hypoparathyroidism in a child with Kenny-Caffey syndrome type 2 due to a novel mutation in FAM111A gene.
PMID:28138333
Genomic and structural investigation on dolphin morbillivirus (DMV) in Mediterranean fin whales (Balaenoptera physalus).
PMID:28134317
GRIN3B missense mutation as an inherited risk factor for schizophrenia: whole-exome sequencing in a family with a familiar history of psychotic disorders.
PMID:28132660
The IDL of E. coli SSB links ssDNA and protein binding by mediating protein-protein interactions.
PMID:28127816
STAC3 stably interacts through its C1 domain with CaV1.1 in skeletal muscle triads.
PMID:28112192
Design, Synthesis and Antifungal Activity Evaluation of New Thiazolin-4-ones as Potential Lanosterol 14α-Demethylase Inhibitors.
PMID:28106743
Homology modeling and molecular dynamics provide structural insights into tospovirus nucleoprotein.
PMID:28105914
Construction of a novel lipolytic fusion biocatalyst GDEst-lip for industrial application.
PMID:28105534
Molecular Characterization of Nippostrongylus brasiliensis (Nematoda: Heligmosomatidae) from Mus musculus in India.
PMID:28095659
Structures of the Human HCN1 Hyperpolarization-Activated Channel.
PMID:28086084
SSB and the RecG DNA helicase: an intimate association to rescue a stalled replication fork.
PMID:28078722
Structural basis of co-translational quality control by ArfA and RF2 bound to ribosome.
PMID:28077875
Structure of a spliceosome remodelled for exon ligation.
PMID:28076345
Biochemical and Structural Insights into a Novel Thermostable β-1,3-Galactosidase from Marinomonas sp. BSi20414.
PMID:28075353
A Genomic and Protein-Protein Interaction Analyses of Nonsyndromic Hearing Impairment in Cameroon Using Targeted Genomic Enrichment and Massively Parallel Sequencing.
PMID:28075205
O-GlcNAcylation of STAT5 controls tyrosine phosphorylation and oncogenic transcription in STAT5-dependent malignancies.
PMID:28074064
Molecular and structural characteristics of multidrug resistance-associated protein 7 in Chinese liver fluke Clonorchis sinensis.
PMID:28058535
Characterization of the Porphyromonas gingivalis Type IX Secretion Trans-envelope PorKLMNP Core Complex.
PMID:28057754
Accurate De Novo Prediction of Protein Contact Map by Ultra-Deep Learning Model.
PMID:28056090
The 24th annual Nucleic Acids Research database issue: a look back and upcoming changes.
PMID:28053160
Identification and population history of CYP4V2 mutations in patients with Bietti crystalline corneoretinal dystrophy.
PMID:28051075
Difference in NaCl tolerance of membrane-bound 5'-nucleotidases purified from deep-sea and brackish water Shewanella species.
PMID:28050644
Widespread Historical Contingency in Influenza Viruses.
PMID:28049709
Cleavage of DFNA5 by caspase-3 during apoptosis mediates progression to secondary necrotic/pyroptotic cell death.
PMID:28045099
Regulation of XIAP Turnover Reveals a Role for USP11 in Promotion of Tumorigenesis.
PMID:28040451
SDH6 and SDH7 Contribute to Anchoring Succinate Dehydrogenase to the Inner Mitochondrial Membrane in Arabidopsis thaliana.
PMID:28039307
Autographa californica Multiple Nucleopolyhedrovirus AC83 is a Per Os Infectivity Factor (PIF) Protein Required for Occlusion-Derived Virus (ODV) and Budded Virus Nucleocapsid Assembly as well as Assembly of the PIF Complex in ODV Envelopes.
PMID:28031365
Human Neuronal Calcium Sensor-1 Protein Avoids Histidine Residues To Decrease pH Sensitivity.
PMID:28030949
Redox Balance in Lactobacillus reuteri DSM20016: Roles of Iron-Dependent Alcohol Dehydrogenases in Glucose/ Glycerol Metabolism.
PMID:28030590
Combined Whole-Cell High-Throughput Functional Screening for Identification of New Nicotinamidases/Pyrazinamidases in Metagenomic/Polygenomic Libraries.
PMID:28018295
Selective evolution of Toll-like receptors 3, 7, 8, and 9 in bats.
PMID:28013457
High affinity binding of the peptide agonist TIP-39 to the parathyroid hormone 2 (PTH2) receptor requires the hydroxyl group of Tyr-318 on transmembrane helix 5.
PMID:28012961
The ferredoxin-dependent glutamate synthase (OsFd-GOGAT) participates in leaf senescence and the nitrogen remobilization in rice.
PMID:28012016
The DE and FG loops of the HPV major capsid protein contribute to the epitopes of vaccine-induced cross-neutralising antibodies.
PMID:28004837
Contribution of target alteration, protection and efflux pump in achieving high ciprofloxacin resistance in Enterobacteriaceae.
PMID:28004362
Angucycline antibiotic waldiomycin recognizes common structural motif conserved in bacterial histidine kinases.
PMID:27999439
Trimeric gp120-specific bovine monoclonal antibodies require cysteine and aromatic residues in CDRH3 for high affinity binding to HIV Env.
PMID:27996375
Stabilization of Nucleotide Binding Domain Dimers Rescues ABCC6 Mutants Associated with Pseudoxanthoma Elasticum.
PMID:27994049
Conserved ABC Transport System Regulated by the General Stress Response Pathways of Alpha- and Gammaproteobacteria.
PMID:27994018
The biosynthetic pathway of 2-azahypoxanthine in fairy-ring forming fungus.
PMID:27991529
Metagenomic mining for thermostable esterolytic enzymes uncovers a new family of bacterial esterases.
PMID:27991516
Functional Analysis of the Fusarielin Biosynthetic Gene Cluster.
PMID:27983606
The Novel Membrane-Bound Proteins MFSD1 and MFSD3 are Putative SLC Transporters Affected by Altered Nutrient Intake.
PMID:27981419
Characterization of an Immunodominant Epitope in the Endodomain of the Coronavirus Membrane Protein.
PMID:27973413
Structural Basis for Regulation and Specificity of Fructooligosaccharide Import in Streptococcus pneumoniae.
PMID:27939783
Functional and structural characterization of a novel putative cysteine protease cell wall-modifying multi-domain enzyme selected from a microbial metagenome.
PMID:27934875
Oligomerization and chaperone-like activity of Drosophila melanogaster small heat shock protein DmHsp27 and three arginine mutants in the alpha-crystallin domain.
PMID:27933579
Systematic site-directed mutagenesis of the Helicobacter pylori CagL protein of the Cag type IV secretion system identifies novel functional domains.
PMID:27922023
Malate Synthase and β-Methylmalyl Coenzyme A Lyase Reactions in the Methylaspartate Cycle in Haloarcula hispanica.
PMID:27920298
The Streptococcus gordonii Adhesin CshA Protein Binds Host Fibronectin via a Catch-Clamp Mechanism.
PMID:27920201
New Insights into Molecular Organization of Human Neuraminidase-1: Transmembrane Topology and Dimerization Ability.
PMID:27917893
A Venom Serpin Splicing Isoform of the Endoparasitoid Wasp Pteromalus puparum Suppresses Host Prophenoloxidase Cascade by Forming Complexes with Host Hemolymph Proteinases.
PMID:27913622
Structure of the 70S ribosome from human pathogen Staphylococcus aureus.
PMID:27906650
De Novo Pyrimidine Biosynthesis Connects Cell Integrity to Amphotericin B Susceptibility in Cryptococcus neoformans.
PMID:27904878
In silico analysis of surface structure variation of PCV2 capsid resulting from loop mutations of its capsid protein (Cap).
PMID:27902320
The SWISS-MODEL Repository-new features and functionality.
PMID:27899672
Interaction of the cotranslational Hsp70 Ssb with ribosomal proteins and rRNA depends on its lid domain.
PMID:27882919
Structure of protein O-mannose kinase reveals a unique active site architecture.
