R31NJMRG last accessed: 2022-11-04

IUPHAR-DB
metasource: bio.tools
version: extracted_at: 2022-11-04T11:35:58.708643

iuphar-db
metasource: bio.tools
version: extracted_at: 2022-11-04T11:35:58.708643

Other names: Guide to Pharmacology, IUPHAR/BPS Guide to Pharmacology, GtoPdb, IUPHAR-DB, iuphar-db

The information in the database is presented at two levels: the initial view or landing pages for each target family provide expert-curated overviews of the key properties and selective ligands and tool compounds available. For selected targets more detailed introductory chapters for each family are available along with curated information on the pharmacological, physiological, structural, genetic and pathophysiogical properties of each target. Recent extensions to the database provide specific portals for accessing data on immunopharmacology (IUPHAR Guide to IMMUNOPHARMACOLOGY; www.guidetoimmunopharmacology.org), and on malaria pharmacology (IUPHAR/MMV Guide to MALARIA PHARMACOLOGY; www.guidetomalariapharmacology.org). The database is enhanced with hyperlinks to additional information in other databases including Ensembl, UniProt, PubChem and ChEMBL, as well as curated chemical information and literature citations in PubMed.

Webpage:

https://www.guidetopharmacology.org

Licence:

Name: IUPHAR/BPS Guide to PHARMACOLOGY Attribution required
URL: https://www.guidetopharmacology.org/citing.jsp

Publications: (6)

Publications
More detailed information about this field from each metasource.

The IUPHAR/BPS Guide to PHARMACOLOGY in 2018: updates and expansion to encompass the new guide to IMMUNOPHARMACOLOGY
PMID: 29149325
metasource: Fairsharing.org
version: FAIRsharing.org: Guide to Pharmacology; IUPHAR/BPS Guide to PHARMACOLOGY; DOI: https://doi.org/10.25504/FAIRsharing.f1dv0; Last edited: June 22, 2021, 11:57 a.m.; Last accessed: Jan 03 2022 7:06 p.m.

The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands
PMID: 26464438
metasource: Fairsharing.org
version: FAIRsharing.org: Guide to Pharmacology; IUPHAR/BPS Guide to PHARMACOLOGY; DOI: https://doi.org/10.25504/FAIRsharing.f1dv0; Last edited: June 22, 2021, 11:57 a.m.; Last accessed: Jan 03 2022 7:06 p.m.

The IUPHAR/BPS Guide to PHARMACOLOGY: an expert-driven knowledgebase of drug targets and their ligands
PMID: 24234439
metasource: Fairsharing.org
version: FAIRsharing.org: Guide to Pharmacology; IUPHAR/BPS Guide to PHARMACOLOGY; DOI: https://doi.org/10.25504/FAIRsharing.f1dv0; Last edited: June 22, 2021, 11:57 a.m.; Last accessed: Jan 03 2022 7:06 p.m.

The IUPHAR/BPS Guide to PHARMACOLOGY in 2020: extending immunopharmacology content and introducing the IUPHAR/MMV Guide to MALARIA PHARMACOLOGY
PMID: 31691834
metasource: Fairsharing.org
version: FAIRsharing.org: Guide to Pharmacology; IUPHAR/BPS Guide to PHARMACOLOGY; DOI: https://doi.org/10.25504/FAIRsharing.f1dv0; Last edited: June 22, 2021, 11:57 a.m.; Last accessed: Jan 03 2022 7:06 p.m.

IUPHAR-DB: new receptors and tools for easy searching and visualization of pharmacological data
PMID: 21087994
metasource: bio.tools
version: extracted_at: 2022-11-04T11:35:58.708643

https://doi.org/10.1093/nar/gkv1037
metasource: Nucleic Acid Research database catalogue
version: extracted_at: 2022-11-04T11:16:25.468657

The IUPHAR/BPS Guide to PHARMACOLOGY in 2018: updates and expansion to encompass the new guide to IMMUNOPHARMACOLOGY PubMed citations: 1266.

1266 articles citing: The IUPHAR/BPS Guide to PHARMACOLOGY in 2018: updates and expansion to encompass the new guide to IMMUNOPHARMACOLOGY

