FAIRsharing.nm2z1h; Last edited: Feb. 10, 2020, 5:13 p.m.; Last accessed: Jan 03 2022 7:08 p.m.

Other names: PDBePISA

The Protein Quaternary Structure file server (PDBePISA) is an internet resource that makes available coordinates for likely quaternary states for structures contained in the Brookhaven Protein Data Bank (PDB) that were determined by X-ray crystallography.

Webpage:

http://www.ebi.ac.uk/pdbe/pqs/

Licence:

Name: Open Data Commons (ODC) Public Domain Dedication and Licence (PDDL) 1.0
URL: http://opendatacommons.org/licenses/pddl/1.0/

Publications:

Publications
More detailed information about this field from each metasource.

Inference of macromolecular assemblies from crystalline state
PMID: 17681537
metasource: Fairsharing.org
version: FAIRsharing.org: PDBePISA; Protein Data Bank: Proteins, Interfaces, Structures and Assemblies; DOI: https://doi.org/10.25504/FAIRsharing.nm2z1h; Last edited: Feb. 10, 2020, 5:13 p.m.; Last accessed: Jan 03 2022 7:08 p.m.

PQS: a protein quaternary structure file server
PMID: 9787643
metasource: Fairsharing.org
version: FAIRsharing.org: PDBePISA; Protein Data Bank: Proteins, Interfaces, Structures and Assemblies; DOI: https://doi.org/10.25504/FAIRsharing.nm2z1h; Last edited: Feb. 10, 2020, 5:13 p.m.; Last accessed: Jan 03 2022 7:08 p.m.

Inference of macromolecular assemblies from crystalline state PubMed citations: 4459.

4459 articles citing: Inference of macromolecular assemblies from crystalline state

Structural and mechanistic analysis of a tripartite ATP-independent periplasmic TRAP transporter. PMID:35927235
Architecture and self-assembly of the jumbo bacteriophage nuclear shell. PMID:35922510
Identification of IOMA-class neutralizing antibodies targeting the CD4-binding site on the HIV-1 envelope glycoprotein. PMID:35922441
Molecular and in vivo studies of a glutamate-class prolyl-endopeptidase for coeliac disease therapy. PMID:35915115
Structural determinants of DNA recognition by the NO sensor NsrR and related Rrf2-type [FeS]-transcription factors. PMID:35908109
Human antibodies to SARS-CoV-2 with a recurring YYDRxG motif retain binding and neutralization to variants of concern including Omicron. PMID:35906394
De novo determination of mosquitocidal Cry11Aa and Cry11Ba structures from naturally-occurring nanocrystals. PMID:35902572
In Silico Designed Multi-Epitope Immunogen "Tpme-VAC/LGCM-2022" May Induce Both Cellular and Humoral Immunity against Treponema pallidum Infection. PMID:35891183
Structural and mechanistic insights into the cleavage of clustered O-glycan patches-containing glycoproteins by mucinases of the human gut. PMID:35882872
Necroptosis-Mediated eCIRP Release in Sepsis. PMID:35873387
Rep15 interacts with several Rab GTPases and has a distinct fold for a Rab effector. PMID:35871249
The two-domain elevator-type mechanism of zinc-transporting ZIP proteins. PMID:35857505
Omicron Binding Mode: Contact Analysis and Dynamics of the Omicron Receptor-Binding Domain in Complex with ACE2. PMID:35849759
Biochemical and Structural Characterization of Thermostable GH159 Glycoside Hydrolases Exhibiting α-L-Arabinofuranosidase Activity. PMID:35847984
Allosteric Hotspots in the Main Protease of SARS-CoV-2. PMID:35843284
Vaccine-elicited murine antibody WS6 neutralizes diverse beta-coronaviruses by recognizing a helical stem supersite of vulnerability. PMID:35841885
A monomeric mycobacteriophage immunity repressor utilizes two domains to recognize an asymmetric DNA sequence. PMID:35835745
In silico analysis of SARS-CoV-2 spike protein N501Y and N501T mutation effects on human ACE2 binding. PMID:35809511
The nuclear egress complex of Epstein-Barr virus buds membranes through an oligomerization-driven mechanism. PMID:35802751
Structural and functional characterization of DdrC, a novel DNA damage-induced nucleoid associated protein involved in DNA compaction. PMID:35801857
Human IgE monoclonal antibody recognition of mite allergen Der p 2 defines structural basis of an epitope for IgE cross-linking and anaphylaxis in vivo. PMID:35799831
Cryo-EM structure of acylpeptide hydrolase reveals substrate selection by multimerization and a multi-state serine-protease triad. PMID:35799812
Mechanistic insights into the rational design of masked antibodies. PMID:35799328
A panel of nanobodies recognizing conserved hidden clefts of all SARS-CoV-2 spike variants including Omicron. PMID:35794202
Discovery of archaeal fusexins homologous to eukaryotic HAP2/GCS1 gamete fusion proteins. PMID:35794124
Identification, structure determination and analysis of Mycobacterium smegmatis acyl-carrier protein synthase (AcpS) crystallized serendipitously. PMID:35787552
Crystal structure of the BREX phage defence protein BrxA. PMID:35783086
Molecular dissection of the glutamine synthetase-GlnR nitrogen regulatory circuitry in Gram-positive bacteria. PMID:35778410
Recognition of the TDP-43 nuclear localization signal by importin α1/β. PMID:35767952
A broad and potent neutralization epitope in SARS-related coronaviruses. PMID:35767670
Identification of 2-(4-N,N-Dimethylaminophenyl)-5-methyl-1-phenethyl-1H-benzimidazole targeting HIV-1 CA capsid protein and inhibiting HIV-1 replication in cellulo. PMID:35765101
Evolution and activation mechanism of the flavivirus class II membrane-fusion machinery. PMID:35764616
Evolution of homo-oligomerization of methionine S-adenosyltransferases is replete with structure-function constrains. PMID:35762725
LAG3 ectodomain structure reveals functional interfaces for ligand and antibody recognition. PMID:35761082
Mapping paratopes of nanobodies using native mass spectrometry and ultraviolet photodissociation. PMID:35756525
Structural basis of the IL-1 receptor TIR domain-mediated IL-1 signaling. PMID:35754719
Structure-based electron-confurcation mechanism of the Ldh-EtfAB complex. PMID:35748623
Genome-Wide Identification of m6A Writers, Erasers and Readers in Poplar 84K. PMID:35741780
Metal cofactor stabilization by a partner protein is a widespread strategy employed for amidase activation. PMID:35733252
Cryo-EM structure of a type IV secretion system. PMID:35732732
Studies on the antiviral activity of chebulinic acid against dengue and chikungunya viruses and in silico investigation of its mechanism of inhibition. PMID:35729191
An M protein coiled coil unfurls and exposes its hydrophobic core to capture LL-37. PMID:35726694
Structural Characterization of a Neutralizing Nanobody With Broad Activity Against SARS-CoV-2 Variants. PMID:35722331
Structural variations between small alarmone hydrolase dimers support different modes of regulation of the stringent response. PMID:35714769
Proteome-Wide and Protein-Specific Multi-Epitope Vaccine Constructs Against the Rift Valley Fever Virus Outbreak Using Integrated Omics Approaches. PMID:35711778
Crystal Structure of an Intramolecular Mesaconyl-Coenzyme A Transferase From the 3-Hydroxypropionic Acid Cycle of Roseiflexus castenholzii. PMID:35711761
Structural insights into the lysophospholipid brain uptake mechanism and its inhibition by syncytin-2. PMID:35710838
Competition for dominance within replicating quasispecies during prolonged SARS-CoV-2 infection in an immunocompromised host. PMID:35706980
Potent human broadly SARS-CoV-2-neutralizing IgA and IgG antibodies effective against Omicron BA.1 and BA.2. PMID:35704748
Brachypodium Antifreeze Protein Gene Products Inhibit Ice Recrystallisation, Attenuate Ice Nucleation, and Reduce Immune Response. PMID:35684248
A single sensor controls large variations in zinc quotas in a marine cyanobacterium. PMID:35681030
Dynamic interplay between the periplasmic chaperone SurA and the BAM complex in outer membrane protein folding. PMID:35676411
The structure of EXTL3 helps to explain the different roles of bi-domain exostosins in heparan sulfate synthesis. PMID:35676258
High-affinity anti-Arc nanobodies provide tools for structural and functional studies. PMID:35671319
In silico SARS-CoV-2 vaccine development for Omicron strain using reverse vaccinology. PMID:35665465
Potent cross-reactive antibodies following Omicron breakthrough in vaccinees. PMID:35662412
Direct interaction of a chaperone-bound type III secretion substrate with the export gate. PMID:35654781
Pentameric assembly of the Kv2.1 tetramerization domain. PMID:35647925
Structural basis of human LRG1 recognition by Magacizumab, a humanized monoclonal antibody with therapeutic potential. PMID:35647920
Crystal structure of thermally stable homodimeric cytochrome c'-β from Thermus thermophilus. PMID:35647678
Cryo-EM structures of human A2ML1 elucidate the protease-inhibitory mechanism of the A2M family. PMID:35641520
Structure of the glucosyltransferase domain of TcdA in complex with RhoA provides insights into substrate recognition. PMID:35637242
Complex Mutation Pattern of Omicron BA.2: Evading Antibodies without Losing Receptor Interactions. PMID:35628343
Clade-Specific Alterations within the HIV-1 Capsid Protein with Implications for Nuclear Translocation. PMID:35625621
Large-Size Subunit Catalases Are Chimeric Proteins: A H2O2 Selecting Domain with Catalase Activity Fused to a Hsp31-Derived Domain Conferring Protein Stability and Chaperone Activity. PMID:35624843
The ArsH Protein Product of the Paracoccus denitrificans ars Operon Has an Activity of Organoarsenic Reductase and Is Regulated by a Redox-Responsive Repressor. PMID:35624766
The Structure of Bilirubin Oxidase from Bacillus pumilus Reveals a Unique Disulfide Bond for Site-Specific Direct Electron Transfer. PMID:35624560
Antigenic structure of the human coronavirus OC43 spike reveals exposed and occluded neutralizing epitopes. PMID:35614127
In silico design and analyses of a multi-epitope vaccine against Crimean-Congo hemorrhagic fever virus through reverse vaccinology and immunoinformatics approaches. PMID:35610299
Structural comparisons reveal diverse binding modes between nucleosome assembly proteins and histones. PMID:35606827
Ancient plant-like terpene biosynthesis in corals. PMID:35606558
Crystal structure of Arabidopsis thaliana HPPK/DHPS, a bifunctional enzyme and target of the herbicide asulam. PMID:35605193
Glycyrrhetinic acid restricts mitochondrial energy metabolism by targeting SHMT2. PMID:35602963
Structural characterization of a cross-protective natural chimera of factor H binding protein from meningococcal serogroup B strain NL096. PMID:35601959
Biophysical Insight into the SARS-CoV2 Spike-ACE2 Interaction and Its Modulation by Hepcidin through a Multifaceted Computational Approach. PMID:35600142
A truncated anti-CRISPR protein prevents spacer acquisition but not interference. PMID:35589712
Structure of the IL-27 quaternary receptor signaling complex. PMID:35579417
A nucleotide-sensing oligomerization mechanism that controls NrdR-dependent transcription of ribonucleotide reductases. PMID:35577776
Multiple-Allele MHC Class II Epitope Engineering by a Molecular Dynamics-Based Evolution Protocol. PMID:35572587
Metal-Induced Fluorescence Quenching of Photoconvertible Fluorescent Protein DendFP. PMID:35566273
Reverse Engineering Analysis of the High-Temperature Reversible Oligomerization and Amyloidogenicity of PSD95-PDZ3. PMID:35566161
Kunitz-Type Peptides from Sea Anemones Protect Neuronal Cells against Parkinson's Disease Inductors via Inhibition of ROS Production and ATP-Induced P2X7 Receptor Activation. PMID:35563513
Functional and Structural Diversity of Bacterial Contact-Dependent Growth Inhibition Effectors. PMID:35558562
Structural insights of a highly potent pan-neutralizing SARS-CoV-2 human monoclonal antibody. PMID:35549549
Structural basis of sodium-dependent bile salt uptake into the liver. PMID:35545671
Novel super-neutralizing antibody UT28K is capable of protecting against infection from a wide variety of SARS-CoV-2 variants. PMID:35543180
A structural dissection of protein-RNA interactions based on different RNA base areas of interfaces. PMID:35540439
Structural, mechanistic, and physiological insights into phospholipase A-mediated membrane phospholipid degradation in Pseudomonas aeruginosa. PMID:35536643
Phenol-soluble modulins PSMα3 and PSMβ2 form nanotubes that are cross-α amyloids. PMID:35533283
Designing a novel E2-IFN-γ fusion protein against CSFV by immunoinformatics and structural vaccinology approaches. PMID:35524776
Optimization of IL-1RA structure to achieve a smaller protein with a higher affinity to its receptor. PMID:35523814
Improved therapeutic efficacy of quercetin-loaded polymeric nanoparticles on triple-negative breast cancer by inhibiting uPA. PMID:35514369
The mechanism of activation of MEK1 by B-Raf and KSR1. PMID:35508574
Structural insights into choline-O-sulfatase reveal the molecular determinants for ligand binding. PMID:35503214
The structure of Phocaeicola vulgatus sialic acid acetylesterase. PMID:35503212
Structure and role of the linker domain of the iron surface-determinant protein IsdH in heme transportation in Staphylococcus aureus. PMID:35500652
SARS-CoV-2 pan-variant inhibitory peptides deter S1-ACE2 interaction and neutralize delta and omicron pseudoviruses. PMID:35495107
T54R mutation destabilizes the dimer of superoxide dismutase 1T54R by inducing steric clashes at the dimer interface. PMID:35492906
Human IgG1 Fc pH-dependent optimization from a constant pH molecular dynamics simulation analysis. PMID:35492131
Structure of an influenza group 2-neutralizing antibody targeting the hemagglutinin stem supersite. PMID:35489332
Molecular basis of antibiotic self-resistance in a bee larvae pathogen. PMID:35487884
Structural Insight into Molecular Inhibitory Mechanism of InsP6 on African Swine Fever Virus mRNA-Decapping Enzyme g5Rp. PMID:35481780
Structural and functional characterization of TrmM in m6 A modification of bacterial tRNA. PMID:35481631
USP14-regulated allostery of the human proteasome by time-resolved cryo-EM. PMID:35477760
L-tyrosine-bound ThiH structure reveals C-C bond break differences within radical SAM aromatic amino acid lyases. PMID:35477710
An ACE2-blocking antibody confers broad neutralization and protection against Omicron and other SARS-CoV-2 variants of concern. PMID:35471062
An engineered protein-based submicromolar competitive inhibitor of the Staphylococcus aureus virulence factor aureolysin. PMID:35465156
Structural Basis of Human Dimeric α-Amino-β-Carboxymuconate-ε-Semialdehyde Decarboxylase Inhibition With TES-1025. PMID:35463964
Autopromotion of K-Ras4B Feedback Activation Through an SOS-Mediated Long-Range Allosteric Effect. PMID:35463958
Isolation, characterization, and structure-based engineering of a neutralizing nanobody against SARS-CoV-2. PMID:35460753
Anti-SARS-CoV-2 potential of Cissampelos pareira L. identified by connectivity map-based analysis and in vitro studies. PMID:35459166
Molecular Organisation of Tick-Borne Encephalitis Virus. PMID:35458522
Structural Insight into KsBcl-2 Mediated Apoptosis Inhibition by Kaposi Sarcoma Associated Herpes Virus. PMID:35458468
Antibody recognition of complement factor H reveals a flexible loop involved in atypical hemolytic uremic syndrome pathogenesis. PMID:35452676
Structural basis for C-type inactivation in a Shaker family voltage-gated K+ channel. PMID:35452285
Analysis of memory B cells identifies conserved neutralizing epitopes on the N-terminal domain of variant SARS-Cov-2 spike proteins. PMID:35447092
Mechanism of RNA polymerase I selection by transcription factor UAF. PMID:35442737
Broadly neutralizing antibodies target the coronavirus fusion peptide. PMID:35441178
An antibody class with a common CDRH3 motif broadly neutralizes sarbecoviruses. PMID:35438546
Residual Structure in the Denatured State of the Fast-Folding UBA(1) Domain from the Human DNA Excision Repair Protein HHR23A. PMID:35430812
Deciphering the structure of Arabidopsis thaliana 5-enol-pyruvyl-shikimate-3-phosphate synthase: An essential step toward the discovery of novel inhibitors to supersede glyphosate. PMID:35422967
Active Release of eCIRP via Gasdermin D Channels to Induce Inflammation in Sepsis. PMID:35418465
Identification and Tetramer Structure of Hemin-Binding Protein SPD_0310 Linked to Iron Homeostasis and Virulence of Streptococcus pneumoniae. PMID:35414267
ComFC mediates transport and handling of single-stranded DNA during natural transformation. PMID:35414142
Structural basis for llama nanobody recognition and neutralization of HIV-1 at the CD4-binding site. PMID:35413243
CPR-C4 is a highly conserved novel protease from the Candidate Phyla Radiation with remote structural homology to human vasohibins. PMID:35405098
The structure of Synechococcus elongatus enolase reveals key aspects of phosphoenolpyruvate binding. PMID:35400670
Crystal structure of the ternary complex of Leishmania major pteridine reductase 1 with the cofactor NADP+/NADPH and the substrate folic acid. PMID:35400669
Structure of BrxA from Staphylococcus aureus, a bacilliredoxin involved in redox homeostasis in Firmicutes. PMID:35400666
Structural basis of human IL-18 sequestration by the decoy receptor IL-18 binding protein in inflammation and tumor immunity. PMID:35398099
Structural characterization of the homotropic cooperative binding of azamulin to human cytochrome P450 3A5. PMID:35398097
Mechanism of proteasome gate modulation by assembly chaperones Pba1 and Pba2. PMID:35398095
A large-scale systematic survey reveals recurring molecular features of public antibody responses to SARS-CoV-2. PMID:35397794
The biosynthetic origin of ribofuranose in bacterial polysaccharides. PMID:35393575
Panel of Engineered Ubiquitin Variants Targeting the Family of Human Ubiquitin Interacting Motifs. PMID:35385646
Structural and biochemical characterisation of the Providencia stuartii arginine decarboxylase shows distinct polymerisation and regulation. PMID:35383285
Directed Evolution-Driven Increase of Structural Plasticity Is a Prerequisite for Binding the Complement Lectin Pathway Blocking MASP-Inhibitor Peptides. PMID:35378038
High-resolution structures of malaria parasite actomyosin and actin filaments. PMID:35377914
Conformational plasticity of the HIV-1 gp41 immunodominant region is recognized by multiple non-neutralizing antibodies. PMID:35361878
Cryo-EM structures of staphylococcal IsdB bound to human hemoglobin reveal the process of heme extraction. PMID:35357971
A CNN model for predicting binding affinity changes between SARS-CoV-2 spike RBD variants and ACE2 homologues. PMID:35350198
Mouse and human antibodies bind HLA-E-leader peptide complexes and enhance NK cell cytotoxicity. PMID:35347236
Molecular basis of specificity and deamidation of eIF4A by Burkholderia Lethal Factor 1. PMID:35347220
Crystal structure report of the ImmR transcriptional regulator DNA-binding domain of the Bacillus subtilis ICEBs1 transposon. PMID:35347179
Substrate-binding loop interactions with pseudouridine trigger conformational changes that promote catalytic efficiency of pseudouridine kinase PUKI. PMID:35346685
Acquired Disorder and Asymmetry in a Domain-Swapped Model for γ-Crystallin Aggregation. PMID:35341744
Structural and molecular rationale for the diversification of resistance mediated by the Antibiotic_NAT family. PMID:35338238
Structural basis of SARM1 activation, substrate recognition, and inhibition by small molecules. PMID:35334231
Double drugging of prolyl-tRNA synthetase provides a new paradigm for anti-infective drug development. PMID:35333915
Glutathione binding to the plant AtAtm3 transporter and implications for the conformational coupling of ABC transporters. PMID:35333177
The mRubyFT Protein, Genetically Encoded Blue-to-Red Fluorescent Timer. PMID:35328628
The Family Keeps on Growing: Four Novel Fungal OYEs Characterized. PMID:35328465
SARS-CoV-2 Membrane Protein: From Genomic Data to Structural New Insights. PMID:35328409
Contrasting Modes of New World Arenavirus Neutralization by Immunization-Elicited Monoclonal Antibodies. PMID:35315691
A broad and potent neutralization epitope in SARS-related coronaviruses. PMID:35313576
Structures of a deltacoronavirus spike protein bound to porcine and human receptors. PMID:35304871
Mechanism of Borrelia immune evasion by FhbA-related proteins. PMID:35303742
Flagellin outer domain dimerization modulates motility in pathogenic and soil bacteria from viscous environments. PMID:35301306
The Structure of the Arabidopsis PEX4-PEX22 Peroxin Complex-Insights Into Ubiquitination at the Peroxisomal Membrane. PMID:35300425
Canavanine resistance mutation can1-1 in Schizosaccharomyces pombe is a missense mutation in the ubiquitin ligase adaptor gene any1. PMID:35300005
Computational Evolution Protocol for Peptide Design. PMID:35298821
Structure and conformational dynamics of Clostridioides difficile toxin A. PMID:35292538
Structure of the poxvirus decapping enzyme D9 reveals its mechanism of cap recognition and catalysis. PMID:35290794
Nebulized delivery of a broadly neutralizing SARS-CoV-2 RBD-specific nanobody prevents clinical, virological, and pathological disease in a Syrian hamster model of COVID-19. PMID:35289719
Structure and activity of the DHNA Coenzyme-A Thioesterase from Staphylococcus aureus providing insights for innovative drug development. PMID:35279696
Cryo-EM Structure of a Kinetically Trapped Dodecameric Portal Protein from the Pseudomonas-phage PaP3. PMID:35278476
Atomic structure of the predominant GII.4 human norovirus capsid reveals novel stability and plasticity. PMID:35273142
Structure of a Janus kinase cytokine receptor complex reveals the basis for dimeric activation. PMID:35271300
Investigating the Effects of Amino Acid Variations in Human Menin. PMID:35268848
Enzymatic and structural characterization of β-fructofuranosidase from the honeybee gut bacterium Frischella perrara. PMID:35267055
Differential recognition of canonical NF-κB dimers by Importin α3. PMID:35260573
How clustered protocadherin binding specificity is tuned for neuronal self-/nonself-recognition. PMID:35253643
Ubiquitin and a charged loop regulate the ubiquitin E3 ligase activity of Ark2C. PMID:35246518
Mechanism of cooperative N-glycan processing by the multi-modular endoglycosidase EndoE. PMID:35241669
A multi-factor trafficking site on the spliceosome remodeling enzyme BRR2 recruits C9ORF78 to regulate alternative splicing. PMID:35241646
A new inactive conformation of SARS-CoV-2 main protease. PMID:35234150
A recurring packing contact in crystals of InlB pinpoints functional binding sites in the internalin domain and the B repeat. PMID:35234145
Insights on the mutational landscape of the SARS-CoV-2 Omicron variant receptor-binding domain. PMID:35233548
Molecular basis of receptor binding and antibody neutralization of Omicron. PMID:35228716
Inhibitory Effects of Bacterial Silk-like Biopolymer on Herpes Simplex Virus Type 1, Adenovirus Type 7 and Hepatitis C Virus Infection. PMID:35225980
A mechanism of origin licensing control through autoinhibition of S. cerevisiae ORC·DNA·Cdc6. PMID:35217664
Structure and assembly of the S-layer in C. difficile. PMID:35217634
Heterodimer of A2A and Oxytocin Receptors Regulating Glutamate Release in Adult Striatal Astrocytes. PMID:35216441
Computational Design of Single-Peptide Nanocages with Nanoparticle Templating. PMID:35209027
The structure of the Clostridium thermocellum RsgI9 ectodomain provides insight into the mechanism of biomass sensing. PMID:35194841
The intrinsically disordered TSSC4 protein acts as a helicase inhibitor, placeholder and multi-interaction coordinator during snRNP assembly and recycling. PMID:35188580
Impact of distant peptide substrate residues on enzymatic activity of SlyD. PMID:35184231
The endoplasmic reticulum proteostasis network profoundly shapes the protein sequence space accessible to HIV envelope. PMID:35180219
Cryo-EM structures reveal high-resolution mechanism of a DNA polymerase sliding clamp loader. PMID:35179493
Visualizing protein breathing motions associated with aromatic ring flipping. PMID:35173330
Cryo-EM structure of the SARS-CoV-2 Omicron spike. PMID:35172173
Structural basis for SARS-CoV-2 Delta variant recognition of ACE2 receptor and broadly neutralizing antibodies. PMID:35169135
Effects of Myristate on the Induced Circular Dichroism Spectra of Aripiprazole Bound to Human Serum Albumin: A Structural-Chemical Investigation. PMID:35155934
PSTPIP1-LYP phosphatase interaction: structural basis and implications for autoinflammatory disorders. PMID:35152348
Structural characterization of the Myxococcus xanthus encapsulin and ferritin-like cargo system gives insight into its iron storage mechanism. PMID:35150605
Structural characterization of the ANTAR antiterminator domain bound to RNA. PMID:35150565
Role of PemI in the Staphylococcus aureus PemIK toxin-antitoxin complex: PemI controls PemK by acting as a PemK loop mimic. PMID:35141752
Omicron: A Heavily Mutated SARS-CoV-2 Variant Exhibits Stronger Binding to ACE2 and Potently Escapes Approved COVID-19 Therapeutic Antibodies. PMID:35140714
Surface Ig variable domain glycosylation affects autoantigen binding and acts as threshold for human autoreactive B cell activation. PMID:35138894
Barcode fusion genetics-protein-fragment complementation assay (BFG-PCA): tools and resources that expand the potential for binary protein interaction discovery. PMID:35137167
Neutralizing antibodies induced in immunized macaques recognize the CD4-binding site on an occluded-open HIV-1 envelope trimer. PMID:35136084
Tousled-like kinase 2 targets ASF1 histone chaperones through client mimicry. PMID:35136069
A human antibody reveals a conserved site on beta-coronavirus spike proteins and confers protection against SARS-CoV-2 infection. PMID:35133175
Conserved Neutralizing Epitopes on the N-Terminal Domain of Variant SARS-CoV-2 Spike Proteins. PMID:35132412
An archaellum filament composed of two alternating subunits. PMID:35132062
Unusual substrate specificity in GH family 12: structure-function analysis of glucanases Bgh12A and Xgh12B from Aspergillus cervinus, and Egh12 from Thielavia terrestris. PMID:35129654
D155Y substitution of SARS-CoV-2 ORF3a weakens binding with Caveolin-1. PMID:35126886
A Fc-enhanced NTD-binding non-neutralizing antibody delays virus spread and synergizes with a nAb to protect mice from lethal SARS-CoV-2 infection. PMID:35123652
Structure of the NLRP3 decamer bound to the cytokine release inhibitor CRID3. PMID:35114687
Rapid identification of neutralizing antibodies against SARS-CoV-2 variants by mRNA display. PMID:35114110
Structurally-discovered KLF4 variants accelerate and stabilize reprogramming to pluripotency. PMID:35106457
PplD is a de-N-acetylase of the cell wall linkage unit of streptococcal rhamnopolysaccharides. PMID:35105886
Mechanisms of Cre recombinase synaptic complex assembly and activation illuminated by Cryo-EM. PMID:35104890
Crystal structure and initial characterization of a novel archaeal-like Holliday junction-resolving enzyme from Thermus thermophilus phage Tth15-6. PMID:35102887
Teneurin4 dimer structures reveal a calcium-stabilized compact conformation supporting homomeric trans-interactions. PMID:35099835
Structural and functional characterization of a monoclonal antibody blocking TIGIT. PMID:35090381
From complete cross-docking to partners identification and binding sites predictions. PMID:35089918
Structural basis for safe and efficient energy conversion in a respiratory supercomplex. PMID:35087070
SARS-CoV-2 Omicron-B.1.1.529 leads to widespread escape from neutralizing antibody responses. PMID:35081335
Antibodies to Cartilage Oligomeric Matrix Protein Are Pathogenic in Mice and May Be Clinically Relevant in Rheumatoid Arthritis. PMID:35080151
Structure of the human ATM kinase and mechanism of Nbs1 binding. PMID:35076389
SARS-CoV-2 Beta variant infection elicits potent lineage-specific and cross-reactive antibodies. PMID:35076281
QSalignWeb: A Server to Predict and Analyze Protein Quaternary Structure. PMID:35071324
Characterization and structural analyses of a novel glycosyltransferase acting on the β-1,2-glucosidic linkages. PMID:35065074
A Structural Perspective of Reps from CRESS-DNA Viruses and Their Bacterial Plasmid Homologues. PMID:35062241
Subsite Ligand Recognition and Cooperativity in the TPP Riboswitch: Implications for Fragment-Linking in RNA Ligand Discovery. PMID:35060698
Analysis of 272 Genetic Variants in the Upgraded Interactive FXI Web Database Reveals New Insights into FXI Deficiency. PMID:35059554
The Structure and Immune Regulatory Implications of the Ubiquitin-Like Tandem Domain Within an Avian 2'-5' Oligoadenylate Synthetase-Like Protein. PMID:35058932
Interfacial Peptides as Affinity Modulating Agents of Protein-Protein Interactions. PMID:35053254
A Model for Allosteric Communication in Drug Transport by the AcrAB-TolC Tripartite Efflux Pump. PMID:35052929
Thermal Stability and Inhibitory Action of Red Grape Skin Phytochemicals against Enzymes Associated with Metabolic Syndrome. PMID:35052624
The Mysterious Multitude: Structural Perspective on the Accessory Subunits of Respiratory Complex I. PMID:35047558
Structural Basis of Antibody Conformation and Stability Modulation by Framework Somatic Hypermutation. PMID:35046963
An infectious SARS-CoV-2 B.1.1.529 Omicron virus escapes neutralization by therapeutic monoclonal antibodies. PMID:35046573
The Species-Specific 282 Residue in the PB2 Subunit of the Polymerase Regulates RNA Synthesis and Replication of Influenza A Viruses Infecting Bat and Nonbat Hosts. PMID:35044213
Structural basis of cyclic oligoadenylate binding to the transcription factor Csa3 outlines cross talk between type III and type I CRISPR systems. PMID:35038453