PMID:27879205
Mechanism of cargo-directed Atg8 conjugation during selective autophagy.
PMID:27879200
Computer-Aided Drug Design Methods.
PMID:27873247
Molecular architecture of the yeast Elongator complex reveals an unexpected asymmetric subunit arrangement.
PMID:27872205
Structure of the transmembrane domain of HIV-1 envelope glycoprotein.
PMID:27868386
Integration of ruxolitinib into dose-intensified therapy targeted against a novel JAK2 F694L mutation in B-precursor acute lymphoblastic leukemia.
PMID:27860260
PRIMO: An Interactive Homology Modeling Pipeline.
PMID:27855192
Bioinformatics and Drug Discovery.
PMID:27848897
Crystal Structure and Conformational Change Mechanism of a Bacterial Nramp-Family Divalent Metal Transporter.
PMID:27839948
The tale of SSB.
PMID:27838363
Insights from molecular structure predictions of the infectious bronchitis virus S1 spike glycoprotein.
PMID:27836775
Differences in amino acid frequency in CagA and VacA sequences of Helicobacter pylori distinguish gastric cancer from gastric MALT lymphoma.
PMID:27833662
Drosophila Enhancer of Rudimentary Homolog, ERH, Is a Binding Partner of RPS3, RPL19, and DDIT4, Suggesting a Mechanism for the Nuclear Localization of ERH.
PMID:27830090
Replicated Risk Nicotinic Cholinergic Receptor Genes for Nicotine Dependence.
PMID:27827986
Cloning and expression of SgCYP450-4 from Siraitia grosvenorii.
PMID:27818929
Structural Prediction and In Silico Physicochemical Characterization for Mouse Caltrin I and Bovine Caltrin Proteins.
PMID:27812283
Complete structure of the bacterial flagellar hook reveals extensive set of stabilizing interactions.
PMID:27811912
CD72 negatively regulates B lymphocyte responses to the lupus-related endogenous toll-like receptor 7 ligand Sm/RNP.
PMID:27810925
Structural Insights into the Drosophila melanogaster Retinol Dehydrogenase, a Member of the Short-Chain Dehydrogenase/Reductase Family.
PMID:27809489
Exploring Human Diseases and Biological Mechanisms by Protein Structure Prediction and Modeling.
PMID:27807743
Looking for inhibitors of the dengue virus NS5 RNA-dependent RNA-polymerase using a molecular docking approach.
PMID:27784988
GPCR and IR genes in Schistosoma mansoni miracidia.
PMID:27784323
NPAS1-ARNT and NPAS3-ARNT crystal structures implicate the bHLH-PAS family as multi-ligand binding transcription factors.
PMID:27782878
Structural Stability, Transitions, and Interactions within SoxYZCD-Thiosulphate from Sulfurimonas denitrificans: An In Silico Molecular Outlook for Maintaining Environmental Sulphur Cycle.
PMID:27777586
Genome-Wide Analysis, Classification, Evolution, and Expression Analysis of the Cytochrome P450 93 Family in Land Plants.
PMID:27760179
Characterization of Triticum aestivum Abscisic Acid Receptors and a Possible Role for These in Mediating Fusairum Head Blight Susceptibility in Wheat.
PMID:27755583
Nanomechanical properties of MscL α helices: A steered molecular dynamics study.
PMID:27753526
Structural characterization of the circadian clock protein complex composed of KaiB and KaiC by inverse contrast-matching small-angle neutron scattering.
PMID:27752127
Barley Yellow Mosaic Virus VPg Is the Determinant Protein for Breaking eIF4E-Mediated Recessive Resistance in Barley Plants.
PMID:27746794
Cryo-EM Structure of Caspase-8 Tandem DED Filament Reveals Assembly and Regulation Mechanisms of the Death-Inducing Signaling Complex.
PMID:27746017
Identification of the critical residues responsible for differential reactivation of the triosephosphate isomerases of two trypanosomes.
PMID:27733588
The C-terminal dimerization motif of cyclase-associated protein is essential for actin monomer regulation.
PMID:27729544
SARAH Domain-Mediated MST2-RASSF Dimeric Interactions.
PMID:27716844
Identification of high-affinity anti-CD16A allotype-independent human antibody domains.
PMID:27712994
Broad phylogeny and functionality of cellulosomal components in the bovine rumen microbiome.
PMID:27712009
A chimeric protein-based malaria vaccine candidate induces robust T cell responses against Plasmodium vivax MSP119.
PMID:27708348
The Architecture of Trypanosoma brucei editosomes.
PMID:27708162
Metabolomics and Cheminformatics Analysis of Antifungal Function of Plant Metabolites.
PMID:27706030
Stargazin Modulation of AMPA Receptors.
PMID:27705782
Structure of myosin filaments from relaxed Lethocerus flight muscle by cryo-EM at 6 Å resolution.
PMID:27704041
PvdN Enzyme Catalyzes a Periplasmic Pyoverdine Modification.
PMID:27703013
Ohgata, the Single Drosophila Ortholog of Human Cereblon, Regulates Insulin Signaling-dependent Organismic Growth.
PMID:27702999
Three pairs of weak interactions precisely regulate the G-loop gate of Kir2.1 channel.
PMID:27699887
X-ray structure of the human α4β2 nicotinic receptor.
PMID:27698419
Cofactors-loaded quaternary structure of lysine-specific demethylase 5C (KDM5C) protein: Computational model.
PMID:27696497
Redox-assisted regulation of Ca2+ homeostasis in the endoplasmic reticulum by disulfide reductase ERdj5.
PMID:27694578
APSA Awardee Submission: Tumor/cancer stem cell marker doublecortin-like kinase 1 in liver diseases.
PMID:27694285
Characterization of Two Monoclonal Antibodies That Recognize Linker Region and Carboxyl Terminal Domain of Coronavirus Nucleocapsid Protein.
PMID:27689694
An Approach for Zika Virus Inhibition Using Homology Structure of the Envelope Protein.
PMID:27683255
Rapid Electron Transfer within the III-IV Supercomplex in Corynebacterium glutamicum.
PMID:27682138
Structural and Functional Characterization of a Ruminal β-Glycosidase Defines a Novel Subfamily of Glycoside Hydrolase Family 3 with Permuted Domain Topology.
PMID:27679487
Selective activation of vascular Kv 7.4/Kv 7.5 K+ channels by fasudil contributes to its vasorelaxant effect.
PMID:27677924
Data set for phylogenetic tree and RAMPAGE Ramachandran plot analysis of SODs in Gossypium raimondii and G. arboreum.
PMID:27672674
Protein sequences bound to mineral surfaces persist into deep time.
PMID:27668515
Induction of anti-EGFR immune response with mimotopes identified from a phage display peptide library by panitumumab.
PMID:27659529
Clinically Significant Unclassified Variants in BRCA1 and BRCA2 genes among Korean Breast Cancer Patients.
PMID:27658390
The Effectiveness of Natural Diarylheptanoids against Trypanosoma cruzi: Cytotoxicity, Ultrastructural Alterations and Molecular Modeling Studies.
PMID:27658305
The Protective Effect against Extracellular Histones Afforded by Long-Pentraxin PTX3 as a Regulator of NETs.
PMID:27656184
modPDZpep: a web resource for structure based analysis of human PDZ-mediated interaction networks.
PMID:27655048
Cyclic di-GMP mediates a histidine kinase/phosphatase switch by noncovalent domain cross-linking.
PMID:27652341
Structural basis for disruption of claudin assembly in tight junctions by an enterotoxin.
PMID:27647526
Cloning, expression, and characterization of a peptidoglycan hydrolase from the Burkholderia pseudomallei phage ST79.
PMID:27637947
Organization, Function, and Therapeutic Targeting of the Morbillivirus RNA-Dependent RNA Polymerase Complex.
PMID:27626440
Protein Carbonylation of an Amino Acid Residue of the Na/K-ATPase α1 Subunit Determines Na/K-ATPase Signaling and Sodium Transport in Renal Proximal Tubular Cells.