The effect of substance P and its common in vivo-formed metabolites on MRGPRX2 and human mast cell activation. PMID:35904495
Acute retigabine-induced effects on myelinated motor axons in amyotrophic lateral sclerosis. PMID:35881020
Tetramisole is a new IK1 channel agonist and exerts IK1 -dependent cardioprotective effects in rats. PMID:35880674
Fenofibrate in primary sclerosing cholangitis; a randomized, double-blind, placebo-controlled trial. PMID:35822553
Differential effects of TRPM4 channel inhibitors on Guinea pig urinary bladder smooth muscle excitability and contractility: Novel 4-chloro-2-[2-(2-chloro-phenoxy)-acetylamino]-benzoic acid (CBA) versus classical 9-phenanthrol. PMID:35822549
Population pharmacokinetic of paracetamol and atorvastatin with co-administration of semaglutide. PMID:35799471
KNIME workflow for retrieving causal drug and protein interactions, building networks, and performing topological enrichment analysis demonstrated by a DILI case study. PMID:35692045
Comparison of methods and resources for cell-cell communication inference from single-cell RNA-Seq data. PMID:35680885
Involvement of β-adrenoceptors in the cardiovascular responses induced by selective adenosine A2A and A2B receptor agonists. PMID:35643970
PRECOGx: exploring GPCR signaling mechanisms with deep protein representations. PMID:35639758
EOS789, pan-phosphate transporter inhibitor, ameliorates the progression of kidney injury in anti-GBM-induced glomerulonephritis rats. PMID:35621227
Are thyrotropin-releasing hormone (TRH) and analog taltirelin viable reversal agents of opioid-induced respiratory depression? PMID:35621218
In vitro evaluation suggests fenfluramine and norfenfluramine are unlikely to act as perpetrators of drug interactions. PMID:35599347
In vitro evaluation of fenfluramine and norfenfluramine as victims of drug interactions. PMID:35599345
Hearing loss: The final frontier of pharmacology. PMID:35599339
Hypothesis: Amelioration of obesity-induced cognitive dysfunction via a lorcaserin-betahistine combination treatment. PMID:35599337
The efficacy and safety of fingolimod plus standardized treatment versus standardized treatment alone for acute ischemic stroke: A systematic review and meta-analysis. PMID:35585652
Endophenotype-based in silico network medicine discovery combined with insurance record data mining identifies sildenafil as a candidate drug for Alzheimer's disease. PMID:35572351
An open-label randomized study of the relative absorption of gastro-resistant risedronate taken fasted or with food versus immediate-release risedronate. PMID:35526121
The Many Faces of G Protein-Coupled Receptor 143, an Atypical Intracellular Receptor. PMID:35495622
Untargeted metabolomics identifies the potential role of monocarboxylate transporter 6 (MCT6/SLC16A5) in lipid and amino acid metabolism pathways. PMID:35466588
Impact of the mouse estrus cycle on cannabinoid receptor agonist-induced molecular and behavioral outcomes. PMID:35466560
Inhibition of epigenetic reader proteins by apabetalone counters inflammation in activated innate immune cells from Fabry disease patients receiving enzyme replacement therapy. PMID:35417091
Nucleoside analog GS-441524: pharmacokinetics in different species, safety, and potential effectiveness against Covid-19. PMID:35396928
Convergent selective signaling impairment exposes the pathogenicity of latrophilin-3 missense variants linked to inheritable ADHD susceptibility. PMID:35393556
A physiologically based pharmacokinetic model of clopidogrel in populations of European and Japanese ancestry: An evaluation of CYP2C19 activity. PMID:35307978
Analysis of capecitabine metabolites in conjunction with digital autoradiography in a murine model of pancreatic cancer suggests extensive drug penetration through the tumor. PMID:35257504
CRISPR/Cas9 unveils the dynamics of the endogenous µ-opioid receptors on neuronal cells under continuous opioid stimulation. PMID:35239244
The affinity and selectivity of α-adrenoceptor antagonists, antidepressants and antipsychotics for the human α2A, α2B, and α2C-adrenoceptors and comparison with human α1 and β-adrenoceptors. PMID:35224877
2-Deoxy-d-glucose induces deglycosylation of proinflammatory cytokine receptors and strongly reduces immunological responses in mouse models of inflammation. PMID:35212163
wSDTNBI: a novel network-based inference method for virtual screening. PMID:35211272
Alternative to animal experimentation in pharmacology teaching: Development and validation of an equivalent digital learning tool. PMID:35147294
The interacting physiology of COVID-19 and the renin-angiotensin-aldosterone system: Key agents for treatment. PMID:35106954
The effects of prolactin receptor blockade in a murine endometriosis interna model. PMID:35084123
Tapentadol shows lower intrinsic efficacy at µ receptor than morphine and oxycodone. PMID:35084120
Exploring determinants of agonist efficacy at the CB1 cannabinoid receptor: Analogues of the synthetic cannabinoid receptor agonist EG-018. PMID:35041297
"LONG COVID"-A hypothesis for understanding the biological basis and pharmacological treatment strategy. PMID:35029046
New insights into the role of melatonin in diabetic cardiomyopathy. PMID:35005848
Increased heroin intake and relapse vulnerability in intermittent relative to continuous self-administration: Sex differences in rats. PMID:34986504
M1 muscarinic receptor activation decreases alcohol consumption via a reduction in consummatory behavior. PMID:34962108
Evaluation of the clinical cardiac safety of pemigatinib, a fibroblast growth factor receptor inhibitor, in participants with advanced malignancies. PMID:34951522
Metopimazine is primarily metabolized by a liver amidase in humans. PMID:34918875
Evaluation of Kratom Opioid Derivatives as Potential Treatment Option for Alcohol Use Disorder. PMID:34803709
Zinc protoporphyrin binding to telomerase complexes and inhibition of telomerase activity. PMID:34747573
The IUPHAR/BPS guide to PHARMACOLOGY in 2022: curating pharmacology for COVID-19, malaria and antibacterials. PMID:34718737
Long-term antagonism and allosteric regulation of mu opioid receptors by the novel ligand, methocinnamox. PMID:34713624
Jadomycins: A potential chemotherapy for multi-drug resistant metastatic breast cancer. PMID:34708587
Dynamics of the QTc interval over a 24-h dose interval after start of intravenous ciprofloxacin or low-dose erythromycin administration in ICU patients. PMID:34697899
SoxE group transcription factor Sox8 promotes astrocytic differentiation of neural stem/precursor cells downstream of Nfia. PMID:34677001
Spinal glial cells in itch modulation. PMID:34677000
Nuclear receptors of NR1 and NR4 subfamilies in the regulation of microglial functions and pathology. PMID:34676987
Antibiotic use and associated factors in adult outpatients from 2000 to 2019. PMID:34664793
In vitro investigations into the roles of CYP450 enzymes and drug transporters in the drug interactions of zanubrutinib, a covalent Bruton's tyrosine kinase inhibitor. PMID:34664792
Chemoinformatic Study and In vitro Bioevaluation of Tc-99m-Labeled N-Acetyl Neuraminic Acid in C6 Glioma Cells: Potential Role as a Radionuclide Imaging Probe. PMID:34658550
Bioequivalence and food effect of a fixed-dose combination of macitentan and tadalafil: Adaptive design in the COVID-19 pandemic. PMID:34624174
Suppression of collagen IV alpha-2 subunit by prolyl hydroxylase domain inhibition via hypoxia-inducible factor-1 in chronic kidney disease. PMID:34617686
Benefits and adverse effects of sacubitril/valsartan in patients with chronic heart failure: A systematic review and meta-analysis. PMID:34617669
Histamine in cancer immunology and immunotherapy. Current status and new perspectives. PMID:34609067
Bacterial growth dynamics and pharmacokinetic-pharmacodynamic relationships of rifampicin and bedaquiline in BALB/c mice. PMID:34599506
Mizagliflozin, a selective SGLT1 inhibitor, improves vascular cognitive impairment in a mouse model of small vessel disease. PMID:34586752
Specific Engineered G Protein Coupling to Histamine Receptors Revealed from Cellular Assay Experiments and Accelerated Molecular Dynamics Simulations. PMID:34576210
Distinct Effects of Escitalopram and Vortioxetine on Astroglial L-Glutamate Release Associated with Connexin43. PMID:34576176
Network-Based Identification and Experimental Validation of Drug Candidates Toward SARS-CoV-2 via Targeting Virus-Host Interactome. PMID:34539756
LR Hunting: A Random Forest Based Cell-Cell Interaction Discovery Method for Single-Cell Gene Expression Data. PMID:34497635
Stability investigations of cytochrome P450 (CYP) enzymes immediately after death in a pig model support the applicability of postmortem hepatic CYP quantification. PMID:34478246
EVT-701 is a novel selective and safe mitochondrial complex 1 inhibitor with potent anti-tumor activity in models of solid cancers. PMID:34478236
A glutamate concentration-biased allosteric modulator potentiates NMDA-induced ion influx in neurons. PMID:34476911
Induced fit versus conformational selection: From rate constants to fluxes… and back to rate constants. PMID:34459109
Therapeutic Promises of Medicinal Plants in Bangladesh and Their Bioactive Compounds against Ulcers and Inflammatory Diseases. PMID:34371551
Human-induced pluripotent stem cell-derived cardiomyocytes: Cardiovascular properties and metabolism and pharmacokinetics of deuterated mexiletine analogs. PMID:34327875
Drug repurposing strategies of relevance for Parkinson's disease. PMID:34309236
Effects of fadolmidine, an α2 -adrenoceptor agonist, as an adjuvant to spinal bupivacaine on antinociception and motor function in rats and dogs. PMID:34302721
Insights into the molecular mechanisms of Huangqi decoction on liver fibrosis via computational systems pharmacology approaches. PMID:34301291
Spermidine and spermine exert protective effects within the lung. PMID:34289267
Testicular disposition of clofarabine in rats is dependent on equilibrative nucleoside transporters. PMID:34288585
Pharmacological hypotheses: Is acetaminophen selective in its cyclooxygenase inhibition? PMID:34278737
Novel G-CSF conjugated anionic globular dendrimer: Preparation and biological activity assessment. PMID:34269522
Ocular safety of repeated intravitreal injections of Carboplatin and Digoxin: A preclinical study on the healthy rabbits. PMID:34250764
Evaluating aminophylline and progesterone combination treatment to modulate contractility and labor-related proteins in pregnant human myometrial tissues. PMID:34223706
Sofosbuvir-based therapies in genotype 2 hepatitis C virus cirrhosis: A real-life experience with focus on ribavirin dose. PMID:34152088
Overall survival in metastatic melanoma correlates with pembrolizumab exposure and T cell exhaustion markers. PMID:34129290
p-cymene impairs SARS-CoV-2 and Influenza A (H1N1) viral replication: In silico predicted interaction with SARS-CoV-2 nucleocapsid protein and H1N1 nucleoprotein. PMID:34128351
Exploring the Food and Drug Administration's review and approval of Entresto (sacubitril/valsartan). PMID:34087050
Synthesis, in vitro bioassays, and computational study of heteroaryl nitazoxanide analogs. PMID:34086411
Pharmacokinetics and safety of TCMCB07, a melanocortin-4 antagonist peptide in dogs. PMID:34014033
Antipsychotic drugs elicit cytotoxicity in glioblastoma multiforme in a calcium-dependent, non-D2 receptor-dependent, manner. PMID:34003586
Subtype selective fluorescent ligands based on ICI 118,551 to study the human β2-adrenoceptor in CRISPR/Cas9 genome-edited HEK293T cells at low expression levels. PMID:34003582
Chemogenetic activation of central gastrin-releasing peptide-expressing neurons elicits itch-related scratching behavior in male and female mice. PMID:34000759
The diverse effects of brain glucagon-like peptide 1 receptors on ingestive behaviour. PMID:33990944
Inhibition of inflammatory pain and cough by a novel charged sodium channel blocker. PMID:33988876
Does atorvastatin therapy change the anti-Xa activity in xabans-treated patients with atrial fibrillation? PMID:33984191
Seeking the exclusive binding region of phenylalkylamine derivatives on human T-type calcium channels via homology modeling and molecular dynamics simulation approach. PMID:33984189
scConnect: a method for exploratory analysis of cell-cell communication based on single cell RNA sequencing data. PMID:33974001
Repeated exposure of house dust mite induces progressive airway inflammation in mice: Differential roles of CCL17 and IL-13. PMID:33929099
Picotamide inhibits a wide spectrum of agonist-induced smooth muscle contractions in porcine renal interlobar and coronary arteries. PMID:33929093
The 5-HT2C receptor as a therapeutic target for alcohol and methamphetamine use disorders: A pilot study in treatment-seeking individuals. PMID:33929084
Effects of omecamtiv mecarbil on failing human ventricular trabeculae and interaction with (-)-noradrenaline. PMID:33929079
Cannabidiol inhibits the skeletal muscle Nav1.4 by blocking its pore and by altering membrane elasticity. PMID:33836525
TLR4 pathway impairs synaptic number and cerebrovascular functions through astrocyte activation following traumatic brain injury. PMID:33830504
Cryo-EM structure of the human histamine H1 receptor/Gq complex. PMID:33828102
Effect of hepatic impairment on pharmacokinetics, safety, and tolerability of lemborexant. PMID:33822479
The antimicrobial effect behind Cannabis sativa. PMID:33822478
The Agonist Action of Alkylphenols on TRPA1 Relates to Their Effects on Membrane Lipid Order: Implications for TRPA1-Mediated Chemosensation. PMID:33806007
CCN5 activation by free or encapsulated EGCG is required to render triple-negative breast cancer cell viability and tumor progression. PMID:33745223
ZINC40099027 activates human focal adhesion kinase by accelerating the enzymatic activity of the FAK kinase domain. PMID:33715263
Mouse strain specificity of DAAO inhibitors-mediated antinociception. PMID:33710781
Casticin protected against neuronal injury and inhibited the TLR4/NF-κB pathway after middle cerebral artery occlusion in rats. PMID:33704926
Biological drug therapy for ocular angiogenesis: Anti-VEGF agents and novel strategies based on nanotechnology. PMID:33694304
Effect of severe renal impairment on pharmacokinetics, safety, and tolerability of lemborexant. PMID:33689224
Can rodent models elucidate the pathomechanisms of genetic epilepsy? PMID:33689168
Pharmacokinetics, safety, and immunogenicity of HLX03, an adalimumab biosimilar, compared with reference biologic in healthy Chinese male volunteers: Results of a randomized, double-blind, parallel-controlled, phase 1 study. PMID:33682358
Nobiletin ameliorates cardiac impairment and alleviates cardiac remodeling after acute myocardial infarction in rats via JNK regulation. PMID:33660406
Quantification of BNN27, a novel neuroprotective 17-spiroepoxy dehydroepiandrosterone derivative in the blood and retina of rodents, after single intraperitoneal administration. PMID:33638308
Drug-Target Interaction Prediction Based on Adversarial Bayesian Personalized Ranking. PMID:33628808
Nitrous oxide improves cardiovascular, respiratory, and thermal stability during prolonged isoflurane anesthesia in juvenile guinea pigs. PMID:33543602
Phase I evaluation of pharmacokinetics and tolerability of the HIV-1 maturation inhibitor GSK3640254 and dolutegravir in healthy adults. PMID:33533507
β-arrestin2 recruitment at the β2 adrenergic receptor: A luciferase complementation assay adapted for undergraduate training in pharmacology. PMID:33508174
Biological features, gene expression profile, and mechanisms of drug resistance of two- and three-dimensional hepatocellular carcinoma cell cultures. PMID:33486902
Transcriptome network analyses in human coronavirus infections suggest a rational use of immunomodulatory drugs for COVID-19 therapy. PMID:33482326
Dexmedetomidine ameliorates high-fat diet-induced nonalcoholic fatty liver disease by targeting SCD1 in obesity mice. PMID:33474802
A novel histone deacetylase 6 inhibitor improves myelination of Schwann cells in a model of Charcot-Marie-Tooth disease type 1A. PMID:33460073
Therapeutic approaches against coronaviruses acute respiratory syndrome. PMID:33378565
Targeting host cell proteases as a potential treatment strategy to limit the spread of SARS-CoV-2 in the respiratory tract. PMID:33369210
Phosphoproteomic identification of vasopressin-regulated protein kinases in collecting duct cells. PMID:33346914
Safety and nonclinical and clinical pharmacokinetics of PC945, a novel inhaled triazole antifungal agent. PMID:33340279
Gabapentin reduces painful bladder hypersensitivity in rats with lipopolysaccharide-induced chronic cystitis. PMID:33340266
Functional Complexes of Angiotensin-Converting Enzyme 2 and Renin-Angiotensin System Receptors: Expression in Adult but Not Fetal Lung Tissue. PMID:33339432
Sex-dependent effects of endocannabinoid modulation of conditioned fear extinction in rats. PMID:33314038
New information of dopaminergic agents based on quantum chemistry calculations. PMID:33299000
Exploring a Safety Signal of Antipsychotic-Associated Pneumonia: A Pharmacovigilance-Pharmacodynamic Study. PMID:33289848
Cannabinoid control of neurogenic inflammation. PMID:33289534
Identification of an irreversible PPARγ antagonist with potent anticancer activity. PMID:33280279
Psychedelic-assisted therapy for functional neurological disorders: A theoretical framework and review of prior reports. PMID:33280274
Activation of trace amine-associated receptor 1 selectively attenuates the reinforcing effects of morphine. PMID:33247948
Pharmacological characterisation of novel adenosine A3 receptor antagonists. PMID:33247159
Pan-cancer population pharmacokinetics and exposure-safety and -efficacy analyses of atezolizumab in patients with high tumor mutational burden. PMID:33241650
Evaluation of clinical and genetic factors in the population pharmacokinetics of carbamazepine. PMID:33217013
Synergism between Angiotensin receptors ligands: Role of Angiotensin-(1-7) in modulating AT2 R agonist response on nitric oxide in kidney cells. PMID:33197136
Sirt3 regulates adipogenesis and adipokine secretion via its enzymatic activity. PMID:33191653
Diversity of molecular targets and signaling pathways for CBD. PMID:33169541
Combinatorial expression of GPCR isoforms affects signalling and drug responses. PMID:33149304
Nucleotide analogues as inhibitors of SARS-CoV Polymerase. PMID:33124786
Allosteric modulation of adenosine A1 and cannabinoid 1 receptor signaling by G-peptides. PMID:33124765
Metabolite Sensing GPCRs: Promising Therapeutic Targets for Cancer Treatment? PMID:33113952
Insights into the mechanism of Arnebia euchroma on leukemia via network pharmacology approach. PMID:33109189
Context-Specific Striatal Astrocyte Molecular Responses Are Phenotypically Exploitable. PMID:33086039
A systematic review and meta-analysis of the use of renin-angiotensin system drugs and COVID-19 clinical outcomes: What is the evidence so far? PMID:33084232
Cell Development Deficiency and Gene Expression Dysregulation of Trisomy 21 Retina Revealed by Single-Nucleus RNA Sequencing. PMID:33072724
Identification and characterization of a novel adiponectin receptor agonist adipo anti-inflammation agonist and its anti-inflammatory effects in vitro and in vivo. PMID:32986862
Comprehensive assessment of side effects in COVID-19 drug pipeline from a network perspective. PMID:32971210
Effects of mavacamten on Ca2+ sensitivity of contraction as sarcomere length varied in human myocardium. PMID:32960449
Formyl peptide receptor type 2 agonists to kick-start resolution pharmacology. PMID:32954491
Metabolic effects of carvedilol through β-arrestin proteins: investigations in a streptozotocin-induced diabetes rat model and in C2C12 myoblasts. PMID:32931611
Comparative host-pathogen protein-protein interaction analysis of recent coronavirus outbreaks and important host targets identification. PMID:32914167
Bisphosphonates for delivering drugs to bone. PMID:32876338
Soluble ligands as drug targets. PMID:32873970
Activation of AT2 receptors prevents diabetic complications in female db/db mice by NO-mediated mechanisms. PMID:32851652
Anti-inflammatory and antiviral roles of hydrogen sulfide: Rationale for considering H2 S donors in COVID-19 therapy. PMID:32783196
Tales of 1,008 small molecules: phenomic profiling through live-cell imaging in a panel of reporter cell lines. PMID:32764586
Hypersensitivity to amphetamine's psychomotor and reinforcing effects in serotonin transporter knockout rats: Glutamate in the nucleus accumbens. PMID:32721055
Non-steroidal anti-inflammatory drugs, prostaglandins, and COVID-19. PMID:32700336
2-Hydroxypropyl-β-cyclodextrin reduces retinal cholesterol in wild-type and Cyp27a1-/- Cyp46a1-/- mice with deficiency in the oxysterol production. PMID:32698250
Sex-related differences in COVID-19 lethality. PMID:32698249
Nicotine increases alcohol self-administration in male rats via a μ-opioid mechanism within the mesolimbic pathway. PMID:32697329
Integrating the inputs that shape pancreatic islet hormone release. PMID:32694675
Targeting zinc metalloenzymes in coronavirus disease 2019. PMID:32671829
Cough as an adverse effect on inhalation pharmaceutical products. PMID:32668011
Immunoregulatory effects and therapeutic potential of vitamin D in multiple sclerosis. PMID:32668009
Populations of in silico myocytes and tissues reveal synergy of multiatrial-predominant K+ -current block in atrial fibrillation. PMID:32667679
Tackling COVID-19 infection through complement-targeted immunotherapy. PMID:32643798
Revealing the Activity of Trimeric G-proteins in Live Cells with a Versatile Biosensor Design. PMID:32634377
Translational engagement of lysophosphatidic acid receptor 1 in skin fibrosis: from dermal fibroblasts of patients with scleroderma to tight skin 1 mouse. PMID:32627178
Heterologous expression of concatenated nicotinic ACh receptors: Pros and cons of subunit concatenation and recommendations for construct designs. PMID:32627170
Interactions between cannabidiol and Δ9 -tetrahydrocannabinol in modulating seizure susceptibility and survival in a mouse model of Dravet syndrome. PMID:32608111
Translational approach to understanding momentary factors associated with alcohol consumption. PMID:32608068
Single-cell RNA sequencing reveals cell type- and artery type-specific vascular remodelling in male spontaneously hypertensive rats. PMID:32589721
Sensitization of glutamate receptor-mediated pain behaviour via nerve growth factor-dependent phosphorylation of transient receptor potential V1 under inflammatory conditions. PMID:32579702
A chalcone derivative, 1m-6, exhibits atheroprotective effects by increasing cholesterol efflux and reducing inflammation-induced endothelial dysfunction. PMID:32579243
Structural mechanism underlying primary and secondary coupling between GPCRs and the Gi/o family. PMID:32572026
Integrins meet complement: The evolutionary tip of an iceberg orchestrating metabolism and immunity. PMID:32562277
CB1 receptor-dependent desensitisation of TRPV1 channels contributes to the analgesic effect of dipyrone in sensitised primary sensory neurons. PMID:32562269
Multifunctional opioid receptor agonism and antagonism by a novel macrocyclic tetrapeptide prevents reinstatement of morphine-seeking behaviour. PMID:32562259
Spinal heat shock protein 27 participates in PDGFRβ-mediated morphine tolerance through PI3K/Akt and p38 MAPK signalling pathways. PMID:32559815
Mechanism of action of SNF472, a novel calcification inhibitor to treat vascular calcification and calciphylaxis. PMID:32557649
Harnessing inflammation resolving-based therapeutic agents to treat pulmonary viral infections: What can the future offer to COVID-19? PMID:32557557
The ventral pallidum and relapse in alcohol seeking. PMID:32557550
Transient stimulation of TRPV4-expressing keratinocytes promotes hair follicle regeneration in mice. PMID:32542737
Sirtuin 3-mediated deacetylation of acyl-CoA synthetase family member 3 by protocatechuic acid attenuates non-alcoholic fatty liver disease. PMID:32520409
Artesunate interacts with the vitamin D receptor to reverse sepsis-induced immunosuppression in a mouse model via enhancing autophagy. PMID:32520399
Pro-resolving mediator protectin D1 promotes epimorphic regeneration by controlling immune cell function in vertebrates. PMID:32520398
Effects of Carbamazepine, Lacosamide and Zonisamide on Gliotransmitter Release Associated with Activated Astroglial Hemichannels. PMID:32516974
Δ9 -Tetrahydrocannabinolic acid alleviates collagen-induced arthritis: Role of PPARγ and CB1 receptors. PMID:32510591
Recombinant thrombomodulin protects against LPS-induced acute respiratory distress syndrome via preservation of pulmonary endothelial glycocalyx. PMID:32497259
A lesson from a saboteur: High-MW kininogen impact in coronavirus-induced disease 2019. PMID:32497257
Ethaninidothioic acid (R5421) is not a selective inhibitor of platelet phospholipid scramblase activity. PMID:32496597
Silencing of spontaneous activity at α4β1/3δ GABAA receptors in hippocampal granule cells reveals different ligand pharmacology. PMID:32484592
Metformin mitigates gastrointestinal radiotoxicity and radiosensitises P53 mutation colorectal tumours via optimising autophagy. PMID:32472692
Engineered anti-inflammatory peptides inspired by mapping an evasin-chemokine interaction. PMID:32471866
6-Hydroxydopamine lesion and levodopa treatment modify the effect of buspirone in the substantia nigra pars reticulata. PMID:32464686
Animal models of mechanisms of SARS-CoV-2 infection and COVID-19 pathology. PMID:32462701
Evaluating drug targets through human loss-of-function genetic variation. PMID:32461653
Exploring microRNAs in diabetic chronic cutaneous ulcers: Regulatory mechanisms and therapeutic potential. PMID:32449793
Regulation of gene expression by MF63, a selective inhibitor of microsomal PGE synthase 1 (mPGES1) in human osteoarthritic chondrocytes. PMID:32449517
Upregulated and Hyperactivated Thalamic Connexin 43 Plays Important Roles in Pathomechanisms of Cognitive Impairment and Seizure of Autosomal Dominant Sleep-Related Hypermotor Epilepsy with S284L-Mutant α4 Subunit of Nicotinic ACh Receptor. PMID:32443400
The case for chronotherapy in Covid-19-induced acute respiratory distress syndrome. PMID:32442317
A rationale for targeting the P2X7 receptor in Coronavirus disease 19. PMID:32441783
Repositioning PARP inhibitors for SARS-CoV-2 infection(COVID-19); a new multi-pronged therapy for acute respiratory distress syndrome? PMID:32441764
N-benzhydryl quinuclidine compounds are a potent and Src kinase-independent inhibitor of NALCN channels. PMID:32436268
Heterogeneous expression of GABA receptor-like subunits LCCH3 and GRD reveals functional diversity of GABA receptors in the honeybee Apis mellifera. PMID:32436264
Antitumour peptide based on a protein derived from the horseshoe crab: CIGB-552 a promising candidate for cancer therapy. PMID:32436254
High glucose-mediated PICALM and mTORC1 modulate processing of amyloid precursor protein via endosomal abnormalities. PMID:32436237
Effect of selective IK,ACh inhibition by XAF-1407 in an equine model of tachypacing-induced persistent atrial fibrillation. PMID:32436234
Ethanol consumption and sedation are altered in mice lacking the glycine receptor α2 subunit. PMID:32436225
Open-channel blocking action of volatile anaesthetics desflurane and sevoflurane on human voltage-gated Kv 1.5 channel. PMID:32436224
Signalling, trafficking and glucoregulatory properties of glucagon-like peptide-1 receptor agonists exendin-4 and lixisenatide. PMID:32436216
Transgenic LQT2, LQT5, and LQT2-5 rabbit models with decreased repolarisation reserve for prediction of drug-induced ventricular arrhythmias. PMID:32436214
Adenosine A2A receptor antagonists: from caffeine to selective non-xanthines. PMID:32424811
Acute chloroquine poisoning: A comprehensive experimental toxicology assessment of the role of diazepam. PMID:32415690
Novel strategies in immune checkpoint inhibitor drug development: How far are we from the paradigm shift? PMID:32394468
Cyclic AMP in dendritic cells: A novel potential target for disease-modifying agents in asthma and other allergic disorders. PMID:32372523
Potential therapeutic targets and promising drugs for combating SARS-CoV-2. PMID:32368792
Redox à la carte: Novel chemogenetic models of heart failure. PMID:32368791
The hyperpolarization-activated cyclic nucleotide-gated 4 channel as a potential anti-seizure drug target. PMID:32364262
Population pharmacokinetics of regorafenib in solid tumours: Exposure in clinical practice considering enterohepatic circulation and food intake. PMID:32358822
Metabolic reprogramming by N-acetyl-seryl-aspartyl-lysyl-proline protects against diabetic kidney disease. PMID:32352559
Inflammation induces developmentally regulated sumatriptan inhibition of spinal synaptic transmission. PMID:32352556
Targeting Cancer Gene Dependencies with Anthrax-Mediated Delivery of Peptide Nucleic Acids. PMID:32348107
Structure-based discovery of CZL80, a caspase-1 inhibitor with therapeutic potential for febrile seizures and later enhanced epileptogenic susceptibility. PMID:32346861
nNOS-CAPON blockers produce anxiolytic effects by promoting synaptogenesis in chronic stress-induced animal models of anxiety. PMID:32343840
Cyanidin-3-O-glucoside improves non-alcoholic fatty liver disease by promoting PINK1-mediated mitophagy in mice. PMID:32343398
Transcriptomic analysis of pulmonary artery smooth muscle cells identifies new potential therapeutic targets for idiopathic pulmonary arterial hypertension. PMID:32337710
Cloning and characterization of the rat Slo3 (KCa 5.1) channel: From biophysics to pharmacology. PMID:32335912
Heat shock protein 90 inhibition and multi-target approach to maximize cardioprotection in ischaemic injury. PMID:32335899
Restoration of HDAC2 and Nrf2 by andrographolide overcomes corticosteroid resistance in chronic obstructive pulmonary disease. PMID:32335896
B1 and B2 kinin receptor blockade improves psoriasis-like disease. PMID:32335893
A hypothesis for pathobiology and treatment of COVID-19: The centrality of ACE1/ACE2 imbalance. PMID:32333398
Current pharmacological treatments for COVID-19: What's next? PMID:32329520
Cannabidiol improves survival and behavioural co-morbidities of Dravet syndrome in mice. PMID:32321192
Voltage modulates the effect of μ-receptor activation in a ligand-dependent manner. PMID:32297669
Guide to Immunopharmacology: a database to boost immunology education, research and therapy. PMID:32297319
Evaluation of the profiles of CB1 cannabinoid receptor signalling bias using joint kinetic modelling. PMID:32293708
An orally available hypoglycaemic peptide taken up by caveolae transcytosis displays improved hypoglycaemic effects and body weight control in db/db mice. PMID:32293707
Exploring occupancy of the histamine H3 receptor by pitolisant in humans using PET. PMID:32293706
Potential for pharmacokinetic interactions between Schisandra sphenanthera and bosutinib, but not imatinib: in vitro metabolism study combined with a physiologically-based pharmacokinetic modelling approach. PMID:32250458
Cardiorenal syndrome: Multi-organ dysfunction involving the heart, kidney and vasculature. PMID:32250449
Pharmacological Characterization of a Betaine/GABA Transporter 1 (BGT1) Inhibitor Displaying an Unusual Biphasic Inhibition Profile and Anti-seizure Effects. PMID:32248400
Activation of μ-opioid receptors by MT-45 (1-cyclohexyl-4-(1,2-diphenylethyl)piperazine) and its fluorinated derivatives. PMID:32246840
TAAR1 agonists attenuate extended-access cocaine self-administration and yohimbine-induced reinstatement of cocaine-seeking. PMID:32246467
Upregulated Connexin 43 Induced by Loss-of-Functional S284L-Mutant α4 Subunit of Nicotinic ACh Receptor Contributes to Pathomechanisms of Autosomal Dominant Sleep-Related Hypermotor Epilepsy. PMID:32235384
Exendin-4, a GLP-1 receptor agonist regulates retinal capillary tone and restores microvascular patency after ischaemia-reperfusion injury. PMID:32232832
Identification of endogenous 1-aminopyrene as a novel mediator of progressive chronic kidney disease via aryl hydrocarbon receptor activation. PMID:32219844
TMTpro reagents: a set of isobaric labeling mass tags enables simultaneous proteome-wide measurements across 16 samples. PMID:32203386
The constitutive androstane receptor and pregnane X receptor in the brain. PMID:32201941
Neuroprotection induced by dexpramipexole delays disease progression in a mouse model of progressive multiple sclerosis. PMID:32199028
SingleCellSignalR: inference of intercellular networks from single-cell transcriptomics. PMID:32196115
Wikidata as a knowledge graph for the life sciences. PMID:32180547
Differential hepatoprotective role of the cannabinoid CB1 and CB2 receptors in paracetamol-induced liver injury. PMID:32167157
Low-concentration DMSO accelerates skin wound healing by Akt/mTOR-mediated cell proliferation and migration in diabetic mice. PMID:32167156
Improved efficacy, tolerance, safety, and abuse liability profile of the combination of CR4056 and morphine over morphine alone in rodent models. PMID:32154915
Beneficial effects of paricalcitol on cardiac dysfunction and remodelling in a model of established heart failure. PMID:32154912
Source of dopamine in gastric juice and luminal dopamine-induced duodenal bicarbonate secretion via apical dopamine D2 receptors. PMID:32154577
Inhibition of erythropoietin-producing hepatoma receptor B4 (EphB4) signalling suppresses the vascularisation and growth of endometriotic lesions. PMID:32144768
How ACE inhibitors transformed the renin-angiotensin system. PMID:32144755
Direct inhibition of the TLR4/MyD88 pathway by geniposide suppresses HIF-1α-independent VEGF expression and angiogenesis in hepatocellular carcinoma. PMID:32144747
Critical role of OX40 in drug-induced acute liver injury. PMID:32133635
Disease pharmacokinetic-pharmacodynamic modelling in acute intermittent porphyria to support the development of mRNA-based therapies. PMID:32133631
Plasmin improves blood-gas barrier function in oedematous lungs by cleaving epithelial sodium channels. PMID:32133621
Activation of the MET receptor attenuates doxorubicin-induced cardiotoxicity in vivo and in vitro. PMID:32133617
Gonadal hormone-independent sex differences in GABAA receptor activation in rat embryonic hypothalamic neurons. PMID:32133616
The effects of acute and sustained cannabidiol dosing for seven days on the haemodynamics in healthy men: A randomised controlled trial. PMID:32128848
Regulation of ICa,L and force by PDEs in human-induced pluripotent stem cell-derived cardiomyocytes. PMID:32092149
Intraocular pressure fluctuation and neurodegeneration in the diabetic rat retina. PMID:32087615
OATP1A/1B, CYP3A, ABCB1, and ABCG2 limit oral availability of the NTRK inhibitor larotrectinib, while ABCB1 and ABCG2 also restrict its brain accumulation. PMID:32087611
A low MW inhibitor of CD44 dimerization for the treatment of glioblastoma. PMID:32080830
The effects of meclizine on motion sickness revisited. PMID:32077140
Precision therapy of 6-mercaptopurine in Chinese children with acute lymphoblastic leukaemia. PMID:32077136
Population pharmacokinetics, efficacy, and safety of moxetumomab pasudotox in patients with relapsed or refractory hairy cell leukaemia. PMID:32077130
Cannabidiol protects against high glucose-induced oxidative stress and cytotoxicity in cardiac voltage-gated sodium channels. PMID:32077098
Inhibition of fatty acid amide hydrolase in the CNS prevents and reverses morphine tolerance in male and female mice. PMID:32077093
Population pharmacokinetics and Bayesian estimators for intravenous mycophenolate mofetil in haematopoietic stem cell transplant patients. PMID:32073158
Meprin-α (Mep1A) enhances TNF-α secretion by mast cells and aggravates abdominal aortic aneurysms. PMID:32072633
Effect of postdose fasting duration on hetrombopag olamine pharmacokinetics and pharmacodynamics in healthy volunteers. PMID:32069516
Effects of the dual sodium-glucose linked transporter inhibitor, licogliflozin vs placebo or empagliflozin in patients with type 2 diabetes and heart failure. PMID:32068914
Association between hydrochlorothiazide exposure and different incident skin, lip and oral cavity cancers: A series of population-based nested case-control studies. PMID:32068906
First-in-human study with ACT-539313, a novel selective orexin-1 receptor antagonist. PMID:32067262
A semi-mechanistic model based on glutathione depletion to describe intra-individual reduction in busulfan clearance. PMID:32067250
Pharmacokinetics, pharmacodynamics and safety of the inverse retinoic acid-related orphan receptor γ agonist AZD0284. PMID:32067249
Implication of in vivo circulating fibrocytes ablation in experimental pulmonary hypertension murine model. PMID:32060903
Myeloid-specific dopamine D2 receptor signalling controls inflammation in acute pancreatitis via inhibiting M1 macrophage. PMID:32060901
JQ1, a bromodomain inhibitor, suppresses Th17 effectors by blocking p300-mediated acetylation of RORγt. PMID:32060899
Functional marriage in plasma membrane: Critical cholesterol level-optimal protein activity. PMID:32060896
GPCRs in pancreatic adenocarcinoma: Contributors to tumour biology and novel therapeutic targets. PMID:32060895
The antiarrhythmic compound efsevin directly modulates voltage-dependent anion channel 2 by binding to its inner wall and enhancing mitochondrial Ca2+ uptake. PMID:32059260
Myocardial ischaemia reperfusion injury and cardioprotection in the presence of sensory neuropathy: Therapeutic options. PMID:32059259
Mitochondrial ion channels in pancreatic β-cells: Novel pharmacological targets for the treatment of Type 2 diabetes. PMID:32056196
Timing in drug absorption and disposition: The past, present, and future of chronopharmacokinetics. PMID:32056195
Morphine-induced respiratory depression is independent of β-arrestin2 signalling. PMID:32052419
Anatomical and single-cell transcriptional profiling of the murine habenular complex. PMID:32043968
Classification of Trispanins: A Diverse Group of Proteins That Function in Membrane Synthesis and Transport Mechanisms. PMID:32039202
Update of P2Y receptor pharmacology: IUPHAR Review 27. PMID:32037507
Vaccines targeting the primary amino acid sequence and conformational epitope of amyloid-β had distinct effects on neuropathology and cognitive deficits in EAE/AD mice. PMID:32034757
A 3-year prospective study of a multidisciplinary early proactive therapeutic drug monitoring programme of infliximab treatments in inflammatory bowel disease. PMID:32022291
Old dog, new trick: Trivalent arsenic as an immunomodulatory drug. PMID:32022256
Proteolysis-targeting chimeras in drug development: A safety perspective. PMID:32022252
IL-11 in cardiac and renal fibrosis: Late to the party but a central player. PMID:32022251
P2X7 receptor-targeted regulation by tetrahydroxystilbene glucoside in alcoholic hepatosteatosis: A new strategy towards macrophage-hepatocyte crosstalk. PMID:32022249
The IUPHAR Guide to Immunopharmacology: connecting immunology and pharmacology. PMID:32020584
Aurora kinase inhibitor tozasertib suppresses mast cell activation in vitro and in vivo. PMID:32017040
Pharmacological and genetic characterisation of the canine P2X4 receptor. PMID:32017039
Protective effect of cilastatin against diclofenac-induced nephrotoxicity through interaction with diclofenac acyl glucuronide via organic anion transporters. PMID:32000294
Endothelial cell and T-cell crosstalk: Targeting metabolism as a therapeutic approach in chronic inflammation. PMID:31999357
Cardioprotection in right heart failure. PMID:31995639
Anabolic androgenic steroid abuse in the United Kingdom: An update. PMID:31989581
Effect of hyperglycaemia and diabetes on acute myocardial ischaemia-reperfusion injury and cardioprotection by ischaemic conditioning protocols. PMID:31985828
Acetylshikonin suppressed growth of colorectal tumour tissue and cells by inhibiting the intracellular kinase, T-lymphokine-activated killer cell-originated protein kinase. PMID:31985814
Anti-αLβ2 antibodies reveal novel endocytotic cross-modulatory functionality. PMID:31985813
Functional expression and pharmacological modulation of TRPM3 in human sensory neurons. PMID:31985045
3D structure of the transporter ABCG2-What's new? PMID:31985041
An evaluation of the anti-hyperalgesic effects of cannabidiolic acid-methyl ester in a preclinical model of peripheral neuropathic pain. PMID:31981216
Tetramethylpyrazine: A promising drug for the treatment of pulmonary hypertension. PMID:31976548
Luteolin prevents irinotecan-induced intestinal mucositis in mice through antioxidant and anti-inflammatory properties. PMID:31976547
Cathelicidin-related antimicrobial peptide protects against ischaemia reperfusion-induced acute kidney injury in mice. PMID:31976546
100 years of modelling ligand-receptor binding and response: A focus on GPCRs. PMID:31975518
Overcoming tamoxifen resistance in oestrogen receptor-positive breast cancer using the novel thiosemicarbazone anti-cancer agent, DpC. PMID:31975484
C3a receptor antagonist therapy is protective with or without thrombolysis in murine thromboembolic stroke. PMID:31975437
Acid-sensing ion channel 3 blockade inhibits durovascular and nitric oxide-mediated trigeminal pain. PMID:31975427
Treatment with anti-neonatal Fc receptor (FcRn) antibody ameliorates experimental epidermolysis bullosa acquisita in mice. PMID:31975370
Scorpion toxin inhibits the voltage-gated proton channel using a Zn2+ -like long-range conformational coupling mechanism. PMID:31975366
Roflupram exerts neuroprotection via activation of CREB/PGC-1α signalling in experimental models of Parkinson's disease. PMID:31972868
HWL-088, a new potent free fatty acid receptor 1 (FFAR1) agonist, improves glucolipid metabolism and acts additively with metformin in ob/ob diabetic mice. PMID:31971610
Perfecting a high hypoxanthine phosphoribosyltransferase activity-uricase KO mice to test the effects of purine- and non-purine-type xanthine dehydrogenase (XDH) inhibitors. PMID:31971609
Opioid presynaptic disinhibition of the midbrain periaqueductal grey descending analgesic pathway. PMID:31971607
Inducible epithelial resistance against acute Sendai virus infection prevents chronic asthma-like lung disease in mice. PMID:31968123
Attenuation of fear-conditioned analgesia in rats by monoacylglycerol lipase inhibition in the anterior cingulate cortex: Potential role for CB2 receptors. PMID:31967664
Chronic inflammatory diseases, myocardial function and cardioprotection. PMID:31943142
GPCR and Alcohol-Related Behaviors in Genetically Modified Mice. PMID:31919661
Novel M2 -selective, Gi -biased agonists of muscarinic acetylcholine receptors. PMID:31910288
Adreno-melatonin receptor complexes control ion homeostasis and intraocular pressure - their disruption contributes to hypertensive glaucoma. PMID:31901203
Preclinical pharmacological evaluation of the fatty acid amide hydrolase inhibitor BIA 10-2474. PMID:31901141
Pathogenesis and pathophysiology of autosomal dominant sleep-related hypermotor epilepsy with S284L-mutant α4 subunit of nicotinic ACh receptor. PMID:31901135
Melatonin up-regulates bone marrow mesenchymal stem cells osteogenic action but suppresses their mediated osteoclastogenesis via MT2 -inactivated NF-κB pathway. PMID:31900938
Novel multifunctional iron chelators of the aroyl nicotinoyl hydrazone class that markedly enhance cellular NAD+ /NADH ratios. PMID:31895471
Modeling Neoadjuvant chemotherapy resistance in vitro increased NRP-1 and HER2 expression and converted MCF7 breast cancer subtype. PMID:31883395
The effects of anti-VEGF and kinin B1 receptor blockade on retinal inflammation in laser-induced choroidal neovascularization. PMID:31883121
Eucalyptol alleviates inflammation and pain responses in a mouse model of gout arthritis. PMID:31883118
Changes to the gut microbiota induced by losartan contributes to its antihypertensive effects. PMID:31883108
β-Caryophyllene, a dietary terpenoid, inhibits nicotine taking and nicotine seeking in rodents. PMID:31883107
Donecopride, a Swiss army knife with potential against Alzheimer's disease. PMID:31881553
Cell-permeable high-affinity tracers for Gq proteins provide structural insights, reveal distinct binding kinetics and identify small molecule inhibitors. PMID:31881095
Negative allosteric modulators of the human calcium-sensing receptor bind to overlapping and distinct sites within the 7-transmembrane domain. PMID:31881094
Different receptor mechanisms underlying phytocannabinoid- versus synthetic cannabinoid-induced tetrad effects: Opposite roles of CB1 /CB2 versus GPR55 receptors. PMID:31877572
Fulditoxin, representing a new class of dimeric snake toxins, defines novel pharmacology at nicotinic ACh receptors. PMID:31877243
Fluorescent ligands: Bringing light to emerging GPCR paradigms. PMID:31877233
Haemodynamic effects of the flavonoid quercetin in rats revisited. PMID:31877232
Identification, preclinical profile, and clinical proof of concept of an orally bioavailable pro-drug of miridesap. PMID:31877231
Interventions in the B-type natriuretic peptide signalling pathway as a means of controlling chronic itch. PMID:31877230
Novel approaches leading towards peptide GPCR de-orphanisation. PMID:31863461
Ageing, sex, and cardioprotection. PMID:31863453
Influence of mental stress and environmental toxins on circadian clocks: Implications for redox regulation of the heart and cardioprotection. PMID:31833063
Sequence-Derived Markers of Drug Targets and Potentially Druggable Human Proteins. PMID:31803227
Trends in use, pharmacology, and clinical applications of emerging herbal nutraceuticals. PMID:31799702
Emergency myelopoiesis contributes to immune cell exhaustion and pulmonary vascular remodelling. PMID:31793661
Imatinib, sunitinib and pazopanib: From flat-fixed dosing towards a pharmacokinetically guided personalized dose. PMID:31782166
Butyrate protects against high-fat diet-induced atherosclerosis via up-regulating ABCA1 expression in apolipoprotein E-deficiency mice. PMID:31769014
Hyperlipidaemia and cardioprotection: Animal models for translational studies. PMID:31769007
Inactivation of Cys674 in SERCA2 increases BP by inducing endoplasmic reticulum stress and soluble epoxide hydrolase. PMID:31758704
Ca2+ signalling in fibroblasts and the therapeutic potential of KCa3.1 channel blockers in fibrotic diseases. PMID:31758702
Naringenin attenuates non-alcoholic fatty liver disease by down-regulating the NLRP3/NF-κB pathway in mice. PMID:31758699
Morphine-induced RACK1-dependent autophagy in immortalized neuronal cell lines. PMID:31747048
Clinical relevance of St. John's wort drug interactions revisited. PMID:31742659
Paracetamol is a centrally acting analgesic using mechanisms located in the periaqueductal grey. PMID:31734950
Berberine protects against diabetic kidney disease via promoting PGC-1α-regulated mitochondrial energy homeostasis. PMID:31734944
Novel neuroactive steroid with hypnotic and T-type calcium channel blocking properties exerts effective analgesia in a rodent model of post-surgical pain. PMID:31732978
Off-label use of tacrolimus in children with glomerular disease: Effectiveness, safety and pharmacokinetics. PMID:31725919
Annexin-A1 deficiency exacerbates pathological remodelling of the mesenteric vasculature in insulin-resistant, but not insulin-deficient, mice. PMID:31724161
The nociceptin/orphanin FQ receptor system as a target to alleviate cancer-induced bone pain in rats: Model validation and pharmacological evaluation. PMID:31724155
PO-322 exerts potent immunosuppressive effects in vitro and in vivo by selectively inhibiting SGK1 activity. PMID:31724152
The brain-penetrating, orally bioavailable, ghrelin receptor agonist HM01 ameliorates motion-induced emesis in Suncus murinus (house musk shrew). PMID:31722444
The Second Gaddum Lecture: its origins and outcomes. PMID:31722438
The novel antipsychotic cariprazine stabilizes gamma oscillations in rat hippocampal slices. PMID:31722437
Established and emerging therapeutic uses of PDE type 5 inhibitors in cardiovascular disease. PMID:31721165
β3 Adrenoceptor-induced cholinergic inhibition in human and rat urinary bladders involves the exchange protein directly activated by cyclic AMP 1 favoring adenosine release. PMID:31721163
Erythropoietin accelerates the revascularization of transplanted pancreatic islets. PMID:31721150
NOP receptor antagonism reduces alcohol drinking in male and female rats through mechanisms involving the central amygdala and ventral tegmental area. PMID:31713848
Phosphatidylinositol 3-kinase-δ controls endoplasmic reticulum membrane fluidity and permeability in fungus-induced allergic inflammation in mice. PMID:31713846
Guanidine modifications enhance the anti-herpes simplex virus activity of (E,E)-4,6-bis(styryl)-pyrimidine derivatives in vitro and in vivo. PMID:31709511
Blockade of angiotensin AT1 receptors prevents arterial remodelling and stiffening in iron-overloaded rats. PMID:31705542
Prenatal and postnatal alcohol exposure increases vulnerability to cocaine addiction in adult mice. PMID:31705540
G protein-biased kratom-alkaloids and synthetic carfentanil-amide opioids as potential treatments for alcohol use disorder. PMID:31705528
Neuroanatomical correlates of the inhibition of tremulous jaw movements in rats by a combination of memantine and Δ9 -tetrahydrocannabinol. PMID:31696510
A new mechanism for cannabidiol in regulating the one-carbon cycle and methionine levels in Dictyostelium and in mammalian epilepsy models. PMID:31693171
Sex-based differences in the response to dexamethasone in bacterial meningitis: Analysis of the European dexamethasone in adulthood bacterial meningitis study. PMID:31692016
The virtually mature B-type natriuretic peptide (BNP1-32) is a precursor for the more effective BNP1-30. PMID:31691951
The IUPHAR/BPS Guide to PHARMACOLOGY in 2020: extending immunopharmacology content and introducing the IUPHAR/MMV Guide to MALARIA PHARMACOLOGY. PMID:31691834
Therapeutic target database 2020: enriched resource for facilitating research and early development of targeted therapeutics. PMID:31691823
The reactome pathway knowledgebase. PMID:31691815
Dietary fat and obesity as modulators of breast cancer risk: Focus on DNA methylation. PMID:31691272
Discovery of Human Signaling Systems: Pairing Peptides to G Protein-Coupled Receptors. PMID:31675498
Disrupted hepatic pentose phosphate pathway directly participates in and indirectly promotes CYP3A reduction: A new strategy for CYP3A-mediated drug hepatotoxicity. PMID:31670839
SIGNOR 2.0, the SIGnaling Network Open Resource 2.0: 2019 update. PMID:31665520
Unraveling allosteric landscapes of allosterome with ASD. PMID:31665428
A deadly trend in fentanyl fatalities (England, 1998-2017). PMID:31663152
Microbiota-dependent and -independent effects of dietary fibre on human health. PMID:31663129
Beclomethasone dipropionate, formoterol fumarate and glycopyrronium bromide: Synergy of triple combination therapy on human airway smooth muscle ex vivo. PMID:31660611
UDP-Glucuronosyltransferase (UGT)-mediated attenuations of cytochrome P450 3A4 activity: UGT isoform-dependent mechanism of suppression. PMID:31660580
Angiotensin-(1-7) mitigated angiotensin II-induced abdominal aortic aneurysms in apolipoprotein E-knockout mice. PMID:31658493
Rosiglitazone alleviates intrahepatic cholestasis induced by α-naphthylisothiocyanate in mice: The role of circulating 15-deoxy-Δ12,14 -PGJ2 and Nogo. PMID:31658492
Vasodilation of rat skeletal muscle arteries by the novel BK channel opener GoSlo is mediated by the simultaneous activation of BK and Kv 7 channels. PMID:31658366
Combining designer receptors exclusively activated by designer drugs and neuroimaging in experimental models: A powerful approach towards neurotheranostic applications. PMID:31658365
Icariside II, a phosphodiesterase 5 inhibitor, attenuates cerebral ischaemia/reperfusion injury by inhibiting glycogen synthase kinase-3β-mediated activation of autophagy. PMID:31658364
Sex-specific behavioural deficits induced at early life by prenatal exposure to the cannabinoid receptor agonist WIN55, 212-2 depend on mGlu5 receptor signalling. PMID:31658362
Carbonic anhydrase II does not regulate nitrite-dependent nitric oxide formation and vasodilation. PMID:31658361
Neurotrophic interactions between neurons and astrocytes following AAV1-Rheb(S16H) transduction in the hippocampus in vivo. PMID:31658360
The association of the optimal bolus of dexmedetomidine with its favourable haemodynamic outcomes in adult surgical patients under general anaesthesia. PMID:31656042
Mu and delta opioid receptors play opposite nociceptive and behavioural roles on nerve-injured mice. PMID:31655493
Novel highly potent OXE receptor antagonists with prolonged plasma lifetimes that are converted to active metabolites in vivo in monkeys. PMID:31655025
Inhibition of allergen-induced dermal eosinophilia by an oxoeicosanoid receptor antagonist in non-human primates. PMID:31655023
FOXO1 inhibition prevents renal ischemia-reperfusion injury via cAMP-response element binding protein/PPAR-γ coactivator-1α-mediated mitochondrial biogenesis. PMID:31655022
Long-lasting correction of in vivo LTP and cognitive deficits of mice modelling Down syndrome with an α5-selective GABAA inverse agonist. PMID:31652355
Role of phytochemicals as nutraceuticals for cognitive functions affected in ageing. PMID:31650528
Isoprenaline protects intestinal stem cells from chemotherapy-induced damage. PMID:31648381
Managing Parkinson's disease: moving ON with NOP. PMID:31648371
The enhanced immunopharmacology of VIB4920, a novel Tn3 fusion protein and CD40L antagonist, and assessment of its safety profile in cynomolgus monkeys. PMID:31648370
Propranolol is a mechanism-based inhibitor of CYP2D and CYP2D6 in humanized CYP2D6-transgenic mice: Effects on activity and drug responses. PMID:31648367
Antithrombotic effect of SP-8008, a benzoic acid derivative, through the selective inhibition of shear stress-induced platelet aggregation. PMID:31648364
A time-dependent contribution of hippocampal CB1 , CB2 and PPARγ receptors to cannabidiol-induced disruption of fear memory consolidation. PMID:31648363
ExonSkipDB: functional annotation of exon skipping event in human. PMID:31642488
Activation of oestrogen receptor α induces a novel form of LTP at hippocampal temporoammonic-CA1 synapses. PMID:31637699
Dietary antioxidants remodel DNA methylation patterns in chronic disease. PMID:31626338
A bivalent antihypertensive vaccine targeting L-type calcium channels and angiotensin AT1 receptors. PMID:31625597
Fenretinide treatment accelerates atherosclerosis development in apoE-deficient mice in spite of beneficial metabolic effects. PMID:31621898
Costunolide represses hepatic fibrosis through WW domain-containing protein 2-mediated Notch3 degradation. PMID:31621893
Enriching cancer pharmacology with drugs of marine origin. PMID:31621891
The effect of two selective A1 -receptor agonists and the bitopic ligand VCP746 on heart rate and regional vascular conductance in conscious rats. PMID:31596949
Opioids differentially modulate two synapses important for pain processing in the amygdala. PMID:31596498
Pituitary Adenylate Cyclase-Activating Polypeptide: 30 Years in Research Spotlight and 600 Million Years in Service. PMID:31540472
Isoniazid and host immune system interactions: A proposal for a novel comprehensive mode of action. PMID:31517993
Pharmacological targeting of β2 -adrenoceptors is neuroprotective in the LPS inflammatory rat model of Parkinson's disease. PMID:31506926
Chloroquine differentially modulates coronary vasodilation in control and diabetic mice. PMID:31503328
Fentanyl depression of respiration: Comparison with heroin and morphine. PMID:31499594
Functional contribution of sphingosine-1-phosphate to airway pathology in cigarette smoke-exposed mice. PMID:31499592
LL1, a novel and highly selective STAT3 inhibitor, displays anti-colorectal cancer activities in vitro and in vivo. PMID:31499589
Delayed intervention with a novel SGLT2 inhibitor NGI001 suppresses diet-induced metabolic dysfunction and non-alcoholic fatty liver disease in mice. PMID:31497874
Onion peel extract and its constituent, quercetin inhibits human Slo3 in a pH and calcium dependent manner. PMID:31496875
VARIDT 1.0: variability of drug transporter database. PMID:31495872
Inverse pharmacology: Approaches and tools for introducing druggability into engineered proteins. PMID:31494210
Hesperidin supplementation has no effect on blood glucose control: A systematic review and meta-analysis of randomized controlled clinical trials. PMID:31489695
Hospitalization as an opportunity to correct errors in anticoagulant treatment in patients with atrial fibrillation. PMID:31483510
Clinical value of analytical testing in patients presenting with new psychoactive substances intoxication. PMID:31483059
The effects of insecticides on two splice variants of the glutamate-gated chloride channel receptor of the major malaria vector, Anopheles gambiae. PMID:31479507
Relaxin reduces endothelium-derived vasoconstriction in hypertension: Revealing new therapeutic insights. PMID:31479151
Mechanisms underlying the inhibitory effects of probucol on elastase-induced abdominal aortic aneurysm in mice. PMID:31478560
Lasting effects of repeated ∆9 -tetrahydrocannabinol vapour inhalation during adolescence in male and female rats. PMID:31478558
Bronchodilation induced by PGE2 is impaired in Group III pulmonary hypertension. PMID:31476020
Population pharmacokinetics of sildenafil in extremely premature infants. PMID:31475367
A review of the prescribing trend of thiazide-type and thiazide-like diuretics in hypertension: A UK perspective. PMID:31471972
Toward a robust tool for pharmacokinetic-based personalization of treatment with tacrolimus in solid organ transplantation: A model-based meta-analysis approach. PMID:31471970
New drugs approved for acute myeloid leukaemia in 2018. PMID:31469910
The roles of gut microbiota and circadian rhythm in the cardiovascular protective effects of polyphenols. PMID:31465555
Connexin32 ameliorates renal fibrosis in diabetic mice by promoting K48-linked NADPH oxidase 4 polyubiquitination and degradation. PMID:31465542
Silencing of microRNA-494 inhibits the neurotoxic Th1 shift via regulating HDAC2-STAT4 cascade in ischaemic stroke. PMID:31465536
Impact of medicines regulatory risk communications in the UK on prescribing and clinical outcomes: Systematic review, time series analysis and meta-analysis. PMID:31465123
Resveratrol suppresses the myofibroblastic phenotype and fibrosis formation in kidneys via proliferation-related signalling pathways. PMID:31454852
CR4056, a powerful analgesic imidazoline-2 receptor ligand, inhibits the inflammation-induced PKCε phosphorylation and membrane translocation in sensory neurons. PMID:31454418
Δ8 -Tetrahydrocannabivarin has potent anti-nicotine effects in several rodent models of nicotine dependence. PMID:31454413
Binding site location on GABAA receptors determines whether mixtures of intravenous general anaesthetics interact synergistically or additively in vivo. PMID:31454409
Longitudinal exposure of English primary care patients to pharmacogenomic drugs: An analysis to inform design of pre-emptive pharmacogenomic testing. PMID:31454087
Dual inhibition of cannabinoid CB1 receptor and inducible NOS attenuates obesity-induced chronic kidney disease. PMID:31454063
Acupuncture alleviates acid- and purine-induced pain in rodents. PMID:31444978
The multifunctional peptide DN-9 produced peripherally acting antinociception in inflammatory and neuropathic pain via μ- and κ-opioid receptors. PMID:31444977
Considerations for improved performance of competition association assays analysed with the Motulsky-Mahan's "kinetics of competitive binding" model. PMID:31444916
Evidence for central antispastic effect of botulinum toxin type A. PMID:31444910
Characterisation of nerve-mediated ATP release from bladder detrusor muscle and its pathological implications. PMID:31430833
Co-morbidities and co-medications as confounders of cardioprotection-Does it matter in the clinical setting? PMID:31430831
Prescribing medicines to older people-How to consider the impact of ageing on human organ and body functions. PMID:31425638
Trichostatin A blocks aldosterone-induced Na+ transport and control of serum- and glucocorticoid-inducible kinase 1 in cortical collecting duct cells. PMID:31423568
Mind the gap (junction): cGMP induced by nitric oxide in cardiac myocytes originates from cardiac fibroblasts. PMID:31423565
NO and hepatocellular cancer. PMID:31423564
Methylphenidate and stuttering. PMID:31418914
Characterization of binding, functional activity, and contractile responses of the selective 5-HT1F receptor agonist lasmiditan. PMID:31418454
Praziquantel ameliorates CCl4 -induced liver fibrosis in mice by inhibiting TGF-β/Smad signalling via up-regulating Smad7 in hepatic stellate cells. PMID:31412137
In vitro determination of the efficacy of illicit synthetic cannabinoids at CB1 receptors. PMID:31412133
Inhibiting nucleolin reduces inflammation induced by mitochondrial DNA in cardiomyocytes exposed to hypoxia and reoxygenation. PMID:31412132
Role of the CLOCK protein in liver detoxification. PMID:31404943
Biological characterization of new inhibitors of microsomal PGE synthase-1 in preclinical models of inflammation and vascular tone. PMID:31404942
Polyethylene glycol loxenatide (PEX168) in subjects with renal impairment: A pharmacokinetic study. PMID:31396983
Modulation of the functions of myeloid-derived suppressor cells : a new strategy of hydrogen sulfide anti-cancer effects. PMID:31392723
Andrographolide alleviates Parkinsonism in MPTP-PD mice via targeting mitochondrial fission mediated by dynamin-related protein 1. PMID:31389613
Why is the therapeutic effect of acute antimigraine drugs delayed? A review of controlled trials and hypotheses about the delay of effect. PMID:31389059
The ellagitannin metabolite urolithin C is a glucose-dependent regulator of insulin secretion through activation of L-type calcium channels. PMID:31378934
Catalpol alleviates adriamycin-induced nephropathy by activating the SIRT1 signalling pathway in vivo and in vitro. PMID:31378931
Local controlled release of corticosteroids extends surgically induced joint instability by inhibiting tissue healing. PMID:31378925
Pterostilbene restores carbapenem susceptibility in New Delhi metallo-β-lactamase-producing isolates by inhibiting the activity of New Delhi metallo-β-lactamases. PMID:31376166
Heat sensing involves a TRiPlet of ion channels. PMID:31372975
Novel pharmacological actions of trequinsin hydrochloride improve human sperm cell motility and function. PMID:31368510
Natural compounds as potential adjuvants to cancer therapy: Preclinical evidence. PMID:31368509
Cannabichromene is a cannabinoid CB2 receptor agonist. PMID:31368508
A novel 2-aminobenzimidazole-based compound Jzu 17 exhibits anti-angiogenesis effects by targeting VEGFR-2 signalling. PMID:31368127
A non-covalent inhibitor XMU-MP-3 overrides ibrutinib-resistant BtkC481S mutation in B-cell malignancies. PMID:31364164
Population pharmacokinetics of pevonedistat alone or in combination with standard of care in patients with solid tumours or haematological malignancies. PMID:31355467
Modulation of μ-opioid receptor activation by acidic pH is dependent on ligand structure and an ionizable amino acid residue. PMID:31355457
No interactions between heparin and atacicept, an antagonist of B cell survival cytokines. PMID:31355456
Effects of the FGF receptor-1 inhibitor, infigratinib, with or without sildenafil, in experimental pulmonary arterial hypertension. PMID:31351013
Inhibition of the hyaluronan matrix enhances metabolic anticancer therapy by dichloroacetate in vitro and in vivo. PMID:31351004
Functional characterization of a novel opioid, PZM21, and its effects on the behavioural responses to morphine. PMID:31347704
Butyrate ameliorates caerulein-induced acute pancreatitis and associated intestinal injury by tissue-specific mechanisms. PMID:31347703
Lurasidone inhibits NMDA receptor antagonist-induced functional abnormality of thalamocortical glutamatergic transmission via 5-HT7 receptor blockade. PMID:31347694
Pharmacological basis and new insights of resveratrol action in the cardiovascular system. PMID:31347157
Effect of the novel histamine H4 receptor antagonist SENS-111 on spontaneous nystagmus in a rat model of acute unilateral vestibular loss. PMID:31347148
Nitric oxide signalling in the brain and its control of bodily functions. PMID:31347144
LUF7244, an allosteric modulator/activator of Kv 11.1 channels, counteracts dofetilide-induced torsades de pointes arrhythmia in the chronic atrioventricular block dog model. PMID:31339551
Myricanol modulates skeletal muscle-adipose tissue crosstalk to alleviate high-fat diet-induced obesity and insulin resistance. PMID:31339170
Sigma-1 receptor modulates neuroinflammation associated with mechanical hypersensitivity and opioid tolerance in a mouse model of osteoarthritis pain. PMID:31332781
The novel cannabinoid CB1 receptor agonist AM11101 increases food intake in female rats. PMID:31328790
Histamine up-regulates oncostatin M expression in human M1 macrophages. PMID:31328788
Pharmacological inhibition of Hippo pathway, with the novel kinase inhibitor XMU-MP-1, protects the heart against adverse effects during pressure overload. PMID:31328787
Ursolic acid promotes apoptosis and mediates transcriptional suppression of CT45A2 gene expression in non-small-cell lung carcinoma harbouring EGFR T790M mutations. PMID:31322286
Incidence of direct oral anticoagulant use in patients with nonvalvular atrial fibrillation and characteristics of users in 6 European countries (2008-2015): A cross-national drug utilization study. PMID:31318059
Therapeutic drug monitoring of infliximab in spondyloarthritis. A review of the literature. PMID:31315147
Involvement of d-amino acid oxidase in cerebral ischaemia induced by transient occlusion of the middle cerebral artery in mice. PMID:31309542
Stress granule: A promising target for cancer treatment. PMID:31301065
The effect of gastrectomy on regorafenib exposure and progression-free survival in patients with advanced gastrointestinal stromal tumours. PMID:31290566
Interactions of nanomaterials with ion channels and related mechanisms. PMID:31290152
What role does the (2R,6R)-hydronorketamine metabolite play in the antidepressant-like and abuse-related effects of (R)-ketamine? PMID:31288299
Potent, selective, and subunit-dependent activation of TRPC5 channels by a xanthine derivative. PMID:31277085
A novel and potent brain penetrant inhibitor of extracellular vesicle release. PMID:31273753
Mibefradil, a T-type Ca2+ channel blocker also blocks Orai channels by action at the extracellular surface. PMID:31271653
Tipping the scales: Are females more at risk for obesity- and high-fat diet-induced hypertension and vascular dysfunction? PMID:31271650
Drug-induced shortening of the electromechanical window is an effective biomarker for in silico prediction of clinical risk of arrhythmias. PMID:31271649
Repurposing drugs targeting the P2X7 receptor to limit hyperinflammation and disease during influenza virus infection. PMID:31271646
A phase I pharmacokinetic study of belinostat in patients with advanced cancers and varying degrees of liver dysfunction. PMID:31271459
An overview of the pharmacology of olive oil and its active ingredients. PMID:31270815
Evaluation and use of an anti-cynomolgus monkey CD79b surrogate antibody-drug conjugate to enable clinical development of polatuzumab vedotin. PMID:31270798
Nonlinear protein binding of phenytoin in clinical practice: Development and validation of a mechanistic prediction model. PMID:31269540
Low-dose ketamine provides poor analgesia for pain in redback spider envenoming. PMID:31269538
Comparative assessment of budesonide-MMX and mesalamine in active, mild-to-moderate ulcerative colitis: A systematic review and network meta-analysis. PMID:31269287
Dose-linearity of the pharmacokinetics of an intravenous [14 C]midazolam microdose in children. PMID:31269280
Impact of reduced P-glycoprotein function on digoxin concentrations in patients with dementia. PMID:31269278
Mitochondrial protection by simvastatin against angiotensin II-mediated heart failure. PMID:31265743
Distinct functions of endogenous cannabinoid system in alcohol abuse disorders. PMID:31265740
The role of smooth muscle cells in plaque stability: Therapeutic targeting potential. PMID:31254285
Structural Modification of the Antidepressant Mianserin Suggests That Its Anti-inflammatory Activity May Be Independent of 5-Hydroxytryptamine Receptors. PMID:31244825
Mediterranean diet and health status: Active ingredients and pharmacological mechanisms. PMID:31243760
Ibudilast attenuates doxorubicin-induced cytotoxicity by suppressing formation of TRPC3 channel and NADPH oxidase 2 protein complexes. PMID:31241172
Optimal route for administering tranexamic acid in primary unilateral total hip arthroplasty: Results from a multicenter cohort study. PMID:31236973
Altered cytochrome 2E1 and 3A P450-dependent drug metabolism in advanced ovarian cancer correlates to tumour-associated inflammation. PMID:31236938
Inhibitors of class I histone deacetylases attenuate thioacetamide-induced liver fibrosis in mice by suppressing hepatic type 2 inflammation. PMID:31236923
Salinomycin exerts anti-colorectal cancer activity by targeting the β-catenin/T-cell factor complex. PMID:31236922
The role of the gasotransmitter hydrogen sulfide in pathological calcification. PMID:31231793
Simultaneous phenotyping of CYP2E1 and CYP3A using oral chlorzoxazone and midazolam microdoses. PMID:31222796
Lovastatin attenuates hypertension induced by renal tubule-specific knockout of ATP-binding cassette transporter A1, by inhibiting epithelial sodium channels. PMID:31222723
Bcl-2/Bcl-xL inhibition predominantly synergistically enhances the anti-neoplastic activity of a low-dose CUSP9 repurposed drug regime against glioblastoma. PMID:31222722
Enhanced ATP release and CD73-mediated adenosine formation sustain adenosine A2A receptor over-activation in a rat model of Parkinson's disease. PMID:31220343
Intranasal administration of a stapled relaxin-3 mimetic has anxiolytic- and antidepressant-like activity in rats. PMID:31220339
Efficacy and toxicity of antihypertensive pharmacotherapy relative to effective dose 50. PMID:31219198
The impact of liver transplant recipient and donor genetic variability on tacrolimus exposure and transplant outcome. PMID:31219197
Appropriateness of prescription of oral anticoagulant therapy in acutely hospitalized older people with atrial fibrillation. Secondary analysis of the SIM-AF cluster randomized clinical trial. PMID:31218738
Prognostic significance of α- and β2-adrenoceptor gene expression in breast cancer patients. PMID:31218733
Adverse events reported for Mirena levonorgestrel-releasing intrauterine device in France and impact of media coverage. PMID:31218710
Opioid-sparing effects of cannabinoids on morphine analgesia: participation of CB1 and CB2 receptors. PMID:31218677
Natural Product Target Network Reveals Potential for Cancer Combination Therapies. PMID:31214023
Structural mechanisms underlying activation of TRPV1 channels by pungent compounds in gingers. PMID:31207668
Neutrophil extracellular trap-microparticle complexes trigger neutrophil recruitment via high-mobility group protein 1 (HMGB1)-toll-like receptors(TLR2)/TLR4 signalling. PMID:31206609
Ticagrelor and central sleep apnoea: Impact of withdrawal and reintroduction. PMID:31206207
Differences in CYP3A genotypes of a liver transplant recipient and the donor liver graft and adjustment of tacrolimus dose. PMID:31190414
The dual-functional memantine nitrate MN-08 alleviates cerebral vasospasm and brain injury in experimental subarachnoid haemorrhage models. PMID:31180578
Endothelial TRPV4 channels modulate vascular tone by Ca2+ -induced Ca2+ release at inositol 1,4,5-trisphosphate receptors. PMID:31177523
Effects of CYP3A inhibitors on the pharmacokinetics of quizartinib, a potent and selective FLT3 inhibitor, and its active metabolite. PMID:31173645
Paradoxical effects of exercise on hippocampal plasticity and cognition in mice with a heterozygous null mutation in the serotonin transporter gene. PMID:31167040
MicroRNA-29b-3p reduces intestinal ischaemia/reperfusion injury via targeting of TNF receptor-associated factor 3. PMID:31167039
Glucagon up-regulates hepatic mitochondrial pyruvate carrier 1 through cAMP-responsive element-binding protein; inhibition of hepatic gluconeogenesis by ginsenoside Rb1. PMID:31166615
Transcriptional profile of spinal dynorphin-lineage interneurons in the developing mouse. PMID:31166300
The plant product quinic acid activates Ca2+ -dependent mitochondrial function and promotes insulin secretion from pancreatic beta cells. PMID:31166006
Roles of organic anion transporter 2 and equilibrative nucleoside transporter 1 in hepatic disposition and antiviral activity of entecavir during non-pregnancy and pregnancy. PMID:31166004
Comparison of the ligand-binding properties of fluorescent VEGF-A isoforms to VEGF receptor 2 in living cells and membrane preparations using NanoBRET. PMID:31162634
Inhibition of polycomb repressor complex 2 ameliorates neointimal hyperplasia by suppressing trimethylation of H3K27 in vascular smooth muscle cells. PMID:31162630
Illuminating G-Protein-Coupling Selectivity of GPCRs. PMID:31160049
A Machine Learning Approach for the Discovery of Ligand-Specific Functional Mechanisms of GPCRs. PMID:31159491
Population pharmacokinetics of treosulfan in paediatric patients undergoing hematopoietic stem cell transplantation. PMID:31144349
Escitalopram population pharmacokinetics in people living with human immunodeficiency virus and in the psychiatric population: Drug-drug interactions and probability of target attainment. PMID:31144347
PPARδ agonist prevents endothelial dysfunction via induction of dihydrofolate reductase gene and activation of tetrahydrobiopterin salvage pathway. PMID:31144304
α7 nicotinic ACh receptors are necessary for memory recovery and neuroprotection promoted by attention training in amyloid-β-infused mice. PMID:31144293
PRECOG: PREdicting COupling probabilities of G-protein coupled receptors. PMID:31143927
Implementation and obstacles of pharmacogenetics in clinical practice: An international survey. PMID:31141189
Evaluation of covariate effects on pharmacokinetics of monoclonal antibodies in oncology. PMID:31140642
Adjusted indirect comparisons to assess bioequivalence between generic clopidogrel products in Serbia. PMID:31140620
Hydrogen sulfide lowers hyperhomocysteinemia dependent on cystathionine γ lyase S-sulfhydration in ApoE-knockout atherosclerotic mice. PMID:31140595
Pharmacology and function of the orphan GPR139 G protein-coupled receptor. PMID:31132229
Ca2+ signalling plays a role in celastrol-mediated suppression of synovial fibroblasts of rheumatoid arthritis patients and experimental arthritis in rats. PMID:31124139
Tanshinol borneol ester, a novel synthetic small molecule angiogenesis stimulator inspired by botanical formulations for angina pectoris. PMID:31116880
Acute activation of endothelial AMPK surprisingly inhibits endothelium-dependent hyperpolarization-like relaxations in rat mesenteric arteries. PMID:31116877
Non-sedating antihistamines block G-protein-gated inwardly rectifying K+ channels. PMID:31116876
Characterisation of P2Y2 receptors in human vascular endothelial cells using AR-C118925XX, a competitive and selective P2Y2 antagonist. PMID:31116875
Bouchardatine analogue alleviates non-alcoholic hepatic fatty liver disease/non-alcoholic steatohepatitis in high-fat fed mice by inhibiting ATP synthase activity. PMID:31113010
Effect of hepatic impairment on the pharmacokinetics of vilaprisan: An open-label, single-dose, parallel-group study. PMID:31112623
Nonlinear pharmacokinetics of rituximab in non-Hodgkin lymphomas: A pilot study. PMID:31112622
The importance of determining circadian parameters in pharmacological studies. PMID:31099023
Histidine-rich glycoprotein ameliorates endothelial barrier dysfunction through regulation of NF-κB and MAPK signal pathway. PMID:31093964
Sex differences in the hypothalamic-pituitary-adrenal axis: An obstacle to antidepressant drug development? PMID:31093959
GPCRomics: An Approach to Discover GPCR Drug Targets. PMID:31078319
Comparison of pharmacokinetics and the exposure-response relationship of dapagliflozin between adolescent/young adult and adult patients with type 1 diabetes mellitus. PMID:31077437
Spermidine-enhanced autophagic flux improves cardiac dysfunction following myocardial infarction by targeting the AMPK/mTOR signalling pathway. PMID:31077347
Exploring mitochondrial cholesterol signalling for therapeutic intervention in neurological conditions. PMID:31077345
Strain-selective efficacy of sacubitril/valsartan on carotid fibrosis in response to injury in two inbred mouse strains. PMID:31077344
Ursodeoxycholic acid accelerates bile acid enterohepatic circulation. PMID:31077342
Second M3 muscarinic receptor binding site contributes to bronchoprotection by tiotropium. PMID:31077341
The G-protein-biased agents PZM21 and TRV130 are partial agonists of μ-opioid receptor-mediated signalling to ion channels. PMID:31074038
Contribution of potassium channels to action potential repolarization of human embryonic stem cell-derived cardiomyocytes. PMID:31074016
Early toll-like receptor 4 blockade reduces ROS and inflammation triggered by microglial pro-inflammatory phenotype in rodent and human brain ischaemia models. PMID:31074003
Cartography of rhodopsin-like G protein-coupled receptors across vertebrate genomes. PMID:31064998
Molecular dynamics simulations of dihydro-β-erythroidine bound to the human α4β2 nicotinic acetylcholine receptor. PMID:31062355
Revealing Drug-Target Interactions with Computational Models and Algorithms. PMID:31052598
Hydrogen sulfide and dermatological diseases. PMID:31051046
Anomalous Kv 7 channel activity in human malignant hyperthermia syndrome unmasks a key role for H2 S and persulfidation in skeletal muscle. PMID:31051045
Antithrombotic dose: Some observations from published clinical trials. PMID:31050833
Pharmacokinetics, exposure, efficacy and safety of obinutuzumab in rituximab-refractory follicular lymphoma patients in the GADOLIN phase III study. PMID:31050355
Anticholinergic medicines use among older adults before and after initiating dementia medicines. PMID:31046175
Histamine, histamine receptors, and neuropathic pain relief. PMID:31046146
Blockade of the forward Na+ /Ca2+ exchanger suppresses the growth of glioblastoma cells through Ca2+ -mediated cell death. PMID:31034096
Inhibitors of DAG metabolism suppress CCR2 signalling in human monocytes. PMID:31032885
Efficacious dose of metformin for breast cancer therapy is determined by cation transporter expression in tumours. PMID:31032880
Histidine at position 462 determines the low quinine sensitivity of ether-à-go-go channel superfamily member Kv 12.1. PMID:31032878
Pharmacodynamics of rituximab on B lymphocytes in paediatric patients with autoimmune diseases. PMID:31026092
Analgesic efficacy and pharmacokinetics of epidural oxycodone in pain management after gynaecological laparoscopy-A randomised, double blind, active control, double-dummy clinical comparison with intravenous administration. PMID:31026086
Pharmacokinetic and pharmacodynamic modelling for renal function dependent urinary glucose excretion effect of ipragliflozin, a selective sodium-glucose cotransporter 2 inhibitor, both in healthy subjects and patients with type 2 diabetes mellitus. PMID:31026084
Hydrogen sulfide inhibits calcification of heart valves; implications for calcific aortic valve disease. PMID:31017307
The cholecystokinin receptor agonist, CCK-8, induces adiponectin production in rat white adipose tissue. PMID:31012948
Quantitative assessment of oligomeric amyloid β peptide binding to α7 nicotinic receptor. PMID:30981214
A photoswitchable GABA receptor channel blocker. PMID:30981211
Methadone and buprenorphine pharmacokinetics and pharmacodynamics when coadministered with fostemsavir to opioid-dependent, human immunodeficiency virus seronegative participants. PMID:30980734
Dynamics of circulating vascular endothelial growth factor-A predict benefit from antiangiogenic cediranib in metastatic or recurrent cervical cancer patients. PMID:30980733
Investigation of the absolute bioavailability and human mass balance of navoximod, a novel IDO1 inhibitor. PMID:30973970
Hepatic exposure of metformin in patients with non-alcoholic fatty liver disease. PMID:30973968
Blockade of myeloid differentiation 2 attenuates diabetic nephropathy by reducing activation of the renin-angiotensin system in mouse kidneys. PMID:30959575
Inhibition of STAT3 activation mediated by toll-like receptor 4 attenuates angiotensin II-induced renal fibrosis and dysfunction. PMID:30958891