Structure and function of a family of tick-derived complement inhibitors targeting properdin. PMID:35031611
Rewards of divergence in sequences, 3-D structures and dynamics of yeast and human spliceosome SF3b complexes. PMID:35028595
Structural basis of Plasmodium vivax inhibition by antibodies binding to the circumsporozoite protein repeats. PMID:35023832
Cross-linking mass spectrometry reveals structural insights of the glutamine synthetase from Leishmania braziliensis. PMID:35019070
A small RNA that cooperatively senses two stacked metabolites in one pocket for gene control. PMID:35017488
IMPDH1 retinal variants control filament architecture to tune allosteric regulation. PMID:35013599
A bispecific monomeric nanobody induces spike trimer dimers and neutralizes SARS-CoV-2 in vivo. PMID:35013189
Purification, Characterization, and Structural Studies of a Sulfatase from Pedobacter yulinensis. PMID:35011319
Integrative Study of the Structural and Dynamical Properties of a KirBac3.1 Mutant: Functional Implication of a Highly Conserved Tryptophan in the Transmembrane Domain. PMID:35008764
Inhibition of Tau seeding by targeting Tau nucleation core within neurons with a single domain antibody fragment. PMID:35007758
Structural basis for the multimerization of nonstructural protein nsp9 from SARS-CoV-2. PMID:35006420
Structural characterization of the C-terminal domain of SARS-CoV-2 nucleocapsid protein. PMID:35006385
Molecular Basis of Selective Cytokine Signaling Inhibition by Antibodies Targeting a Shared Receptor. PMID:35003094
Observation of robust energy transfer in the photosynthetic protein allophycocyanin using single-molecule pump-probe spectroscopy. PMID:34992285
Protection of the Prodomain α1-Helix Correlates with Latency in the Transforming Growth Factor-β Family. PMID:34990654
Structures and therapeutic potential of anti-RBD human monoclonal antibodies against SARS-CoV-2. PMID:34987630
The crystal structure of DynF from the dynemicin-biosynthesis pathway of Micromonospora chersina. PMID:34981769
Catalytically active holo Homo sapiens adenosine deaminase I adopts a closed conformation. PMID:34981765
Omicron-B.1.1.529 leads to widespread escape from neutralizing antibody responses. PMID:34981049
An infectious SARS-CoV-2 B.1.1.529 Omicron virus escapes neutralization by therapeutic monoclonal antibodies. PMID:34981042
Solution NMR and racemic crystallography provide insights into a novel structural class of cyclic plant peptides. PMID:34977583
Development of a potent high-affinity human therapeutic antibody via novel application of recombination signal sequence-based affinity maturation. PMID:34973336
Structural basis and mode of action for two broadly neutralizing antibodies against SARS-CoV-2 emerging variants of concern. PMID:34971573
Members of the vertebrate contactin and amyloid precursor protein families interact through a conserved interface. PMID:34958801
High-valency Anti-CD99 Antibodies Toward the Treatment of T Cell Acute Lymphoblastic Leukemia. PMID:34958778
Structural Insight into the Mechanism of PALB2 Interaction with MRG15. PMID:34946951
Structural Characterization of Rat Galectin-5, an N-Tailed Monomeric Proto-Type-like Galectin. PMID:34944498
Radioprotective Role of Vitamins C and E against the Gamma Ray-Induced Damage to the Chemical Structure of Bovine Serum Albumin. PMID:34942979
Structural basis of malaria transmission blockade by a monoclonal antibody to gamete fusogen HAP2. PMID:34939934
Exosome-Mediated eCIRP Release From Macrophages to Induce Inflammation in Sepsis. PMID:34938194
A Peptide Derived from GAPDH Enhances Resistance to DNA Damage in Saccharomyces cerevisiae Cells. PMID:34936834
Cryo-EM structure of the autoinhibited state of myosin-2. PMID:34936462
Epitope Mapping with Diethylpyrocarbonate Covalent Labeling-Mass Spectrometry. PMID:34932327
Conformational dynamics of the Beta and Kappa SARS-CoV-2 spike proteins and their complexes with ACE2 receptor revealed by cryo-EM. PMID:34930910
The antibody response to SARS-CoV-2 Beta underscores the antigenic distance to other variants. PMID:34921776
Oxidative stress protein Oxr1 promotes V-ATPase holoenzyme disassembly in catalytic activity-independent manner. PMID:34918374
Insights on the mutational landscape of the SARS-CoV-2 Omicron variant. PMID:34909771
CPVT-associated calmodulin variants N53I and A102V dysregulate Ca2+ signalling via different mechanisms. PMID:34888671
Structural and molecular basis for Cardiovirus 2A protein as a viral gene expression switch. PMID:34887415
Hedgehog-Interacting Protein is a multimodal antagonist of Hedgehog signalling. PMID:34887403
LSSmScarlet, dCyRFP2s, dCyOFP2s and CRISPRed2s, Genetically Encoded Red Fluorescent Proteins with a Large Stokes Shift. PMID:34884694
Perception of structurally distinct effectors by the integrated WRKY domain of a plant immune receptor. PMID:34880132
GTP binding to translation factor eIF2B stimulates its guanine nucleotide exchange activity. PMID:34877508
Next generation Fc scaffold for multispecific antibodies. PMID:34877503
A large-scale systematic survey of SARS-CoV-2 antibodies reveals recurring molecular features. PMID:34873599
Neurotoxin-mediated potent activation of the axon degeneration regulator SARM1. PMID:34870595
The Structural Biology of Septins and Their Filaments: An Update. PMID:34869357
Structure, Function and Regulation of a Second Pyruvate Kinase Isozyme in Pseudomonas aeruginosa. PMID:34867929
The X-ray structure of juvenile hormone diol kinase from the silkworm Bombyx mori. PMID:34866602
DeepRank: a deep learning framework for data mining 3D protein-protein interfaces. PMID:34862392
NLRP3 cages revealed by full-length mouse NLRP3 structure control pathway activation. PMID:34861190
Catalytic flexibility of rice glycosyltransferase OsUGT91C1 for the production of palatable steviol glycosides. PMID:34857750
Conformational changes in Lassa virus L protein associated with promoter binding and RNA synthesis activity. PMID:34857749
Discovery of an exosite on the SOCS2-SH2 domain that enhances SH2 binding to phosphorylated ligands. PMID:34857742
Chromosome segregation in Archaea: SegA- and SegB-DNA complex structures provide insights into segrosome assembly. PMID:34850144
Structure and in silico simulations of a cold-active esterase reveals its prime cold-adaptation mechanism. PMID:34847772
B0AT1 Amino Acid Transporter Complexed With SARS-CoV-2 Receptor ACE2 Forms a Heterodimer Functional Unit: In Situ Conformation Using Radiation Inactivation Analysis. PMID:34847569
Engineered ACE2-Fc counters murine lethal SARS-CoV-2 infection through direct neutralization and Fc-effector activities. PMID:34845451
A monoclonal antibody that neutralizes SARS-CoV-2 variants, SARS-CoV, and other sarbecoviruses. PMID:34836485
Structural Biology of Nanobodies against the Spike Protein of SARS-CoV-2. PMID:34835020
A Structural Overview of Vascular Endothelial Growth Factors Pharmacological Ligands: From Macromolecules to Designed Peptidomimetics. PMID:34833851
Mechanisms of CP190 Interaction with Architectural Proteins in Drosophila Melanogaster. PMID:34830280
A structured RNA motif locks Argonaute2:miR-122 onto the 5' end of the HCV genome. PMID:34824224
The human microbiome encodes resistance to the antidiabetic drug acarbose. PMID:34819672
High-resolution structure of native toxin A from Clostridioides difficile. PMID:34817920
Human RIPK3 maintains MLKL in an inactive conformation prior to cell death by necroptosis. PMID:34811356
Mutation-Induced Long-Range Allosteric Interactions in the Spike Protein Determine the Infectivity of SARS-CoV-2 Emerging Variants. PMID:34805715
Molecular basis of dimerization of lytic transglycosylase revealed by the crystal structure of MltA from Acinetobacter baumannii. PMID:34804545
Crystal structure of the pheromone Er-13 from the ciliate Euplotes raikovi, with implications for a protein-protein association model in pheromone/receptor interactions. PMID:34800649
Molecular insights into substrate recognition and catalysis by phthalate dioxygenase from Comamonas testosteroni. PMID:34800435
Exploring the mechanism of Yixinyin for myocardial infarction by weighted co-expression network and molecular docking. PMID:34799616
Crystal structures of the elusive Rhizobium etli L-asparaginase reveal a peculiar active site. PMID:34795296
Comparative genomic analysis reveals varying levels of mammalian adaptation to coronavirus infections. PMID:34793437
Nebulized delivery of a broadly neutralizing SARS-CoV-2 RBD-specific nanobody prevents clinical, virological and pathological disease in a Syrian hamster model of COVID-19. PMID:34790977
Structural insights into Ubr1-mediated N-degron polyubiquitination. PMID:34789879
Protein-Protein Docking: Past, Present, and Future. PMID:34787783
A Bacterial Cell-Based Assay To Study SARS-CoV-2 Protein-Protein Interactions. PMID:34781739
Structural basis for the multimerization of nonstructural protein nsp9 from SARS-CoV-2. PMID:34765992
Structural characterization of the C-terminal domain of SARS-CoV-2 nucleocapsid protein. PMID:34765991
Scaffolding protein CcmM directs multiprotein phase separation in β-carboxysome biogenesis. PMID:34759380
A Structural Basis for Inhibition of the Complement Initiator Protease C1r by Lyme Disease Spirochetes. PMID:34759015
A single amino acid polymorphism in a conserved effector of the multihost blast fungus pathogen expands host-target binding spectrum. PMID:34758051
Structurally Mapping Antigenic Epitopes of Adeno-associated Virus 9: Development of Antibody Escape Variants. PMID:34757842
A site of vulnerability at V3 crown defined by HIV-1 bNAb M4008_N1. PMID:34753944
Investigating molecular mechanisms of 2A-stimulated ribosomal pausing and frameshifting in Theilovirus. PMID:34751406
The minimal structure for iodotyrosine deiodinase function is defined by an outlier protein from the thermophilic bacterium Thermotoga neapolitana. PMID:34748729
Computational redesign of a fluorogen activating protein with Rosetta. PMID:34748541
Structural insights into kinetoplastid coronin oligomerization domain and F-actin interaction. PMID:34746809
Structural basis of glycan276-dependent recognition by HIV-1 broadly neutralizing antibodies. PMID:34731616
Surface-induced Dissociation Mass Spectrometry as a Structural Biology Tool. PMID:34726898
Constant pH molecular dynamics of porcine circovirus 2 capsid protein reveals a mechanism for capsid assembly. PMID:34726674
Crystal structure of the [2Fe-2S] protein I (Shethna protein I) from Azotobacter vinelandii. PMID:34726179
Structural basis for SdgB- and SdgA-mediated glycosylation of staphylococcal adhesive proteins. PMID:34726173
Neutralizing Antibodies to SARS-CoV-2 Selected from a Human Antibody Library Constructed Decades Ago. PMID:34716683
Non-conventional octameric structure of C-phycocyanin. PMID:34716405
Vascular KATP channel structural dynamics reveal regulatory mechanism by Mg-nucleotides. PMID:34711681
The structure of neurofibromin isoform 2 reveals different functional states. PMID:34707296
Dispatched uses Na+ flux to power release of lipid-modified Hedgehog. PMID:34707294
Cryo-EM structure of the needle filament tip complex of the Salmonella type III secretion injectisome. PMID:34706941
Neutralizing antibody 5-7 defines a distinct site of vulnerability in SARS-CoV-2 spike N-terminal domain. PMID:34706271
Optimisation of Neuraminidase Expression for Use in Drug Discovery by Using HEK293-6E Cells. PMID:34696326
Structure of a human replisome shows the organisation and interactions of a DNA replication machine. PMID:34694004
Elevated expression of MKRN3 in squamous cell carcinoma of the head and neck and its clinical significance. PMID:34689784
Naturally occurring cancer-associated mutations disrupt oligomerization and activity of protein arginine methyltransferase 1 (PRMT1). PMID:34688662
Identification of difructose dianhydride I synthase/hydrolase from an oral bacterium establishes a novel glycoside hydrolase family. PMID:34688653
First Crystal Structure of Bacterial Oligopeptidase B in an Intermediate State: The Roles of the Hinge Region Modification and Spermine. PMID:34681120
Mutually Exclusive Expression of Closely Related Odorant-Binding Proteins 9A and 9B in the Antenna of the Red Flour Beetle Tribolium castaneum. PMID:34680135
Full Neutralization of Centruroidessculpturatus Scorpion Venom by Combining Two Human Antibody Fragments. PMID:34679001
Uncovering a conserved vulnerability site in SARS-CoV-2 by a human antibody. PMID:34672091
An Atypical Autoinflammatory Disease Due to an LRR Domain NLRP3 Mutation Enhancing Binding to NEK7. PMID:34671876
A monoclonal antibody that neutralizes SARS-CoV-2 variants, SARS-CoV, and other sarbecoviruses. PMID:34671769
The inner mechanics of rhodopsin guanylyl cyclase during cGMP-formation revealed by real-time FTIR spectroscopy. PMID:34665128
Small molecule interactions with the SARS-CoV-2 main protease: In silico all-atom microsecond MD simulations, PELE Monte Carlo simulations, and determination of in vitro activity inhibition. PMID:34655918
Large-scale movement of eIF3 domains during translation initiation modulate start codon selection. PMID:34648019
The novel anti-CRISPR AcrIIA22 relieves DNA torsion in target plasmids and impairs SpyCas9 activity. PMID:34644300
Exosite Binding in Thrombin: A Global Structural/Dynamic Overview of Complexes with Aptamers and Other Ligands. PMID:34639143
Trop2 Forms a Stable Dimer with Significant Structural Differences within the Membrane-Distal Region as Compared to EpCAM. PMID:34638982
A Novel Lipase from Lasiodiplodia theobromae Efficiently Hydrolyses C8-C10 Methyl Esters for the Preparation of Medium-Chain Triglycerides' Precursors. PMID:34638680
Weaving of bacterial cellulose by the Bcs secretion systems. PMID:34634120
3D Domain Swapping Dimerization of the Receiver Domain of Cytokinin Receptor CRE1 From Arabidopsis thaliana and Medicago truncatula. PMID:34630499
The tertiary structure of the human Xkr8-Basigin complex that scrambles phospholipids at plasma membranes. PMID:34625749
The structural basis of PTEN regulation by multi-site phosphorylation. PMID:34625746
Catalytic and structural insights into a stereospecific and thermostable Class II aldolase HpaI from Acinetobacter baumannii. PMID:34624314
Exceptionally potent human monoclonal antibodies are effective for prophylaxis and treatment of tetanus in mice. PMID:34618682
Zoonotic potential of a novel bat morbillivirus. PMID:34611656
Molecular switches regulating the potency and immune evasiveness of SARS-CoV-2 spike protein. PMID:34611654
Landscape of human antibody recognition of the SARS-CoV-2 receptor binding domain. PMID:34610292
Retinal pigment epithelium 65 kDa protein (RPE65): An update. PMID:34607013
Systematic Evaluation of Fluorination as Modification for Peptide-Based Fusion Inhibitors against HIV-1 Infection. PMID:34605595
Structural characterization of human peptidyl-arginine deiminase type III by X-ray crystallography. PMID:34605437
Intermolecular latency regulates the essential C-terminal signal peptidase and sortase of the Porphyromonas gingivalis type-IX secretion system. PMID:34593635
Network theory reveals principles of spliceosome structure and dynamics. PMID:34592160
A systematic bioinformatics approach for large-scale identification and characterization of host-pathogen shared sequences. PMID:34583643
A lipoprotein allosterically activates the CwlD amidase during Clostridioides difficile spore formation. PMID:34570752
Auxiliary interfaces support the evolution of specific toxin-antitoxin pairing. PMID:34556858
Structure of a Ty1 restriction factor reveals the molecular basis of transposition copy number control. PMID:34552077
Improved pathogenicity prediction for rare human missense variants. PMID:34551312
Capsid Structure of Anabaena Cyanophage A-1(L). PMID:34549983
Association of the malate dehydrogenase-citrate synthase metabolon is modulated by intermediates of the Krebs tricarboxylic acid cycle. PMID:34548590
The hypervariable region of atlastin-1 is a site for intrinsic and extrinsic regulation. PMID:34546351
Peptides Targeting the Interaction Between Erb1 and Ytm1 Ribosome Assembly Factors. PMID:34540895
Structural basis of RNA polymerase inhibition by viral and host factors. PMID:34535646
Broad cross-reactivity across sarbecoviruses exhibited by a subset of COVID-19 donor-derived neutralizing antibodies. PMID:34534459
Structural characterization of NrnC identifies unifying features of dinucleotidases. PMID:34533457
The ongoing evolution of variants of concern and interest of SARS-CoV-2 in Brazil revealed by convergent indels in the amino (N)-terminal domain of the spike protein. PMID:34532067
PDB-wide identification of physiological hetero-oligomeric assemblies based on conserved quaternary structure geometry. PMID:34520740
Bispecific antibodies targeting distinct regions of the spike protein potently neutralize SARS-CoV-2 variants of concern. PMID:34519517
Regulation of human mTOR complexes by DEPTOR. PMID:34519268
Novel quaternary structures of the human prion protein globular domain. PMID:34517052
A SARS-CoV-2 antibody broadly neutralizes SARS-related coronaviruses and variants by coordinated recognition of a virus-vulnerable site. PMID:34508662
Phosphopantetheinyl transferase binding and inhibition by amidino-urea and hydroxypyrimidinethione compounds. PMID:34508141
Profiling CD8+ T cell epitopes of COVID-19 convalescents reveals reduced cellular immune responses to SARS-CoV-2 variants. PMID:34506741
Structural basis for membrane recruitment of ATG16L1 by WIPI2 in autophagy. PMID:34505572
Focal accumulation of aromaticity at the CDRH3 loop mitigates 4E10 polyreactivity without altering its HIV neutralization profile. PMID:34505005
In vivo pharmacokinetic enhancement of monomeric Fc and monovalent bispecific designs through structural guidance. PMID:34497355
Understanding the molecular interaction of SARS-CoV-2 spike mutants with ACE2 (angiotensin converting enzyme 2). PMID:34495817
Structure of the native pyruvate dehydrogenase complex reveals the mechanism of substrate insertion. PMID:34489474
Conformational dynamics linked to domain closure and substrate binding explain the ERAP1 allosteric regulation mechanism. PMID:34489420
A potently neutralizing SARS-CoV-2 antibody inhibits variants of concern by utilizing unique binding residues in a highly conserved epitope. PMID:34481543
Calmodulin extracts the Ras family protein RalA from lipid bilayers by engagement with two membrane-targeting motifs. PMID:34480001
Glycogen phosphorylase revisited: extending the resolution of the R- and T-state structures of the free enzyme and in complex with allosteric activators. PMID:34473107
Complex structure of the acyltransferase VinK and the carrier protein VinL with a pantetheine cross-linking probe. PMID:34473106
Structural and biochemical characterization of the novel serpin Iripin-5 from Ixodes ricinus. PMID:34473088
Multiple Signals in the Gut Contract the Mouse Norovirus Capsid To Block Antibody Binding While Enhancing Receptor Affinity. PMID:34468172
SNX27-FERM-SNX1 complex structure rationalizes divergent trafficking pathways by SNX17 and SNX27. PMID:34462354
High-resolution structure of the amino acid transporter AdiC reveals insights into the role of water molecules and networks in oligomerization and substrate binding. PMID:34461897
Conformational changes in tubulin upon binding cryptophycin-52 reveal its mechanism of action. PMID:34461087
Structures of heat shock factor trimers bound to DNA. PMID:34458700
DNA Aptamers Block the Receptor Binding Domain at the Spike Protein of SARS-CoV-2. PMID:34458322
The Repressor C Protein, Pf4r, Controls Superinfection of Pseudomonas aeruginosa PAO1 by the Pf4 Filamentous Phage and Regulates Host Gene Expression. PMID:34452479
Crystal Structure of a Retroviral Polyprotein: Prototype Foamy Virus Protease-Reverse Transcriptase (PR-RT). PMID:34452360
Binding Properties of Photosynthetic Herbicides with the QB Site of the D1 Protein in Plant Photosystem II: A Combined Functional and Molecular Docking Study. PMID:34451546
Native structure of the RhopH complex, a key determinant of malaria parasite nutrient acquisition. PMID:34446549
Modeling and Structure Determination of Homo-Oligomeric Proteins: An Overview of Challenges and Current Approaches. PMID:34445785
Structural Basis of Inhibition of DCLK1 by Ruxolitinib. PMID:34445192
The Uncommon Active Site of D-Amino Acid Transaminase from Haliscomenobacter hydrossis: Biochemical and Structural Insights into the New Enzyme. PMID:34443642
Structural Dissection of Viral Spike-Protein Binding of SARS-CoV-2 and SARS-CoV-1 to the Human Angiotensin-Converting Enzyme 2 (ACE2) as Cellular Receptor. PMID:34440241
BusR senses bipartite DNA binding motifs by a unique molecular ruler architecture. PMID:34432045
Ankyrin repeats in context with human population variation. PMID:34428215
Unfolding Mechanisms and Conformational Stability of the Dimeric Endophilin N-BAR Domain. PMID:34423187
Biochemical and Structural Characterisation of a Novel D-Lyxose Isomerase From the Hyperthermophilic Archaeon Thermofilum sp. PMID:34422783
Improved epitope resolution of the prefusion trimer-specific antibody AM14 bound to the RSV F glycoprotein. PMID:34420474
UbiD domain dynamics underpins aromatic decarboxylation. PMID:34417452
Structures of a deAMPylation complex rationalise the switch between antagonistic catalytic activities of FICD. PMID:34408154
Rapid selection of HIV envelopes that bind to neutralizing antibody B cell lineage members with functional improbable mutations. PMID:34407396
Insights into the structure and RNA-binding specificity of Caenorhabditis elegans Dicer-related helicase 3 (DRH-3). PMID:34403472
Crystal structure of the INTS3/INTS6 complex reveals the functional importance of INTS3 dimerization in DSB repair. PMID:34400606
The PilB-PilZ-FimX regulatory complex of the Type IV pilus from Xanthomonas citri. PMID:34398935
X-shaped structure of bacterial heterotetrameric tRNA synthetase suggests cryptic prokaryote functions and a rationale for synthetase classifications. PMID:34390350
Perturbation of ACE2 Structural Ensembles by SARS-CoV-2 Spike Protein Binding. PMID:34383488
A fragment-based approach identifies an allosteric pocket that impacts malate dehydrogenase activity. PMID:34376783
Bdellovibrio bacteriovorus phosphoglucose isomerase structures reveal novel rigidity in the active site of a selected subset of enzymes upon substrate binding. PMID:34375548
Structural Basis and Mode of Action for Two Broadly Neutralizing Antibodies Against SARS-CoV-2 Emerging Variants of Concern. PMID:34373853
Structure of a meiosis-specific complex central to BRCA2 localization at recombination sites. PMID:34373645
Assessing the binding properties of CASP14 targets and models. PMID:34368994
The intervening domain is required for DNA-binding and functional identity of plant MADS transcription factors. PMID:34362909
Crystal Structure Reveals the Full Ras-Raf Interface and Advances Mechanistic Understanding of Raf Activation. PMID:34356620
Characterization of a triad of genes in cyanophage S-2L sufficient to replace adenine by 2-aminoadenine in bacterial DNA. PMID:34354070
Structural insight into host plasma membrane association and assembly of HIV-1 matrix protein. PMID:34349176
Using yeast two-hybrid system and molecular dynamics simulation to detect venom protein-protein interactions. PMID:34345854
Crystal structure of the MyRF ICA domain with its upstream β-helical stalk reveals the molecular mechanisms underlying its trimerization and self-cleavage. PMID:34345217
Structural studies of complexes of kallikrein 4 with wild-type and mutated forms of the Kunitz-type inhibitor BbKI. PMID:34342281
Structures of full-length VanR from Streptomyces coelicolor in both the inactive and activated states. PMID:34342276
The X-ray structure of L-threonine dehydrogenase from the common hospital pathogen Clostridium difficile. PMID:34341193
Conformational changes of loops highlight a potential binding site in Rhodococcus equi VapB. PMID:34341190
Crystal structure of the TLDc domain of human NCOA7-AS. PMID:34341188
SAMase of Bacteriophage T3 Inactivates Escherichia coli's Methionine S-Adenosyltransferase by Forming Heteropolymers. PMID:34340545
Structural insights into Cullin4-RING ubiquitin ligase remodelling by Vpr from simian immunodeficiency viruses. PMID:34339457
Affinity maturation of SARS-CoV-2 neutralizing antibodies confers potency, breadth, and resilience to viral escape mutations. PMID:34331873
A synthetic nanobody targeting RBD protects hamsters from SARS-CoV-2 infection. PMID:34330908
Probing the role of the residues in the active site of the transaminase from Thermobaculum terrenum. PMID:34324538
Mycobacterium tuberculosis Protein PE6 (Rv0335c), a Novel TLR4 Agonist, Evokes an Inflammatory Response and Modulates the Cell Death Pathways in Macrophages to Enhance Intracellular Survival. PMID:34322125
Solenoid architecture of HUWE1 contributes to ligase activity and substrate recognition. PMID:34314700
Mechanism of DNA Interaction and Translocation by the Replicase of a Circular Rep-Encoding Single-Stranded DNA Virus. PMID:34311576
Direct-MS analysis of antibody-antigen complexes. PMID:34310051
The 5-Ketofructose Reductase of Gluconobacter sp. Strain CHM43 Is a Novel Class in the Shikimate Dehydrogenase Family. PMID:34309403
Structural and Biochemical Characterization of the Flavin-Dependent Siderophore-Interacting Protein from Acinetobacter baumannii. PMID:34308084
Evolution of a σ-(c-di-GMP)-anti-σ switch. PMID:34290147
Co-evolutionary landscape at the interface and non-interface regions of protein-protein interaction complexes. PMID:34285778
Comparative analysis of two paradigm bacteriophytochromes reveals opposite functionalities in two-component signaling. PMID:34285211
Near-Pan-neutralizing, Plasma Deconvoluted Antibody N49P6 Mimics Host Receptor CD4 in Its Quaternary Interactions with the HIV-1 Envelope Trimer. PMID:34281393
The Plastid-Encoded RNA Polymerase-Associated Protein PAP9 Is a Superoxide Dismutase With Unusual Structural Features. PMID:34276730
The endopeptidase of the maize-affecting Marafivirus type member maize rayado fino virus doubles as a deubiquitinase. PMID:34265303
Talin rod domain-containing protein 1 (TLNRD1) is a novel actin-bundling protein which promotes filopodia formation. PMID:34264272
Helical reconstruction of Salmonella and Shigella needle filaments attached to type 3 basal bodies. PMID:34258394
Fixed-target serial femtosecond crystallography using in cellulo grown microcrystals. PMID:34258014
Putative hexameric glycosyltransferase functional unit revealed by the crystal structure of Acinetobacter baumannii MurG. PMID:34258006
Reduced neutralization of SARS-CoV-2 B.1.617 by vaccine and convalescent serum. PMID:34242578
Deep Learning for Protein-Protein Interaction Site Prediction. PMID:34236667
Structural and biochemical analyses of concanavalin A circular permutation by jack bean asparaginyl endopeptidase. PMID:34235541
Integrated analysis of Shank1 PDZ interactions with C-terminal and internal binding motifs. PMID:34235485
Structures of teixobactin-producing nonribosomal peptide synthetase condensation and adenylation domains. PMID:34235466
Predicted structural mimicry of spike receptor-binding motifs from highly pathogenic human coronaviruses. PMID:34234921
PDBrenum: A webserver and program providing Protein Data Bank files renumbered according to their UniProt sequences. PMID:34228733
Cryo-EM structure and dynamics of the green-light absorbing proteorhodopsin. PMID:34226545
Structural Basis for a Neutralizing Antibody Response Elicited by a Recombinant Hantaan Virus Gn Immunogen. PMID:34225492
Impact of Structural Observables From Simulations to Predict the Effect of Single-Point Mutations in MHC Class II Peptide Binders. PMID:34222328
Cryo-EM structure of the periplasmic tunnel of T7 DNA-ejectosome at 2.7 Å resolution. PMID:34214465
Transamidation Down-Regulates Intestinal Immunity of Recombinant α-Gliadin in HLA-DQ8 Transgenic Mice. PMID:34209932
The Molecular Basis for Escherichia coli O157:H7 Phage FAHEc1 Endolysin Function and Protein Engineering to Increase Thermal Stability. PMID:34207694
Structural Evidence of Active Site Adaptability towards Different Sized Substrates of Aromatic Amino Acid Aminotransferase from Psychrobacter Sp. B6. PMID:34204354
Structural and Biochemical Characterization of a Dye-Decolorizing Peroxidase from Dictyostelium discoideum. PMID:34200865
Structural and evolutionary exploration of the IL-3 family and its alpha subunit receptors. PMID:34196789
Entropic pressure controls the oligomerization of the Vibrio cholerae ParD2 antitoxin. PMID:34196617
Crystal structures of HER3 extracellular domain 4 in complex with the designed ankyrin-repeat protein D5. PMID:34196609
Functional and structural investigation of N-terminal domain of the SpTad2/3 heterodimeric tRNA deaminase. PMID:34194665
Structural Comparison Between MHC Classes I and II; in Evolution, a Class-II-Like Molecule Probably Came First. PMID:34194421
RAS-inhibiting biologics identify and probe druggable pockets including an SII-α3 allosteric site. PMID:34193876
Xyloglucan processing machinery in Xanthomonas pathogens and its role in the transcriptional activation of virulence factors. PMID:34193873
Nse5/6 inhibits the Smc5/6 ATPase and modulates DNA substrate binding. PMID:34191293
