Super-Enhancer Archive
Names
More detailed information about this field from each metasource.
Super-Enhancer Archive
metasource: Fairsharing.org
version: FAIRsharing.org: SEA; Super-Enhancer Archive; DOI: https://doi.org/10.25504/FAIRsharing.bya6z; Last edited: March 19, 2021, 12:03 p.m.; Last accessed: Jan 03 2022 7:07 p.m.
SEA
metasource: Fairsharing.org
version: FAIRsharing.org: SEA; Super-Enhancer Archive; DOI: https://doi.org/10.25504/FAIRsharing.bya6z; Last edited: March 19, 2021, 12:03 p.m.; Last accessed: Jan 03 2022 7:07 p.m.
metasource: Nucleic Acid Research database catalogue
version: extracted_at: 2022-11-04T11:16:25.468657
metasource: bio.tools
version: extracted_at: 2022-11-04T11:33:52.883422
sea-archive
metasource: bio.tools
version: extracted_at: 2022-11-04T11:33:52.883422
Names
More detailed information about this field from each metasource.
Super-Enhancer Archive
metasource: Fairsharing.orgversion: FAIRsharing.org: SEA; Super-Enhancer Archive; DOI: https://doi.org/10.25504/FAIRsharing.bya6z; Last edited: March 19, 2021, 12:03 p.m.; Last accessed: Jan 03 2022 7:07 p.m.
SEA
metasource: Fairsharing.orgversion: FAIRsharing.org: SEA; Super-Enhancer Archive; DOI: https://doi.org/10.25504/FAIRsharing.bya6z; Last edited: March 19, 2021, 12:03 p.m.; Last accessed: Jan 03 2022 7:07 p.m.
metasource: Nucleic Acid Research database catalogue
version: extracted_at: 2022-11-04T11:16:25.468657
metasource: bio.tools
version: extracted_at: 2022-11-04T11:33:52.883422
sea-archive
metasource: bio.toolsversion: extracted_at: 2022-11-04T11:33:52.883422
Names
More detailed information about this field from each metasource.
Super-Enhancer Archive
metasource: Fairsharing.orgversion: FAIRsharing.org: SEA; Super-Enhancer Archive; DOI: https://doi.org/10.25504/FAIRsharing.bya6z; Last edited: March 19, 2021, 12:03 p.m.; Last accessed: Jan 03 2022 7:07 p.m.
SEA
metasource: Fairsharing.orgversion: FAIRsharing.org: SEA; Super-Enhancer Archive; DOI: https://doi.org/10.25504/FAIRsharing.bya6z; Last edited: March 19, 2021, 12:03 p.m.; Last accessed: Jan 03 2022 7:07 p.m.
metasource: Nucleic Acid Research database catalogue
version: extracted_at: 2022-11-04T11:16:25.468657
metasource: bio.tools
version: extracted_at: 2022-11-04T11:33:52.883422
sea-archive
metasource: bio.toolsversion: extracted_at: 2022-11-04T11:33:52.883422
SEA (Super-Enhancer Archive) is a web-based comprehensive resource focusing on the collection, storage and online analysis of super-enhancers. It focuses on integrating super-enhancers in multiple species and annotating their potential roles in the regulation of cell identity gene expression. To facilitate data extraction, SEA supports multiple search options, including species, genome location, gene name, cell type/tissue, and super-enhancer name.
Description
More detailed information about this field from each metasource.
SEA (Super-Enhancer Archive) is a web-based comprehensive resource focusing on the collection, storage and online analysis of super-enhancers. It focuses on integrating super-enhancers in multiple species and annotating their potential roles in the regulation of cell identity gene expression. To facilitate data extraction, SEA supports multiple search options, including species, genome location, gene name, cell type/tissue, and super-enhancer name.
metasource: Fairsharing.orgversion: FAIRsharing.org: SEA; Super-Enhancer Archive; DOI: https://doi.org/10.25504/FAIRsharing.bya6z; Last edited: March 19, 2021, 12:03 p.m.; Last accessed: Jan 03 2022 7:07 p.m.
