The purpose of this work is to develop an ontology-based framework for developing an information retrieval system to cater to specific queries of users. For creating such an ontology, information was obtained from a wide range of information sources involved with brain tumour study and research. The information thus obtained was compiled and analysed to provide a standard, reliable and relevant information base to aid our proposed system. Facet-based methodology has been used for ontology formalization for quite some time. Ontology formalization involves different steps such as identification of the terminology, analysis, synthesis, standardization and ordering. A vast majority of the ontologies being developed nowadays lack flexibility. This becomes a formidable constraint when it comes to interoperability. We found that a facet-based method provides a distinct guideline for the development of a robust and flexible model concerning the domain of brain tumours. Our attempt has been to bridge library and information science and computer science, which itself involved an experimental approach. It was discovered that a faceted approach is really enduring, as it helps in the achievement of properties like navigation, exploration and faceted browsing. Computer-based brain tumour ontology supports the work of researchers towards gathering information on brain tumour research and allows users across the world to intelligently access new scientific information quickly and efficiently.