PMID:27613772
The genome of the largest bony fish, ocean sunfish (Mola mola), provides insights into its fast growth rate.
PMID:27609345
Diversity-oriented synthesis yields novel multistage antimalarial inhibitors.
PMID:27602946
PCP-B class pollen coat proteins are key regulators of the hydration checkpoint in Arabidopsis thaliana pollen-stigma interactions.
PMID:27596924
Atomic structure of the entire mammalian mitochondrial complex I.
PMID:27595392
HSAF-induced antifungal effects in Candida albicans through ROS-mediated apoptosis.
PMID:27594989
Discovery of Novel Bacterial Cell-Penetrating Phylloseptins in Defensive Skin Secretions of the South American Hylid Frogs, Phyllomedusa duellmani and Phyllomedusa coelestis.
PMID:27589802
OCT4 spliced variants are highly expressed in brain cancer tissues and inhibition of OCT4B1 causes G2/M arrest in brain cancer cells.
PMID:27585657
The CXCL8-CXCR1/2 pathways in cancer.
PMID:27578214
Genomic Analyses of Cladophialophora bantiana, a Major Cause of Cerebral Phaeohyphomycosis Provides Insight into Its Lifestyle, Virulence and Adaption in Host.
PMID:27570972
In silico studies of the interaction between BRN2 protein and MORE DNA.
PMID:27568376
Immobilization of LccC Laccase from Aspergillus nidulans on Hard Surfaces via Fungal Hydrophobins.
PMID:27565614
Molecular and immunological characterization of cathepsin L-like cysteine protease of Paragonimus pseudoheterotremus.
PMID:27562899
Corynebacterium diphtheriae HmuT: dissecting the roles of conserved residues in heme pocket stabilization.
PMID:27561288
Molecular cloning and characterization of a novel freezing-inducible DREB1/CBF transcription factor gene in boreal plant Iceland poppy (Papaver nudicaule).
PMID:27560992
A Family of Negative Regulators Targets the Committed Step of de Novo Fatty Acid Biosynthesis.
PMID:27559025
High-specificity synthesis of novel monomers by remodeled alcohol hydroxylase.
PMID:27557638
A mutagenic study identifying critical residues for the structure and function of rice manganese transporter OsMTP8.1.
PMID:27555514
A functional BH3 domain in an aquaporin from Leishmania infantum.
PMID:27551533
Disease-Homologous Mutation in the Cation Diffusion Facilitator Protein MamM Causes Single-Domain Structural Loss and Signifies Its Importance.
PMID:27550551
Peptides from American alligator plasma are antimicrobial against multi-drug resistant bacterial pathogens including Acinetobacter baumannii.
PMID:27542832
High-throughput screening for the identification of small-molecule inhibitors of the flaviviral protease.
PMID:27539384
Structural photoactivation of a full-length bacterial phytochrome.
PMID:27536728
Differential Roles for VviGST1, VviGST3, and VviGST4 in Proanthocyanidin and Anthocyanin Transport in Vitis vinífera.
PMID:27536314
An Alkaline Protease from Bacillus pumilus MP 27: Functional Analysis of Its Binding Model toward Its Applications As Detergent Additive.
PMID:27536284
Structural conservation in the template/pseudoknot domain of vertebrate telomerase RNA from teleost fish to human.
PMID:27531956
Ultra-dense SNP genetic map construction and identification of SiDt gene controlling the determinate growth habit in Sesamum indicum L.
PMID:27527492
Mapping N-linked glycosylation of carbohydrate-active enzymes in the secretome of Aspergillus nidulans grown on lignocellulose.
PMID:27508003
Molecular Characterization of the 14-3-3 Gene Family in Brachypodium distachyon L. Reveals High Evolutionary Conservation and Diverse Responses to Abiotic Stresses.
PMID:27507982
Conformational dynamics of cancer-associated MyD88-TIR domain mutant L252P (L265P) allosterically tilts the landscape toward homo-dimerization.
PMID:27503954
Adaptive evolution of virus-sensing toll-like receptor 8 in bats.
PMID:27502317
The structural basis of the dominant negative phenotype of the Gαi1β1γ2 G203A/A326S heterotrimer.
PMID:27498775
Microscopic Characterization of Membrane Transporter Function by In Silico Modeling and Simulation.
PMID:27497175
The Lp_3561 and Lp_3562 Enzymes Support a Functional Divergence Process in the Lipase/Esterase Toolkit from Lactobacillus plantarum.
PMID:27486450
Comparative and evolutionary analysis of α-amylase gene across monocots and dicots.
PMID:27481351
Spiral architecture of the Hsp104 disaggregase reveals the basis for polypeptide translocation.
PMID:27478928
Whole genome sequencing identifies ANXA3 and MTHFR mutations in a large family with an unknown equinus deformity associated genetic disorder.
PMID:27475959
Diaphragmatic Eventration in Sisters with Asparagine Synthetase Deficiency: A Novel Homozygous ASNS Mutation and Expanded Phenotype.
PMID:27469131
Validation of a multi-omics strategy for prioritizing personalized candidate driver genes.
PMID:27469031
The 3-D Structural Basis for the Pgi Genotypic Differences in the Performance of the Butterfly Melitaea cinxia at Different Temperatures.
PMID:27462709
Cryo-EM structure of the spliceosome immediately after branching.
PMID:27459055
Functional analysis of rare variants found in schizophrenia implicates a critical role for GIT1-PAK3 signaling in neuroplasticity.
PMID:27457813
Co-evolution of SNF spliceosomal proteins with their RNA targets in trans-splicing nematodes.
PMID:27450547
The matrix gene of influenza A H5N1 in Egypt, 2006-2016: molecular insights and distribution of amantadine-resistant variants.
PMID:27448682
Neisserial Opa Protein-CEACAM Interactions: Competition for Receptors as a Means of Bacterial Invasion and Pathogenesis.
PMID:27442026
Structural study of the G57W mutant of human gamma-S-crystallin, associated with congenital cataract.
PMID:27440995
EctD-mediated biotransformation of the chemical chaperone ectoine into hydroxyectoine and its mechanosensitive channel-independent excretion.
PMID:27439307
Reciprocal genomic evolution in the ant-fungus agricultural symbiosis.
PMID:27436133
Lupin Peptides Modulate the Protein-Protein Interaction of PCSK9 with the Low Density Lipoprotein Receptor in HepG2 Cells.
PMID:27424515
Amyotrophic Lateral Sclerosis Type 20 - In Silico Analysis and Molecular Dynamics Simulation of hnRNPA1.
PMID:27414033
Osmoadaptative Strategy and Its Molecular Signature in Obligately Halophilic Heterotrophic Protists.
PMID:27412608
Functional conservation and diversification of the soybean maturity gene E1 and its homologs in legumes.
PMID:27405888
Genomic characterization of plant cell wall degrading enzymes and in silico analysis of xylanases and polygalacturonases of Fusarium virguliforme.
PMID:27405320
Insights into Brain Glycogen Metabolism: THE STRUCTURE OF HUMAN BRAIN GLYCOGEN PHOSPHORYLASE.
PMID:27402852
Identification, Functional Characterization and Regulon Prediction of a Novel Two Component System Comprising BAS0540-BAS0541 of Bacillus anthracis.
PMID:27392063
Exome sequencing identifies highly recurrent somatic GATA2 and CEBPA mutations in acute erythroid leukemia.
PMID:27389056
Discovery of new cellulases from the metagenome by a metagenomics-guided strategy.
PMID:27382415
Reconstruction of the High-Osmolarity Glycerol (HOG) Signaling Pathway from the Halophilic Fungus Wallemia ichthyophaga in Saccharomyces cerevisiae.
PMID:27379041
Germline viral "fossils" guide in silico reconstruction of a mid-Cenozoic era marsupial adeno-associated virus.
PMID:27377618
The Sam68 nuclear body is composed of two RNase-sensitive substructures joined by the adaptor HNRNPL.