Exposure-response modeling of tocilizumab in rheumatoid arthritis using continuous composite measures and their individual components. PMID:30958574
Cheminformatics Tools for Analyzing and Designing Optimized Small-Molecule Collections and Libraries. PMID:30956147
Sex as a biological variable in the pathology and pharmacology of neurodegenerative and neurovascular diseases. PMID:30950038
Model-free and kinetic modelling approaches for characterising non-equilibrium pharmacological pathway activity: Internalisation of cannabinoid CB1 receptors. PMID:30945265
Bradykinin increases BP in endotoxemic rat: functional and biochemical evidence of angiotensin II AT1 /bradykinin B2 receptor heterodimerization. PMID:30945263
Sulindac-derived retinoid X receptor-α modulator attenuates atherosclerotic plaque progression and destabilization in ApoE-/- mice. PMID:30943581
(R)-Ketamine exerts antidepressant actions partly via conversion to (2R,6R)-hydroxynorketamine, while causing adverse effects at sub-anaesthetic doses. PMID:30941749
Warfarin dose requirement in patients having severe thrombosis or thrombophilia. PMID:30933373
Stimulation of β-adrenoceptors up-regulates cardiac expression of galectin-3 and BIM through the Hippo signalling pathway. PMID:30932177
Inactivation of endothelial adenosine A2A receptors protects mice from cerebral ischaemia-induced brain injury. PMID:30931525
Short lipopeptides specifically inhibit the growth of Propionibacterium acnes with a dual antibacterial and anti-inflammatory action. PMID:30927447
Dried blood samples can support monitoring of infliximab concentrations in patients with inflammatory bowel disease: A clinical validation. PMID:30927375
Amlodipine induces vasodilation via Akt2/Sp1-activated miR-21 in smooth muscle cells. PMID:30927374
Oral administration of a new HRI activator as a new strategy to improve high-fat-diet-induced glucose intolerance, hepatic steatosis, and hypertriglyceridaemia through FGF21. PMID:30927369
Pathway genes and metabolites in thiopurine therapy in Korean children with acute lymphoblastic leukaemia. PMID:30927276
Action of MK-7264 (gefapixant) at human P2X3 and P2X2/3 receptors and in vivo efficacy in models of sensitisation. PMID:30927255
Analgesic transient receptor potential vanilloid-1-active compounds inhibit native and recombinant T-type calcium channels. PMID:30927254
Chemistry, pharmacology, and cellular uptake mechanisms of thiometallate sulfide donors. PMID:30924528
Influence of sildenafil on the purinergic components of nerve-mediated and urothelial ATP release from the bladder of normal and spinal cord injured mice. PMID:30924527
The potential of memory enhancement through modulation of perineuronal nets. PMID:30924524
VU0810464, a non-urea G protein-gated inwardly rectifying K+ (Kir 3/GIRK) channel activator, exhibits enhanced selectivity for neuronal Kir 3 channels and reduces stress-induced hyperthermia in mice. PMID:30924523
Therapeutic targeting of nuclear receptors, liver X and retinoid X receptors, for Alzheimer's disease. PMID:30924124
Antimycin A-induced mitochondrial dysfunction activates vagal sensory neurons via ROS-dependent activation of TRPA1 and ROS-independent activation of TRPV1. PMID:30914247
Perpetrator effects of ciclosporin (P-glycoprotein inhibitor) and its combination with fluconazole (CYP3A inhibitor) on the pharmacokinetics of rivaroxaban in healthy volunteers. PMID:30912163
Diabetes mellitus comorbidity in patients enrolled in tuberculosis drug efficacy trials around the world: A systematic review. PMID:30908689
Haematological adverse events associated with tyrosine kinase inhibitors in chronic myeloid leukaemia: A network meta-analysis. PMID:30907446
Relevance of CYP2B6 and CYP2D6 genotypes to methadone pharmacokinetics and response in the OPAL study. PMID:30907440
Beyond the Flavour: The Potential Druggability of Chemosensory G Protein-Coupled Receptors. PMID:30897734
Optostimulation of striatonigral terminals in substantia nigra induces dyskinesia that increases after L-DOPA in a mouse model of Parkinson's disease. PMID:30895594
Coadministration of the prostaglandin F2α receptor antagonist preterm labour drug candidate OBE022 with magnesium sulfate, atosiban, nifedipine and betamethasone. PMID:30891820
Pharmacokinetics and subjective effects of a novel oral LSD formulation in healthy subjects. PMID:30883864
Effects of cladribine tablets on heart rate, atrio-ventricular conduction and cardiac repolarization in patients with relapsing multiple sclerosis. PMID:30883839
Retinal and circulating miRNA expression patterns in diabetic retinopathy: An in silico and in vivo approach. PMID:30883703
Activation of Kv 7 channels as a novel mechanism for NO/cGMP-induced pulmonary vasodilation. PMID:30883701
Serelaxin enhances the therapeutic effects of human amnion epithelial cell-derived exosomes in experimental models of lung disease. PMID:30883698
Inhibition of phosphodiesterase-4 attenuates murine ulcerative colitis through interference with mucosal immunity. PMID:30883697
Impaired clearance of sunitinib leads to metabolic disorders and hepatotoxicity. PMID:30875096
Discovery of early life stress interacting and sex-specific quantitative trait loci impacting cocaine responsiveness. PMID:30874305
β3 -Adrenoceptor as a potential immuno-suppressor agent in melanoma. PMID:30874296
β3 -Adrenoceptors in the normal and diseased urinary bladder-What are the open questions? PMID:30868554
Role of obinutuzumab exposure on clinical outcome of follicular lymphoma treated with first-line immunochemotherapy. PMID:30866056
Androgen receptor antagonism accelerates disease onset in the SOD1G93A mouse model of amyotrophic lateral sclerosis. PMID:30849180
Protein inhibitor of activated STAT1 Ser503 phosphorylation-mediated Elk-1 SUMOylation promotes neuronal survival in APP/PS1 mice. PMID:30849179
Effects of proton pump inhibitors, esomeprazole and vonoprazan, on the disposition of proguanil, a CYP2C19 substrate, in healthy volunteers. PMID:30845361
A multiple methods approach to determine adherence with prescribed mycophenolate in children with kidney transplant. PMID:30845359
Effect of CYP3A inhibitors on the pharmacokinetics of pevonedistat in patients with advanced solid tumours. PMID:30845347
L-cysteine/cystathionine-β-synthase-induced relaxation in mouse aorta involves a L-serine/sphingosine-1-phosphate/NO pathway. PMID:30835815
A proof-of-concept, Phase 2 clinical trial of the gastrointestinal safety of a hydrogen sulfide-releasing anti-inflammatory drug. PMID:30834513
The specialised pro-resolving lipid mediator maresin 1 reduces inflammatory pain with a long-lasting analgesic effect. PMID:30830967
Enhanced responsiveness of platelets to vicagrel in IL-10-deficient mice through STAT3-dependent up-regulation of the hydrolase arylacetamide deacetylase in the intestine. PMID:30825385
Erucin exhibits vasorelaxing effects and antihypertensive activity by H2 S-releasing properties. PMID:30825379
Identification of the Raf kinase inhibitor TAK-632 and its analogues as potent inhibitors of necroptosis by targeting RIPK1 and RIPK3. PMID:30825190
Hypoxia modulates protein phosphatase 2A through HIF-1α dependent and independent mechanisms in human aortic smooth muscle cells and ventricular cardiomyocytes. PMID:30825189
Diosmetin induces apoptosis and enhances the chemotherapeutic efficacy of paclitaxel in non-small cell lung cancer cells via Nrf2 inhibition. PMID:30825187
Cyclic nucleotide signalling compartmentation by PDEs in cultured vascular smooth muscle cells. PMID:30825186
Small molecule-facilitated anion transporters in cells for a novel therapeutic approach to cystic fibrosis. PMID:30825185
Simvastatin protects photoreceptors from oxidative stress induced by all-trans-retinal, through the up-regulation of interphotoreceptor retinoid binding protein. PMID:30825184
S-nitrosoglutathione inhibits cerebrovascular angiotensin II-dependent and -independent AT1 receptor responses: A possible role of S-nitrosation. PMID:30822355
The proteostasis network provides targets for neurodegeneration. PMID:30820936
Metabolic control and sex: A focus on inflammatory-linked mediators. PMID:30820935
Adeno-associated virus-based Alzheimer's disease mouse models and potential new therapeutic avenues. PMID:30817847
The MC4 receptor agonist RO27-3225 inhibits NLRP1-dependent neuronal pyroptosis via the ASK1/JNK/p38 MAPK pathway in a mouse model of intracerebral haemorrhage. PMID:30811584
Interaction of OTC drug noscapine and acenocoumarol and phenprocoumon. PMID:30809820
Agonist-induced desensitisation of β3 -adrenoceptors: Where, when, and how? PMID:30809805
Molecular mechanisms of caffeine-mediated intestinal epithelial ion transports. PMID:30808064
Evidence for metabotropic function of epithelial nicotinic cholinergic receptors in rat colon. PMID:30807644
Progress in understanding mitochondrial calcium uniporter complex-mediated calcium signalling: A potential target for cancer treatment. PMID:30801705
Histamine, histamine H3 receptor, and alcohol use disorder. PMID:30801695
Signalling in response to sub-picomolar concentrations of active compounds: Pushing the boundaries of GPCR sensitivity. PMID:30801691
Adrenoceptors in white, brown, and brite adipocytes. PMID:30801689
Cardiac β3 -adrenoceptors-A role in human pathophysiology? PMID:30801686
Novel molecular mechanisms in the inhibition of adrenal aldosterone synthesis: Action of tolvaptan via vasopressin V2 receptor-independent pathway. PMID:30801659
From identification to functional characterization of cyriotoxin-1a, an antinociceptive toxin from the spider Cyriopagopus schioedtei. PMID:30784059
Handling interoccasion variability in model-based dose individualization using therapeutic drug monitoring data. PMID:30767254
Effects of dapagliflozin vs vildagliptin on cardiometabolic parameters in diabetic patients with coronary artery disease: a randomised study. PMID:30767253
Cannabinoid CB1 and CB2 receptor mechanisms underlie cannabis reward and aversion in rats. PMID:30767215
Modafinil protects hippocampal neurons by suppressing excessive autophagy and apoptosis in mice with sleep deprivation. PMID:30767208
Trehalose as a promising therapeutic candidate for the treatment of Parkinson's disease. PMID:30767205
Sex differences in mechanisms of arterial stiffness. PMID:30767200
A semiphysiological population pharmacokinetic model of agomelatine and its metabolites in Chinese healthy volunteers. PMID:30761579
Neprilysin inhibition for pulmonary arterial hypertension: a randomized, double-blind, placebo-controlled, proof-of-concept trial. PMID:30761523
Small-molecule inhibition of prostaglandin E receptor 2 impairs cyclooxygenase-associated malignant glioma growth. PMID:30761522
Bridging adults and paediatrics with secondary hyperparathyroidism receiving haemodialysis: a pharmacokinetic-pharmacodynamic analysis of cinacalcet. PMID:30756425
β-Adrenoceptor activation affects galectin-3 as a biomarker and therapeutic target in heart disease. PMID:30756388
Pharmacokinetics and pharmacodynamics of voxelotor (GBT440) in healthy adults and patients with sickle cell disease. PMID:30743314
Histamine in the kidneys: what is its role in renal pathophysiology? PMID:30741418
Five-year trends in acetaminophen use exceeding the recommended daily maximum dose. PMID:30740763
Cabozantinib-related cardiotoxicity: a prospective analysis in a real-world cohort of metastatic renal cell carcinoma patients. PMID:30740760
Adrenoceptor regulation of the mechanistic target of rapamycin in muscle and adipose tissue. PMID:30740664
Updates in the function and regulation of α1 -adrenoceptors. PMID:30740663
Microglial inflammation and phagocytosis in Alzheimer's disease: Potential therapeutic targets. PMID:30740661
The impact of dihydropyridine derivatives on the cerebral blood flow response to somatosensory stimulation and spreading depolarization. PMID:30737967
An osteoclastogenesis system, the RANKL/RANK signalling pathway, contributes to aggravated allergic inflammation. PMID:30737962
Patterns of gabapentin and pregabalin use and misuse: Results of a population-based cohort study in France. PMID:30737829
Semaphorin-3E attenuates intestinal inflammation through the regulation of the communication between splenic CD11C+ and CD4+ CD25- T-cells. PMID:30736100
Cannabinoids differentially modulate cortical information transmission through the sensorimotor or medial prefrontal basal ganglia circuits. PMID:30735570
GSK2646264, a spleen tyrosine kinase inhibitor, attenuates the release of histamine in ex vivo human skin. PMID:30735243
Pathology of white matter integrity in three major white matter fasciculi: A post-mortem study of schizophrenia and treatment status. PMID:30735241
Hydrogen sulfide regulates muscle RING finger-1 protein S-sulfhydration at Cys44 to prevent cardiac structural damage in diabetic cardiomyopathy. PMID:30734268
Population pharmacokinetic-pharmacodynamic modelling of the relationship between testosterone and prostate specific antigen in patients with prostate cancer during treatment with leuprorelin. PMID:30731514
Vasoactive intestinal peptide shapes first-trimester placenta trophoblast, vascular, and immune cell cooperation. PMID:30726565
Efficacy and safety of sapropterin dihydrochloride in patients with phenylketonuria: A meta-analysis of randomized controlled trials. PMID:30720885
What makes the α1A -adrenoceptor gene product assume an α1L -adrenoceptor phenotype? PMID:30719698
Inhibition of Cav 3.2 calcium channels: A new target for colonic hypersensitivity associated with low-grade inflammation. PMID:30714145
Function of cAMP scaffolds in obstructive lung disease: Focus on epithelial-to-mesenchymal transition and oxidative stress. PMID:30714124
Drug interactions with dementia-related pathophysiological pathways worsen or prevent dementia. PMID:30714122
The histidine decarboxylase model of tic pathophysiology: a new focus on the histamine H3 receptor. PMID:30714121
Mechanisms of hypertension in autoimmune rheumatic diseases. PMID:30714094
A novel cyclic biased agonist of the apelin receptor, MM07, is disease modifying in the rat monocrotaline model of pulmonary arterial hypertension. PMID:30710493
The δ-opioid receptor positive allosteric modulator BMS 986187 is a G-protein-biased allosteric agonist. PMID:30710458
Potent effects of dioscin against hepatocellular carcinoma through regulating TP53-induced glycolysis and apoptosis regulator (TIGAR)-mediated apoptosis, autophagy, and DNA damage. PMID:30710454
Central nervous system effects of the histamine-3 receptor antagonist CEP-26401, in comparison with modafinil and donepezil, after a single dose in a cross-over study in healthy volunteers. PMID:30710391
Targeting amyloid clearance in Alzheimer's disease as a therapeutic strategy. PMID:30710367
TMEM16A is implicated in the regulation of coronary flow and is altered in hypertension. PMID:30710335
Opposite effects of cannabinoid CB1 and CB2 receptors on antipsychotic clozapine-induced cardiotoxicity. PMID:30707759
Targeting the phosphorylation site of myristoylated alanine-rich C kinase substrate alleviates symptoms in a murine model of steroid-resistant asthma. PMID:30706455
Blockage of sphingosine-1-phosphate receptor 2 attenuates allergic asthma in mice. PMID:30706444
Loganetin protects against rhabdomyolysis-induced acute kidney injury by modulating the toll-like receptor 4 signalling pathway. PMID:30706443
Aspirin eugenol ester attenuates oxidative injury of vascular endothelial cells by regulating NOS and Nrf2 signalling pathways. PMID:30706438
Determinants of the interindividual variability in serum cytidine deaminase activity of patients with solid tumours. PMID:30701582
Pharmacokinetic herb-drug interaction between ginger and crizotinib. PMID:30701569
Relationship between allograft cyclosporin concentrations and P-glycoprotein expression in the 1st month following renal transplantation. PMID:30690767
Clinical trials, progression-speed differentiating features and swiftness rule of the innovative targets of first-in-class drugs. PMID:30689717
Pharmacological impact of antiretroviral therapy on platelet function to investigate human immunodeficiency virus-associated cardiovascular risk. PMID:30681136
Targeting the hepcidin-ferroportin pathway in anaemia of chronic kidney disease. PMID:30677788
Mitochondrial dysfunction in Alzheimer's disease: Role in pathogenesis and novel therapeutic opportunities. PMID:30675901
Lipid mediators in immune regulation and resolution. PMID:30674066
Neutralization of IL-17 rescues amyloid-β-induced neuroinflammation and memory impairment. PMID:30673121
Population pharmacokinetics of lenalidomide in patients with B-cell malignancies. PMID:30672004
Physiologically-based pharmacokinetics of ziprasidone in pregnant women. PMID:30669177
Discontinuation of medications at the end of life: A population study in Belgium, based on linked administrative databases. PMID:30667540
Effects of the nitric oxide synthase inhibitor ronopterin (VAS203) on renal function in healthy volunteers. PMID:30666700
Clinical and translational pharmacology of the cathepsin K inhibitor odanacatib studied for osteoporosis. PMID:30663085
Sex differences in schizophrenia, bipolar disorder, and post-traumatic stress disorder: Are gonadal hormones the link? PMID:30658014
1,2,3,4,6-Penta-O-galloyl-β-d-glucose modulates perivascular inflammation and prevents vascular dysfunction in angiotensin II-induced hypertension. PMID:30658013
A short perspective on the long road to effective treatments for Alzheimer's disease. PMID:30657599
Signalling by hydrogen sulfide and polysulfides via protein S-sulfuration. PMID:30657595
Spinal α2 -adrenoceptors and neuropathic pain modulation; therapeutic target. PMID:30657594
The β-secretase (BACE) inhibitor NB-360 in preclinical models: From amyloid-β reduction to downstream disease-relevant effects. PMID:30657591
Treasure troves of pharmacological tools to study transient receptor potential canonical 1/4/5 channels. PMID:30656647
Childhood adversity and mechanistic links to hypertension risk in adulthood. PMID:30656638
Domain insertion permissibility-guided engineering of allostery in ion channels. PMID:30655517
The citrus flavanone hesperetin preferentially inhibits slow-inactivating currents of a long QT syndrome type 3 syndrome Na+ channel mutation. PMID:30650182
Exposure-response analysis of blinatumomab in patients with relapsed/refractory acute lymphoblastic leukaemia and comparison with standard of care chemotherapy. PMID:30645768
Short lipopeptides specifically inhibit the growth of Propionibacterium acnes with dual antibacterial and anti-inflammatory action. PMID:30644534
3-Mercaptopyruvate sulfurtransferase supports endothelial cell angiogenesis and bioenergetics. PMID:30644090
Probe dependence of allosteric enhancers on the binding affinity of adenosine A1 -receptor agonists at rat and human A1 -receptors measured using NanoBRET. PMID:30644086
Don't forget astrocytes when targeting Alzheimer's disease. PMID:30636042
Betulinic acid alleviates endoplasmic reticulum stress-mediated nonalcoholic fatty liver disease through activation of farnesoid X receptors in mice. PMID:30635917
Optimising infliximab induction dosing for patients with ulcerative colitis. PMID:30634202
Neuroimmune nexus of depression and dementia: Shared mechanisms and therapeutic targets. PMID:30632147
Salvation of the fallen angel: Reactivating mutant p53. PMID:30632144
Treating Alzheimer's disease by targeting iron. PMID:30632143
Pterostilbene prevents hepatocyte epithelial-mesenchymal transition in fructose-induced liver fibrosis through suppressing miR-34a/Sirt1/p53 and TGF-β1/Smads signalling. PMID:30632134
Open-label study to evaluate trifluridine/tipiracil safety, tolerability and pharmacokinetics in patients with advanced solid tumours and hepatic impairment. PMID:30628113
Safety, tolerability, pharmacokinetics and effect on serum uric acid of the myeloperoxidase inhibitor AZD4831 in a randomized, placebo-controlled, phase I study in healthy volunteers. PMID:30618054
Ischaemic colitis associated with intravitreal administration of aflibercept: A first case report. PMID:30610744
Comprehensive identification of RNA-protein interactions in any organism using orthogonal organic phase separation (OOPS). PMID:30607034
Clinical and translational pharmacology of drugs for the prevention and treatment of bone metastases and cancer-induced bone loss. PMID:30601585
Systematic external evaluation of published population pharmacokinetic models of mycophenolate mofetil in adult kidney transplant recipients co-administered with tacrolimus. PMID:30597603
A dynamic and screening-compatible nanoluciferase-based complementation assay enables profiling of individual GPCR-G protein interactions. PMID:30593506
Epigenetic events involved in organic cation transporter 1-dependent impaired response of hepatocellular carcinoma to sorafenib. PMID:30592786
Effect of rifampin on enantioselective disposition and anti-hypertensive effect of benidipine. PMID:30589098
Stimulation of histamine H4 receptors increases the production of IL-9 in Th9 polarized cells. PMID:30589077
Modulation of α-adrenoceptor signalling protects photoreceptors after retinal detachment by inhibiting oxidative stress and inflammation. PMID:30588605
A novel nitroalkene-α-tocopherol analogue inhibits inflammation and ameliorates atherosclerosis in Apo E knockout mice. PMID:30588602
Activation of RyR2 by class I kinase inhibitors. PMID:30588601
Preclinical evaluation of [18 F]MA3: a CB2 receptor agonist radiotracer for PET. PMID:30588600
Kazinol U inhibits melanogenesis through the inhibition of tyrosinase-related proteins via AMP kinase activation. PMID:30579288
Gabapentin and pregabalin to treat aggressivity in dementia: a systematic review and illustrative case report. PMID:30575088
New steps in infliximab therapeutic drug monitoring in patients with inflammatory bowel diseases. PMID:30575085
Target engagement and cellular fate of otelixizumab: a repeat dose escalation study of an anti-CD3ε mAb in new-onset type 1 diabetes mellitus patients. PMID:30566758
Population pharmacokinetics of oral ivermectin in venous plasma and dried blood spots in healthy volunteers. PMID:30566757
Conference report: pharmacogenomics in special populations at WCP2018. PMID:30537134
Voriconazole hepatotoxicity as a result of steroid withdrawal in a patient with allergic bronchopulmonary aspergillosis. PMID:30537018
Antiresorptive agents' bone-protective and adjuvant effects in postmenopausal women with early breast cancer. PMID:30536446
Effect of inotuzumab ozogamicin on the QT interval in patients with haematologic malignancies using QTc-concentration modelling. PMID:30536405
Acute effects of zinc and insulin on arcuate anorexigenic proopiomelanocortin neurons. PMID:30521677
Particle size and gastrointestinal absorption influence tiotropium pharmacokinetics: a pilot bioequivalence study of PUR0200 and Spiriva HandiHaler. PMID:30521129
A clinical trial on the acute effects of methadone and buprenorphine on actual driving and cognitive function of healthy volunteers. PMID:30515857
The combination of metformin and 2-deoxyglucose significantly inhibits cyst formation in miniature pigs with polycystic kidney disease. PMID:30515768
Adjustment of the area under the concentration curve by terminal rate constant for bioequivalence assessment in a parallel-group study of lamotrigine. PMID:30511473
Therapeutic advances for blocking heterotopic ossification in fibrodysplasia ossificans progressiva. PMID:30501012
Systems analysis of phosphorylation-regulated Bcl-2 interactions establishes a model to reconcile the controversy over the significance of Bcl-2 phosphorylation. PMID:30500985
Hydrogen sulfide and hepatic lipid metabolism - a critical pairing for liver health. PMID:30499137
Xeroderma pigmentosum: overview of pharmacology and novel therapeutic strategies for neurological symptoms. PMID:30499105
Pharmacokinetics and pharmacodynamics of three dosages of oestriol after continuous vaginal ring administration for 21 days in healthy, postmenopausal women. PMID:30480330
Nightmares and hallucinations with aprepitant and opium powder: a suspected drug-drug interaction. PMID:30479035
Pharmacogenetics of artemether-lumefantrine influence on nevirapine disposition: Clinically significant drug-drug interaction? PMID:30471138
Clinical and translational pharmacological aspects of the management of fibrous dysplasia of bone. PMID:30471134
Hypoglycaemic effects of glimepiride in sulfonylurea receptor 1 deficient rat. PMID:30471094
β-Adrenoceptors as drug targets in melanoma: novel preclinical evidence for a role of β3 -adrenoceptors. PMID:30471093
Amyloid precursor protein-mediated mitochondrial regulation and Alzheimer's disease. PMID:30471088
The role of the histamine H4 receptor in atopic dermatitis and psoriasis. PMID:30460986
Exogenous IL-19 attenuates acute ischaemic injury and improves survival in male mice with myocardial infarction. PMID:30460984
Characterization of kinetics of human cytochrome P450s involved in bioactivation of flucloxacillin: inhibition of CYP3A-catalysed hydroxylation by sulfaphenazole. PMID:30447161
Regulation of heterologously expressed 5-HT1B receptors coupling to potassium channels in AtT-20 cells. PMID:30447001
The involvement of microglia in Alzheimer's disease: a new dog in the fight. PMID:30445661
Harnessing stem cells and biomaterials to promote neural repair. PMID:30444942
Pharmacological modulation of mitochondrial ion channels. PMID:30440086
Physiologically-based pharmacokinetic modelling to predict oprozomib CYP3A drug-drug interaction potential in patients with advanced malignancies. PMID:30428505
Ex vivo culture of cells derived from circulating tumour cell xenograft to support small cell lung cancer research and experimental therapeutics. PMID:30427531
Effectiveness and safety of 110 or 150 mg dabigatran vs. vitamin K antagonists in nonvalvular atrial fibrillation. PMID:30423205
Prolonged central apnoea after intravenous morphine administration in a 12-year-old male with a UGT1A1 loss-of-function polymorphism. PMID:30421550
Self-poisoning with 60 tablets of Apixaban, a pharmacokinetics case report. PMID:30421528
Once-daily darunavir/ritonavir 400/100 mg in triple therapy: efficacy and penetration in seminal compartment in ANRS-165 DARULIGHT study. PMID:30421447
Pharmacokinetic-pharmacodynamic modelling of platelet response to ticagrelor in stable coronary artery disease and prior myocardial infarction patients. PMID:30414387
Sirtuin 1 represses PKC-ζ activity through regulating interplay of acetylation and phosphorylation in cardiac hypertrophy. PMID:30414383
Mitochondrial protective effect of neferine through the modulation of nuclear factor erythroid 2-related factor 2 signalling in ischaemic stroke. PMID:30414381
Th1-type immune responses to Porphyromonas gingivalis antigens exacerbate angiotensin II-dependent hypertension and vascular dysfunction. PMID:30414380
Histamine receptors and cancer pharmacology: an update. PMID:30414378
The impact of tacrolimus exposure on extrarenal adverse effects in adult renal transplant recipients. PMID:30414331
Successful and safe long-term treatment of cerebral aspergillosis with high-dose voriconazole guided by therapeutic drug monitoring. PMID:30414213
FusionGDB: fusion gene annotation DataBase. PMID:30407583
Different mechanisms involved in liraglutide and glucagon-like peptide-1 vasodilatation in rat mesenteric small arteries. PMID:30403290
Nitric oxide synthase enzymology in the 20 years after the Nobel Prize. PMID:30402946
Predictors of first-year nonadherence and discontinuation of statins among older adults: a retrospective cohort study. PMID:30402916
NO as a multimodal transmitter in the brain: discovery and current status. PMID:30399649
Efficacy of DPP-4 inhibitors, GLP-1 analogues, and SGLT2 inhibitors as add-ons to metformin monotherapy in T2DM patients: a model-based meta-analysis. PMID:30394576
Prostaglandin-cytokine crosstalk in chronic inflammation. PMID:30381825
Oestradiol influences on dopamine release from the nucleus accumbens shell: sex differences and the role of selective oestradiol receptor subtypes. PMID:30381823
The role of vascular endothelium in nitroglycerin-mediated vasodilation. PMID:30378151
Anti-hyperlipidaemic effects of synthetic analogues of nordihydroguaiaretic acid in dyslipidaemic rats. PMID:30374952
DrugCentral 2018: an update. PMID:30371892
PubChem 2019 update: improved access to chemical data. PMID:30371825
Mitochondrial depolarization stimulates vascular repair-relevant functions of CD34+ cells via reactive oxygen species-induced nitric oxide generation. PMID:30367728
Pharmacokinetics and pharmacodynamics of ropinirole in patients with prolactinomas. PMID:30362146
Genetic approaches to metabolic bone diseases. PMID:30357886
Nitric oxide in the gastrointestinal tract: opportunities for drug development. PMID:30357812
BitterDB: taste ligands and receptors database in 2019. PMID:30357384
Network-Based Methods for Prediction of Drug-Target Interactions. PMID:30356768
Metabolism of sulfur compounds in homocystinurias. PMID:30341787
The affinity, intrinsic activity and selectivity of a structurally novel EP2 receptor agonist at human prostanoid receptors. PMID:30341781
The Developing Regorafenib Eye drops for neovascular Age-related Macular degeneration (DREAM) study: an open-label phase II trial. PMID:30341774
Histamine pharmacology: from Sir Henry Dale to the 21st century. PMID:30341770
Endothelial NOS: perspective and recent developments. PMID:30341769
Plasma extracellular nanovesicle (exosome)-derived biomarkers for drug metabolism pathways: a novel approach to characterize variability in drug exposure. PMID:30340248
Seselin ameliorates inflammation via targeting Jak2 to suppress the proinflammatory phenotype of macrophages. PMID:30338847
Preliminary evidence that vortioxetine may improve sleep quality in depressed patients with insomnia: a retrospective questionnaire analysis. PMID:30328132
Two-pore domain potassium channels: emerging targets for novel analgesic drugs: IUPHAR Review 26. PMID:30325008
Population pharmacokinetic modelling of intravenous paracetamol in fit older people displays extensive unexplained variability. PMID:30321459
Metformin produces anxiolytic-like effects in rats by facilitating GABAA receptor trafficking to membrane. PMID:30318707
The effect of indapamide vs. bendroflumethiazide for primary hypertension: a systematic review. PMID:30312512
Significantly lower CYP2D6 metabolism measured as the O/N-desmethylvenlafaxine metabolic ratio in carriers of CYP2D6*41 versus CYP2D6*9 or CYP2D6*10: a study on therapeutic drug monitoring data from 1003 genotyped Scandinavian patients. PMID:30312494
Targeting the extracellular matrix for delivery of bioactive molecules to sites of arthritis. PMID:30311636
Inhibitory effects of cycloastragenol on abdominal aortic aneurysm and its related mechanisms. PMID:30302749
Maternal paracetamol intake and fetal ductus arteriosus constriction or closure: a case series analysis. PMID:30300944
Immune cells in the tumour: new routes of retinoids for chemoprevention and chemotherapeutics. PMID:30298911
Cardiac effects of 6 months' dietary nitrate and spironolactone in patients with hypertension and with/at risk of type 2 diabetes, in the factorial design, double-blind, randomized controlled VaSera trial. PMID:30294825
Effects of sulfide and polysulfides transmitted by direct or signal transduction-mediated activation of TRPA1 channels. PMID:30292176
OSCP subunit of mitochondrial ATP synthase: role in regulation of enzyme function and of its transition to a pore. PMID:30291799
Inhaled nitric oxide. PMID:30288739
Special considerations for clinical trials in fibrodysplasia ossificans progressiva (FOP). PMID:30281842
Effects of maturation and size on population pharmacokinetics of pentoxifylline and its metabolites in very preterm infants with suspected late-onset sepsis or necrotizing enterocolitis: a pilot study incorporating clinical outcomes. PMID:30281170
Response to 'Comment on ''Massive' metformin overdose' by Chiew et al.'. PMID:30280392
First-time-in-human randomized clinical trial in healthy volunteers and haemodialysis patients with SNF472, a novel inhibitor of vascular calcification. PMID:30280390
Identification and pharmacological profile of SPP1, a potent, functionally selective and brain penetrant agonist at muscarinic M1 receptors. PMID:30276808
Nociceptin/Orphanin FQ (N/OFQ) conjugated to ATTO594: a novel fluorescent probe for the N/OFQ (NOP) receptor. PMID:30276802
Bioactive lipids and pathological retinal angiogenesis. PMID:30276789
Expression map of 78 brain-expressed mouse orphan GPCRs provides a translational resource for neuropsychiatric research. PMID:30271982
Hispaglabridin B, a constituent of liquorice identified by a bioinformatics and machine learning approach, relieves protein-energy wasting by inhibiting forkhead box O1. PMID:30270561
Nicotinic ACh receptor α7 inhibits PDGF-induced migration of vascular smooth muscle cells by activating mitochondrial deacetylase sirtuin 3. PMID:30270436
Adaptive immunity and IL-17A are not involved in the progression of chronic kidney disease after 5/6 nephrectomy in mice. PMID:30270435
Diethyldithiocarbamate, an anti-abuse drug, alleviates steatohepatitis and fibrosis in rodents through modulating lipid metabolism and oxidative stress. PMID:30266038
ABT-199 (Venetoclax), a BH3-mimetic Bcl-2 inhibitor, does not cause Ca2+ -signalling dysregulation or toxicity in pancreatic acinar cells. PMID:30266036
Hyperthermic intraperitoneal chemotherapy with oxaliplatin for peritoneal carcinomatosis: a clinical pharmacological perspective on a surgical procedure. PMID:30255585
Alcohol binge disrupts the rat intestinal barrier: the partial protective role of oleoylethanolamide. PMID:30248186
The impact of CYP2D6 mediated drug-drug interaction: a systematic review on a combination of metoprolol and paroxetine/fluoxetine. PMID:30248178
Single-cell RNA-seq reveals dynamic transcriptome profiling in human early neural differentiation. PMID:30239706
Three-dimensional electron microscopy techniques for unravelling mitochondrial dysfunction in heart failure and identification of new pharmacological targets. PMID:30225980
Lack of ethnic differences in the pharmacokinetics and pharmacodynamics of evolocumab between Caucasian and Asian populations. PMID:30225890
Disulfide reductase systems in liver. PMID:30221761
High-fructose corn syrup consumption in adolescent rats causes bipolar-like behavioural phenotype with hyperexcitability in hippocampal CA3-CA1 synapses. PMID:30221753
Adenosine A2A receptors facilitate synaptic NMDA currents in CA1 pyramidal neurons. PMID:30220081
Osteoanabolic and dual action drugs. PMID:30218587
Increased tacrolimus blood concentration by Beni-Madonna - a new hybrid citrus cultivar categorized as 'Tangor', in a liver transplant patient: likely furanocoumarin-mediated inhibition of CYP3A4 or P-glycoprotein. PMID:30218442
Pharmacological management of X-linked hypophosphataemia. PMID:30207609
Development of a physiologically based pharmacokinetic model for mefloquine and its application alongside a clinical effectiveness model to select an optimal dose for prevention of malaria in young Caucasian children. PMID:30198595
Complex decisions in the use of extracorporeal treatments in acute metformin overdose: which modality, when and how to measure the effect. PMID:30194775
Side effects of drugs for osteoporosis and metastatic bone disease. PMID:30192026
Rivaroxaban and macitentan can be coadministered without dose adjustment but the combination of rivaroxaban and St John's wort should be avoided. PMID:30192025
Therapeutic effects of bee venom and its major component, melittin, on atopic dermatitis in vivo and in vitro. PMID:30187459
Immunomodulatory tetracyclines shape the intestinal inflammatory response inducing mucosal healing and resolution. PMID:30184260
Reversal of albuminuria by combined AM6545 and perindopril therapy in experimental diabetic nephropathy. PMID:30184259
Zinc finger protein 91 positively regulates the production of IL-1β in macrophages by activation of MAPKs and non-canonical caspase-8 inflammasome. PMID:30182366
Therapeutic drug monitoring of tacrolimus and mycophenolic acid in outpatient renal transplant recipients using a volumetric dried blood spot sampling device. PMID:30176064
Effect of multiple-dose osimertinib on the pharmacokinetics of simvastatin and rosuvastatin. PMID:30171779
CYP3A4-mediated effects of rifampicin on the pharmacokinetics of vilaprisan and its UGT1A1-mediated effects on bilirubin glucuronidation in humans. PMID:30171692
Anti-IL-7 receptor α monoclonal antibody (GSK2618960) in healthy subjects - a randomized, double-blind, placebo-controlled study. PMID:30161291
Lisinopril-associated bullous pemphigoid in an elderly woman: a case report of a rare adverse drug reaction. PMID:30155951
Metabotropic Acetylcholine and Glutamate Receptors Mediate PI(4,5)P2 Depletion and Oscillations in Hippocampal CA1 Pyramidal Neurons in situ. PMID:30154490
Effects of levetiracetam on astroglial release of kynurenine-pathway metabolites. PMID:30153331
Angiotensin-converting enzyme inhibitor works as a scar formation inhibitor by down-regulating Smad and TGF-β-activated kinase 1 (TAK1) pathways in mice. PMID:30153328
Lysophosphatidic acid acts on LPA1 receptor to increase H2 O2 during flow-induced dilation in human adipose arterioles. PMID:30153326
The transient receptor potential melastatin 4 channel inhibitor 9-phenanthrol modulates cardiac sodium channel. PMID:30153324
Additional evidence for a therapeutic effect of dextromethorphan/quinidine on bulbar motor function in patients with amyotrophic lateral sclerosis: A quantitative speech analysis. PMID:30152872
3'-Sialyllactose as an inhibitor of p65 phosphorylation ameliorates the progression of experimental rheumatoid arthritis. PMID:30152858
Safety, tolerability, pharmacokinetics and pharmacokinetic-pharmacodynamic modelling of the novel H4 receptor inhibitor SENS-111 using a modified caloric test in healthy subjects. PMID:30152527
Understanding the tumour micro-environment communication network from an NOS2/COX2 perspective. PMID:30152521
Nitrite and nitrate chemical biology and signalling. PMID:30152056
Thioredoxin-related protein of 14 kDa as a modulator of redox signalling pathways. PMID:30129655
Brain histamine modulates recognition memory: possible implications in major cognitive disorders. PMID:30129226
Contribution of the commensal microbiota to atherosclerosis and arterial thrombosis. PMID:30129122
Nuciferine ameliorates hepatic steatosis in high-fat diet/streptozocin-induced diabetic mice through a PPARα/PPARγ coactivator-1α pathway. PMID:30129056
The bidirectional interaction between the sympathetic nervous system and immune mechanisms in the pathogenesis of hypertension. PMID:30129037
Cysteine residues in mitochondrial intermembrane space proteins: more than just import. PMID:30129023
The polyphenol resveratrol promotes skeletal growth in mice through a sirtuin 1-bone morphogenic protein 2 longevity axis. PMID:30125963
A smart algorithm for the prevention and risk management of QTc prolongation based on the optimized RISQ-PATH model. PMID:30112769
Neuronal histamine and the memory of emotionally salient events. PMID:30110713
Potentiation of the cystic fibrosis transmembrane conductance regulator by VX-770 involves stabilization of the pre-hydrolytic, O1 state. PMID:30107029
Opposing roles of CB1 and CB2 cannabinoid receptors in the stimulant and rewarding effects of cocaine. PMID:30101419
Efficacy of treprostinil in the SU5416-hypoxia model of severe pulmonary arterial hypertension: haemodynamic benefits are not associated with improvements in arterial remodelling. PMID:30098019
P2X7 as a scavenger receptor for innate phagocytosis in the brain. PMID:30098011
Inhibition of hyperpolarization-activated cyclic nucleotide-gated channels by β-blocker carvedilol. PMID:30098004
Therapeutic implications of how TNF links apolipoprotein E, phosphorylated tau, α-synuclein, amyloid-β and insulin resistance in neurodegenerative diseases. PMID:30097997
Inflammatory mediators: a causal link to hypertension during preeclampsia. PMID:30095157
Haem oxygenase-1 up-regulation by rosiglitazone via ROS-dependent Nrf2-antioxidant response elements axis or PPARγ attenuates LPS-mediated lung inflammation. PMID:30088830
Homeostatic impact of sulfite and hydrogen sulfide on cysteine catabolism. PMID:30088670
Challenges of Connecting Chemistry to Pharmacology: Perspectives from Curating the IUPHAR/BPS Guide to PHARMACOLOGY. PMID:30087946
SynPharm: A Guide to PHARMACOLOGY Database Tool for Designing Drug Control into Engineered Proteins. PMID:30087931
Proposed biosimilar pegfilgrastim shows similarity in pharmacokinetics and pharmacodynamics to reference pegfilgrastim in healthy subjects. PMID:30079636
Successful treatment of established heart failure in mice with recombinant HDL (Milano). PMID:30079544
Effects of systemic inhibitors of acid-sensing ion channels 1 (ASIC1) against acute and chronic mechanical allodynia in a rodent model of migraine. PMID:30079481
GpTx-1 and [Ala5 , Phe6 , Leu26 , Arg28 ]GpTx-1, two peptide NaV 1.7 inhibitors: analgesic and tolerance properties at the spinal level. PMID:30076786
Inhibition of histone deacetylase 7 reverses concentrative nucleoside transporter 2 repression in colorectal cancer by up-regulating histone acetylation state. PMID:30076612
Improving anticancer activity towards colon cancer cells with a new p53-activating agent. PMID:30076608
Effects of non-euphoric plant cannabinoids on muscle quality and performance of dystrophic mdx mice. PMID:30074247
Loop diuretics decrease the renal elimination rate and increase the plasma levels of trimethylamine-N-oxide. PMID:30069897
Nitric oxide and its role as a non-adrenergic, non-cholinergic inhibitory neurotransmitter in the gastrointestinal tract. PMID:30063800
17β-Estradiol reduces mitochondrial cAMP content and cytochrome oxidase activity in a phosphodiesterase 2-dependent manner. PMID:30051530
Stable isotope-labelled morphine to study in vivo central and peripheral morphine glucuronidation and brain transport in tolerant mice. PMID:30051501
Endocannabinoid regulation of homeostatic feeding and stress-induced alterations in food intake in male rats. PMID:30051485
DS-70, a novel and potent α4 integrin antagonist, is an effective treatment for experimental allergic conjunctivitis in guinea pigs. PMID:30051467
Icariin protects cardiomyocytes against ischaemia/reperfusion injury by attenuating sirtuin 1-dependent mitochondrial oxidative damage. PMID:30051466
Fingerprints of CNS drug effects: a plasma neuroendocrine reflection of D2 receptor activation using multi-biomarker pharmacokinetic/pharmacodynamic modelling. PMID:30051461
In vitro and in silico analysis of the effects of D2 receptor antagonist target binding kinetics on the cellular response to fluctuating dopamine concentrations. PMID:30051456
The signalling roles of sphingosine-1-phosphate derived from red blood cells and platelets. PMID:30047983
The association between the NAT2 genetic polymorphisms and risk of DILI during anti-TB treatment: a systematic review and meta-analysis. PMID:30047605
VCE-004.3, a cannabidiol aminoquinone derivative, prevents bleomycin-induced skin fibrosis and inflammation through PPARγ- and CB2 receptor-dependent pathways. PMID:30033591
Target site pharmacokinetics of doxycycline for rosacea in healthy volunteers is independent of the food effect. PMID:30033542
An alternative intermittent eltrombopag dosing protocol for the treatment of chronic immune thrombocytopenia. PMID:30032487
Glycycoumarin protects mice against acetaminophen-induced liver injury predominantly via activating sustained autophagy. PMID:30024038
Anti-tumour actions of cannabinoids. PMID:30019449
Population pharmacokinetics of serelaxin in patients with acute or chronic heart failure, hepatic or renal impairment, or portal hypertension and in healthy subjects. PMID:30014598
Calprotectin protects against experimental colonic inflammation in mice. PMID:30007036
Regulators of the transsulfuration pathway. PMID:30007014
Stimulation of brain nicotinic acetylcholine receptors activates adrenomedullary outflow via brain inducible NO synthase-mediated S-nitrosylation. PMID:30007012
Dual role of nitrergic neurotransmission in the bed nucleus of the stria terminalis in controlling cardiovascular responses to emotional stress in rats. PMID:30007000
Analgesic effects of ASP3662, a novel 11β-hydroxysteroid dehydrogenase 1 inhibitor, in rat models of neuropathic and dysfunctional pain. PMID:30006998
Proton pump inhibitors and Raynaud's phenomenon: is there a link? PMID:30003585
Model-based assessment of the benefits and risks of recombinant tissue plasminogen activator treatment in acute ischaemic stroke. PMID:30003573
A Computational Systems Pharmacology Approach to Investigate Molecular Mechanisms of Herbal Formula Tian-Ma-Gou-Teng-Yin for Treatment of Alzheimer's Disease. PMID:29997503
Allosteric and orthosteric pharmacology of cannabidiol and cannabidiol-dimethylheptyl at the type 1 and type 2 cannabinoid receptors. PMID:29981240
Angiotensin II, a stress-related neuropeptide in the CNS, facilitates micturition reflex in rats. PMID:29981238
Targeting toll-like receptor 4 signalling pathways: can therapeutics pay the toll for hypertension? PMID:29981161
β3 -Adrenoceptor stimulation of perivascular adipocytes leads to increased fat cell-derived NO and vascular relaxation in small arteries. PMID:29980164
Co-administration of proton pump inhibitors and/or of steroids may be a risk factor for low trough concentrations of posaconazole delayed-released tablets in adult patients with haematological malignancies. PMID:29975796
Increased risk of all-cause mortality associated with domperidone use in Parkinson's patients: a population-based cohort study in the UK. PMID:29975795
Mycophenolic acid concentrations in peripheral blood mononuclear cells are associated with the incidence of rejection in renal transplant recipients. PMID:29974488
Therapeutic drug monitoring-guided definition of adherence profiles in resistant hypertension and identification of predictors of poor adherence. PMID:29971815
Selegiline reduces adiposity induced by high-fat, high-sucrose diet in male rats. PMID:29971762
Hypertension: a new treatment for an old disease? Targeting the immune system. PMID:29969833
Metabolomic and lipidomic analysis of the effect of pioglitazone on hepatic steatosis in a rat model of obese Type 2 diabetes. PMID:29968381
Transmembrane member 16A participates in hydrogen peroxide-induced apoptosis by facilitating mitochondria-dependent pathway in vascular smooth muscle cells. PMID:29968377
Mitochondrial function in the heart: the insight into mechanisms and therapeutic potentials. PMID:29968316
Sex-specific autistic endophenotypes induced by prenatal exposure to valproic acid involve anandamide signalling. PMID:29968249
Thrombin modifies growth, proliferation and apoptosis of human colon organoids: a protease-activated receptor 1- and protease-activated receptor 4-dependent mechanism. PMID:29959891
Pharmacokinetics, metabolism and safety of deuterated L-DOPA (SD-1077)/carbidopa compared to L-DOPA/carbidopa following single oral dose administration in healthy subjects. PMID:29959802
Lopinavir/ritonavir treatment increases the placental transfer of bupivacaine enantiomers in human immunodeficiency virus-infected pregnant women. PMID:29959798
Effect of single and multiple doses of elobixibat, an ileal bile acid transporter inhibitor, on chronic constipation: A randomized controlled trial. PMID:29959787
Detecting a potential safety signal of antidepressants and type 2 diabetes: a pharmacovigilance-pharmacodynamic study. PMID:29953643
Cannabis contaminants: sources, distribution, human toxicity and pharmacologic effects. PMID:29953631
Identification of novel macropinocytosis inhibitors using a rational screen of Food and Drug Administration-approved drugs. PMID:29953580
MicroRNA-351-5p aggravates intestinal ischaemia/reperfusion injury through the targeting of MAPK13 and Sirtuin-6. PMID:29952043
Role of immune cells in hypertension. PMID:29952002
Antimicrobial endotoxin-neutralizing peptides promote keratinocyte migration via P2X7 receptor activation and accelerate wound healing in vivo. PMID:29947028
Activating the pregnane X receptor by imperatorin attenuates dextran sulphate sodium-induced colitis in mice. PMID:29945292
Prescription patterns of angiotensin-converting enzyme inhibitors for various indications: A UK population-based study. PMID:29943849
Pleural adverse drugs reactions and protein kinase inhibitors: Identification of suspicious targets by disproportionality analysis from VigiBase. PMID:29943846
A comparative pharmacokinetic study of DRL_BZ, a candidate biosimilar of bevacizumab, with Avastin® (EU and US) in healthy male subjects. PMID:29943831
Modulation of sonic hedgehog-induced mouse embryonic stem cell behaviours through E-cadherin expression and integrin β1-dependent F-actin formation. PMID:29933500
Reversal of dopamine-mediated firing inhibition through activation of the dopamine transporter in substantia nigra pars compacta neurons. PMID:29933497
Soluble syndecans: biomarkers for diseases and therapeutic options. PMID:29931674
Effect of tildrakizumab (MK-3222), a high affinity, selective anti-IL23p19 monoclonal antibody, on cytochrome P450 metabolism in subjects with moderate to severe psoriasis. PMID:29926968
MEDI0382, a GLP-1/glucagon receptor dual agonist, meets safety and tolerability endpoints in a single-dose, healthy-subject, randomized, Phase 1 study. PMID:29926478
Coadministration of probenecid and cimetidine with mirogabalin in healthy subjects: A phase 1, randomized, open-label, drug-drug interaction study. PMID:29920736
New drug controls and reduced hospital presentations due to novel psychoactive substances in Edinburgh. PMID:29911343
Newly developed serine protease inhibitors decrease visceral hypersensitivity in a post-inflammatory rat model for irritable bowel syndrome. PMID:29911328
Speciation of reactive sulfur species and their reactions with alkylating agents: do we have any clue about what is present inside the cell? PMID:29909607
Drug resistance profiles of mutations in the RET kinase domain. PMID:29908090
Glycyrrhizin has a high likelihood to be a victim of drug-drug interactions mediated by hepatic organic anion-transporting polypeptide 1B1/1B3. PMID:29908072
In vivo affinity and target engagement in skin and blood in a first-time-in-human study of an anti-oncostatin M monoclonal antibody. PMID:29900565
Noradrenaline up-regulates volume-regulated chloride current by PKA-independent cAMP/exchange protein activated by cAMP pathway in human atrial myocytes. PMID:29900525
A novel inhibitor of inducible NOS dimerization protects against cytokine-induced rat beta cell dysfunction. PMID:29888783
Activation of GPR55 increases neural stem cell proliferation and promotes early adult hippocampal neurogenesis. PMID:29888782
Monocytes as immune targets in arterial hypertension. PMID:29885051
Incidence and risk factors of major bleeding following major orthopaedic surgery with fondaparinux thromboprophylaxis. A time-to-event analysis. PMID:29877590
Gestational changes in buprenorphine exposure: A physiologically-based pharmacokinetic analysis. PMID:29873094
Long-term adverse effects of paracetamol - a review. PMID:29863746
Evolving treatment strategies in CML - moving from early and deep molecular responses to TKI discontinuation and treatment-free remission: is there a need for longer-term trial outcomes? PMID:29862545
A long-acting FGF21 alleviates hepatic steatosis and inflammation in a mouse model of non-alcoholic steatohepatitis partly through an FGF21-adiponectin-IL17A pathway. PMID:29859019
Tonantzitlolone is a nanomolar potency activator of transient receptor potential canonical 1/4/5 channels. PMID:29859013
Effects of cannabidiol plus naltrexone on motivation and ethanol consumption. PMID:29859012
Apolipoprotein E favours the blunting by high-fat diet of prostacyclin receptor activation in the mouse aorta. PMID:29859010
A recent history of nitroxyl chemistry, pharmacology and therapeutic potential. PMID:29859009
Quantitative systems pharmacology analysis of drug combination and scaling to humans: the interaction between noradrenaline and vasopressin in vasoconstriction. PMID:29859008
Safety, tolerability and pharmacokinetics/pharmacodynamics of the adrenomedullin antibody adrecizumab in a first-in-human study and during experimental human endotoxaemia in healthy subjects. PMID:29856470
The biomedical challenge of neurodegenerative disorders: an opportunity for cannabinoid-based therapies to improve on the poor current therapeutic outcomes. PMID:29856067
The emerging alliance of sphingosine-1-phosphate signalling and immune cells: from basic mechanisms to implications in hypertension. PMID:29856066
Vitamin D assays and the definition of hypovitaminosis D: results from the First International Conference on Controversies in Vitamin D. PMID:29851137
The phosphodiesterase 5 inhibitor, KJH-1002, reverses a mouse model of amnesia by activating a cGMP/cAMP response element binding protein pathway and decreasing oxidative damage. PMID:29847860
The prefrontal cortical endocannabinoid system modulates fear-pain interactions in a subregion-specific manner. PMID:29847859
Inflammasomes: a novel therapeutic target in pulmonary hypertension? PMID:29847700
A multiple treatment comparison meta-analysis of monoamine oxidase type B inhibitors for Parkinson's disease. PMID:29847694
Generation of a multi-functional, target organ-specific, anti-fibrotic molecule by molecular engineering of the extracellular matrix protein, decorin. PMID:29847688
The reaction of hydrogen sulfide with disulfides: formation of a stable trisulfide and implications for biological systems. PMID:29809282
Sulfite protects neurons from oxidative stress. PMID:29808913
Immune cell trafficking, lymphatics and hypertension. PMID:29797446
Effect of endocannabinoid signalling on cell fate: life, death, differentiation and proliferation of brain cells. PMID:29797438
The isothiocyanate sulforaphane modulates platelet function and protects against cerebral thrombotic dysfunction. PMID:29797311
PF-06526290 can both enhance and inhibit conduction through voltage-gated sodium channels. PMID:29791744
Interaction between ABCG2 421C>A polymorphism and valproate in their effects on steady-state disposition of lamotrigine in adults with epilepsy. PMID:29791014
The pharmacokinetics, pharmacodynamics and tolerability of PUR0200, a novel tiotropium formulation, in chronic obstructive pulmonary disease. PMID:29790581
The analgesic efficacy and pharmacokinetics of epidural oxycodone after gynaecological laparotomy: a randomized, double-blind, double-dummy comparison with intravenous administration. PMID:29782641
Drug-gut microbiota interactions: implications for neuropharmacology. PMID:29782640
Luteolin ameliorates rat myocardial ischaemia-reperfusion injury through activation of peroxiredoxin II. PMID:29782637
Modulation of serine/threonine phosphatases by melatonin: therapeutic approaches in neurodegenerative diseases. PMID:29781146
Platelets, autotaxin and lysophosphatidic acid signalling: win-win factors for cancer metastasis. PMID:29777586
Pharmacokinetics and C-reactive protein modelling of anti-interleukin-6 antibody (PF-04236921) in healthy volunteers and patients with autoimmune disease. PMID:29776017
Human monocyte transcriptional profiling identifies IL-18 receptor accessory protein and lactoferrin as novel immune targets in hypertension. PMID:29774543
Programmed necrosis in cardiomyocytes: mitochondria, death receptors and beyond. PMID:29774530
Inhibition of protein arginine methyltransferase 3 activity selectively impairs liver X receptor-driven transcription of hepatic lipogenic genes in vivo. PMID:29774529
Central adenosine A1 receptors inhibit cough via suppression of excitatory glutamatergic and tachykininergic neurotransmission. PMID:29767468
Salt, inflammation, IL-17 and hypertension. PMID:29767465
Hydrogen sulfide pathway and skeletal muscle: an introductory review. PMID:29767441
Pharmacokinetics of cefuroxime in infants and neonates undergoing cardiac surgery. PMID:29761538
Gjestad et al. reply to 'Was 4β-hydroxycholesterol ever going to be a useful marker of CYP3A4 activity?' by Neuhoff and Tucker. PMID:29749106
Persulfide synthases that are functionally coupled with translation mediate sulfur respiration in mammalian cells. PMID:29748969
Appropriateness of oral anticoagulant therapy prescription and its associated factors in hospitalized older people with atrial fibrillation. PMID:29745441
High exposure compared with standard exposure to metoclopramide associated with a higher risk of parkinsonism: a nationwide population-based cohort study. PMID:29745438
Arrhythmic hazard map for a 3D whole-ventricle model under multiple ion channel block. PMID:29745425
Moderate correlation between systemic IL-6 responses and CRP with trough concentrations of voriconazole. PMID:29744898
Targeting the dopamine D1 receptor or its downstream signalling by inhibiting phosphodiesterase-1 improves cognitive performance. PMID:29726015
A novel cross-species inhibitor to study the function of CatSper Ca2+ channels in sperm. PMID:29723408
High-frequency autonomic modulation: a new model for analysis of autonomic cardiac control. PMID:29723392
PEP06 polypeptide 30 exerts antitumour effect in colorectal carcinoma via inhibiting epithelial-mesenchymal transition. PMID:29722931
Tolerance to high-internalizing δ opioid receptor agonist is critically mediated by arrestin 2. PMID:29722902
LW106, a novel indoleamine 2,3-dioxygenase 1 inhibitor, suppresses tumour progression by limiting stroma-immune crosstalk and cancer stem cell enrichment in tumour micro-environment. PMID:29722898
The opioid oxycodone use-dependently inhibits the cardiac sodium channel NaV 1.5. PMID:29722437
Cigarette smoke up-regulates PDE3 and PDE4 to decrease cAMP in airway cells. PMID:29722436
Futility of current urine salbutamol doping control. PMID:29722428
Emerging disease-modifying strategies targeting α-synuclein for the treatment of Parkinson's disease. PMID:29722028
Hippocampal PPARα is a novel therapeutic target for depression and mediates the antidepressant actions of fluoxetine in mice. PMID:29722018
Statin use associated with lower risk of epilepsy after intracranial haemorrhage: A population-based cohort study. PMID:29714813
Divergent effects of strontium and calcium-sensing receptor positive allosteric modulators (calcimimetics) on human osteoclast activity. PMID:29714810
In Silico Pharmacoepidemiologic Evaluation of Drug-Induced Cardiovascular Complications Using Combined Classifiers. PMID:29712429
Pharmacokinetics, safety and tolerability of OBE022, a selective prostaglandin F2α receptor antagonist tocolytic: A first-in-human trial in healthy postmenopausal women. PMID:29708281
Cannabis, from plant to pill. PMID:29701252
Kuypers and Vanhove reply to 'Was 4β-hydroxycholesterol ever going to be a useful marker of CYP3A4 activity?' by Neuhoff and Tucker. PMID:29691891
Safe use of proton pump inhibitors in patients with cirrhosis. PMID:29688583
Single- and multiple-dose escalation study to assess pharmacokinetics, pharmacodynamics and safety of oral esaxerenone in healthy Japanese subjects. PMID:29688582
Cumulative exposure to phthalates from phthalate-containing drug products: a Danish population-wide study. PMID:29688578
The selective mineralocorticoid receptor antagonist eplerenone prevents decompensation of the liver in cirrhosis. PMID:29682743
Antinociception by the anti-oxidized phospholipid antibody E06. PMID:29679953
Novel inhibitors of the cellular renin-angiotensin system components, poricoic acids, target Smad3 phosphorylation and Wnt/β-catenin pathway against renal fibrosis. PMID:29679507
New paradigms in adenosine receptor pharmacology: allostery, oligomerization and biased agonism. PMID:29679502
PPARs and pain. PMID:29679493
Identification and structure elucidation of the pro-resolving mediators provides novel leads for resolution pharmacology. PMID:29679485
The role of autoimmune reactivity induced by heat shock protein 70 in the pathogenesis of essential hypertension. PMID:29679484
Prostaglandin FP receptor antagonists: discovery, pharmacological characterization and therapeutic utility. PMID:29679483
Regulation of vascular permeability in anaphylaxis. PMID:29671869
Inorganic hydrogen polysulfides: chemistry, chemical biology and detection. PMID:29669174
Prostaglandin analogues and nitric oxide contribution in the treatment of ocular hypertension and glaucoma. PMID:29669171
Galantamine is not a positive allosteric modulator of human α4β2 or α7 nicotinic acetylcholine receptors. PMID:29669164
Can H2 -receptor upregulation and raised histamine explain an anaphylactoid reaction on cessation of ranitidine in a 19-year-old female? A case report. PMID:29667234
Model-based dosing with concentration feedback as an integral part of personalized hydroxycarbamide management. PMID:29667224
PDE5 inhibitors - pharmacology and clinical applications 20 years after sildenafil discovery. PMID:29667180
Optimization of a drug transporter probe cocktail: potential screening tool for transporter-mediated drug-drug interactions. PMID:29665130
Patterns of antidepressant use during pregnancy: a nationwide population-based cohort study. PMID:29665098
Discovery, characterization and clinical utility of prostaglandin agonists for the treatment of glaucoma. PMID:29665040
Recurrent coronary disease in HIV-infected patients: role of drug-drug interactions. PMID:29663482
Insights into the effects of the endocannabinoid system in cancer: a review. PMID:29663308
Pharmacological treatments for alleviating agitation in dementia: a systematic review and network meta-analysis. PMID:29637593
Population pharmacokinetics of tacrolimus in children with nephrotic syndrome. PMID:29637588
Cannabidiol regulates behavioural alterations and gene expression changes induced by spontaneous cannabinoid withdrawal. PMID:29624642
Higher chlorzoxazone clearance in obese children compared with nonobese peers. PMID:29618168
Reducing potentially inappropriate drug prescribing in nursing home residents: effectiveness of a geriatric intervention. PMID:29607568
Population pharmacokinetics of voriconazole and CYP2C19 polymorphisms for optimizing dosing regimens in renal transplant recipients. PMID:29607533
Vancomycin-induced acute kidney injury in elderly Chinese patients: a single-centre cross-sectional study. PMID:29607531
Selective late sodium current inhibitor GS-458967 suppresses Torsades de Pointes by mostly affecting perpetuation but not initiation of the arrhythmia. PMID:29582428
Analysis of the distribution of spinal NOP receptors in a chronic pain model using NOP-eGFP knock-in mice. PMID:29582417
Body fat reduction without cardiovascular changes in mice after oral treatment with the MAO inhibitor phenelzine. PMID:29582416
The novel μ-opioid receptor agonist PZM21 depresses respiration and induces tolerance to antinociception. PMID:29582414
Late sodium current inhibitors to treat exercise-induced obstruction in hypertrophic cardiomyopathy: an in vitro study in human myocardium. PMID:29579779
Late therapeutic intervention with a respiratory syncytial virus L-protein polymerase inhibitor, PC786, on respiratory syncytial virus infection in human airway epithelium. PMID:29579332
Identification of potent and selective small molecule inhibitors of the cation channel TRPM4. PMID:29579323
Co-expression of μ and δ opioid receptors by mouse colonic nociceptors. PMID:29579315
Enterochromaffin 5-HT cells - A major target for GLP-1 and gut microbial metabolites. PMID:29576437
The relationship between frailty and polypharmacy in older people: A systematic review. PMID:29575094
An update on the clinical evidence that supports biosimilar approvals in Europe. PMID:29575017
First-in-man-proof of concept study with molidustat: a novel selective oral HIF-prolyl hydroxylase inhibitor for the treatment of renal anaemia. PMID:29575006
A pharmacological rationale for improved everolimus dosing in oncology and transplant patients. PMID:29574974
Cannabidiol exerts antiepileptic effects by restoring hippocampal interneuron functions in a temporal lobe epilepsy model. PMID:29574880
Inhibition of human prostate smooth muscle contraction by the LIM kinase inhibitors, SR7826 and LIMKi3. PMID:29574791
Oxycodone-induced tolerance to respiratory depression: reversal by ethanol, pregabalin and protein kinase C inhibition. PMID:29574756
Joint problems arising from lack of repair mechanisms: can cannabinoids help? PMID:29574720
P2Y12 receptor modulation of ADP-evoked intracellular Ca2+ signalling in THP-1 human monocytic cells. PMID:29574692
Targeting glial cannabinoid CB2 receptors to delay the progression of the pathological phenotype in TDP-43 (A315T) transgenic mice, a model of amyotrophic lateral sclerosis. PMID:29574689
Human hepatocytes and cytochrome P450-selective inhibitors predict variability in human drug exposure more accurately than human recombinant P450s. PMID:29574682
The non-biphenyl-tetrazole angiotensin AT1 receptor antagonist eprosartan is a unique and robust inverse agonist of the active state of the AT1 receptor. PMID:29570771
Boosting phagocytosis and anti-inflammatory phenotype in microglia mediates neuroprotection by PPARγ agonist MDG548 in Parkinson's disease models. PMID:29570770
Resolvin D1 attenuates liver ischaemia/reperfusion injury through modulating thioredoxin 2-mediated mitochondrial quality control. PMID:29569721
'Massive' metformin overdose. PMID:29534338
Heat shock protein-27 and sex-selective regulation of muscarinic and proteinase-activated receptor 2-mediated vasodilatation: differential sensitivity to endothelial NOS inhibition. PMID:29532457
In vitro and in vivo characterization of the bifunctional μ and δ opioid receptor ligand UFP-505. PMID:29524334
The effects of the selective muscarinic M3 receptor antagonist darifenacin, and of hyoscine (scopolamine), on motion sickness, skin conductance & cognitive function. PMID:29522648
Impact of serotonin reuptake inhibitor use on breast milk supply in mothers of preterm infants: a retrospective cohort study. PMID:29522259
Cerebellar α6 -subunit-containing GABAA receptors: a novel therapeutic target for disrupted prepulse inhibition in neuropsychiatric disorders. PMID:29518821
Eicosanoids in platelets and the effect of their modulation by aspirin in the cardiovascular system (and beyond). PMID:29512148
Circadian modulation of neuroplasticity by melatonin: a target in the treatment of depression. PMID:29512136
The extracellular matrix as a key regulator of intracellular signalling networks. PMID:29510460
Human secreted proteins SLURP-1 and SLURP-2 control the growth of epithelial cancer cells via interactions with nicotinic acetylcholine receptors. PMID:29505672
Relevance of CYP3A4*20, UGT1A1*37 and UGT1A1*28 variants in irinotecan-induced severe toxicity. PMID:29504153
Treatment with IL-19 improves locomotor functional recovery after contusion trauma to the spinal cord. PMID:29500933
Mapping ligand binding pockets in chloride ClC-1 channels through an integrated in silico and experimental approach using anthracene-9-carboxylic acid and niflumic acid. PMID:29500929
Exchange factor directly activated by cAMP-PKCε signalling mediates chronic morphine-induced expression of purine P2X3 receptor in rat dorsal root ganglia. PMID:29500928
Activity of novel lipid glycine transporter inhibitors on synaptic signalling in the dorsal horn of the spinal cord. PMID:29500820
A method for the quantification of biased signalling at constitutively active receptors. PMID:29498414
Novel long-acting antagonists of muscarinic ACh receptors. PMID:29498041
Yoda1 analogue (Dooku1) which antagonizes Yoda1-evoked activation of Piezo1 and aortic relaxation. PMID:29498036
Pharmacokinetics and pharmacodynamics of dexmedetomidine-induced vasoconstriction in healthy volunteers. PMID:29495085
Use of attention-deficit/hyperactivity disorder medication among older adults in Denmark. PMID:29493809
Evaluation of the effect of rifampin on the pharmacokinetics of the Smoothened inhibitor glasdegib in healthy volunteers. PMID:29488303
Benzodiazepine and Z-drug prescribing in Ireland: analysis of national prescribing trends from 2005 to 2015. PMID:29488252
Ebselen has lithium-like effects on central 5-HT2A receptor function. PMID:29488218
Monoclonal antibodies against metzincin targets. PMID:29488211
Decorin-mediated oncosuppression - a potential future adjuvant therapy for human epithelial cancers. PMID:29488209
The N-terminal domain of a tick evasin is critical for chemokine binding and neutralization and confers specific binding activity to other evasins. PMID:29487134
Antinociceptive effects of novel histamine H3 and H4 receptor antagonists and their influence on morphine analgesia of neuropathic pain in the mouse. PMID:29486058
Niclosamide inhibits vascular smooth muscle cell proliferation and migration and attenuates neointimal hyperplasia in injured rat carotid arteries. PMID:29486057
Defining the ionic mechanisms of optogenetic control of vascular tone by channelrhodopsin-2. PMID:29486056
A two-state model for the kinetics of competitive radioligand binding. PMID:29486053
Adipokines and inflammation: is it a question of weight? PMID:29486050
Antinociceptive effect of two novel transient receptor potential melastatin 8 antagonists in acute and chronic pain models in rat. PMID:29485712
Eicosanoids in the gastrointestinal tract. PMID:29485681
Severe central sleep apnoea associated with nalmefene: a case report. PMID:29479731
4-Hydroxynonenal-induced GPR109A (HCA2 receptor) activation elicits bipolar responses, Gαi -mediated anti-inflammatory effects and Gβγ -mediated cell death. PMID:29473951
Serine proteinases in the turnover of the cartilage extracellular matrix in the joint: implications for therapeutics. PMID:29473950
Facilitation of ischaemia-induced ventricular fibrillation by catecholamines is mediated by β1 and β2 agonism in the rat heart in vitro. PMID:29473948
Non-endocannabinoid N-acylethanolamines and 2-monoacylglycerols in the intestine. PMID:29473944
Physiologically-based pharmacokinetic modelling of a CYP2C19 substrate, BMS-823778, utilizing pharmacogenetic data. PMID:29469197
Clinical safety, tolerability, pharmacokinetics and effects on urinary electrolyte excretion of AZD9977, a novel, selective mineralocorticoid receptor modulator. PMID:29468715
Comparative cardiovascular safety of nonsteroidal anti-inflammatory drugs in patients with hypertension: a population-based cohort study. PMID:29468706
Eicosanoids, prostacyclin and cyclooxygenase in the cardiovascular system. PMID:29468666
GPCRs in pulmonary arterial hypertension: tipping the balance. PMID:29468655
The role of bradykinin receptor type 2 in spontaneous extravasation in mice skin: implications for non-allergic angio-oedema. PMID:29465763
Was 4β-hydroxycholesterol ever going to be a useful marker of CYP3A4 activity? PMID:29464732
Population pharmacokinetics and pharmacogenomics of apixaban in Japanese adult patients with atrial fibrillation. PMID:29457840
Species-specific susceptibility to cannabis-induced convulsions. PMID:29457829
Dihydrodiosgenin protects against experimental acute pancreatitis and associated lung injury through mitochondrial protection and PI3Kγ/Akt inhibition. PMID:29457828
Cannabinoids in arterial, pulmonary and portal hypertension - mechanisms of action and potential therapeutic significance. PMID:29455452
Impact of postdiagnostic statin use on ovarian cancer mortality: A systematic review and meta-analysis of observational studies. PMID:29453799
Caveat Usor: Assessing Differences between Major Chemistry Databases. PMID:29451740
Mechanisms of imidazoline I2 receptor agonist-induced antinociception in rats: involvement of monoaminergic neurotransmission. PMID:29451703
GPCRs in context: sexual dimorphism in the cardiovascular system. PMID:29451687
Intracellular pharmacokinetics of gemcitabine, its deaminated metabolite 2',2'-difluorodeoxyuridine and their nucleotides. PMID:29451684
Alterations in melatonin and 5-HT signalling in the colonic mucosa of mice with dextran-sodium sulfate-induced colitis. PMID:29447434
Aucubin protects against pressure overload-induced cardiac remodelling via the β3 -adrenoceptor-neuronal NOS cascades. PMID:29447430
1,3,6,7-Tetrahydroxy-8-prenylxanthone ameliorates inflammatory responses resulting from the paracrine interaction of adipocytes and macrophages. PMID:29446826
Adverse events linked with the use of chimeric and humanized anti-CD20 antibodies in children with idiopathic nephrotic syndrome. PMID:29436729
Development of a nomogram for the estimation of long-term adherence to clozapine therapy using neutrophil fluorescence. PMID:29427293
Acenocoumarol as an alternative anticoagulant in a patient with warfarin-related nephropathy. PMID:29424022
Population pharmacokinetics of enoxaparin in early stage of paediatric liver transplantation. PMID:29423936
Discontinuities and disruptions in drug dosage guidelines for the paediatric population. PMID:29411410
Corticotropin-releasing factor receptor 2-deficiency eliminates social behaviour deficits and vulnerability induced by cocaine. PMID:29406581
Dual oxidase: a novel therapeutic target in allergic disease. PMID:29405261
Functional interplay between liver X receptor and AMP-activated protein kinase α inhibits atherosclerosis in apolipoprotein E-deficient mice - a new anti-atherogenic strategy. PMID:29394501
Anti-inflammatory therapies in myocardial infarction: failures, hopes and challenges. PMID:29394499
The current state of GPCR-based drug discovery to treat metabolic disease. PMID:29394497
The pharmacodynamic and clinical trial evidence for statin dose. PMID:29393975
Argon attenuates multiorgan failure following experimental aortic cross-clamping. PMID:29388238
Glutathione-PEGylated liposomal methylprednisolone in comparison to free methylprednisolone: slow release characteristics and prolonged lymphocyte depression in a first-in-human study. PMID:29385232
A clinically relevant decrease in abiraterone exposure associated with carbamazepine use in a patient with castration-resistant metastatic prostate cancer. PMID:29384591
The effect of itraconazole and rifampicin on the pharmacokinetics of osimertinib. PMID:29381826
Balancing early access with uncertainties in evidence for drugs authorized by prospective case series - systematic review of reimbursement decisions. PMID:29381234
Time-to-event modelling of effect of codrituzumab on overall survival in patients with hepatocellular carcinoma. PMID:29381229
Exposure-response characterization of tofacitinib efficacy in moderate to severe ulcerative colitis: Results from a dose-ranging phase 2 trial. PMID:29377257
Developmental pharmacogenetics of CYP2C19 in neonates and young infants: omeprazole as a probe drug. PMID:29377228
Acute ethanol exposure has bidirectional actions on the endogenous neuromodulator adenosine in rat hippocampus. PMID:29361192
Resolvin E1, resolvin D1 and resolvin D2 inhibit constriction of rat thoracic aorta and human pulmonary artery induced by the thromboxane mimetic U46619. PMID:29352769
Cambogin suppresses dextran sulphate sodium-induced colitis by enhancing Treg cell stability and function. PMID:29352742
In vivo effects of μ-opioid receptor agonist/δ-opioid receptor antagonist peptidomimetics following acute and repeated administration. PMID:29352503
Influence of pharmacogenetic polymorphisms and demographic variables on metformin pharmacokinetics in an admixed Brazilian cohort. PMID:29352482
First-in-human study to assess the safety, pharmacokinetics and pharmacodynamics of BMS-962212, a direct, reversible, small molecule factor XIa inhibitor in non-Japanese and Japanese healthy subjects. PMID:29346838
Clinical impact of pharmacokinetic interactions between the HCV protease inhibitor simeprevir and frequently used concomitant medications. PMID:29345798
Pharmacokinetic/pharmacodynamic drug-drug interactions of avatrombopag when coadministered with dual or selective CYP2C9 and CYP3A interacting drugs. PMID:29341245
The impact of diuretic use and ABCG2 genotype on the predictive performance of a published allopurinol dosing tool. PMID:29341237
Better characterization of vinflunine pharmacokinetics variability and exposure/toxicity relationship to improve its use: Analyses from 18 trials. PMID:29341179
Gabapentin prevents synaptogenesis between sensory and spinal cord neurons induced by thrombospondin-4 acting on pre-synaptic Cav α2 δ1 subunits and involving T-type Ca2+ channels. PMID:29338087
Liver kinase B1/AMP-activated protein kinase-mediated regulation by gentiopicroside ameliorates P2X7 receptor-dependent alcoholic hepatosteatosis. PMID:29338075
The use of chemogenetics in behavioural neuroscience: receptor variants, targeting approaches and caveats. PMID:29338070
Single and combined effects of plant-derived and synthetic cannabinoids on cognition and cannabinoid-associated withdrawal signs in mice. PMID:29338068
Rhabdomyolysis after co-administration of a statin and fusidic acid: an analysis of the literature and of the WHO database of adverse drug reactions. PMID:29337401
Rapidly developing heart failure from capecitabine cardiotoxicity: a case study. PMID:29336052
Dasatinib-induced pulmonary arterial hypertension. PMID:29334406
Metabolic acidosis and anaemia associated with dorzolamide in a patient with impaired renal function. PMID:29333622
Adiponectin inhibits inflammatory cytokines production by Beclin-1 phosphorylation and B-cell lymphoma 2 mRNA destabilization: role for autophagy induction. PMID:29333604
Sustained plasma hepcidin suppression and iron elevation by Anticalin-derived hepcidin antagonist in cynomolgus monkey. PMID:29329501
Substance P as a putative efferent transmitter mediates GABAergic inhibition in mouse taste buds. PMID:29328505
Reversal of mecamylamine-induced effects in healthy subjects by nicotine receptor agonists: Cognitive and (electro) physiological responses. PMID:29319910
Pharmacokinetic-pharmacodynamic modelling of neutrophil response to G-CSF in healthy subjects and patients with chemotherapy-induced neutropenia. PMID:29318653
Effect of the angiotensin receptor-neprilysin inhibitor sacubitril/valsartan on the pharmacokinetics and pharmacodynamics of a single dose of furosemide. PMID:29318651
Partial rescue of F508del-cystic fibrosis transmembrane conductance regulator channel gating with modest improvement of protein processing, but not stability, by a dual-acting small molecule. PMID:29318594
Prophylactic benefits of systemically delivered simvastatin treatment in a house dust mite challenged murine model of allergic asthma. PMID:29318574
The 2018 Nucleic Acids Research database issue and the online molecular biology database collection. PMID:29316735
Topical administration of regorafenib eye drops: phase I dose-escalation study in healthy volunteers. PMID:29315699
The natural compound, formononetin, extracted from Astragalus membranaceus increases adipocyte thermogenesis by modulating PPARγ activity. PMID:29315511
Fixed dosing of intravenous tocilizumab in rheumatoid arthritis. Results from a population pharmacokinetic analysis. PMID:29314183
Interferon γ treatment increases endocannabinoid and related N-acylethanolamine levels in T84 human colon carcinoma cells. PMID:29313885
Expression, distribution and function of kinin B1 receptor in the rat diabetic retina. PMID:29285756
The soluble guanylate cyclase stimulator IW-1973 prevents inflammation and fibrosis in experimental non-alcoholic steatohepatitis. PMID:29281143
Simvastatin activates single skeletal RyR1 channels but exerts more complex regulation of the cardiac RyR2 isoform. PMID:29278865
Tanshinones that selectively block the collagenase activity of cathepsin K provide a novel class of ectosteric antiresorptive agents for bone. PMID:29278432
Role of signalling molecules in behaviours mediated by the δ opioid receptor agonist SNC80. PMID:29278419
Proton-independent activation of acid-sensing ion channel 3 by an alkaloid, lindoldhamine, from Laurus nobilis. PMID:29277899
Different contributions of chemokine N-terminal features attest to a different ligand binding mode and a bias towards activation of ACKR3/CXCR7 compared with CXCR4 and CXCR3. PMID:29272550
No pain, no gain: balancing central versus peripheral benefits of analgesics in the age of the opioid crisis. PMID:29243218
Bumetanide blocks the acquisition of conditioned fear in adult rats. PMID:29235092
Cyclic analogues of α-conotoxin Vc1.1 inhibit colonic nociceptors and provide analgesia in a mouse model of chronic abdominal pain. PMID:29194563
GPCRdb in 2018: adding GPCR structure models and ligands. PMID:29155946
Sophocarpine attenuates wear particle-induced implant loosening by inhibiting osteoclastogenesis and bone resorption via suppression of the NF-κB signalling pathway in a rat model. PMID:29130485
The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands PubMed citations: 924.

