DeepHF

Optimized CRISPR guide RNA design for two high-fidelity Cas9 variants by deep learning | Core code for the DeepHF prediction tool | SpCas9 & Base Editor Efficiency Prediction | This tool provides guide designs for Wild-type SpCas9, two highly specific Cas9 mutants(eSpCas9 (1.1) and SpCas9-HF1) and base editors (AncBE4max, ABEmax)

Webpage:

Publications:

Publications

More detailed information about this field from each metasource. ×

Optimized CRISPR guide RNA design for two high-fidelity Cas9 variants by deep learning
PMID: 31537810

metasource: bio.tools
version: extracted_at: 2022-11-04T11:29:32.797430

Close

• Optimized CRISPR guide RNA design for two high-fidelity Cas9 variants by deep learning PubMed citations: 50.

  50 articles citing: Optimized CRISPR guide RNA design for two high-fidelity Cas9 variants by deep learning

  ×

  CNN-XG: A Hybrid Framework for sgRNA On-Target Prediction. PMID:35327601

  ---

  Machine Learning in Healthcare. PMID:35273459

  ---

  Genome-wide functional screens enable the prediction of high activity CRISPR-Cas9 and -Cas12a guides in Yarrowia lipolytica. PMID:35177617

  ---

  Key sequence features of CRISPR RNA for dual-guide CRISPR-Cas9 ribonucleoprotein complexes assembled with wild-type or HiFi Cas9. PMID:35166844

  ---

  High-throughput methods for genome editing: the more the better. PMID:35134245

  ---

  Systematic decomposition of sequence determinants governing CRISPR/Cas9 specificity. PMID:35078987

  ---

  Improved gRNA secondary structures allow editing of target sites resistant to CRISPR-Cas9 cleavage. PMID:35078986

  ---

  AI in health and medicine. PMID:35058619

  ---

  Protein-RNA interaction prediction with deep learning: structure matters. PMID:34929730

  ---

  AttCRISPR: a spacetime interpretable model for prediction of sgRNA on-target activity. PMID:34903170

  ---

  Optimizing sgRNA to Improve CRISPR/Cas9 Knockout Efficiency: Special Focus on Human and Animal Cell. PMID:34869290

  ---

  Uncertainty-aware and interpretable evaluation of Cas9-gRNA and Cas12a-gRNA specificity for fully matched and partially mismatched targets with Deep Kernel Learning. PMID:34791389

  ---

  Neuronal Cell-type Engineering by Transcriptional Activation. PMID:34713262

  ---

  Delivery Platforms for CRISPR/Cas9 Genome Editing of Glial Cells in the Central Nervous System. PMID:34713256

  ---

  An easy-to-use CRISPRi plasmid tool for inducible knockdown in E. coli. PMID:34703773

  ---

  DeepTrio: a ternary prediction system for protein-protein interaction using mask multiple parallel convolutional neural networks. PMID:34694333

  ---

  CRISPR/Cas9 small promoter deletion in H19 lncRNA is associated with altered cell morphology and proliferation. PMID:34526543

  ---

  Understanding the Potential of Genome Editing in Parkinson's Disease. PMID:34502143

  ---

  Genome dependent Cas9/gRNA search time underlies sequence dependent gRNA activity. PMID:34413309

  ---

  TSA Promotes CRISPR/Cas9 Editing Efficiency and Expression of Cell Division-Related Genes from Plant Protoplasts. PMID:34360584

  ---

  Synthetic biology as driver for the biologization of materials sciences. PMID:34195591

  ---

  Gene editing in a Myo6 semi-dominant mouse model rescues auditory function. PMID:34174443

  ---

  Generation of locus-specific degradable tag knock-ins in mouse and human cell lines. PMID:34151298

  ---

  Enhancing CRISPR-Cas9 gRNA efficiency prediction by data integration and deep learning. PMID:34050182

  ---

  Efficient correction of Duchenne muscular dystrophy mutations by SpCas9 and dual gRNAs. PMID:33868784

  ---

  Prediction of CRISPR/Cas9 single guide RNA cleavage efficiency and specificity by attention-based convolutional neural networks. PMID:33841753

  ---

  CRISPR screens in plants: approaches, guidelines, and future prospects. PMID:33823021

  ---

  Genetic Approaches for the Treatment of Facioscapulohumeral Muscular Dystrophy. PMID:33776777

  ---

  Prevention of acquired sensorineural hearing loss in mice by in vivo Htra2 gene editing. PMID:33752742

  ---

  Systematic in vitro specificity profiling reveals nicking defects in natural and engineered CRISPR-Cas9 variants. PMID:33744974

  ---

  Identification of pathogenic variants in cancer genes using base editing screens with editing efficiency correction. PMID:33691754

  ---

  CRISPR-based strategies for targeted transgene knock-in and gene correction. PMID:33659952

  ---

  Highly efficient neuronal gene knockout in vivo by CRISPR-Cas9 via neonatal intracerebroventricular injection of AAV in mice. PMID:33558692

  ---

  A method for characterizing Cas9 variants via a one-million target sequence library of self-targeting sgRNAs. PMID:33450024

  ---

  Genome-scale CRISPR screening at high sensitivity with an empirically designed sgRNA library. PMID:33228647

  ---

  CRISPR-Cas9 genome editing using targeted lipid nanoparticles for cancer therapy. PMID:33208369

  ---

  Base Editing in Human Cells to Produce Single-Nucleotide-Variant Clonal Cell Lines. PMID:33151638

  ---

  dbGuide: a database of functionally validated guide RNAs for genome editing in human and mouse cells. PMID:33051688

  ---

  CRISPR and transposon in vivo screens for cancer drivers and therapeutic targets. PMID:32811551

  ---

  CRISPR/Cas9 in Cancer Immunotherapy: Animal Models and Human Clinical Trials. PMID:32796761

  ---

  A Generative Neural Network for Maximizing Fitness and Diversity of Synthetic DNA and Protein Sequences. PMID:32711843

  ---

  Automated design of a convolutional neural network with multi-scale filters for cost-efficient seismic data classification. PMID:32620867

  ---

  Retinal gene therapy: an eye-opener of the 21st century. PMID:32561864

  ---

  CRISPRpred(SEQ): a sequence-based method for sgRNA on target activity prediction using traditional machine learning. PMID:32487025

  ---

  A Tandem Guide RNA-Based Strategy for Efficient CRISPR Gene Editing of Cell Populations with Low Heterogeneity of Edited Alleles. PMID:32315231

  ---

  CGD: Comprehensive guide designer for CRISPR-Cas systems. PMID:32308928

  ---

  Advances in CRISPR/Cas-based Gene Therapy in Human Genetic Diseases. PMID:32292501

  ---

  Multiplexed CRISPR technologies for gene editing and transcriptional regulation. PMID:32152313

  ---

  Genome Editing for the Understanding and Treatment of Inherited Cardiomyopathies. PMID:31979133

  ---

  Versatile 3' Functionalization of CRISPR Single Guide RNA. PMID:31943634

Tags:

Tags

More detailed information about this field from each metasource. ×

machine learning

metasource: bio.tools
version: extracted_at: 2022-11-04T11:29:32.797430

---

rna

metasource: bio.tools
version: extracted_at: 2022-11-04T11:29:32.797430

---

sequencing

metasource: bio.tools
version: extracted_at: 2022-11-04T11:29:32.797430

Close

rna sequencing