PMID:27377249
Alteramide B is a microtubule antagonist of inhibiting Candida albicans.
PMID:27373684
Structural Features and Functional Dependency on β-Clamp Define Distinct Subfamilies of Bacterial Mismatch Repair Endonuclease MutL.
PMID:27369079
Elucidation of AMPA receptor-stargazin complexes by cryo-electron microscopy.
PMID:27365450
Three duplication events and variable molecular evolution characteristics involved in multiple GGPS genes of six Solanaceae species.
PMID:27350691
Nipah virus matrix protein: expert hacker of cellular machines.
PMID:27350027
ICP35 Is a TREX-Like Protein Identified in White Spot Syndrome Virus.
PMID:27348862
Structural basis of potent Zika-dengue virus antibody cross-neutralization.
PMID:27338953
A study of the mutational landscape of pediatric-type follicular lymphoma and pediatric nodal marginal zone lymphoma.
PMID:27338637
Molecular Cloning of HbPR-1 Gene from Rubber Tree, Expression of HbPR-1 Gene in Nicotiana benthamiana and Its Inhibition of Phytophthora palmivora.
PMID:27337148
Cloning, molecular characterization, and expression analysis of the unc45 myosin chaperone b(unc45b)gene of grass carp (Ctenopharyngodon idellus).
PMID:27334505
The role of MscL amphipathic N terminus indicates a blueprint for bilayer-mediated gating of mechanosensitive channels.
PMID:27329693
Structure-based virtual screening of hypothetical inhibitors of the enzyme longiborneol synthase-a potential target to reduce Fusarium head blight disease.
PMID:27324634
Heparanase Activates Antithrombin through the Binding to Its Heparin Binding Site.
PMID:27322195
Crystal structure of linoleate 13R-manganese lipoxygenase in complex with an adhesion protein.
PMID:27313058
Molecular classification based on apomorphic amino acids (Arthropoda, Hexapoda): Integrative taxonomy in the era of phylogenomics.
PMID:27312960
Predicting Zika virus structural biology: Challenges and opportunities for intervention.
PMID:27296393
Genome sequence of Perigonia lusca single nucleopolyhedrovirus: insights into the evolution of a nucleotide metabolism enzyme in the family Baculoviridae.
PMID:27273152
Horizontal gene transfer events reshape the global landscape of arm race between viruses and homo sapiens.
PMID:27270140
Systematic Targeting of Protein-Protein Interactions.
PMID:27267699
Structure and mechanism of assembly line polyketide synthases.
PMID:27266330
Plasmodium falciparum Hep1 Is Required to Prevent the Self Aggregation of PfHsp70-3.
PMID:27253881
Ionotropic Receptors Identified within the Tentacle of the Freshwater Snail Biomphalaria glabrata, an Intermediate Host of Schistosoma mansoni.
PMID:27253696
Expression and Characterization of a Novel Glycerophosphodiester Phosphodiesterase from Pyrococcus furiosus DSM 3638 That Possesses Lysophospholipase D Activity.
PMID:27248999
Identification of variants in MBNL1 in patients with a myotonic dystrophy-like phenotype.
PMID:27222292
Computational Framework for Prediction of Peptide Sequences That May Mediate Multiple Protein Interactions in Cancer-Associated Hub Proteins.
PMID:27218803
VNAR single-domain antibodies specific for BAFF inhibit B cell development by molecular mimicry.
PMID:27213814
Defining the SUMO System in Maize: SUMOylation Is Up-Regulated during Endosperm Development and Rapidly Induced by Stress.
PMID:27208252
C-Terminal Region of Sulfite Reductase Is Important to Localize to Chloroplast Nucleoids in Land Plants.
PMID:27189994
What Characteristics Confer Proteins the Ability to Induce Allergic Responses? IgE Epitope Mapping and Comparison of the Structure of Soybean 2S Albumins and Ara h 2.
PMID:27187334
Norovirus (NoV) specific protective immune responses induced by recombinant P dimer vaccine are enhanced by the mucosal adjuvant FlaB.
PMID:27184355
Visualizing ensembles in structural biology.
PMID:27179343
Most neutralizing human monoclonal antibodies target novel epitopes requiring both Lassa virus glycoprotein subunits.
PMID:27161536
The Quantum Nature of Drug-Receptor Interactions: Deuteration Changes Binding Affinities for Histamine Receptor Ligands.
PMID:27159606
A novel heterozygous mutation in cardiac calsequestrin causes autosomal dominant catecholaminergic polymorphic ventricular tachycardia.
PMID:27157848
Independent Evolution of Six Families of Halogenating Enzymes.
PMID:27153321
RNA helicase SACY-1 is required for longevity caused by various genetic perturbations in Caenorhabditis elegans.
PMID:27153157
The TatD-like DNase of Plasmodium is a virulence factor and a potential malaria vaccine candidate.
PMID:27151551
The Cell Surface Receptor CD44: NMR-Based Characterization of Putative Ligands.
PMID:27144715
Open drug discovery for the Zika virus.
PMID:27134728
Identification of (Z)-3:(E)-2-Hexenal Isomerases Essential to the Production of the Leaf Aldehyde in Plants.
PMID:27129773
Tighter Control by Chymotrypsin C (CTRC) Explains Lack of Association between Human Anionic Trypsinogen and Hereditary Pancreatitis.
PMID:27129265
In Vivo Selection Yields AAV-B1 Capsid for Central Nervous System and Muscle Gene Therapy.
PMID:27117222
High-resolution mapping of a novel rat blood pressure locus on chromosome 9 to a region containing the Spp2 gene and colocalization of a QTL for bone mass.
PMID:27113531
Tcf1 and Lef1 transcription factors establish CD8(+) T cell identity through intrinsic HDAC activity.
PMID:27111144
Rational Design of Disulfide Bonds Increases Thermostability of a Mesophilic 1,3-1,4-β-Glucanase from Bacillus terquilensis.
PMID:27100881
ProViz-a web-based visualization tool to investigate the functional and evolutionary features of protein sequences.
PMID:27085803
Genome-wide analysis and expression profiling of glyoxalase gene families in soybean (Glycine max) indicate their development and abiotic stress specific response.
PMID:27083416
Integrating Genomics Into Clinical Pediatric Oncology Using the Molecular Tumor Board at the Memorial Sloan Kettering Cancer Center.
PMID:27082517
Bioinformatics and Molecular Analysis of the Evolutionary Relationship between Bovine Rhinitis A Viruses and Foot-And-Mouth Disease Virus.
PMID:27081310
Synergistic Modification Induced Specific Recognition between Histone and TRIM24 via Fluctuation Correlation Network Analysis.
PMID:27079666
Replenishing the cyclic-di-AMP pool: regulation of diadenylate cyclase activity in bacteria.
PMID:27074767
The dynamic organization of fungal acetyl-CoA carboxylase.
PMID:27073141
A mutation in the atrial-specific myosin light chain gene (MYL4) causes familial atrial fibrillation.
PMID:27066836
Mps1 (Monopolar Spindle 1) Protein Inhibition Affects Cellular Growth and Pro-Embryogenic Masses Morphology in Embryogenic Cultures of Araucaria angustifolia (Araucariaceae).
PMID:27064899
Mechanism of NMDA Receptor Inhibition and Activation.
PMID:27062927
Defining the roles for Vpr in HIV-1-associated neuropathogenesis.
PMID:27056720
Genome-wide mitochondrial DNA sequence variations and lower expression of OXPHOS genes predict mitochondrial dysfunction in oral cancer tissue.
PMID:27055661
Pseudomonas aeruginosa phage PaP1 DNA polymerase is an A-family DNA polymerase demonstrating ssDNA and dsDNA 3'-5' exonuclease activity.
PMID:27052734
Dual Acting Neuraminidase Inhibitors Open New Opportunities to Disrupt the Lethal Synergism between Streptococcus pneumoniae and Influenza Virus.
PMID:27047471
Structural Analysis of the Myo1c and Neph1 Complex Provides Insight into the Intracellular Movement of Neph1.