924 articles citing: The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands

What We Have Learned from Animal Models to Understand the Etiology and Pathology of Endometrioma-Related Infertility. PMID:35884788
Cytosolic β-glucosidase inhibition and renal blood flow suppression are leading causes for the enhanced systemic exposure of salidroside in hypoxic rats. PMID:35539855
Systematic illumination of druggable genes in cancer genomes. PMID:35196490
Structure-Based Design of a Chemical Probe Set for the 5-HT5A Serotonin Receptor. PMID:35195401
Intrinsically disordered proteins play diverse roles in cell signaling. PMID:35177069
Sequence-based prediction of protein binding regions and drug-target interactions. PMID:35135622
Interactions of a boron-containing levodopa derivative on D2 dopamine receptor and its effects in a Parkinson disease model. PMID:34806120
Strategies to identify candidate repurposable drugs: COVID-19 treatment as a case example. PMID:34785660
New Antagonists of the Membrane Androgen Receptor OXER1 from the ZINC Natural Product Database. PMID:34778638
The IUPHAR/BPS guide to PHARMACOLOGY in 2022: curating pharmacology for COVID-19, malaria and antibacterials. PMID:34718737
Current Developments in Native Nanometric Discoidal Membrane Bilayer Formed by Amphipathic Polymers. PMID:34361157
MUSTARD-a comprehensive resource of mutation-specific therapies in cancer. PMID:34309639
Motions around conserved helical weak spots facilitate GPCR activation. PMID:34272892
In vivo and in vitro human gene essentiality estimations capture contrasting functional constraints. PMID:34268495
Physiologically based pharmacokinetic modelling of treprostinil after intravenous injection and extended-release oral tablet administration in healthy volunteers: An extrapolation to other patient populations including patients with hepatic impairment. PMID:34190364
Deep Learning in Virtual Screening: Recent Applications and Developments. PMID:33922714
Trends in application of advancing computational approaches in GPCR ligand discovery. PMID:33641446
Endothelial-protective effects of a G-protein-biased sphingosine-1 phosphate receptor-1 agonist, SAR247799, in type-2 diabetes rats and a randomized placebo-controlled patient trial. PMID:33125753
Non-Mendelian inheritance during inbreeding of Cav3.2 and Cav2.3 deficient mice. PMID:33009476
Structure of a Hallucinogen-Activated Gq-Coupled 5-HT2A Serotonin Receptor. PMID:32946782
Advances in Understanding the Initial Steps of Pruritoceptive Itch: How the Itch Hits the Switch. PMID:32664385
Machine learning and AI-based approaches for bioactive ligand discovery and GPCR-ligand recognition. PMID:32645448
Agonist bias and agonist-dependent antagonism at corticotrophin releasing factor receptors. PMID:32529807
Self-restoration of cardiac excitation rhythm by anti-arrhythmic ion channel gating. PMID:32510321
Why data citation isn't working, and what to do about it. PMID:32367113
Nintedanib Inhibits Wnt3a-Induced Myofibroblast Activation by Suppressing the Src/β-Catenin Pathway. PMID:32231574
Network Pharmacology Identifies the Mechanisms of Action of TaohongSiwu Decoction Against Essential Hypertension. PMID:32187175
Wikidata as a knowledge graph for the life sciences. PMID:32180547
Direct inhibition of the TLR4/MyD88 pathway by geniposide suppresses HIF-1α-independent VEGF expression and angiogenesis in hepatocellular carcinoma. PMID:32144747
Disease pharmacokinetic-pharmacodynamic modelling in acute intermittent porphyria to support the development of mRNA-based therapies. PMID:32133631
Discovery of Multitarget-Directed Ligands Against Influenza A Virus From Compound Yizhihao Through a Predictive System for Compound-Protein Interactions. PMID:32117796
Virtual discovery of melatonin receptor ligands to modulate circadian rhythms. PMID:32040955
The IUPHAR Guide to Immunopharmacology: connecting immunology and pharmacology. PMID:32020584
The peripheral CB1 receptor antagonist JD5037 attenuates liver fibrosis via a CB1 receptor/β-arrestin1/Akt pathway. PMID:32017042
Protein kinase A facilitates relaxation of mouse ileum via phosphorylation of neuronal nitric oxide synthase. PMID:31975425
Machine learning approaches and databases for prediction of drug-target interaction: a survey paper. PMID:31950972
CMTTdb: the cancer molecular targeted therapy database. PMID:31930068
Phenomenological models of NaV1.5. A side by side, procedural, hands-on comparison between Hodgkin-Huxley and kinetic formalisms. PMID:31767896
The IUPHAR/BPS Guide to PHARMACOLOGY in 2020: extending immunopharmacology content and introducing the IUPHAR/MMV Guide to MALARIA PHARMACOLOGY. PMID:31691834
Therapeutic target database 2020: enriched resource for facilitating research and early development of targeted therapeutics. PMID:31691823
The Signaling Pathways Project, an integrated 'omics knowledgebase for mammalian cellular signaling pathways. PMID:31672983
Closing the Gap Between Therapeutic Use and Mode of Action in Remedial Herbs. PMID:31632273
Antifibrotic Mechanism of Cinobufagin in Bleomycin-Induced Pulmonary Fibrosis in Mice. PMID:31572194
A Kinetic Map of the Homomeric Voltage-Gated Potassium Channel (Kv) Family. PMID:31481875
Multi-functionality of proteins involved in GPCR and G protein signaling: making sense of structure-function continuum with intrinsic disorder-based proteoforms. PMID:31428838
Rare, functional, somatic variants in gene families linked to cancer genes: GPCR signaling as a paradigm. PMID:31337866
Exploring the dark genome: implications for precision medicine. PMID:31270560
DeepConv-DTI: Prediction of drug-target interactions via deep learning with convolution on protein sequences. PMID:31199797
Leucine-rich repeat kinase 2 (LRRK2) inhibitors differentially modulate glutamate release and Serine935 LRRK2 phosphorylation in striatal and cerebrocortical synaptosomes. PMID:31149340
Bouchardatine analogue alleviates non-alcoholic hepatic fatty liver disease/non-alcoholic steatohepatitis in high-fat fed mice by inhibiting ATP synthase activity. PMID:31113010
Dipeptidyl peptidase-4 inhibitors lower the risk of autoimmune disease in patients with type 2 diabetes mellitus: A nationwide population-based cohort study. PMID:30964554
Repertoires of G protein-coupled receptors for Ciona-specific neuropeptides. PMID:30936317
Bipolar Cell Type-Specific Expression and Conductance of Alpha-7 Nicotinic Acetylcholine Receptors in the Mouse Retina. PMID:30934054
Acute interaction between oral glucose (75 g as Lucozade) and inorganic nitrate: Decreased insulin clearance, but lack of blood pressure-lowering. PMID:30845346
Geometric characterisation of disease modules. PMID:30839777
Assessing the public landscape of clinical-stage pharmaceuticals through freely available online databases. PMID:30690196
A novel nitroalkene-α-tocopherol analogue inhibits inflammation and ameliorates atherosclerosis in Apo E knockout mice. PMID:30588602
New steps in infliximab therapeutic drug monitoring in patients with inflammatory bowel diseases. PMID:30575085
Challenges and advances in atomistic simulations of potassium and sodium ion channel gating and permeation. PMID:30471114
Analysis of Single-Cell RNA-Seq Identifies Cell-Cell Communication Associated with Tumor Characteristics. PMID:30404002
Uncovering new disease indications for G-protein coupled receptors and their endogenous ligands. PMID:30285606
Challenges of Connecting Chemistry to Pharmacology: Perspectives from Curating the IUPHAR/BPS Guide to PHARMACOLOGY. PMID:30087946
Compound Ranking Based on Fuzzy Three-Dimensional Similarity Improves the Performance of Docking into Homology Models of G-Protein-Coupled Receptors. PMID:30023670
Exploring the functional impact of alternative splicing on human protein isoforms using available annotation sources. PMID:29931155
Tissue-Specific Analysis of Pharmacological Pathways. PMID:29920991
Lack of current observed in HEK293 cells expressing NALCN channels. PMID:29892559
Deglycosylation of Shaker KV channels affects voltage sensing and the open-closed transition. PMID:29880580
Dipeptidyl peptidase-4 inhibitor use is associated with decreased risk of fracture in patients with type 2 diabetes: a population-based cohort study. PMID:29766544
Transcriptional Profiling of Somatostatin Interneurons in the Spinal Dorsal Horn. PMID:29717160
Experimental and In Silico Analysis of Cordycepin and its Derivatives as Endometrial Cancer Treatment. PMID:29673423
PKIDB: A Curated, Annotated and Updated Database of Protein Kinase Inhibitors in Clinical Trials. PMID:29662024
NKX2-5 regulates human cardiomyogenesis via a HEY2 dependent transcriptional network. PMID:29636455
The latent geometry of the human protein interaction network. PMID:29635317
Unexplored therapeutic opportunities in the human genome. PMID:29472638
Structure of the D2 dopamine receptor bound to the atypical antipsychotic drug risperidone. PMID:29466326
In vitro and in vivo effects of MK2206 and chloroquine combination therapy on endometriosis: autophagy may be required for regrowth of endometriosis. PMID:29457968
Nutraceuticals: opening the debate for a regulatory framework. PMID:29433155
Decoys Selection in Benchmarking Datasets: Overview and Perspectives. PMID:29416509
Neurotransmitter deficits from frontotemporal lobar degeneration. PMID:29373632
A live cell assay of GPCR coupling allows identification of optogenetic tools for controlling Go and Gi signaling. PMID:29338718
Teicoplanin anaphylaxis associated with surgical prophylaxis. PMID:29319891
New perspectives on the role of melatonin in human sleep, circadian rhythms and their regulation. PMID:29318587
Domain retention in transcription factor fusion genes and its biological and clinical implications: a pan-cancer study. PMID:29299133
G Protein-Coupled Receptors as Targets for Approved Drugs: How Many Targets and How Many Drugs? PMID:29298813
Gender differences in clinical registration trials: is there a real problem? PMID:29293280
Association between antidepressant medication use and epithelial ovarian cancer risk: a systematic review and meta-analysis of observational studies. PMID:29292523
Population exposure-safety analysis of cediranib for Phase I and II studies in patients with cancer. PMID:29274100
Characterization of adherence and persistence profile in a real-life population of patients treated with adalimumab. PMID:29272556
Aprepitant and fosaprepitant decrease the effectiveness of hormonal contraceptives. PMID:29266364
Wheel running during chronic nicotine exposure is protective against mecamylamine-precipitated withdrawal and up-regulates hippocampal α7 nACh receptors in mice. PMID:29266170
Pharmacogenomics of GPCR Drug Targets. PMID:29249361
Identification of an (-)-englerin A analogue, which antagonizes (-)-englerin A at TRPC1/4/5 channels. PMID:29247460
Evaluation of the effect of dabrafenib and metabolites on QTc interval in patients with BRAF V600-mutant tumours. PMID:29243287
Shikonin inhibits myeloid differentiation protein 2 to prevent LPS-induced acute lung injury. PMID:29243243
Finding the needle in the haystack: systematic identification of psychobiotics. PMID:29243233
Mirabegron: potential off target effects and uses beyond the bladder. PMID:29243229
Embryonic exposure to valproic acid affects the histaminergic system and the social behaviour of adult zebrafish (Danio rerio). PMID:29235100
Effects of corilagin on alleviating cholestasis via farnesoid X receptor-associated pathways in vitro and in vivo. PMID:29235094
Anti-Parkinsonian and anti-dyskinetic profiles of two novel potent and selective nociceptin/orphanin FQ receptor agonists. PMID:29232769
Involvement of CYP1B1 in interferon γ-induced alterations of epithelial barrier integrity. PMID:29232759
Low molecular weight heparin for the prevention of severe preeclampsia: where next? PMID:29226532
RampDB: a web application and database for the exploration and prediction of receptor activity modifying protein interactions. PMID:29220456
Knockdown of the transcript of ERK in the brain modulates hypothalamic neuropeptide-mediated appetite control in amphetamine-treated rats. PMID:29215157
Pharmacology in translation: the preclinical and early clinical profile of the novel α2/3 functionally selective GABAA receptor positive allosteric modulator PF-06372865. PMID:29214652
Opioid-induced inhibition of the human 5-HT and noradrenaline transporters in vitro: link to clinical reports of serotonin syndrome. PMID:29210063
Induction of mast cell accumulation by chymase via an enzymatic activity- and intercellular adhesion molecule-1-dependent mechanism. PMID:29197072
Characterization of the properties of a selective, orally bioavailable autotaxin inhibitor in preclinical models of advanced stages of liver fibrosis. PMID:29197066
Oxaliplatin-induced enteric neuronal loss and intestinal dysfunction is prevented by co-treatment with BGP-15. PMID:29194564
Is tranexamic acid exposure related to blood loss in hip arthroplasty? A pharmacokinetic-pharmacodynamic study. PMID:29193211
Can non-clinical repolarization assays predict the results of clinical thorough QT studies? Results from a research consortium. PMID:29181850
Achyranthes bidentata polypeptide protects dopaminergic neurons from apoptosis in Parkinson's disease models both in vitro and in vivo. PMID:29181847
Demonstration of an anti-hyperalgesic effect of a novel pan-Trk inhibitor PF-06273340 in a battery of human evoked pain models. PMID:29178434
Evaluation of modafinil as a perpetrator of metabolic drug-drug interactions using a model informed cocktail reaction phenotyping trial protocol. PMID:29178272
Effects of the antagomiRs 15b and 200b on the altered healing pattern of diabetic mice. PMID:29178246
Differential involvement of ipsilateral and contralateral spinal cord astrocyte D-serine in carrageenan-induced mirror-image pain: role of σ1 receptors and astrocyte gap junctions. PMID:29172248
Xenopus-derived glucagon-like peptide-1 and polyethylene-glycosylated glucagon-like peptide-1 receptor agonists: long-acting hypoglycaemic and insulinotropic activities with potential therapeutic utilities. PMID:29171021
Neurocognition and subjective experience following acute doses of the synthetic cannabinoid JWH-018: a phase 1, placebo-controlled, pilot study. PMID:29164599
Tetramethylpyrazine nitrone activates the BDNF/Akt/CREB pathway to promote post-ischaemic neuroregeneration and recovery of neurological functions in rats. PMID:29161771
Mechanism of doxorubicin cardiotoxicity evaluated by integrating multiple molecular effects into a biophysical model. PMID:29161764
Quantifying the relationship between inhibition of VEGF receptor 2, drug-induced blood pressure elevation and hypertension. PMID:29161763
Simultaneous use of erythropoietin and LFM-A13 as a new therapeutic approach for colorectal cancer. PMID:29160911
4-Aminopyridine: a pan voltage-gated potassium channel inhibitor that enhances Kv 7.4 currents and inhibits noradrenaline-mediated contraction of rat mesenteric small arteries. PMID:29156097
Multiple role of 3-mercaptopyruvate sulfurtransferase: antioxidative function, H2 S and polysulfide production and possible SOx production. PMID:29156095
DGIdb 3.0: a redesign and expansion of the drug-gene interaction database. PMID:29156001
GI-530159, a novel, selective, mechanosensitive two-pore-domain potassium (K2P ) channel opener, reduces rat dorsal root ganglion neuron excitability. PMID:29150838
The IUPHAR/BPS Guide to PHARMACOLOGY in 2018: updates and expansion to encompass the new guide to IMMUNOPHARMACOLOGY. PMID:29149325
Use of oral anticoagulants in German nursing home residents: drug use patterns and predictors for treatment choice. PMID:29148592
Drug-related deaths in hospital inpatients: A retrospective cohort study. PMID:29148077
Role of p62/SQSTM1 beyond autophagy: a lesson learned from drug-induced toxicity in vitro. PMID:29148034
Therapeutic target database update 2018: enriched resource for facilitating bench-to-clinic research of targeted therapeutics. PMID:29140520
The novel, potent and highly selective 5-HT4 receptor agonist YH12852 significantly improves both upper and lower gastrointestinal motility. PMID:29139561
Tauroursodeoxycholic acid inhibits intestinal inflammation and barrier disruption in mice with non-alcoholic fatty liver disease. PMID:29139555
Up-regulation of PYK2/PKCα-dependent haem oxygenase-1 by CO-releasing molecule-2 attenuates TNF-α-induced lung inflammation. PMID:29139546
Inhibition of acid-sensing ion channels by diminazene and APETx2 evoke partial and highly variable antihyperalgesia in a rat model of inflammatory pain. PMID:29134638
RTP801 is a critical factor in the neurodegeneration process of A53T α-synuclein in a mouse model of Parkinson's disease under chronic restraint stress. PMID:29130486
PRN473, an inhibitor of Bruton's tyrosine kinase, inhibits neutrophil recruitment via inhibition of macrophage antigen-1 signalling. PMID:29130484
Calcimimetic and calcilytic therapies for inherited disorders of the calcium-sensing receptor signalling pathway. PMID:29127708
Towards functional selectivity for α6β3γ2 GABAA receptors: a series of novel pyrazoloquinolinones. PMID:29127702
Usefulness of knockout mice to clarify the role of the opioid system in chronic pain. PMID:29124744
Drug target ontology to classify and integrate drug discovery data. PMID:29122012
Microbial biotransformations in the human distal gut. PMID:29116650
NPASS: natural product activity and species source database for natural product research, discovery and tool development. PMID:29106619
Dicloxacillin induces CYP2C19, CYP2C9 and CYP3A4 in vivo and in vitro. PMID:29105855
Protease-activated receptor 1 inhibition protects mice against thrombin-dependent respiratory syncytial virus and human metapneumovirus infections. PMID:29105740
Immune-pineal axis - acute inflammatory responses coordinate melatonin synthesis by pinealocytes and phagocytes. PMID:29105727
Response to in vitro and physiologically-based pharmacokinetic assessment of the drug-drug interaction potential of canagliflozin. PMID:29098700
Results and evaluation of a first-in-human study of RG7342, an mGlu5 positive allosteric modulator, utilizing Bayesian adaptive methods. PMID:29096426
The Chemistry Development Kit (CDK) v2.0: atom typing, depiction, molecular formulas, and substructure searching. PMID:29086040
Targeting inflammation to reduce cardiovascular disease risk. PMID:29080212
Population pharmacokinetics of exendin-(9-39) and clinical dose selection in patients with congenital hyperinsulinism. PMID:29077992
Risk factors contributing to a low darunavir plasma concentration. PMID:29077230
Trends in GPCR drug discovery: new agents, targets and indications. PMID:29075003
Comparative risks of diabetes-related complications of basal insulins: a longitudinal population-based cohort of type 1 diabetes 1999-2013 in Taiwan. PMID:29073329
An Alignment-Independent 3D-QSAR Study of FGFR2 Tyrosine Kinase Inhibitors. PMID:29071223
Parenteral bilirubin in healthy volunteers: a reintroduction in translational research. PMID:29068066
GPR35 mediates lodoxamide-induced migration inhibitory response but not CXCL17-induced migration stimulatory response in THP-1 cells; is GPR35 a receptor for CXCL17? PMID:29068046
Berberine attenuates hepatic steatosis and enhances energy expenditure in mice by inducing autophagy and fibroblast growth factor 21. PMID:29065221
Selectivity, cell permeability and oral availability studies of novel bromophenol derivative HPN as protein tyrosine phosphatase 1B inhibitor. PMID:29059712
Update on the pharmacology of calcitonin/CGRP family of peptides: IUPHAR Review 25. PMID:29059473
Comparative safety of systemic and low-bioavailability steroids in inflammatory bowel disease: Systematic review and network meta-analysis. PMID:29057539
QTc prolongation during ciprofloxacin and fluconazole combination therapy: prevalence and associated risk factors. PMID:29057492
Vortioxetine exerts anti-inflammatory and immunomodulatory effects on human monocytes/macrophages. PMID:29057467
Insulin-like growth factor-1 activates PI3K/Akt signalling to protect human retinal pigment epithelial cells from amiodarone-induced oxidative injury. PMID:29057462
Differential effects of selective agonists of neuromedin U1 and U2 receptors in obese and diabetic mice. PMID:29057457
Cannabidiolic acid methyl ester, a stable synthetic analogue of cannabidiolic acid, can produce 5-HT1A receptor-mediated suppression of nausea and anxiety in rats. PMID:29057454
5-HT1F receptor-mediated mitochondrial biogenesis for the treatment of Parkinson's disease. PMID:29057453
Transient receptor potential vanilloid 4 channel regulates vascular endothelial permeability during colonic inflammation in dextran sulphate sodium-induced murine colitis. PMID:29053877
Whole body physiologically based modelling of β-blockers in the rat: events in tissues and plasma following an i.v. bolus dose. PMID:29053169
FL-926-16, a novel bioavailable carnosinase-resistant carnosine derivative, prevents onset and stops progression of diabetic nephropathy in db/db mice. PMID:29053168
Optimal dosing and delivery of parathyroid hormone and its analogues for osteoporosis and hypoparathyroidism - translating the pharmacology. PMID:29049872
A step-down protocol for omalizumab treatment in oral corticosteroid-dependent allergic asthma patients. PMID:29044640
Short- and long-term complications of in utero exposure to lamotrigine. PMID:29044597
Amelioration of autoimmunity with an inhibitor selectively targeting all active centres of the immunoproteasome. PMID:29034459
Ledipasvir and tenofovir drug interaction in human immunodeficiency virus-hepatitis C virus coinfected patients: Impact on tenofovir trough concentrations and renal safety. PMID:29028125
Phenytoin: its potential as neuroprotective and retinoprotective drug. PMID:29027243
Heterogeneous distribution of alectinib in neuroblastoma xenografts revealed by matrix-assisted laser desorption ionization mass spectrometry imaging: a pilot study. PMID:29027209
Rapid vasodilation to raloxifene: role of oestrogen receptors and off-target effects. PMID:28983907
Transient receptor potential vanilloid 1 inhibitors block laparotomy- and opioid-induced infarct size reduction in rats. PMID:28982207
Effects of the kinase inhibitor sorafenib on heart, muscle, liver and plasma metabolism in vivo using non-targeted metabolomics analysis. PMID:28977680
Pituitary adenylate cyclase-activating polypeptide receptors in the trigeminovascular system: implications for migraine. PMID:28977676
Characterization of a rat model of bortezomib-induced painful neuropathy. PMID:28972650
Agonism of free fatty acid receptors 1 and 4 generates peptide YY-mediated inhibitory responses in mouse colon. PMID:28971469
Antidepressant-like effects of BU10119, a novel buprenorphine analogue with mixed κ/μ receptor antagonist properties, in mice. PMID:28967123
Immuno-pharmacological characterization of group II metabotropic glutamate receptors controlling glutamate exocytosis in mouse cortex and spinal cord. PMID:28967122
Epigenetic regulation of melatonin receptors in neuropsychiatric disorders. PMID:28967098
Chronic treatment with novel nanoformulated micelles of rapamycin, Rapatar, protects diabetic heart against ischaemia/reperfusion injury. PMID:28967097
Adulteration of proprietary Chinese medicines and health products with undeclared drugs: experience of a tertiary toxicology laboratory in Hong Kong. PMID:28965348
Development of one paediatric and one neonatal formulary list in hospital settings. PMID:28963995
Dopamine D2 receptor signalling controls inflammation in acute pancreatitis via a PP2A-dependent Akt/NF-κB signalling pathway. PMID:28963856
BIO 300, a nanosuspension of genistein, mitigates pneumonitis/fibrosis following high-dose radiation exposure in the C57L/J murine model. PMID:28963717
The monoacylglycerol lipase inhibitor KML29 with gabapentin synergistically produces analgesia in mice. PMID:28963716
Population pharmacodynamic modelling of midazolam induced sedation in terminally ill adult patients. PMID:28960387
Aldosterone-Sensing Neurons in the NTS Exhibit State-Dependent Pacemaker Activity and Drive Sodium Appetite via Synergy with Angiotensin II Signaling. PMID:28957668
Human podocytes express functional thermosensitive TRPV channels. PMID:28945920
Synthetic peptides designed to modulate adiponectin assembly improve obesity-related metabolic disorders. PMID:28945274
VPAC1 and VPAC2 receptor activation on GABA release from hippocampal nerve terminals involve several different signalling pathways. PMID:28945273
Different protein kinase C isoenzymes mediate inhibition of cardiac rapidly activating delayed rectifier K+ current by different G-protein coupled receptors. PMID:28941256
Nonclinical cardiovascular safety of pitolisant: comparing International Conference on Harmonization S7B and Comprehensive in vitro Pro-arrhythmia Assay initiative studies. PMID:28941245
Assembly and architecture of the Wnt/β-catenin signalosome at the membrane. PMID:28941231
Adverse effects of a single dose of gentamicin in adults: a systematic review. PMID:28940715
Protective, repairing and fibrinolytic effects of rivaroxaban on vascular endothelium. PMID:28940408
G protein-coupled receptors not currently in the spotlight: free fatty acid receptor 2 and GPR35. PMID:28940377
Lon protease: a novel mitochondrial matrix protein in the interconnection between drug-induced mitochondrial dysfunction and endoplasmic reticulum stress. PMID:28940366
BK β1 subunit-dependent facilitation of ethanol inhibition of BK current and cerebral artery constriction is mediated by the β1 transmembrane domain 2. PMID:28940182
Early treatment with Resolvin E1 facilitates myocardial recovery from ischaemia in mice. PMID:28925017
A new negative allosteric modulator, AP14145, for the study of small conductance calcium-activated potassium (KCa 2) channels. PMID:28925012
Targeting nociceptive transient receptor potential channels to treat chronic pain: current state of the field. PMID:28924972
Gα12 facilitates shortening in human airway smooth muscle by modulating phosphoinositide 3-kinase-mediated activation in a RhoA-dependent manner. PMID:28921504
Is systems pharmacology ready to impact upon therapy development? A study on the cholesterol biosynthesis pathway. PMID:28910500
PDE1A inhibition elicits cGMP-dependent relaxation of rat mesenteric arteries. PMID:28910498
p53-mediated regulation of bile acid disposition attenuates cholic acid-induced cholestasis in mice. PMID:28910492
Regulation of Wnt/β-catenin signalling by tankyrase-dependent poly(ADP-ribosyl)ation and scaffolding. PMID:28910490
Nucleoside/nucleotide reverse transcriptase inhibitors attenuate angiogenesis and lymphangiogenesis by impairing receptor tyrosine kinases signalling in endothelial cells. PMID:28910489
Activation of G protein-coupled oestrogen receptor 1 at the onset of reperfusion protects the myocardium against ischemia/reperfusion injury by reducing mitochondrial dysfunction and mitophagy. PMID:28906548
Renal function monitoring in heart failure - what is the optimal frequency? A narrative review. PMID:28901643
Tetrandrine antagonizes acute megakaryoblastic leukaemia growth by forcing autophagy-mediated differentiation. PMID:28901537
Beyond symptomatic effects: potential of donepezil as a neuroprotective agent and disease modifier in Alzheimer's disease. PMID:28901528
Importance of the second extracellular loop for melatonin MT1 receptor function and absence of melatonin binding in GPR50. PMID:28898928
Repurposing a novel parathyroid hormone analogue to treat hypoparathyroidism. PMID:28898923
Molecular Connectivity Predefines Polypharmacology: Aliphatic Rings, Chirality, and sp3 Centers Enhance Target Selectivity. PMID:28894419
External evaluation of population pharmacokinetic models for ciclosporin in adult renal transplant recipients. PMID:28891596
Co-administration of cyclosporine and ticagrelor may lead to a higher exposure to cyclosporine: a case report of a 49-year-old man. PMID:28891590
Global population pharmacokinetics of the investigational Aurora A kinase inhibitor alisertib in cancer patients: rationale for lower dosage in Asia. PMID:28891222
Pharmacokinetics of multiple doses of co-crystal of tramadol-celecoxib: findings from a four-way randomized open-label phase I clinical trial. PMID:28888220
Factor Xa inhibition by rivaroxaban in the trough steady state can significantly reduce thrombin generation. PMID:28888219
Impact of non-adherence on the safety and efficacy of uric acid-lowering therapies in the treatment of gout. PMID:28888218
Magnesium therapy improves outcome in Streptococcus pneumoniae meningitis by altering pneumolysin pore formation. PMID:28888095
Modulation of hERG potassium channels by a novel small molecule activator. PMID:28887817
Selective targeting of M-type potassium Kv 7.4 channels demonstrates their key role in the regulation of dopaminergic neuronal excitability and depression-like behaviour. PMID:28885682
Drug-drug interaction potential in men treated with enzalutamide: Mind the gap. PMID:28881501
Melatonin: does it have utility in the treatment of haematological neoplasms? PMID:28880375
GPCR signalling from within the cell. PMID:28872669
Principles of pharmacology in the eye. PMID:28865239
Dose-dependent acute liver injury with hypersensitivity features in humans due to a novel microsomal prostaglandin E synthase 1 inhibitor. PMID:28865237
Evaluation of the pharmacokinetic drug interaction potential of tivantinib (ARQ 197) using cocktail probes in patients with advanced solid tumours. PMID:28865153
A single Markov-type kinetic model accounting for the macroscopic currents of all human voltage-gated sodium channel isoforms. PMID:28863150
Light-induced regulation of ligand-gated channel activity. PMID:28859250
Widespread brain distribution and activity following i.c.v. infusion of anti-β-secretase (BACE1) in nonhuman primates. PMID:28859225
Use of radiotelemetry to assess perinatal cardiac function in the ovine fetus and newborn. PMID:28855176
Tetrahydrocannabinolic acid is a potent PPARγ agonist with neuroprotective activity. PMID:28853159
Neonicotinoid insecticides differently modulate acetycholine-induced currents on mammalian α7 nicotinic acetylcholine receptors. PMID:28853147
Clinical significance of CYP2C19 polymorphisms on the metabolism and pharmacokinetics of 11β-hydroxysteroid dehydrogenase type-1 inhibitor BMS-823778. PMID:28850715
Opioid and hypocretin neuromodulation of ventral tegmental area neuronal subpopulations. PMID:28849596
Chloroquine is a potent pulmonary vasodilator that attenuates hypoxia-induced pulmonary hypertension. PMID:28849593
α-Spinasterol: a COX inhibitor and a transient receptor potential vanilloid 1 antagonist presents an antinociceptive effect in clinically relevant models of pain in mice. PMID:28849589
Noncholestatic acute hepatocellular injury following candesartan administration. PMID:28841231
Distinct in vivo target occupancy by bivalent- and induced-fit-like binding drugs. PMID:28838028
Hyperhomocysteinaemia and vascular injury: advances in mechanisms and drug targets. PMID:28836260
A comment on 'An assessment of the variation in the concentrations of acetylcysteine in infusions for the treatment of paracetamol overdose'. PMID:28833373
Population pharmacokinetic meta-analysis of ramucirumab in cancer patients. PMID:28833321
Class I histone deacetylase inhibition improves pancreatitis outcome by limiting leukocyte recruitment and acinar-to-ductal metaplasia. PMID:28832971
Differential binding of tetrodotoxin and its derivatives to voltage-sensitive sodium channel subtypes (Nav 1.1 to Nav 1.7). PMID:28832970
Rubiarbonone C inhibits platelet-derived growth factor-induced proliferation and migration of vascular smooth muscle cells through the focal adhesion kinase, MAPK and STAT3 Tyr705 signalling pathways. PMID:28832962
Pharmacokinetic interactions and dosing rationale for antiepileptic drugs in adults and children. PMID:28815754
NAD replenishment with nicotinamide mononucleotide protects blood-brain barrier integrity and attenuates delayed tissue plasminogen activator-induced haemorrhagic transformation after cerebral ischaemia. PMID:28812311
Olodaterol shows anti-fibrotic efficacy in in vitro and in vivo models of pulmonary fibrosis. PMID:28810065
Single-dose pharmacokinetics of co-crystal of tramadol-celecoxib: Results of a four-way randomized open-label phase I clinical trial in healthy subjects. PMID:28810061
Olaparib protects cardiomyocytes against oxidative stress and improves graft contractility during the early phase after heart transplantation in rats. PMID:28806493
The role of 5-HT2B receptors in mitral valvulopathy: bone marrow mobilization of endothelial progenitors. PMID:28806488
Suppression of acute and anticipatory nausea by peripherally restricted fatty acid amide hydrolase inhibitor in animal models: role of PPARα and CB1 receptors. PMID:28805944
Pharmacological inhibition of focal segmental glomerulosclerosis-related, gain of function mutants of TRPC6 channels by semi-synthetic derivatives of larixol. PMID:28800680
Butyrate protects against disruption of the blood-milk barrier and moderates inflammatory responses in a model of mastitis induced by lipopolysaccharide. PMID:28800679
Levothyroxine enhances glucose clearance and blunts the onset of experimental type 1 diabetes mellitus in mice. PMID:28800677
Discovery and pharmacological characterization of a novel series of highly selective inhibitors of cyclin-dependent kinases 4 and 6 as anticancer agents. PMID:28800675
M-type K+ channels in peripheral nociceptive pathways. PMID:28800673
Epithelial desquamation observed in a phase I study of an oral cathepsin C inhibitor (GSK2793660). PMID:28800383
Antidote to cannabinoid intoxication: the CB1 receptor inverse agonist, AM251, reverses hypothermic effects of the CB1 receptor agonist, CB-13, in mice. PMID:28800377
Dried blood spots from finger prick facilitate therapeutic drug monitoring of adalimumab and anti-adalimumab in patients with inflammatory diseases. PMID:28791718
Using the affective bias test to predict drug-induced negative affect: implications for drug safety. PMID:28782244
Population pharmacokinetics of oxcarbazepine and its monohydroxy derivative in epileptic children. PMID:28771787
Metabolic profiling of murine plasma reveals eicosapentaenoic acid metabolites protecting against endothelial activation and atherosclerosis. PMID:28771708
Effects of centrally administered endocannabinoids and opioids on orofacial pain perception in rats. PMID:28771697
Cardioprotective effects of 5-hydroxymethylfurfural mediated by inhibition of L-type Ca2+ currents. PMID:28768052
Carbon monoxide released from its pharmacological donor, tricarbonyldichlororuthenium (II) dimer, accelerates the healing of pre-existing gastric ulcers. PMID:28768046
Renal toxicity and chemotherapy in children with cancer. PMID:28758697
Comparison of caffeine disposition following administration by oral solution (energy drink) and inspired powder (AeroShot) in human subjects. PMID:28758694
The toxicity of paracetamol-codeine combination in overdose is an unresolved issue. PMID:28758245
Antibiotic-induced dysbiosis of the microbiota impairs gut neuromuscular function in juvenile mice. PMID:28755521
Defining a Cancer Dependency Map. PMID:28753430
Inhibition of nuclear Wnt signalling: challenges of an elusive target for cancer therapy. PMID:28752891
Ameliorative effect of chlorpromazine hydrochloride on visceral hypersensitivity in rats: possible involvement of 5-HT2A receptor. PMID:28750135
Sodium channels and pain: from toxins to therapies. PMID:28749537
Inhibition of histone deacetylases sensitizes EGF receptor-TK inhibitor-resistant non-small-cell lung cancer cells to erlotinib in vitro and in vivo. PMID:28749535
Trimethylamine N-oxide: breathe new life. PMID:28745401
'Lnc'-ing Wnt in female reproductive cancers: therapeutic potential of long non-coding RNAs in Wnt signalling. PMID:28736855
FXa inhibition by rivaroxaban modifies mechanisms associated with the pathogenesis of human abdominal aortic aneurysms. PMID:28735510
Response to R-warfarin anticoagulant effect. PMID:28735507
Real-world complexity of atrial fibrillation treatment with oral anticoagulants: design and interpretation of pharmacoepidemiological studies. PMID:28734007
Population pharmacokinetics and exposure-response of trastuzumab emtansine in advanced breast cancer previously treated with ≥2 HER2-targeted regimens. PMID:28733983
Informatics Approaches for Predicting, Understanding, and Testing Cancer Drug Combinations. PMID:28730498
P2X receptor channels in chronic pain pathways. PMID:28728214
α9- and α7-containing receptors mediate the pro-proliferative effects of nicotine in the A549 adenocarcinoma cell line. PMID:28726253
Central amygdala relaxin-3/relaxin family peptide receptor 3 signalling modulates alcohol seeking in rats. PMID:28726252
Appropriateness of antiplatelet therapy for primary and secondary cardio- and cerebrovascular prevention in acutely hospitalized older people. PMID:28722184
Pharmacokinetics and safety of the anti-human cytomegalovirus drug letermovir in subjects with hepatic impairment. PMID:28722153
Methoxetamine affects brain processing involved in emotional response in rats. PMID:28718892
Montelukast reduces inhaled chlorine triggered airway hyperresponsiveness and airway inflammation in the mouse. PMID:28718891
Effect of gemfibrozil and rifampicin on the pharmacokinetics of selexipag and its active metabolite in healthy subjects. PMID:28715853
Ticagrelor mitigates ischaemia-reperfusion induced vascular endothelial dysfunction in healthy young males - a randomized, single-blinded study. PMID:28715608
Opioids out of control. PMID:28714109
ATR-101 inhibits cholesterol efflux and cortisol secretion by ATP-binding cassette transporters, causing cytotoxic cholesterol accumulation in adrenocortical carcinoma cells. PMID:28710789
Drugs and obstructive sleep apnoea. PMID:28707329
Melatonin receptors: molecular pharmacology and signalling in the context of system bias. PMID:28707298
A comparison between vitamin K antagonists and new oral anticoagulants. PMID:28703392
Wnt signalling pathways in chronic lymphocytic leukaemia and B-cell lymphomas. PMID:28703283
Pterostilbene reduces oxidative stress, prevents hypertrophy and preserves systolic function of right ventricle in cor pulmonale model. PMID:28703274
Population pharmacokinetics and electrocardiographic effects of dihydroartemisinin-piperaquine in healthy volunteers. PMID:28695570
Evaluating the antifibrotic potency of galunisertib in a human ex vivo model of liver fibrosis. PMID:28691737
Changes in the plasma membrane in metabolic disease: impact of the membrane environment on G protein-coupled receptor structure and function. PMID:28691227
Inhibition of hyaluronan synthesis attenuates pulmonary hypertension associated with lung fibrosis. PMID:28688167
Therapeutic concentrations of digitoxin inhibit endothelial focal adhesion kinase and angiogenesis induced by different growth factors. PMID:28688145
Diminazene aceturate prevents nephropathy by increasing glomerular ACE2 and AT2 receptor expression in a rat model of type1 diabetes. PMID:28688122
A physiologically based pharmacokinetic modelling approach to predict buprenorphine pharmacokinetics following intravenous and sublingual administration. PMID:28688108
NFAT-regulated cytokine gene expression during tacrolimus therapy early after renal transplantation. PMID:28686294
Food intake and darunavir plasma concentrations in people living with HIV in an outpatient setting. PMID:28686287
Drug repurposing screens and synergistic drug-combinations for infectious diseases. PMID:28685814
Correlation between human ether-a-go-go-related gene channel inhibition and action potential prolongation. PMID:28681507
Big conductance calcium-activated potassium channel openers control spasticity without sedation. PMID:28677901
Does a glass of Coke boost the exposure to imatinib in gastrointestinal stromal tumour patients after gastrectomy? PMID:28677263
Brain serotoninergic nervous system is involved in bombesin-induced frequent urination through brain 5-HT7 receptors in rats. PMID:28675470
Inhibition of microsomal PGE synthase-1 reduces human vascular tone by increasing PGI2 : a safer alternative to COX-2 inhibition. PMID:28675448
Predicting QRS and PR interval prolongations in humans using nonclinical data. PMID:28675424
Relevance of tissue specific subunit expression in channelopathies. PMID:28669898
D-512, a novel dopamine D2/3 receptor agonist, demonstrates greater anti-Parkinsonian efficacy than ropinirole in Parkinsonian rats. PMID:28667675
Translating advances in the molecular basis of schizophrenia into novel cognitive treatment strategies. PMID:28667666
The macrolide antibiotic renaissance. PMID:28664582
Quantitative disease progression model of α-1 proteinase inhibitor therapy on computed tomography lung density in patients with α-1 antitrypsin deficiency. PMID:28662542
α9-containing nicotinic acetylcholine receptors and the modulation of pain. PMID:28662295
AQX-1125, small molecule SHIP1 activator inhibits bleomycin-induced pulmonary fibrosis. PMID:28658529
Reverse pharmacogenomics: carbamazepine normalizes activation and attenuates thermal hyperexcitability of sensory neurons due to Nav 1.7 mutation I234T. PMID:28658526
Injury-induced maladaptation and dysregulation of calcium channel α2 δ subunit proteins and its contribution to neuropathic pain development. PMID:28646556
Inhibition of JNK signalling mediates PPARα-dependent protection against intrahepatic cholestasis by fenofibrate. PMID:28646549
Morin, a novel liver X receptor α/β dual antagonist, has potent therapeutic efficacy for nonalcoholic fatty liver diseases. PMID:28646531
Tofacitinib restores the inhibition of reverse cholesterol transport induced by inflammation: understanding the lipid paradox associated with rheumatoid arthritis. PMID:28646516
WMJ-8-B, a novel hydroxamate derivative, induces MDA-MB-231 breast cancer cell death via the SHP-1-STAT3-survivin cascade. PMID:28646512
The effects of advanced age and serum α1 -acid glycoprotein on docetaxel unbound exposure and dose-limiting toxicity in cancer patients. PMID:28640540
Comparison of effect sizes between enriched and nonenriched trials of analgesics for chronic musculoskeletal pain: a systematic review. PMID:28636752
A phase I trial of PRN1008, a novel reversible covalent inhibitor of Bruton's tyrosine kinase, in healthy volunteers. PMID:28636208
Understanding and improving photo-control of ion channels in nociceptors with azobenzene photo-switches. PMID:28635081
Neuroadaptations of presynaptic and postsynaptic GABAB receptor function in the paraventricular nucleus in response to chronic unpredictable stress. PMID:28635080
Prediction of sustained fetal toxicity induced by ketoprofen based on PK/PD analysis using human placental perfusion and rat toxicity data. PMID:28635050
Molecular regulation and pharmacological targeting of the β-catenin destruction complex. PMID:28634996
l-Homocysteine-induced cathepsin V mediates the vascular endothelial inflammation in hyperhomocysteinaemia. PMID:28631302
Hydrogen sulphide as a signalling molecule regulating physiopathological processes in gastrointestinal motility. PMID:28631296
Oleanolic acid derivative DKS26 exerts antidiabetic and hepatoprotective effects in diabetic mice and promotes glucagon-like peptide-1 secretion and expression in intestinal cells. PMID:28627773
Comparison of systemic pharmacodynamic effects of two combination pressurized metered dose inhalers that deliver salmeterol and fluticasone propionate. PMID:28626983
Glutamatergic regulation of cognition and functional brain connectivity: insights from pharmacological, genetic and translational schizophrenia research. PMID:28626937
The anti-migraine component of butterbur extracts, isopetasin, desensitizes peptidergic nociceptors by acting on TRPA1 cation channel. PMID:28622417
Using automated patch clamp electrophysiology platforms in pain-related ion channel research: insights from industry and academia. PMID:28622411
The long and winding road for selective androgen receptor modulators. PMID:28621446
Isoacteoside, a dihydroxyphenylethyl glycoside, exhibits anti-inflammatory effects through blocking toll-like receptor 4 dimerization. PMID:28616865
Contrasting effects of phosphatidylinositol 4,5-bisphosphate on cloned TMEM16A and TMEM16B channels. PMID:28616863
Loops D, E and G in the Drosophila Dα1 subunit contribute to high neonicotinoid sensitivity of Dα1-chicken β2 nicotinic acetylcholine receptor. PMID:28616862
The Arg-Phe-amide peptide 26RFa/glutamine RF-amide peptide and its receptor: IUPHAR Review 24. PMID:28613414
A novel individual-cell-based mathematical model based on multicellular tumour spheroids for evaluating doxorubicin-related delivery in avascular regions. PMID:28608595
Inhibition of human N- and T-type calcium channels by an ortho-phenoxyanilide derivative, MONIRO-1. PMID:28608537
Recent advances in the development of T-type calcium channel blockers for pain intervention. PMID:28608534
Heteromers of μ opioid and dopamine D1 receptors modulate opioid-induced locomotor sensitization in a dopamine-independent manner. PMID:28608532
Pretransplant 4β-hydroxycholesterol does not predict tacrolimus exposure or dose requirements during the first days after kidney transplantation. PMID:28603840
Compartmentalized cAMP responses to prostaglandin EP2 receptor activation in human airway smooth muscle cells. PMID:28603838
Using ChEMBL web services for building applications and data processing workflows relevant to drug discovery. PMID:28602100
The dynamic interaction between pain and opioid misuse. PMID:28602044
The fifth subunit of the (α4β2)2 β2 nicotinic ACh receptor modulates maximal ACh responses. PMID:28600847
Sex differences in the regulation of porcine coronary artery tone by perivascular adipose tissue: a role of adiponectin? PMID:28593738
Influence of opioids on immune function in patients with cancer pain: from bench to bedside. PMID:28593737
Initial anticoagulation in patients with pulmonary embolism: thrombolysis, unfractionated heparin, LMWH, fondaparinux, or DOACs? PMID:28593681
Characterization of functional μ opioid receptor turnover in rat locus coeruleus: an electrophysiological and immunocytochemical study. PMID:28589556
4β-Hydroxycholesterol level significantly correlates with steady-state serum concentration of the CYP3A4 substrate quetiapine in psychiatric patients. PMID:28585378
Blockade of the 5-HT transporter contributes to the behavioural, neuronal and molecular effects of cocaine. PMID:28585320
Reduced α4 subunit expression in α4+- and α4+- /β2+- nicotinic acetylcholine receptors alters α4β2 subtype up-regulation following chronic nicotine treatment. PMID:28585241
Melatonin in regulation of inflammatory pathways in rheumatoid arthritis and osteoarthritis: involvement of circadian clock genes. PMID:28585236
In vitro-in silico-based analysis of the dose-dependent in vivo oestrogenicity of the soy phytoestrogen genistein in humans. PMID:28585232
Fluoxetine and Raynaud's phenomenon: friend or foe? PMID:28580711
Large-Scale Prediction of Drug-Target Interaction: a Data-Centric Review. PMID:28577120
The β3 -adrenoceptor agonist mirabegron increases human atrial force through β1 -adrenoceptors: an indirect mechanism? PMID:28574581
Rationale for targeting the Wnt signalling modulator Dickkopf-1 for oncology. PMID:28574171
The p21-activated kinase 1 (Pak1) signalling pathway in cardiac disease: from mechanistic study to therapeutic exploration. PMID:28574147
Winding back Wnt signalling: potential therapeutic targets for treating gastric cancers. PMID:28568899
COX-2-selective inhibitors celecoxib and deracoxib modulate transient receptor potential vanilloid 3 channels. PMID:28567799
Cannabinoid CB1 /CB2 receptor agonists attenuate hyperactivity and body weight loss in a rat model of activity-based anorexia. PMID:28561272
Pharmacogenetic analysis of irreversible severe cisplatin-induced nephropathy: a case report of a 27-year-old woman. PMID:28560854
Privileged Structures Revisited. PMID:28558125
Treatment of spontaneous preterm labour with retosiban: a phase II pilot dose-ranging study. PMID:28556962
A pharmacokinetic-pharmacodynamic model predicting tumour growth inhibition after intermittent administration with the mTOR kinase inhibitor AZD8055. PMID:28556895
Novel selective PDE type 1 inhibitors cause vasodilatation and lower blood pressure in rats. PMID:28548283
Significant decreases in blood propofol concentrations during adrenalectomy for phaeochromocytoma. PMID:28548279
Combination therapy with telmisartan and parecoxib induces regression of endometriotic lesions. PMID:28548231
Endoplasmic reticulum stress in the heart: insights into mechanisms and drug targets. PMID:28548229
Single and combined effects of Δ9 -tetrahydrocannabinol and cannabidiol in a mouse model of chemotherapy-induced neuropathic pain. PMID:28548225
The saponin D39 blocks dissociation of non-muscular myosin heavy chain IIA from TNF receptor 2, suppressing tissue factor expression and venous thrombosis. PMID:28547925
Vitamin D receptor agonists regulate ocular developmental angiogenesis and modulate expression of dre-miR-21 and VEGF. PMID:28547797
Translation of WNT developmental programs into stem cell replacement strategies for the treatment of Parkinson's disease. PMID:28547771
The anaesthetized rabbit with acute atrioventricular block provides a new model for detecting drug-induced Torsade de Pointes. PMID:28547743
Effect of a single intravenous zoledronic acid administration on biomarkers of acute kidney injury (AKI) in patients with osteoporosis: a pilot study. PMID:28543687
When two is not better than one. PMID:28543530
The inward rectifier current inhibitor PA-6 terminates atrial fibrillation and does not cause ventricular arrhythmias in goat and dog models. PMID:28542844
Ibuprofen and diclofenac treatments reduce proliferation of pancreatic acinar cells upon inflammatory injury and mitogenic stimulation. PMID:28542719
Modulatory features of the novel spider toxin μ-TRTX-Df1a isolated from the venom of the spider Davus fasciatus. PMID:28542706
Prostaglandin E2 glyceryl ester is an endogenous agonist of the nucleotide receptor P2Y6. PMID:28539604
Last rolls of the yoyo: Assessing the human canonical protein count. PMID:28529709
Pharmacological interventions in the Wnt pathway: inhibition of Wnt secretion versus disrupting the protein-protein interfaces of nuclear factors. PMID:28521071
Gαs signalling of the CB1 receptor and the influence of receptor number. PMID:28516479
The Dickkopf1-cytoskeleton-associated protein 4 axis creates a novel signalling pathway and may represent a molecular target for cancer therapy. PMID:28514532
Protective effects of dioscin against cisplatin-induced nephrotoxicity via the microRNA-34a/sirtuin 1 signalling pathway. PMID:28514495
Fluoxetine and congenital malformations: a systematic review and meta-analysis of cohort studies. PMID:28513059
Free and total plasma concentrations of elvitegravir/cobicistat during pregnancy and postpartum: a case report. PMID:28512794
Assessment of effect of CYP3A inhibition, CYP induction, OATP1B inhibition, and high-fat meal on pharmacokinetics of the JAK1 inhibitor upadacitinib. PMID:28503781
Hydrogen sulfide pretreatment improves mitochondrial function in myocardial hypertrophy via a SIRT3-dependent manner. PMID:28503736
Optimizing the dose in cancer patients treated with imatinib, sunitinib and pazopanib. PMID:28500677
Modulation of Kv 11.1 (hERG) channels by 5-(((1H-indazol-5-yl)oxy)methyl)-N-(4-(trifluoromethoxy)phenyl)pyrimidin-2-amine (ITP-2), a novel small molecule activator. PMID:28500657
Stimulation of autophagy prevents intestinal mucosal inflammation and ameliorates murine colitis. PMID:28500644
Principles of pharmacological research of nutraceuticals. PMID:28500635
Selective κ receptor partial agonist HS666 produces potent antinociception without inducing aversion after i.c.v. administration in mice. PMID:28494108
R-warfarin anticoagulant effect. PMID:28493597
Natural alkaloid bouchardatine ameliorates metabolic disorders in high-fat diet-fed mice by stimulating the sirtuin 1/liver kinase B-1/AMPK axis. PMID:28493443
Design and validation of the first cell-impermeant melatonin receptor agonist. PMID:28493341
Response of Htr3a knockout mice to antidepressant treatment and chronic stress. PMID:28493335
Selectivity determinants of GPCR-G-protein binding. PMID:28489817
QT interval prolongation in opioid agonist treatment: analysis of continuous 12-lead electrocardiogram recordings. PMID:28488266
Oxidized low-density lipoprotein stimulates epithelial sodium channels in endothelial cells of mouse thoracic aorta. PMID:28480509
The pharmacokinetic interaction between ivacaftor and ritonavir in healthy volunteers. PMID:28477428
Persistent activation of α7 nicotinic ACh receptors associated with stable induction of different desensitized states. PMID:28477386
Cognitive deficits caused by prefrontal cortical and hippocampal neural disinhibition. PMID:28477384
α-Conotoxins active at α3-containing nicotinic acetylcholine receptors and their molecular determinants for selective inhibition. PMID:28477355
Peripheral inflammation affects modulation of nociceptive synaptic transmission in the spinal cord induced by N-arachidonoylphosphatidylethanolamine. PMID:28476070
ELAC (3,12-di-O-acetyl-8-O-tigloilingol), a plant-derived lathyrane diterpene, induces subventricular zone neural progenitor cell proliferation through PKCβ activation. PMID:28476069
Metformin and daclatasvir: absence of a pharmacokinetic-pharmacodynamic drug interaction in healthy volunteers. PMID:28474741
Mast cells mediate early neutrophil recruitment and exhibit anti-inflammatory properties via the formyl peptide receptor 2/lipoxin A4 receptor. PMID:28471519
Hydroxyeicosapentaenoic acids and epoxyeicosatetraenoic acids attenuate early occurrence of nonalcoholic fatty liver disease. PMID:28471490
Cytotoxic lymphocytes and atherosclerosis: significance, mechanisms and therapeutic challenges. PMID:28471481
Aprepitant and fosaprepitant drug interactions: a systematic review. PMID:28470980
Neurosteroid biosynthesis down-regulation and changes in GABAA receptor subunit composition: a biomarker axis in stress-induced cognitive and emotional impairment. PMID:28456011
Understanding structure-function relationships of the human neuronal acetylcholine receptor: insights from the first crystal structures of neuronal subunits. PMID:28452148
ZY15557, a novel, long acting inhibitor of dipeptidyl peptidase-4, for the treatment of Type 2 diabetes mellitus. PMID:28452143
Inhibition of transmembrane member 16A calcium-activated chloride channels by natural flavonoids contributes to flavonoid anticancer effects. PMID:28452066
Metoprolol-pridopidine drug-drug interaction and food effect assessments of pridopidine, a new drug for treatment of Huntington's disease. PMID:28449367
Predictive mechanisms linking brain opioids to chronic pain vulnerability and resilience. PMID:28449262
Safety, pharmacokinetics and pharmacological effects of the selective androgen receptor modulator, GSK2881078, in healthy men and postmenopausal women. PMID:28449232
Recent progress in the understanding of relaxin family peptides and their receptors. PMID:28447360
Dual cyclin-dependent kinase 4/6 inhibition by PD-0332991 induces apoptosis and senescence in oesophageal squamous cell carcinoma cells. PMID:28444744
Factors influencing biased agonism in recombinant cells expressing the human α1A -adrenoceptor. PMID:28444738
Chronic inhibition of fatty acid amide hydrolase by URB597 produces differential effects on cardiac performance in normotensive and hypertensive rats. PMID:28437860
Influence of inflammation and nitric oxide upon platelet aggregation following deposition of diesel exhaust particles in the airways. PMID:28437857
Inhibition of semicarbazide-sensitive amine oxidase/vascular adhesion protein-1 reduces lipopolysaccharide-induced neuroinflammation. PMID:28437839
Activation of AMP-activated protein kinase by metformin ablates angiotensin II-induced endoplasmic reticulum stress and hypertension in mice in vivo. PMID:28436023
Cross-species studies of cognition relevant to drug discovery: a translational approach. PMID:28432778
Protein S-sulfhydration by hydrogen sulfide in cardiovascular system. PMID:28432761
Tenapanor administration and the activity of the H+ -coupled transporter PepT1 in healthy volunteers. PMID:28432691
Sulfur-containing gaseous signal molecules, ion channels and cardiovascular diseases. PMID:28430359
Reactive oxygen species: key regulators in vascular health and diseases. PMID:28430357
Impact of adverse drug events and treatment satisfaction on patient adherence with antihypertensive medication - a study in ambulatory patients. PMID:28429533
Body weight, gender and pregnancy affect enantiomer-specific ketorolac pharmacokinetics. PMID:28429492
Lifestyle use of drugs by healthy people for enhancing cognition, creativity, motivation and pleasure. PMID:28427114
Pneumonia risk in asthma patients using inhaled corticosteroids: a quasi-cohort study. PMID:28425216
Head-to-head comparison of structurally unrelated dipeptidyl peptidase 4 inhibitors in the setting of renal ischemia reperfusion injury. PMID:28423178
The isoprenoid derivative N6 -benzyladenosine CM223 exerts antitumor effects in glioma patient-derived primary cells through the mevalonate pathway. PMID:28419419
Allostery at opioid receptors: modulation with small molecule ligands. PMID:28419415
Selective and state-dependent activation of TRESK (K2P 18.1) background potassium channel by cloxyquin. PMID:28419410
Individualising the dose of allopurinol in patients with gout. PMID:28417592
Dietary salt blunts vasodilation by stimulating epithelial sodium channels in endothelial cells from salt-sensitive Dahl rats. PMID:28409833
Glycogen phosphorylase inhibition improves beta cell function. PMID:28409826
Targeting inflammation to reduce cardiovascular disease risk: a realistic clinical prospect? PMID:28409825