Understanding and Engineering the Stereoselectivity of Humulene Synthase. PMID:34180566
Unexpected Gating Behaviour of an Engineered Potassium Channel Kir. PMID:34179097
Learning from Nature: From a Marine Natural Product to Synthetic Cyclooxygenase-1 Inhibitors by Automated De Novo Design. PMID:34176236
A Crystallographic Snapshot of SARS-CoV-2 Main Protease Maturation Process. PMID:34174328
Structural insights into the functional divergence of WhiB-like proteins in Mycobacterium tuberculosis. PMID:34171298
A novel catalytic heme cofactor in SfmD with a single thioether bond and a bis-His ligand set revealed by a de novo crystal structural and spectroscopic study. PMID:34163669
Structure of the Arabidopsis thaliana glutamate receptor-like channel GLR3.4. PMID:34161757
Potent Human Single-Domain Antibodies Specific for a Novel Prefusion Epitope of Respiratory Syncytial Virus F Glycoprotein. PMID:34160257
Native mass spectrometry analyses of chaperonin complex TRiC/CCT reveal subunit N-terminal processing and re-association patterns. PMID:34158536
The MLKL kinase-like domain dimerization is an indispensable step of mammalian MLKL activation in necroptosis signaling. PMID:34158471
Epitope Classification and RBD Binding Properties of Neutralizing Antibodies Against SARS-CoV-2 Variants of Concern. PMID:34149735
The Structure of a Peptide-Loaded Shark MHC Class I Molecule Reveals Features of the Binding between β2-Microglobulin and H Chain Conserved in Evolution. PMID:34145057
Phylogenetic and Structural Analysis of NIN-Like Proteins With a Type I/II PB1 Domain That Regulates Oligomerization for Nitrate Response. PMID:34135927
Two human antibodies to a meningococcal serogroup B vaccine antigen enhance binding of complement Factor H by stabilizing the Factor H binding site. PMID:34125873
Quantitative description of a contractile macromolecular machine. PMID:34117062
Structural basis for accommodation of emerging B.1.351 and B.1.1.7 variants by two potent SARS-CoV-2 neutralizing antibodies. PMID:34111408
Structural Design and Analysis of the RHOA-ARHGEF1 Binding Mode: Challenges and Applications for Protein-Protein Interface Prediction. PMID:34109211
Computational Studies of the Structural Basis of Human RPS19 Mutations Associated With Diamond-Blackfan Anemia. PMID:34108988
The zinc-finger protein Red1 orchestrates MTREC submodules and binds the Mtl1 helicase arch domain. PMID:34103492
Computational Resources for Bioscience Education. PMID:34101113
Assessment of protein-protein interfaces in cryo-EM derived assemblies. PMID:34099703
Mutation-induced dimerization of transforming growth factor-β-induced protein may drive protein aggregation in granular corneal dystrophy. PMID:34097874
Redefining Protein Interfaces within Protein Single Crystals with DNA. PMID:34096291
Crystal Structure of the [4Fe-4S] Cluster-Containing Adenosine-5'-phosphosulfate Reductase from Mycobacterium tuberculosis. PMID:34095667
Decoding the intricate network of molecular interactions of a hyperstable engineered biocatalyst. PMID:34094357
Structures of the human cholecystokinin 1 (CCK1) receptor bound to Gs and Gq mimetic proteins provide insight into mechanisms of G protein selectivity. PMID:34086670
PDBe Aggregated API: Programmatic access to an integrative knowledge graph of molecular structure data. PMID:34081107
Reviving lost binding sites: Exploring calcium-binding site transitions between human and murine CD23. PMID:34075727
Copper binding by a unique family of metalloproteins is dependent on kynurenine formation. PMID:34074779
NAD(H)-mediated tetramerization controls the activity of Legionella pneumophila phospholipase PlaB. PMID:34074754
Structural insights into dpCoA-RNA decapping by NudC. PMID:34074215
Structure and Thermal Stability of wtRop and RM6 Proteins through All-Atom Molecular Dynamics Simulations and Experiments. PMID:34073028
Attacking COVID-19 Progression Using Multi-Drug Therapy for Synergetic Target Engagement. PMID:34071060
KEAP1 Cancer Mutants: A Large-Scale Molecular Dynamics Study of Protein Stability. PMID:34065616
Sphingomonas sp. KT-1 PahZ2 Structure Reveals a Role for Conformational Dynamics in Peptide Bond Hydrolysis. PMID:34060838
Polysaccharide utilization loci-driven enzyme discovery reveals BD-FAE: a bifunctional feruloyl and acetyl xylan esterase active on complex natural xylans. PMID:34059129
Destabilization of EpCAM dimer is associated with increased susceptibility towards cleavage by TACE. PMID:34055495
Order from disorder in the sarcomere: FATZ forms a fuzzy but tight complex and phase-separated condensates with α-actinin. PMID:34049882
Cryo-EM structure of type 1 IP3R channel in a lipid bilayer. PMID:34035440
Structures of the alkanesulfonate monooxygenase MsuD provide insight into C-S bond cleavage, substrate scope, and an unexpected role for the tetramer. PMID:34029591
The archaeal triphosphate tunnel metalloenzyme SaTTM defines structural determinants for the diverse activities in the CYTH protein family. PMID:34029589
Potent SARS-CoV-2 binding and neutralization through maturation of iconic SARS-CoV-1 antibodies. PMID:34024246
A comprehensive review of m6A/m6Am RNA methyltransferase structures. PMID:34023900
Structural and conformational analysis of SARS CoV 2 N-CTD revealing monomeric and dimeric active sites during the RNA-binding and stabilization: Insights towards potential inhibitors for N-CTD. PMID:34022485
Bacterial Evolutionary Precursors of Eukaryotic Copper-Zinc Superoxide Dismutases. PMID:34021750
Cryo-EM structure of mammalian RNA polymerase II in complex with human RPAP2. PMID:34021257
Molecular mechanism of N-terminal acetylation by the ternary NatC complex. PMID:34019809
Dipeptidyl peptidase 9 sets a threshold for CARD8 inflammasome formation by sequestering its active C-terminal fragment. PMID:34019797
Structural and functional ramifications of antigenic drift in recent SARS-CoV-2 variants. PMID:34016740
ProtCHOIR: a tool for proteome-scale generation of homo-oligomers. PMID:34015821
B cell genomics behind cross-neutralization of SARS-CoV-2 variants and SARS-CoV. PMID:34015271
Significantly improving the thermostability of a hyperthermophilic GH10 family xylanase XynAF1 by semi-rational design. PMID:34014347
Structural Profiling of Bacterial Effectors Reveals Enrichment of Host-Interacting Domains and Motifs. PMID:34012977
RGS5-TGFβ-Smad2/3 axis switches pro- to anti-apoptotic signaling in tumor-residing pericytes, assisting tumor growth. PMID:34012071
Phospholipid translocation captured in a bifunctional membrane protein MprF. PMID:34006869
Functional and structural characterization of a two-MAb cocktail for delayed treatment of enterovirus D68 infections. PMID:34006855
Noncanonical protein kinase A activation by oligomerization of regulatory subunits as revealed by inherited Carney complex mutations. PMID:34006641
Characterization of a novel type of carbonic anhydrase that acts without metal cofactors. PMID:34006275
Structural model of the M7G46 Methyltransferase TrmB in complex with tRNA. PMID:34006170
Computational designing of a peptide that potentially blocks the entry of SARS-CoV, SARS-CoV-2 and MERS-CoV. PMID:34003827
A Structural Landscape of Neutralizing Antibodies Against SARS-CoV-2 Receptor Binding Domain. PMID:33995366
The structure of an infectious immature flavivirus redefines viral architecture and maturation. PMID:33990320
Crystal structure and mutational analysis of the human TRIM7 B30.2 domain provide insights into the molecular basis of its binding to glycogenin-1. PMID:33989636
Crystal and solution structures reveal oligomerization of individual capsid homology domains of Drosophila Arc. PMID:33989344
Surface-Induced Dissociation of Anionic vs Cationic Native-Like Protein Complexes. PMID:33983719
Structure and dynamics of a mycobacterial type VII secretion system. PMID:33981042
Structure prediction and function characterization of WC-2 proteins in Blakeslea trispora. PMID:33973112
MyD88 TIR domain higher-order assembly interactions revealed by microcrystal electron diffraction and serial femtosecond crystallography. PMID:33972532
Structural and mechanistic insights into the bifunctional HISN2 enzyme catalyzing the second and third steps of histidine biosynthesis in plants. PMID:33958623
Structural insights into the cross-neutralization of SARS-CoV and SARS-CoV-2 by the human monoclonal antibody 47D11. PMID:33958322
A fragment-based protein interface design algorithm for symmetric assemblies. PMID:33955480
Structural and functional analysis of the Klebsiella pneumoniae MazEF toxin-antitoxin system. PMID:33953923
Computational Methods for the Elucidation of Protein Structure and Interactions. PMID:33950383
Metabolic bifunctionality of Rv0812 couples folate and peptidoglycan biosynthesis in Mycobacterium tuberculosis. PMID:33950161
Structural basis of chitin utilization by a GH20 β-N-acetylglucosaminidase from Vibrio campbellii strain ATCC BAA-1116. PMID:33950022
Crystal structure of enoyl-CoA hydratase from Thermus thermophilus HB8. PMID:33949975
Structure and Mechanism of d-Glucosaminate-6-phosphate Ammonia-lyase: A Novel Octameric Assembly for a Pyridoxal 5'-Phosphate-Dependent Enzyme, and Unprecedented Stereochemical Inversion in the Elimination Reaction of a d-Amino Acid. PMID:33949189
Broad cross-reactivity across sarbecoviruses exhibited by a subset of COVID-19 donor-derived neutralizing antibodies. PMID:33948592
Structures of a non-ribosomal peptide synthetase condensation domain suggest the basis of substrate selectivity. PMID:33947858
Crystal Structure of Escherichia coli Agmatinase: Catalytic Mechanism and Residues Relevant for Substrate Specificity. PMID:33946272
Diverse immunoglobulin gene usage and convergent epitope targeting in neutralizing antibody responses to SARS-CoV-2. PMID:33932326
The 'Shape-Shifter' Peptide from the Disulphide Isomerase PmScsC Shows Context-Dependent Conformational Preferences. PMID:33926076
Solution and Membrane Interaction Dynamics of Mycobacterium tuberculosis Fatty Acyl-CoA Synthetase FadD13. PMID:33913324
ZapG (YhcB/DUF1043), a novel cell division protein in gamma-proteobacteria linking the Z-ring to septal peptidoglycan synthesis. PMID:33895137
A combination of cross-neutralizing antibodies synergizes to prevent SARS-CoV-2 and SARS-CoV pseudovirus infection. PMID:33894127
The structure of POMGNT2 provides new insights into the mechanism to determine the functional O-mannosylation site on α-dystroglycan. PMID:33893702
Specificity of AMPylation of the human chaperone BiP is mediated by TPR motifs of FICD. PMID:33893288
Multiple substrate recognition by yeast diadenosine and diphosphoinositol polyphosphate phosphohydrolase through phosphate clamping. PMID:33893105
Molecular basis for Ras suppressor-1 binding to PINCH-1 in focal adhesion assembly. PMID:33891945
Crystal structure and molecular dynamics of human POLDIP2, a multifaceted adaptor protein in metabolism and genome stability. PMID:33884680
Dimer Asymmetry and Light Activation Mechanism in Brucella Blue-Light Sensor Histidine Kinase. PMID:33879593
The SARS-unique domain (SUD) of SARS-CoV and SARS-CoV-2 interacts with human Paip1 to enhance viral RNA translation. PMID:33876849
Human DND1-RRM2 forms a non-canonical domain swapped dimer. PMID:33860980
Structure of the E. coli agmatinase, SPEB. PMID:33857156
Antibody evasion by the P.1 strain of SARS-CoV-2. PMID:33852911
The tissue protective functions of interleukin-22 can be decoupled from pro-inflammatory actions through structure-based design. PMID:33852830
Conformational interconversion of MLKL and disengagement from RIPK3 precede cell death by necroptosis. PMID:33850121
The Botrytis cinerea Crh1 transglycosylase is a cytoplasmic effector triggering plant cell death and defense response. PMID:33846308
Crystal structure of a novel homodimeric l-ribulose 3-epimerase from Methylomonus sp. PMID:33838083
Broad and potent neutralizing human antibodies to tick-borne flaviviruses protect mice from disease. PMID:33831141
A Norovirus Uses Bile Salts To Escape Antibody Recognition While Enhancing Receptor Binding. PMID:33827952
A human antibody reveals a conserved site on beta-coronavirus spike proteins and confers protection against SARS-CoV-2 infection. PMID:33821273
Ultrapotent bispecific antibodies neutralize emerging SARS-CoV-2 variants. PMID:33821267
Structural and Biochemical Analysis of OrfG: The VirB8-like Component of the Conjugative Type IV Secretion System of ICESt3 From Streptococcus thermophilus. PMID:33816557
The Crystal Structure of Bacillus cereus HblL1. PMID:33807365
Broad Reactivity Single Domain Antibodies against Influenza Virus and Their Applications to Vaccine Potency Testing and Immunotherapy. PMID:33802072
In Silico Investigation of Potential Applications of Gamma Carbonic Anhydrases as Catalysts of CO2 Biomineralization Processes: A Visit to the Thermophilic Bacteria Persephonella hydrogeniphila, Persephonella marina, Thermosulfidibacter takaii, and Thermus thermophilus. PMID:33799806
Membrane Barrels Are Taller, Fatter, Inside-Out Soluble Barrels. PMID:33797916
Crystal structure of human interleukin-2 in complex with TCB2, a new antibody-drug candidate with antitumor activity. PMID:33796411
Structural basis of FANCD2 deubiquitination by USP1-UAF1. PMID:33795880
Effective rational humanization of a PASylated anti-galectin-3 Fab for the sensitive PET imaging of thyroid cancer in vivo. PMID:33795750
Structure of the complete, membrane-assembled COPII coat reveals a complex interaction network. PMID:33795673
Modular basis for potent SARS-CoV-2 neutralization by a prevalent VH1-2-derived antibody class. PMID:33794145
Protein Footprinting, Conformational Dynamics, and Core Interface-Adjacent Neutralization "Hotspots" in the SARS-CoV-2 Spike Protein Receptor Binding Domain/Human ACE2 Interaction. PMID:33794092
Potent SARS-CoV-2 neutralizing antibodies directed against spike N-terminal domain target a single supersite. PMID:33789084
Crystal structures of influenza nucleoprotein complexed with nucleic acid provide insights into the mechanism of RNA interaction. PMID:33784403
MCPdb: The bacterial microcompartment database. PMID:33780471
PIM-induced phosphorylation of Notch3 promotes breast cancer tumorigenicity in a CSL-independent fashion. PMID:33775697
Structural and Drug Screening Analysis of the Non-structural Proteins of Severe Acute Respiratory Syndrome Coronavirus 2 Virus Extracted From Indian Coronavirus Disease 2019 Patients. PMID:33767730
The actomyosin interface contains an evolutionary conserved core and an ancillary interface involved in specificity. PMID:33767187
Development of potency, breadth and resilience to viral escape mutations in SARS-CoV-2 neutralizing antibodies. PMID:33758864
Canonical versus non-canonical transsynaptic signaling of neuroligin 3 tunes development of sociality in mice. PMID:33758193
Evolved increases in hemoglobin-oxygen affinity and the Bohr effect coincided with the aquatic specialization of penguins. PMID:33753505
Oligomeric quaternary structure of Escherichia coli and Mycobacterium smegmatis Lhr helicases is nucleated by a novel C-terminal domain composed of five winged-helix modules. PMID:33744958
Reduced neutralization of SARS-CoV-2 B.1.1.7 variant by convalescent and vaccine sera. PMID:33743891
Structural basis of the dynamic human CEACAM1 monomer-dimer equilibrium. PMID:33742094
A human monoclonal antibody blocks malaria transmission and defines a highly conserved neutralizing epitope on gametes. PMID:33741942
Simultaneous binding of Guidance Cues NET1 and RGM blocks extracellular NEO1 signaling. PMID:33740419
DPP9 sequesters the C terminus of NLRP1 to repress inflammasome activation. PMID:33731932
Structure of Arabidopsis CESA3 catalytic domain with its substrate UDP-glucose provides insight into the mechanism of cellulose synthesis. PMID:33729990
Crystal structure of P. falciparum Cpn60 bound to ATP reveals an open dynamic conformation before substrate binding. PMID:33723304
Crystal structure of timothy grass allergen Phl p 12.0101 reveals an unusual profilin dimer. PMID:33720678
Peptidoglycan binding by a pocket on the accessory NTF2-domain of Pgp2 directs helical cell shape of Campylobacter jejuni. PMID:33711341
DNA-Directed Protein Packing within Single Crystals. PMID:33709040
Crystallographic models of SARS-CoV-2 3CLpro: in-depth assessment of structure quality and validation. PMID:33708401
Crystal structure of the nonclassical cadherin-17 N-terminus and implications for its adhesive binding mechanism. PMID:33682793
Mechanistic insights into the effect of phosphorylation on Ras conformational dynamics and its interactions with cell signaling proteins. PMID:33680360
Small-Angle X-ray Scattering Models of APOBEC3B Catalytic Domain in a Complex with a Single-Stranded DNA Inhibitor. PMID:33673243
Multivalent Display of SARS-CoV-2 Spike (RBD Domain) of COVID-19 to Nanomaterial, Protein Ferritin Nanocages. PMID:33671255
Interactions of Sea Anemone Toxins with Insect Sodium Channel-Insights from Electrophysiology and Molecular Docking Studies. PMID:33670972
A polysaccharide utilization locus from the gut bacterium Dysgonomonas mossii encodes functionally distinct carbohydrate esterases. PMID:33667545
Structure of 3-mercaptopropionic acid dioxygenase with a substrate analog reveals bidentate substrate binding at the iron center. PMID:33662397
Virion structure and in vitro genome release mechanism of dicistrovirus Kashmir bee virus. PMID:33658338
SARM1 is a metabolic sensor activated by an increased NMN/NAD+ ratio to trigger axon degeneration. PMID:33657413
Large-scale discovery of protein interactions at residue resolution using co-evolution calculated from genomic sequences. PMID:33654096
Structural characterization of the microbial enzyme urocanate reductase mediating imidazole propionate production. PMID:33649331
Targeting a neoantigen derived from a common TP53 mutation. PMID:33649166
Second distinct conformation of the phosphohistidine loop in succinyl-CoA synthetase. PMID:33645539
Crystal structures of adenylylated and unadenylylated PII protein GlnK from Corynebacterium glutamicum. PMID:33645536
Structural basis of diversity and homodimerization specificity of zinc-finger-associated domains in Drosophila. PMID:33638995
Co-crystallization with diabodies: A case study for the introduction of synthetic symmetry. PMID:33636101
Structural analysis and biochemical properties of laccase enzymes from two Pediococcus species. PMID:33635570
Prokaryotic Argonaute from Archaeoglobus fulgidus interacts with DNA as a homodimer. PMID:33633170
Crystal structure of acetoacetyl-CoA reductase from Rickettsia felis. PMID:33620038
Shedding Light on the Inhibitory Mechanisms of SARS-CoV-1/CoV-2 Spike Proteins by ACE2-Designed Peptides. PMID:33619962
Three-dimensional structure of human cyclooxygenase (hCOX)-1. PMID:33619313
Expanding the recognition interface of the thrombin-binding aptamer HD1 through modification of residues T3 and T12. PMID:33614235
Structural characterization of a PCP-R didomain from an archaeal nonribosomal peptide synthetase reveals novel interdomain interactions. PMID:33610550
Structural basis for IL-12 and IL-23 receptor sharing reveals a gateway for shaping actions on T versus NK cells. PMID:33606986
Nonstructural protein 7 and 8 complexes of SARS-CoV-2. PMID:33594727
A combination of cross-neutralizing antibodies synergizes to prevent SARS-CoV-2 and SARS-CoV pseudovirus infection. PMID:33594361
Structural Characterization of Diazabicyclooctane β-Lactam "Enhancers" in Complex with Penicillin-Binding Proteins PBP2 and PBP3 of Pseudomonas aeruginosa. PMID:33593978
Insights into Ubiquitin Product Release in Hydrolysis Catalyzed by the Bacterial Deubiquitinase SdeA. PMID:33583181
C. elegans germ granules require both assembly and localized regulators for mRNA repression. PMID:33579952
Granulovirus PK-1 kinase activity relies on a side-to-side dimerization mode centered on the regulatory αC helix. PMID:33579933
The allosteric modulation of complement C5 by knob domain peptides. PMID:33570492
Functional and structural characterization of a flavoprotein monooxygenase essential for biogenesis of tryptophylquinone cofactor. PMID:33568660
Exploiting Allosteric Properties of RAF and MEK Inhibitors to Target Therapy-Resistant Tumors Driven by Oncogenic BRAF Signaling. PMID:33568355
C-phycocyanin as a highly attractive model system in protein crystallography: unique crystallization properties and packing-diversity screening. PMID:33559611
Unveiling the binding mode of perfluorooctanoic acid to human serum albumin. PMID:33550662
Multiple variants of the fungal effector AVR-Pik bind the HMA domain of the rice protein OsHIPP19, providing a foundation to engineer plant defense. PMID:33548226
Crystal structure of the human PRPK-TPRKB complex. PMID:33547416
Structural and Biochemical Characterization of EFhd1/Swiprosin-2, an Actin-Binding Protein in Mitochondria. PMID:33537316
A scaffold lncRNA shapes the mitosis to meiosis switch. PMID:33536434
Interplay between hevin, SPARC, and MDGAs: Modulators of neurexin-neuroligin transsynaptic bridges. PMID:33535026
Structure-function studies of the C3/C5 epimerases and C4 reductases of the Campylobacter jejuni capsular heptose modification pathways. PMID:33524389
Oncogenic mutations on Rac1 affect global intrinsic dynamics underlying GTP and PAK1 binding. PMID:33515600
SARS-CoV-2 and other human coronaviruses: Mapping of protease recognition sites, antigenic variation of spike protein and their grouping through molecular phylogenetics. PMID:33497837
Unique structural solution from a VH3-30 antibody targeting the hemagglutinin stem of influenza A viruses. PMID:33495478
Structural characterization of Myxococcus xanthus MglC, a component of the polarity control system, and its interactions with its paralog MglB. PMID:33493516
How Far Are We from the Rapid Prediction of Drug Resistance Arising Due to Kinase Mutations? PMID:33490784
A two-site flexible clamp mechanism for RET-GDNF-GFRα1 assembly reveals both conformational adaptation and strict geometric spacing. PMID:33484636
Structural basis for transcription complex disruption by the Mfd translocase. PMID:33480355
Dynamic association of human Ebp1 with the ribosome. PMID:33479117
Structural basis of trehalose recognition by the mycobacterial LpqY-SugABC transporter. PMID:33476646
The complex structure of GRL0617 and SARS-CoV-2 PLpro reveals a hot spot for antiviral drug discovery. PMID:33473130
Facile Fabrication of Protein-Macrocycle Frameworks. PMID:33470808
Molecular basis of IRGB10 oligomerization and membrane association for pathogen membrane disruption. PMID:33469160
Classification and prediction of protein-protein interaction interface using machine learning algorithm. PMID:33469042
Rab1-AMPylation by Legionella DrrA is allosterically activated by Rab1. PMID:33469029
Structural and Biochemical Characterization of a Cold-Active PMGL3 Esterase with Unusual Oligomeric Structure. PMID:33466452
Structural analysis of cross α-helical nanotubes provides insight into the designability of filamentous peptide nanomaterials. PMID:33462223
Antibiotic binding releases autoinhibition of the TipA multidrug-resistance transcriptional regulator. PMID:33454020
Structural basis for allosteric regulation of pyruvate kinase M2 by phosphorylation and acetylation. PMID:33453989
Inositol pyrophosphates promote the interaction of SPX domains with the coiled-coil motif of PHR transcription factors to regulate plant phosphate homeostasis. PMID:33452263
Wzb of Vibrio vulnificus represents a new group of low-molecular-weight protein tyrosine phosphatases with a unique insertion in the W-loop. PMID:33450227
Crystal structures of the EVE-HNH endonuclease VcaM4I in the presence and absence of DNA. PMID:33450012
Structural characterization of a GNAT family acetyltransferase from Elizabethkingia anophelis bound to acetyl-CoA reveals a new dimeric interface. PMID:33446675
Crystal structure and DNA cleavage mechanism of the restriction DNA glycosylase R.CcoLI from Campylobacter coli. PMID:33441677
A therapeutic neutralizing antibody targeting receptor binding domain of SARS-CoV-2 spike protein. PMID:33436577
Structure-guided multivalent nanobodies block SARS-CoV-2 infection and suppress mutational escape. PMID:33436526
Structural basis for multifunctional roles of human Ints3 C-terminal domain. PMID:33434574
Structure and mechanism of the proton-driven motor that powers type 9 secretion and gliding motility. PMID:33432152
Surface hydrophobics mediate functional dimerization of CYP121A1 of Mycobacterium tuberculosis. PMID:33431984
Cryo-EM structure of Helicobacter pylori urease with an inhibitor in the active site at 2.0 Å resolution. PMID:33431861
Homotypic CARD-CARD interaction is critical for the activation of NLRP1 inflammasome. PMID:33431827
Advances in integrative structural biology: Towards understanding protein complexes in their cellular context. PMID:33425253
A Novel Design of Multi-epitope Vaccine Against Helicobacter pylori by Immunoinformatics Approach. PMID:33424523
Development of a structural epitope mimic: an idiotypic approach to HCV vaccine design. PMID:33420102
Inhibition of the Complement Alternative Pathway by Chemically Modified DNA Aptamers That Bind with Picomolar Affinity to Factor B. PMID:33419768
Structural Characterization of Act c 10.0101 and Pun g 1.0101-Allergens from the Non-Specific Lipid Transfer Protein Family. PMID:33419110
SARS-CoV-2 3D database: understanding the coronavirus proteome and evaluating possible drug targets. PMID:33416848
Molecular basis for the adaptive evolution of environment-sensing by H-NS proteins. PMID:33410747
Crystal structure of bacterial cytotoxic necrotizing factor CNFY reveals molecular building blocks for intoxication. PMID:33410511
The Majority of Typhoid Toxin-Positive Salmonella Serovars Encode ArtB, an Alternate Binding Subunit. PMID:33408236
Structural basis of Naa20 activity towards a canonical NatB substrate. PMID:33398031
Structural insights into photoactivation of plant Cryptochrome-2. PMID:33398020
ADP-ribose and analogues bound to the deMARylating macrodomain from the bat coronavirus HKU4. PMID:33397718
Rational selection of building blocks for the assembly of bispecific antibodies. PMID:33397191
Dissecting the Mechanism of (R)-3-Hydroxybutyrate Dehydrogenase by Kinetic Isotope Effects, Protein Crystallography, and Computational Chemistry. PMID:33391858
An Eight Amino Acid Segment Controls Oligomerization and Preferred Conformation of the two Non-visual Arrestins. PMID:33387531
A novel circulating tamiami mammarenavirus shows potential for zoonotic spillover. PMID:33370288
Structure of SARS-CoV-2 ORF8, a rapidly evolving immune evasion protein. PMID:33361333
Opposite Surfaces of the Cdc15 F-BAR Domain Create a Membrane Platform That Coordinates Cytoskeletal and Signaling Components for Cytokinesis. PMID:33357436
Fermented Soy-Derived Bioactive Peptides Selected by a Molecular Docking Approach Show Antioxidant Properties Involving the Keap1/Nrf2 Pathway. PMID:33352784
Molecular rationale for antibody-mediated targeting of the hantavirus fusion glycoprotein. PMID:33349334
Mycobacterial HelD is a nucleic acids-clearing factor for RNA polymerase. PMID:33339823
Molecular basis for RNA polymerase-dependent transcription complex recycling by the helicase-like motor protein HelD. PMID:33339820
Structural Characterization of Glycerol Kinase from the Thermophilic Fungus Chaetomium thermophilum. PMID:33339113
A structurally unique Fusobacterium nucleatum tannase provides detoxicant activity against gallotannins and pathogen resistance. PMID:33336898
Structure of transmembrane prolyl 4-hydroxylase reveals unique organization of EF and dioxygenase domains. PMID:33334883
Capping pores of alphavirus nsP1 gate membranous viral replication factories. PMID:33328629
The structure of SeviL, a GM1b/asialo-GM1 binding R-type lectin from the mussel Mytilisepta virgata. PMID:33328520
Suppressor Mutations in Type II Secretion Mutants of Vibrio cholerae: Inactivation of the VesC Protease. PMID:33328352
Structural Insight into the Contributions of the N-Terminus and Key Active-Site Residues to the Catalytic Efficiency of Glutamine Synthetase 2. PMID:33327463
GAG-DB, the New Interface of the Three-Dimensional Landscape of Glycosaminoglycans. PMID:33322545
Structure of a GRK5-Calmodulin Complex Reveals Molecular Mechanism of GRK Activation and Substrate Targeting. PMID:33321095
Structural characterization of nonstructural protein 1 from SARS-CoV-2. PMID:33319167
Structure of the radial spoke head and insights into its role in mechanoregulation of ciliary beating. PMID:33318704
Structural insights and evaluation of the potential impact of missense variants on the interactions of SLIT2 with ROBO1/4 in cancer progression. PMID:33318575
An improved fluorescent tag and its nanobodies for membrane protein expression, stability assay, and purification. PMID:33303987
Structural basis for antigen recognition by methylated lysine-specific antibodies. PMID:33303630
Structures of three MORN repeat proteins and a re-evaluation of the proposed lipid-binding properties of MORN repeats. PMID:33296386
Phylogenetics-based identification and characterization of a superior 2,3-butanediol dehydrogenase for Zymomonas mobilis expression. PMID:33292448
Structural basis for the substrate specificity and catalytic features of pseudouridine kinase from Arabidopsis thaliana. PMID:33290549