PMID:27044863
Molecular basis of caspase-1 polymerization and its inhibition by a new capping mechanism.
PMID:27043298
Recessive Inactivating Mutations in TBCK, Encoding a Rab GTPase-Activating Protein, Cause Severe Infantile Syndromic Encephalopathy.
PMID:27040692
Phylogenetic analysis of β-xylanase SRXL1 of Sporisorium reilianum and its relationship with families (GH10 and GH11) of Ascomycetes and Basidiomycetes.
PMID:27040368
Identification and Assessment of the Potential Allergenicity of 7S Vicilins in Olive (Olea europaea L.) Seeds.
PMID:27034939
In Silico Approach for SAR Analysis of the Predicted Model of DEPDC1B: A Novel Target for Oral Cancer.
PMID:27034663
Oligomerization as a strategy for cold adaptation: Structure and dynamics of the GH1 β-glucosidase from Exiguobacterium antarcticum B7.
PMID:27029646
Crystal Structure of Human Myotubularin-Related Protein 1 Provides Insight into the Structural Basis of Substrate Specificity.
PMID:27018598
Sequencing the GRHL3 Coding Region Reveals Rare Truncating Mutations and a Common Susceptibility Variant for Nonsyndromic Cleft Palate.
PMID:27018475
Genomic Insight into the Host-Endosymbiont Relationship of Endozoicomonas montiporae CL-33(T) with its Coral Host.
PMID:27014194
Both Epistasis and Diversifying Selection Drive the Structural Evolution of the Ebola Virus Glycoprotein Mucin-Like Domain.
PMID:27009964
Structure of promoter-bound TFIID and model of human pre-initiation complex assembly.
PMID:27007846
A simple method for studying the molecular mechanisms of ultraviolet and violet reception in vertebrates.
PMID:27001075
SAS-6 engineering reveals interdependence between cartwheel and microtubules in determining centriole architecture.
PMID:26999736
Mechanism of Germacradien-4-ol Synthase-Controlled Water Capture.
PMID:26998816
Targeted Genes Sequencing Identified a Novel 15 bp Deletion on GJA8 in a Chinese Family with Autosomal Dominant Congenital Cataracts.
PMID:26996484
Exclusion of small terminase mediated DNA threading models for genome packaging in bacteriophage T4.
PMID:26984529
Whole-Genome Identification, Phylogeny, and Evolution of the Cytochrome P450 Family 2 (CYP2) Subfamilies in Birds.
PMID:26979796
Mycocerosic acid synthase exemplifies the architecture of reducing polyketide synthases.
PMID:26976449
Two highly similar LAEDDTNAQKT and LTDKIGTEI epitopes in G glycoprotein may be useful for effective epitope based vaccine design against pathogenic Henipavirus.
PMID:26970211
Allantoin transport protein, PucI, from Bacillus subtilis: evolutionary relationships, amplified expression, activity and specificity.
PMID:26967546
Ion Channel Function and Cross-Species Determinants in Viral Assembly of Nonprimate Hepacivirus p7.
PMID:26962224
Functional Transplant of a Dengue Virus Serotype 3 (DENV3)-Specific Human Monoclonal Antibody Epitope into DENV1.
PMID:26962223
NETTAB 2014: From high-throughput structural bioinformatics to integrative systems biology.
PMID:26960985
The Most Prevalent Freeman-Sheldon Syndrome Mutations in the Embryonic Myosin Motor Share Functional Defects.
PMID:26945064
New insights into the roles of the N-terminal region of the ABCC6 transporter.
PMID:26942607
A Heterologous Multiepitope DNA Prime/Recombinant Protein Boost Immunisation Strategy for the Development of an Antiserum against Micrurus corallinus (Coral Snake) Venom.
PMID:26938217
Statistical prediction of protein structural, localization and functional properties by the analysis of its fragment mass distributions after proteolytic cleavage.
PMID:26924271
Genome-Wide Identification of Mitogen-Activated Protein Kinase Gene Family across Fungal Lineage Shows Presence of Novel and Diverse Activation Loop Motifs.
PMID:26918378
CRISPR/Cas9-mediated GJA8 knockout in rabbits recapitulates human congenital cataracts.
PMID:26912477
cDNA sequence and protein bioinformatics analyses of MSTN in African catfish (Clarias gariepinus).
PMID:26912268
Evolutionary Dynamics of Floral Homeotic Transcription Factor Protein-Protein Interactions.
PMID:26908583
The Proliferating Cell Nuclear Antigen (PCNA)-interacting Protein (PIP) Motif of DNA Polymerase η Mediates Its Interaction with the C-terminal Domain of Rev1.
PMID:26903512
A novel mutation in TRPV3 gene causes atypical familial Olmsted syndrome.
PMID:26902751
Sequence Requirements for Neuropilin-2 Recognition by ST8SiaIV and Polysialylation of Its O-Glycans.
PMID:26884342
Product Rearrangement from Altering a Single Residue in the Rice syn-Copalyl Diphosphate Synthase.
PMID:26878189
The next generation of metastatic melanoma: uncovering the genetic variants for anti-BRAF therapy response.
PMID:26863566
Identification and Characterization of IgdE, a Novel IgG-degrading Protease of Streptococcus suis with Unique Specificity for Porcine IgG.
PMID:26861873
WrpA Is an Atypical Flavodoxin Family Protein under Regulatory Control of the Brucella abortus General Stress Response System.
PMID:26858101
Structure of the eukaryotic replicative CMG helicase suggests a pumpjack motion for translocation.
PMID:26854665
A trehalase from Zunongwangia sp.: characterization and improving catalytic efficiency by directed evolution.
PMID:26822136
Comparative genome-wide analysis and evolutionary history of haemoglobin-processing and haem detoxification enzymes in malarial parasites.
PMID:26821618
Systems-Wide Prediction of Enzyme Promiscuity Reveals a New Underground Alternative Route for Pyridoxal 5'-Phosphate Production in E. coli.
PMID:26821166
Autosomal-Recessive Hearing Impairment Due to Rare Missense Variants within S1PR2.
PMID:26805784
The ubiquitin ligase Ubr4 controls stability of podocin/MEC-2 supercomplexes.
PMID:26792178
Evolution of the Plant Reproduction Master Regulators LFY and the MADS Transcription Factors: The Role of Protein Structure in the Evolutionary Development of the Flower.
PMID:26779227
Characterization of a New M13 Metallopeptidase from Deep-Sea Shewanella sp. E525-6 and Mechanistic Insight into Its Catalysis.
PMID:26779153
Characterization of the First α-(1→3) Branching Sucrases of the GH70 Family.
PMID:26763236
Critical Molecular Determinants of α7 Nicotinic Acetylcholine Receptor Allosteric Activation: SEPARATION OF DIRECT ALLOSTERIC ACTIVATION AND POSITIVE ALLOSTERIC MODULATION.
PMID:26742843
Creation of chimeric human/rabbit APOBEC1 with HIV-1 restriction and DNA mutation activities.
PMID:26738439
Redirection of the Reaction Specificity of a Thermophilic Acetolactate Synthase toward Acetaldehyde Formation.
PMID:26731734
Evaluation of a DLA-79 allele associated with multiple immune-mediated diseases in dogs.
PMID:26711123
Structural Evolution of the Emerging 2014-2015 GII.17 Noroviruses.
PMID:26699640
Analysis of the interaction between host factor Sam68 and viral elements during foot-and-mouth disease virus infections.
PMID:26695943
Protein Structure and Function Prediction Using I-TASSER.
PMID:26678386
The Potential Mutation of GAK Gene in the Typical Sporadic Parkinson's Disease from the Han Population of Chinese Mainland.
PMID:26676575
Purification, Cloning and Immuno-Biochemical Characterization of a Fungal Aspartic Protease Allergen Rhi o 1 from the Airborne Mold Rhizopus oryzae.
PMID:26672984
Functional prediction of hypothetical proteins in human adenoviruses.