SEA (Super-Enhancer Archive, http://sea.edbc.org/) is a web based comprehensive resource focuses on the collection, storage and online analysis of super-enhancers. It focuses on integrating super-enhancers in multiple species and annotating their potential roles in the regulation of cell identity gene expression. The current release of SEA incorporates 83,996 super-enhancers computationally or experimentally identified in 134 cell types/tissues/diseases, including human (75,439, three of which were experimentally identified), mouse (5,879, five of which were experimentally identified), Drosophila melanogaster (1,774), and Caenorhabditis elegans (904). To facilitate data extraction, SEA supports multiple search options, including species, genome location, gene name, cell type/tissue, and super-enhancer name. The response provides detailed (epi)genetic information, incorporating cell type specificity, nearby genes, transcriptional factor binding sites, CRISPR-Cas9 target sites, evolutionary conservation, SNPs, H3K27ac, DNA methylation, gene expression, and TF ChIP-seq data. Moreover, analytical tools and a genome browser were developed for users to explore super-enhancers and their roles in defining cell identity and disease processes in depth.
metasource: Nucleic Acid Research database catalogueversion: extracted_at: 2022-11-04T11:16:25.468657
Super-Enhancer Archive. Integrates super-enhancers in multiple species and annotates their potential roles in the regulation of cell identity gene expression.
metasource: bio.toolsversion: extracted_at: 2022-11-04T11:33:52.883422
Webpage:
http://sea.edbc.org/Webpage
More detailed information about this field from each metasource.
http://sea.edbc.org/
metasource: Fairsharing.orgversion: FAIRsharing.org: SEA; Super-Enhancer Archive; DOI: https://doi.org/10.25504/FAIRsharing.bya6z; Last edited: March 19, 2021, 12:03 p.m.; Last accessed: Jan 03 2022 7:07 p.m.
http://sea.edbc.org
metasource: Nucleic Acid Research database catalogueversion: extracted_at: 2022-11-04T11:16:25.468657
metasource: bio.tools
version: extracted_at: 2022-11-04T11:33:52.883422
Publications:
Publications
More detailed information about this field from each metasource.
SEA: a super-enhancer archive
PMID: 26578594
metasource: Fairsharing.org
version: FAIRsharing.org: SEA; Super-Enhancer Archive; DOI: https://doi.org/10.25504/FAIRsharing.bya6z; Last edited: March 19, 2021, 12:03 p.m.; Last accessed: Jan 03 2022 7:07 p.m.
metasource: bio.tools
version: extracted_at: 2022-11-04T11:33:52.883422
http://dx.doi.org/10.1093/nar/gkv1243
metasource: Nucleic Acid Research database catalogue
version: extracted_at: 2022-11-04T11:16:25.468657
Publications
More detailed information about this field from each metasource.
SEA: a super-enhancer archive
PMID: 26578594
metasource: Fairsharing.org
version: FAIRsharing.org: SEA; Super-Enhancer Archive; DOI: https://doi.org/10.25504/FAIRsharing.bya6z; Last edited: March 19, 2021, 12:03 p.m.; Last accessed: Jan 03 2022 7:07 p.m.
metasource: bio.tools
version: extracted_at: 2022-11-04T11:33:52.883422
http://dx.doi.org/10.1093/nar/gkv1243
metasource: Nucleic Acid Research database catalogueversion: extracted_at: 2022-11-04T11:16:25.468657
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SEA: a super-enhancer archive
PubMed citations: 55.
55 articles citing: SEA: a super-enhancer archive
Analysis of the landscape of human enhancer sequences in biological databases. PMID:35685360
Whole exome sequencing identifies novel germline variants of SLC15A4 gene as potentially cancer predisposing in familial colorectal cancer. PMID:35562597
PCRMS: a database of predicted cis-regulatory modules and constituent transcription factor binding sites in genomes. PMID:35452518
A Comparative Analysis of Super-Enhancers and Broad H3K4me3 Domains in Pig, Human, and Mouse Tissues. PMID:34899824
Seeing the forest through the trees: prioritising potentially functional interactions from Hi-C. PMID:34454581
Whole Exome Sequencing Identifies APCDD1 and HDAC5 Genes as Potentially Cancer Predisposing in Familial Colorectal Cancer. PMID:33673279
Super enhancers-Functional cores under the 3D genome. PMID:33336467
Super-enhancer in prostate cancer: transcriptional disorders and therapeutic targets. PMID:33299103
The emerging role of super enhancer-derived noncoding RNAs in human cancer. PMID:33042269
Characterization of super-enhancer-associated functional lncRNAs acting as ceRNAs in ESCC. PMID:32460441
Integrated Epigenome, Exome, and Transcriptome Analyses Reveal Molecular Subtypes and Homeotic Transformation in Uterine Fibroids. PMID:31851934
EnhancerAtlas 2.0: an updated resource with enhancer annotation in 586 tissue/cell types across nine species. PMID:31740966