Structure and Characterization of Phosphoglucomutase 5 from Atlantic and Baltic Herring-An Inactive Enzyme with Intact Substrate Binding. PMID:33287293
Conformational dynamics of SARS-CoV-2 trimeric spike glycoprotein in complex with receptor ACE2 revealed by cryo-EM. PMID:33277323
Cryo-EM structure of CtBP2 confirms tetrameric architecture. PMID:33264605
Identification of the Clostridial cellulose synthase and characterization of the cognate glycosyl hydrolase, CcsZ. PMID:33264329
The hypothetical periplasmic protein PA1624 from Pseudomonas aeruginosa folds into a unique two-domain structure. PMID:33263573
Structural ordering of the Plasmodium berghei circumsporozoite protein repeats by inhibitory antibody 3D11. PMID:33253113
From examining the relationship between (corona)viral adhesins and galectins to glyco-perspectives. PMID:33248129
Cross-Neutralization of a SARS-CoV-2 Antibody to a Functionally Conserved Site Is Mediated by Avidity. PMID:33242394
Structure and dsRNA-binding activity of the Birnavirus Drosophila X Virus VP3 protein. PMID:33239452
A complete rule set for designing symmetry combination materials from protein molecules. PMID:33239442
Structural Basis for High-Affinity Trapping of the NaV1.7 Channel in Its Resting State by Tarantula Toxin. PMID:33232657
Comparison of human poly-N-acetyl-lactosamine synthase structure with GT-A fold glycosyltransferases supports a modular assembly of catalytic subsites. PMID:33229435
Structure of an affinity-matured inhibitory recombinant fab against urokinase plasminogen activator reveals basis of potency and specificity. PMID:33221341
The flexible N-terminus of BchL autoinhibits activity through interaction with its [4Fe-4S] cluster and released upon ATP binding. PMID:33219127
Structural Basis of CYRI-B Direct Competition with Scar/WAVE Complex for Rac1. PMID:33217330
Molecular docking analysis of P2X7 receptor with the beta toxin from Clostridium perfringens. PMID:33214747
Lipocalin Blc is a potential heme-binding protein. PMID:33210733
Fatal outcome after heart surgery in PMM2-CDG due to a rare homozygous gene variant with double effects. PMID:33209585
The RNA Polymerase α Subunit Recognizes the DNA Shape of the Upstream Promoter Element. PMID:33205945
Succinic Semialdehyde Dehydrogenase Deficiency: In Vitro and In Silico Characterization of a Novel Pathogenic Missense Variant and Analysis of the Mutational Spectrum of ALDH5A1. PMID:33203024
Crystal Structure of Isoform CBd of the Basic Phospholipase A2 Subunit of Crotoxin: Description of the Structural Framework of CB for Interaction with Protein Targets. PMID:33202772
SAXS studies of X-ray induced disulfide bond damage: Engineering high-resolution insight from a low-resolution technique. PMID:33201877
NAP1-Related Protein 1 (NRP1) has multiple interaction modes for chaperoning histones H2A-H2B. PMID:33199628
The antibiotic sorangicin A inhibits promoter DNA unwinding in a Mycobacterium tuberculosis rifampicin-resistant RNA polymerase. PMID:33199626
Cryo-EM structure of native human uromodulin, a zona pellucida module polymer. PMID:33196145
Structure-Guided Molecular Engineering of a Vascular Endothelial Growth Factor Antagonist to Treat Retinal Diseases. PMID:33184574
Functional Cross-Talk of MbtH-Like Proteins During Thaxtomin Biosynthesis in the Potato Common Scab Pathogen Streptomyces scabiei. PMID:33178168
Multitask ATPases (NBDs) of bacterial ABC importers type I and their interspecies exchangeability. PMID:33177617
The cryo-EM structure of a γ-TuSC elucidates architecture and regulation of minimal microtubule nucleation systems. PMID:33177498
Bringing the Heavy Chain to Light: Creating a Symmetric, Bivalent IgG-Like Bispecific. PMID:33172091
Does it take two to tango? RING domain self-association and activity in TRIM E3 ubiquitin ligases. PMID:33170204
Mechanism of auto-inhibition and activation of Mec1ATR checkpoint kinase. PMID:33169019
The New Dipeptide TSPO Ligands: Design, Synthesis and Structure-Anxiolytic Activity Relationship. PMID:33158242
Large domain movements through the lipid bilayer mediate substrate release and inhibition of glutamate transporters. PMID:33155546
Peptide Inhibitors of the α-Cobratoxin-Nicotinic Acetylcholine Receptor Interaction. PMID:33143415
Structural Insight on Functional Regulation of Human MINERVA Protein. PMID:33142954
Biochemical and transcript level differences between the three human phosphofructokinases show optimisation of each isoform for specific metabolic niches. PMID:33141153
Divergent architecture of the heterotrimeric NatC complex explains N-terminal acetylation of cognate substrates. PMID:33139728
Alpha-Carbonic Anhydrases from Hydrothermal Vent Sources as Potential Carbon Dioxide Sequestration Agents: In Silico Sequence, Structure and Dynamics Analyses. PMID:33138066
Convergent structural features of respiratory syncytial virus neutralizing antibodies and plasticity of the site V epitope on prefusion F. PMID:33137810
Interaction of small molecules with the SARS-CoV-2 main protease in silico and in vitro validation of potential lead compounds using an enzyme-linked immunosorbent assay. PMID:33137690
Aequorea's secrets revealed: New fluorescent proteins with unique properties for bioimaging and biosensing. PMID:33137097
X-ray structure analysis of a unique D-amino-acid oxidase from the thermophilic fungus Rasamsonia emersonii strain YA. PMID:33135670
Alternative conformation of the C-domain of the P140 protein from Mycoplasma genitalium. PMID:33135669
Insight into human Miro1/2 domain organization based on the structure of its N-terminal GTPase. PMID:33132189
The ASK1 gene regulates the sensitivity of Fusarium graminearum to carbendazim, conidiation and sexual production by combining with β2-tubulin. PMID:33130939
The structure of a family 110 glycoside hydrolase provides insight into the hydrolysis of α-1,3-galactosidic linkages in λ-carrageenan and blood group antigens. PMID:33127644
Molecular characterization of the RNA-protein complex directing -2/-1 programmed ribosomal frameshifting during arterivirus replicase expression. PMID:33127640
Differences in structure and hibernation mechanism highlight diversification of the microsporidian ribosome. PMID:33125369
Leishmania differentiation requires ubiquitin conjugation mediated by a UBC2-UEV1 E2 complex. PMID:33108402
The structures of secretory and dimeric immunoglobulin A. PMID:33107820
Structure of Epstein-Barr virus tegument protein complex BBRF2-BSRF1 reveals its potential role in viral envelopment. PMID:33106493
The autoinhibited state of MKK4: Phosphorylation, putative dimerization and R134W mutant studied by molecular dynamics simulations. PMID:33101607
Insights into bacterial cell division from a structure of EnvC bound to the FtsX periplasmic domain. PMID:33097670
Hexachlorobenzene Monooxygenase Substrate Selectivity and Catalysis: Structural and Biochemical Insights. PMID:33097503
Structural analysis of CACHE domain of the McpA chemoreceptor from Leptospira interrogans. PMID:33097187
High-Resolution Crystal Structure of Chloroplastic Ribose-5-Phosphate Isomerase from Chlamydomonas reinhardtii-An Enzyme Involved in the Photosynthetic Calvin-Benson Cycle. PMID:33096784
Structural Basis for Toxin Inhibition in the VapXD Toxin-Antitoxin System. PMID:33096014
Type III ATP synthase is a symmetry-deviated dimer that induces membrane curvature through tetramerization. PMID:33093501
Understanding the Pathogenesis of Spondyloarthritis. PMID:33092023
Time-lapse sentinel surveillance of SARS-CoV-2 spread in India. PMID:33091066
Crystal structure of caspase-11 CARD provides insights into caspase-11 activation. PMID:33083005
Dimerization regulates the human APC/C-associated ubiquitin-conjugating enzyme UBE2S. PMID:33082289
Structural basis of heterotetrameric assembly and disease mutations in the human cis-prenyltransferase complex. PMID:33077723
Recognition of the SARS-CoV-2 receptor binding domain by neutralizing antibodies. PMID:33069360
Structural and functional analysis of protective antibodies targeting the threefold plateau of enterovirus 71. PMID:33067459
Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms. PMID:33060197
A Therapeutic Non-self-reactive SARS-CoV-2 Antibody Protects from Lung Pathology in a COVID-19 Hamster Model. PMID:33058755
Chlamydia trachomatis glyceraldehyde 3-phosphate dehydrogenase: Enzyme kinetics, high-resolution crystal structure, and plasminogen binding. PMID:33058314
Immunodominant proteins P1 and P40/P90 from human pathogen Mycoplasma pneumoniae. PMID:33057023
Structural basis for CDK7 activation by MAT1 and Cyclin H. PMID:33055219
Crystal Structure of Mannose Specific IIA Subunit of Phosphotransferase System from Streptococcus pneumoniae. PMID:33053673
Comparative docking studies to understand the binding affinity of nicotine with soluble ACE2 (sACE2)-SARS-CoV-2 complex over sACE2. PMID:33052306
Pseudo-repeats in doublecortin make distinct mechanistic contributions to microtubule regulation. PMID:33051979
Structural role of essential light chains in the apicomplexan glideosome. PMID:33051581
"The structure of the Type III secretion system export gate with CdsO, an ATPase lever arm". PMID:33048983
SARS-CoV-2 neutralizing antibody structures inform therapeutic strategies. PMID:33045718
Structural features and development of an assay platform of the parasite target deoxyhypusine synthase of Brugia malayi and Leishmania major. PMID:33044977
Comparison of tyrosine kinase domain properties for the neurotrophin receptors TrkA and TrkB. PMID:33043964
High-resolution cryo-EM structure of urease from the pathogen Yersinia enterocolitica. PMID:33037208
Structural characterization of the ICOS/ICOS-L immune complex reveals high molecular mimicry by therapeutic antibodies. PMID:33033255
Post-translational Regulation of DNA Polymerase η, a Connection to Damage-Induced Cohesion in Saccharomyces cerevisiae. PMID:33033113
Cryo-EM and MD infer water-mediated proton transport and autoinhibition mechanisms of Vo complex. PMID:33028525
Modulation of Guanylate Cyclase Activating Protein 1 (GCAP1) Dimeric Assembly by Ca2+ or Mg2+: Hints to Understand Protein Activity. PMID:33027977
An Alternative Binding Mode of IGHV3-53 Antibodies to the SARS-CoV-2 Receptor Binding Domain. PMID:33027617
The crystal structure of mycobacterial epoxide hydrolase A. PMID:33024154
Trypanosomatid selenophosphate synthetase structure, function and interaction with selenocysteine lyase. PMID:33017394
Domain-Swap Dimerization of Acanthamoeba castellanii CYP51 and a Unique Mechanism of Inactivation by Isavuconazole. PMID:33008918
4CMenB vaccine induces elite cross-protective human antibodies that compete with human factor H for binding to meningococcal fHbp. PMID:33007046
Structure of the substrate-binding domain of Plasmodium falciparum heat-shock protein 70-x. PMID:33006578
Crystal structure of XCC3289 from Xanthomonas campestris: homology with the N-terminal substrate-binding domain of Lon peptidase. PMID:33006577
Structures of ISCth4 transpososomes reveal the role of asymmetry in copy-out/paste-in DNA transposition. PMID:33006208
Characterizing human α-1,6-fucosyltransferase (FUT8) substrate specificity and structural similarities with related fucosyltransferases. PMID:33004438
Mutation of an atypical oxirane oxyanion hole improves regioselectivity of the α/β-fold epoxide hydrolase Alp1U. PMID:33004437
Global distribution of single amino acid polymorphisms in Plasmodium vivax Duffy-binding-like domain and implications for vaccine development efforts. PMID:32993415
Functional Recovery of a GCDH Variant Associated to Severe Deflavinylation-Molecular Insights into Potential Beneficial Effects of Riboflavin Supplementation in Glutaric Aciduria-Type I Patients. PMID:32992790
Binding Mechanism Elucidation of the Acute Respiratory Disease Causing Agent Adenovirus of Serotype 7 to Desmoglein-2. PMID:32992715
Two VHH Antibodies Neutralize Botulinum Neurotoxin E1 by Blocking Its Membrane Translocation in Host Cells. PMID:32992561
Structure and Function of the T4 Spackle Protein Gp61.3. PMID:32987925
Structural and functional modelling of SARS-CoV-2 entry in animal models. PMID:32985513
Structural Aspects of the Allergen-Antibody Interaction. PMID:32983155
Structural basis of mammalian mucin processing by the human gut O-glycopeptidase OgpA from Akkermansia muciniphila. PMID:32973204
Molecular mechanism for direct actin force-sensing by α-catenin. PMID:32969337
Biophysical and Biochemical Characterization of TP0037, a d-Lactate Dehydrogenase, Supports an Acetogenic Energy Conservation Pathway in Treponema pallidum. PMID:32963009
The structural basis for the selectivity of sulfonamido dicarbaboranes toward cancer-associated carbonic anhydrase IX. PMID:32962427
Thermodynamic Analysis of Point Mutations Inhibiting High-Temperature Reversible Oligomerization of PDZ3. PMID:32961107
Structure and function of bacteriophage CBA120 ORF211 (TSP2), the determinant of phage specificity towards E. coli O157:H7. PMID:32958885
Robust ω-Transaminases by Computational Stabilization of the Subunit Interface. PMID:32953233
Solution NMR structure of Se0862, a highly conserved cyanobacterial protein involved in biofilm formation. PMID:32949024
Structure, Folding and Stability of Nucleoside Diphosphate Kinases. PMID:32947863
Receptor binding and priming of the spike protein of SARS-CoV-2 for membrane fusion. PMID:32942285
Structural insights into the histidine-containing phospho-transfer protein and receiver domain of sensor histidine kinase suggest a complex model in the two-component regulatory system in Pseudomonas aeruginosa. PMID:32939285
DELTEX2 C-terminal domain recognizes and recruits ADP-ribosylated proteins for ubiquitination. PMID:32937373
Molecular basis of the potential interaction of SARS-CoV-2 spike protein to CD147 in COVID-19 associated-lymphopenia. PMID:32936048
Targeting SARS-CoV-2 Nsp12/Nsp8 interaction interface with approved and investigational drugs: an in silico structure-based approach. PMID:32933378
Agonist Binding and G Protein Coupling in Histamine H2 Receptor: A Molecular Dynamics Study. PMID:32932742
Cryo-EM structure of the entire mammalian F-type ATP synthase. PMID:32929284
Fibril structures of diabetes-related amylin variants reveal a basis for surface-templated assembly. PMID:32929282
Loss-of-function maternal-effect mutations of PADI6 are associated with familial and sporadic Beckwith-Wiedemann syndrome with multi-locus imprinting disturbance. PMID:32928291
X-ray crystal structure and specificity of the Toxoplasma gondii ME49 TgAPN2. PMID:32926129
Three-dimensional structure of 22 uncultured ssRNA bacteriophages: Flexibility of the coat protein fold and variations in particle shapes. PMID:32917600
Site mapping and small molecule blind docking reveal a possible target site on the SARS-CoV-2 main protease dimer interface. PMID:32911432
Allosteric regulation of lysosomal enzyme recognition by the cation-independent mannose 6-phosphate receptor. PMID:32908216
The Structure of the Cysteine-Rich Domain of Plasmodium falciparum P113 Identifies the Location of the RH5 Binding Site. PMID:32900802
Symmetry breaking and structural polymorphism in a bacterial microcompartment shell protein for choline utilization. PMID:32885887
Molecular basis for N-terminal alpha-synuclein acetylation by human NatB. PMID:32885784
The structure of the Moco carrier protein from Rippkaea orientalis. PMID:32880594
The structure of PfGH50B, an agarase from the marine bacterium Pseudoalteromonas fuliginea PS47. PMID:32880590
High-resolution structure of the alcohol dehydrogenase domain of the bifunctional bacterial enzyme AdhE. PMID:32880589
Shared structural mechanisms of general anaesthetics and benzodiazepines. PMID:32879488
Structure of Arabidopsis HISTONE DEACETYLASE15. PMID:32878973
Crystal structures of human ENPP1 in apo and bound forms. PMID:32876064
Recognition of an α-helical hairpin in P22 large terminase by a synthetic antibody fragment. PMID:32876063
Structure of SARS-CoV-2 ORF8, a rapidly evolving coronavirus protein implicated in immune evasion. PMID:32869027
Structural classification of neutralizing antibodies against the SARS-CoV-2 spike receptor-binding domain suggests vaccine and therapeutic strategies. PMID:32869026
Novel bacterial clade reveals origin of form I Rubisco. PMID:32868887
ppGpp Coordinates Nucleotide and Amino-Acid Synthesis in E. coli During Starvation. PMID:32857952
The cryoelectron microscopy structure of the human CDK-activating kinase. PMID:32855301
Functional and Structural Characterization of a Potent C1q Inhibitor Targeting the Classical Pathway of the Complement System. PMID:32849513
Structural mechanism for replication origin binding and remodeling by a metazoan origin recognition complex and its co-loader Cdc6. PMID:32848132
Calcium modulates the domain flexibility and function of an α-actinin similar to the ancestral α-actinin. PMID:32848067
Distinct oligomeric structures of the YoeB-YefM complex provide insights into the conditional cooperativity of type II toxin-antitoxin system. PMID:32845304
Cryo-EM analysis of PIP2 regulation in mammalian GIRK channels. PMID:32844743
Atomic structure of a mitochondrial complex I intermediate from vascular plants. PMID:32840211
Cryo-EM reveals the transition of Arp2/3 complex from inactive to nucleation-competent state. PMID:32839613
Ribosomal synthesis and de novo discovery of bioactive foldamer peptides containing cyclic β-amino acids. PMID:32839601
The mechanism of activation of the actin binding protein EHBP1 by Rab8 family members. PMID:32826901
Csx3 is a cyclic oligonucleotide phosphodiesterase associated with type III CRISPR-Cas that degrades the second messenger cA4. PMID:32826317
Structural Insights into the Mechanism of a Nanobody That Stabilizes PAI-1 and Modulates Its Activity. PMID:32824134
NME/NM23/NDPK and Histidine Phosphorylation. PMID:32823988
Characterization of the Corynebacterium glutamicum dehydroshikimate dehydratase QsuB and its potential for microbial production of protocatechuic acid. PMID:32822353
Structural characterization of anti-CCL5 activity of the tick salivary protein evasin-4. PMID:32817341
The cryo-EM structure of the human uromodulin filament core reveals a unique assembly mechanism. PMID:32815518
Structural analysis and reaction mechanism of the disproportionating enzyme (D-enzyme) from potato. PMID:32808707
Comprehensive analysis of IncC plasmid conjugation identifies a crucial role for the transcriptional regulator AcaB. PMID:32807890
Flowering Poration-A Synergistic Multi-Mode Antibacterial Mechanism by a Bacteriocin Fold. PMID:32795916
Cross-neutralization of a SARS-CoV-2 antibody to a functionally conserved site is mediated by avidity. PMID:32793906
Structural insights of the enzymes from the chitin utilization locus of Flavobacterium johnsoniae. PMID:32792608
Revealing the mechanism of repressor inactivation during switching of a temperate bacteriophage. PMID:32788352
Studying the Effects of ACE2 Mutations on the Stability, Dynamics, and Dissociation Process of SARS-CoV-2 S1/hACE2 Complexes. PMID:32786692
Cyanobacterial Dihydroxyacid Dehydratases Are a Promising Growth Inhibition Target. PMID:32786290
Structural basis of Focal Adhesion Kinase activation on lipid membranes. PMID:32779739
A monodomain class II terpene cyclase assembles complex isoprenoid scaffolds. PMID:32778689
Tetherin downmodulation by SIVmac Nef lost with the H196Q escape variant is restored by an upstream variant. PMID:32764749
Structures of filamentous viruses infecting hyperthermophilic archaea explain DNA stabilization in extreme environments. PMID:32759221
Immunoinformatic construction of an adenovirus-based modular vaccine platform and its application in the design of a SARS-CoV-2 vaccine. PMID:32758675
GapR binds DNA through dynamic opening of its tetrameric interface. PMID:32756896
An alternate conformation of HCV E2 neutralizing face as an additional vaccine target. PMID:32754640
Flexible NAD+ Binding in Deoxyhypusine Synthase Reflects the Dynamic Hypusine Modification of Translation Factor IF5A. PMID:32752130
Structural Characterization of an S-enantioselective Imine Reductase from Mycobacterium Smegmatis. PMID:32751900
Intrinsic curvature of the HIV-1 CA hexamer underlies capsid topology and interaction with cyclophilin A. PMID:32747784
Structural basis for carotenoid cleavage by an archaeal carotenoid dioxygenase. PMID:32747548
Orientation of immobilized antigens on common surfaces by a simple computational model: Exposition of SARS-CoV-2 Spike protein RBD epitopes. PMID:32745829
Structural and biochemical characterization of a glutathione transferase from the citrus canker pathogen Xanthomonas. PMID:32744260
Structural characterization of three noncanonical NTF2-like superfamily proteins: implications for polyketide biosynthesis. PMID:32744249
Structural analysis of a novel substrate-free form of the aminoglycoside 6'-N-acetyltransferase from Enterococcus faecium. PMID:32744248
In crystallo-screening for discovery of human norovirus 3C-like protease inhibitors. PMID:32743543
Structural basis for the neutralization of SARS-CoV-2 by an antibody from a convalescent patient. PMID:32737466
Turnip yellow mosaic virus protease binds ubiquitin suboptimally to fine-tune its deubiquitinase activity. PMID:32732284
Structural analysis of the LDL receptor-interacting FERM domain in the E3 ubiquitin ligase IDOL reveals an obscured substrate-binding site. PMID:32727844
Structural Basis and Evolution of Glycan Receptor Specificities within the Polyomavirus Family. PMID:32723915
Biophysical Characterization of Cancer-Related Carbonic Anhydrase IX. PMID:32722392
The architecture and stabilisation of flagellotropic tailed bacteriophages. PMID:32719311
The Interaction of Bovine β-Lactoglobulin with Caffeic Acid: From Binding Mechanisms to Functional Complexes. PMID:32718063
Specific targeting of IL-1β activity to CD8+ T cells allows for safe use as a vaccine adjuvant. PMID:32714571
Highly Conserved Molecular Features in IgLONs Contrast Their Distinct Structural and Biological Outcomes. PMID:32710982
Mycobacterium tuberculosis FasR senses long fatty acyl-CoA through a tunnel and a hydrophobic transmission spine. PMID:32710080
Natural Killer Cell Activation Receptor NKp30 Oligomerization Depends on Its N-Glycosylation. PMID:32708305
Side chain flexibility and the symmetry of protein homodimers. PMID:32706779
Transition-State Analogues of Phenylethanolamine N-Methyltransferase. PMID:32702980
Glypicans shield the Wnt lipid moiety to enable signalling at a distance. PMID:32699409
Modulation of Light Energy Transfer from Chromophore to Protein in the Channelrhodopsin ReaChR. PMID:32697975
Structural basis of self-assembly in the lipid-binding domain of mycobacterial polar growth factor Wag31. PMID:32695423
Induced DNA bending by unique dimerization of HigA antitoxin. PMID:32695421
Structural insights into the regulation of SigB activity by RsbV and RsbW. PMID:32695420
Crystal structure and interaction studies of human DHTKD1 provide insight into a mitochondrial megacomplex in lysine catabolism. PMID:32695416
An International Multicenter Evaluation of Inheritance Patterns, Arrhythmic Risks, and Underlying Mechanisms of CASQ2-Catecholaminergic Polymorphic Ventricular Tachycardia. PMID:32693635
Corrigendum: Pac13 is a Small Dehydratase that Mediates the Formation of the 3'-Deoxy Nucleoside of Pacidamycins. PMID:32691957
An influenza A hemagglutinin small-molecule fusion inhibitor identified by a new high-throughput fluorescence polarization screen. PMID:32690700
The structural basis for monoclonal antibody 5D2 binding to the tryptophan-rich loop of lipoprotein lipase. PMID:32690595
R-hydroxynitrile lyase from the cyanogenic millipede, Chamberlinius hualienensis-A new entry to the carrier protein family Lipocalines. PMID:32679618
PE5-PPE4-EspG3 heterotrimer structure from mycobacterial ESX-3 secretion system gives insight into cognate substrate recognition by ESX systems. PMID:32675282
The discovery of a new antibody for BRIL-fused GPCR structure determination. PMID:32669569
Structural and Biochemical Analyses Reveal that Chlorogenic Acid Inhibits the Shikimate Pathway. PMID:32661075
Structural basis of a shared antibody response to SARS-CoV-2. PMID:32661058
Inactivation of the dimeric RappLS20 anti-repressor of the conjugation operon is mediated by peptide-induced tetramerization. PMID:32658272
The Dual PDZ Domain from Postsynaptic Density Protein 95 Forms a Scaffold with Peptide Ligand. PMID:32652058
Structural basis of a novel repressor, SghR, controlling Agrobacterium infection by cross-talking to plants. PMID:32651231
Structure basis of the FERM domain of kindlin-3 in supporting integrin αIIbβ3 activation in platelets. PMID:32649767
Structural basis for differentiation between two classes of thiolase: Degradative vs biosynthetic thiolase. PMID:32647822
Addressing the Molecular Mechanism of Longitudinal Lamin Assembly Using Chimeric Fusions. PMID:32645958
Structural basis of human full-length kindlin-3 homotrimer in an auto-inhibited state. PMID:32644996
Atomic structure of the Campylobacter jejuni flagellar filament reveals how ε Proteobacteria escaped Toll-like receptor 5 surveillance. PMID:32641510
Mechanism of Astragalus membranaceus in the treatment of laryngeal cancer based on gene co-expression network and molecular docking. PMID:32636440
A redox-active switch in fructosamine-3-kinases expands the regulatory repertoire of the protein kinase superfamily. PMID:32636308
Structural and Functional Insights into the C-terminal Fragment of Insecticidal Vip3A Toxin of Bacillus thuringiensis. PMID:32635593
Inhibition and Crystal Structure of the Human DHTKD1-Thiamin Diphosphate Complex. PMID:32633484
DiB-splits: nature-guided design of a novel fluorescent labeling split system. PMID:32632329
Architecture and functional dynamics of the pentafunctional AROM complex. PMID:32632294
Structure of apo flavin-dependent halogenase Xcc4156 hints at a reason for cofactor-soaking difficulties. PMID:32627741
Extensive sequence and structural evolution of Arginase 2 inhibitory antibodies enabled by an unbiased approach to affinity maturation. PMID:32616569
Recognition Patterns of the C1/C2 Epitopes Involved in Fc-Mediated Response in HIV-1 Natural Infection and the RV114 Vaccine Trial. PMID:32605979
Evaluating the Potential for Cross-Interactions of Antitoxins in Type II TA Systems. PMID:32604745
Larger active site in an ancestral hydroxynitrile lyase increases catalytically promiscuous esterase activity. PMID:32603354
Maturation of the functional mouse CRES amyloid from globular form. PMID:32601205
Homodimerization of a glycoside hydrolase family GH1 β-glucosidase suggests distinct activity of enzyme different states. PMID:32597558
Structure and Dynamics of a Thermostable Alcohol Dehydrogenase from the Antarctic Psychrophile Moraxella sp. TAE123. PMID:32596590
Cryo-EM structures of NPC1L1 reveal mechanisms of cholesterol transport and ezetimibe inhibition. PMID:32596471
Recognition of Semaphorin Proteins by P. sordellii Lethal Toxin Reveals Principles of Receptor Specificity in Clostridial Toxins. PMID:32589945
Structural Insights into RNA Dimerization: Motifs, Interfaces and Functions. PMID:32585844
Neutralization of SARS-CoV-2 by Destruction of the Prefusion Spike. PMID:32585135
CoRNeA: A Pipeline to Decrypt the Inter-Protein Interfaces from Amino Acid Sequence Information. PMID:32580303
Structural basis of a public antibody response to SARS-CoV-2. PMID:32577642
Identification of a PGXPP degron motif in dishevelled and structural basis for its binding to the E3 ligase KLHL12. PMID:32574548
A secreted LysM effector protects fungal hyphae through chitin-dependent homodimer polymerization. PMID:32574207
Structural Characterization of TssL from Acinetobacter baumannii: a Key Component of the Type VI Secretion System. PMID:32571965
The bacterial copper resistance protein CopG contains a cysteine-bridged tetranuclear copper cluster. PMID:32571874
The Structural Basis of T4 Phage Lysis Control: DNA as the Signal for Lysis Inhibition. PMID:32562709
Targeting epigenetic protein-protein interactions with small-molecule inhibitors. PMID:32551894
The Discovery of a Putative Allosteric Site in the SARS-CoV-2 Spike Protein Using an Integrated Structural/Dynamic Approach. PMID:32551648
Structure and function of a flavin-dependent S-monooxygenase from garlic (Allium sativum). PMID:32527723
Structural basis of prostate-specific membrane antigen recognition by the A9g RNA aptamer. PMID:32525981
Human XPG nuclease structure, assembly, and activities with insights for neurodegeneration and cancer from pathogenic mutations. PMID:32522879
mRNA Interferase Bacillus cereus BC0266 Shows MazF-Like Characteristics Through Structural and Functional Study. PMID:32521689
Structural analysis of avibactam-mediated activation of the bla and mec divergons in methicillin-resistant Staphylococcus aureus. PMID:32518158
Uncovering the chemistry of C-C bond formation in C-nucleoside biosynthesis: crystal structure of a C-glycoside synthase/PRPP complex. PMID:32515440
Mechanism of effector capture and delivery by the type IV secretion system from Legionella pneumophila. PMID:32513920
Structure and mechanism of the Nap adhesion complex from the human pathogen Mycoplasma genitalium. PMID:32513917
Crystal Structure of Flagellar Export Chaperone FliS in Complex With Flagellin and HP1076 of Helicobacter pylori. PMID:32508757
Rational design of a multi-valent human papillomavirus vaccine by capsomere-hybrid co-assembly of virus-like particles. PMID:32503989