PMID:26664031
Missense mutations in progranulin gene associated with frontotemporal lobar degeneration: study of pathogenetic features.
PMID:26652843
Signal transduction in light-oxygen-voltage receptors lacking the adduct-forming cysteine residue.
PMID:26648256
Structural Insight into How Bacteria Prevent Interference between Multiple Divergent Type IV Secretion Systems.
PMID:26646013
Dimerization of the SP1 Region of HIV-1 Gag Induces a Helical Conformation and Association into Helical Bundles: Implications for Particle Assembly.
PMID:26637452
Convergent Evolution of Hemoglobin Function in High-Altitude Andean Waterfowl Involves Limited Parallelism at the Molecular Sequence Level.
PMID:26637114
Structural studies of UBXN2A and mortalin interaction and the putative role of silenced UBXN2A in preventing response to chemotherapy.
PMID:26634371
Engineering a novel glucose-tolerant β-glucosidase as supplementation to enhance the hydrolysis of sugarcane bagasse at high glucose concentration.
PMID:26628916
Targeted silencing of the Aquaporin 2 gene of Rhipicephalus (Boophilus) microplus reduces tick fitness.
PMID:26626727
The SIB Swiss Institute of Bioinformatics' resources: focus on curated databases.
PMID:26615188
Genomic and evolutionary inferences between American and global strains of porcine epidemic diarrhea virus.
PMID:26611651
A mechanism of glucose tolerance and stimulation of GH1 β-glucosidases.
PMID:26603650
Boramino acid as a marker for amino acid transporters.
PMID:26601275
Characterizing non-hydrolyzing Neisseria meningitidis serogroup A UDP-N-acetylglucosamine (UDP-GlcNAc) 2-epimerase using UDP-N-acetylmannosamine (UDP-ManNAc) and derivatives.
PMID:26598987
The peptide agonist-binding site of the glucagon-like peptide-1 (GLP-1) receptor based on site-directed mutagenesis and knowledge-based modelling.
PMID:26598711
Regulation of a Protein Acetyltransferase in Myxococcus xanthus by the Coenzyme NADP.
PMID:26598367
Structural Studies of Geosmin Synthase, a Bifunctional Sesquiterpene Synthase with αα Domain Architecture That Catalyzes a Unique Cyclization-Fragmentation Reaction Sequence.
PMID:26598179
The activity of protein phosphatase 5 towards native clients is modulated by the middle- and C-terminal domains of Hsp90.
PMID:26593036
The N-terminal Helical Region of the Hepatitis C Virus p7 Ion Channel Protein Is Critical for Infectious Virus Production.
PMID:26588073
The Relay/Converter Interface Influences Hydrolysis of ATP by Skeletal Muscle Myosin II.
PMID:26586917
Lignocellulose degradation mechanisms across the Tree of Life.
PMID:26583519
Structural basis for antagonizing a host restriction factor by C7 family of poxvirus host-range proteins.
PMID:26578811
Interaction of the N-(3-Methylpyridin-2-yl)amide Derivatives of Flurbiprofen and Ibuprofen with FAAH: Enantiomeric Selectivity and Binding Mode.
PMID:26565710
Cross-linking immunoprecipitation-MS (xIP-MS): Topological Analysis of Chromatin-associated Protein Complexes Using Single Affinity Purification.
PMID:26560067
Guanine nucleotide binding to the Bateman domain mediates the allosteric inhibition of eukaryotic IMP dehydrogenases.
PMID:26558346
Identification of a Novel Di-D-Fructofuranose 1,2':2,3' Dianhydride (DFA III) Hydrolysis Enzyme from Arthrobacter aurescens SK8.001.
PMID:26555784
Gene Mutation Analysis in 253 Chinese Children with Unexplained Epilepsy and Intellectual/Developmental Disabilities.
PMID:26544041
Functional characterization of a yellow laccase from Leucoagaricus gongylophorus.
PMID:26543788
HOXB9 induction of mesenchymal-to-epithelial transition in gastric carcinoma is negatively regulated by its hexapeptide motif.
PMID:26536658
Biophysical Studies of Bacterial Topoisomerases Substantiate Their Binding Modes to an Inhibitor.
PMID:26536273
Identification and Characterization of the Interaction Site between cFLIPL and Calmodulin.
PMID:26529318
Identification and Characterization of a New 7-Aminocephalosporanic Acid Deacetylase from Thermophilic Bacterium Alicyclobacillus tengchongensis.
PMID:26527640
A bioinformatic survey of RNA-binding proteins in Plasmodium.
PMID:26525978
Non-classical amine recognition evolved in a large clade of olfactory receptors.
PMID:26519734
Evaluation of the Conformational Stability of Recombinant Desulfurizing Enzymes from a Newly Isolated Rhodococcus sp.
PMID:26515071
Understanding the fabric of protein crystals: computational classification of biological interfaces and crystal contacts.
PMID:26508758
Phylogenomics and sequence-structure-function relationships in the GmrSD family of Type IV restriction enzymes.
PMID:26493560
Mixed-mode resins: taking shortcut in downstream processing of raw-starch digesting α-amylases.
PMID:26492875
A Naturally Occurring Domestic Cat APOBEC3 Variant Confers Resistance to Feline Immunodeficiency Virus Infection.
PMID:26491161
A Nucleolar PUF RNA-binding Protein with Specificity for a Unique RNA Sequence.
PMID:26487722
Inhibition on JAK-STAT3 Signaling Transduction Cascade Is Taken by Bioactive Peptide Alpha-S2 Casein Protein from Goat Ethawah Breed Milk.
PMID:26483598
Molecular pathogenesis of H5 highly pathogenic avian influenza: the role of the haemagglutinin cleavage site motif.
PMID:26467906
Structural and functional features of a developmentally regulated lipopolysaccharide-binding protein.
PMID:26463160
Contribution of a mutational hot spot to hemoglobin adaptation in high-altitude Andean house wrens.
PMID:26460028
Structure of the response regulator RPA3017 involved in red-light signaling in Rhodopseudomonas palustris.
PMID:26457509
Biochemical Characterization and Substrate Specificity of Autophagin-2 from the Parasite Trypanosoma cruzi.
PMID:26446788
A Functional EXXEK Motif is Essential for Proton Coupling and Active Glucosinolate Transport by NPF2.11.
PMID:26443378
Long-term survival of Borrelia burgdorferi lacking the hibernation promotion factor homolog in the unfed tick vector.
PMID:26438790
Peroxiredoxin 6 from the Antarctic emerald rockcod: molecular characterization of its response to warming.
PMID:26433650
Divergence and adaptive evolution of the gibberellin oxidase genes in plants.
PMID:26416509
Structural analysis of tumor-related single amino acid mutations in human MxA protein.
PMID:26411585
Bioinformatic characterization of glycyl radical enzyme-associated bacterial microcompartments.
PMID:26407889
Independent Mechanisms Target SMCHD1 to Trimethylated Histone H3 Lysine 9-Modified Chromatin and the Inactive X Chromosome.
PMID:26391951
Characterization and directed evolution of a methyl-binding domain protein for high-sensitivity DNA methylation analysis.
PMID:26384511
Epigallocatechin gallate affects glucose metabolism and increases fitness and lifespan in Drosophila melanogaster.
PMID:26375250
Identification by Random Mutagenesis of Functional Domains in KREPB5 That Differentially Affect RNA Editing between Life Cycle Stages of Trypanosoma brucei.
PMID:26370513
Structure and Mechanism of a Viral Collagen Prolyl Hydroxylase.
PMID:26368022
A Cell-based Fluorescence Resonance Energy Transfer (FRET) Sensor Reveals Inter- and Intragenogroup Variations in Norovirus Protease Activity and Polyprotein Cleavage.
PMID:26363064
Inhibition of elongin C promotes longevity and protein homeostasis via HIF-1 in C. elegans.
PMID:26361075
Growth-Phase-Specific Modulation of Cell Morphology and Gene Expression by an Archaeal Histone Protein.