A sphingosine-1-phosphate receptor type 1 agonist, ASP4058, suppresses intracranial aneurysm through promoting endothelial integrity and blocking macrophage transmigration. PMID:28409823
Nano-curcumin safely prevents streptozotocin-induced inflammation and apoptosis in pancreatic beta cells for effective management of Type 1 diabetes mellitus. PMID:28409821
Drug interactions and safety profiles with concomitant use of caspofungin and calcineurin inhibitors in allogeneic haematopoietic cell transplantation. PMID:28407449
Nitric oxide and hydrogen sulfide: the gasotransmitter paradigm of the vascular system. PMID:28407204
Adrenomedullin 2/intermedin: a putative drug candidate for treatment of cardiometabolic diseases. PMID:28407200
Mechanisms of drug-drug interaction between rifampicin and fusidic acid. PMID:28406539
A new nomenclature for classifying psychotropic drugs. PMID:28401576
Effect of P-glycoprotein inhibition at the blood-brain barrier on brain distribution of (R)-[11 C]verapamil in elderly vs. young subjects. PMID:28401570
Opioid system and human emotions. PMID:28394427
Trends in the prescription of novel oral anticoagulants in UK primary care. PMID:28390065
Investigation of the mycobacterial enzyme HsaD as a potential novel target for anti-tubercular agents using a fragment-based drug design approach. PMID:28380256
Targeting multiple opioid receptors - improved analgesics with reduced side effects? PMID:28378462
Oxytocin and opioid addiction revisited: old drug, new applications. PMID:28378414
Response to: 'Response to: Bodyweight-adjustments introduce significant correlations between CYP3A metrics and tacrolimus clearance'. PMID:28374426
Autoinhibitory properties of the parent but not of the N-oxide metabolite contribute to infusion rate-dependent voriconazole pharmacokinetics. PMID:28370390
Statins and polyneuropathy revisited: case-control study in Denmark, 1999-2013. PMID:28370351
Do antiepileptic drugs increase the risk of infectious diseases? A meta-analysis of placebo-controlled studies. PMID:28370224
Propofol induces excessive vasodilation of aortic rings by inhibiting protein kinase Cβ2 and θ in spontaneously hypertensive rats. PMID:28369981
Activation of α1A -adrenoceptors desensitizes the rat aorta response to phenylephrine through a neuronal NOS pathway, a mechanism lost with ageing. PMID:28369791
Immune checkpoint proteins: exploring their therapeutic potential to regulate atherosclerosis. PMID:28369782
Drug repurposing from the perspective of pharmaceutical companies. PMID:28369768
Multiple targets for flecainide action: implications for cardiac arrhythmogenesis. PMID:28369767
Vascular inflammation and low-density lipoproteins: is cholesterol the link? A lesson from the clinical trials. PMID:28369752
Olcegepant blocks neurogenic and non-neurogenic CGRPergic vasodepressor responses and facilitates noradrenergic vasopressor responses in pithed rats. PMID:28369749
The role of Hippo/yes-associated protein signalling in vascular remodelling associated with cardiovascular disease. PMID:28369744
μ opioid receptor, social behaviour and autism spectrum disorder: reward matters. PMID:28369738
Biased agonism and allosteric modulation of G protein-coupled receptor 183 - a 7TM receptor also known as Epstein-Barr virus-induced gene 2. PMID:28369721
The gap junction modifier ZP1609 decreases cardiomyocyte hypercontracture following ischaemia/reperfusion independent from mitochondrial connexin 43. PMID:28369703
Isorhapontigenin, a bioavailable dietary polyphenol, suppresses airway epithelial cell inflammation through a corticosteroid-independent mechanism. PMID:28369685
A brief pictorial and historical introduction to guaiacum - from a putative cure for syphilis to an actual screening method for colorectal cancer. PMID:28349597
PubChem BioAssay: A Decade's Development toward Open High-Throughput Screening Data Sharing. PMID:28346087
A multinational, drug utilization study to investigate the use of dexmedetomidine (Dexdor®) in clinical practice in the EU. PMID:28345249
Pharmacogenomics of off-target adverse drug reactions. PMID:28345177
Pharmacovigilance database search discloses ClC-K channels as a novel target of the AT1 receptor blockers valsartan and olmesartan. PMID:28334417
The epigenetic landscape related to reactive oxygen species formation in the cardiovascular system. PMID:28332701
Determining Cysteines Available for Covalent Inhibition Across the Human Kinome. PMID:28326775
Risk of myocardial infarction in patients with atrial fibrillation using vitamin K antagonists, aspirin or direct acting oral anticoagulants. PMID:28326589
Current and future therapies for addressing the effects of inflammation on HDL cholesterol metabolism. PMID:28326542
Constitutive androstane receptor regulates the intestinal mucosal response to injury. PMID:28320072
Dexpramipexole improves bioenergetics and outcome in experimental stroke. PMID:28320070
D-β-hydroxybutyrate promotes functional recovery and relieves pain hypersensitivity in mice with spinal cord injury. PMID:28320049
Effects of ranolazine in a model of doxorubicin-induced left ventricle diastolic dysfunction. PMID:28320043
Calcium channel modulation as a target in chronic pain control. PMID:28320042
Monoclonal antibodies in the treatment of multiple sclerosis: emergence of B-cell-targeted therapies. PMID:28319650
CGRP receptor activity in mice with global expression of human receptor activity modifying protein 1. PMID:28317098
The TIR/BB-loop mimetic AS-1 prevents non-alcoholic steatohepatitis and hepatic insulin resistance by inhibiting NLRP3-ASC inflammasome activation. PMID:28306139
Interruption to antiplatelet therapy early after acute ischaemic stroke: a nested case-control study. PMID:28299795
TC Mps1 12, a novel Mps1 inhibitor, suppresses the growth of hepatocellular carcinoma cells via the accumulation of chromosomal instability. PMID:28299790
Trafficking and other regulatory mechanisms for organic anion transporting polypeptides and organic anion transporters that modulate cellular drug and xenobiotic influx and that are dysregulated in disease. PMID:28299773
Immunology proves a great success for treating systemic autoimmune diseases - a perspective on immunopharmacology: IUPHAR Review 23. PMID:28299772
CCL20 neutralization by a monoclonal antibody in healthy subjects selectively inhibits recruitment of CCR6+ cells in an experimental suction blister. PMID:28295451
Use of oral antidiabetic agents and risk of community-acquired pneumonia: a nested case-control study. PMID:28294379
IL-21 promotes myocardial ischaemia/reperfusion injury through the modulation of neutrophil infiltration. PMID:28294304
Proteins and chemical chaperones involved in neuronal nicotinic receptor expression and function: an update. PMID:28294298
Cannabidiol regulation of emotion and emotional memory processing: relevance for treating anxiety-related and substance abuse disorders. PMID:28268256
Psychotropics and weak opioid analgesics in plasma samples of older hip fracture patients - detection frequencies and consistency with drug records. PMID:28268245
Insights into the function of opioid receptors from molecular dynamics simulations of available crystal structures. PMID:28266020
Hippocampal α7 nicotinic ACh receptors contribute to modulation of depression-like behaviour in C57BL/6J mice. PMID:28264149
Exposure of adolescent mice to 3,4-methylenedioxypyrovalerone increases the psychostimulant, rewarding and reinforcing effects of cocaine in adulthood. PMID:28262947
The pro-cognitive mechanisms of physical exercise in people with schizophrenia. PMID:28261797
Nicotinic acetylcholine receptors at the single-channel level. PMID:28261794
Signalling mechanisms underlying doxorubicin and Nox2 NADPH oxidase-induced cardiomyopathy: involvement of mitofusin-2. PMID:28261787
GABA-ρ receptors: distinctive functions and molecular pharmacology. PMID:28258627
The anti-hepatic fibrosis effects of dihydrotanshinone I are mediated by disrupting the yes-associated protein and transcriptional enhancer factor D2 complex and stimulating autophagy. PMID:28257144
Pro-contractile effects of perivascular fat in health and disease. PMID:28257140
Curcuminoid EF24 enhances the anti-tumour activity of Akt inhibitor MK-2206 through ROS-mediated endoplasmic reticulum stress and mitochondrial dysfunction in gastric cancer. PMID:28255993
Plant sterol enriched functional food and atherosclerosis. PMID:28253422
Should we treat very large paracetamol overdose differently? PMID:28252212
Pathological overproduction: the bad side of adenosine. PMID:28252203
Pharmacokinetics of tranexamic acid in neonates and infants undergoing cardiac surgery. PMID:28245519
WNT signalling events near the cell membrane and their pharmacological targeting for the treatment of cancer. PMID:28244067
Transient Receptor Potential Cation Channel Subfamily M Member 8 channels mediate the anti-inflammatory effects of eucalyptol. PMID:28240768
Early signal of diverted use of tropicamide eye drops in France. PMID:28239898
Population pharmacokinetics of rituximab in patients with diffuse large B-cell lymphoma and association with clinical outcome. PMID:28239897
Protein phosphatase 2A regulation of markers of extracellular matrix remodelling in hepatocellular carcinoma cells: functional consequences for tumour invasion. PMID:28239848
Inhibition of 6-phosphofructo-2-kinase suppresses fibroblast-like synoviocytes-mediated synovial inflammation and joint destruction in rheumatoid arthritis. PMID:28239846
Stimulation of Na+ -K+ -pump currents by epithelial nicotinic receptors in rat colon. PMID:28239845
Adiponectin improves endothelial function in mesenteric arteries of rats fed a high-fat diet: role of perivascular adipose tissue. PMID:28236429
Antigenic burden and serum IgG concentrations influence rituximab pharmacokinetics in rheumatoid arthritis patients. PMID:28230269
Evaluation of the immunogenicity of the dabigatran reversal agent idarucizumab during Phase I studies. PMID:28230262
Metformin attenuates angiotensin II-induced TGFβ1 expression by targeting hepatocyte nuclear factor-4-α. PMID:28230250
Elastase-2, an angiotensin II-generating enzyme, contributes to increased angiotensin II in resistance arteries of mice with myocardial infarction. PMID:28222221
An anti-nicotinic cognitive challenge model using mecamylamine in comparison with the anti-muscarinic cognitive challenge using scopolamine. PMID:28217868
Zebrafish models in neuropsychopharmacology and CNS drug discovery. PMID:28217866
Calcium signalling through L-type calcium channels: role in pathophysiology of spinal nociceptive transmission. PMID:28214378
Utilizing melatonin to combat bacterial infections and septic injury. PMID:28213968
A bosentan pharmacokinetic study to investigate dosing regimens in paediatric patients with pulmonary arterial hypertension: FUTURE-3. PMID:28213957
PGE2 /EP4 receptor attenuated mucosal injury via β-arrestin1/Src/EGFR-mediated proliferation in portal hypertensive gastropathy. PMID:28213942
Population pharmacokinetic and exposure simulation analysis for cediranib (AZD2171) in pooled Phase I/II studies in patients with cancer. PMID:28213941
Targeting phosphodiesterase 5 as a therapeutic option against myocardial ischaemia/reperfusion injury and for treating heart failure. PMID:28213937
Opportunities for the repurposing of PARP inhibitors for the therapy of non-oncological diseases. PMID:28213892
Opioids and the immune system - friend or foe. PMID:28213891
Risk of major bleeding and stroke associated with the use of vitamin K antagonists, nonvitamin K antagonist oral anticoagulants and aspirin in patients with atrial fibrillation: a cohort study. PMID:28205318
Orthosteric and allosteric potentiation of heteromeric neuronal nicotinic acetylcholine receptors. PMID:28199738
Phenolic 1,3-diketones attenuate lipopolysaccharide-induced inflammatory response by an alternative magnesium-mediated mechanism. PMID:28198010
Identification of the anti-mycobacterial functional properties of piperidinol derivatives. PMID:28195652
Significance of angiotensin 1-7 coupling with MAS1 receptor and other GPCRs to the renin-angiotensin system: IUPHAR Review 22. PMID:28194766
The effect of co-trimoxazole on serum potassium concentration: safety evaluation of a randomized controlled trial. PMID:28192629
Dapagliflozin-lowered blood glucose reduces respiratory Pseudomonas aeruginosa infection in diabetic mice. PMID:28192604
Comparing intravenous and oral proton pump inhibitor therapy for bleeding peptic ulcers following endoscopic management: a systematic review and meta-analysis. PMID:28181291
Effects of linagliptin on human immortalized podocytes: a cellular system to study dipeptidyl-peptidase 4 inhibition. PMID:28177527
Broad spectrum efficacy with LY2969822, an oral prodrug of metabotropic glutamate 2/3 receptor agonist LY2934747, in rodent pain models. PMID:28177520
Hypoalbuminaemia and decreased midazolam clearance in terminally ill adult patients, an inflammatory effect? PMID:28177137
A population pharmacokinetic model of AT9283 in adults and children to predict the maximum tolerated dose in children with leukaemia. PMID:28177130
Identification of novel inhibitors of the amino acid transporter B0 AT1 (SLC6A19), a potential target to induce protein restriction and to treat type 2 diabetes. PMID:28176326
Response to: 'Bodyweight-adjustments introduce significant correlations between CYP3A metrics and tacrolimus clearance'. PMID:28168728
Effect of ezetimibe on plasma adipokines: a systematic review and meta-analysis. PMID:28166606
Homology-guided mutational analysis reveals the functional requirements for antinociceptive specificity of collapsin response mediator protein 2-derived peptides. PMID:28161890
Identification and pharmacological characterization of succinate receptor agonists. PMID:28160606
Cytochrome P450-mediated interaction between perazine and risperidone: implications for antipsychotic polypharmacy. PMID:28160505
Population pharmacokinetics and site of action exposures of veliparib with topotecan plus carboplatin in patients with haematological malignancies. PMID:28156017
Evaluation of single and multiple doses of a novel mGlu2 agonist, a potential antipsychotic therapy, in healthy subjects. PMID:28156011
Why standards are useful for predicting doses. PMID:28155239
Role of PVAT in coronary atherosclerosis and vein graft patency: friend or foe? PMID:28150299
Exercise effects on perivascular adipose tissue: endocrine and paracrine determinants of vascular function. PMID:28147449
The CYP3A biomarker 4β-hydroxycholesterol does not improve tacrolimus dose predictions early after kidney transplantation. PMID:28146606
The clinically used PARP inhibitor olaparib improves organ function, suppresses inflammatory responses and accelerates wound healing in a murine model of third-degree burn injury. PMID:28146604
Pharmacological characterization of the excitatory 'Cys-loop' GABA receptor family in Caenorhabditis elegans. PMID:28146602
Investigation of the predictive validity of laser-EPs in normal, UVB-inflamed and capsaicin-irritated skin with four analgesic compounds in healthy volunteers. PMID:28139023
Dynamic population pharmacokinetic-pharmacodynamic modelling and simulation supports similar efficacy in glycosylated haemoglobin response with once or twice-daily dosing of canagliflozin. PMID:28138980
Role of inducible nitric oxide synthase in endothelium-independent relaxation to raloxifene in rat aorta. PMID:28138957
Pharmacokinetics, safety, tolerability and immunogenicity of FKB327, a new biosimilar medicine of adalimumab/Humira, in healthy subjects. PMID:28133772
Inhibition of CYP2D6 with low dose (5 mg) paroxetine in patients with high 10-hydroxynortriptyline serum levels - a review of routine practice. PMID:28133768
Exposure-response analysis after subcutaneous administration of RBP-7000, a once-a-month long-acting Atrigel formulation of risperidone. PMID:28133766
Crystal Structure of an LSD-Bound Human Serotonin Receptor. PMID:28129538
Pharmacological inhibition of complement C5a-C5a1 receptor signalling ameliorates disease pathology in the hSOD1G93A mouse model of amyotrophic lateral sclerosis. PMID:28128456
Suppression of carboxylesterases by imatinib mediated by the down-regulation of pregnane X receptor. PMID:28128444
A key role for tetrahydrobiopterin-dependent endothelial NOS regulation in resistance arteries: studies in endothelial cell tetrahydrobiopterin-deficient mice. PMID:28128438
Schisandrol B protects against cholestatic liver injury through pregnane X receptors. PMID:28128437
Bisperoxovandium (pyridin-2-squaramide) targets both PTEN and ERK1/2 to confer neuroprotection. PMID:28127755
Crosstalk between sphingolipids and vitamin D3: potential role in the nervous system. PMID:28127747
5-fluorouracil causes endothelial cell senescence: potential protective role of glucagon-like peptide 1. PMID:28127745
Pharmacokinetics and pharmacodynamics of single doses of rivaroxaban in obese patients prior to and after bariatric surgery. PMID:28121368
Genetic determinants of anthracycline cardiotoxicity - ready for the clinic? PMID:28120432
Efficacy of olanzapine for the prophylaxis of chemotherapy-induced nausea and vomiting: a meta-analysis. PMID:28112422
Comparative cardiovascular risks of dipeptidyl peptidase 4 inhibitors with other second- and third-line antidiabetic drugs in patients with type 2 diabetes. PMID:28109184
A novel dual amylin and calcitonin receptor agonist, KBP-089, induces weight loss through a reduction in fat, but not lean mass, while improving food preference. PMID:28109166
β-Caryophyllene protects against alcoholic steatohepatitis by attenuating inflammation and metabolic dysregulation in mice. PMID:28107775
Novel putative pharmacological therapies to protect the right ventricle in pulmonary hypertension: a review of current literature. PMID:28099680
Identification of cellular targets involved in cardiac failure caused by PKI in oncology: an approach combining pharmacovigilance and pharmacodynamics. PMID:28098949
Morroniside, a secoiridoid glycoside from Cornus officinalis, attenuates neuropathic pain by activation of spinal glucagon-like peptide-1 receptors. PMID:28098360
The evolution of regulators of G protein signalling proteins as drug targets - 20 years in the making: IUPHAR Review 21. PMID:28098342
Pharmacokinetics of first-line antitubercular drugs in plasma and PBMCs. PMID:28097677
Endothelin-1 and its receptors on haemorrhoidal tissue: a potential site for therapeutic intervention. PMID:28095606
Potent effects of dioscin against pancreatic cancer via miR-149-3P-mediated inhibition of the Akt1 signalling pathway. PMID:28095588
Chronic drug-induced effects on contractile motion properties and cardiac biomarkers in human induced pluripotent stem cell-derived cardiomyocytes. PMID:28094846
Improved fluorescence assays to measure the defects associated with F508del-CFTR allow identification of new active compounds. PMID:28094839
Adverse reactions to dietary supplements containing red yeast rice: assessment of cases from the Italian surveillance system. PMID:28093797
Ribosomal protein S3 gene silencing protects against experimental allergic asthma. PMID:28093718
Discrepancies in paper by Chiam et al.: The haemodynamic effects of intravenous paracetamol. PMID:28090696
The impact of CES1 genotypes on the pharmacokinetics of methylphenidate in healthy Danish subjects. PMID:28087982
Rapid antidepressant effect of ketamine correlates with astroglial plasticity in the hippocampus. PMID:28087979
Lack of effect of oral cabotegravir on the pharmacokinetics of a levonorgestrel/ethinyl oestradiol-containing oral contraceptive in healthy adult women. PMID:28087972
Dose evaluation of lamivudine in human immunodeficiency virus-infected children aged 5 months to 18 years based on a population pharmacokinetic analysis. PMID:28079918
Inhibition of matrix metalloproteinase-9 by a barbiturate-nitrate hybrid ameliorates dextran sulphate sodium-induced colitis: effect on inflammation-related genes. PMID:28079248
Pharmacokinetics of obinutuzumab in Chinese patients with B-cell lymphomas. PMID:28072473
Genistein and tyrphostin AG556 decrease ultra-rapidly activating delayed rectifier K+ current of human atria by inhibiting EGF receptor tyrosine kinase. PMID:28072464
Safety profile of the direct oral anticoagulants: an analysis of the WHO database of adverse drug reactions. PMID:28071818
Aspirin-triggered lipoxin A4 inhibits atherosclerosis progression in apolipoprotein E-/- mice. PMID:28071789
Functional and cardioprotective effects of simultaneous and individual activation of protein kinase A and Epac. PMID:28071786
Bioactive polyphenols and cardiovascular disease: chemical antagonists, pharmacological agents or xenobiotics that drive an adaptive response? PMID:28071785
Perivascular adipose tissue inflammation in vascular disease. PMID:28063251
Novel approaches to the treatment of bacterial biofilm infections. PMID:28063237
Bronchopulmonary pharmacokinetics of (R)-salbutamol and (S)-salbutamol enantiomers in pulmonary epithelial lining fluid and lung tissue of horses. PMID:28061018
Effect of hypercholesterolaemia on myocardial function, ischaemia-reperfusion injury and cardioprotection by preconditioning, postconditioning and remote conditioning. PMID:28060997
Restoration of perivascular adipose tissue function in diet-induced obese mice without changing bodyweight. PMID:28055105
Canonical hedgehog signalling regulates hepatic stellate cell-mediated angiogenesis in liver fibrosis. PMID:28052321
Treatment and management of chronic fatigue syndrome/myalgic encephalomyelitis: all roads lead to Rome. PMID:28052319
Readapting the adaptive immune response - therapeutic strategies for atherosclerosis. PMID:28052311
Donor CYP3A5 genotype influences tacrolimus disposition on the first day after paediatric liver transplantation. PMID:28044353
Effect of type 2 diabetes mellitus on the pharmacokinetics and transplacental transfer of nifedipine in hypertensive pregnant women. PMID:28042936
Lack of respiratory depression in paracetamol-codeine combination overdoses. PMID:28035699
Selection and early clinical evaluation of the brain-penetrant 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitor UE2343 (Xanamem™). PMID:28012176
miR-15b mediates oxaliplatin-induced chronic neuropathic pain through BACE1 down-regulation. PMID:28012171
Structural insight to mutation effects uncover a common allosteric site in class C GPCRs. PMID:28011766
Population pharmacokinetics and exposure-response of osimertinib in patients with non-small cell lung cancer. PMID:28009438
Serelaxin in clinical development: past, present and future. PMID:28009437
Pharmacological characterization of N-[(2S)-5-(6-fluoro-3-pyridinyl)-2, 3-dihydro-1H-inden-2-yl]-2-propanesulfonamide: a novel, clinical AMPA receptor positive allosteric modulator. PMID:28009436
Anti-CD22 and anti-CD79b antibody-drug conjugates preferentially target proliferating B cells. PMID:28009435
Bodyweight-adjustments introduce significant correlations between CYP3A metrics and tacrolimus clearance. PMID:28008657
Variability in response to albuminuria-lowering drugs: true or random? PMID:28002889
Cholesterol metabolism: a potential therapeutic target in Mycobacteria. PMID:28002883
Pharmacokinetics and safety of a single dose of the novel necrosis inhibitor LC28-0126 in healthy male subjects. PMID:28002882
Outcomes from massive paracetamol overdose: a retrospective observational study. PMID:28002875
Do KV 7.1 channels contribute to control of arterial vascular tone? PMID:28000293
Population pharmacokinetics of temsirolimus and sirolimus in children with recurrent solid tumours: a report from the Children's Oncology Group. PMID:28000286
Prediction of serum theophylline concentrations and cytochrome P450 1A2 activity by analyzing urinary metabolites in preterm infants. PMID:27995649
Is there potential for therapeutic drug monitoring of biologic agents in rheumatoid arthritis? PMID:27990682
Pharmacokinetics and pharmacodynamics of intrathecally administered Xen2174, a synthetic conopeptide with norepinephrine reuptake inhibitor and analgesic properties. PMID:27987228
Inhibiting thyrotropin/insulin-like growth factor 1 receptor crosstalk to treat Graves' ophthalmopathy: studies in orbital fibroblasts in vitro. PMID:27987211
Anti-anhedonic effect of selective serotonin reuptake inhibitors with affinity for sigma-1 receptors in picrotoxin-treated mice. PMID:27987210
Perivascular adipose tissue as a regulator of vascular disease pathogenesis: identifying novel therapeutic targets. PMID:27976387
Assessment of pharmacokinetic interaction between rilotumumab and epirubicin, cisplatin and capecitabine (ECX) in a Phase 3 study in gastric cancer. PMID:27966237
Tacrolimus dose requirements in paediatric renal allograft recipients are characterized by a biphasic course determined by age and bone maturation. PMID:27966227
The impact of olodaterol on the risk of mortality and serious adverse events: a systematic review and meta-analysis. PMID:27957746
Interindividual and interethnic variability in drug disposition: polymorphisms in organic anion transporting polypeptide 1B1 (OATP1B1; SLCO1B1). PMID:27936281
Anti-atherosclerotic effect of the angiotensin 1-7 mimetic AVE0991 is mediated by inhibition of perivascular and plaque inflammation in early atherosclerosis. PMID:27935022
Relaxin-like peptides in male reproduction - a human perspective. PMID:27933606
Chemoresistant lung cancer stem cells display high DNA repair capability to remove cisplatin-induced DNA damage. PMID:27933604
Increased mitochondrial ROS generation mediates the loss of the anti-contractile effects of perivascular adipose tissue in high-fat diet obese mice. PMID:27930804
AP39, a mitochondria-targeting hydrogen sulfide (H2 S) donor, protects against myocardial reperfusion injury independently of salvage kinase signalling. PMID:27930802
Evaluating beneficial drug effects in a non-interventional setting: a review of effectiveness studies based on Swedish Prescribed Drug Register data. PMID:27928842
Targeting the hard to reach: challenges and novel strategies in the treatment of intracellular bacterial infections. PMID:27925153
The neuropeptide cortistatin attenuates experimental autoimmune myocarditis via inhibition of cardiomyogenic T cell-driven inflammatory responses. PMID:27922195
Pharmacodynamic response profiles of anxiolytic and sedative drugs. PMID:27922194
Relaxin family peptides: structure-activity relationship studies. PMID:27922185
Sitagliptin reduces inflammation, fibrosis and preserves diastolic function in a rat model of heart failure with preserved ejection fraction. PMID:27922176
Statins and mortality: the untold story. PMID:27921324
Cardiac effects of amiselimod compared with fingolimod and placebo: results of a randomised, parallel-group, phase I study in healthy subjects. PMID:27921320
The orphan G protein-coupled receptor GPR139 is activated by the peptides: Adrenocorticotropic hormone (ACTH), α-, and β-melanocyte stimulating hormone (α-MSH, and β-MSH), and the conserved core motif HFRW. PMID:27916541
mutLBSgeneDB: mutated ligand binding site gene DataBase. PMID:27907895
Characterization of adverse drug reactions causing admission to an intensive care unit. PMID:27905143
Pharos: Collating protein information to shed light on the druggable genome. PMID:27903890
PubChem BioAssay: 2017 update. PMID:27899599
The ChEMBL database in 2017. PMID:27899562
Extended-release niacin increases anti-apolipoprotein A-I antibodies that block the antioxidant effect of high-density lipoprotein-cholesterol: the EXPLORE clinical trial. PMID:27891663
Cannabimimetic phytochemicals in the diet - an evolutionary link to food selection and metabolic stress adaptation? PMID:27891602
Clemizole hydrochloride blocks cardiac potassium currents stably expressed in HEK 293 cells. PMID:27886373
Investigating interactions between epicardial adipose tissue and cardiac myocytes: what can we learn from different approaches? PMID:27882550
Gene therapy with mesenchymal stem cells expressing IFN-ß ameliorates neuroinflammation in experimental models of multiple sclerosis. PMID:27882538
Neurochemical and behavioural effects of hypidone hydrochloride (YL-0919): a novel combined selective 5-HT reuptake inhibitor and partial 5-HT1A agonist. PMID:27882537
Aprepitant in pediatric patients using moderate and highly emetogenic protocols: a systematic review and meta-analyses of randomized controlled trials. PMID:27868231
Pharmacokinetic interaction between taxanes and amiodarone leading to severe toxicity. PMID:27868228
Endogenous lysophosphatidic acid (LPA1 ) receptor agonists demonstrate ligand bias between calcium and ERK signalling pathways in human lung fibroblasts. PMID:27864940
Effect of sphingosine kinase modulators on interleukin-1β release, sphingosine 1-phosphate receptor 1 expression and experimental autoimmune encephalomyelitis. PMID:27864936
Biomarkers of oxidative and nitro-oxidative stress: conventional and novel approaches. PMID:27864827
The use of a battery of pain models to detect analgesic properties of compounds: a two-part four-way crossover study. PMID:27862179
The effect of inflammation on voriconazole trough concentrations in children. PMID:27862167
In vitro and physiologically-based pharmacokinetic based assessment of drug-drug interaction potential of canagliflozin. PMID:27862160
Afzelin ameliorates D-galactosamine and lipopolysaccharide-induced fulminant hepatic failure by modulating mitochondrial quality control and dynamics. PMID:27861739
Antidepressant-like effects of fenofibrate in mice via the hippocampal brain-derived neurotrophic factor signalling pathway. PMID:27861729
First-in-human randomized study of bimekizumab, a humanized monoclonal antibody and selective dual inhibitor of IL-17A and IL-17F, in mild psoriasis. PMID:27859546
Drug-specific hypophosphatemia and hypersensitivity reactions following different intravenous iron infusions. PMID:27859495
Effect of ketoconazole, a strong CYP3A inhibitor, on the pharmacokinetics of venetoclax, a BCL-2 inhibitor, in patients with non-Hodgkin lymphoma. PMID:27859472
A novel assay to assess the effect of pharmaceutical compounds on the differentiation of podocytes. PMID:27858997
Size distribution of function-based human gene sets and the split-merge model. PMID:27853602
Xenobiotic-metabolizing enzymes in Bacillus anthracis: molecular and functional analysis of a truncated arylamine N-acetyltransferase isozyme. PMID:27846346
Novel Agonist Bioisosteres and Common Structure-Activity Relationships for The Orphan G Protein-Coupled Receptor GPR139. PMID:27830715
Population pharmacokinetics of rifampicin in adult patients with osteoarticular infections: interaction with fusidic acid. PMID:27813241
New actions of an old friend: perivascular adipose tissue's adrenergic mechanisms. PMID:27813085
Venlafaxine and oxycodone have different effects on spinal and supraspinal activity in man: a somatosensory evoked potential study. PMID:27808426
Hydrogen peroxide preferentially activates capsaicin-sensitive high threshold afferents via TRPA1 channels in the guinea pig bladder. PMID:27792844
Randomized, controlled, multicentre clinical trial of the antipyretic effect of intravenous paracetamol in patients admitted to hospital with infection. PMID:27792836
Biphasic effects of propranolol on tumour growth in B16F10 melanoma-bearing mice. PMID:27792834
GP2015, a proposed etanercept biosimilar: Pharmacokinetic similarity to its reference product and comparison of its autoinjector device with prefilled syringes. PMID:27790726
DrugCentral: online drug compendium. PMID:27789690
Central nervous system toxicity of mefenamic acid overdose compared with other NSAIDs: an analysis of cases reported to the United Kingdom National Poisons Information Service. PMID:27785820
The role of apolipoprotein N-acyl transferase, Lnt, in the lipidation of factor H binding protein of Neisseria meningitidis strain MC58 and its potential as a drug target. PMID:27784136
Maturation of oxycodone pharmacokinetics in neonates and infants: Oxycodone and its metabolites in plasma and urine. PMID:27780305
Pharmacokinetics and pharmacodynamics of a new highly concentrated intranasal midazolam formulation for conscious sedation. PMID:27780297
The use of incretins and fractures - a meta-analysis on population-based real life data. PMID:27780288
A Phase I study to determine the pharmacokinetic profile, safety and tolerability of sildenafil (Revatio® ) in cardiac surgery: the REVAKI-1 study. PMID:27779776
The suppression of bromodomain and extra-terminal domain inhibits vascular inflammation by blocking NF-κB and MAPK activation. PMID:27774624
Distribution, physiology and pharmacology of relaxin-3/RXFP3 systems in brain. PMID:27774604
Open PHACTS computational protocols for in silico target validation of cellular phenotypic screens: knowing the knowns. PMID:27774140
Synaptic Zn2+ and febrile seizure susceptibility. PMID:27771943
Synthetic non-peptide low molecular weight agonists of the relaxin receptor 1. PMID:27771940
Sertraline use in the first trimester and risk of congenital anomalies: a systemic review and meta-analysis of cohort studies. PMID:27770542
Scaling clearance in paediatric pharmacokinetics: All models are wrong, which are useful? PMID:27767204
Celastrol prevents cadmium-induced neuronal cell death by blocking reactive oxygen species-mediated mammalian target of rapamycin pathway. PMID:27764525
Effect of opicapone multiple-dose regimens on levodopa pharmacokinetics. PMID:27763682
Theory-based pharmacokinetics and pharmacodynamics of S- and R-warfarin and effects on international normalized ratio: influence of body size, composition and genotype in cardiac surgery patients. PMID:27763679
The role of perivascular adipose tissue in obesity-induced vascular dysfunction. PMID:27761903
Physiologically relevant binding affinity quantification of monoclonal antibody PF-00547659 to mucosal addressin cell adhesion molecule for in vitro in vivo correlation. PMID:27760281
The peptide Phα1β, from spider venom, acts as a TRPA1 channel antagonist with antinociceptive effects in mice. PMID:27759880
The SPARC protein: an overview of its role in lung cancer and pulmonary fibrosis and its potential role in chronic airways disease. PMID:27759879
Adverse events associated with interactions with dietary and herbal supplements among inpatients. PMID:27759172
Snapshot: implications for melatonin in endoplasmic reticulum homeostasis. PMID:27759160
The pharmacokinetics and pharmacodynamics of mycophenolate mofetil in younger and elderly renal transplant recipients. PMID:27753146
Polymorphisms in ABCB1 and CYP19A1 genes affect anastrozole plasma concentrations and clinical outcomes in postmenopausal breast cancer patients. PMID:27747906
Antioxidants from black and green tea: from dietary modulation of oxidative stress to pharmacological mechanisms. PMID:27747873
Comparisons between perivascular adipose tissue and the endothelium in their modulation of vascular tone. PMID:27747871
Amino acid transporter SLC6A14 is a novel and effective drug target for pancreatic cancer. PMID:27747870
Impact of concomitant medications on obstructive sleep apnoea. PMID:27735059
Effects of policy interventions on the introduction of novel oral anticoagulants in Stockholm: an interrupted time series analysis. PMID:27730670
Biomarker-guided clinical development of the first-in-class anti-inflammatory FPR2/ALX agonist ACT-389949. PMID:27730665
The potential health effects of dietary phytoestrogens. PMID:27723080
Development of a stretch-induced neurotrauma model for medium-throughput screening in vitro: identification of rifampicin as a neuroprotectant. PMID:27723079
Characterization of human cytochrome P450 mediated bioactivation of amodiaquine and its major metabolite N-desethylamodiaquine. PMID:27718269
Pharmacological mechanisms underlying the cardiovascular effects of the "bath salt" constituent 3,4-methylenedioxypyrovalerone (MDPV). PMID:27714779
Trastuzumab cardiotoxicity: from clinical trials to experimental studies. PMID:27714776
Histamine H4 receptor agonist-induced relief from painful peripheral neuropathy is mediated by inhibition of spinal neuroinflammation and oxidative stress. PMID:27714773
Amiselimod, a novel sphingosine 1-phosphate receptor-1 modulator, has potent therapeutic efficacy for autoimmune diseases, with low bradycardia risk. PMID:27714763
Role of oxidative stress in oxaliplatin-induced enteric neuropathy and colonic dysmotility in mice. PMID:27714760
The protective effect of the natural compound hesperetin against fulminant hepatitis in vivo and in vitro. PMID:27714757
Netazepide, a gastrin/cholecystokinin-2 receptor antagonist, can eradicate gastric neuroendocrine tumours in patients with autoimmune chronic atrophic gastritis. PMID:27704617
Chemical gastritis and colitis related to hydrogen peroxide mouthwash. PMID:27696496
Probiotics, fibre and herbal medicinal products for functional and inflammatory bowel disorders. PMID:27696378
An original pharmacoepidemiological-pharmacodynamic method: application to antipsychotic-induced movement disorders. PMID:27687785
Development of an in vivo target-engagement biomarker for TRPA1 antagonists in humans. PMID:27685892
Nutraceuticals in hypercholesterolaemia: an overview. PMID:27685833
An orally administered butyrate-releasing derivative reduces neutrophil recruitment and inflammation in dextran sulphate sodium-induced murine colitis. PMID:27684049
The variability in beta-cell function in placebo-treated subjects with type 2 diabetes: application of the weight-HbA1c-insulin-glucose (WHIG) model. PMID:27679422
Selective activation of vascular Kv 7.4/Kv 7.5 K+ channels by fasudil contributes to its vasorelaxant effect. PMID:27677924
Novel mechanism of modulation at a ligand-gated ion channel; action of 5-Cl-indole at the 5-HT3 A receptor. PMID:27677804
A multifaceted intervention to reduce drug-related complications in surgical patients. PMID:27670813
Deletion of AMPKα1 attenuates the anticontractile effect of perivascular adipose tissue (PVAT) and reduces adiponectin release. PMID:27668984
Attenuated nicotine-like effects of varenicline but not other nicotinic ACh receptor agonists in monkeys receiving nicotine daily. PMID:27667659
Functional pharmacological characterization of SER100 in cardiovascular health and disease. PMID:27667485
Utility of serum anti-cetuximab immunoglobulin E levels to identify patients at a high risk of severe hypersensitivity reaction to cetuximab. PMID:27662818
Patterns of antiplatelet drug use after a first myocardial infarction during a 10-year period. PMID:27662521
Population pharmacokinetics of paritaprevir, ombitasvir, dasabuvir, ritonavir and ribavirin in hepatitis C virus genotype 1 infection: analysis of six phase III trials. PMID:27662429
Anti-ageing active ingredients from herbs and nutraceuticals used in traditional Chinese medicine: pharmacological mechanisms and implications for drug discovery. PMID:27659301
Population pharmacokinetics of exenatide. PMID:27650681
Proanthocyanidins and hydrolysable tannins: occurrence, dietary intake and pharmacological effects. PMID:27646690
In silico prediction of chemical mechanism of action via an improved network-based inference method. PMID:27646592
Understanding how long-acting β2 -adrenoceptor agonists enhance the clinical efficacy of inhaled corticosteroids in asthma - an update. PMID:27646470
Effects of anthocyanins on the prevention and treatment of cancer. PMID:27646173
Integrating cardiomyocytes from human pluripotent stem cells in safety pharmacology: has the time come? PMID:27641943
Population pharmacokinetics and dosing recommendations for the use of deferiprone in children younger than 6 years. PMID:27641003
Absolute bioavailability and safety of a novel rivastigmine nasal spray in healthy elderly individuals. PMID:27639640
Amiloride treatment and increased risk of pressure ulcers in hospitalized patients. PMID:27639520
Continuous administration of the mTORC1 inhibitor everolimus induces tolerance and decreases autophagy in mice. PMID:27638766
Carotenoids: biochemistry, pharmacology and treatment. PMID:27638711
Branched-chain amino acids differently modulate catabolic and anabolic states in mammals: a pharmacological point of view. PMID:27638647
Smooth muscle contraction and growth of stromal cells in the human prostate are both inhibited by the Src family kinase inhibitors, AZM475271 and PP2. PMID:27638545
Curcumin, the golden nutraceutical: multitargeting for multiple chronic diseases. PMID:27638428
Selective targeting of CREB-binding protein/β-catenin inhibits growth of and extracellular matrix remodelling by airway smooth muscle. PMID:27629364
Unravelling the adiponectin paradox: novel roles of adiponectin in the regulation of cardiovascular disease. PMID:27629236
Pharmacokinetics of neratinib during coadministration with lansoprazole in healthy subjects. PMID:27628584
Proteinase activated receptor-2 counterbalances the vascular effects of endothelin-1 in fibrotic tight-skin mice. PMID:27625162
Pharmacokinetics and pharmacodynamics of PF-05190457: The first oral ghrelin receptor inverse agonist to be profiled in healthy subjects. PMID:27621150
Microtubule destabilising agents: far more than just antimitotic anticancer drugs. PMID:27620987
A review of factors explaining variability in fentanyl pharmacokinetics; focus on implications for cancer patients. PMID:27619152
Thorough QT study of the effect of intravenous amisulpride on QTc interval in Caucasian and Japanese healthy subjects. PMID:27618796
Translating QT interval prolongation from conscious dogs to humans. PMID:27614058
Smooth muscle-generated methylglyoxal impairs endothelial cell-mediated vasodilatation of cerebral microvessels in type 1 diabetic rats. PMID:27611446
Relaxin' the brain: a case for targeting the nucleus incertus network and relaxin-3/RXFP3 system in neuropsychiatric disorders. PMID:27597467
Spontaneous adverse drug reaction reports for neonates and infants in the UK 2001-2010: content and utility analysis. PMID:27597136
Adenosine A2A receptor promotes collagen type III synthesis via β-catenin activation in human dermal fibroblasts. PMID:27595240
Prevention of cardiotoxicity among survivors of childhood cancer. PMID:27591829
Vascular actions of relaxin: nitric oxide and beyond. PMID:27590257
T-cell immunity in myocardial inflammation: pathogenic role and therapeutic manipulation. PMID:27590129
Forskolin, a hedgehog signalling inhibitor, attenuates carbon tetrachloride-induced liver fibrosis in rats. PMID:27590029
Inhibition of melatonin metabolism in humans induced by chemical components from herbs and effective prediction of this risk using a computational model. PMID:27588415
Altered pharmacodynamics and pharmacokinetics of cisatracurium in patients with severe mitral valve regurgitation during anaesthetic induction period. PMID:27582302
UK medicines regulation: responding to current challenges. PMID:27580254
Clinical trials for authorized biosimilars in the European Union: a systematic review. PMID:27580073
Role of the nicotinic acetylcholine receptor α3 subtype in vascular inflammation. PMID:27572927
Potential role of bioactive peptides in prevention and treatment of chronic diseases: a narrative review. PMID:27572703
Contraindicated use of 5-alpha-reductase inhibitors in women. PMID:27567019
Poor reporting and documentation in drug-associated Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis - Lessons for medication safety. PMID:27558920
An S-warfarin and AZD1981 interaction: in vitro and clinical pilot data suggest the N-deacetylated amino acid metabolite as the primary perpetrator. PMID:27558866
Population pharmacokinetics and analgesic potency of oxycodone. PMID:27558774
An assessment of the variation in the concentration of acetylcysteine in infusions for the treatment of paracetamol overdose. PMID:27558662
Use of a cocktail probe to assess potential drug interactions with cytochrome P450 after administration of belatacept, a costimulatory immunomodulator. PMID:27552251
The novel H2 S donor 4-carboxy-phenyl isothiocyanate inhibits mast cell degranulation and renin release by decreasing intracellular calcium. PMID:27548075
High molecular weight PEGylation of human pancreatic polypeptide at position 22 improves stability and reduces food intake in mice. PMID:27545829
Cannabinoid type 1 receptor antagonism ameliorates harmaline-induced essential tremor in rat. PMID:27545646
Eosinophilic drug reactions detected by a prospective pharmacovigilance programme in a tertiary hospital. PMID:27543764
The pharmacology of palmitoylethanolamide and first data on the therapeutic efficacy of some of its new formulations. PMID:27539936
Augmented oxidative stress and preserved vasoconstriction induced by hydrogen peroxide in coronary arteries in obesity: role of COX-2. PMID:27535007
Mitochondrial uncoupler carbonyl cyanide m-chlorophenylhydrazone induces vasorelaxation without involving KATP channel activation in smooth muscle cells of arteries. PMID:27534899
Managing drug-drug interactions with new direct-acting antiviral agents in chronic hepatitis C. PMID:27530469
Comparative assessment of clinical response in patients with rheumatoid arthritis between PF-05280586, a proposed rituximab biosimilar, and rituximab. PMID:27530379
Population pharmacokinetics of intramuscular droperidol in acutely agitated patients. PMID:27530285
Edoxaban drug-drug interactions with ketoconazole, erythromycin, and cyclosporine. PMID:27530188
L-thyroxine doses required for TSH suppression in patients with differentiated thyroid cancer: Effect of a novel UGT1 marker, rs11563250A > G. PMID:27527610
Systematic review and meta-analysis of clinical outcomes of early caffeine therapy in preterm neonates. PMID:27526255
The therapeutic and diagnostic potential of the prostate specific membrane antigen/glutamate carboxypeptidase II (PSMA/GCPII) in cancer and neurological disease. PMID:27526115
Determinants of angiotensin-converting enzyme inhibitor (ACEI) intolerance and angioedema in the UK Clinical Practice Research Datalink. PMID:27524468
Does tablet formulation alone improve adherence and persistence: a comparison of ezetimibe fixed dose combination versus ezetimibe separate pill combination? PMID:27517705
Improvement of islet graft function using liraglutide is correlated with its anti-inflammatory properties. PMID:27515367
NSAID-induced symptomatic hypophosphataemia. PMID:27511443
Optimizing identification and management of COPD patients - reviewing the role of the community pharmacist. PMID:27510273
Impact of statin therapy on plasma leptin concentrations: a systematic review and meta-analysis of randomized placebo-controlled trials. PMID:27509867
Quantitative model for the blood pressure-lowering interaction of valsartan and amlodipine. PMID:27504853
Robust anti-nociceptive effects of monoacylglycerol lipase inhibition in a model of osteoarthritis pain. PMID:27501482
Comparative performance of oral midazolam clearance and plasma 4β-hydroxycholesterol to explain interindividual variability in tacrolimus clearance. PMID:27501475
Effect of fermented red ginseng on cytochrome P450 and P-glycoprotein activity in healthy subjects, as evaluated using the cocktail approach. PMID:27495955
The inhibitor of semicarbazide-sensitive amine oxidase, PXS-4728A, ameliorates key features of chronic obstructive pulmonary disease in a mouse model. PMID:27495192
A systematic review of tranexamic acid in hip fracture surgery. PMID:27492116
Azoreductases in drug metabolism. PMID:27487252
Predicting G protein-coupled receptor downstream signaling by tissue expression. PMID:27485444
Pimasertib, a selective oral MEK1/2 inhibitor: absolute bioavailability, mass balance, elimination route, and metabolite profile in cancer patients. PMID:27483391
Systematic review of published Phase 3 data on anti-PCSK9 monoclonal antibodies in patients with hypercholesterolaemia. PMID:27478094
Redox-based therapeutics in neurodegenerative disease. PMID:27477685
Integrating structural and mutagenesis data to elucidate GPCR ligand binding. PMID:27475047
Protection from interferon-β-induced neuronal apoptosis through stimulation of muscarinic acetylcholine receptors coupled to ERK1/2 activation. PMID:27474091
Effect of connexin 43 inhibition by the mimetic peptide Gap27 on corneal wound healing, inflammation and neovascularization. PMID:27472295
Butein provides neuroprotective and anti-neuroinflammatory effects through Nrf2/ARE-dependent haem oxygenase 1 expression by activating the PI3K/Akt pathway. PMID:27465039
The effect of imiquimod on taste bud calcium transients and transmitter secretion. PMID:27464850
Anti-inflammatory and analgesic activity of carnosol and carnosic acid in vivo and in vitro and in silico analysis of their target interactions. PMID:27464306
The anti-inflammatory effects of PGE2 on human lung macrophages are mediated by the EP4 receptor. PMID:27460634
Activation and modulation of recombinant glycine and GABAA receptors by 4-halogenated analogues of propofol. PMID:27459129
Getting the most out of PubChem for virtual screening. PMID:27454129
Application of the integrated glucose-insulin model for cross-study characterization of T2DM patients on metformin background treatment. PMID:27450071
The novel late Na+ current inhibitor, GS-6615 (eleclazine) and its anti-arrhythmic effects in rabbit isolated heart preparations. PMID:27449698
Therapeutic potential of adipose stem cell-derived conditioned medium against pulmonary hypertension and lung fibrosis. PMID:27448286
Quantitative pharmacokinetic-pharmacodynamic modelling of baclofen-mediated cardiovascular effects using BP and heart rate in rats. PMID:27448216
Effect of long-term adherence to clopidogrel on the VASP-PRI after elective coronary stent implantation: a randomized controlled study. PMID:27447737
Population pharmacokinetics of doxorubicin and doxorubicinol in patients diagnosed with non-Hodgkin's lymphoma. PMID:27447545
Structural commonality of C1q TNF-related proteins and their potential to activate relaxin/insulin-like family peptide receptor 1 signalling pathways in cancer cells. PMID:27443788
Involvement of endocannabinoid neurotransmission in the bed nucleus of stria terminalis in cardiovascular responses to acute restraint stress in rats. PMID:27441413
Sarcolemmal dependence of cardiac protection and stress-resistance: roles in aged or diseased hearts. PMID:27439627
Glucagon-like peptide-1 receptor signalling reduces microvascular thrombosis, nitro-oxidative stress and platelet activation in endotoxaemic mice. PMID:27435156
Oral supplementation with L-homoarginine in young volunteers. PMID:27434056
The sphingosine-1-phosphate analogue, FTY-720, promotes the proliferation of embryonic neural stem cells, enhances hippocampal neurogenesis and learning and memory abilities in adult mice. PMID:27429358
Pharmacokinetic-pharmacodynamic modelling of drug-induced QTc interval prolongation in man: prediction from in vitro human ether-à-go-go-related gene binding and functional inhibition assays and conscious dog studies. PMID:27427789
The 5A apolipoprotein A-I (apoA-I) mimetic peptide ameliorates experimental colitis by regulating monocyte infiltration. PMID:27425846
The oxidative stress theory of disease: levels of evidence and epistemological aspects. PMID:27425643
Antagonism of the proinflammatory and pronociceptive actions of canonical and biased agonists of protease-activated receptor-2. PMID:27423137
Tumour-selective targeting of drug metabolizing enzymes to treat metastatic cancer. PMID:27423046
Epithelial propionyl- and butyrylcholine as novel regulators of colonic ion transport. PMID:27423041
Inhibition of spleen tyrosine kinase attenuates IgE-mediated airway contraction and mediator release in human precision cut lung slices. PMID:27417329
Pharmacokinetics of oral fludrocortisone in septic shock. PMID:27416887
Delays during the administration of acetylcysteine for the treatment of paracetamol overdose. PMID:27412926
Blood pressure-lowering effects of sulodexide depend on albuminuria severity: post hoc analysis of the sulodexide microalbuminuria and macroalbuminuria studies. PMID:27412828
Effects of a novel potent melanin-concentrating hormone receptor 1 antagonist, AZD1979, on body weight homeostasis in mice and dogs. PMID:27400775
Phase I metabolites of mephedrone display biological activity as substrates at monoamine transporters. PMID:27391165
Anti-angiogenic effects of novel cyclin-dependent kinase inhibitors with a pyrazolo[4,3-d]pyrimidine scaffold. PMID:27390037
Inhibition of PI3K promotes dilation of human small airways in a rho kinase-dependent manner. PMID:27352269
Antitumour and antiangiogenic activities of [Pt(O,O'-acac)(γ-acac)(DMS)] in a xenograft model of human renal cell carcinoma. PMID:27351124
A novel plasminogen activator inhibitor-1 inhibitor, TM5441, protects against high-fat diet-induced obesity and adipocyte injury in mice. PMID:27339909
Magel2-null mice are hyper-responsive to setmelanotide, a melanocortin 4 receptor agonist. PMID:27339818
Genetic fusion of human FGF21 to a synthetic polypeptide improves pharmacokinetics and pharmacodynamics in a mouse model of obesity. PMID:27339749
The receptor for advanced glycation end products is required for β-catenin stabilization in a chemical-induced asthma model. PMID:27332707
Direct modulation of TRPM4 and TRPM3 channels by the phospholipase C inhibitor U73122. PMID:27328745
Role of OCT2 and MATE1 in renal disposition and toxicity of nitidine chloride. PMID:27324234
Update on melatonin receptors: IUPHAR Review 20. PMID:27314810
IDAAPM: integrated database of ADMET and adverse effects of predictive modeling based on FDA approved drug data. PMID:27303447
Epidermal growth factor is a critical regulator of the cytokine IL-33 in intestinal epithelial cells. PMID:27300306
Literature information in PubChem: associations between PubChem records and scientific articles. PMID:27293485
Opioid and cannabinoid synergy in a mouse neuropathic pain model. PMID:27278681
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Anti-fibrotic actions of relaxin. PMID:27250825
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The α7 nicotinic receptor dual allosteric agonist and positive allosteric modulator GAT107 reverses nociception in mouse models of inflammatory and neuropathic pain. PMID:27243753
Signal transduction pathways activated by insulin-like peptide 5 at the relaxin family peptide RXFP4 receptor. PMID:27243554
The actions of relaxin on the human cardiovascular system. PMID:27239943
Effects of xanthine oxidase inhibition with febuxostat on the development of nephropathy in experimental type 2 diabetes. PMID:27238746
Nalmefene is effective at reducing alcohol seeking, treating alcohol-cocaine interactions and reducing alcohol-induced histone deacetylases gene expression in blood. PMID:27238566
In permanent atrial fibrillation, PDE3 reduces force responses to 5-HT, but PDE3 and PDE4 do not cause the blunting of atrial arrhythmias. PMID:27238373
Pharmacological profile of Ascaris suum ACR-16, a new homomeric nicotinic acetylcholine receptor widely distributed in Ascaris tissues. PMID:27238203
Effect of flecainide derivatives on sarcoplasmic reticulum calcium release suggests a lack of direct action on the cardiac ryanodine receptor. PMID:27237957
Research Resources for Nuclear Receptor Signaling Pathways. PMID:27216565
Key role of heat shock protein 90 in leptin-induced STAT3 activation and feeding regulation. PMID:27205876
TRPA1 activation leads to neurogenic vasodilatation: involvement of reactive oxygen nitrogen species in addition to CGRP and NO. PMID:27189253
Mitochondrial dysfunction in inflammatory responses and cellular senescence: pathogenesis and pharmacological targets for chronic lung diseases. PMID:27189175
Targeting vascular (endothelial) dysfunction. PMID:27187006
Ginkgolide K protects the heart against endoplasmic reticulum stress injury by activating the inositol-requiring enzyme 1α/X box-binding protein-1 pathway. PMID:27186946
Neutrophil maturation rate determines the effects of dipeptidyl peptidase 1 inhibition on neutrophil serine protease activity. PMID:27186823
Capsaicin induces browning of white adipose tissue and counters obesity by activating TRPV1 channel-dependent mechanisms. PMID:27174467
Hepatic NAD(+) deficiency as a therapeutic target for non-alcoholic fatty liver disease in ageing. PMID:27174364
Novel relaxant effects of RPL554 on guinea pig tracheal smooth muscle contractility. PMID:27174172
Nitric oxide generation by the organic nitrate NDBP attenuates oxidative stress and angiotensin II-mediated hypertension. PMID:27160064
Preclinical studies of VS-505: a non-absorbable highly effective phosphate binder. PMID:27156057
GPCRdb: the G protein-coupled receptor database - an introduction. PMID:27155948
Functional modulation of glycine receptors by the alkaloid gelsemine. PMID:27128379
Mitogen-inducible gene-6 partly mediates the inhibitory effects of prenatal dexamethasone exposure on endochondral ossification in long bones of fetal rats. PMID:27128203
Extracellular nicotinamide phosphoribosyltransferase, a new cancer metabokine. PMID:27128025
Antagonizing midkine accelerates fracture healing in mice by enhanced bone formation in the fracture callus. PMID:27111560
Obestatin as a key regulator of metabolism and cardiovascular function with emerging therapeutic potential for diabetes. PMID:27111465
F16357, a novel protease-activated receptor 1 antagonist, improves urodynamic parameters in a rat model of interstitial cystitis. PMID:27111354
Targeting the NO/superoxide ratio in adipose tissue: relevance to obesity and diabetes management. PMID:27079449
A novel transgenic rabbit model with reduced repolarization reserve: long QT syndrome caused by a dominant-negative mutation of the KCNE1 gene. PMID:27076034
Wikidata as a semantic framework for the Gene Wiki initiative. PMID:26989148
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730 articles citing: The IUPHAR/BPS Guide to PHARMACOLOGY: an expert-driven knowledgebase of drug targets and their ligands