Structural basis of semaphorin-plexin cis interaction. PMID:32500924
Exploring the Molecular Basis for Substrate Affinity and Structural Stability in Bacterial GH39 β-Xylosidases. PMID:32500063
Structural and functional evidence of bacterial antiphage protection by Thoeris defense system via NAD+ degradation. PMID:32499527
Structural basis of the dominant inheritance of hypermethioninemia associated with the Arg264His mutation in the MAT1A gene. PMID:32496220
Structural analysis of the PATZ1 BTB domain homodimer. PMID:32496219
Structural studies of geranylgeranylglyceryl phosphate synthase, a prenyltransferase found in thermophilic Euryarchaeota. PMID:32496216
2.7 Å cryo-EM structure of rotavirus core protein VP3, a unique capping machine with a helicase activity. PMID:32494598
The CDK inhibitor CR8 acts as a molecular glue degrader that depletes cyclin K. PMID:32494016
A disulfide constrains the ToxR periplasmic domain structure, altering its interactions with ToxS and bile-salts. PMID:32488093
Interaction of the prototypical α-ketoamide inhibitor with the SARS-CoV-2 main protease active site in silico: Molecular dynamic simulations highlight the stability of the ligand-protein complex. PMID:32485652
These motors were made for walking. PMID:32472639
International Union of Basic and Clinical Pharmacology. CVIII. Calcium-Sensing Receptor Nomenclature, Pharmacology, and Function. PMID:32467152
Design of a surrogate Anticalin protein directed against CD98hc for preclinical studies in mice. PMID:32463547
Origin of complexity in haemoglobin evolution. PMID:32461643
Vulnerabilities in coronavirus glycan shields despite extensive glycosylation. PMID:32461612
The architecture of EMC reveals a path for membrane protein insertion. PMID:32459176
Structural Basis for Broad Substrate Selectivity of Alcohol Dehydrogenase YjgB from Escherichia coli. PMID:32455802
CryoEM structures of human CMG-ATPγS-DNA and CMG-AND-1 complexes. PMID:32453425
Molecular basis for the assembly of RuBisCO assisted by the chaperone Raf1. PMID:32451445
A possible strategy to fight COVID-19: Interfering with spike glycoprotein trimerization. PMID:32451080
Molecular Mechanism of Regulation of the Purine Salvage Enzyme XPRT by the Alarmones pppGpp, ppGpp, and pGpp. PMID:32446804
New Structural insights into Kir channel gating from molecular simulations, HDX-MS and functional studies. PMID:32439887
Structural basis for membrane insertion by the human ER membrane protein complex. PMID:32439656
CD95 Structure, Aggregation and Cell Signaling. PMID:32432115
A structural study of TatD from Staphylococcus aureus elucidates a putative DNA-binding mode of a Mg2+-dependent nuclease. PMID:32431834
Cellular and Structural Basis of Synthesis of the Unique Intermediate Dehydro-F420-0 in Mycobacteria. PMID:32430409
HPV Infection Affects Human Sperm Functionality by Inhibition of Aquaporin-8. PMID:32429588
A terminal α3-galactose modification regulates an E3 ubiquitin ligase subunit in Toxoplasma gondii. PMID:32414843
Crystal Structure and Active Site Engineering of a Halophilic γ-Carbonic Anhydrase. PMID:32411108
Structural basis for the binding of SNAREs to the multisubunit tethering complex Dsl1. PMID:32409579
Legionella effector MavC targets the Ube2N~Ub conjugate for noncanonical ubiquitination. PMID:32398758
Structural and functional insights into oligopeptide acquisition by the RagAB transporter from Porphyromonas gingivalis. PMID:32393857
AlloSigMA 2: paving the way to designing allosteric effectors and to exploring allosteric effects of mutations. PMID:32392302
Structure-function analysis of silkworm sucrose hydrolase uncovers the mechanism of substrate specificity in GH13 subfamily 17 exo-α-glucosidases. PMID:32381508
Crystal structures of the RNA triphosphatase from Trypanosoma cruzi provide insights into how it recognizes the 5'-end of the RNA substrate. PMID:32381506
Diversity in kinetics correlated with structure in nano body-stabilized LacY. PMID:32380514
Coiled-coil registry shifts in the F684I mutant of Bicaudal D result in cargo-independent activation of dynein motility. PMID:32378283
Structural basis for the complex DNA binding behavior of the plant stem cell regulator WUSCHEL. PMID:32376862
Cryo-EM Structure of the Fork Protection Complex Bound to CMG at a Replication Fork. PMID:32369734
RIM-binding protein couples synaptic vesicle recruitment to release sites. PMID:32369542
Mutation-Associated Phenotypic Heterogeneity in Novel and Canonical PIK3CA Helical and Kinase Domain Mutants. PMID:32365913
Nanogel receptors for high isoelectric point protein detection: influence of electrostatic and covalent polymer-protein interactions. PMID:32364214
Structural basis for the hydrolytic dehalogenation of the fungicide chlorothalonil. PMID:32358058
Molecular basis of MKLP2-dependent Aurora B transport from chromatin to the anaphase central spindle. PMID:32356865
Crystal structure of gluconate 5-dehydrogenase from Lentibacter algarum. PMID:32356525
Crystallographic snapshots of the EF-hand protein MCFD2 complexed with the intracellular lectin ERGIC-53 involved in glycoprotein transport. PMID:32356523
Structural basis for loading and inhibition of a bacterial T6SS phospholipase effector by the VgrG spike. PMID:32350888
Structural Determination of a Filamentous Chaperone to Fabricate Electronically Conductive Metalloprotein Nanowires. PMID:32347705
The DNA Sensor cGAS is Decorated by Acetylation and Phosphorylation Modifications in the Context of Immune Signaling. PMID:32345711
FGCaMP7, an Improved Version of Fungi-Based Ratiometric Calcium Indicator for In Vivo Visualization of Neuronal Activity. PMID:32344594
Comparative Structural Analysis of 20S Proteasome Ortholog Protein Complexes by Native Mass Spectrometry. PMID:32342007
Molecular basis for assembly of the shieldin complex and its implications for NHEJ. PMID:32332881
The structure of helical lipoprotein lipase reveals an unexpected twist in lipase storage. PMID:32332168
The structure of the extracellular domains of human interleukin 11α receptor reveals mechanisms of cytokine engagement. PMID:32332100
Structural basis for Zika envelope domain III recognition by a germline version of a recurrent neutralizing antibody. PMID:32321830
MiR193a Modulation and Podocyte Phenotype. PMID:32316697
NusA directly interacts with antitermination factor Q from phage λ. PMID:32313022
From conservation to structure, studies of magnetosome associated cation diffusion facilitators (CDF) proteins in Proteobacteria. PMID:32310978
Expression of quasi-equivalence and capsid dimorphism in the Hepadnaviridae. PMID:32310951
Crystal structure of Nsp15 endoribonuclease NendoU from SARS-CoV-2. PMID:32304108
Revisiting high-resolution crystal structure of Phormidium rubidum phycocyanin. PMID:32303893
Pyrethroid Carboxylesterase PytH from Sphingobium faniae JZ-2: Structure and Catalytic Mechanism. PMID:32303545
SpeG polyamine acetyltransferase enzyme from Bacillus thuringiensis forms a dodecameric structure and exhibits high catalytic efficiency. PMID:32283314
Structure of the Native Muscle-type Nicotinic Receptor and Inhibition by Snake Venom Toxins. PMID:32275860
Crystal structures of REF6 and its complex with DNA reveal diverse recognition mechanisms. PMID:32257379
The quaternary assembly of KRas4B with Raf-1 at the membrane. PMID:32257057
Structural characterization of human O-phosphoethanolamine phospho-lyase. PMID:32254049
Crystallographic and kinetic analyses of the FdsBG subcomplex of the cytosolic formate dehydrogenase FdsABG from Cupriavidus necator. PMID:32249211
A knowledge-based scoring function to assess quaternary associations of proteins. PMID:32246820
A highly conserved cryptic epitope in the receptor binding domains of SARS-CoV-2 and SARS-CoV. PMID:32245784
Structural Basis for the Asymmetry of a 4-Oxalocrotonate Tautomerase Trimer. PMID:32242662
An integrated approach to unravel a crucial structural property required for the function of the insect steroidogenic Halloween protein Noppera-bo. PMID:32241910
X-ray crystal structure localizes the mechanism of inhibition of an IL-36R antagonist monoclonal antibody to interaction with Ig1 and Ig2 extra cellular domains. PMID:32239732
Molecular basis of ALK1-mediated signalling by BMP9/BMP10 and their prodomain-bound forms. PMID:32238803
Half Way to Hypusine-Structural Basis for Substrate Recognition by Human Deoxyhypusine Synthase. PMID:32235505
Identification of MLKL membrane translocation as a checkpoint in necroptotic cell death using Monobodies. PMID:32234780
Dynamics in the murine norovirus capsid revealed by high-resolution cryo-EM. PMID:32231352
In silico analysis of the structural diversity and interactions between invertases and invertase inhibitors from potato (Solanum tuberosum L.). PMID:32226707
Structural Basis for How Biologic Medicines Bind their Targets in Psoriasis Therapy. PMID:32226331
Structural basis for substrate and product recognition in human phosphoglucomutase-1 (PGM1) isoform 2, a member of the α-D-phosphohexomutase superfamily. PMID:32221390
Synthetic antibodies against BRIL as universal fiducial marks for single-particle cryoEM structure determination of membrane proteins. PMID:32221310
Antigen-Induced Allosteric Changes in a Human IgG1 Fc Increase Low-Affinity Fcγ Receptor Binding. PMID:32209433
The cryo-EM structure of the SNX-BAR Mvp1 tetramer. PMID:32198400
Molecular dissection of pheromone selectivity in the competence signaling system ComRS of streptococci. PMID:32198205
Structural and mutational analyses of the bifunctional arginine dihydrolase and ornithine cyclodeaminase AgrE from the cyanobacterium Anabaena. PMID:32198136
Drosophila OTK Is a Glycosaminoglycan-Binding Protein with High Conformational Flexibility. PMID:32187531
Binding Options for the Small Subunit-Like Domain of Cyanobacteria to Rubisco. PMID:32180764
Structural and functional insights into a novel two-component endolysin encoded by a single gene in Enterococcus faecalis phage. PMID:32176738
Crystal Structure of the Chloroplastic Glutamine Phosphoribosylpyrophosphate Amidotransferase GPRAT2 From Arabidopsis thaliana. PMID:32174940
Sjögren syndrome/scleroderma autoantigen 1 is a direct Tankyrase binding partner in cancer cells. PMID:32170109
Crystal Structure of α-Xylosidase from Aspergillus niger in Complex with a Hydrolyzed Xyloglucan Product and New Insights in Accurately Predicting Substrate Specificities of GH31 Family Glycosidases. PMID:32161692
Stepwise Promoter Melting by Bacterial RNA Polymerase. PMID:32160514
A bifunctional O-antigen polymerase structure reveals a new glycosyltransferase family. PMID:32152541
Neighborhood Preference of Amino Acids in Protein Structures and its Applications in Protein Structure Assessment. PMID:32152349
Full-length human GLP-1 receptor structure without orthosteric ligands. PMID:32152292
Structural model for differential cap maturation at growing microtubule ends. PMID:32151315
Structure of mouse coronavirus spike protein complexed with receptor reveals mechanism for viral entry. PMID:32150576
Structure of the MICU1-MICU2 heterodimer provides insights into the gatekeeping threshold shift. PMID:32148862
ClusPro in rounds 38 to 45 of CAPRI: Toward combining template-based methods with free docking. PMID:32142178
Crystal structures of human NSDHL and development of its novel inhibitor with the potential to suppress EGFR activity. PMID:32140747
RPTPα phosphatase activity is allosterically regulated by the membrane-distal catalytic domain. PMID:32139509
Engineering the Fab fragment of the anti-IgE omalizumab to prevent Fab crystallization and permit IgE-Fc complex crystallization. PMID:32133997
Structural and biochemical characterization of mitochondrial citrate synthase 4 from Arabidopsis thaliana. PMID:32133996
A practical overview of molecular replacement: Clostridioides difficile PilA1, a difficult case study. PMID:32133990
An ultralong CDRH2 in HCV neutralizing antibody demonstrates structural plasticity of antibodies against E2 glycoprotein. PMID:32125272
Cryo-EM structures reveal translocational unfolding in the clostridial binary iota toxin complex. PMID:32123390
Multivalent interactions between CsoS2 and Rubisco mediate α-carboxysome formation. PMID:32123388
Structural elucidation of the Clostridioides difficile transferase toxin reveals a single-site binding mode for the enzyme. PMID:32123082
N-terminal Backbone Pairing Shifts in CCL5-12AAA14 Dimer Interface: Structural Significance of the FAY Sequence. PMID:32121575
Novel Genetically Encoded Bright Positive Calcium Indicator NCaMP7 Based on the mNeonGreen Fluorescent Protein. PMID:32121243
Structural analyses of the Group A flavin-dependent monooxygenase PieE reveal a sliding FAD cofactor conformation bridging OUT and IN conformations. PMID:32111738
Structural basis of cell-surface signaling by a conserved sigma regulator in Gram-negative bacteria. PMID:32107313
Family-wide Structural and Biophysical Analysis of Binding Interactions among Non-clustered δ-Protocadherins. PMID:32101743
Structural Insights into Rational Design of Single-Domain Antibody-Based Antitoxins against Botulinum Neurotoxins. PMID:32101733
Marked structural rearrangement of mannose 6-phosphate/IGF2 receptor at different pH environments. PMID:32095534
Trinuclear copper biocatalytic center forms an active site of thiocyanate dehydrogenase. PMID:32094184
Massively parallel variant characterization identifies NUDT15 alleles associated with thiopurine toxicity. PMID:32094176
Model Reconstruction from Small-Angle X-Ray Scattering Data Using Deep Learning Methods. PMID:32092702
Cryo-EM structure of the Shigella type III needle complex. PMID:32092125
Conformation-specific inhibitors of activated Ras GTPases reveal limited Ras dependency of patient-derived cancer organoids. PMID:32086379
Conditional Disorder in Small Heat-shock Proteins. PMID:32081587
Neutralization Mechanism of a Monoclonal Antibody Targeting a Porcine Circovirus Type 2 Cap Protein Conformational Epitope. PMID:32075932
Helicase of Type 2 Porcine Reproductive and Respiratory Syndrome Virus Strain HV Reveals a Unique Structure. PMID:32075207
Restricted epitope specificity determined by variable region germline segment pairing in rodent antibody repertoires. PMID:32041466
High-resolution crystal structures of Escherichia coli FtsZ bound to GDP and GTP. PMID:32039891
3D domain swapping in the TIM barrel of the α subunit of Streptococcus pneumoniae tryptophan synthase. PMID:32038047
An Acetylation Switch of the NLRP3 Inflammasome Regulates Aging-Associated Chronic Inflammation and Insulin Resistance. PMID:32032542
Posttranslational Modifications Mediate the Structural Diversity of Tauopathy Strains. PMID:32032505
ProtCID: a data resource for structural information on protein interactions. PMID:32024829
Crystal structure of thioredoxin 1 from Cryptococcus neoformans at 1.8 Å resolution shows unexpected plasticity of the loop preceding the catalytic site. PMID:32021910
Probing the mutational landscape of regulators of G protein signaling proteins in cancer. PMID:32019900
Differential Features of Fusion Activation within the Paramyxoviridae. PMID:32019182
Potent Zika and dengue cross-neutralizing antibodies induced by Zika vaccination in a dengue-experienced donor. PMID:32015557
Recognition and Activation of the Plant AKT1 Potassium Channel by the Kinase CIPK23. PMID:32015077
A thermophilic phage uses a small terminase protein with a fixed helix-turn-helix geometry. PMID:32014998
Identification of New Peptides from Fermented Milk Showing Antioxidant Properties: Mechanism of Action. PMID:32013158
Structural insights into selective interaction between type IIa receptor protein tyrosine phosphatases and Liprin-α. PMID:32005855
Restriction of HIV-1 Escape by a Highly Broad and Potent Neutralizing Antibody. PMID:32004464
Structure of the prefusion-locking broadly neutralizing antibody RVC20 bound to the rabies virus glycoprotein. PMID:32001700
HIV vaccine delayed boosting increases Env variable region 2-specific antibody effector functions. PMID:31996483
Structure-Function Analyses of a Keratin Heterotypic Complex Identify Specific Keratin Regions Involved in Intermediate Filament Assembly. PMID:31995743
Crystal structure of PMGL2 esterase from the hormone-sensitive lipase family with GCSAG motif around the catalytic serine. PMID:31990908
Consensus protein engineering on the thermostable histone-like bacterial protein HUs significantly improves stability and DNA binding affinity. PMID:31980943
Higher-order oligomerization of a chimeric αβγ bifunctional diterpene synthase with prenyltransferase and class II cyclase activities is concentration-dependent. PMID:31978464
Structural basis of p62/SQSTM1 helical filaments and their role in cellular cargo uptake. PMID:31974402
Structure-function analyses of alkylhydroperoxidase D from Streptococcus pneumoniae reveal an unusual three-cysteine active site architecture. PMID:31974167
Structural Analyses on the Deamidation of N-Terminal Asn in the Human N-Degron Pathway. PMID:31968674
Molecular mechanism for the recognition of sequence-divergent CIF peptides by the plant receptor kinases GSO1/SGN3 and GSO2. PMID:31964818
Structure of the human BBSome core complex. PMID:31951201
Structure-based mechanism of cysteine-switch latency and of catalysis by pappalysin-family metallopeptidases. PMID:31949901
Crystal structures of fukutin-related protein (FKRP), a ribitol-phosphate transferase related to muscular dystrophy. PMID:31949166
The basis for non-canonical ROK family function in the N-acetylmannosamine kinase from the pathogen Staphylococcus aureus. PMID:31949045
Hup-Type Hydrogenases of Purple Bacteria: Homology Modeling and Computational Assessment of Biotechnological Potential. PMID:31935912
Structural and Biophysical Analyses of Human N-Myc Downstream-Regulated Gene 3 (NDRG3) Protein. PMID:31935861
Quaternary Structure of the Tryptophan Synthase α-Subunit Homolog BX1 from Zea mays. PMID:31933363
Structure and Mechanism of a Cyclic Trinucleotide-Activated Bacterial Endonuclease Mediating Bacteriophage Immunity. PMID:31932164
The gastrointestinal pathogen Campylobacter jejuni metabolizes sugars with potential help from commensal Bacteroides vulgatus. PMID:31925306
Beyond the heterodimer model for mineralocorticoid and glucocorticoid receptor interactions in nuclei and at DNA. PMID:31923266
Crystal structures of Triosephosphate Isomerases from Taenia solium and Schistosoma mansoni provide insights for vaccine rationale and drug design against helminth parasites. PMID:31923219
Structural Basis of the Substrate Selectivity of Viperin. PMID:31917549
Partial Characterization of Two Cathepsin D Family Aspartic Peptidases of Clonorchis sinensis. PMID:31914521
Casposase structure and the mechanistic link between DNA transposition and spacer acquisition by CRISPR-Cas. PMID:31913120
The Trp triad within the V-domain of the receptor for advanced glycation end products modulates folding, stability and ligand binding. PMID:31912881
Different ways to transport ammonia in human and Mycobacterium tuberculosis NAD+ synthetases. PMID:31911602
Hand-foot-and-mouth disease virus receptor KREMEN1 binds the canyon of Coxsackie Virus A10. PMID:31911601
A bipartite structural organization defines the SERINC family of HIV-1 restriction factors. PMID:31907454
The bacterial deubiquitinase Ceg23 regulates the association of Lys-63-linked polyubiquitin molecules on the Legionella phagosome. PMID:31907282
The Biosynthesis of the Benzoxazole in Nataxazole Proceeds via an Unstable Ester and has Synthetic Utility. PMID:31903677
Versatile and robust genome editing with Streptococcus thermophilus CRISPR1-Cas9. PMID:31900288
Crystal Structure and Immunogenicity of the DS-Cav1-Stabilized Fusion Glycoprotein From Respiratory Syncytial Virus Subtype B. PMID:31893251
Passenger sequences can promote interlaced dimers in a common variant of the maltose-binding protein. PMID:31892719
Crystal structures of p120RasGAP N-terminal SH2 domain in its apo form and in complex with a p190RhoGAP phosphotyrosine peptide. PMID:31891593
Structural characterization of aminoglycoside 4'-O-adenylyltransferase ANT(4')-IIb from Pseudomonas aeruginosa. PMID:31891426
Structural analysis of mycobacterial homoserine transacetylases central to methionine biosynthesis reveals druggable active site. PMID:31889085
Structural insights into phosphopantetheinyl hydrolase PptH from Mycobacterium tuberculosis. PMID:31886928
Fulditoxin, representing a new class of dimeric snake toxins, defines novel pharmacology at nicotinic ACh receptors. PMID:31877243
Catalytic Cycle of Glycoside Hydrolase BglX from Pseudomonas aeruginosa and Its Implications for Biofilm Formation. PMID:31877028
Structural and mechanistic aspects of carotenoid cleavage dioxygenases (CCDs). PMID:31874225
An inhibitor of complement C5 provides structural insights into activation. PMID:31871188
X-ray crystallographic structure of BshB, the zinc-dependent deacetylase involved in bacillithiol biosynthesis. PMID:31867856
A key region of molecular specificity orchestrates unique ephrin-B1 utilization by Cedar virus. PMID:31862858
Molecular mechanism of two nanobodies that inhibit PAI-1 activity reveals a modulation at distinct stages of the PAI-1/plasminogen activator interaction. PMID:31858714
The structure of the periplasmic FlaG-FlaF complex and its essential role for archaellar swimming motility. PMID:31844299
The CC' loop of IgV domains of the immune checkpoint receptors, plays a key role in receptor:ligand affinity modulation. PMID:31844079
Structural Insights into the Intracellular Region of the Human Magnesium Transport Mediator CNNM4. PMID:31842432
Structural evidence for the critical role of the prion protein hydrophobic region in forming an infectious prion. PMID:31815959
Molecular basis for GTP recognition by light-activated guanylate cyclase RhGC. PMID:31808997
Molecular characterization of a Trichinella spiralis enolase and its interaction with the host's plasminogen. PMID:31806006
Crystal structure of the translation recovery factor Trf from Sulfolobus solfataricus. PMID:31804766
Evolutionary Dynamics of Oropouche Virus in South America. PMID:31801869
Structural basis for the dimerization of Gemin5 and its role in protein recruitment and translation control. PMID:31799608
A Conserved Regulatory Circuit Controls Large Adhesins in Vibrio cholerae. PMID:31796544
Asymmetric opening of HIV-1 Env bound to CD4 and a coreceptor-mimicking antibody. PMID:31792452
Structures of MERS-CoV spike glycoprotein in complex with sialoside attachment receptors. PMID:31792450
Mechanism of conditional partner selectivity in MITF/TFE family transcription factors with a conserved coiled coil stammer motif. PMID:31777941
Evolution-guided engineering of small-molecule biosensors. PMID:31777933
Boosting with AIDSVAX B/E Enhances Env Constant Region 1 and 2 Antibody-Dependent Cellular Cytotoxicity Breadth and Potency. PMID:31776278
Energetic dependencies dictate folding mechanism in a complex protein. PMID:31776255
Structure of Staphylococcal Enterotoxin N: Implications for Binding Properties to Its Cellular Proteins. PMID:31775346
Characterization of Antigenic MHC-Class-I-Restricted T Cell Epitopes in the Glycoprotein of Ebolavirus. PMID:31775024
A structural basis for antibody-mediated neutralization of Nipah virus reveals a site of vulnerability at the fusion glycoprotein apex. PMID:31767754
Synthetic Antibody Binding to a Preorganized RNA Domain of Hepatitis C Virus Internal Ribosome Entry Site Inhibits Translation. PMID:31765566
Enhanced Characterization of Membrane Protein Complexes by Ultraviolet Photodissociation Mass Spectrometry. PMID:31765130
Structural and functional characterization of three Type B and C chloramphenicol acetyltransferases from Vibrio species. PMID:31762145
Structural insights into substrate recognition by the type VII secretion system. PMID:31758528
Structural and biochemical analysis of Bacillus anthracis prephenate dehydrogenase reveals an unusual mode of inhibition by tyrosine via the ACT domain. PMID:31750992
Cryo-EM Structure of Nucleotide-Bound Tel1ATM Unravels the Molecular Basis of Inhibition and Structural Rationale for Disease-Associated Mutations. PMID:31740029
Structural insights into a HECT-type E3 ligase AREL1 and its ubiquitination activities in vitro. PMID:31732561
'Drc', a structurally novel ssDNA-binding transcription regulator of N4-related bacterial viruses. PMID:31724707
Structural basis of binding of homodimers of the nuclear receptor NR4A2 to selective Nur-responsive DNA elements. PMID:31723028
Whole exome sequencing identifies a novel SCN1A mutation in genetic (idiopathic) generalized epilepsy and juvenile myoclonic epilepsy subtypes. PMID:31720899
Alterations in plasma membrane ion channel structures stimulate NLRP3 inflammasome activation in APOL1 risk milieu. PMID:31714001
Structures of MERS1, the 5' processing enzyme of mitochondrial mRNAs in Trypanosoma brucei. PMID:31704716
The non-swapped monomeric structure of the arginine-binding protein from Thermotoga maritima. PMID:31702584
Streptococcal phosphotransferase system imports unsaturated hyaluronan disaccharide derived from host extracellular matrices. PMID:31697725
Structural mechanism for regulation of DNA binding of BpsR, a Bordetella regulator of biofilm formation, by 6-hydroxynicotinic acid. PMID:31697703
An engineered antibody fragment targeting mutant β-catenin via major histocompatibility complex I neoantigen presentation. PMID:31690625
Crystal Structure Of Photorespiratory Alanine:Glyoxylate Aminotransferase 1 (AGT1) From Arabidopsis thaliana. PMID:31681359
Atomic Structure of the Francisella T6SS Central Spike Reveals a Unique α-Helical Lid and a Putative Cargo. PMID:31677891
The mechanosensitive ion channel TRAAK is localized to the mammalian node of Ranvier. PMID:31674909
A generalized HIV vaccine design strategy for priming of broadly neutralizing antibody responses. PMID:31672916
Development of "Plug and Play" Fiducial Marks for Structural Studies of GPCR Signaling Complexes by Single-Particle Cryo-EM. PMID:31669042
Structural and thermodynamic basis for the recognition of the substrate-binding cleft on hen egg lysozyme by a single-domain antibody. PMID:31664051
Structural comparisons of phosphoenolpyruvate carboxykinases reveal the evolutionary trajectories of these phosphodiester energy conversion enzymes. PMID:31662435
Deciphering the Structural Basis of High Thermostability of Dehalogenase from Psychrophilic Bacterium Marinobacter sp. ELB17. PMID:31661858
ATXN1 N-terminal region explains the binding differences of wild-type and expanded forms. PMID:31655597
Crystal structure of the catalytic unit of GH 87-type α-1,3-glucanase Agl-KA from Bacillus circulans. PMID:31653959
Insights revealed by the co-crystal structure of the Saccharomyces cerevisiae histidine phosphotransfer protein Ypd1 and the receiver domain of its downstream response regulator Ssk1. PMID:31642125
Structure and Dynamics of a Site-Specific Labeled Fc Fragment with Altered Effector Functions. PMID:31640157
Structural insight into human N6amt1-Trm112 complex functioning as a protein methyltransferase. PMID:31636962
The wild-type flagellar filament of the Firmicute Kurthia at 2.8 Å resolution in vivo. PMID:31628388
Cryo-EM Structure of Actin Filaments from Zea mays Pollen. PMID:31628168
Staphylococcus aureus evasion proteins EapH1 and EapH2: Residue-level investigation of an alternative binding motif for human neutrophil elastase. PMID:31622584
Conservation of Atypical Allostery in C. elegans UDP-Glucose Dehydrogenase. PMID:31616809
Crystal Structure-Based Exploration of Arginine-Containing Peptide Binding in the ADP-Ribosyltransferase Domain of the Type III Effector XopAI Protein. PMID:31615004
Hinge Region in DNA Packaging Terminase pUL15 of Herpes Simplex Virus: A Potential Allosteric Target for Antiviral Drugs. PMID:31614784
Blind prediction of homo- and hetero-protein complexes: The CASP13-CAPRI experiment. PMID:31612567
How metal cofactors drive dimer-dodecamer transition of the M42 aminopeptidase TmPep1050 of Thermotoga maritima. PMID:31611236
The C-terminal region of human plasma fetuin-B is dispensable for the raised-elephant-trunk mechanism of inhibition of astacin metallopeptidases. PMID:31604990
Structural basis for substrate specificity and regulation of nucleotide sugar transporters in the lipid bilayer. PMID:31604945
Crystal structure of ErmE - 23S rRNA methyltransferase in macrolide resistance. PMID:31601908
Oligomer Model of PB1 Domain of p62/SQSTM1 Based on Crystal Structure of Homo-Dimer and Calculation of Helical Characteristics. PMID:31600867
Deciphering the activation and recognition mechanisms of Staphylococcus aureus response regulator ArlR. PMID:31598698
Molecular analysis of an enigmatic Streptococcus pneumoniae virulence factor: The raffinose-family oligosaccharide utilization system. PMID:31591266
A structure-based rationale for sialic acid independent host-cell entry of Sosuga virus. PMID:31591233
Structural comparison of protiated, H/D-exchanged and deuterated human carbonic anhydrase IX. PMID:31588921
Structure of tRNA methyltransferase complex of Trm7 and Trm734 reveals a novel binding interface for tRNA recognition. PMID:31586407
Recognition and processing of branched DNA substrates by Slx1-Slx4 nuclease. PMID:31584081
Structural characterization of a prolyl aminodipeptidase (PepX) from Lactobacillus helveticus. PMID:31584010