PMID:26350964
Epitopes in α8β1 and other RGD-binding integrins delineate classes of integrin-blocking antibodies and major binding loops in α subunits.
PMID:26349930
The Structural Characterization of Tumor Fusion Genes and Proteins.
PMID:26347798
Phosphorylation at serine 52 and 635 does not alter the transport properties of glucosinolate transporter AtGTR1.
PMID:26340317
Streamlined Construction of the Cyanobacterial CO2-Fixing Organelle via Protein Domain Fusions for Use in Plant Synthetic Biology.
PMID:26320224
YjeH Is a Novel Exporter of l-Methionine and Branched-Chain Amino Acids in Escherichia coli.
PMID:26319875
Structural Basis for Substrate Specificity in Adenosylcobalamin-dependent Isobutyryl-CoA Mutase and Related Acyl-CoA Mutases.
PMID:26318610
Characterization of the Role of β-Carotene 9,10-Dioxygenase in Macular Pigment Metabolism.
PMID:26307071
Differential Editosome Protein Function between Life Cycle Stages of Trypanosoma brucei.
PMID:26304125
Efflux-mediated resistance to a benzothiadiazol derivative effective against Burkholderia cenocepacia.
PMID:26300878
Cardiolipin Interactions with Proteins.
PMID:26300339
Assessing the genetic diversity of Cu resistance in mine tailings through high-throughput recovery of full-length copA genes.
PMID:26286020
A Newly-Identified Polymorphism in Rhesus Macaque Complement Factor H Modulates Binding Affinity for Meningococcal FHbp.
PMID:26285122
Functional properties and structural characterization of rice δ(1)-pyrroline-5-carboxylate reductase.
PMID:26284087
Matrix Metalloproteinase (MMP) Proteolysis of the Extracellular Loop of Voltage-gated Sodium Channels and Potential Alterations in Pain Signaling.
PMID:26283785
Crucial role of the orexin-B C-terminus in the induction of OX1 receptor-mediated apoptosis: analysis by alanine scanning, molecular modelling and site-directed mutagenesis.
PMID:26282891
Characterization of the Catalytic Domain of Human APOBEC3B and the Critical Structural Role for a Conserved Methionine.
PMID:26281709
Identification, Phylogeny, and Function of fabp2 Paralogs in Two Non-Model Teleost Fish Species.
PMID:26272429
Structure of α-carbonic anhydrase from the human pathogen Helicobacter pylori.
PMID:26249690
The Evolution of the Secreted Regulatory Protein Progranulin.
PMID:26248158
Functionality of Class A and Class B J-protein co-chaperones with Hsp70.
PMID:26247431
Two Novel NYX Gene Mutations in the Chinese Families with X-linked Congenital Stationary Night Blindness.
PMID:26234941
Identification of two novel critical mutations in PCNT gene resulting in microcephalic osteodysplastic primordial dwarfism type II associated with multiple intracranial aneurysms.
PMID:26231886
Evidence of Positive Selection of Aquaporins Genes from Pontoporia blainvillei during the Evolutionary Process of Cetaceans.
PMID:26226365
Study of the Binding Energies between Unnatural Amino Acids and Engineered Orthogonal Tyrosyl-tRNA Synthetases.
PMID:26220470
Molecular basis of claudin-17 anion selectivity.
PMID:26194246
Identification of interleukin-26 in the dromedary camel (Camelus dromedarius): Evidence of alternative splicing and isolation of novel splice variants.
PMID:26190308
Mutations Affecting Keratin 10 Surface-Exposed Residues Highlight the Structural Basis of Phenotypic Variation in Epidermolytic Ichthyosis.
PMID:26176760
Identification, mRNA expression profiling and activity characterization of cathepsin L from red drum (Sciaenops ocellatus).
PMID:26164862
Against All Odds: Trehalose-6-Phosphate Synthase and Trehalase Genes in the Bdelloid Rotifer Adineta vaga Were Acquired by Horizontal Gene Transfer and Are Upregulated during Desiccation.
PMID:26161530
Enhancement of E. coli acyl-CoA synthetase FadD activity on medium chain fatty acids.
PMID:26157619
Known structure, unknown function: An inquiry-based undergraduate biochemistry laboratory course.
PMID:26148241
Identification and Characterization of 40 Isolated Rehmannia glutinosa MYB Family Genes and Their Expression Profiles in Response to Shading and Continuous Cropping.
PMID:26147429
AVP-NPII gene mutations and clinical characteristics of the patients with autosomal dominant familial central diabetes insipidus.
PMID:26134705
Staphylococcus aureus PerR Is a Hypersensitive Hydrogen Peroxide Sensor using Iron-mediated Histidine Oxidation.
PMID:26134568
Manganese lipoxygenase of F. oxysporum and the structural basis for biosynthesis of distinct 11-hydroperoxy stereoisomers.
PMID:26113537
Identification and characterization of a HEPN-MNT family type II toxin-antitoxin in Shewanella oneidensis.
PMID:26112399
Post-translationally-modified structures in the autophagy machinery: an integrative perspective.
PMID:26108642
In Silico Prediction and Experimental Confirmation of HA Residues Conferring Enhanced Human Receptor Specificity of H5N1 Influenza A Viruses.
PMID:26091504
Non-syndromic hearing loss caused by the dominant cis mutation R75Q with the recessive mutation V37I of the GJB2 (Connexin 26) gene.
PMID:26088551
A Three-protein Charge Zipper Stabilizes a Complex Modulating Bacterial Gene Silencing.
PMID:26085102
Identification of amino acids involved in histamine potentiation of GABA A receptors.
PMID:26074818
Molecular Evolutionary Analysis of β-Defensin Peptides in Vertebrates.
PMID:26056425
New Insights into the Coupling between Microtubule Depolymerization and ATP Hydrolysis by Kinesin-13 Protein Kif2C.
PMID:26055718
Probing the Biology of Giardia intestinalis Mitosomes Using In Vivo Enzymatic Tagging.
PMID:26055323
In silico identification of AMPylating enzymes and study of their divergent evolution.
PMID:26039278
Identification of a putative quantitative trait nucleotide in guanylate binding protein 5 for host response to PRRS virus infection.
PMID:26016888
Water-soluble chlorophyll protein is involved in herbivore resistance activation during greening of Arabidopsis thaliana.
PMID:26016527
Molecular interactions of the Saccharomyces cerevisiae Atg1 complex provide insights into assembly and regulatory mechanisms.
PMID:25998554
Bioinformatical analysis of the sequences, structures and functions of fungal polyketide synthase product template domains.
PMID:25995122
Structural Insights into Substrate Specificity of Feruloyl-CoA 6'-Hydroxylase from Arabidopsis thaliana.
PMID:25993561
ATP-dependent Conformational Changes Trigger Substrate Capture and Release by an ECF-type Biotin Transporter.
PMID:25991724
A New Family of HEAT-Like Repeat Proteins Lacking a Critical Substrate Recognition Motif Present in Related DNA Glycosylases.
PMID:25978435
Arg(1809) substitution in neurofibromin: further evidence of a genotype-phenotype correlation in neurofibromatosis type 1.
PMID:25966637
NGL Viewer: a web application for molecular visualization.
PMID:25925569
MJD and OTU deubiquitinating enzymes in Schistosoma mansoni.
PMID:25924794
Dissecting the fungal biology of Bipolaris papendorfii: from phylogenetic to comparative genomic analysis.
PMID:25922537
Incorporation of Peptides Targeting EGFR and FGFR1 into the Adenoviral Fiber Knob Domain and Their Evaluation as Targeted Cancer Therapies.
PMID:25919378
A Moonlighting Human Protein Is Involved in Mitochondrial Import of tRNA.
PMID:25918939
Identification and functional characterization of the CYP51 gene from the yeast Xanthophyllomyces dendrorhous that is involved in ergosterol biosynthesis.
PMID:25906980
Characterization of the Ubiquitin-Conjugating Enzyme Gene Family in Rice and Evaluation of Expression Profiles under Abiotic Stresses and Hormone Treatments.