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Mapping the function of neuronal ion channels in model and experiment. PMID:28267430
Competitive association binding kinetic assays: a new tool to detect two different binding orientations of a ligand to its target protein under distinct conditions? PMID:28220211
An inhaled dose of budesonide induces genes involved in transcription and signaling in the human airways: enhancement of anti- and proinflammatory effector genes. PMID:28116096
Toward the next step in G protein-coupled receptor research: a knowledge-driven analysis for the next potential targets in drug discovery. PMID:28063110
A comprehensive map of molecular drug targets. PMID:27910877
Size distribution of function-based human gene sets and the split-merge model. PMID:27853602
In silico prediction of chemical mechanism of action via an improved network-based inference method. PMID:27646592
Glucagon-Like Peptide-1 and Its Class B G Protein-Coupled Receptors: A Long March to Therapeutic Successes. PMID:27630114
A Cell-type-resolved Liver Proteome. PMID:27562671
Prediction of compound-target interactions of natural products using large-scale drug and protein information. PMID:27490208
BCL11A Haploinsufficiency Causes an Intellectual Disability Syndrome and Dysregulates Transcription. PMID:27453576
The harmonizome: a collection of processed datasets gathered to serve and mine knowledge about genes and proteins. PMID:27374120
Targeting orphan G protein-coupled receptors for the treatment of diabetes and its complications: C-peptide and GPR146. PMID:27306986
Cogena, a novel tool for co-expressed gene-set enrichment analysis, applied to drug repositioning and drug mode of action discovery. PMID:27234029
Hypoglycemia unawareness prevention: Targeting glucagon production. PMID:27080082
An update on PPAR activation by cannabinoids. PMID:27077495
Amylin structure-function relationships and receptor pharmacology: implications for amylin mimetic drug development. PMID:27061187
Inhibition of fatty acid synthase is protective in pulmonary hypertension. PMID:27061087
Combining an epithelial repair factor and anti-fibrotic with a corticosteroid offers optimal treatment for allergic airways disease. PMID:27060978
Structural Determinants of Binding the Seven-transmembrane Domain of the Glucagon-like Peptide-1 Receptor (GLP-1R). PMID:27059958
Interplay between the kinin B1 receptor and inducible nitric oxide synthase in insulin resistance. PMID:27059924
Relaxin and insulin-like peptide 3 in the musculoskeletal system: from bench to bedside. PMID:27059798
The role of metformin and resveratrol in the prevention of hypoxia-inducible factor 1α accumulation and fibrosis in hypoxic adipose tissue. PMID:27059094
Antioxidant effects of resveratrol in the cardiovascular system. PMID:27058985
Topology based identification and comprehensive classification of four-transmembrane helix containing proteins (4TMs) in the human genome. PMID:27030248
A genomic case study of mixed fibrolamellar hepatocellular carcinoma. PMID:27029710
The novel nonapeptide acein targets angiotensin converting enzyme in the brain and induces dopamine release. PMID:27027724
BN-9, a chimeric peptide with mixed opioid and neuropeptide FF receptor agonistic properties, produces nontolerance-forming antinociception in mice. PMID:27018797
Novel application assigned to toluquinol: inhibition of lymphangiogenesis by interfering with VEGF-C/VEGFR-3 signalling pathway. PMID:27018653
Intersubunit interactions at putative sites of ethanol action in the M3 and M4 domains of the NMDA receptor GluN1 and GluN2B subunits. PMID:27010645
Possible role for anisodamine in organophosphate poisoning. PMID:27010563
Apelin-13 administration protects against ischaemia/reperfusion-mediated apoptosis through the FoxO1 pathway in high-fat diet-induced obesity. PMID:27005319
Alterations in pharmacological and behavioural responses in recombinant mouse line with an increased predisposition to catalepsy: role of the 5-HT1A receptor. PMID:27004983
Effects of glucagon-like peptide-1 on the differentiation and metabolism of human adipocytes. PMID:26993859
Present and future pharmacotherapeutic agents in heart failure: an evolving paradigm. PMID:26993743
A novel protein tyrosine phosphatase 1B inhibitor with therapeutic potential for insulin resistance. PMID:26990621
5-HT3 receptors promote colonic inflammation via activation of substance P/neurokinin-1 receptors in dextran sulphate sodium-induced murine colitis. PMID:26990520
Preventive and chronic mineralocorticoid receptor antagonism is highly beneficial in obese SHHF rats. PMID:26990406
New aspects of p66Shc in ischaemia reperfusion injury and other cardiovascular diseases. PMID:26990284
Identification of a selective glucocorticoid receptor modulator that prevents both diet-induced obesity and inflammation. PMID:26990179
Ozanimod (RPC1063) is a potent sphingosine-1-phosphate receptor-1 (S1P1 ) and receptor-5 (S1P5 ) agonist with autoimmune disease-modifying activity. PMID:26990079
The tyrosine kinase inhibitor dasatinib reduces lung inflammation and remodelling in experimental allergic asthma. PMID:26989986
Endothelin. PMID:26956245
PnPP-19, a spider toxin peptide, induces peripheral antinociception through opioid and cannabinoid receptors and inhibition of neutral endopeptidase. PMID:26947933
Harnessing publicly available genetic data to prioritize lipid modifying therapeutic targets for prevention of coronary heart disease based on dysglycemic risk. PMID:26946290
The G-protein biased partial κ opioid receptor agonist 6'-GNTI blocks hippocampal paroxysmal discharges without inducing aversion. PMID:26928671
The pharmacodynamics, safety and pharmacokinetics of single doses of the motilin agonist, camicinal, in type 1 diabetes mellitus with slow gastric emptying. PMID:26924243
Translational mixed-effects PKPD modelling of recombinant human growth hormone - from hypophysectomized rat to patients. PMID:26921845
The pregnane X receptor down-regulates organic cation transporter 1 (SLC22A1) in human hepatocytes by competing for ("squelching") SRC-1 coactivator. PMID:26920453
Posttranscriptional regulation of FOXO expression: microRNAs and beyond. PMID:26920226
Antinociceptive effects of sinomenine in a rat model of postoperative pain. PMID:26915970
Diacylglycerol lipase β inhibition reverses nociceptive behaviour in mouse models of inflammatory and neuropathic pain. PMID:26915789
Drp-1, a potential therapeutic target for brain ischaemic stroke. PMID:26915692
Endothelin-1 shifts the mediator of bradykinin-induced relaxation from NO to H2 O2 in resistance arteries from patients with cardiovascular disease. PMID:26914408
Berberine improves mesenteric artery insulin sensitivity through up-regulating insulin receptor-mediated signalling in diabetic rats. PMID:26914282
Aristolochic acid, a plant extract used in the treatment of pain and linked to Balkan endemic nephropathy, is a regulator of K2P channels. PMID:26914156
Adrenaline: insights into its metabolic roles in hypoglycaemia and diabetes. PMID:26896587
Intranasal exposure to monoclonal antibody Fab fragments to Japanese cedar pollen Cry j1 suppresses Japanese cedar pollen-induced allergic rhinitis. PMID:26895546
Therapeutic time window for angiotensin-(1-7) in acute lung injury. PMID:26895462
New use for an old drug: COX-independent anti-inflammatory effects of sulindac in models of cystic fibrosis. PMID:26894321
The brain renin-angiotensin system plays a crucial role in regulating body weight in diet-induced obesity in rats. PMID:26892671
Identification of sirtuin 1 as a promising therapeutic target for hypertrophic scars. PMID:26891034
D-Penicillamine modulates hydrogen sulfide (H2S) pathway through selective inhibition of cystathionine-γ-lyase. PMID:26890936
Digoxin reduces atherosclerosis in apolipoprotein E-deficient mice. PMID:26879387
ChemProt-3.0: a global chemical biology diseases mapping. PMID:26876982
Role of COX-2-derived PGE2 on vascular stiffness and function in hypertension. PMID:26856544
Inflammation: maladies, models, mechanisms and molecules. PMID:26847725
Protection against cardiac hypertrophy by geniposide involves the GLP-1 receptor / AMPKα signalling pathway. PMID:26845648
Pancreatic polypeptide and its central Y4 receptors are essential for cued fear extinction and permanent suppression of fear. PMID:26844810
Protease-activated receptor 4: from structure to function and back again. PMID:26844674
Trimetazidine does not alter metabolic substrate oxidation in cardiac mitochondria of target patient population. PMID:26844527
A review of the new HGNC gene family resource. PMID:26842383
Identifying ligands at orphan GPCRs: current status using structure-based approaches. PMID:26837045
Immunotherapy of cancer: from monoclonal to oligoclonal cocktails of anti-cancer antibodies: IUPHAR Review 18. PMID:26833433
Dynamics of Phosphoinositide-Dependent Signaling in Sympathetic Neurons. PMID:26818524
On the different experimental manifestations of two-state 'induced-fit' binding of drugs to their cellular targets. PMID:26808227
The acute and long-term L-DOPA effects are independent from changes in the activity of dorsal raphe serotonergic neurons in 6-OHDA lesioned rats. PMID:26805402
Identification of A3 adenosine receptor agonists as novel non-narcotic analgesics. PMID:26804983
Molecular and functional characterization of Kv 7 channels in penile arteries and corpus cavernosum of healthy and metabolic syndrome rats. PMID:26802314
Involvement of the orexin/hypocretin system in the pharmacological effects induced by Δ(9) -tetrahydrocannabinol. PMID:26799708
Presynaptic, release-regulating mGlu2 -preferring and mGlu3 -preferring autoreceptors in CNS: pharmacological profiles and functional roles in demyelinating disease. PMID:26791341
Biased ligand quantification in drug discovery: from theory to high throughput screening to identify new biased μ opioid receptor agonists. PMID:26791140
Fenofibrate inhibits atrial metabolic remodelling in atrial fibrillation through PPAR-α/sirtuin 1/PGC-1α pathway. PMID:26787506
Pharmacological characterization of the first in class clinical candidate PF-05190457: a selective ghrelin receptor competitive antagonist with inverse agonism that increases vagal afferent firing and glucose-dependent insulin secretion ex vivo. PMID:26784385
The metabotropic glutamate 5 receptor is necessary for extinction of cocaine-associated cues. PMID:26784278
Detecting moxifloxacin-induced QTc prolongation in thorough QT and early clinical phase studies using a highly automated ECG analysis approach. PMID:26784016
Effects of the imidazoline I2 receptor agonist 2-BFI on the development of tolerance to and behavioural/physical dependence on morphine in rats. PMID:26776953
Daily morphine administration increases impulsivity in rats responding under a 5-choice serial reaction time task. PMID:26776751
Effects of new-generation inhibitors of the calcium-activated chloride channel anoctamin 1 on slow waves in the gastrointestinal tract. PMID:26774021
Safety, pharmacokinetics and pharmacodynamics of the anti-hepcidin Spiegelmer lexaptepid pegol in healthy subjects. PMID:26773325
Hippocampal 5-HT7 receptors signal phosphorylation of the GluA1 subunit to facilitate AMPA receptor mediated-neurotransmission in vitro and in vivo. PMID:26773257
Effects of P2Y12 receptor antagonists beyond platelet inhibition--comparison of ticagrelor with thienopyridines. PMID:26758983
ROS in gastrointestinal inflammation: Rescue Or Sabotage? PMID:26758851
Gender-related differential effect of tachykinin NK2 receptor-mediated visceral hyperalgesia in guinea pig colon. PMID:26758701
Eact, a small molecule activator of TMEM16A, activates TRPV1 and elicits pain- and itch-related behaviours. PMID:26756551
Nociceptin/orphanin FQ (N/OFQ) modulates immunopathology and airway hyperresponsiveness representing a novel target for the treatment of asthma. PMID:26756419
Microglia antioxidant systems and redox signalling. PMID:26754582
Single administration of recombinant IL-6 restores the gene expression of lipogenic enzymes in liver of fasting IL-6-deficient mice. PMID:26750868
The Warburg effect and drug resistance. PMID:26750865
α1B -Adrenoceptor signalling regulates bone formation through the up-regulation of CCAAT/enhancer-binding protein δ expression in osteoblasts. PMID:26750808
Anti-oxidative effect of AST-120 on kidney injury after myocardial infarction. PMID:26750807
NADPH oxidases in oxidant production by microglia: activating receptors, pharmacology and association with disease. PMID:26750203
Madecassoside ameliorates bleomycin-induced pulmonary fibrosis in mice through promoting the generation of hepatocyte growth factor via PPAR-γ in colon. PMID:26750154
Contribution of adrenomedullin to the switch of G protein-coupled μ-opioid receptors from Gi to Gs in the spinal dorsal horn following chronic morphine exposure in rats. PMID:26750148
Involvement of Rac1 signalling pathway in the development and maintenance of acute inflammatory pain induced by bee venom injection. PMID:26700000
Structure-activity relationship studies of citalopram derivatives: examining substituents conferring selectivity for the allosteric site in the 5-HT transporter. PMID:26699847
Induction of endothelium-dependent constriction of mesenteric arteries in endotoxemic hypotensive shock. PMID:26694894
Predictive Modeling of Drug Treatment in the Area of Personalized Medicine. PMID:26692759
Compound 9a, a novel synthetic histone deacetylase inhibitor, protects against septic injury in mice by suppressing MAPK signalling. PMID:26689981
Differences in asthma study models and the effectiveness of β2 -adrenoceptor ligands: response to Lipworth et al. PMID:26687674
From mouse to man: predicting biased effects of beta-blockers in asthma. PMID:26687673
Possible pharmacotherapy for nifedipine-induced gingival overgrowth: 18α-glycyrrhetinic acid inhibits human gingival fibroblast growth. PMID:26676684
Bidirectional crosstalk via IL-6, PGE2 and PGD2 between murine myofibroblasts and alternatively activated macrophages enhances anti-inflammatory phenotype in both cells. PMID:26676587
Decursin enhances TRAIL-induced apoptosis through oxidative stress mediated- endoplasmic reticulum stress signalling in non-small cell lung cancers. PMID:26661339
Galanin inhibits GLP-1 and GIP secretion via the GAL1 receptor in enteroendocrine L and K cells. PMID:26661062
Endothelin-1 suppresses insulin-stimulated Akt phosphorylation and glucose uptake via GPCR kinase 2 in skeletal muscle cells. PMID:26660861
Time-dependent activation of prostacyclin and nitric oxide pathways during continuous i.v. infusion of serelaxin (recombinant human H2 relaxin). PMID:26660642
Distinct and complementary roles for α and β isoenzymes of PKC in mediating vasoconstrictor responses to acutely elevated glucose. PMID:26660275
Genipin alleviates sepsis-induced liver injury by restoring autophagy. PMID:26660048
Changes in Membrane Receptors and Ion Channels as Potential Biomarkers for Osteoarthritis. PMID:26648874
Role of EP2 and EP4 receptors in airway microvascular leak induced by prostaglandin E2. PMID:26639895
Chinese innovation in cardiovascular drug discovery. PMID:26629875
Integrating the GPCR transactivation-dependent and biased signalling paradigms in the context of PAR1 signalling. PMID:26624252
Monoclonal antibodies: the new magic bullets for allergy: IUPHAR Review 17. PMID:26620589
NVP-TAE684 reverses multidrug resistance (MDR) in human osteosarcoma by inhibiting P-glycoprotein (PGP1) function. PMID:26603906
Pharmacological characterization of the opioid inactive isomers (+)-naltrexone and (+)-naloxone as antagonists of toll-like receptor 4. PMID:26603732
Involvement of transglutaminase 2 and voltage-gated potassium channels in cystamine vasodilatation in rat mesenteric small arteries. PMID:26603619
What is the evidence for the role of TRP channels in inflammatory and immune cells? PMID:26603538
The high frequency relationship: implications for torsadogenic hERG blockers. PMID:26589499
Molecular mechanism of positive allosteric modulation of the metabotropic glutamate receptor 2 by JNJ-46281222. PMID:26589404
Therapeutic target database update 2016: enriched resource for bench to clinical drug target and targeted pathway information. PMID:26578601
N-terminally and C-terminally truncated forms of glucose-dependent insulinotropic polypeptide are high-affinity competitive antagonists of the human GIP receptor. PMID:26572091
Trimetazidine prevents macrophage-mediated septic myocardial dysfunction via activation of the histone deacetylase sirtuin 1. PMID:26566260
APT070 (mirococept), a membrane-localizing C3 convertase inhibitor, attenuates early human islet allograft damage in vitro and in vivo in a humanized mouse model. PMID:26565566
Natural and synthetic flavonoid modulation of TRPC5 channels. PMID:26565375
Threonine532 phosphorylation in ClC-3 channels is required for angiotensin II-induced Cl(-) current and migration in cultured vascular smooth muscle cells. PMID:26562480
A novel approach to inhibit bone resorption: exosite inhibitors against cathepsin K. PMID:26562357
Optical probes based on G protein-coupled receptors - added work or added value? PMID:26562218
Mechanism of allosteric activation of TMEM16A/ANO1 channels by a commonly used chloride channel blocker. PMID:26562072
Endothelin-1 contributes to the progression of renal injury in sickle cell disease via reactive oxygen species. PMID:26561980
DGIdb 2.0: mining clinically relevant drug-gene interactions. PMID:26531824
Twenty years of the MEROPS database of proteolytic enzymes, their substrates and inhibitors. PMID:26527717
PPARγ agonists regulate bidirectional transport of amyloid-β across the blood-brain barrier and hippocampus plasticity in db/db mice. PMID:26507867
All-trans retinoic acid protects against doxorubicin-induced cardiotoxicity by activating the ERK2 signalling pathway. PMID:26507774
Blood-brain and retinal barriers show dissimilar ABC transporter impacts and concealed effect of P-glycoprotein on a novel verapamil influx carrier. PMID:26507673
β-Arrestin 2 dependence of δ opioid receptor agonists is correlated with alcohol intake. PMID:26507558
Honokiol sensitizes breast cancer cells to TNF-α induction of apoptosis by inhibiting Nur77 expression. PMID:26505879
Prostaglandin E2 inhibits neutrophil extracellular trap formation through production of cyclic AMP. PMID:26505736
Cannabidiol protects an in vitro model of the blood-brain barrier from oxygen-glucose deprivation via PPARγ and 5-HT1A receptors. PMID:26497782
CREB, AP-1, ternary complex factors and MAP kinases connect transient receptor potential melastatin-3 (TRPM3) channel stimulation with increased c-Fos expression. PMID:26493679
Enhanced serelaxin signalling in co-cultures of human primary endothelial and smooth muscle cells. PMID:26493539
Bcl-2 phosphorylation confers resistance on chronic lymphocytic leukaemia cells to the BH3 mimetics ABT-737, ABT-263 and ABT-199 by impeding direct binding. PMID:26493374
Functional, electrophysiological and molecular docking analysis of the modulation of Cav 1.2 channels in rat vascular myocytes by murrayafoline A. PMID:26493241
Mirabegron relaxes urethral smooth muscle by a dual mechanism involving β3 -adrenoceptor activation and α1 -adrenoceptor blockade. PMID:26493129
Activity of botulinum toxin type A in cranial dura: implications for treatment of migraine and other headaches. PMID:26493010
Low free drug concentration prevents inhibition of F508del CFTR functional expression by the potentiator VX-770 (ivacaftor). PMID:26492939
Platelet secretion of CXCL4 is Rac1-dependent and regulates neutrophil infiltration and tissue damage in septic lung damage. PMID:26478565
Inhibition of the regulator of G protein signalling RGS4 in the spinal cord decreases neuropathic hyperalgesia and restores cannabinoid CB1 receptor signalling. PMID:26478461
Hydrogen peroxide activates store-operated Ca(2+) entry in coronary arteries. PMID:26478127
High-fat diet-induced metabolic disorders impairs 5-HT function and anxiety-like behavior in mice. PMID:26472268
The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. PMID:26464438
Microglial activation and progressive brain changes in schizophrenia. PMID:26455353
Knockdown of the small conductance Ca(2+) -activated K(+) channels is potently cytotoxic in breast cancer cell lines. PMID:26454020
Nicergoline inhibits human platelet Ca(2+) signalling through triggering a microtubule-dependent reorganization of the platelet ultrastructure. PMID:26450366
Homoharringtonine binds to and increases myosin-9 in myeloid leukaemia. PMID:26448459
Mechanisms by which the thiazolidinedione troglitazone protects against sucrose-induced hepatic fat accumulation and hyperinsulinaemia. PMID:26447327
Resveratrol exerts a biphasic effect on apolipoprotein M. PMID:26445217
Identification of a resveratrol tetramer as a potent inhibitor of hepatitis C virus helicase. PMID:26445091
The proton-coupled oligopeptide transporter 1 plays a major role in the intestinal permeability and absorption of 5-aminolevulinic acid. PMID:26444978
Quetiapine and its metabolite norquetiapine: translation from in vitro pharmacology to in vivo efficacy in rodent models. PMID:26436896
GPR55 promotes migration and adhesion of colon cancer cells indicating a role in metastasis. PMID:26436760
Molecular switches under TGFβ signalling during progression from cardiac hypertrophy to heart failure. PMID:26431212
Adenosine A1 receptor activation attenuates cardiac hypertrophy and fibrosis in response to α1 -adrenoceptor stimulation in vivo. PMID:26406609
Integration of reward signalling and appetite regulating peptide systems in the control of food-cue responses. PMID:26403657
Characterization of 12 GnRH peptide agonists - a kinetic perspective. PMID:26398856
Identification of N-arachidonoyl dopamine as a highly biased ligand at cannabinoid CB1 receptors. PMID:26398720
High avidity chimeric monoclonal antibodies against the extracellular domains of human aquaporin-4 competing with the neuromyelitis optica autoantibody, NMO-IgG. PMID:26398585
The novel, orally available and peripherally restricted selective cannabinoid CB2 receptor agonist LEI-101 prevents cisplatin-induced nephrotoxicity. PMID:26398481
Actions of the dual FAAH/MAGL inhibitor JZL195 in a murine neuropathic pain model. PMID:26398331
Loss of 5-lipoxygenase activity protects mice against paracetamol-induced liver toxicity. PMID:26398229
Neural correlates of interactions between cannabidiol and Δ(9) -tetrahydrocannabinol in mice: implications for medical cannabis. PMID:26377899
Contractile function assessment by intraventricular balloon alters the ability of regional ischaemia to evoke ventricular fibrillation. PMID:26377788
Prostaglandin E2 and the EP receptors in malignancy: possible therapeutic targets? PMID:26377664
Ceftriaxone attenuates acute cocaine-evoked dopaminergic neurotransmission in the nucleus accumbens of the rat. PMID:26375494
Identification of the putative binding pocket of valerenic acid on GABAA receptors using docking studies and site-directed mutagenesis. PMID:26375408
Protective effect of the multitarget compound DPH-4 on human SSAO/VAP-1-expressing hCMEC/D3 cells under oxygen-glucose deprivation conditions: an in vitro experimental model of cerebral ischaemia. PMID:26362823
Medial prefrontal cortex TRPV1 channels modulate the baroreflex cardiac activity in rats. PMID:26360139
Mevastatin ameliorates sphingosine 1-phosphate-induced COX-2/PGE2-dependent cell migration via FoxO1 and CREB phosphorylation and translocation. PMID:26359950
Species-specific action of (Pro3)GIP - a full agonist at human GIP receptors, but a partial agonist and competitive antagonist at rat and mouse GIP receptors. PMID:26359804
Valproic acid protects against haemorrhagic shock-induced signalling changes via PPARγ activation in an in vitro model. PMID:26333042
High-density lipoprotein inhibits human M1 macrophage polarization through redistribution of caveolin-1. PMID:26332942
Neuroprotective effects of multifaceted hybrid agents targeting MAO, cholinesterase, iron and β-amyloid in ageing and Alzheimer's disease. PMID:26332830
Fasting protects against the side effects of irinotecan treatment but does not affect anti-tumour activity in mice. PMID:26332723
Cell type-specific transcriptomics of hypothalamic energy-sensing neuron responses to weight-loss. PMID:26329458
Fluorescence- and bioluminescence-based approaches to study GPCR ligand binding. PMID:26317175
Divergent modulation of Rho-kinase and Ca(2+) influx pathways by Src family kinases and focal adhesion kinase in airway smooth muscle. PMID:26294392
Role of endothelial TRPV4 channels in vascular actions of the endocannabinoid, 2-arachidonoylglycerol. PMID:26294342
Salsalate attenuates diet induced non-alcoholic steatohepatitis in mice by decreasing lipogenic and inflammatory processes. PMID:26292849
Putative binding sites for arachidonic acid on the human cardiac Kv 1.5 channel. PMID:26292661
Early treatment with atorvastatin exerts parenchymal and vascular protective effects in experimental cerebral ischaemia. PMID:26289767
Crucial role of the orexin-B C-terminus in the induction of OX1 receptor-mediated apoptosis: analysis by alanine scanning, molecular modelling and site-directed mutagenesis. PMID:26282891
The sGC stimulator riociguat inhibits platelet function in washed platelets but not in whole blood. PMID:26282717
Chronic intermittent toluene inhalation in adolescent rats results in metabolic dysfunction with altered glucose homeostasis. PMID:26282596
Human induced pluripotent stem cell-derived versus adult cardiomyocytes: an in silico electrophysiological study on effects of ionic current block. PMID:26276951
Metabotropic glutamate receptor subtype 5: molecular pharmacology, allosteric modulation and stimulus bias. PMID:26276909
State-dependent blocking mechanism of Kv 1.3 channels by the antimycobacterial drug clofazimine. PMID:26276903
High glucose-induced changes in hyaloid-retinal vessels during early ocular development of zebrafish: a short-term animal model of diabetic retinopathy. PMID:26276677
Superagonism at G protein-coupled receptors and beyond. PMID:26276510
Pro-cognitive activity in rats of 3-furan-2-yl-N-p-tolyl-acrylamide, a positive allosteric modulator of the α7 nicotinic acetylcholine receptor. PMID:26276349
Actions of KMUP-1, a xanthine and piperazine derivative, on voltage-gated Na(+) and Ca(2+) -activated K(+) currents in GH3 pituitary tumour cells. PMID:26276211
Neurokinin 1 receptor blockade in the medial amygdala attenuates alcohol drinking in rats with innate anxiety but not in Wistar rats. PMID:26275374
Dipeptidyl peptidase 4 promotes epithelial cell transformation and breast tumourigenesis via induction of PIN1 gene expression. PMID:26267432
Hypersensitivity to intravenous iron: classification, terminology, mechanisms and management. PMID:26265306
Different downstream signalling of CCK1 receptors regulates distinct functions of CCK in pancreatic beta cells. PMID:26248680
Molecular dynamics and functional studies define a hot spot of crystal contacts essential for PcTx1 inhibition of acid-sensing ion channel 1a. PMID:26248594
Cinnamaldehyde inhibits inflammation and brain damage in a mouse model of permanent cerebral ischaemia. PMID:26234631
Macrolides increase the expression of 11β-hydroxysteroid dehydrogenase 1 in human sinonasal epithelium, contributing to glucocorticoid activation in sinonasal mucosa. PMID:26228509
Propranolol decreases retention of fear memory by modulating the stability of surface glutamate receptor GluA1 subunits in the lateral amygdala. PMID:26228348
Combining citrulline with atorvastatin preserves glucose homeostasis in a murine model of diet-induced obesity. PMID:26228176
Alcohol enhances the psychostimulant and conditioning effects of mephedrone in adolescent mice; postulation of unique roles of D3 receptors and BDNF in place preference acquisition. PMID:26228024
Angiotensin II stimulation alters vasomotor response to adenosine in mouse mesenteric artery: role for A1 and A2B adenosine receptors. PMID:26227882
Protective effect of exogenous nitrite in postoperative ileus. PMID:26227770
A novel multi-parameter assay to dissect the pharmacological effects of different modes of integrin αLβ2 inhibition in whole blood. PMID:26224111
Alkaline phosphatase protects against renal inflammation through dephosphorylation of lipopolysaccharide and adenosine triphosphate. PMID:26222228
α7 nicotinic ACh receptor-deficient mice exhibit sustained attention impairments that are reversed by β2 nicotinic ACh receptor activation. PMID:26222090
Addition of a single methyl group to a small molecule sodium channel inhibitor introduces a new mode of gating modulation. PMID:26220736
Pharmacophore-based discovery of inhibitors of a novel drug/proton antiporter in human brain endothelial hCMEC/D3 cell line. PMID:26220580
Salvage of nicotinamide adenine dinucleotide plays a critical role in the bioenergetic recovery of post-hypoxic cardiomyocytes. PMID:26218637
Continuous inhibition of 11β-hydroxysteroid dehydrogenase type I in adipose tissue leads to tachyphylaxis in humans and rats but not in mice. PMID:26218540
Cannabidiol is a negative allosteric modulator of the cannabinoid CB1 receptor. PMID:26218440
Simulating the influence of plasma protein on measured receptor affinity in biochemical assays reveals the utility of Schild analysis for estimating compound affinity for plasma proteins. PMID:26211929
δ Subunit-containing GABAA receptors are preferred targets for the centrally acting analgesic flupirtine. PMID:26211808
Phosphodiesterase 4D: an enzyme to remember. PMID:26211680
Role for engagement of β-arrestin2 by the transactivated EGFR in agonist-specific regulation of δ receptor activation of ERK1/2. PMID:26211551
β-Blockers have differential effects on the murine asthma phenotype. PMID:26211486
Activity, assay and target data curation and quality in the ChEMBL database. PMID:26201396
Expanding opportunities for mining bioactive chemistry from patents. PMID:26194581
Down-regulation of IL-8 by high-dose vitamin D is specific to hyperinflammatory macrophages and involves mechanisms beyond up-regulation of DUSP1. PMID:26178144
Activating mitochondrial function and haemoglobin expression with EH-201, an inducer of erythropoietin in neuronal cells, reverses memory impairment. PMID:26177968
Eicosapentaenoic acid prevents TCDD-induced oxidative stress and inflammatory response by modulating MAP kinases and redox-sensitive transcription factors. PMID:26177858
A polyspecific drug/proton antiporter mediates diphenhydramine and clonidine transport at the mouse blood-retinal barrier. PMID:26177775
Alterations in perivascular innervation function in mesenteric arteries from offspring of diabetic rats. PMID:26177571
A large-scale crop protection bioassay data set. PMID:26175909
The expanding role of immunopharmacology: IUPHAR Review 16. PMID:26173913
The D1CT-7 mouse model of Tourette syndrome displays sensorimotor gating deficits in response to spatial confinement. PMID:26171666
Neutrophil elastase induces inflammation and pain in mouse knee joints via activation of proteinase-activated receptor-2. PMID:26140667
Dysregulated post-transcriptional control of COX-2 gene expression in gestational diabetic endothelial cells. PMID:26140661
A novel insulinotropic mechanism of whole grain-derived γ-oryzanol via the suppression of local dopamine D2 receptor signalling in mouse islet. PMID:26140534
Synergistic effect of targeting the epidermal growth factor receptor and hyaluronan synthesis in oesophageal squamous cell carcinoma cells. PMID:26140525
Enantioselective inhibition of d-serine transport by (S)-ketamine. PMID:26140427
The novel PAR2 ligand C391 blocks multiple PAR2 signalling pathways in vitro and in vivo. PMID:26140338
Tissue-specific up-regulation of arginase I and II induced by p38 MAPK mediates endothelial dysfunction in type 1 diabetes mellitus. PMID:26140333
Bioinformatics-Aided Venomics. PMID:26110505
Inflammasome activity is essential for one kidney/deoxycorticosterone acetate/salt-induced hypertension in mice. PMID:26103560
Activation of EP4 receptors prevents endotoxin-induced neutrophil infiltration into the airways and enhances microvascular barrier function. PMID:26103450
PKCε phosphorylates α4β2 nicotinic ACh receptors and promotes recovery from desensitization. PMID:26103136
WTC-01, a novel synthetic oxime-flavone compound, destabilizes microtubules in human nasopharyngeal carcinoma cells in vitro and in vivo. PMID:26102991
Genetic deficit of KCa 3.1 channels protects against pulmonary circulatory collapse induced by TRPV4 channel activation. PMID:26102209
Betulinic acid exerts anti-hepatitis C virus activity via the suppression of NF-κB- and MAPK-ERK1/2-mediated COX-2 expression. PMID:26102077
Selective activation of D1 dopamine receptors impairs sensorimotor gating in Long-Evans rats. PMID:26101934
Structure-activity relationships of bumetanide derivatives: correlation between diuretic activity in dogs and inhibition of the human NKCC2A transporter. PMID:26101812
Many InChIs and quite some feat. PMID:26081259
Role of the endocannabinoid system in diabetes and diabetic complications. PMID:26076890
MD-2 as the target of a novel small molecule, L6H21, in the attenuation of LPS-induced inflammatory response and sepsis. PMID:26076332
Pleiotropic, heart rate-independent cardioprotection by ivabradine. PMID:26076181
Inter-study variability of preclinical in vivo safety studies and translational exposure-QTc relationships--a PKPD meta-analysis. PMID:26076100
Gaddum Memorial Lecture 2014: receptors as an evolving concept: from switches to biased microprocessors. PMID:26075971
Angiotensin-(1-7) administration benefits cardiac, renal and progenitor cell function in db/db mice. PMID:26075703
Monoglyceride lipase deficiency causes desensitization of intestinal cannabinoid receptor type 1 and increased colonic μ-opioid receptor sensitivity. PMID:26075589
Genetic predisposition to albuminuria is associated with increased arterial stiffness: role of elastin. PMID:26075500
Ketamine and phencyclidine: the good, the bad and the unexpected. PMID:26075331
Luminal 5-HT stimulates colonic bicarbonate secretion in rats. PMID:26061462
Cannabinoid-dopamine interactions in the physiology and physiopathology of the basal ganglia. PMID:26059564
Mechanism of inhibition of mouse Slo3 (KCa 5.1) potassium channels by quinine, quinidine and barium. PMID:26045093
Effects of acute and chronic sunitinib treatment on cardiac function and calcium/calmodulin-dependent protein kinase II. PMID:26040813
Salvinorin A analogues PR-37 and PR-38 attenuate compound 48/80-induced itch responses in mice. PMID:26040667
Therapeutic targets of triple-negative breast cancer: a review. PMID:26040571
15-Lipoxygenases regulate the production of chemokines in human lung macrophages. PMID:26040494
Identification of matrine as a promising novel drug for hepatic steatosis and glucose intolerance with HSP72 as an upstream target. PMID:26040411
Neurorestoration induced by the HDAC inhibitor sodium valproate in the lactacystin model of Parkinson's is associated with histone acetylation and up-regulation of neurotrophic factors. PMID:26040297
The Akt inhibitor, triciribine, ameliorates chronic hypoxia-induced vascular pruning and TGFβ-induced pulmonary fibrosis. PMID:26033700
Evaluation of drug-induced QT interval prolongation in animal and human studies: a literature review of concordance. PMID:26031452
Sex hormones regulate cerebral drug metabolism via brain miRNAs: down-regulation of brain CYP2D by androgens reduces the analgesic effects of tramadol. PMID:26031356
Constrictor prostanoids and uridine adenosine tetraphosphate: vascular mediators and therapeutic targets in hypertension and diabetes. PMID:26031319
Quinazoline-4-piperidine sulfamides are specific inhibitors of human NPP1 and prevent pathological mineralization of valve interstitial cells. PMID:26031197
Validating the GTP-cyclohydrolase 1-feedback regulatory complex as a therapeutic target using biophysical and in vivo approaches. PMID:26014146
New selective inhibitors of calcium-activated chloride channels - T16A(inh) -A01, CaCC(inh) -A01 and MONNA - what do they inhibit? PMID:26013995
Induction of the inflammatory regulator A20 by gibberellic acid in airway epithelial cells. PMID:26013851
Endothelin ETA receptor/lipid peroxides/COX-2/TGF-β1 signalling underlies aggravated nephrotoxicity caused by cyclosporine plus indomethacin in rats. PMID:26013701
COPD and squamous cell lung cancer: aberrant inflammation and immunity is the common link. PMID:26013585
PDE7 inhibitor TC3.6 ameliorates symptomatology in a model of primary progressive multiple sclerosis. PMID:25994655
Agonist- and antagonist-induced up-regulation of surface 5-HT3 A receptors. PMID:25989383
The GPR 55 agonist, L-α-lysophosphatidylinositol, mediates ovarian carcinoma cell-induced angiogenesis. PMID:25989290
Allosteric modulation of sigma-1 receptors elicits anti-seizure activities. PMID:25989224
IL-1β reduces tonic contraction of mesenteric lymphatic muscle cells, with the involvement of cycloxygenase-2 and prostaglandin E2. PMID:25989136
Prevention of the degeneration of human dopaminergic neurons in an astrocyte co-culture system allowing endogenous drug metabolism. PMID:25989025
Pharmacological actions of nobiletin in the modulation of platelet function. PMID:25988959
The opioid receptors as targets for drug abuse medication. PMID:25988826
Pelitinib (EKB-569) targets the up-regulation of ABCB1 and ABCG2 induced by hyperthermia to eradicate lung cancer. PMID:25988710
Prolyl hydroxylase inhibition corrects functional iron deficiency and inflammation-induced anaemia in rats. PMID:25988595
What can isolated skeletal muscle experiments tell us about the effects of caffeine on exercise performance? PMID:25988508
BJP is linking its articles to the IUPHAR/BPS Guide to PHARMACOLOGY. PMID:25965085
An atypical addition to the chemokine receptor nomenclature: IUPHAR Review 15. PMID:25958743
Dietary salt regulates epithelial sodium channels in rat endothelial cells: adaptation of vasculature to salt. PMID:25953733
Dimethyl fumarate induces necroptosis in colon cancer cells through GSH depletion/ROS increase/MAPKs activation pathway. PMID:25953698
Activation of M3 cholinoceptors attenuates vascular injury after ischaemia/reperfusion by inhibiting the Ca2+/calmodulin-dependent protein kinase II pathway. PMID:25953628
The role of cannabinoids in adult neurogenesis. PMID:25951750
Amyloid β: one of three danger-associated molecules that are secondary inducers of the proinflammatory cytokines that mediate Alzheimer's disease. PMID:25939581
Adenosine A(2A) receptors are necessary and sufficient to trigger memory impairment in adult mice. PMID:25939452
Progressive inflammation-mediated neurodegeneration after traumatic brain or spinal cord injury. PMID:25939377
A novel snake venom-derived GPIb antagonist, anfibatide, protects mice from acute experimental ischaemic stroke and reperfusion injury. PMID:25917571
Imidazole-based alkaloid derivative LCB54-0009 suppresses ocular angiogenesis and lymphangiogenesis in models of experimental retinopathy and corneal neovascularization. PMID:25917462
Pharmacological inhibition of caspase-8 limits lung tumour outgrowth. PMID:25917370
Immunoinflammatory diseases of the central nervous system - the tale of two cytokines. PMID:25917268
Receptors involved in the modulation of guinea pig urinary bladder motility by prostaglandin D2. PMID:25917171
Effect of polyphenolic phytochemicals on ectopic oxidative phosphorylation in rod outer segments of bovine retina. PMID:25917043
Lack of weight gain after angiotensin AT1 receptor blockade in diet-induced obesity is partly mediated by an angiotensin-(1-7)/Mas-dependent pathway. PMID:25906670
Potent anti-inflammatory effects of the narrow spectrum kinase inhibitor RV1088 on rheumatoid arthritis synovial membrane cells. PMID:25891413
The atypical antipsychotics clozapine and olanzapine promote down-regulation and display functional selectivity at human 5-HT7 receptors. PMID:25884989
Rapamycin impairs HPD-induced beneficial effects on glucose homeostasis. PMID:25884889
Model-based prediction of the acute and long-term safety profile of naproxen in rats. PMID:25884765
Simvastatin alleviates cardiac fibrosis induced by infarction via up-regulation of TGF-β receptor III expression. PMID:25884615
Inhibition of breast cancer progression by a novel histone deacetylase inhibitor, LW479, by down-regulating EGFR expression. PMID:25884486
Meningeal blood flow is controlled by H2 S-NO crosstalk activating a HNO-TRPA1-CGRP signalling pathway. PMID:25884403
Aldosterone down-regulates the slowly activated delayed rectifier potassium current in adult guinea pig cardiomyocytes. PMID:25857626
Chloride channels mediate sodium sulphide-induced relaxation in rat uteri. PMID:25857480
Activation of PPAR-δ induces microRNA-100 and decreases the uptake of very low-density lipoprotein in endothelial cells. PMID:25857370
A Sativex(®) -like combination of phytocannabinoids as a disease-modifying therapy in a viral model of multiple sclerosis. PMID:25857324
α1 -Adrenoceptor activation of PKC-ε causes heterologous desensitization of thromboxane receptors in the aorta of spontaneously hypertensive rats. PMID:25857252
Dynasore enhances the formation of mitochondrial antiviral signalling aggregates and endocytosis-independent NF-κB activation. PMID:25850711
A molecular characterization of the agonist binding site of a nematode cys-loop GABA receptor. PMID:25850584
Discovery and pharmacological characterization of a novel potent inhibitor of diacylglycerol-sensitive TRPC cation channels. PMID:25847402
Eugenol dilates mesenteric arteries and reduces systemic BP by activating endothelial cell TRPV4 channels. PMID:25832173
PKPD modelling to predict altered disposition of 1α,25-dihydroxyvitamin D3 in mice due to dose-dependent regulation of CYP27B1 on synthesis and CYP24A1 on degradation. PMID:25829051
Acute morphine affects the rat circadian clock via rhythms of phosphorylated ERK1/2 and GSK3β kinases and Per1 expression in the rat suprachiasmatic nucleus. PMID:25828914
Spinal antinociceptive effects of the novel NOP receptor agonist PWT2-nociceptin/orphanin FQ in mice and monkeys. PMID:25828800
Inflammation in acute CNS injury: a focus on the role of substance P. PMID:25827155
Rapid ventricular pacing-induced postconditioning attenuates reperfusion injury: effects on peroxynitrite, RISK and SAFE pathways. PMID:25827015
Effects of chronic treatment with the new ultra-long-acting β2 -adrenoceptor agonist indacaterol alone or in combination with the β1 -adrenoceptor blocker metoprolol on cardiac remodelling. PMID:25825265
A derivative of epigallocatechin-3-gallate induces apoptosis via SHP-1-mediated suppression of BCR-ABL and STAT3 signalling in chronic myelogenous leukaemia. PMID:25825203
Long-lasting partnership between insulin resistance and endothelial dysfunction: role of metabolic memory. PMID:25825057
Aspirin-induced histone acetylation in endothelial cells enhances synthesis of the secreted isoform of netrin-1 thus inhibiting monocyte vascular infiltration. PMID:25824964
The long-acting β2 -adrenoceptor agonist olodaterol attenuates pulmonary inflammation. PMID:25824824
Zolpidem and eszopiclone prime α1β2γ2 GABAA receptors for longer duration of activity. PMID:25817320
Meta-chlorophenylpiperazine enhances leptin sensitivity in diet-induced obese mice. PMID:25817043
Identification and optimization of 2-aminobenzimidazole derivatives as novel inhibitors of TRPC4 and TRPC5 channels. PMID:25816897
Effective suppression of pro-inflammatory molecules by DHCA via IKK-NF-κB pathway, in vitro and in vivo. PMID:25802070
Microglial M1/M2 polarization and metabolic states. PMID:25800044
Activation of NALP1 inflammasomes in rats with adjuvant arthritis; a novel therapeutic target of carboxyamidotriazole in a model of rheumatoid arthritis. PMID:25799914
Future technology insight: mass spectrometry imaging as a tool in drug research and development. PMID:25766375
cAMP-dependent activation of protein kinase A as a therapeutic target of skin hyperpigmentation by diphenylmethylene hydrazinecarbothioamide. PMID:25766244
A metabolite of Danshen formulae attenuates cardiac fibrosis induced by isoprenaline, via a NOX2/ROS/p38 pathway. PMID:25766073
Atenolol offers better protection than clonidine against cardiac injury in kainic acid-induced status epilepticus. PMID:25765931
3-Iodothyroacetic acid lacks thermoregulatory and cardiovascular effects in vivo. PMID:25765843
Toll-interacting protein contributes to mortality following myocardial infarction through promoting inflammation and apoptosis. PMID:25765712
The TRPA1 channel mediates the analgesic action of dipyrone and pyrazolone derivatives. PMID:25765567
Pharmacological profile of novel psychoactive benzofurans. PMID:25765500
Role of aldehyde dehydrogenase in hypoxic vasodilator effects of nitrite in rats and humans. PMID:25754766
Antidepressants but not antipsychotics have antiepileptogenic effects with limited effects on comorbid depressive-like behaviour in the WAG/Rij rat model of absence epilepsy. PMID:25754610
Salidroside ameliorates insulin resistance through activation of a mitochondria-associated AMPK/PI3K/Akt/GSK3β pathway. PMID:25754463
Seven novel modulators of the analgesic target NaV 1.7 uncovered using a high-throughput venom-based discovery approach. PMID:25754331
Effect of tyrphostin AG879 on Kv 4.2 and Kv 4.3 potassium channels. PMID:25752739
α-Galactosylceramide suppresses murine eosinophil production through interferon-γ-dependent induction of NO synthase and CD95. PMID:25752588
The contribution of astrocytes and microglia to traumatic brain injury. PMID:25752446
Supraspinal actions of nociceptin/orphanin FQ, morphine and substance P in regulating pain and itch in non-human primates. PMID:25752320
Selected ginsenosides of the protopanaxdiol series are novel positive allosteric modulators of P2X7 receptors. PMID:25752193
G Protein-Coupled Receptor (GPCR) Expression in Native Cells: "Novel" endoGPCRs as Physiologic Regulators and Therapeutic Targets. PMID:25737495
Andrographolide derivative AL-1 improves insulin resistance through down-regulation of NF-κB signalling pathway. PMID:25712508
Toll-like receptor 4 contributes to vascular remodelling and endothelial dysfunction in angiotensin II-induced hypertension. PMID:25712370
Effects of receptor tyrosine kinase inhibitors on VEGF165 a- and VEGF165 b-stimulated gene transcription in HEK-293 cells expressing human VEGFR2. PMID:25684635
Pharmacological and electrophysiological characterization of AZSMO-23, an activator of the hERG K(+) channel. PMID:25684549
Inhibiting endocannabinoid biosynthesis: a novel approach to the treatment of constipation. PMID:25684407
Thalamic Kv 7 channels: pharmacological properties and activity control during noxious signal processing. PMID:25684311
Dopamine receptors - IUPHAR Review 13. PMID:25671228
Pharmacological modulation of autophagy to protect cardiomyocytes according to the time windows of ischaemia/reperfusion. PMID:25660104
A novel CGRP-neutralizing Spiegelmer attenuates neurogenic plasma protein extravasation. PMID:25659966
Annexin A1 mimetic peptide controls the inflammatory and fibrotic effects of silica particles in mice. PMID:25659822
HuR mediates the synergistic effects of angiotensin II and IL-1β on vascular COX-2 expression and cell migration. PMID:25653183
Dose-dependent biphasic leptin-induced proliferation is caused by non-specific IL-6/NF-κB pathway activation in human myometrial cells. PMID:25653112
Kaempferol enhances endothelium-dependent relaxation in the porcine coronary artery through activation of large-conductance Ca(2+) -activated K(+) channels. PMID:25652142
The GPR55 agonist lysophosphatidylinositol relaxes rat mesenteric resistance artery and induces Ca(2+) release in rat mesenteric artery endothelial cells. PMID:25652040
Endocannabinoids modulate human blood-brain barrier permeability in vitro. PMID:25651941
Class A1 scavenger receptors in cardiovascular diseases. PMID:25651870
A store-operated calcium channel inhibitor attenuates collagen-induced arthritis. PMID:25651822
A-kinase-anchoring proteins coordinate inflammatory responses to cigarette smoke in airway smooth muscle. PMID:25637608
Pharmacological methyl group donors block skeletal metastasis in vitro and in vivo. PMID:25631332
Characterization of zofenoprilat as an inducer of functional angiogenesis through increased H2 S availability. PMID:25631232
Inhibition of prostate smooth muscle contraction and prostate stromal cell growth by the inhibitors of Rac, NSC23766 and EHT1864. PMID:25631101
Combined treatment with bexarotene and rosuvastatin reduces angiotensin-II-induced abdominal aortic aneurysm in apoE(-/-) mice and angiogenesis. PMID:25630951
Ten things you should know about protein kinases: IUPHAR Review 14. PMID:25630872
DHEA modulates the effect of cortisol on RACK1 expression via interference with the splicing of the glucocorticoid receptor. PMID:25626076
The endoplasmic reticulum stress and the HIF-1 signalling pathways are involved in the neuronal damage caused by chemical hypoxia. PMID:25625917
Involvement of neuronal TGF-β activated kinase 1 in the development of tolerance to morphine-induced antinociception in rat spinal cord. PMID:25625840
Short-term variability in QT interval and ventricular arrhythmias induced by dofetilide are dependent on high-frequency autonomic oscillations. PMID:25625756
A novel selective and orally bioavailable Nav 1.8 channel blocker, PF-01247324, attenuates nociception and sensory neuron excitability. PMID:25625641
The orphan receptor NOR1 participates in isoprenaline-induced cardiac hypertrophy by regulating PARP-1. PMID:25625556
Anxiolytic-like and anxiogenic-like effects of nicotine are regulated via diverse action at β2*nicotinic acetylcholine receptors. PMID:25625469
Metabolic Profiling and Phenotyping of Central Nervous System Diseases: Metabolites Bring Insights into Brain Dysfunctions. PMID:25616565
Regulation of μ and δ opioid receptor functions: involvement of cyclin-dependent kinase 5. PMID:25598508
The long-acting β2 -adrenoceptor agonist, indacaterol, enhances glucocorticoid receptor-mediated transcription in human airway epithelial cells in a gene- and agonist-dependent manner. PMID:25598440
Selective endothelin A receptor antagonism with sitaxentan reduces neointimal lesion size in a mouse model of intraluminal injury. PMID:25598351
Effects of the novel BK (KCa 1.1) channel opener GoSlo-SR-5-130 are dependent on the presence of BKβ subunits. PMID:25598230
The anti-inflammatory mediator palmitoylethanolamide enhances the levels of 2-arachidonoyl-glycerol and potentiates its actions at TRPV1 cation channels. PMID:25598150
In vitro and in vivo regulation of synaptogenesis by the novel antidepressant spadin. PMID:25598009
The orally active urotensin receptor antagonist, KR36676, attenuates cellular and cardiac hypertrophy. PMID:25597918
LPS exacerbates functional and inflammatory responses to ovalbumin and decreases sensitivity to inhaled fluticasone propionate in a guinea pig model of asthma. PMID:25586266
Glucose modulation induces reactive oxygen species and increases P-glycoprotein-mediated multidrug resistance to chemotherapeutics. PMID:25586174
Schizandrin ameliorates ovariectomy-induced memory impairment, potentiates neurotransmission and exhibits antioxidant properties. PMID:25573619
9-Phenanthrol inhibits recombinant and arterial myocyte TMEM16A channels. PMID:25573456
The effects of sigma (σ1) receptor-selective ligands on muscarinic receptor antagonist-induced cognitive deficits in mice. PMID:25573298
NVP-QBE170: an inhaled blocker of the epithelial sodium channel with a reduced potential to induce hyperkalaemia. PMID:25573195
GPCR dimerization in brainstem nuclei contributes to the development of hypertension. PMID:25573074
Glial cell line-derived neurotrophic factor-mediated enhancement of noradrenergic descending inhibition in the locus coeruleus exerts prolonged analgesia in neuropathic pain. PMID:25572945
GPCR-mediated EGF receptor transactivation regulates TRPV4 action in the vasculature. PMID:25572823
Divergent effects of the 'biased' 5-HT1 A receptor agonists F15599 and F13714 in a novel object pattern separation task. PMID:25572672
Relief learning is dependent on NMDA receptor activation in the nucleus accumbens. PMID:25572550
AM841, a covalent cannabinoid ligand, powerfully slows gastrointestinal motility in normal and stressed mice in a peripherally restricted manner. PMID:25572435
Cryptotanshinone, an orally bioactive herbal compound from Danshen, attenuates atherosclerosis in apolipoprotein E-deficient mice: role of lectin-like oxidized LDL receptor-1 (LOX-1). PMID:25572313
Haloperidol inhibits the development of atherosclerotic lesions in LDL receptor knockout mice. PMID:25572138
Beyond traditional pharmacology: new tools and approaches. PMID:25572005
Molecular determinants of positive allosteric modulation of the human metabotropic glutamate receptor 2. PMID:25571949
Ischaemic conditioning: pitfalls on the path to clinical translation. PMID:25560903
Compound 21, a selective agonist of angiotensin AT2 receptors, prevents endothelial inflammation and leukocyte adhesion in vitro and in vivo. PMID:25560767
Stage-dependent benefits and risks of pimobendan in mice with genetic dilated cardiomyopathy and progressive heart failure. PMID:25560565
MPTP-induced changes in hippocampal synaptic plasticity and memory are prevented by memantine through the BDNF-TrkB pathway. PMID:25560396
Human organic anion transporting polypeptide 1A2 (OATP1A2) mediates cellular uptake of all-trans-retinol in human retinal pigmented epithelial cells. PMID:25560245
Transdermal patches: history, development and pharmacology. PMID:25560046
Sodium butyrate epigenetically modulates high-fat diet-induced skeletal muscle mitochondrial adaptation, obesity and insulin resistance through nucleosome positioning. PMID:25559882
Angiotensin-(1-7) attenuates airway remodelling and hyperresponsiveness in a model of chronic allergic lung inflammation. PMID:25559763
Generic GPCR residue numbers - aligning topology maps while minding the gaps. PMID:25541108
'Partial' competition of heterobivalent ligand binding may be mistaken for allosteric interactions: a comparison of different target interaction models. PMID:25537684
Autophagy: an emerging therapeutic target in vascular diseases. PMID:25537552
Novel immunosuppressive agent caerulomycin A exerts its effect by depleting cellular iron content. PMID:25537422
The endocannabinoid system in renal cells: regulation of Na(+) transport by CB1 receptors through distinct cell signalling pathways. PMID:25537261
Advances in receptor conformation research: the quest for functionally selective conformations focusing on the β2-adrenoceptor. PMID:25537131
Renal effects of chronic pharmacological manipulation of CB2 receptors in rats with diet-induced obesity. PMID:25537025
The fibrate gemfibrozil is a NO- and haem-independent activator of soluble guanylyl cyclase: in vitro studies. PMID:25536881
Selective activation of angiotensin AT2 receptors attenuates progression of pulmonary hypertension and inhibits cardiopulmonary fibrosis. PMID:25522140
Steric parameters, molecular modeling and hydropathic interaction analysis of the pharmacology of para-substituted methcathinone analogues. PMID:25522019
Opioid receptors and cardioprotection - 'opioidergic conditioning' of the heart. PMID:25521834
Proteinases, their receptors and inflammatory signalling: the Oxford South Parks Road connection. PMID:25521749
WMJ-S-001, a novel aliphatic hydroxamate derivative, exhibits anti-inflammatory properties via MKP-1 in LPS-stimulated RAW264.7 macrophages. PMID:25521622
Enhanced GABAergic synaptic transmission at VLPAG neurons and potent modulation by oxycodone in a bone cancer pain model. PMID:25521524
Structural apelin analogues: mitochondrial ROS inhibition and cardiometabolic protection in myocardial ischaemia reperfusion injury. PMID:25521429
The Ca(2+) channel inhibitor 2-APB reverses β-amyloid-induced LTP deficit in hippocampus by blocking BAX and caspase-3 hyperactivation. PMID:25521332
High-affinity σ1 protein agonist reduces clinical and pathological signs of experimental autoimmune encephalomyelitis. PMID:25521311
3,3'-Diindolylmethane attenuates LPS-mediated acute liver failure by regulating miRNAs to target IRAK4 and suppress Toll-like receptor signalling. PMID:25521277
A6V polymorphism of the human μ-opioid receptor decreases signalling of morphine and endogenous opioids in vitro. PMID:25521224
The catalytic topoisomerase II inhibitor dexrazoxane induces DNA breaks, ATF3 and the DNA damage response in cancer cells. PMID:25521189
Synergistic anti-tumour effects of tetrandrine and chloroquine combination therapy in human cancer: a potential antagonistic role for p21. PMID:25521075
Chronic exercise normalizes changes in Cav 1.2 and KCa 1.1 channels in mesenteric arteries from spontaneously hypertensive rats. PMID:25440572
AT-1001: a high-affinity α3β4 nAChR ligand with novel nicotine-suppressive pharmacology. PMID:25440006
S1P-induced airway smooth muscle hyperresponsiveness and lung inflammation in vivo: molecular and cellular mechanisms. PMID:25439580
3-iodothyroacetic acid, a metabolite of thyroid hormone, induces itch and reduces threshold to noxious and to painful heat stimuli in mice. PMID:25439265
A novel mechanism for cytoprotection against hypoxic injury: δ-opioid receptor-mediated increase in Nrf2 translocation. PMID:25439010
Quantitative structure-activity relationship analysis of the pharmacology of para-substituted methcathinone analogues. PMID:25438806
The peroxisome proliferator-activated receptors in cardiovascular diseases: experimental benefits and clinical challenges. PMID:25438608
CXCR3 antagonist VUF10085 binds to an intrahelical site distinct from that of the broad spectrum antagonist TAK-779. PMID:25425280
Δ(9) Tetrahydrocannabinol attenuates Staphylococcal enterotoxin B-induced inflammatory lung injury and prevents mortality in mice by modulation of miR-17-92 cluster and induction of T-regulatory cells. PMID:25425209
Melatonin-sulforaphane hybrid ITH12674 induces neuroprotection in oxidative stress conditions by a 'drug-prodrug' mechanism of action. PMID:25425158
Cannabidiol fails to reverse hypothermia or locomotor suppression induced by Δ(9) -tetrahydrocannabinol in Sprague-Dawley rats. PMID:25425111
TRPV4 and K(Ca) ion channels functionally couple as osmosensors in the paraventricular nucleus. PMID:25421636
The role of phosphoinositide-regulated actin reorganization in chemotaxis and cell migration. PMID:25420930
Mitochondrial (dys)function - a factor underlying the variability of efavirenz-induced hepatotoxicity? PMID:25411110
Evidence for annexin A6-dependent plasma membrane remodelling of lipid domains. PMID:25409976
Nuciferine relaxes rat mesenteric arteries through endothelium-dependent and -independent mechanisms. PMID:25409881
Pharmacological profile of opicapone, a third-generation nitrocatechol catechol-O-methyl transferase inhibitor, in the rat. PMID:25409768
Differential sensitivity of TREK-1, TREK-2 and TRAAK background potassium channels to the polycationic dye ruthenium red. PMID:25409575
Clinically used selective oestrogen receptor modulators increase LDL receptor activity in primary human lymphocytes. PMID:25395200
Advances in exploring the role of microRNAs in the pathogenesis, diagnosis and therapy of cardiac diseases in China. PMID:25393505
An analysis of glucocorticoid receptor-mediated gene expression in BEAS-2B human airway epithelial cells identifies distinct, ligand-directed, transcription profiles with implications for asthma therapeutics. PMID:25393397
Role of the MPTP in conditioning the heart - translatability and mechanism. PMID:25393318
Combined inhibition of monoacylglycerol lipase and cyclooxygenases synergistically reduces neuropathic pain in mice. PMID:25393148
Identification of muscarinic receptor subtypes involved in catecholamine secretion in adrenal medullary chromaffin cells by genetic deletion. PMID:25393049
Novel strategies and underlying protective mechanisms of modulation of vagal activity in cardiovascular diseases. PMID:25378088
Caveolins in cardioprotection - translatability and mechanisms. PMID:25377989
Localization of α-adrenoceptors: JR Vane Medal Lecture. PMID:25377869
Interaction between positive allosteric modulators and trapping blockers of the NMDA receptor channel. PMID:25377730
Therapeutic action of 5-HT3 receptor antagonists targeting peritoneal macrophages in post-operative ileus. PMID:25377620
AQW051, a novel, potent and selective α7 nicotinic ACh receptor partial agonist: pharmacological characterization and phase I evaluation. PMID:25363835
The phytocannabinoid, Δ⁹-tetrahydrocannabivarin, can act through 5-HT₁A receptors to produce antipsychotic effects. PMID:25363799
Novel Nrf2 activators from microbial transformation products inhibit blood-retinal barrier permeability in rabbits. PMID:25363737
MLN4924 sensitizes monocytes and maturing dendritic cells for TNF-dependent and -independent necroptosis. PMID:25363690
Differential activation of human constitutive androstane receptor and its SV23 and SV24 splice variants by rilpivirine and etravirine. PMID:25363652
The virtual heart as a platform for screening drug cardiotoxicity. PMID:25363597
Protective effect of 23-hydroxybetulinic acid on doxorubicin-induced cardiotoxicity: a correlation with the inhibition of carbonyl reductase-mediated metabolism. PMID:25363561
Noble gases as cardioprotectants - translatability and mechanism. PMID:25363501
FM19G11 reverses endothelial dysfunction in rat and human arteries through stimulation of the PI3K/Akt/eNOS pathway, independently of mTOR/HIF-1α activation. PMID:25363469
Synthesis and SAR studies of novel 6,7,8-substituted 4-substituted benzyloxyquinolin-2(1H)-one derivatives for anticancer activity. PMID:25363404
Regulator of G-protein signalling 5 protects against atherosclerosis in apolipoprotein E-deficient mice. PMID:25363362
Localization of sunitinib, its metabolites and its target receptors in tumour-bearing mice: a MALDI-MS imaging study. PMID:25363319
Histamine H₄ receptors in the gastrointestinal tract. PMID:25363289
Inhibition of L-carnitine biosynthesis and transport by methyl-γ-butyrobetaine decreases fatty acid oxidation and protects against myocardial infarction. PMID:25363063
The activation of supraspinal GPR40/FFA1 receptor signalling regulates the descending pain control system. PMID:25362997
Genistein alleviates pressure overload-induced cardiac dysfunction and interstitial fibrosis in mice. PMID:25362897
Rotigotine is a potent agonist at dopamine D1 receptors as well as at dopamine D2 and D3 receptors. PMID:25339241
Activation of TRPV1 attenuates high salt-induced cardiac hypertrophy through improvement of mitochondrial function. PMID:25339153
Aspirin enhances protective effect of fish oil against thrombosis and injury-induced vascular remodelling. PMID:25339093
TRPM4 inhibitor 9-phenanthrol activates endothelial cell intermediate conductance calcium-activated potassium channels in rat isolated mesenteric artery. PMID:25323322
Carbon nanomaterials combined with metal nanoparticles for theranostic applications. PMID:25323135
Oestrogen inhibits BMP4-induced BMP4 expression in cardiomyocytes: a potential mechanism of oestrogen-mediated protection against cardiac hypertrophy. PMID:25323043
Indoline-3-propionate and 3-aminopropyl carbamates reduce lung injury and pro-inflammatory cytokines induced in mice by LPS. PMID:25322956
Anaesthetics as cardioprotectants: translatability and mechanism. PMID:25322898
Annexin A2 complexes with S100 proteins: structure, function and pharmacological manipulation. PMID:25303710
Unravelling the theories of pre-eclampsia: are the protective pathways the new paradigm? PMID:25303561
Postconditioning signalling in the heart: mechanisms and translatability. PMID:25303373
Redox signalling and cardioprotection: translatability and mechanism. PMID:25303224
Extending the translational potential of targeting NO/cGMP-regulated pathways in the CVS. PMID:25302549
Physiological, pharmacological and toxicological considerations of drug-induced structural cardiac injury. PMID:25302413
Spinal blockage of P/Q- or N-type voltage-gated calcium channels modulates functional and symptomatic changes related to haemorrhagic cystitis in mice. PMID:25298144
Biased β2-adrenoceptor signalling in heart failure: pathophysiology and drug discovery. PMID:25298054
Serelaxin-mediated signal transduction in human vascular cells: bell-shaped concentration-response curves reflect differential coupling to G proteins. PMID:25297987
κ-Opioid receptors are not necessary for the antidepressant treatment of neuropathic pain. PMID:25297905
Biphasic modulation by mGlu5 receptors of TRPV1-mediated intracellular calcium elevation in sensory neurons contributes to heat sensitivity. PMID:25297838
Ketamine coadministration attenuates morphine tolerance and leads to increased brain concentrations of both drugs in the rat. PMID:25297798
Hydrogen sulphide protects against NSAID-enteropathy through modulation of bile and the microbiota. PMID:25297699
A novel compound VSC2 has anti-inflammatory and antioxidant properties in microglia and in Parkinson's disease animal model. PMID:25297649
Cardiac NO signalling in the metabolic syndrome. PMID:25297560
Diadenosine tetraphosphate induces tight junction disassembly thus increasing corneal epithelial permeability. PMID:25297531
The cGMP/PKG pathway as a common mediator of cardioprotection: translatability and mechanism. PMID:25297462
Molecular mechanisms governing different pharmacokinetics of ginsenosides and potential for ginsenoside-perpetrated herb-drug interactions on OATP1B3. PMID:25297453
Urinary bladder inflammation induces changes in urothelial nerve growth factor and TRPV1 channels. PMID:25297375
Protective effects of n-6 fatty acids-enriched diet on intestinal ischaemia/reperfusion injury involve lipoxin A4 and its receptor. PMID:25296998
Presynaptic adenosine A2A receptors dampen cannabinoid CB1 receptor-mediated inhibition of corticostriatal glutamatergic transmission. PMID:25296982
The endocannabinoid system regulates synaptic transmission in nucleus accumbens by increasing DAGL-α expression following short-term morphine withdrawal. PMID:25296881
The effects of microRNA on the absorption, distribution, metabolism and excretion of drugs. PMID:25296724
Kv 11.1 (hERG)-induced cardiotoxicity: a molecular insight from a binding kinetics study of prototypical Kv 11.1 (hERG) inhibitors. PMID:25296617
Targeting two-pore domain K(+) channels TREK-1 and TASK-3 for the treatment of depression: a new therapeutic concept. PMID:25263033
Pharmacological targeting of GSK3β confers protection against podocytopathy and proteinuria by desensitizing mitochondrial permeability transition. PMID:25262943
Preventing leptin resistance by blocking angiotensin II AT1 receptors in diet-induced obese rats. PMID:25258168
Inhibition of monoacylglycerol lipase reduces nicotine withdrawal. PMID:25258021
Sonic hedgehog increases the skin wound-healing ability of mouse embryonic stem cells through the microRNA 200 family. PMID:25257936
Tubulin acetylation promoting potency and absorption efficacy of deacetylase inhibitors. PMID:25257800
Targeting the cis-dimerization of LINGO-1 with low MW compounds affects its downstream signalling. PMID:25257685
Are cannabidiol and Δ(9) -tetrahydrocannabivarin negative modulators of the endocannabinoid system? A systematic review. PMID:25257544
Stereochemistry of mephedrone neuropharmacology: enantiomer-specific behavioural and neurochemical effects in rats. PMID:25255824
Activation of PPARδ: from computer modelling to biological effects. PMID:25255770
Selective targeting of glucagon-like peptide-1 signalling as a novel therapeutic approach for cardiovascular disease in diabetes. PMID:25231355
Hunting for the function of orphan GPCRs - beyond the search for the endogenous ligand. PMID:25231237
Rare platelet GPCR variants: what can we learn? PMID:25231155
Protective role of olesoxime against wild-type α-synuclein-induced toxicity in human neuronally differentiated SHSY-5Y cells. PMID:25220617
The sphingosine 1-phosphate receptor agonist FTY720 is neuroprotective after cuprizone-induced CNS demyelination. PMID:25220526
Biased allosteric modulation at the CaS receptor engendered by structurally diverse calcimimetics. PMID:25220431
Ionic mechanisms underlying the negative chronotropic action of propofol on sinoatrial node automaticity in guinea pig heart. PMID:25220338
YM155 down-regulates survivin and XIAP, modulates autophagy and induces autophagy-dependent DNA damage in breast cancer cells. PMID:25220225
Hydrogen peroxide stimulation of CFTR reveals an Epac-mediated, soluble AC-dependent cAMP amplification pathway common to GPCR signalling. PMID:25220136
Remote conditioning the heart overview: translatability and mechanism. PMID:25219984
Effect of erythropoietin on hepatic cytochrome P450 expression and function in an adenine-fed rat model of chronic kidney disease. PMID:25219905
Palmitoylethanolamide, a naturally occurring lipid, is an orally effective intestinal anti-inflammatory agent. PMID:25205418
The role of adenylyl cyclase isoform 6 in β-adrenoceptor signalling in murine airways. PMID:25205328
Preclinical development of AMG 139, a human antibody specifically targeting IL-23. PMID:25205227
Signalling pathways and mechanisms of protection in pre- and postconditioning: historical perspective and lessons for the future. PMID:25205071
Extracellular signalling molecules in the ischaemic/reperfused heart - druggable and translatable for cardioprotection? PMID:25204973
p38 MAPK in cardioprotection - are we there yet? PMID:25204838
Emerging role of hydrogen sulfide in hypertension and related cardiovascular diseases. PMID:25204754
The role of hexokinase in cardioprotection - mechanism and potential for translation. PMID:25204670
Structure-function analysis of apical membrane-associated molecules of the tegument of schistosome parasites of humans: prospects for identification of novel targets for parasite control. PMID:25176442
Oxidized LDL-induced angiogenesis involves sphingosine 1-phosphate: prevention by anti-S1P antibody. PMID:25176316
Auto-inhibition at a ligand-gated ion channel: a cross-talk between orthosteric and allosteric sites. PMID:25176133
The non-peptide GLP-1 receptor agonist WB4-24 blocks inflammatory nociception by stimulating β-endorphin release from spinal microglia. PMID:25176008
Side effect profile of 5-HT treatments for Parkinson's disease and L-DOPA-induced dyskinesia in rats. PMID:25175895
In vitro, in vivo and ex vivo characterization of ibrutinib: a potent inhibitor of the efflux function of the transporter MRP1. PMID:25164592
A non-erythropoietic peptide derivative of erythropoietin decreases susceptibility to diet-induced insulin resistance in mice. PMID:25164531
Fluoxetine elevates allopregnanolone in female rat brain but inhibits a steroid microsomal dehydrogenase rather than activating an aldo-keto reductase. PMID:25161074
Effects of caffeine on circadian phase, amplitude and period evaluated in cells in vitro and peripheral organs in vivo in PER2::LUCIFERASE mice. PMID:25160990
σ1 receptors activate astrocytes via p38 MAPK phosphorylation leading to the development of mechanical allodynia in a mouse model of neuropathic pain. PMID:25158784
Compound A, a selective glucocorticoid receptor agonist, inhibits immunoinflammatory diabetes, induced by multiple low doses of streptozotocin in mice. PMID:25158597
The ceramide kinase inhibitor NVP-231 inhibits breast and lung cancer cell proliferation by inducing M phase arrest and subsequent cell death. PMID:25134723
DNA demethylation and invasive cancer: implications for therapeutics. PMID:25134627
Calcium affects OX1 orexin (hypocretin) receptor responses by modifying both orexin binding and the signal transduction machinery. PMID:25132134
A-kinase anchoring proteins: cAMP compartmentalization in neurodegenerative and obstructive pulmonary diseases. PMID:25132049
The interferon regulatory factors as novel potential targets in the treatment of cardiovascular diseases. PMID:25131895
4-bromopropofol decreases action potential generation in spinal neurons by inducing a glycine receptor-mediated tonic conductance. PMID:25131750
Characterizing pharmacological ligands to study the long-chain fatty acid receptors GPR40/FFA1 and GPR120/FFA4. PMID:25131623
Endothelin@25 - new agonists, antagonists, inhibitors and emerging research frontiers: IUPHAR Review 12. PMID:25131455
Treatment with melatonin after onset of experimental uveitis attenuates ocular inflammation. PMID:25131343
Protons modulate perivascular axo-axonal neurotransmission in the rat mesenteric artery. PMID:25117291
Structural basis for constitutive activity and agonist-induced activation of the enteroendocrine fat sensor GPR119. PMID:25117266
IL-1β and IL-18: inflammatory markers or mediators of hypertension? PMID:25117218
Neuroprotective effects of the anti-cancer drug sunitinib in models of HIV neurotoxicity suggests potential for the treatment of neurodegenerative disorders. PMID:25117211
The neurosteroid 5β-pregnan-3α-ol-20-one enhances actions of etomidate as a positive allosteric modulator of α1β2γ2L GABAA receptors. PMID:25117207
Cyclin-dependent kinase 5 is involved in the phosphorylation of gephyrin and clustering of GABAA receptors at inhibitory synapses of hippocampal neurons. PMID:25093719
PPemd26, an anthraquinone derivative, suppresses angiogenesis via inhibiting VEGFR2 signalling. PMID:25091695
Autocrine secretion of 15d-PGJ2 mediates simvastatin-induced apoptotic burst in human metastatic melanoma cells. PMID:25091578
Endothelin-1 contributes to endothelial dysfunction and enhanced vasoconstriction through augmented superoxide production in penile arteries from insulin-resistant obese rats: role of ET(A) and ET(B) receptors. PMID:25091502
Hydrogen sulfide: physiological properties and therapeutic potential in ischaemia. PMID:25091411
The behavioural response of mice lacking NK₁ receptors to guanfacine resembles its clinical profile in treatment of ADHD. PMID:25074741
Dopamine D1 and corticotrophin-releasing hormone type-2α receptors assemble into functionally interacting complexes in living cells. PMID:25073922
Selective Na(+) /Ca(2+) exchanger inhibition prevents Ca(2+) overload-induced triggered arrhythmias. PMID:25073832
Endothelial atypical cannabinoid receptor: do we have enough evidence? PMID:25073723
Epigenetics in the perioperative period. PMID:25073649
Simulation with cells in vitro of tamoxifen treatment in premenopausal breast cancer patients with different CYP2D6 genotypes. PMID:25073551
1E7-03, a low MW compound targeting host protein phosphatase-1, inhibits HIV-1 transcription. PMID:25073485
Molecular targets of the multifunctional iron-chelating drug, M30, in the brains of mouse models of type 2 diabetes mellitus. PMID:25073425
Roscovitine is a proteostasis regulator that corrects the trafficking defect of F508del-CFTR by a CDK-independent mechanism. PMID:25065395
Epigenetic pathway targets for the treatment of disease: accelerating progress in the development of pharmacological tools: IUPHAR Review 11. PMID:25060293
Detection of the secondary, low-affinity β1 -adrenoceptor site in living cells using the fluorescent CGP 12177 derivative BODIPY-TMR-CGP. PMID:25052258
δ-Opioid receptors up-regulate excitatory amino acid transporters in mouse astrocytes. PMID:25052197
Alteration of vascular reactivity in heart failure: role of phosphodiesterases 3 and 4. PMID:25048877
In vivo properties of KNT-127, a novel δ opioid receptor agonist: receptor internalization, antihyperalgesia and antidepressant effects in mice. PMID:25048778
Analgesic tolerance to morphine is regulated by PPARγ. PMID:25048682
Heteromerization of GPR55 and cannabinoid CB2 receptors modulates signalling. PMID:25048571
Mechanisms underlying the cytotoxicity of a novel quinazolinedione-based redox modulator, QD232, in pancreatic cancer cells. PMID:25047070
Therapeutic perspectives of epigenetically active nutrients. PMID:25046997
Nicotinic acetylcholine receptors control acetylcholine and noradrenaline release in the rodent habenulo-interpeduncular complex. PMID:25041479
TRPC6 regulates cell cycle progression by modulating membrane potential in bone marrow stromal cells. PMID:25041367
Endocannabinoid modulation by FAAH and monoacylglycerol lipase within the analgesic circuitry of the periaqueductal grey. PMID:25041240
Celastrol protects ischaemic myocardium through a heat shock response with up-regulation of haeme oxygenase-1. PMID:25041185
Ursodeoxycholyl lysophosphatidylethanolamide attenuates hepatofibrogenesis by impairment of TGF-β1/Smad2/3 signalling. PMID:25041068
Molecular mechanism of allosteric modulation at GPCRs: insight from a binding kinetics study at the human A1 adenosine receptor. PMID:25040887
Glutathione administration reduces mitochondrial damage and shifts cell death from necrosis to apoptosis in ageing diabetic mice hearts during exercise. PMID:25039894
Metabolic characteristics of 13-cis-retinoic acid (isotretinoin) and anti-tumour activity of the 13-cis-retinoic acid metabolite 4-oxo-13-cis-retinoic acid in neuroblastoma. PMID:25039756
Identification of novel insulin mimetic drugs by quantitative total internal reflection fluorescence (TIRF) microscopy. PMID:25039620
Targeting the histone orthography of cancer: drugs for writers, erasers and readers. PMID:25039449
Novel coumarin modified GLP-1 derivatives with enhanced plasma stability and prolonged in vivo glucose-lowering ability. PMID:25039358
Determination of the binding mode for the cyclopentapeptide CXCR4 antagonist FC131 using a dual approach of ligand modifications and receptor mutagenesis. PMID:25039237
Identifying bias in CCR1 antagonists using radiolabelled binding, receptor internalization, β-arrestin translocation and chemotaxis assays. PMID:24990525
Treatment with LPS plus INF-γ induces the expression and function of muscarinic acetylcholine receptors, modulating NIH3T3 cell proliferation: participation of NOS and COX. PMID:24990429
Endothelin-converting enzyme 2 differentially regulates opioid receptor activity. PMID:24990314
Measurement of NO in biological samples. PMID:24990201
Different apoptotic effects of [Pt(O,O'-acac)(γ-acac)(DMS)] and cisplatin on normal and cancerous human epithelial breast cells in primary culture. PMID:24990093
Conformational flexibility of the agonist binding jaw of the human P2X3 receptor is a prerequisite for channel opening. PMID:24989924
Therapeutic interventions in sepsis: current and anticipated pharmacological agents. PMID:24977655
Synthetic (+)-antroquinonol exhibits dual actions against insulin resistance by triggering AMP kinase and inhibiting dipeptidyl peptidase IV activities. PMID:24977411
S-nitrosation and neuronal plasticity. PMID:24962517
Exogenous administration of thiosulfate, a donor of hydrogen sulfide, attenuates angiotensin II-induced hypertensive heart disease in rats. PMID:24962324
Drug effects on the CVS in conscious rats: separating cardiac output into heart rate and stroke volume using PKPD modelling. PMID:24962208
Anti-IL-31 receptor antibody is shown to be a potential therapeutic option for treating itch and dermatitis in mice. PMID:24946165
PKC inhibition results in a Kv 1.5 + Kv β1.3 pharmacology closer to Kv 1.5 channels. PMID:24946104
(4-[6-(4-isopropoxyphenyl)pyrazolo [1,5-a]pyrimidin-3-yl] quinoline) is a novel inhibitor of autophagy. PMID:24943256
Small-molecule modulators of the OX40-OX40 ligand co-stimulatory protein-protein interaction. PMID:24930776
The role of opioid processes in reward and decision-making. PMID:24930675
An in vivo role for Rho kinase activation in the tumour vascular disrupting activity of combretastatin A-4 3-O-phosphate. PMID:24930520
Lipoxin A4 suppresses the development of endometriosis in an ALX receptor-dependent manner via the p38 MAPK pathway. PMID:24923883
Multiple roles of the PGE2 -EP receptor signal in vascular permeability. PMID:24923772
Synthetic gestagens exert differential effects on arterial thrombosis and aortic gene expression in ovariectomized apolipoprotein E-deficient mice. PMID:24923668
Pharmacologically distinct phenotypes of α1B -adrenoceptors: variation in binding and functional affinities for antagonists. PMID:24923551
Evaluation of peripheral versus central effects of GABA(B) receptor activation using a novel, positive allosteric modulator of the GABA(B) receptor ADX71943, a pharmacological tool compound with a fully peripheral activity profile. PMID:24923436
The role of gasotransmitters NO, H2S and CO in myocardial ischaemia/reperfusion injury and cardioprotection by preconditioning, postconditioning and remote conditioning. PMID:24923364
Anti-nociception mediated by a κ opioid receptor agonist is blocked by a δ receptor agonist. PMID:24923251
Repeated morphine treatment alters cannabinoid modulation of GABAergic synaptic transmission within the rat periaqueductal grey. PMID:24916363
Revolution in GPCR signalling: opioid receptor heteromers as novel therapeutic targets: IUPHAR review 10. PMID:24916280
Molecular basis of agonist docking in a human GPR103 homology model by site-directed mutagenesis and structure-activity relationship studies. PMID:24913445
Specific regions display altered grey matter volume in μ-opioid receptor knockout mice: MRI voxel-based morphometry. PMID:24913308
Targeting multiple cannabinoid anti-tumour pathways with a resorcinol derivative leads to inhibition of advanced stages of breast cancer. PMID:24910342
Purinergic neuromuscular transmission in the gastrointestinal tract; functional basis for future clinical and pharmacological studies. PMID:24910216
Pharmacological tools for hydrogen sulphide research: a brief, introductory guide for beginners. PMID:24909294
Vasorelaxant effects of novel Kv 7.4 channel enhancers ML213 and NS15370. PMID:24909207
Emodin inhibits tonic tension through suppressing PKCδ-mediated inhibition of myosin phosphatase in rat isolated thoracic aorta. PMID:24909118
Molecular determinants for the high constitutive activity of the human histamine H4 receptor: functional studies on orthologues and mutants. PMID:24903527
Identification of an old antibiotic clofoctol as a novel activator of unfolded protein response pathways and an inhibitor of prostate cancer. PMID:24903412
In vitro and in vivo pharmacological characterization of nociceptin/orphanin FQ tetrabranched derivatives. PMID:24903280
A novel 1,2-benzenediamine derivative FC-99 suppresses TLR3 expression and ameliorates disease symptoms in a mouse model of sepsis. PMID:24903157
BU08073 a buprenorphine analogue with partial agonist activity at μ-receptors in vitro but long-lasting opioid antagonist activity in vivo in mice. PMID:24903063
Quercetin attenuates doxorubicin cardiotoxicity by modulating Bmi-1 expression. PMID:24902966
PAR1-dependent COX-2/PGE2 production contributes to cell proliferation via EP2 receptors in primary human cardiomyocytes. PMID:24902855
Controlling the activation of the Bv8/prokineticin system reduces neuroinflammation and abolishes thermal and tactile hyperalgesia in neuropathic animals. PMID:24902717
Pharmacological regulators of autophagy and their link with modulators of lupus disease. PMID:24902607
CFTR potentiators partially restore channel function to A561E-CFTR, a cystic fibrosis mutant with a similar mechanism of dysfunction as F508del-CFTR. PMID:24902474
Effect of naltrexone on neuropathic pain in mice locally transfected with the mutant μ-opioid receptor gene in spinal cord. PMID:24866991
Pharmacological manipulations in animal models of anorexia and binge eating in relation to humans. PMID:24866852
Mexiletine as a treatment for primary erythromelalgia: normalization of biophysical properties of mutant L858F NaV 1.7 sodium channels. PMID:24866741
Convergent pharmacological mechanisms in impulsivity and addiction: insights from rodent models. PMID:24866553
The blockade of transient receptor potential ankirin 1 (TRPA1) signalling mediates antidepressant- and anxiolytic-like actions in mice. PMID:24846744
Buprenorphine signalling is compromised at the N40D polymorphism of the human μ opioid receptor in vitro. PMID:24846673
Orexin A activates hypoglossal motoneurons and enhances genioglossus muscle activity in rats. PMID:24846570
Multimodal antidepressant vortioxetine increases frontal cortical oscillations unlike escitalopram and duloxetine--a quantitative EEG study in rats. PMID:24846338
Pharmacological bronchodilation is partially mediated by reduced airway wall stiffness. PMID:24846164
Ulinastatin activates haem oxygenase 1 antioxidant pathway and attenuates allergic inflammation. PMID:24835359
A formyl peptide receptor agonist suppresses inflammation and bone damage in arthritis. PMID:24824742
Therapeutic use of botulinum toxin in migraine: mechanisms of action. PMID:24819339
Palmitoylethanolamide normalizes intestinal motility in a model of post-inflammatory accelerated transit: involvement of CB₁ receptors and TRPV1 channels. PMID:24818658
Lysophospholipid receptor nomenclature review: IUPHAR Review 8. PMID:24602016
Update on leukotriene, lipoxin and oxoeicosanoid receptors: IUPHAR Review 7. PMID:24588652
Challenges for opioid receptor nomenclature: IUPHAR Review 9. PMID:24528283
A new histone deacetylase inhibitor improves liver fibrosis in BDL rats through suppression of hepatic stellate cells. PMID:24467283
Fine-tuning somatostatin receptor signalling by agonist-selective phosphorylation and dephosphorylation: IUPHAR Review 5. PMID:24328848
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79 articles citing: The IUPHAR/BPS Guide to PHARMACOLOGY in 2020: extending immunopharmacology content and introducing the IUPHAR/MMV Guide to MALARIA PHARMACOLOGY