Identification of an adhesive interface for the non-clustered δ1 protocadherin-1 involved in respiratory diseases. PMID:31583286
The DRS-AIMP2-EPRS subcomplex acts as a pivot in the multi-tRNA synthetase complex. PMID:31576228
Structural insights into stressosome assembly. PMID:31576226
Structural basis of light-induced redox regulation in the Calvin-Benson cycle in cyanobacteria. PMID:31570616
Crystal Structure of Kluyveromyces lactis Glucokinase (KlGlk1). PMID:31569356
Structures of neurexophilin-neurexin complexes reveal a regulatory mechanism of alternative splicing. PMID:31566781
The Crystal Structure of Dph2 in Complex with Elongation Factor 2 Reveals the Structural Basis for the First Step of Diphthamide Biosynthesis. PMID:31566354
Structural Definition of a Neutralization-Sensitive Epitope on the MERS-CoV S1-NTD. PMID:31553909
Evolution of (p)ppGpp-HPRT regulation through diversification of an allosteric oligomeric interaction. PMID:31552824
Potent antibody lineage against malaria transmission elicited by human vaccination with Pfs25. PMID:31551421
Identification of Aethina tumida Kir Channels as Putative Targets of the Bee Venom Peptide Tertiapin Using Structure-Based Virtual Screening Methods. PMID:31546848
Molecular Origins of Functional Diversity in Benzylisoquinoline Alkaloid Methyltransferases. PMID:31543888
New Functional Ingredients Based on Microencapsulation of Aqueous Anthocyanin-Rich Extracts Derived from Black Rice (Oryza sativa L.). PMID:31540422
Structure-Function Studies of the Bacillus subtilis Ric Proteins Identify the Fe-S Cluster-Ligating Residues and Their Roles in Development and RNA Processing. PMID:31530674
Structural and functional aspects of mannuronic acid-specific PL6 alginate lyase from the human gut microbe Bacteroides cellulosilyticus. PMID:31530640
Structures in Tetrahydrofolate Methylation in Desulfitobacterial Glycine Betaine Metabolism at Atomic Resolution. PMID:31518049
Structural and functional characterization of the mitochondrial complex IV assembly factor Coa6. PMID:31515291
Molecular basis for the function of the αβ heterodimer of human NAD-dependent isocitrate dehydrogenase. PMID:31515270
Structural Basis for Properdin Oligomerization and Convertase Stimulation in the Human Complement System. PMID:31507604
Structural and functional insight into the Mycobacterium tuberculosis protein PrpR reveals a novel type of transcription factor. PMID:31504787
Dimeric structures of quinol-dependent nitric oxide reductases (qNORs) revealed by cryo-electron microscopy. PMID:31489376
An aldo-keto reductase with 2-keto-l-gulonate reductase activity functions in l-tartaric acid biosynthesis from vitamin C in Vitis vinifera. PMID:31488549
Molecular basis for retinol binding by serum amyloid A during infection. PMID:31484771
Structural basis for transcription activation by Crl through tethering of σS and RNA polymerase. PMID:31484766
Evolutionary plasticity in the allosteric regulator-binding site of pyruvate kinase isoform PykA from Pseudomonas aeruginosa. PMID:31484721
Structural basis for the substrate recognition of aminoglycoside 7''-phosphotransferase-Ia from Streptomyces hygroscopicus. PMID:31475927
A Structure-Informed Atlas of Human-Virus Interactions. PMID:31474372
Accurate Classification of Biological and non-Biological Interfaces in Protein Crystal Structures using Subtle Covariation Signals. PMID:31471543
Crystal structure of L-aspartate aminotransferase from Schizosaccharomyces pombe. PMID:31465495
Structural analysis of the recognition of the -35 promoter element by SigW from Bacillus subtilis. PMID:31461489
Structural and biochemical studies of an NB-ARC domain from a plant NLR immune receptor. PMID:31461469
Biochemical Characterization of the α-l-Rhamnosidase DtRha from Dictyoglomus thermophilum: Application to the Selective Derhamnosylation of Natural Flavonoids. PMID:31459445
Insights into the ZIKV NS1 Virology from Different Strains through a Fine Analysis of Physicochemical Properties. PMID:31458257
Making Monomeric Aquaporin Z by Disrupting the Hydrophobic Tetramer Interface. PMID:31457635
Dynamic tuning of FRET in a green fluorescent protein biosensor. PMID:31457088
Specific inter-domain interactions stabilize a compact HIV-1 Gag conformation. PMID:31437199
Heparan sulfates are critical regulators of the inhibitory megakaryocyte-platelet receptor G6b-B. PMID:31436532
Claudin-9 structures reveal mechanism for toxin-induced gut barrier breakdown. PMID:31434788
Structural Basis of Glycerophosphodiester Recognition by the Mycobacterium tuberculosis Substrate-Binding Protein UgpB. PMID:31433162
Temperature-Dependent Interactions Explain Normal and Inverted Solubility in a γD-Crystallin Mutant. PMID:31422822
Diversity of oligomerization in Drosophila semaphorins suggests a mechanism of functional fine-tuning. PMID:31417095
The structure of a polygamous repressor reveals how phage-inducible chromosomal islands spread in nature. PMID:31417084
A head-to-toe dimerization has physiological relevance for ligand-induced inactivation of protein tyrosine receptor type Z. PMID:31416834
Structure and DNA damage-dependent derepression mechanism for the XRE family member DG-DdrO. PMID:31410466
The neuraminidase of A(H3N2) influenza viruses circulating since 2016 is antigenically distinct from the A/Hong Kong/4801/2014 vaccine strain. PMID:31406333
A conserved RNA structural motif for organizing topology within picornaviral internal ribosome entry sites. PMID:31399592
High-resolution crystal structure of arthropod Eiger TNF suggests a mode of receptor engagement and altered surface charge within endosomes. PMID:31396573
ANO5 mutations in the Polish limb girdle muscular dystrophy patients: Effects on the protein structure. PMID:31395899
Structure-function studies of tetrahydroprotoberberine N-methyltransferase reveal the molecular basis of stereoselective substrate recognition. PMID:31395658
Cryo-EM structure of the activated RET signaling complex reveals the importance of its cysteine-rich domain. PMID:31392261
A strategy for the selection of monovalent antibodies that span protein dimer interfaces. PMID:31387945
Atomic structures of an entire contractile injection system in both the extended and contracted states. PMID:31384001
Structure functional insights into calcium binding during the activation of coagulation factor XIII A. PMID:31383913
Detecting and Characterizing Protein Self-Assembly In Vivo by Flow Cytometry. PMID:31380843
Predicting Specificities Under the Non-self Gametophytic Self-Incompatibility Recognition Model. PMID:31379893
Structural basis for broad substrate specificity of UDP-glucose 4-epimerase in the human milk oligosaccharide catabolic pathway of Bifidobacterium longum. PMID:31366978
Structures of CENP-C cupin domains at regional centromeres reveal unique patterns of dimerization and recruitment functions for the inner pocket. PMID:31366733
Distinct Fcα receptor N-glycans modulate the binding affinity to immunoglobulin A (IgA) antibodies. PMID:31362986
Antibody Lineages with Vaccine-Induced Antigen-Binding Hotspots Develop Broad HIV Neutralization. PMID:31348886
Bile Salts Alter the Mouse Norovirus Capsid Conformation: Possible Implications for Cell Attachment and Immune Evasion. PMID:31341042
Perturbation of the interactions of calmodulin with GRK5 using a natural product chemical probe. PMID:31337679
Underlying molecular alterations in human dihydrolipoamide dehydrogenase deficiency revealed by structural analyses of disease-causing enzyme variants. PMID:31334547
Structural basis for stereoselective dehydration and hydrogen-bonding catalysis by the SAM-dependent pericyclase LepI. PMID:31332284
The AAA + ATPase TorsinA polymerizes into hollow helical tubes with 8.5 subunits per turn. PMID:31332180
Regulation of phosphoribosyl ubiquitination by a calmodulin-dependent glutamylase. PMID:31330531
Comparative structural and thermal stability studies of Cuc m 2.0101, Art v 4.0101 and other allergenic profilins. PMID:31326654
Hydrophobic recognition allows the glycosyltransferase UGT76G1 to catalyze its substrate in two orientations. PMID:31324778
Structures of three ependymin-related proteins suggest their function as a hydrophobic molecule binder. PMID:31316816
The structural characterization of a glucosylglycerate hydrolase provides insights into the molecular mechanism of mycobacterial recovery from nitrogen starvation. PMID:31316802
Inactivating mutations and X-ray crystal structure of the tumor suppressor OPCML reveal cancer-associated functions. PMID:31316070
Phosphite binding by the HtxB periplasmic binding protein depends on the protonation state of the ligand. PMID:31308436
Structures of single-layer β-sheet proteins evolved from β-hairpin repeats. PMID:31306512
Alternative conformations of a major antigenic site on RSV F. PMID:31306469
Molecular basis of egg coat cross-linking sheds light on ZP1-associated female infertility. PMID:31300655
Structural underpinnings of Ric8A function as a G-protein α-subunit chaperone and guanine-nucleotide exchange factor. PMID:31300652
Characterization of two putative Dichelobacter nodosus footrot vaccine antigens identifies the first lysozyme inhibitor in the genus. PMID:31296905
Structural basis of NKT cell inhibition using the T-cell receptor-blocking anti-CD1d antibody 1B1. PMID:31296659
Distinct RNA-binding modules in a single PUF protein cooperate to determine RNA specificity. PMID:31294800
Crystal structure, epitope, and functional impact of an antibody against a superactive FVIIa provide insights into allosteric mechanism. PMID:31294329
Residue Mutations in Murine Herpesvirus 68 Immunomodulatory Protein M3 Reveal Specific Modulation of Chemokine Binding. PMID:31293981
Structure and assembly of the mitochondrial membrane remodelling GTPase Mgm1. PMID:31292547
Multiple Pleomorphic Tetramers of Thermostable Direct Hemolysin from Grimontia hollisae in Exerting Hemolysis and Membrane Binding. PMID:31285470
Structural Determinants for Substrate Selectivity in Guanine Deaminase Enzymes of the Amidohydrolase Superfamily. PMID:31283204
Structural insights into the substrate specificity of SP_0149, the substrate-binding protein of a methionine ABC transporter from Streptococcus pneumoniae. PMID:31282873
Crystal structure of (S)-3-O-geranylgeranylglyceryl phosphate synthase from Thermoplasma acidophilum in complex with the substrate sn-glycerol 1-phosphate. PMID:31282866
Structural Basis for Recruitment of DAPK1 to the KLHL20 E3 Ligase. PMID:31279627
The CspC pseudoprotease regulates germination of Clostridioides difficile spores in response to multiple environmental signals. PMID:31276487
Ambidextrous helical nanotubes from self-assembly of designed helical hairpin motifs. PMID:31262809
Burkholderia pseudomallei d-alanine-d-alanine ligase; detailed characterisation and assessment of a potential antibiotic drug target. PMID:31260169
Structural Basis of Tryptophan Reverse N-Prenylation Catalyzed by CymD. PMID:31251043
Structural Basis of Protein Kinase R Autophosphorylation. PMID:31246429
Insights into real-time chemical processes in a calcium sensor protein-directed dynamic library. PMID:31243268
Allosteric modulation of a human protein kinase with monobodies. PMID:31239342
Structural basis of Type IV CRISPR RNA biogenesis by a Cas6 endoribonuclease. PMID:31232162
Structural Basis of CD160:HVEM Recognition. PMID:31230945
Studies of the oligomerisation mechanism of a cystatin-based engineered protein scaffold. PMID:31227800
Structural basis for the homotypic fusion of chlamydial inclusions by the SNARE-like protein IncA. PMID:31227715
Cryo-EM structure of OSCA1.2 from Oryza sativa elucidates the mechanical basis of potential membrane hyperosmolality gating. PMID:31227607
Affinity Isolation and Mass Spectrometry Identification of Prostacyclin Synthase (PTGIS) Subinteractome. PMID:31226805
Analysis of the TP53 Deleterious Single Nucleotide Polymorphisms Impact on Estrogen Receptor Alpha-p53 Interaction: A Machine Learning Approach. PMID:31216622
Sera Antibody Repertoire Analyses Reveal Mechanisms of Broad and Pandemic Strain Neutralizing Responses after Human Norovirus Vaccination. PMID:31216462
Stochastic protein multimerization, activity, and fitness. PMID:31214661
Structural Characterization of Arabidopsis thaliana NAP1-Related Protein 2 (AtNRP2) and Comparison with its Homolog AtNRP1. PMID:31213016
The steroid side-chain-cleaving aldolase Ltp2-ChsH2DUF35 is a thiolase superfamily member with a radically repurposed active site. PMID:31209106
Pyrimidine biosynthesis in pathogens - Structures and analysis of dihydroorotases from Yersinia pestis and Vibrio cholerae. PMID:31207330
Conformational switches control early maturation of the eukaryotic small ribosomal subunit. PMID:31206356
Analysis of interleukin-20 receptor complexes in trabecular meshwork cells and effects of cytokine signaling in anterior segment perfusion culture. PMID:31205408
Changes in the allosteric site of human liver pyruvate kinase upon activator binding include the breakage of an intersubunit cation-π bond. PMID:31204694
A new crystal structure and small-angle X-ray scattering analysis of the homodimer of human SFPQ. PMID:31204691
Crystal structure of the 65-kilodalton amino-terminal fragment of DNA topoisomerase I from the gram-positive model organism Streptococcus mutans. PMID:31204053
Decrypting protein surfaces by combining evolution, geometry, and molecular docking. PMID:31199528
Kistamicin biosynthesis reveals the biosynthetic requirements for production of highly crosslinked glycopeptide antibiotics. PMID:31197182
The heme-sensitive regulator SbnI has a bifunctional role in staphyloferrin B production by Staphylococcus aureus. PMID:31197035
Conformational Plasticity in the HIV-1 Fusion Peptide Facilitates Recognition by Broadly Neutralizing Antibodies. PMID:31194940
Structural mechanism for NEK7-licensed activation of NLRP3 inflammasome. PMID:31189953
Structure and Properties of a Natural Competence-Associated Pilin Suggest a Unique Pilus Tip-Associated DNA Receptor. PMID:31186316
Features and structure of a cold active N-acetylneuraminate lyase. PMID:31185017
A novel druggable interprotomer pocket in the capsid of rhino- and enteroviruses. PMID:31185007
Characterization of the pleiotropic LysR-type transcription regulator LeuO of Escherichia coli. PMID:31184713
Structural and biochemical analysis of a phosin from Streptomyces chartreusis reveals a combined polyphosphate- and metal-binding fold. PMID:31183865
Crystal structures of Moorella thermoacetica cyanuric acid hydrolase reveal conformational flexibility and asymmetry important for catalysis. PMID:31181074
In silico analyses of molecular interactions between groundnut bud necrosis virus and its vector, Thrips palmi. PMID:31179363
A new crystal form of human acetylcholinesterase for exploratory room-temperature crystallography studies. PMID:31176713
Structural basis for human coronavirus attachment to sialic acid receptors. PMID:31160783
Crystal structure of a Y-box binding protein 1 (YB-1)-RNA complex reveals key features and residues interacting with RNA. PMID:31160337
Structural and biochemical characterization of Rv0187, an O-methyltransferase from Mycobacterium tuberculosis. PMID:31147608
Structure of the super-elongation complex subunit AFF4 C-terminal homology domain reveals requirements for AFF homo- and heterodimerization. PMID:31147444
PRODIGY-crystal: a web-tool for classification of biological interfaces in protein complexes. PMID:31141126
The major secreted protein of the whipworm parasite tethers to matrix and inhibits interleukin-13 function. PMID:31138806
Spermidine Synthase (SPDS) Undergoes Concerted Structural Rearrangements Upon Ligand Binding - A Case Study of the Two SPDS Isoforms From Arabidopsis thaliana. PMID:31134111
Structural basis for neutralization of Plasmodium vivax by naturally acquired human antibodies that target DBP. PMID:31133752
Molecular characterization of CHAD domains as inorganic polyphosphate-binding modules. PMID:31133615
Asymmetry in catalysis by Thermotoga maritima membrane-bound pyrophosphatase demonstrated by a nonphosphorus allosteric inhibitor. PMID:31131322
Broad and Potent Neutralizing Antibodies Recognize the Silent Face of the HIV Envelope. PMID:31126879
Tumor suppression of novel anti-PD-1 antibodies mediated through CD28 costimulatory pathway. PMID:31123083
Crystal structures of the c-di-AMP-synthesizing enzyme CdaA. PMID:31118276
Disrupted apolipoprotein L1-miR193a axis dedifferentiates podocytes through autophagy blockade in an APOL1 risk milieu. PMID:31116585
Structural and functional analyses of the N-terminal domain of the A subunit of a Bacillus megaterium spore germinant receptor. PMID:31113879
Structural insights into histone chaperone Chz1-mediated H2A.Z recognition and histone replacement. PMID:31107867
Structures of maintenance of carboxysome distribution Walker-box McdA and McdB adaptor homologs. PMID:31106331
Geometric description of self-interaction potential in symmetric protein complexes. PMID:31101822
Structural basis for the acetylation of histone H3K9 and H3K27 mediated by the histone chaperone Vps75 in Pneumocystis carinii. PMID:31098304
TCR-induced alteration of primary MHC peptide anchor residue. PMID:31091334
Design and Characterization of Protein E-PilA, a Candidate Fusion Antigen for Nontypeable Haemophilus influenzae Vaccine. PMID:31085711
Face-time with TAR: Portraits of an HIV-1 RNA with diverse modes of effector recognition relevant for drug discovery. PMID:31080171
Structural basis for catalysis and substrate specificity of a 3C-like cysteine protease from a mosquito mesonivirus. PMID:31078932
Identification of conformation-selective nanobodies against the membrane protein insertase BamA by an integrated structural biology approach. PMID:31073665
Structural analysis of a Vibrio phospholipase reveals an unusual Ser-His-chloride catalytic triad. PMID:31073025
DNA-guided DNA cleavage at moderate temperatures by Clostridium butyricum Argonaute. PMID:31069393
Crystal structure of the leucine-rich repeat ectodomain of the plant immune receptor kinase SOBIR1. PMID:31063151
Structural basis of substrate recognition by a novel thermostable (S)-enantioselective ω-transaminase from Thermomicrobium roseum. PMID:31061438
Structural basis for functional interactions in dimers of SLC26 transporters. PMID:31048734
Noncovalent structure of SENP1 in complex with SUMO2. PMID:31045562
Modeling of Protein⁻Protein Interactions in Cytokinin Signal Transduction. PMID:31035389
Adaptive Evolution within Gut Microbiomes of Healthy People. PMID:31028005
Structure of a Therapeutic Full-Length Anti-NPRA IgG4 Antibody: Dissecting Conformational Diversity. PMID:31023536
Multiple conformational states of the HPK1 kinase domain in complex with sunitinib reveal the structural changes accompanying HPK1 trans-regulation. PMID:31018963
Impact of charge state on 193 nm ultraviolet photodissociation of protein complexes. PMID:31016301
Engineering nanomolar peptide ligands that differentially modulate EphA2 receptor signaling. PMID:31015204
Characterization of the phosphotransacetylase-acetate kinase pathway for ATP production in Porphyromonas gingivalis. PMID:31007866
A systematic simulation-based meta-analytical framework for prediction of physiological biomarkers in alopecia. PMID:30993080
Evidence of Destabilization of the Human Thymidylate Synthase (hTS) Dimeric Structure Induced by the Interface Mutation Q62R. PMID:30987202
Structural Study of Agmatine Iminohydrolase From Medicago truncatula, the Second Enzyme of the Agmatine Route of Putrescine Biosynthesis in Plants. PMID:30984210
A global map of the protein shape universe. PMID:30978181
Structure of Sesquisabinene Synthase 1, a Terpenoid Cyclase That Generates a Strained [3.1.0] Bridged-Bicyclic Product. PMID:30977996
Structural insights into the modulatory role of the accessory protein WYL1 in the Type VI-D CRISPR-Cas system. PMID:30976796
Structural analyses of NudT16-ADP-ribose complexes direct rational design of mutants with improved processing of poly(ADP-ribosyl)ated proteins. PMID:30976021
A structural and functional analysis of the glycosyltransferase BshA from Staphylococcus aureus: Insights into the reaction mechanism and regulation of bacillithiol production. PMID:30968475
Principles and characteristics of biological assemblies in experimentally determined protein structures. PMID:30965224
Rad54 Phosphorylation Promotes Homologous Recombination by Balancing Rad54 Mobility and DNA Binding. PMID:30961891
The Chaperonin TRiC/CCT Associates with Prefoldin through a Conserved Electrostatic Interface Essential for Cellular Proteostasis. PMID:30955883
Supramolecular arrangement of the full-length Zika virus NS5. PMID:30951555
The putative polysaccharide deacetylase Ba0331: cloning, expression, crystallization and structure determination. PMID:30950833
Structure of a critical metabolic enzyme: S-adenosylmethionine synthetase from Cryptosporidium parvum. PMID:30950830
The structure of lipopolysaccharide transport protein B (LptB) from Burkholderia pseudomallei. PMID:30950822
Increased versatility despite reduced molecular complexity: evolution, structure and function of metazoan splicing factor PRPF39. PMID:30949712
Ca2+-dependent regulation of sodium channels NaV1.4 and NaV1.5 is controlled by the post-IQ motif. PMID:30944319
Relative interfacial cleavage energetics of protein complexes revealed by surface collisions. PMID:30944216
Molecular Basis of Broad Spectrum N-Glycan Specificity and Processing of Therapeutic IgG Monoclonal Antibodies by Endoglycosidase S2. PMID:30937380
Crystal Structure of VapBC-1 from Nontypeable Haemophilus influenzae and the Effect of PIN Domain Mutations on Survival during Infection. PMID:30936373
Binding of the regulatory domain of MutL to the sliding β-clamp is species specific. PMID:30916336
Structural investigation of Rett-inducing MeCP2 mutations. PMID:30906830
X-Ray Structure of Human Sulfide:Quinone Oxidoreductase: Insights into the Mechanism of Mitochondrial Hydrogen Sulfide Oxidation. PMID:30905673
MM-131, a bispecific anti-Met/EpCAM mAb, inhibits HGF-dependent and HGF-independent Met signaling through concurrent binding to EpCAM. PMID:30898885
Crystal structure and epitope analysis of house dust mite allergen Der f 21. PMID:30894561
Cryo-EM structures of Helicobacter pylori vacuolating cytotoxin A oligomeric assemblies at near-atomic resolution. PMID:30894496
Bisubstrate analogues as structural tools to investigate m6A methyltransferase active sites. PMID:30879411
Crystal structure of the TreS:Pep2 complex, initiating α-glucan synthesis in the GlgE pathway of mycobacteria. PMID:30877199
In situ and high-resolution cryo-EM structure of a bacterial type VI secretion system membrane complex. PMID:30877094
Exploring designability of electrostatic complementarity at an antigen-antibody interface directed by mutagenesis, biophysical analysis, and molecular dynamics simulations. PMID:30872635
Structure of mammalian plasma fetuin-B and its mechanism of selective metallopeptidase inhibition. PMID:30867929
A cytosine modification mechanism revealed by the structure of a ternary complex of deoxycytidylate hydroxymethylase from bacteriophage T4 with its cofactor and substrate. PMID:30867918
Drug Repositioning Inferred from E2F1-Coregulator Interactions Studies for the Prevention and Treatment of Metastatic Cancers. PMID:30867845
CryoEM structure of adenovirus type 3 fibre with desmoglein 2 shows an unusual mode of receptor engagement. PMID:30862836
An ensemble of lipoxygenase structures reveals novel conformations of the Fe coordination sphere. PMID:30861228
The complete structure of the human TFIIH core complex. PMID:30860024
The carbon monoxide dehydrogenase accessory protein CooJ is a histidine-rich multidomain dimer containing an unexpected Ni(II)-binding site. PMID:30858174
Directed Assembly of Homopentameric Cholera Toxin B-Subunit Proteins into Higher-Order Structures Using Coiled-Coil Appendages. PMID:30856321
Structures of Class Id Ribonucleotide Reductase Catalytic Subunits Reveal a Minimal Architecture for Deoxynucleotide Biosynthesis. PMID:30855138
Structural Basis for S100B Interaction with its Target Proteins. PMID:30854023
FIP200 Claw Domain Binding to p62 Promotes Autophagosome Formation at Ubiquitin Condensates. PMID:30853400
Cryo-EM fibril structures from systemic AA amyloidosis reveal the species complementarity of pathological amyloids. PMID:30846696
A small-molecule fusion inhibitor of influenza virus is orally active in mice. PMID:30846569
Testosterone meets albumin - the molecular mechanism of sex hormone transport by serum albumins. PMID:30842823
The structure of CgnJ, a domain of unknown function protein from the crocagin gene cluster. PMID:30839296
Disruption of APOL1-miR193a Axis Induces Disorganization of Podocyte Actin Cytoskeleton. PMID:30837512
Structural characterization of the Imm52 family protein TsiT in Pseudomonas aeruginosa. PMID:30834616
Structure of the zebrafish galectin-1-L2 and model of its interaction with the infectious hematopoietic necrosis virus (IHNV) envelope glycoprotein. PMID:30834446
The Plasticity of Molecular Interactions Governs Bacterial Microcompartment Shell Assembly. PMID:30833088
A Peptide-Induced Self-Cleavage Reaction Initiates the Activation of Tyrosinase. PMID:30825403
Formylglycine-generating enzyme binds substrate directly at a mononuclear Cu(I) center to initiate O2 activation. PMID:30824597
Oligomeric protein interference validates druggability of aspartate interconversion in Plasmodium falciparum. PMID:30821109
Molecular basis of cullin-3 (Cul3) ubiquitin ligase subversion by vaccinia virus protein A55. PMID:30819806
Structural Analysis of Recent Allergen-Antibody Complexes and Future Directions. PMID:30815753
Structural mechanism for versatile cargo recognition by the yeast class V myosin Myo2. PMID:30804213
Mutations in ILK, encoding integrin-linked kinase, are associated with arrhythmogenic cardiomyopathy. PMID:30802431
Structural insights into the inhibition properties of archaeon citrate synthase from Metallosphaera sedula. PMID:30794680
Novel Ca2+ -independent carbohydrate recognition of the C-type lectins, SPL-1 and SPL-2, from the bivalve Saxidomus purpuratus. PMID:30793424
Dimerization of a ubiquitin variant leads to high affinity interactions with a ubiquitin interacting motif. PMID:30793400
Enzymatic and Structural Characterization of the Naegleria fowleri Glucokinase. PMID:30783001
An efficient, step-economical strategy for the design of functional metalloproteins. PMID:30778140
Structural insights into chaperone addiction of toxin-antitoxin systems. PMID:30770830
Diversity within the adenovirus fiber knob hypervariable loops influences primary receptor interactions. PMID:30765704
Crystal structure of MICU2 and comparison with MICU1 reveal insights into the uniporter gating mechanism. PMID:30755530
Structural basis of ubiquitin recognition by the winged-helix domain of Cockayne syndrome group B protein. PMID:30753618
Reversible fold-switching controls the functional cycle of the antitermination factor RfaH. PMID:30742024
Activation of the Endonuclease that Defines mRNA 3' Ends Requires Incorporation into an 8-Subunit Core Cleavage and Polyadenylation Factor Complex. PMID:30737185
Thermostable Branched-Chain Amino Acid Transaminases From the Archaea Geoglobus acetivorans and Archaeoglobus fulgidus: Biochemical and Structural Characterization. PMID:30733943
Tailoring the properties of (catalytically)-active inclusion bodies. PMID:30732596
Metastable asymmetrical structure of a shaftless V1 motor. PMID:30729160
Breaking tolerance with engineered class I antigen-presenting molecules. PMID:30728302
R pyocin tail fiber structure reveals a receptor-binding domain with a lectin fold. PMID:30721244
Structure and function of the Ts2631 endolysin of Thermus scotoductus phage vB_Tsc2631 with unique N-terminal extension used for peptidoglycan binding. PMID:30718611
Molecular basis for AU-rich element recognition and dimerization by the HuR C-terminal RRM. PMID:30718402
The interplay of the metallosensor CueR with two distinct CopZ chaperones defines copper homeostasis in Pseudomonas aeruginosa. PMID:30718281
Structural basis of DSF recognition by its receptor RpfR and its regulatory interaction with the DSF synthase RpfF. PMID:30716063
Crystal structure of the programmed cell death 5 protein from Sulfolobus solfataricus. PMID:30713157
Unexpected Receptor Functional Mimicry Elucidates Activation of Coronavirus Fusion. PMID:30712865
PvdF of pyoverdin biosynthesis is a structurally unique N10-formyltetrahydrofolate-dependent formyltransferase. PMID:30689984
Molecular basis of synaptic specificity by immunoglobulin superfamily receptors in Drosophila. PMID:30688651
Surface-Induced Dissociation of Noncovalent Protein Complexes in an Extended Mass Range Orbitrap Mass Spectrometer. PMID:30688442
A 2.08 Å resolution structure of HLB5, a novel cellulase from the anaerobic gut bacterium Parabacteroides johnsonii DSM 18315. PMID:30687968
Immunoinformatic and systems biology approaches to predict and validate peptide vaccines against Epstein-Barr virus (EBV). PMID:30679646
Illuminating the catalytic core of ectoine synthase through structural and biochemical analysis. PMID:30674920
Near-atomic structure of a giant virus. PMID:30674888
Structure and flexibility of the extracellular region of the PirB receptor. PMID:30674550