Super-enhancers in transcriptional regulation and genome organization. PMID:31724731
Identification of gene specific cis-regulatory elements during differentiation of mouse embryonic stem cells: An integrative approach using high-throughput datasets. PMID:31682597
SEA version 3.0: a comprehensive extension and update of the Super-Enhancer archive. PMID:31667506
An enhancer cluster controls gene activity and topology of the SCN5A-SCN10A locus in vivo. PMID:31666509
ENdb: a manually curated database of experimentally supported enhancers for human and mouse. PMID:31665430
Whole Genome Sequencing of Familial Non-Medullary Thyroid Cancer Identifies Germline Alterations in MAPK/ERK and PI3K/AKT Signaling Pathways. PMID:31614935
Beyond the Exome: The Non-coding Genome and Enhancers in Neurodevelopmental Disorders and Malformations of Cortical Development. PMID:31417368
SEanalysis: a web tool for super-enhancer associated regulatory analysis. PMID:31028388
PLAIDOH: a novel method for functional prediction of long non-coding RNAs identifies cancer-specific LncRNA activities. PMID:30767760
Modeling double strand break susceptibility to interrogate structural variation in cancer. PMID:30736820
EnhancerDB: a resource of transcriptional regulation in the context of enhancers. PMID:30689845
RAEdb: a database of enhancers identified by high-throughput reporter assays. PMID:30624654
Interpreting Non-coding Genetic Variation in Multiple Sclerosis Genome-Wide Associated Regions. PMID:30619471
Isolation and genome-wide characterization of cellular DNA:RNA triplex structures. PMID:30605520
OncoBase: a platform for decoding regulatory somatic mutations in human cancers. PMID:30445567
SEdb: a comprehensive human super-enhancer database. PMID:30371817
Knockdown of RAI14 suppresses the progression of gastric cancer. PMID:30349303
High-salt-recovered sequences are associated with the active chromosomal compartment and with large ribonucleoprotein complexes including nuclear bodies. PMID:30287550
HACER: an atlas of human active enhancers to interpret regulatory variants. PMID:30247654
Transcriptional targeting of oncogene addiction in medullary thyroid cancer. PMID:30135308
Super-enhancers maintain renin-expressing cell identity and memory to preserve multi-system homeostasis. PMID:30130256
Familial Cancer Variant Prioritization Pipeline version 2 (FCVPPv2) applied to a papillary thyroid cancer family. PMID:30072699
Engineering the Drosophila Genome for Developmental Biology. PMID:29615571
Stratification of TAD boundaries reveals preferential insulation of super-enhancers by strong boundaries. PMID:29416042
BRD4 interacts with NIPBL and BRD4 is mutated in a Cornelia de Lange-like syndrome. PMID:29379197
Structure and function of the Nppa-Nppb cluster locus during heart development and disease. PMID:29302701
HEDD: Human Enhancer Disease Database. PMID:29077884
DiseaseEnhancer: a resource of human disease-associated enhancer catalog. PMID:29059320
dbCoRC: a database of core transcriptional regulatory circuitries modeled by H3K27ac ChIP-seq signals. PMID:28977473
Direct targets of pSTAT5 signalling in erythropoiesis. PMID:28732065
Clinical study of genomic drivers in pancreatic ductal adenocarcinoma. PMID:28720843
LDB1-mediated enhancer looping can be established independent of mediator and cohesin. PMID:28520978
Orphan CpG islands define a novel class of highly active enhancers. PMID:28448736
Integrated genomic analyses reveal frequent TERT aberrations in acral melanoma. PMID:28373299
Functional Enhancers As Master Regulators of Tissue-Specific Gene Regulation and Cancer Development. PMID:28359147
Epigenetic and genetic dissections of UV-induced global gene dysregulation in skin cells through multi-omics analyses. PMID:28211524
A somatic-mutational process recurrently duplicates germline susceptibility loci and tissue-specific super-enhancers in breast cancers. PMID:28112740
Molecular mechanisms underlying noncoding risk variations in psychiatric genetic studies. PMID:28044063
DNA Hypomethylation in Intragenic and Intergenic Enhancer Chromatin of Muscle-Specific Genes Usually Correlates with their Expression. PMID:28018137
Comparative analyses of super-enhancers reveal conserved elements in vertebrate genomes. PMID:27965291
Complex cis-regulatory landscape of the insulin receptor gene underlies the broad expression of a central signaling regulator. PMID:27702787
LMethyR-SVM: Predict Human Enhancers Using Low Methylated Regions based on Weighted Support Vector Machines. PMID:27662487
The 2016 database issue of Nucleic Acids Research and an updated molecular biology database collection. PMID:26740669 - http://dx.doi.org/10.1093/nar/gkv1243
Tags:
Tags
More detailed information about this field from each metasource.