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In-silico screening and in-vitro assay show the antiviral effect of Indomethacin against SARS-CoV-2. PMID:35809412
StarGazer: A Hybrid Intelligence Platform for Drug Target Prioritization and Digital Drug Repositioning Using Streamlit. PMID:35711912
Investigation of the mechanism of Shen Qi Wan prescription in the treatment of T2DM via network pharmacology and molecular docking. PMID:35673584
Mapping and Validation of scRNA-Seq-Derived Cell-Cell Communication Networks in the Tumor Microenvironment. PMID:35572582
Angiotensin and Endothelin Receptor Structures With Implications for Signaling Regulation and Pharmacological Targeting. PMID:35518926
Common coupling map advances GPCR-G protein selectivity. PMID:35302494
DeepREAL: A Deep Learning Powered Multi-scale Modeling Framework for Predicting Out-of-distribution Ligand-induced GPCR Activity. PMID:35274689
Discovery of Kinase and Carbonic Anhydrase Dual Inhibitors by Machine Learning Classification and Experiments. PMID:35215348
A Proximal-to-Distal Survey of Healthy Adult Human Small Intestine and Colon Epithelium by Single-Cell Transcriptomics. PMID:35176508
Unravelling Mechanisms of Doxorubicin-Induced Toxicity in 3D Human Intestinal Organoids. PMID:35163210
Machine learning prediction and tau-based screening identifies potential Alzheimer's disease genes relevant to immunity. PMID:35149761
Reduced expression of the psychiatric risk gene DLG2 (PSD93) impairs hippocampal synaptic integration and plasticity. PMID:35115661
MAP Bayesian modelling combining striatal dopamine receptor occupancy and plasma concentrations to optimize antipsychotic dose regimens in individual patients. PMID:35112390
Towards Drug Repurposing in Cancer Cachexia: Potential Targets and Candidates. PMID:34832866
VARIDT 2.0: structural variability of drug transporter. PMID:34747471
Path4Drug: Data Science Workflow for Identification of Tissue-Specific Biological Pathways Modulated by Toxic Drugs. PMID:34721010
The IUPHAR/BPS guide to PHARMACOLOGY in 2022: curating pharmacology for COVID-19, malaria and antibacterials. PMID:34718737
Therapeutic target database update 2022: facilitating drug discovery with enriched comparative data of targeted agents. PMID:34718717
Long-term antagonism and allosteric regulation of mu opioid receptors by the novel ligand, methocinnamox. PMID:34713624
NCATS Inxight Drugs: a comprehensive and curated portal for translational research. PMID:34648031
Comprehensive Survey of Recent Drug Discovery Using Deep Learning. PMID:34576146
The G protein database, GproteinDb. PMID:34570219
A practical guide to large-scale docking. PMID:34561691
Will the chemical probes please stand up? PMID:34447939
An Overview of Cell-Based Assay Platforms for the Solute Carrier Family of Transporters. PMID:34447313
Biomolecule and Bioentity Interaction Databases in Systems Biology: A Comprehensive Review. PMID:34439912
MRGPRX2 and Adverse Drug Reactions. PMID:34421893
Exploring Chemical Information in PubChem. PMID:34370395
CellCall: integrating paired ligand-receptor and transcription factor activities for cell-cell communication. PMID:34331449
Discovering and Summarizing Relationships Between Chemicals, Genes, Proteins, and Diseases in PubChem. PMID:34322655
Ligands of Adrenergic Receptors: A Structural Point of View. PMID:34202543
The Role of GIP Receptor in the CNS for the Pathogenesis of Obesity. PMID:34176784
A549 in-silico 1.0: A first computational model to simulate cell cycle dependent ion current modulation in the human lung adenocarcinoma. PMID:34157016
G-protein-coupled receptor GPR17 inhibits glioma development by increasing polycomb repressive complex 1-mediated ROS production. PMID:34120140
Seeking the exclusive binding region of phenylalkylamine derivatives on human T-type calcium channels via homology modeling and molecular dynamics simulation approach. PMID:33984189
Knowledge bases and software support for variant interpretation in precision oncology. PMID:33971666
Arena3Dweb: interactive 3D visualization of multilayered networks. PMID:33885790
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Improved sequence-based prediction of interaction sites in α-helical transmembrane proteins by deep learning. PMID:33815689
Integrated intra- and intercellular signaling knowledge for multicellular omics analysis. PMID:33749993
The Oxford Catalogue of Opioids: A systematic synthesis of opioid drug names and their pharmacology. PMID:33608948
Patient-tailored design for selective co-inhibition of leukemic cell subpopulations. PMID:33608276
Expression and Distribution of Neuropeptide-Expressing Cells Throughout the Rodent Paraventricular Nucleus of the Thalamus. PMID:33584216
Current and prospective computational approaches and challenges for developing COVID-19 vaccines. PMID:33561453
Intense bitterness of molecules: Machine learning for expediting drug discovery. PMID:33510862
Cellinker: a platform of ligand-receptor interactions for intercellular communication analysis. PMID:33471060
Pruritus in psoriasis and atopic dermatitis: current treatments and new perspectives. PMID:33460006
The Ion Channel and GPCR Toolkit of Brain Capillary Pericytes. PMID:33390906
Integrated Bioinformatics Analysis for the Screening of Associated Pathways and Therapeutic Drugs in Coronavirus Disease 2019. PMID:33309308
Integration of the Drug-Gene Interaction Database (DGIdb 4.0) with open crowdsource efforts. PMID:33237278
GPCR-PEnDB: a database of protein sequences and derived features to facilitate prediction and classification of G protein-coupled receptors. PMID:33216895
WikiPathways: connecting communities. PMID:33211851
FunRes: resolving tissue-specific functional cell states based on a cell-cell communication network model. PMID:33179736
A Workflow of Integrated Resources to Catalyze Network Pharmacology Driven COVID-19 Research. PMID:33173863
COVID19 Drug Repository: text-mining the literature in search of putative COVID19 therapeutics. PMID:33166390
Individuating Possibly Repurposable Drugs and Drug Targets for COVID-19 Treatment Through Hypothesis-Driven Systems Medicine Using CoVex. PMID:33164550
TCRD and Pharos 2021: mining the human proteome for disease biology. PMID:33156327
PubChem in 2021: new data content and improved web interfaces. PMID:33151290
KLIFS: an overhaul after the first 5 years of supporting kinase research. PMID:33084889
SynPharm and the guide to pharmacology database: A toolset for conferring drug control on engineered proteins. PMID:33047381
Single-nucleus characterization of adult mouse spinal dynorphin-lineage cells and identification of persistent transcriptional effects of neonatal hindpaw incision. PMID:33045156
PROTAC-DB: an online database of PROTACs. PMID:33010159
Advances in Genomics for Drug Development. PMID:32824125
Agonist-induced formation of unproductive receptor-G12 complexes. PMID:32817560
Exploring the SARS-CoV-2 virus-host-drug interactome for drug repurposing. PMID:32665542
Advancing computer-aided drug discovery (CADD) by big data and data-driven machine learning modeling. PMID:32663517
Noradrenergic tone mediates marble burying behavior after chronic stress and ethanol. PMID:32588079
A SARS-CoV-2-Human Protein-Protein Interaction Map Reveals Drug Targets and Potential Drug-Repurposing. PMID:32511329
Regenerative medicine therapies: lessons from the kidney. PMID:32467861
DRUGPATH: The Drug Gene Pathway Meta-Database. PMID:32365960
A SARS-CoV-2 protein interaction map reveals targets for drug repurposing. PMID:32353859
Inhibitory checkpoints in human natural killer cells: IUPHAR Review 28. PMID:32335915
A hypothesis for pathobiology and treatment of COVID-19: The centrality of ACE1/ACE2 imbalance. PMID:32333398
Guide to Immunopharmacology: a database to boost immunology education, research and therapy. PMID:32297319
Opening up connectivity between documents, structures and bioactivity. PMID:32280387
The IUPHAR Guide to Immunopharmacology: connecting immunology and pharmacology. PMID:32020584
The 27th annual Nucleic Acids Research database issue and molecular biology database collection. PMID:31906604
The Emerging Role of Cytidine Deaminase in Human Diseases: A New Opportunity for Therapy? PMID:31870623
IUPHAR-DB: new receptors and tools for easy searching and visualization of pharmacological data PubMed citations: 62.

