S/MARt DB
The nuclear organization of metaphase and interphase cells has been studied over several decades and increasing evidence supports the concept upon which the eukaryotic chromatin is organized in the form of functional independent loop domains [1; 2]. Scaffold/matrix attached regions (S/MARs) are DNA sequences that mediate the tight contact of the chromatin with the proteinaceous scaffold within the nucleus. They have shown to be necessary for chromatin loops to form [3] and they were observed at the base of chromatin loops [4]. S/MARs have also been assigned to function in gene expression. Recently it has been shown that S/MARs can serve as landing platforms for several chromatin remodeling factors and thereby influence gene expression [5]. S/MARs were also attributed a fundamental role in carcinogenesis [6]. S/MARt DB is a curated database which collects information about S/MARs and nuclear proteins which are involved in the interaction of these elements with the nuclear scaffold [7]. Its wet-lab verified data are compiled predominantly from publications in peer-reviewed journals. The database equipped with tools for searching and browsing is freely accessible through WWW (http://smartdb.bioinf.med.uni-goettingen.de/) for users from non-profit organizations. The data presented as three hyperlinked files for the use via the internet come mainly from animal and plant species. S/MARt DB has been enlarged by new entries to 500 S/MAR entries in the recent release and improved further by updating of already existing entries in each of its tables. With release 2.2 the database was complemented by hyperlinks to EntrezGene and Ensembl, respectively. They serve to incorporate S/MARt DB into a European network of biological databases which is going to be build up in the context of the TEMBLOR project.
Description
More detailed information about this field from each metasource.
The nuclear organization of metaphase and interphase cells has been studied over several decades and increasing evidence supports the concept upon which the eukaryotic chromatin is organized in the form of functional independent loop domains [1; 2]. Scaffold/matrix attached regions (S/MARs) are DNA sequences that mediate the tight contact of the chromatin with the proteinaceous scaffold within the nucleus. They have shown to be necessary for chromatin loops to form [3] and they were observed at the base of chromatin loops [4]. S/MARs have also been assigned to function in gene expression. Recently it has been shown that S/MARs can serve as landing platforms for several chromatin remodeling factors and thereby influence gene expression [5]. S/MARs were also attributed a fundamental role in carcinogenesis [6]. S/MARt DB is a curated database which collects information about S/MARs and nuclear proteins which are involved in the interaction of these elements with the nuclear scaffold [7]. Its wet-lab verified data are compiled predominantly from publications in peer-reviewed journals. The database equipped with tools for searching and browsing is freely accessible through WWW (http://smartdb.bioinf.med.uni-goettingen.de/) for users from non-profit organizations. The data presented as three hyperlinked files for the use via the internet come mainly from animal and plant species. S/MARt DB has been enlarged by new entries to 500 S/MAR entries in the recent release and improved further by updating of already existing entries in each of its tables. With release 2.2 the database was complemented by hyperlinks to EntrezGene and Ensembl, respectively. They serve to incorporate S/MARt DB into a European network of biological databases which is going to be build up in the context of the TEMBLOR project.
metasource: Nucleic Acid Research database catalogueversion: extracted_at: 2022-11-04T11:16:25.468657
Webpage:
http://smartdb.bioinf.med.uni-goettingen.de/Webpage
More detailed information about this field from each metasource.
http://smartdb.bioinf.med.uni-goettingen.de/
metasource: Nucleic Acid Research database catalogueversion: extracted_at: 2022-11-04T11:16:25.468657
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nucleotide sequence databases
metasource: Nucleic Acid Research database catalogue
version: extracted_at: 2022-11-04T11:16:25.468657
coding and non-coding dna
metasource: Nucleic Acid Research database catalogue
version: extracted_at: 2022-11-04T11:16:25.468657
Tags
More detailed information about this field from each metasource.
nucleotide sequence databases
metasource: Nucleic Acid Research database catalogueversion: extracted_at: 2022-11-04T11:16:25.468657
coding and non-coding dna
metasource: Nucleic Acid Research database catalogueversion: extracted_at: 2022-11-04T11:16:25.468657
nucleic acid sequence coding and non-coding dna
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