Structural and Functional Studies of the RBPJ-SHARP Complex Reveal a Conserved Corepressor Binding Site. PMID:30673607
Structural Analysis of the Hanks-Type Protein Kinase YabT From Bacillus subtilis Provides New Insights in its DNA-Dependent Activation. PMID:30671027
Potent, multi-target serine protease inhibition achieved by a simplified β-sheet motif. PMID:30668585
Crystal structure of E. coli PRPP synthetase. PMID:30646888
Crystal structure of chloramphenicol-metabolizing enzyme EstDL136 from a metagenome. PMID:30645605
The crystal structure of the N-acetylglucosamine 2-epimerase from Nostoc sp. KVJ10 reveals the true dimer. PMID:30644848
Acetylation of CCAR2 Establishes a BET/BRD9 Acetyl Switch in Response to Combined Deacetylase and Bromodomain Inhibition. PMID:30643017
Structural basis of a potent human monoclonal antibody against Zika virus targeting a quaternary epitope. PMID:30642974
Structure, Mechanism, and Inhibition of Aspergillus fumigatus Thioredoxin Reductase. PMID:30642940
A New Class of Phosphoribosyltransferases Involved in Cobamide Biosynthesis Is Found in Methanogenic Archaea and Cyanobacteria. PMID:30640434
Mechanistic Insights into the cis- and trans-Acting DNase Activities of Cas12a. PMID:30639240
Cryo-Cooling Effect on DHFR Crystal Studied by Replica-Exchange Molecular Dynamics Simulations. PMID:30638963
Structure of the SLy1 SAM homodimer reveals a new interface for SAM domain self-association. PMID:30631134
Structural mechanism of transcription inhibition by lasso peptides microcin J25 and capistruin. PMID:30626643
Direct binding of Cdt2 to PCNA is important for targeting the CRL4Cdt2 E3 ligase activity to Cdt1. PMID:30623174
Crystal Structure of Histidine Triad Nucleotide-Binding Protein from the Pathogenic Fungus Candida albicans. PMID:30622225
Insights into Thiotemplated Pyrrole Biosynthesis Gained from the Crystal Structure of Flavin-Dependent Oxidase in Complex with Carrier Protein. PMID:30620182
Genetic and structural insights into broad neutralization of hepatitis C virus by human VH1-69 antibodies. PMID:30613781
Biosynthesis of mycobacterial methylmannose polysaccharides requires a unique 1-O-methyltransferase specific for 3-O-methylated mannosides. PMID:30606802
GABAA receptor signalling mechanisms revealed by structural pharmacology. PMID:30602790
Cryo-EM structure of the human α1β3γ2 GABAA receptor in a lipid bilayer. PMID:30602789
ParST is a widespread toxin-antitoxin module that targets nucleotide metabolism. PMID:30598453
Trypanosoma brucei RRP44 is involved in an early stage of large ribosomal subunit RNA maturation. PMID:30593255
The small RbcS-like domains of the β-carboxysome structural protein CcmM bind RubisCO at a site distinct from that binding the RbcS subunit. PMID:30591587
Structural Insights into the FtsQ/FtsB/FtsL Complex, a Key Component of the Divisome. PMID:30584256
Crystal structure of the DENR-MCT-1 complex revealed zinc-binding site essential for heterodimer formation. PMID:30584092
Structural and Biochemical Characterization of Aldehyde Dehydrogenase 12, the Last Enzyme of Proline Catabolism in Plants. PMID:30580036
The crystal structure of glucokinase from Leishmania braziliensis. PMID:30571993
Deciphering the ATP-binding mechanism(s) in NLRP-NACHT 3D models using structural bioinformatics approaches. PMID:30571723
Structure of the type VI secretion system TssK-TssF-TssG baseplate subcomplex revealed by cryo-electron microscopy. PMID:30568167
Solution Structure, Self-Assembly, and Membrane Interactions of the Matrix Protein from Newcastle Disease Virus at Neutral and Acidic pH. PMID:30567981
Structural basis for the specificity of renin-mediated angiotensinogen cleavage. PMID:30563843
Deciphering evolution of immune recognition in antibodies. PMID:30563492
Preacinetobactin not acinetobactin is essential for iron uptake by the BauA transporter of the pathogen Acinetobacter baumannii. PMID:30558715
Crystal structures of HpSoj-DNA complexes and the nucleoid-adaptor complex formation in chromosome segregation. PMID:30544248
Structure of native lens connexin 46/50 intercellular channels by cryo-EM. PMID:30542154
Structural organization of a major neuronal G protein regulator, the RGS7-Gβ5-R7BP complex. PMID:30540250
Molecular basis for the acid-initiated uncoating of human enterovirus D68. PMID:30530701
Structural and functional characterization of an intradiol ring-cleavage dioxygenase from the polyphagous spider mite herbivore Tetranychus urticae Koch. PMID:30529144
A Mechanically Weak Extracellular Membrane-Adjacent Domain Induces Dimerization of Protocadherin-15. PMID:30527337
Structural insight into substrate and product binding in an archaeal mevalonate kinase. PMID:30521590
Structural mechanism for HIV-1 TAR loop recognition by Tat and the super elongation complex. PMID:30514815
Structure-function analysis of Sedolisins: evolution of tripeptidyl peptidase and endopeptidase subfamilies in fungi. PMID:30514213
Structural studies of a glycoside hydrolase family 3 β-glucosidase from the model fungus Neurospora crassa. PMID:30511673
Biosynthesis of histone messenger RNA employs a specific 3' end endonuclease. PMID:30507380
Crystal structure of the complex between venom toxin and serum inhibitor from Viperidae snake. PMID:30504218
A Gcn5-Related N-Acetyltransferase (GNAT) Capable of Acetylating Polymyxin B and Colistin Antibiotics in Vitro. PMID:30499668
Distinguishing crystallographic from biological interfaces in protein complexes: role of intermolecular contacts and energetics for classification. PMID:30497368
Cryo-EM structures and dynamics of substrate-engaged human 26S proteasome. PMID:30479383
Individually double minimum-distance definition of protein-RNA binding residues and application to structure-based prediction. PMID:30478757
Non-crystallographic symmetry in proteins: Jahn-Teller-like and Butterfly-like effects? PMID:30470900
Neuron-Subtype-Specific Expression, Interaction Affinities, and Specificity Determinants of DIP/Dpr Cell Recognition Proteins. PMID:30467080
Structural snapshots of OxyR reveal the peroxidatic mechanism of H2O2 sensing. PMID:30463959
Structural identification of conserved RNA binding sites in herpesvirus ORF57 homologs: implications for PAN RNA recognition. PMID:30462297
The crystal structure of Staufen1 in complex with a physiological RNA sheds light on substrate selectivity. PMID:30456389
A PxL motif promotes timely cell cycle substrate dephosphorylation by the Cdc14 phosphatase. PMID:30455435
Changes of Cell Biochemical States Are Revealed in Protein Homomeric Complex Dynamics. PMID:30454649
Large-scale conformational changes and redistribution of surface negative charge upon sugar binding dictate the fidelity of phosphorylation in Vibrio cholerae fructokinase. PMID:30446722
Unique mechanism of target recognition by PfoI restriction endonuclease of the CCGG-family. PMID:30445642
Small-angle neutron scattering studies on the AMPA receptor GluA2 in the resting, AMPA-bound and GYKI-53655-bound states. PMID:30443361
Characterisation of a diazinon-metabolising glutathione S-transferase in the silkworm Bombyx mori by X-ray crystallography and genome editing analysis. PMID:30443011
HCV Broadly Neutralizing Antibodies Use a CDRH3 Disulfide Motif to Recognize an E2 Glycoprotein Site that Can Be Targeted for Vaccine Design. PMID:30439340
Structure and oligomerization of the periplasmic domain of GspL from the type II secretion system of Pseudomonas aeruginosa. PMID:30425318
Structural insights into the function of type VI secretion system TssA subunits. PMID:30420757
Tri-arginine exosite patch of caspase-6 recruits substrates for hydrolysis. PMID:30420425
Refining the macromolecular model - achieving the best agreement with the data from X-ray diffraction experiment. PMID:30416256
Surface-Induced Dissociation: An Effective Method for Characterization of Protein Quaternary Structure. PMID:30412666
Analysis of the Binding of Aripiprazole to Human Serum Albumin: The Importance of a Chloro-Group in the Chemical Structure. PMID:30411049
Structure of the 4-1BB/4-1BBL complex and distinct binding and functional properties of utomilumab and urelumab. PMID:30410017
The conserved mosaic prophage protein paratox inhibits the natural competence regulator ComR in Streptococcus. PMID:30409983
Carboxypeptidase in prolyl oligopeptidase family: Unique enzyme activation and substrate-screening mechanisms. PMID:30409909
The ribosomal maturation factor P from Mycobacterium smegmatis facilitates the ribosomal biogenesis by binding to the small ribosomal protein S12. PMID:30409901
A novel decarboxylating amidohydrolase involved in avoiding metabolic dead ends during cyanuric acid catabolism in Pseudomonas sp. strain ADP. PMID:30399173
A comparative structural analysis of the surface properties of asco-laccases. PMID:30395580
Heterohexamers Formed by CcmK3 and CcmK4 Increase the Complexity of Beta Carboxysome Shells. PMID:30389783
Crystal structures and kinetics of N-acetylneuraminate lyase from Fusobacterium nucleatum. PMID:30387778
New Thermophilic α/β Class Epoxide Hydrolases Found in Metagenomes From Hot Environments. PMID:30386778
Cryo-EM structure of the mechanically activated ion channel OSCA1.2. PMID:30382939
Structural basis for activation of fluorogenic dyes by an RNA aptamer lacking a G-quadruplex motif. PMID:30382099
Identification and characterization of a large family of superbinding bacterial SH2 domains. PMID:30382091
Novel regulatory mechanism of establishment genes of conjugative plasmids. PMID:30380104
Structural delineation of potent transmission-blocking epitope I on malaria antigen Pfs48/45. PMID:30367064
Structural and kinetic analyses of penicillin-binding protein 4 (PBP4)-mediated antibiotic resistance in Staphylococcus aureus. PMID:30366985
Co-Evolution of Intrinsically Disordered Proteins with Folded Partners Witnessed by Evolutionary Couplings. PMID:30366362
A single amino acid distorts the Fc γ receptor IIIb/CD16b structure upon binding immunoglobulin G1 and reduces affinity relative to CD16a. PMID:30361439
Spectral and structural analysis of large Stokes shift fluorescent protein dKeima570. PMID:30353468
Structure of the Macrobrachium rosenbergii nodavirus: A new genus within the Nodaviridae? PMID:30346944
CSGID Solves Structures and Identifies Phenotypes for Five Enzymes in Toxoplasma gondii. PMID:30345257
Transition-State Analogues of Campylobacter jejuni 5'-Methylthioadenosine Nucleosidase. PMID:30339406
Retraction: Crystal structure of a Baeyer-Villiger flavin-containing monooxygenase from Staphylococcus aureus MRSA strain MU50, William C. Hwang, Qingping Xu, Bainan Wu, Adam Godzik. PMID:30338968
Retraction: Site‐specific recombination of nitrogen‐fixation genes in cyanobacteria by XisF–XisH–XisI complex: Structures and models, William C. Hwang, James W. Golden, Jaime Pascual, Dong Xu, Anton Cheltsov, Adam Godzik. PMID:30338965
The molecular basis of protein toxin HicA-dependent binding of the protein antitoxin HicB to DNA. PMID:30337369
High-Resolution Structural Characterization of a New Adeno-associated Virus Serotype 5 Antibody Epitope toward Engineering Antibody-Resistant Recombinant Gene Delivery Vectors. PMID:30333169
Structural, functional and biological insights into the role of Mycobacterium tuberculosis VapBC11 toxin-antitoxin system: targeting a tRNase to tackle mycobacterial adaptation. PMID:30329074
Structural basis for receptor-regulated SMAD recognition by MAN1. PMID:30321401
Structural basis for isoform-specific kinesin-1 recognition of Y-acidic cargo adaptors. PMID:30320553
Structure and Catalytic Mechanism of a Bacterial Friedel-Crafts Acylase. PMID:30318713
A Viral Protein Restricts Drosophila RNAi Immunity by Regulating Argonaute Activity and Stability. PMID:30308158
Structural Analysis of an Epitope Candidate of Triosephosphate Isomerase in Opisthorchis viverrini. PMID:30305716
Molecular mechanism of activation of the immunoregulatory amidase NAAA. PMID:30301806
Structural insights into the electron/proton transfer pathways in the quinol:fumarate reductase from Desulfovibrio gigas. PMID:30297797
Heterozygous loss-of-function variants of MEIS2 cause a triad of palatal defects, congenital heart defects, and intellectual disability. PMID:30291340
Pathological macromolecular crystallographic data affected by twinning, partial-disorder and exhibiting multiple lattices for testing of data processing and refinement tools. PMID:30291262
A multisubstrate reductase from Plantago major: structure-function in the short chain reductase superfamily. PMID:30287897
Cellular production of a counterfeit viral protein confers immunity to infection by a related virus. PMID:30280045
X-ray structure of Arthrobacter globiformis M30 ketose 3-epimerase for the production of D-allulose from D-fructose. PMID:30279320
Comparative structure analysis of the ETSi domain of ERG3 and its complex with the E74 promoter DNA sequence. PMID:30279318
Structure of glyoxysomal malate dehydrogenase (MDH3) from Saccharomyces cerevisiae. PMID:30279312
Structure and N-acetylglucosamine binding of the distal domain of mouse adenovirus 2 fibre. PMID:30277856
Structure-Based Engineering of Phanerochaete chrysosporium Alcohol Oxidase for Enhanced Oxidative Power toward Glycerol. PMID:30272958
Structural rearrangements in the C-terminal domain homolog of Orange Carotenoid Protein are crucial for carotenoid transfer. PMID:30272005
Bent conformation of a backbone pilin N-terminal domain supports a three-stage pilus assembly mechanism. PMID:30271975
Structural and functional studies of the metalloregulator Fur identify a promoter-binding mechanism and its role in Francisella tularensis virulence. PMID:30271974
Tannerella forsythia Tfo belongs to Porphyromonas gingivalis HmuY-like family of proteins but differs in heme-binding properties. PMID:30266745
Structural insights into modulation and selectivity of transsynaptic neurexin-LRRTM interaction. PMID:30262834
Structural and biochemical characterization of the Cutibacterium acnes exo-β-1,4-mannosidase that targets the N-glycan core of host glycoproteins. PMID:30261037
A bidentate Polycomb Repressive-Deubiquitinase complex is required for efficient activity on nucleosomes. PMID:30258054
Structural basis for broad neutralization of ebolaviruses by an antibody targeting the glycoprotein fusion loop. PMID:30258051
Lysine as a heme iron ligand: A property common to three truncated hemoglobins from Chlamydomonas reinhardtii. PMID:30251657
Structural and functional characterisation of the entry point to pyocyanin biosynthesis in Pseudomonas aeruginosa defines a new 3-deoxy-d-arabino-heptulosonate 7-phosphate synthase subclass. PMID:30242059
A structural investigation of NRZ mediated apoptosis regulation in zebrafish. PMID:30237469
DARPins recognizing mTFP1 as novel reagents for in vitro and in vivo protein manipulations. PMID:30237292
Identification, functional characterization, and crystal structure determination of bacterial levoglucosan dehydrogenase. PMID:30224354
Structural determinants of Rab11 activation by the guanine nucleotide exchange factor SH3BP5. PMID:30217979
Crystal structure of TcpK in complex with oriT DNA of the antibiotic resistance plasmid pCW3. PMID:30213934
Engagement Rules That Underpin DBL-DARC Interactions for Ingress of Plasmodium knowlesi and Plasmodium vivax Into Human Erythrocytes. PMID:30211170
Crystal structure of the modification-dependent SRA-HNH endonuclease TagI. PMID:30202937
A novel chlorination-induced ribonuclease YabJ from Staphylococcus aureus. PMID:30201692
MBP-binding DARPins facilitate the crystallization of an MBP fusion protein. PMID:30198887
Structure of the Fc fragment of the NIST reference antibody RM8671. PMID:30198883
Oxidative cyclization of N-methyl-dopa by a fungal flavoenzyme of the amine oxidase family. PMID:30194285
Structural basis for murine norovirus engagement of bile acids and the CD300lf receptor. PMID:30194229
Structural Plasticity of Neurexin 1α: Implications for its Role as Synaptic Organizer. PMID:30193986
The quaternary structure of Thermus thermophilus aldehyde dehydrogenase is stabilized by an evolutionary distinct C-terminal arm extension. PMID:30190503
GEF mechanism revealed by the structure of SmgGDS-558 and farnesylated RhoA complex and its implication for a chaperone mechanism. PMID:30190425
NAD+ promotes assembly of the active tetramer of aldehyde dehydrogenase 7A1. PMID:30184263
Structural features of a bacterial cyclic α-maltosyl-(1→6)-maltose (CMM) hydrolase critical for CMM recognition and hydrolysis. PMID:30181215
The N-Terminal GTPase Domain of p190RhoGAP Proteins Is a PseudoGTPase. PMID:30174148
Structural basis of cell wall peptidoglycan amidation by the GatD/MurT complex of Staphylococcus aureus. PMID:30154570
Structure of a patient-derived antibody in complex with allergen reveals simultaneous conventional and superantigen-like recognition. PMID:30150373
Crystal Structure of the Human tRNA Guanine Transglycosylase Catalytic Subunit QTRT1. PMID:30149595
Structure of a Novel Dimeric SET Domain Methyltransferase that Regulates Cell Motility. PMID:30148980
A speculation on the tandem fasciclin 1 repeat of FLA4 proteins in angiosperms. PMID:30148420
Two Patched molecules engage distinct sites on Hedgehog yielding a signaling-competent complex. PMID:30139912
Architecture of the native major royal jelly protein 1 oligomer. PMID:30135511
Bonsai Gelsolin Survives Heat Induced Denaturation by Forming β-Amyloids which Leach Out Functional Monomer. PMID:30135452
HIF-2α-pVHL complex reveals broad genotype-phenotype correlations in HIF-2α-driven disease. PMID:30135421
The structure of the ubiquitin-like modifier FAT10 reveals an alternative targeting mechanism for proteasomal degradation. PMID:30127417
EPO does not promote interaction between the erythropoietin and beta-common receptors. PMID:30127368
Insights into degradation mechanism of N-end rule substrates by p62/SQSTM1 autophagy adapter. PMID:30120248
Supramolecular assembly of KAT2A with succinyl-CoA for histone succinylation. PMID:30109122
Activity and structure of EcoKMcrA. PMID:30107581
Structures of Hepatitis B Virus Core- and e-Antigen Immune Complexes Suggest Multi-point Inhibition. PMID:30100358
Structural Basis for MARK1 Kinase Autoinhibition by Its KA1 Domain. PMID:30099988
Compatibility of RUNX1/ETO fusion protein modules driving CD34+ human progenitor cell expansion. PMID:30093631
4-Hydroxy-tetrahydrodipicolinate reductase from Neisseria gonorrhoeae - structure and interactions with coenzymes and substrate analog. PMID:30093108
Pathogen-derived HLA-E bound epitopes reveal broad primary anchor pocket tolerability and conformationally malleable peptide binding. PMID:30087334
Mechanism by which water and protein electrostatic interactions control proton transfer at the active site of channelrhodopsin. PMID:30086158
Structure of the GH9 glucosidase/glucosaminidase from Vibrio cholerae. PMID:30084401
Crystal structure of highly glycosylated human leukocyte elastase in complex with an S2' site binding inhibitor. PMID:30084397
Biochemical and structural features of diverse bacterial glucuronoyl esterases facilitating recalcitrant biomass conversion. PMID:30083226
Structural analyses reveal the mechanism of inhibition of influenza virus NS1 by two antiviral compounds. PMID:30076219
Cryo-EM of the dynamin polymer assembled on lipid membrane. PMID:30069048
Structural basis for selective inhibition of immunoglobulin E-receptor interactions by an anti-IgE antibody. PMID:30069035
Identification, Characterization, and X-ray Crystallographic Analysis of a Novel Type of Lectin AJLec from the Sea Anemone Anthopleura japonica. PMID:30068923
Structural characterization of geranylgeranyl pyrophosphate synthase GACE1337 from the hyperthermophilic archaeon Geoglobus acetivorans. PMID:30062607
TraN: A novel repressor of an Enterococcus conjugative type IV secretion system. PMID:30060171
Structural and Functional Analysis of E. coli Cyclopropane Fatty Acid Synthase. PMID:30057024
Structural and Biochemical Characterization of AaL, a Quorum Quenching Lactonase with Unusual Kinetic Properties. PMID:30050039
A model for hydrophobic protrusions on peripheral membrane proteins. PMID:30048443
Structure and specificity of several triclocarban-binding single domain camelid antibody fragments. PMID:30033524
A Structure-Based Strategy for Engineering Selective Ubiquitin Variant Inhibitors of Skp1-Cul1-F-Box Ubiquitin Ligases. PMID:30033217
Gluconeogenic precursor availability regulates flux through the glyoxylate shunt in Pseudomonas aeruginosa. PMID:30030382
Pseudomonas aeruginosa pyoverdine maturation enzyme PvdP has a noncanonical domain architecture and affords insight into a new subclass of tyrosinases. PMID:30030378
Characterization of the binding mode of JNK-interacting protein 1 (JIP1) to kinesin-light chain 1 (KLC1). PMID:30026235
Investigation of Core Structure and Stability of Human Pyruvate Dehydrogenase Complex: A Coarse-Grained Approach. PMID:30023628
Crystal structure and substrate binding mode of ectonucleotide phosphodiesterase/pyrophosphatase-3 (NPP3). PMID:30022031
Structural and Functional Characterization of the BcsG Subunit of the Cellulose Synthase in Salmonella typhimurium. PMID:30017920
A non-canonical GTPase interaction enables ORP1L-Rab7-RILP complex formation and late endosome positioning. PMID:30012887
MouR controls the expression of the Listeria monocytogenes Agr system and mediates virulence. PMID:30011022
Product-oriented chemical surface modification of a levansucrase (SacB) via an ene-type reaction. PMID:30009003
Identification of a novel tRNA wobble uridine modifying activity in the biosynthesis of 5-methoxyuridine. PMID:29982645
Structures of DNA-bound human ligase IV catalytic core reveal insights into substrate binding and catalysis. PMID:29980672
Crystal Structure of the Dimerized N Terminus of Porcine Circovirus Type 2 Replicase Protein Reveals a Novel Antiviral Interface. PMID:29976661
Mechanism for remodelling of the cell cycle checkpoint protein MAD2 by the ATPase TRIP13. PMID:29973720
Crystal structures and kinetic analyses of N-acetylmannosamine-6-phosphate 2-epimerases from Fusobacterium nucleatum and Vibrio cholerae. PMID:29969107
Crystallization and X-ray analysis of all of the players in the autoregulation of the ataRT toxin-antitoxin system. PMID:29969102
Crystal structures of two tandem malectin-like receptor kinases involved in plant reproduction. PMID:29968676
Structural and functional analysis of cystatin E reveals enzymologically relevant dimer and amyloid fibril states. PMID:29967063
Structure of a human synaptic GABAA receptor. PMID:29950725
A cylindrical assembly model and dynamics of the Ebola virus VP40 structural matrix. PMID:29950600
The crystallization additive hexatungstotellurate promotes the crystallization of the HSP70 nucleotide binding domain into two different crystal forms. PMID:29949628
A human anti-IL-2 antibody that potentiates regulatory T cells by a structure-based mechanism. PMID:29942088
Capsid protein structure, self-assembly, and processing reveal morphogenesis of the marine virophage mavirus. PMID:29941605
Trichomonas vaginalis metalloproteinase TvMP50 is a monomeric Aminopeptidase P-like enzyme. PMID:29936696
Integrating co-evolutionary signals and other properties of residue pairs to distinguish biological interfaces from crystal contacts. PMID:29931702
Structural Basis for the Broad, Antibody-Mediated Neutralization of H5N1 Influenza Virus. PMID:29925655
Functional plasticity of antibacterial EndoU toxins. PMID:29923643
Differences in substrate specificity of V. cholerae FabH enzymes suggest new approaches for the development of novel antibiotics and biofuels. PMID:29917313
Cryo-EM structures of complex I from mouse heart mitochondria in two biochemically defined states. PMID:29915388
Structural and functional insights into the unique CBS-CP12 fusion protein family in cyanobacteria. PMID:29915055
Crystal structures of a [NiFe] hydrogenase large subunit HyhL in an immature state in complex with a Ni chaperone HypA. PMID:29915046
Reversing allosteric communication: From detecting allosteric sites to inducing and tuning targeted allosteric response. PMID:29912863
Broadly Reactive Human Monoclonal Antibodies Elicited following Pandemic H1N1 Influenza Virus Exposure Protect Mice against Highly Pathogenic H5N1 Challenge. PMID:29899095
The crystal structure of monoacylglycerol lipase from M. tuberculosis reveals the basis for specific inhibition. PMID:29895832
A Novel ShK-Like Toxic Peptide from the Transcriptome of the Cnidarian Palythoa caribaeorum Displays Neuroprotection and Cardioprotection in Zebrafish. PMID:29895785
Plasticity in binding confers selectivity in ligand-induced protein degradation. PMID:29892083
Structure of an Acinetobacter Broad-Range Prophage Endolysin Reveals a C-Terminal α-Helix with the Proposed Role in Activity against Live Bacterial Cells. PMID:29882827
Structural insight into the human mitochondrial tRNA purine N1-methyltransferase and ribonuclease P complexes. PMID:29880640
Functional insights into the Streptococcus pneumoniae HicBA toxin-antitoxin system based on a structural study. PMID:29878152
Asymmetric activation mechanism of a homodimeric red light-regulated photoreceptor. PMID:29869984
Natural separation of the acyl-CoA ligase reaction results in a non-adenylating enzyme. PMID:29867143
Noncatalytic Antioxidant Role for Helicobacter pylori Urease. PMID:29866802
Investigation of protein quaternary structure via stoichiometry and symmetry information. PMID:29864163
Combination of aptamer and drug for reversible anticoagulation in cardiopulmonary bypass. PMID:29863725
TOWARD BAYESIAN INFERENCE OF THE SPATIAL DISTRIBUTION OF PROTEINS FROM THREE-CUBE FÖRSTER RESONANCE ENERGY TRANSFER DATA. PMID:29861820
Immunogenicity Testing of Lipidoids In Vitro and In Silico: Modulating Lipidoid-Mediated TLR4 Activation by Nanoparticle Design. PMID:29858051
Structural Characterization of the Hydratase-Aldolases, NahE and PhdJ: Implications for the Specificity, Catalysis, and N-Acetylneuraminate Lyase Subgroup of the Aldolase Superfamily. PMID:29856600
Structural Plasticity in the C-Terminal Region of Macrophage Migration Inhibitory Factor-2 Is Associated with an Induced Fit Mechanism for a Selective Inhibitor. PMID:29847104
The archaeal ATPase PINA interacts with the helicase Hjm via its carboxyl terminal KH domain remodeling and processing replication fork and Holliday junction. PMID:29846688
Structural basis for recognition of 53BP1 tandem Tudor domain by TIRR. PMID:29844495
Potent and selective antitumor activity of a T cell-engaging bispecific antibody targeting a membrane-proximal epitope of ROR1. PMID:29844189
Molecular basis for the loss-of-function effects of the Alzheimer's disease-associated R47H variant of the immune receptor TREM2. PMID:29794134
Structure-based analysis of CysZ-mediated cellular uptake of sulfate. PMID:29792261
Functional and structural characterization of zebrafish ASC. PMID:29791979
Targeting G protein-coupled receptor signaling at the G protein level with a selective nanobody inhibitor. PMID:29777099
Comparison of Alicyclobacillus acidocaldarius o-Succinylbenzoate Synthase to Its Promiscuous N-Succinylamino Acid Racemase/ o-Succinylbenzoate Synthase Relatives. PMID:29767960
Structural basis for the recognition of complex-type N-glycans by Endoglycosidase S. PMID:29760474
Structure of Human NatA and Its Regulation by the Huntingtin Interacting Protein HYPK. PMID:29754825
Identification and structural characterization of a histidinol phosphate phosphatase from Mycobacterium tuberculosis. PMID:29752410
The protein kinase CK2 catalytic domain from Plasmodium falciparum: crystal structure, tyrosine kinase activity and inhibition. PMID:29743645
The universally-conserved transcription factor RfaH is recruited to a hairpin structure of the non-template DNA strand. PMID:29741479
Molecular mechanism of influenza A NS1-mediated TRIM25 recognition and inhibition. PMID:29739942
Structural and kinetic insights into stimulation of RppH-dependent RNA degradation by the metabolic enzyme DapF. PMID:29733359
Structural and functional determination of homologs of the Mycobacterium tuberculosis N-acetylglucosamine-6-phosphate deacetylase (NagA). PMID:29728457
A bipartite periplasmic receptor-diguanylate cyclase pair (XAC2383-XAC2382) in the bacterium Xanthomonas citri. PMID:29728456
Applying graph theory to protein structures: an Atlas of coiled coils. PMID:29722888
Structural principles of distinct assemblies of the human α4β2 nicotinic receptor. PMID:29720657
Crystal structure of the human 4-1BB/4-1BBL complex. PMID:29720399
Structure of frequency-interacting RNA helicase from Neurospora crassa reveals high flexibility in a domain critical for circadian rhythm and RNA surveillance. PMID:29718972
Structure of the tandem PX-PH domains of Bem3 from Saccharomyces cerevisiae. PMID:29718000
A Single Mutation Traps a Half-Sites Reactive Enzyme in Midstream, Explaining Asymmetry in Hydride Transfer. PMID:29717875
A new crystal form of Aspergillus oryzae catechol oxidase and evaluation of copper site structures in coupled binuclear copper enzymes. PMID:29715329
Computational identification, characterization and validation of potential antigenic peptide vaccines from hrHPVs E6 proteins using immunoinformatics and computational systems biology approaches. PMID:29715318
An endogenous dAMP ligand in Bacillus subtilis class Ib RNR promotes assembly of a noncanonical dimer for regulation by dATP. PMID:29712847