62 articles citing: IUPHAR-DB: new receptors and tools for easy searching and visualization of pharmacological data

Mapping and Validation of scRNA-Seq-Derived Cell-Cell Communication Networks in the Tumor Microenvironment. PMID:35572582
The IUPHAR/BPS guide to PHARMACOLOGY in 2022: curating pharmacology for COVID-19, malaria and antibacterials. PMID:34718737
Applications and analytical tools of cell communication based on ligand-receptor interactions at single cell level. PMID:34217372
The A818-6 system as an in-vitro model for studying the role of the transportome in pancreatic cancer. PMID:32228510
The IUPHAR Guide to Immunopharmacology: connecting immunology and pharmacology. PMID:32020584
The IUPHAR/BPS Guide to PHARMACOLOGY in 2020: extending immunopharmacology content and introducing the IUPHAR/MMV Guide to MALARIA PHARMACOLOGY. PMID:31691834
Expression of potassium channel genes predicts clinical outcome in lung cancer. PMID:31680775
Expression map of 78 brain-expressed mouse orphan GPCRs provides a translational resource for neuropsychiatric research. PMID:30271982
The IUPHAR/BPS Guide to PHARMACOLOGY in 2018: updates and expansion to encompass the new guide to IMMUNOPHARMACOLOGY. PMID:29149325
Gonadotropin regulation by pulsatile GnRH: Signaling and gene expression. PMID:29102564
Prognostic value of ion channel genes in Chinese patients with gliomas based on mRNA expression profiling. PMID:28752501
A three ion channel genes-based signature predicts prognosis of primary glioblastoma patients and reveals a chemotherapy sensitive subtype. PMID:27713134
In silico analysis of the transportome in human pancreatic ductal adenocarcinoma. PMID:27652669
The ICl,swell inhibitor DCPIB blocks Kir channels that possess weak affinity for PIP2. PMID:26837888
Historeceptomic Fingerprints for Drug-Like Compounds. PMID:26733872
ONRLDB--manually curated database of experimentally validated ligands for orphan nuclear receptors: insights into new drug discovery. PMID:26637529
Many InChIs and quite some feat. PMID:26081259
GLASS: a comprehensive database for experimentally validated GPCR-ligand associations. PMID:25971743
Curation and analysis of multitargeting agents for polypharmacological modeling. PMID:25133604
Drug2Gene: an exhaustive resource to explore effectively the drug-target relation network. PMID:24618344
HMPAS: Human Membrane Protein Analysis System. PMID:24564858
Intercellular Lipid Mediators and GPCR Drug Discovery. PMID:24404331
The IUPHAR/BPS Guide to PHARMACOLOGY: an expert-driven knowledgebase of drug targets and their ligands. PMID:24234439
Serotonergic neuron regulation informed by in vivo single-cell transcriptomics. PMID:24192459
Prediction of the P. falciparum target space relevant to malaria drug discovery. PMID:24146604
Paralogue annotation identifies novel pathogenic variants in patients with Brugada syndrome and catecholaminergic polymorphic ventricular tachycardia. PMID:24136861
GPCR ontology: development and application of a G protein-coupled receptor pharmacology knowledge framework. PMID:24078711
Expression profiling of ion channel genes predicts clinical outcome in breast cancer. PMID:24053408
Evolving pharmacology of orphan GPCRs: IUPHAR Commentary. PMID:23957221
How Far Could We Go with Open Data - A Case Study for TRPV1 Antagonists. PMID:23956804
The CARLSBAD database: a confederated database of chemical bioactivities. PMID:23794735
International Union of Basic and Clinical Pharmacology. LXXXVIII. G protein-coupled receptor list: recommendations for new pairings with cognate ligands. PMID:23686350
A comprehensive strategy to identify stoichiometric membrane protein interactomes. PMID:23676845
Cholinergic connectivity: it's implications for psychiatric disorders. PMID:23653591
Biased and constitutive signaling in the CC-chemokine receptor CCR5 by manipulating the interface between transmembrane helices 6 and 7. PMID:23493400
Minireview: ubiquitination-regulated G protein-coupled receptor signaling and trafficking. PMID:23471539
SARConnect: A Tool to Interrogate the Connectivity Between Proteins, Chemical Structures and Activity Data. PMID:23308082
Polypharmacology: drug discovery for the future. PMID:23272792
Gene family matters: expanding the HGNC resource. PMID:23245209
Taking Open Innovation to the Molecular Level - Strengths and Limitations. PMID:23226167
ChemProt-2.0: visual navigation in a disease chemical biology database. PMID:23185041
Potassium channels: a review of broadening therapeutic possibilities for neurological diseases. PMID:23142946
Non-silent story on synonymous sites in voltage-gated ion channel genes. PMID:23119053
IUPHAR-DB: updated database content and new features. PMID:23087376
Functional classification of skeletal muscle networks. I. Normal physiology. PMID:23085959
Inflammatory mediators alter the astrocyte transcriptome and calcium signaling elicited by multiple G-protein-coupled receptors. PMID:23077035
GuideToPharmacology.org--an update. PMID:23003568
Evidence for an interaction of neuronostatin with the orphan G protein-coupled receptor, GPR107. PMID:22933024
5-hydroxytryptamine 2C receptors tonically augment synaptic currents in the nucleus tractus solitarii. PMID:22855775
Cell type specificity of signaling: view from membrane receptors distribution and their downstream transduction networks. PMID:22802048
IUPHAR-DB: an open-access, expert-curated resource for receptor and ion channel research. PMID:22778867
Public domain databases for medicinal chemistry. PMID:22731701
Low affinity GPCRs for metabolic intermediates: challenges for pharmacologists. PMID:22649402
Paralogous annotation of disease-causing variants in long QT syndrome genes. PMID:22581653
Patterned expression of ion channel genes in mouse dorsal raphe nucleus determined with the Allen Mouse Brain Atlas. PMID:22534482
Pharmacology and functions of receptors for vasoactive intestinal peptide and pituitary adenylate cyclase-activating polypeptide: IUPHAR review 1. PMID:22289055
Targeting ion channels for the treatment of gastrointestinal motility disorders. PMID:22282704
Genetic defects in the hotspot of inwardly rectifying K(+) (Kir) channels and their metabolic consequences: a review. PMID:22079268
Open Babel: An open chemical toolbox. PMID:21982300
Mining the ChEMBL database: an efficient chemoinformatics workflow for assembling an ion channel-focused screening library. PMID:21978256
ChEMBL: a large-scale bioactivity database for drug discovery. PMID:21948594
GPCR expression in tissues and cells: are the optimal receptors being used as drug targets? PMID:21488863

https://doi.org/10.1093/nar/gkv1037

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More detailed information about this field from each metasource.

channel
metasource: Fairsharing.org
version: FAIRsharing.org: Guide to Pharmacology; IUPHAR/BPS Guide to PHARMACOLOGY; DOI: https://doi.org/10.25504/FAIRsharing.f1dv0; Last edited: June 22, 2021, 11:57 a.m.; Last accessed: Jan 03 2022 7:06 p.m.

drug interaction
metasource: Fairsharing.org
version: FAIRsharing.org: Guide to Pharmacology; IUPHAR/BPS Guide to PHARMACOLOGY; DOI: https://doi.org/10.25504/FAIRsharing.f1dv0; Last edited: June 22, 2021, 11:57 a.m.; Last accessed: Jan 03 2022 7:06 p.m.

ligand
metasource: Fairsharing.org
version: FAIRsharing.org: Guide to Pharmacology; IUPHAR/BPS Guide to PHARMACOLOGY; DOI: https://doi.org/10.25504/FAIRsharing.f1dv0; Last edited: June 22, 2021, 11:57 a.m.; Last accessed: Jan 03 2022 7:06 p.m.

literature curation
metasource: Fairsharing.org
version: FAIRsharing.org: Guide to Pharmacology; IUPHAR/BPS Guide to PHARMACOLOGY; DOI: https://doi.org/10.25504/FAIRsharing.f1dv0; Last edited: June 22, 2021, 11:57 a.m.; Last accessed: Jan 03 2022 7:06 p.m.

malaria
metasource: Fairsharing.org
version: FAIRsharing.org: Guide to Pharmacology; IUPHAR/BPS Guide to PHARMACOLOGY; DOI: https://doi.org/10.25504/FAIRsharing.f1dv0; Last edited: June 22, 2021, 11:57 a.m.; Last accessed: Jan 03 2022 7:06 p.m.

receptor
metasource: Fairsharing.org
version: FAIRsharing.org: Guide to Pharmacology; IUPHAR/BPS Guide to PHARMACOLOGY; DOI: https://doi.org/10.25504/FAIRsharing.f1dv0; Last edited: June 22, 2021, 11:57 a.m.; Last accessed: Jan 03 2022 7:06 p.m.

target
metasource: Fairsharing.org
version: FAIRsharing.org: Guide to Pharmacology; IUPHAR/BPS Guide to PHARMACOLOGY; DOI: https://doi.org/10.25504/FAIRsharing.f1dv0; Last edited: June 22, 2021, 11:57 a.m.; Last accessed: Jan 03 2022 7:06 p.m.

other molecular biology databases
metasource: Nucleic Acid Research database catalogue
version: extracted_at: 2022-11-04T11:16:25.468657

drugs and drug design
metasource: Nucleic Acid Research database catalogue
version: extracted_at: 2022-11-04T11:16:25.468657

covid-19
metasource: re3data.org
version: re3data.org: IUPHAR/BPS Guide to Pharmacology; editing status 2021-01-12; re3data.org - Registry of Research Data Repositories. http://doi.org/10.17616/R31NJMRG last accessed: 2022-11-04

guide to immunopharmacology
metasource: re3data.org
version: re3data.org: IUPHAR/BPS Guide to Pharmacology; editing status 2021-01-12; re3data.org - Registry of Research Data Repositories. http://doi.org/10.17616/R31NJMRG last accessed: 2022-11-04

guide to malaria pharmacology
metasource: re3data.org
version: re3data.org: IUPHAR/BPS Guide to Pharmacology; editing status 2021-01-12; re3data.org - Registry of Research Data Repositories. http://doi.org/10.17616/R31NJMRG last accessed: 2022-11-04

ligands
metasource: re3data.org
version: re3data.org: IUPHAR/BPS Guide to Pharmacology; editing status 2021-01-12; re3data.org - Registry of Research Data Repositories. http://doi.org/10.17616/R31NJMRG last accessed: 2022-11-04

small molecules
metasource: bio.tools
version: extracted_at: 2022-11-04T11:35:58.708643

model organisms
metasource: bio.tools
version: extracted_at: 2022-11-04T11:35:58.708643

molecular interactions, pathways and networks
metasource: bio.tools
version: extracted_at: 2022-11-04T11:35:58.708643

human biology
metasource: bio.tools
version: extracted_at: 2022-11-04T11:35:58.708643

channel drug interaction ligand literature curation malaria receptor target molecular biology drug covid-19 guide to immunopharmacology guide to malaria pharmacology ligands small molecule model organisms molecular interactions, pathways and networks human

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ChEMBL

Pharmacogenomics Knowledge Base

TTD, Therapeutic Target Database

BPS

Target Pathogen

Reactome - a curated knowledgebase of biological pathways

Diabetes Pharmacology Ontology

Manually Curated Database of Rice Proteins

Open Targets

DrugBank

Drug2Gene

Children’s Kidney Cancers - Great Ormond Street Hospital

GLIDA

BindingDB database of measured binding affinities

The Potential Drug-drug Interaction and Potential Drug-drug Interaction Evidence Ontology

Cyclonet

DrugCentral

UniProt Knowledgebase

SuperTarget

G Protein-Coupled Receptor BioAssays Ontology