Reframedb

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Reframedb

metasource: Fairsharing.org
version: None

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ReFRAME

metasource: bio.tools
version: extracted_at: 2022-11-04T11:26:36.844554

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reframe

metasource: bio.tools
version: extracted_at: 2022-11-04T11:26:36.844554

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Other names: ReFRAME, reframe

Reframedb is a comprehensive open-access, drug repositioning screening set of 12,000 compounds that was assembled by combining three widely-used commercial drug competitive intelligence databases (Clarivate Integrity, GVK Excelra GoStar and Citeline Pharmaprojects), together with extensive patent mining of small molecules that have been dosed in humans. To date ~12,000 compounds (~80% of compounds identified from data mining) have been purchased or synthesized, and subsequently plated for screening.

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Publications

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The ReFRAME library as a comprehensive drug repurposing library and its application to the treatment of cryptosporidiosis
PMID: 30282735

metasource: Fairsharing.org
version: None

metasource: bio.tools
version: extracted_at: 2022-11-04T11:26:36.844554

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• The ReFRAME library as a comprehensive drug repurposing library and its application to the treatment of cryptosporidiosis PubMed citations: 70.

  70 articles citing: The ReFRAME library as a comprehensive drug repurposing library and its application to the treatment of cryptosporidiosis

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  An update on Cryptosporidium biology and therapeutic avenues. PMID:35755159

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  Aspartyl Protease Inhibitors as Anti-Filarial Drugs. PMID:35745561

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  Repurposing the Kinase Inhibitor Mavelertinib for Giardiasis Therapy. PMID:35703552

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  Molnupiravir combined with different repurposed drugs further inhibits SARS-CoV-2 infection in human nasal epithelium in vitro. PMID:35658229

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  RNA-Based Therapy for Cryptosporidium parvum Infection: Proof-of-Concept Studies. PMID:35647663

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  Inhibitors of SARS-CoV-2 PLpro. PMID:35559224

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  Insights Into Drug Repurposing, as Well as Specificity and Compound Properties of Piperidine-Based SARS-CoV-2 PLpro Inhibitors. PMID:35494659

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  Comprehensive network medicine-based drug repositioning via integration of therapeutic efficacy and side effects. PMID:35443763

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  NF-κB Signaling and Inflammation-Drug Repurposing to Treat Inflammatory Disorders? PMID:35336746

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  A promising strategy against SARS-CoV-2: pyrimidine inhibitors synergize with nucleoside analogues. PMID:35292618

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  The Pandemic Response Box─Accelerating Drug Discovery Efforts after Disease Outbreaks. PMID:35286809

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  Pyrimidine inhibitors synergize with nucleoside analogues to block SARS-CoV-2. PMID:35130559

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  Identification of potent small molecule inhibitors of SARS-CoV-2 entry. PMID:35058179

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  Compounds enhancing human sperm motility identified using a high-throughput phenotypic screening platform. PMID:35048946

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  Ponatinib, Lestaurtinib, and mTOR/PI3K Inhibitors Are Promising Repurposing Candidates against Entamoeba histolytica. PMID:34871094

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  Drug repurposing for COVID-19 using graph neural network and harmonizing multiple evidence. PMID:34848761

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  Current status of structure-based drug repurposing against COVID-19 by targeting SARS-CoV-2 proteins. PMID:34745807

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  Host-directed therapy, an untapped opportunity for antimalarial intervention. PMID:34693368

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  Deep learning identifies synergistic drug combinations for treating COVID-19. PMID:34526388

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  Reprogramming of Protein-Targeted Small-Molecule Medicines to RNA by Ribonuclease Recruitment. PMID:34387474

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  Emerging hiPSC Models for Drug Discovery in Neurodegenerative Diseases. PMID:34360966

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  Impact of hemoglobin biophysical studies on molecular pathogenesis and drug therapy for sickle cell disease. PMID:34274158

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  COVID-19 Therapeutics for Low- and Middle-Income Countries: A Review of Candidate Agents with Potential for Near-Term Use and Impact. PMID:34270449

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  Progress and pitfalls of a year of drug repurposing screens against COVID-19. PMID:34218010

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  Can Antiviral Activity of Licorice Help Fight COVID-19 Infection? PMID:34201172

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  Bispecific repurposed medicines targeting the viral and immunological arms of COVID-19. PMID:34168183

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  The Use of Informer Sets in Screening: Perspectives on an Efficient Strategy to Identify New Probes. PMID:34130532

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  Drug repurposing screens identify chemical entities for the development of COVID-19 interventions. PMID:34083527

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  A transferable deep learning approach to fast screen potential antiviral drugs against SARS-CoV-2. PMID:34081143

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  Attacking COVID-19 Progression Using Multi-Drug Therapy for Synergetic Target Engagement. PMID:34071060

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  LigAdvisor: a versatile and user-friendly web-platform for drug design. PMID:34023895

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  Strategy, Progress, and Challenges of Drug Repurposing for Efficient Antiviral Discovery. PMID:34017257

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  High-throughput screening of the ReFRAME, Pandemic Box, and COVID Box drug repurposing libraries against SARS-CoV-2 nsp15 endoribonuclease to identify small-molecule inhibitors of viral activity. PMID:33886614