PMID:25902049
RBO Aleph: leveraging novel information sources for protein structure prediction.
PMID:25897112
The exchanged EF-hands in calmodulin and troponin C chimeras impair the Ca²⁺-induced hydrophobicity and alter the interaction with Orai1: a spectroscopic, thermodynamic and kinetic study.
PMID:25888318
Expression of the Thermobifida fusca xylanase Xyn11A in Pichia pastoris and its characterization.
PMID:25887328
Comparative analysis of cystatin superfamily in platyhelminths.
PMID:25853513
Increased efficiency of Campylobacter jejuni N-oligosaccharyltransferase PglB by structure-guided engineering.
PMID:25833378
Chlorotoxin: a helpful natural scorpion peptide to diagnose glioma and fight tumor invasion.
PMID:25826056
The class III cyclobutane pyrimidine dimer photolyase structure reveals a new antenna chromophore binding site and alternative photoreduction pathways.
PMID:25784552
The Radical S-Adenosyl-L-methionine Enzyme QhpD Catalyzes Sequential Formation of Intra-protein Sulfur-to-Methylene Carbon Thioether Bonds.
PMID:25778402
Four crystal structures of human LLT1, a ligand of human NKR-P1, in varied glycosylation and oligomerization states.
PMID:25760607
Structures of three polycystic kidney disease-like domains from Clostridium histolyticum collagenases ColG and ColH.
PMID:25760606
MutT from the fish pathogen Aliivibrio salmonicida is a cold-active nucleotide-pool sanitization enzyme with unexpectedly high thermostability.
PMID:25737836
Specific disulfide cross-linking to constrict the mobile carrier domain of nonribosomal peptide synthetases.
PMID:25713404
Whole transcriptome analysis using next-generation sequencing of sterile-cultured Eisenia andrei for immune system research.
PMID:25706644
Structural analysis of the complex between penta-EF-hand ALG-2 protein and Sec31A peptide reveals a novel target recognition mechanism of ALG-2.
PMID:25667979
Propofol inhibits SIRT2 deacetylase through a conformation-specific, allosteric site.
PMID:25666612
Two-tiered histidine kinase pathway involved in heat shock and salt sensing in the general stress response of Sphingomonas melonis Fr1.
PMID:25666137
In silico analysis and developmental expression of ubiquitin-conjugating enzymes in Schistosoma mansoni.
PMID:25663106
PICK1 is implicated in organelle motility in an Arp2/3 complex-independent manner.
PMID:25657323
Mutagenesis and functional analysis of the pore-forming toxin HALT-1 from Hydra magnipapillata.
PMID:25654788
In vitro activity of five quinolones and analysis of the quinolone resistance-determining regions of gyrA, gyrB, parC, and parE in Ureaplasma parvum and Ureaplasma urealyticum clinical isolates from perinatal patients in Japan.
PMID:25645833
Limited effect of recombinant human mannose-binding lectin on the infection of novel influenza A (H7N9) virus in vitro.
PMID:25634695
Local error estimates dramatically improve the utility of homology models for solving crystal structures by molecular replacement.
PMID:25619999
Data to knowledge: how to get meaning from your result.
PMID:25610627
Structure, bioactivity, and resistance mechanism of streptomonomicin, an unusual lasso Peptide from an understudied halophilic actinomycete.
PMID:25601074
A mechanistic role of Helix 8 in GPCRs: Computational modeling of the dopamine D2 receptor interaction with the GIPC1-PDZ-domain.
PMID:25592838
The CarO rhodopsin of the fungus Fusarium fujikuroi is a light-driven proton pump that retards spore germination.
PMID:25589426
The Ordospora colligata genome: Evolution of extreme reduction in microsporidia and host-to-parasite horizontal gene transfer.
PMID:25587016
A hypertrophic cardiomyopathy-associated MYBPC3 mutation common in populations of South Asian descent causes contractile dysfunction.
PMID:25583989
Mechanistic insights into the recycling machine of the SNARE complex.
PMID:25581794
Germline ETV6 mutations in familial thrombocytopenia and hematologic malignancy.
PMID:25581430
The majority of transcripts in the squid nervous system are extensively recoded by A-to-I RNA editing.
PMID:25569156
Protein sector analysis for the clustering of disease-associated mutations.
PMID:25559331
Alginate lyases from alginate-degrading Vibrio splendidus 12B01 are endolytic.
PMID:25556193
Identifying tandem Ankyrin repeats in protein structures.
PMID:25547411
Conserved amino acid residues of the NuoD segment important for structure and function of Escherichia coli NDH-1 (complex I).
PMID:25545070
Crystal structure of DNA cytidine deaminase ABOBEC3G catalytic deamination domain suggests a binding mode of full-length enzyme to single-stranded DNA.
PMID:25542899
Two desmin gene mutations associated with myofibrillar myopathies in Polish families.
PMID:25541946
Structure and function analysis of nucleocapsid protein of tomato spotted wilt virus interacting with RNA using homology modeling.
PMID:25540203
Engineering of Glarea lozoyensis for exclusive production of the pneumocandin B0 precursor of the antifungal drug caspofungin acetate.
PMID:25527531
The olfactomedin domain from gliomedin is a β-propeller with unique structural properties.
PMID:25525261
Determinants of endogenous ligand specificity divergence among metabotropic glutamate receptors.
PMID:25519912
Outward-facing conformers of LacY stabilized by nanobodies.
PMID:25512549
Novel Anti-Nicotine Vaccine Using a Trimeric Coiled-Coil Hapten Carrier.
PMID:25494044
Conformational dynamics in substrate-binding domains influences transport in the ABC importer GlnPQ.
PMID:25486304
Exploring the interactions between isoprenoid chain and labdenediol diphosphate synthase based on molecular docking and quartz crystal microbalance.
PMID:25472483
Unexpected challenges in treating multidrug-resistant Gram-negative bacteria: resistance to ceftazidime-avibactam in archived isolates of Pseudomonas aeruginosa.
PMID:25451057
Characterization of the Drosophila group ortholog to the amino-terminus of the alpha-thalassemia and mental retardation X-Linked (ATRX) vertebrate protein.
PMID:25437195
cDNA structure and the effect of fasting on myostatin expression in walking catfish (Clarias macrocephalus, Günther 1864).
PMID:25432578
New Approaches to Comparative and Animal Stress Biology Research in the Post-genomic Era: A Contextual Overview.
PMID:25408848
A review of metabolic and enzymatic engineering strategies for designing and optimizing performance of microbial cell factories.
PMID:25379147
Identification and structural analysis of an L-asparaginase enzyme from guinea pig with putative tumor cell killing properties.
PMID:25320094
Distinct conformational behaviors of four mammalian dual-flavin reductases (cytochrome P450 reductase, methionine synthase reductase, neuronal nitric oxide synthase, endothelial nitric oxide synthase) determine their unique catalytic profiles.
PMID:25265015
Molecular modeling and MM-PBSA free energy analysis of endo-1,4-β-xylanase from Ruminococcus albus 8.
PMID:25264743
Hotspot activating PRKD1 somatic mutations in polymorphous low-grade adenocarcinomas of the salivary glands.
PMID:25240283
Characterization of a broadly neutralizing monoclonal antibody that targets the fusion domain of group 2 influenza A virus hemagglutinin.
PMID:25210195
Recombinant expression, purification, crystallization and preliminary X-ray diffraction analysis of the C-terminal DUF490(963-1138) domain of TamB from Escherichia coli.
PMID:25195908
Assessing the local structural quality of transmembrane protein models using statistical potentials (QMEANBrane).
PMID:25161240
Molecular and evolutionary analysis of NEAr-iron Transporter (NEAT) domains.
PMID:25153520
Structure of the RNA polymerase assembly factor Crl and identification of its interaction surface with sigma S.
PMID:25002538
Leveraging structure for enzyme function prediction: methods, opportunities, and challenges.
PMID:24998033
Fifteen years SIB Swiss Institute of Bioinformatics: life science databases, tools and support.
PMID:24792157