chromatin immunoprecipitation - dna sequencing
metasource: Fairsharing.org
version: FAIRsharing.org: SEA; Super-Enhancer Archive; DOI: https://doi.org/10.25504/FAIRsharing.bya6z; Last edited: March 19, 2021, 12:03 p.m.; Last accessed: Jan 03 2022 7:07 p.m.
enhancer
metasource: Fairsharing.org
version: FAIRsharing.org: SEA; Super-Enhancer Archive; DOI: https://doi.org/10.25504/FAIRsharing.bya6z; Last edited: March 19, 2021, 12:03 p.m.; Last accessed: Jan 03 2022 7:07 p.m.
regulation of gene expression
metasource: Fairsharing.org
version: FAIRsharing.org: SEA; Super-Enhancer Archive; DOI: https://doi.org/10.25504/FAIRsharing.bya6z; Last edited: March 19, 2021, 12:03 p.m.; Last accessed: Jan 03 2022 7:07 p.m.
taxonomic classification
metasource: Fairsharing.org
version: FAIRsharing.org: SEA; Super-Enhancer Archive; DOI: https://doi.org/10.25504/FAIRsharing.bya6z; Last edited: March 19, 2021, 12:03 p.m.; Last accessed: Jan 03 2022 7:07 p.m.
transcription factor
metasource: Fairsharing.org
version: FAIRsharing.org: SEA; Super-Enhancer Archive; DOI: https://doi.org/10.25504/FAIRsharing.bya6z; Last edited: March 19, 2021, 12:03 p.m.; Last accessed: Jan 03 2022 7:07 p.m.
nucleotide sequence databases
metasource: Nucleic Acid Research database catalogue
version: extracted_at: 2022-11-04T11:16:25.468657
transcriptional regulator sites and transcription factors
metasource: Nucleic Acid Research database catalogue
version: extracted_at: 2022-11-04T11:16:25.468657
transcription factors and regulatory sites
metasource: bio.tools
version: extracted_at: 2022-11-04T11:33:52.883422
epigenetics
metasource: bio.tools
version: extracted_at: 2022-11-04T11:33:52.883422
Tags
More detailed information about this field from each metasource.
chromatin immunoprecipitation - dna sequencing
metasource: Fairsharing.orgversion: FAIRsharing.org: SEA; Super-Enhancer Archive; DOI: https://doi.org/10.25504/FAIRsharing.bya6z; Last edited: March 19, 2021, 12:03 p.m.; Last accessed: Jan 03 2022 7:07 p.m.
enhancer
metasource: Fairsharing.orgversion: FAIRsharing.org: SEA; Super-Enhancer Archive; DOI: https://doi.org/10.25504/FAIRsharing.bya6z; Last edited: March 19, 2021, 12:03 p.m.; Last accessed: Jan 03 2022 7:07 p.m.
regulation of gene expression
metasource: Fairsharing.orgversion: FAIRsharing.org: SEA; Super-Enhancer Archive; DOI: https://doi.org/10.25504/FAIRsharing.bya6z; Last edited: March 19, 2021, 12:03 p.m.; Last accessed: Jan 03 2022 7:07 p.m.
taxonomic classification
metasource: Fairsharing.orgversion: FAIRsharing.org: SEA; Super-Enhancer Archive; DOI: https://doi.org/10.25504/FAIRsharing.bya6z; Last edited: March 19, 2021, 12:03 p.m.; Last accessed: Jan 03 2022 7:07 p.m.
transcription factor
metasource: Fairsharing.orgversion: FAIRsharing.org: SEA; Super-Enhancer Archive; DOI: https://doi.org/10.25504/FAIRsharing.bya6z; Last edited: March 19, 2021, 12:03 p.m.; Last accessed: Jan 03 2022 7:07 p.m.
nucleotide sequence databases
metasource: Nucleic Acid Research database catalogueversion: extracted_at: 2022-11-04T11:16:25.468657
transcriptional regulator sites and transcription factors
metasource: Nucleic Acid Research database catalogueversion: extracted_at: 2022-11-04T11:16:25.468657
transcription factors and regulatory sites
metasource: bio.toolsversion: extracted_at: 2022-11-04T11:33:52.883422
epigenetics
metasource: bio.toolsversion: extracted_at: 2022-11-04T11:33:52.883422
chromatin immunoprecipitation - dna sequencing enhancer regulation of gene expression taxonomic classification transcription nucleic acid sequence transcription transcription factors and regulatory sites epigenetics
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