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  Rediscovery of PF-3845 as a new chemical scaffold inhibiting phenylalanyl-tRNA synthetase in Mycobacterium tuberculosis. PMID:33837735

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  Opportunities and Challenges in Developing a Cryptosporidium Controlled Human Infection Model for Testing Antiparasitic Agents. PMID:33822577

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  Discovery and functional interrogation of SARS-CoV-2 RNA-host protein interactions. PMID:33743211

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  Use-case scenarios for an anti-Cryptosporidium therapeutic. PMID:33705395

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  Drug Repurposing and Polypharmacology to Fight SARS-CoV-2 Through Inhibition of the Main Protease. PMID:33692695

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  Pyrrolopyrimidine Bumped Kinase Inhibitors for the Treatment of Cryptosporidiosis. PMID:33565854

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  Biomarkers of COVID-19 and technologies to combat SARS-CoV-2. PMID:33511330

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  An Integrated Approach to Identify New Anti-Filarial Leads to Treat River Blindness, a Neglected Tropical Disease. PMID:33466870

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  Drug Repurposing for COVID-19 using Graph Neural Network with Genetic, Mechanistic, and Epidemiological Validation. PMID:33330858

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  Screening the CALIBR ReFRAME Library in Search for Inhibitors of Candida auris Biofilm Formation. PMID:33324579

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  Diamond Light Source: contributions to SARS-CoV-2 biology and therapeutics. PMID:33248689

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  Sperm ion channels and transporters in male fertility and infertility. PMID:33214707

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  REDIAL-2020: A Suite of Machine Learning Models to Estimate Anti-SARS-CoV-2 Activities. PMID:33200119

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  A computational study to disclose potential drugs and vaccine ensemble for COVID-19 conundrum. PMID:33199930

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  High-Throughput Screening for Drugs That Inhibit Papain-Like Protease in SARS-CoV-2. PMID:33043784

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  Imatinib is not a potent anti-SARS-CoV-2 drug. PMID:32999432

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  Bicyclic azetidines kill the diarrheal pathogen Cryptosporidium in mice by inhibiting parasite phenylalanyl-tRNA synthetase. PMID:32998973

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  Large-scale RNAi screening uncovers therapeutic targets in the parasite Schistosoma mansoni. PMID:32973031

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  Discovery of repurposing drug candidates for the treatment of diseases caused by pathogenic free-living amoebae. PMID:32970675

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  A Conditional Protein Degradation System To Study Essential Gene Function in Cryptosporidium parvum. PMID:32843543

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  Advances in Genomics for Drug Development. PMID:32824125

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  Clinical trials to assess adjuvant therapeutics for severe malaria. PMID:32709257

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  Discovery of SARS-CoV-2 antiviral drugs through large-scale compound repurposing. PMID:32707573

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  Advancing computer-aided drug discovery (CADD) by big data and data-driven machine learning modeling. PMID:32663517

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  A nutrient-limited screen unmasks rifabutin hyperactivity for extensively drug-resistant Acinetobacter baumannii. PMID:32514072

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  An up-to-date overview of computational polypharmacology in modern drug discovery. PMID:32452701

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  High-Throughput Screening of the ReFRAME Library Identifies Potential Drug Repurposing Candidates for Trypanosoma cruzi. PMID:32224991

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  Identification of anisomycin, prodigiosin and obatoclax as compounds with broad-spectrum anti-parasitic activity. PMID:32196500

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  A systems approach to infectious disease. PMID:32060427

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  A phenotypic screening platform utilising human spermatozoa identifies compounds with contraceptive activity. PMID:31987071

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  Identification and Characterization of Novel Compounds with Broad-Spectrum Antiviral Activity against Influenza A and B Viruses. PMID:31941776

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  Drug repurposing to improve treatment of rheumatic autoimmune inflammatory diseases. PMID:31831878

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  Discovery of Small Molecules for the Reversal of T Cell Exhaustion. PMID:31801090

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  Hemoglobin S polymerization and sickle cell disease: A retrospective on the occasion of the 70th anniversary of Pauling's Science paper. PMID:31763707

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  Identification of plicamycin, TG02, panobinostat, lestaurtinib, and GDC-0084 as promising compounds for the treatment of central nervous system infections caused by the free-living amebae Naegleria, Acanthamoeba and Balamuthia. PMID:31707263

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  Predicting Synergism of Cancer Drug Combinations Using NCI-ALMANAC Data. PMID:31380352

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  The ReFRAME library as a comprehensive drug repurposing library to identify mammarenavirus inhibitors. PMID:31302150

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drug discovery

metasource: bio.tools
version: extracted_at: 2022-11-04T11:26:36.844554

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small molecules

metasource: bio.tools
version: extracted_at: 2022-11-04T11:26:36.844554

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drug metabolism

metasource: bio.tools
version: extracted_at: 2022-11-04T11:26:36.844554

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safety sciences

metasource: bio.tools
version: extracted_at: 2022-11-04T11:26:36.844554

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drug development

metasource: bio.tools
version: extracted_at: 2022-11-04T11:26:36.844554

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drug discovery small molecule drug metabolism safety sciences drug development