Chlamydial virulence factor TarP mimics talin to disrupt the talin-vinculin complex. PMID:29710402
Automated evaluation of quaternary structures from protein crystals. PMID:29708963
Ca2+-Triggered Synaptic Vesicle Fusion Initiated by Release of Inhibition. PMID:29706534
The Structure of an Infectious Human Polyomavirus and Its Interactions with Cellular Receptors. PMID:29706532
Assembly of human C-terminal binding protein (CtBP) into tetramers. PMID:29700119
Structural basis of product inhibition by arabinose and xylose of the thermostable GH43 β-1,4-xylosidase from Geobacillus thermoleovorans IT-08. PMID:29698436
Oligomeric interfaces as a tool in drug discovery: Specific interference with activity of malate dehydrogenase of Plasmodium falciparum in vitro. PMID:29694407
Worldwide Protein Data Bank biocuration supporting open access to high-quality 3D structural biology data. PMID:29688351
Structural and kinetic basis for the selectivity of aducanumab for aggregated forms of amyloid-β. PMID:29686315
Cryo-EM structure of infectious bronchitis coronavirus spike protein reveals structural and functional evolution of coronavirus spike proteins. PMID:29684066
Physiological temperatures reduce dimerization of dengue and Zika virus recombinant envelope proteins. PMID:29678884
Mechanistic and Structural Insights Into the Unique TetR-Dependent Regulation of a Drug Efflux Pump in Mycobacterium abscessus. PMID:29675007
Evolutionary plasticity of the NHL domain underlies distinct solutions to RNA recognition. PMID:29674686
An Antibody Targeting the Fusion Machinery Neutralizes Dual-Tropic Infection and Defines a Site of Vulnerability on Epstein-Barr Virus. PMID:29669253
Type II Secretion-Dependent Aminopeptidase LapA and Acyltransferase PlaC Are Redundant for Nutrient Acquisition during Legionella pneumophila Intracellular Infection of Amoebas. PMID:29666285
Hexameric and pentameric complexes of the ExbBD energizer in the Ton system. PMID:29661272
Insights into the pathogenesis of dominant retinitis pigmentosa associated with a D477G mutation in RPE65. PMID:29659842
Electrochemically-Driven Insertion of Biological Nanodiscs into Solid State Membrane Pores as a Basis for "Pore-In-Pore" Membranes. PMID:29652841
Structures of the Mycobacterium tuberculosis GlpX protein (class II fructose-1,6-bisphosphatase): implications for the active oligomeric state, catalytic mechanism and citrate inhibition. PMID:29652259
Crystal Structure of Botulinum Neurotoxin A2 in Complex with the Human Protein Receptor SV2C Reveals Plasticity in Receptor Binding. PMID:29649119
Quantitative characterization of all single amino acid variants of a viral capsid-based drug delivery vehicle. PMID:29643335
Crystal structure and mechanism of human carboxypeptidase O: Insights into its specific activity for acidic residues. PMID:29636417
The crystal structure of the drug target Mycobacterium tuberculosis methionyl-tRNA synthetase in complex with a catalytic intermediate. PMID:29633973
Crystal structure of RecR, a member of the RecFOR DNA-repair pathway, from Pseudomonas aeruginosa PAO1. PMID:29633970
The single berberine bridge enzyme homolog of Physcomitrella patens is a cellobiose oxidase. PMID:29633551
Substrate Recognition by a Colistin Resistance Enzyme from Moraxella catarrhalis. PMID:29631403
Structural Basis for Recognition of L-lysine, L-ornithine, and L-2,4-diamino Butyric Acid by Lysine Cyclodeaminase. PMID:29629557
Cryptic glucocorticoid receptor-binding sites pervade genomic NF-κB response elements. PMID:29626214
Staphylopine, pseudopaline, and yersinopine dehydrogenases: A structural and kinetic analysis of a new functional class of opine dehydrogenase. PMID:29618515
Structural and functional delineation of aerobactin biosynthesis in hypervirulent Klebsiella pneumoniae. PMID:29618511
Proline hydroxylation in collagen supports integrin binding by two distinct mechanisms. PMID:29615493
A small-molecule fragment that emulates binding of receptor and broadly neutralizing antibodies to influenza A hemagglutinin. PMID:29610325
Atomic Structure of the E2 Inner Core of Human Pyruvate Dehydrogenase Complex. PMID:29608861
A new HIV-1 Rev structure optimizes interaction with target RNA (RRE) for nuclear export. PMID:29605570
AAV6 K531 serves a dual function in selective receptor and antibody ADK6 recognition. PMID:29604478
Ensemble cryoEM elucidates the mechanism of insulin capture and degradation by human insulin degrading enzyme. PMID:29596046
First insights of peptidoglycan amidation in Gram-positive bacteria - the high-resolution crystal structure of Staphylococcus aureus glutamine amidotransferase GatD. PMID:29593310
Structural characterization of a highly-potent V3-glycan broadly neutralizing antibody bound to natively-glycosylated HIV-1 envelope. PMID:29593217
Structural modelling of the DNAJB6 oligomeric chaperone shows a peptide-binding cleft lined with conserved S/T-residues at the dimer interface. PMID:29581438
Complex Interplay between Epitope Specificity and Isotype Dictates the Biological Activity of Anti-human CD40 Antibodies. PMID:29576376
Structural basis for tumor necrosis factor blockade with the therapeutic antibody golimumab. PMID:29575262
Systematic characterization of pan-cancer mutation clusters. PMID:29572294
Structural and functional analysis of the DOT1L-AF10 complex reveals mechanistic insights into MLL-AF10-associated leukemogenesis. PMID:29563185
Crystal structure of an intramembranal phosphatase central to bacterial cell-wall peptidoglycan biosynthesis and lipid recycling. PMID:29559664
Structure of the activated Edc1-Dcp1-Dcp2-Edc3 mRNA decapping complex with substrate analog poised for catalysis. PMID:29559651
The structure of hydrogenase-2 from Escherichia coli: implications for H2-driven proton pumping. PMID:29555844
Transposase-DNA Complex Structures Reveal Mechanisms for Conjugative Transposition of Antibiotic Resistance. PMID:29551265
A Neutralizing Antibody Recognizing Primarily N-Linked Glycan Targets the Silent Face of the HIV Envelope. PMID:29548671
Structural and biochemical characterization of Siw14: A protein-tyrosine phosphatase fold that metabolizes inositol pyrophosphates. PMID:29540476
The invasin D protein from Yersinia pseudotuberculosis selectively binds the Fab region of host antibodies and affects colonization of the intestine. PMID:29535184
Distributed computing for macromolecular crystallography. PMID:29533240
Ensembles generated from crystal structures of single distant homologues solve challenging molecular-replacement cases in AMPLE. PMID:29533226
Recent developments in MrBUMP: better search-model preparation, graphical interaction with search models, and solution improvement and assessment. PMID:29533225
Structural basis of the Cope rearrangement and cyclization in hapalindole biogenesis. PMID:29531360
Archaeal acetoacetyl-CoA thiolase/HMG-CoA synthase complex channels the intermediate via a fused CoA-binding site. PMID:29531083
Crystal structure of a SFPQ/PSPC1 heterodimer provides insights into preferential heterodimerization of human DBHS family proteins. PMID:29530979
The 3.5-Å CryoEM Structure of Nanodisc-Reconstituted Yeast Vacuolar ATPase Vo Proton Channel. PMID:29526695
Structural and Functional Insights into Bacillus subtilis Sigma Factor Inhibitor, CsfB. PMID:29526435
An unexpected vestigial protein complex reveals the evolutionary origins of an s-triazine catabolic enzyme. PMID:29523689
Salvador has an extended SARAH domain that mediates binding to Hippo kinase. PMID:29519817
Structural basis for the regulatory interaction of the methylglyoxal synthase MgsA with the carbon flux regulator Crh in Bacillus subtilis. PMID:29514981
Structural basis for recognition of the central conserved region of RSV G by neutralizing human antibodies. PMID:29509814
Snapshots of C-S Cleavage in Egt2 Reveals Substrate Specificity and Reaction Mechanism. PMID:29503207
Assessing the Heterogeneity of the Fc-Glycan of a Therapeutic Antibody Using an engineered FcγReceptor IIIa-Immobilized Column. PMID:29500371
Crystal structure of an inferred ancestral bacterial pyruvate decarboxylase. PMID:29497023
Crystal structure of the MSMEG_4306 gene product from Mycobacterium smegmatis. PMID:29497021
The first crystal structure of manganese superoxide dismutase from the genus Staphylococcus. PMID:29497016
A potent complement factor C3-specific nanobody inhibiting multiple functions in the alternative pathway of human and murine complement. PMID:29497000
Uncovering the mechanistic basis for specific recognition of monomethylated H3K4 by the CW domain of Arabidopsis histone methyltransferase SDG8. PMID:29496997
Crystal structure and insights into the oligomeric state of UDP-glucose pyrophosphorylase from sugarcane. PMID:29494650
Grouper iridovirus GIV66 is a Bcl-2 protein that inhibits apoptosis by exclusively sequestering Bim. PMID:29483196
The H-subunit of the restriction endonuclease CglI contains a prototype DEAD-Z1 helicase-like motor. PMID:29471489
Escape of Hepatitis C Virus from Epitope I Neutralization Increases Sensitivity of Other Neutralization Epitopes. PMID:29467319
Structural and Mechanistic Analysis of the Choline Sulfatase from Sinorhizobium melliloti: A Class I Sulfatase Specific for an Alkyl Sulfate Ester. PMID:29458126
Biochemical Characterization of Two Clinically-Relevant Human Fumarase Variants Defective for Oligomerization. PMID:29456767
Insights into the inhibitory mechanisms of NADH on the αγ heterodimer of human NAD-dependent isocitrate dehydrogenase. PMID:29453450
Structural Characterization and Directed Evolution of a Novel Acetyl Xylan Esterase Reveals Thermostability Determinants of the Carbohydrate Esterase 7 Family. PMID:29453256
Cryo-EM structure of the bacterial actin AlfA reveals unique assembly and ATP-binding interactions and the absence of a conserved subdomain. PMID:29440491
Cryo-EM reconstruction of AlfA from Bacillus subtilis reveals the structure of a simplified actin-like filament at 3.4-Å resolution. PMID:29440489
Virulence of the Melioidosis Pathogen Burkholderia pseudomallei Requires the Oxidoreductase Membrane Protein DsbB. PMID:29440370
The Extracellular Domain of Pollen Receptor Kinase 3 is structurally similar to the SERK family of co-receptors. PMID:29434276
Structural basis of mammalian glycan targeting by Vibrio cholerae cytolysin and biofilm proteins. PMID:29432487
Divergent and parallel routes of biochemical adaptation in high-altitude passerine birds from the Qinghai-Tibet Plateau. PMID:29432191
Schistosoma mansoni SmKI-1 serine protease inhibitor binds to elastase and impairs neutrophil function and inflammation. PMID:29425229
Structure and function of the bacillithiol-S-transferase BstA from Staphylococcus aureus. PMID:29417696
Identification of a staphylococcal complement inhibitor with broad host specificity in equid Staphylococcus aureus strains. PMID:29414776
Crystal structure reveals vaccine elicited bactericidal human antibody targeting a conserved epitope on meningococcal fHbp. PMID:29410413
Structural characterization of Porphyromonas gingivalis enoyl-ACP reductase II (FabK). PMID:29400320
Molecular Interactions between a Fluoride Ion Channel and Synthetic Protein Blockers. PMID:29393634
A presumed homologue of the regulatory subunits of eIF2B functions as ribose-1,5-bisphosphate isomerase in Pyrococcus horikoshii OT3. PMID:29382938
Structures and mechanism of dipeptidyl peptidases 8 and 9, important players in cellular homeostasis and cancer. PMID:29382749
The Negative Effects of KPN00353 on Glycerol Kinase and Microaerobic 1,3-Propanediol Production in Klebsiella pneumoniae. PMID:29375490
Effects of Cross-Presentation, Antigen Processing, and Peptide Binding in HIV Evasion of T Cell Immunity. PMID:29374075
Structural characterization of a novel monotreme-specific protein with antimicrobial activity from the milk of the platypus. PMID:29372906
Structure of aspartate β-semialdehyde dehydrogenase from Francisella tularensis. PMID:29372903
Retinoic acid prevents immunogenicity of milk lipocalin Bos d 5 through binding to its immunodominant T-cell epitope. PMID:29371615
Crystal structure of thermospermine synthase from Medicago truncatula and substrate discriminatory features of plant aminopropyltransferases. PMID:29367265
Crystal structure of the NADP+ and tartrate-bound complex of L-serine 3-dehydrogenase from the hyperthermophilic archaeon Pyrobaculum calidifontis. PMID:29353380
Determination of protein oligomeric structure from small-angle X-ray scattering. PMID:29352739
Structural Study of the C-Terminal Domain of Nonstructural Protein 1 from Japanese Encephalitis Virus. PMID:29343583
Structures of β-klotho reveal a 'zip code'-like mechanism for endocrine FGF signalling. PMID:29342135
The crystal structure of D-xylonate dehydratase reveals functional features of enzymes from the Ilv/ED dehydratase family. PMID:29339766
Structural Basis for Activity and Specificity of an Anticoagulant Anti-FXIa Monoclonal Antibody and a Reversal Agent. PMID:29336885
A Novel Ultra-Stable, Monomeric Green Fluorescent Protein For Direct Volumetric Imaging of Whole Organs Using CLARITY. PMID:29330459
Docking, thermodynamics and molecular dynamics (MD) studies of a non-canonical protease inhibitor, MP-4, from Mucuna pruriens. PMID:29330385
Modeling the assembly order of multimeric heteroprotein complexes. PMID:29329283
The mechanism of glycosphingolipid degradation revealed by a GALC-SapA complex structure. PMID:29323104
Engineered synthetic antibodies as probes to quantify the energetic contributions of ligand binding to conformational changes in proteins. PMID:29321208
Mutations in Escherichia coli Polyphosphate Kinase That Lead to Dramatically Increased In Vivo Polyphosphate Levels. PMID:29311274
Affinity maturation of a portable Fab-RNA module for chaperone-assisted RNA crystallography. PMID:29309709
Structural, Biochemical, and Evolutionary Characterizations of Glyoxylate/Hydroxypyruvate Reductases Show Their Division into Two Distinct Subfamilies. PMID:29309127
Atomic Structure of Type VI Contractile Sheath from Pseudomonas aeruginosa. PMID:29307484
A structurally dynamic N-terminal region drives function of the staphylococcal peroxidase inhibitor (SPIN). PMID:29306874
Computational Insights into the Interactions between Calmodulin and the c/nSH2 Domains of p85α Regulatory Subunit of PI3Kα: Implication for PI3Kα Activation by Calmodulin. PMID:29300353
The protease GtgE from Salmonella exclusively targets inactive Rab GTPases. PMID:29298974
CDC42 binds PAK4 via an extended GTPase-effector interface. PMID:29295922
Crystal Structure of Bicc1 SAM Polymer and Mapping of Interactions between the Ciliopathy-Associated Proteins Bicc1, ANKS3, and ANKS6. PMID:29290488
Structure of the G119S Mutant Acetylcholinesterase of the Malaria Vector Anopheles gambiae Reveals Basis of Insecticide Resistance. PMID:29276037
A mutant of phosphomannomutase1 retains full enzymatic activity, but is not activated by IMP: Possible implications for the disease PMM2-CDG. PMID:29261720
Structures of the L27 Domain of Disc Large Homologue 1 Protein Illustrate a Self-Assembly Module. PMID:29261291
Allosteric modulation of protein-protein interactions by individual lipid binding events. PMID:29259178
Complementarity determining regions and frameworks contribute to the disulfide bond independent folding of intrinsically stable scFv. PMID:29253024
Competitive Inhibitors Unveil Structure/Function Relationships in Human D-Amino Acid Oxidase. PMID:29250527
Diverse NADase effector families mediate interbacterial antagonism via the type VI secretion system. PMID:29237732
Nucleotide- and Mal3-dependent changes in fission yeast microtubules suggest a structural plasticity view of dynamics. PMID:29235477
Molecular and functional characterization of ferredoxin NADP(H) oxidoreductase from Gracilaria chilensis and its complex with ferredoxin. PMID:29221464
Structural insights into ankyrin repeat-mediated recognition of the kinesin motor protein KIF21A by KANK1, a scaffold protein in focal adhesion. PMID:29217769
Structural basis for methylphosphonate biosynthesis. PMID:29217579
Crystal structures of murine and human Histamine-Releasing Factor (HRF/TCTP) and a model for HRF dimerisation in mast cell activation. PMID:29216544
Active-site plasticity revealed in the asymmetric dimer of AnPrx6 the 1-Cys peroxiredoxin and molecular chaperone from Anabaena sp. PCC 7210. PMID:29215017
The crystal structure of pseudokinase PEAK1 (Sugen kinase 269) reveals an unusual catalytic cleft and a novel mode of kinase fold dimerization. PMID:29212708
Identifying functionally informative evolutionary sequence profiles. PMID:29211823
Molecular evolution of an oligomeric biocatalyst functioning in lysine biosynthesis. PMID:29204887
Swit_4259, an acetoacetate decarboxylase-like enzyme from Sphingomonas wittichii RW1. PMID:29199988
Crystal structure of a pyridoxal 5'-phosphate-dependent aspartate racemase derived from the bivalve mollusc Scapharca broughtonii. PMID:29199985
Structure of the Bacillus anthracis dTDP-L-rhamnose-biosynthetic enzyme dTDP-4-dehydrorhamnose reductase (RfbD). PMID:29199984
Concurrent structural and biophysical traits link with immunoglobulin light chains amyloid propensity. PMID:29196671
Biochemical and Structural Analysis of Substrate Specificity of a Phenylalanine Ammonia-Lyase. PMID:29196539
Diversity of Nicotinic Acetylcholine Receptor Positive Allosteric Modulators Revealed by Mutagenesis and a Revised Structural Model. PMID:29196491
Crystal structure of a tripartite complex between C3dg, C-terminal domains of factor H and OspE of Borrelia burgdorferi. PMID:29190743
Structural and Functional Basis for Targeting Campylobacter jejuni Agmatine Deiminase To Overcome Antibiotic Resistance. PMID:29190068
Structural basis of respiratory syncytial virus subtype-dependent neutralization by an antibody targeting the fusion glycoprotein. PMID:29187732
The dUTPase of white spot syndrome virus assembles its active sites in a noncanonical manner. PMID:29187596
Stu2 uses a 15-nm parallel coiled coil for kinetochore localization and concomitant regulation of the mitotic spindle. PMID:29187574
Conformational dynamism for DNA interaction in the Salmonella RcsB response regulator. PMID:29186528
A hereditary spastic paraplegia-associated atlastin variant exhibits defective allosteric coupling in the catalytic core. PMID:29180453
A neutralizing antibody that blocks delivery of the enzymatic cargo of Clostridium difficile toxin TcdB into host cells. PMID:29180448
Structures and enzymatic mechanisms of phycobiliprotein lyases CpcE/F and PecE/F. PMID:29180420
Conservation of the Enzyme-Coenzyme Interfaces in FAD and NADP Binding Adrenodoxin Reductase-A Ubiquitous Enzyme. PMID:29177972
Design and applications of a clamp for Green Fluorescent Protein with picomolar affinity. PMID:29176615
The molecular basis of phosphite and hypophosphite recognition by ABC-transporters. PMID:29170493
Data on crystal organization in the structure of the Fab fragment from the NIST reference antibody, RM 8671. PMID:29167817
Rare PfCSP C-terminal antibodies induced by live sporozoite vaccination are ineffective against malaria infection. PMID:29167197
Structural basis of the therapeutic anti-PD-L1 antibody atezolizumab. PMID:29163822
TYK2-induced phosphorylation of Y640 suppresses STAT3 transcriptional activity. PMID:29162862
Structural basis for the assembly of the Ragulator-Rag GTPase complex. PMID:29158492
PDB-wide identification of biological assemblies from conserved quaternary structure geometry. PMID:29155427
Structural Basis for DNA Recognition of a Single-stranded DNA-binding Protein from Enterobacter Phage Enc34. PMID:29138440
Structural remodeling and oligomerization of human cathelicidin on membranes suggest fibril-like structures as active species. PMID:29133814
Crystal Structure of Borrelia turicatae protein, BTA121, a differentially regulated gene in the tick-mammalian transmission cycle of relapsing fever spirochetes. PMID:29127407
Unique architecture of thermophilic archaeal virus APBV1 and its genome packaging. PMID:29127347
Structural basis of arrestin-3 activation and signaling. PMID:29127291
PDBe: towards reusable data delivery infrastructure at protein data bank in Europe. PMID:29126160
The potential of hexatungstotellurate(VI) to induce a significant entropic gain during protein crystallization. PMID:29123675
Structural and biochemical analysis of atypically low dephosphorylating activity of human dual-specificity phosphatase 28. PMID:29121083
Crystal Structure of the Full-Length Feline Immunodeficiency Virus Capsid Protein Shows an N-Terminal β-Hairpin in the Absence of N-Terminal Proline. PMID:29120364
Mycobacterium tuberculosis Rv3651 is a triple sensor-domain protein. PMID:29119630
Correlation between the molecular effects of mutations at the dimer interface of alanine-glyoxylate aminotransferase leading to primary hyperoxaluria type I and the cellular response to vitamin B6. PMID:29110180
Crystal structure of tripartite-type ABC transporter MacB from Acinetobacter baumannii. PMID:29109439
Insights into Biofilm Dispersal Regulation from the Crystal Structure of the PAS-GGDEF-EAL Region of RbdA from Pseudomonas aeruginosa. PMID:29109186
KLK5 induces shedding of DPP4 from circulatory Th17 cells in type 2 diabetes. PMID:29107298
Introducing the new bacterial branch of the RNase A superfamily. PMID:29099294
Structure of the staphylococcal enterotoxin B vaccine candidate S19 showing eliminated superantigen activity. PMID:29095152
Structural dissection of human metapneumovirus phosphoprotein using small angle x-ray scattering. PMID:29093501
A 3.0-Angstrom Resolution Cryo-Electron Microscopy Structure and Antigenic Sites of Coxsackievirus A6-Like Particles. PMID:29093091
Coordination and redox state-dependent structural changes of the heme-based oxygen sensor AfGcHK associated with intraprotein signal transduction. PMID:29092908
Protocadherin cis-dimer architecture and recognition unit diversity. PMID:29087338
Structure of SgK223 pseudokinase reveals novel mechanisms of homotypic and heterotypic association. PMID:29079850
Exploitation of an iron transporter for bacterial protein antibiotic import. PMID:29078392
A unique surface on Pat1 C-terminal domain directly interacts with Dcp2 decapping enzyme and Xrn1 5'-3' mRNA exonuclease in yeast. PMID:29078363
Reverse chemical ecology: Olfactory proteins from the giant panda and their interactions with putative pheromones and bamboo volatiles. PMID:29078359
Molecular Dynamics Simulations and Dynamic Network Analysis Reveal the Allosteric Unbinding of Monobody to H-Ras Triggered by R135K Mutation. PMID:29072601
Assessment of protein assembly prediction in CASP12. PMID:29071742
Structural basis for the functional role of the Shu complex in homologous recombination. PMID:29069504
Norovirus Escape from Broadly Neutralizing Antibodies Is Limited to Allostery-Like Mechanisms. PMID:29062895
Functional and Structural Studies of a Multidomain Alginate Lyase from Persicobacter sp. CCB-QB2. PMID:29057942
A General Strategy for Discovery of Inhibitors and Activators of RING and U-box E3 Ligases with Ubiquitin Variants. PMID:29053960
Structural and functional studies of SAV0551 from Staphylococcus aureus as a chaperone and glyoxalase III. PMID:29046369
Molecular basis for inner kinetochore configuration through RWD domain-peptide interactions. PMID:29046335
APOBEC3H structure reveals an unusual mechanism of interaction with duplex RNA. PMID:29044109
Three-dimensional context rather than NLS amino acid sequence determines importin α subtype specificity for RCC1. PMID:29042532
Unveiling a Drift Resistant Cryptotope within Marburgvirus Nucleoprotein Recognized by Llama Single-Domain Antibodies. PMID:29038656
A structural model of flagellar filament switching across multiple bacterial species. PMID:29038601
Packing topology in crystals of proteins and small molecules: a comparison. PMID:29038549
Structural plasticity of the N-terminal capping helix of the TPR domain of kinesin light chain. PMID:29036226
Protein-protein interaction specificity is captured by contact preferences and interface composition. PMID:29028884
Binding Direction-Based Two-Dimensional Flattened Contact Area Computing Algorithm for Protein-Protein Interactions. PMID:29027921
Structure of RNA polymerase bound to ribosomal 30S subunit. PMID:29027901
Identifying direct contacts between protein complex subunits from their conditional dependence in proteomics datasets. PMID:29023445
The N-terminal domains of FLASH and Lsm11 form a 2:1 heterotrimer for histone pre-mRNA 3'-end processing. PMID:29020104
Structure, activity and thermostability investigations of OXA-163, OXA-181 and OXA-245 using biochemical analysis, crystal structures and differential scanning calorimetry analysis. PMID:28994407
Applications of sequence coevolution in membrane protein biochemistry. PMID:28993150
Contributions and Future Directions for Structural Biology in the Study of Allergens. PMID:28992615
Structural basis for GABAA receptor potentiation by neurosteroids. PMID:28991263
Structural Basis for a Safety-Belt Mechanism That Anchors Condensin to Chromosomes. PMID:28988770
L-Asparaginase of Leishmania donovani: Metabolic target and its role in Amphotericin B resistance. PMID:28988014
Selenoprotein MsrB1 deficiency exacerbates acetaminophen-induced hepatotoxicity via increased oxidative damage. PMID:28986131
Protein-protein interactions leave evolutionary footprints: High molecular coevolution at the core of interfaces. PMID:28980349
Structural insights into RapZ-mediated regulation of bacterial amino-sugar metabolism. PMID:28977623
Intrinsic thermodynamics of high affinity inhibitor binding to recombinant human carbonic anhydrase IV. PMID:28975383
Molecular architecture of the PBP2-MreC core bacterial cell wall synthesis complex. PMID:28974686
Structure of a novel antibacterial toxin that exploits elongation factor Tu to cleave specific transfer RNAs. PMID:28973472
Structural insights into GDP-mediated regulation of a bacterial acyl-CoA thioesterase. PMID:28972175
Structural analyses of the MazEF4 toxin-antitoxin pair in Mycobacterium tuberculosis provide evidence for a unique extracellular death factor. PMID:28972145
Molecular basis of human CD22 function and therapeutic targeting. PMID:28970495
IntPred: a structure-based predictor of protein-protein interaction sites. PMID:28968673
Structural Basis of Catalysis in the Bacterial Monoterpene Synthases Linalool Synthase and 1,8-Cineole Synthase. PMID:28966840
Biophysical characterization and structure of the Fab fragment from the NIST reference antibody, RM 8671. PMID:28965821
Conformational features of the Staphylococcus aureus AgrA-promoter interactions rationalize quorum-sensing triggered gene expression. PMID:28955870
Crystal Structures of Two Immune Complexes Identify Determinants for Viral Infectivity and Type-Specific Neutralization of Human Papillomavirus. PMID:28951471
Crystal structure of the Legionella pneumophila Lpg2936 in complex with the cofactor S-adenosyl-L-methionine reveals novel insights into the mechanism of RsmE family methyltransferases. PMID:28940762
Structures of foot and mouth disease virus pentamers: Insight into capsid dissociation and unexpected pentamer reassociation. PMID:28937999
The bacterial meta-cleavage hydrolase LigY belongs to the amidohydrolase superfamily, not to the α/β-hydrolase superfamily. PMID:28935670
The fused SnoaL_2 domain in the Mycobacterium tuberculosis sigma factor σJ modulates promoter recognition. PMID:28934483
Crystal structure of an engineered, HIV-specific recombinase for removal of integrated proviral DNA. PMID:28934476
Crystal structures of eukaryote glycosyltransferases reveal biologically relevant enzyme homooligomers. PMID:28932871
IL-1 Family Cytokines Use Distinct Molecular Mechanisms to Signal through Their Shared Co-receptor. PMID:28930661
In silico modeling of the cryptic E2∼ubiquitin-binding site of E6-associated protein (E6AP)/UBE3A reveals the mechanism of polyubiquitin chain assembly. PMID:28924046
Rift Valley fever phlebovirus NSs protein core domain structure suggests molecular basis for nuclear filaments. PMID:28915104
Forty years of collaborative computational crystallography. PMID:28901632
Atomic structures of Coxsackievirus A6 and its complex with a neutralizing antibody. PMID:28894095
Convergent evolution involving dimeric and trimeric dUTPases in pathogenicity island mobilization. PMID:28892519
Dockground: A comprehensive data resource for modeling of protein complexes. PMID:28891124
Structures of Leishmania Fructose-1,6-Bisphosphatase Reveal Species-Specific Differences in the Mechanism of Allosteric Inhibition. PMID:28882541
Stereotyped antibody responses target posttranslationally modified gluten in celiac disease. PMID:28878138
Structural insights into the interaction of the conserved mammalian proteins GAPR-1 and Beclin 1, a key autophagy protein. PMID:28876241
Structures of Medicago truncatula L-Histidinol Dehydrogenase Show Rearrangements Required for NAD+ Binding and the Cofactor Positioned to Accept a Hydride. PMID:28874718
Neutralization of Human Interleukin 23 by Multivalent Nanobodies Explained by the Structure of Cytokine-Nanobody Complex. PMID:28871249
Effect of amino acid mutations on the conformational dynamics of amyloidogenic immunoglobulin light-chains: A combined NMR and in silico study. PMID:28871194
Unitary Properties of AMPA Receptors with Reduced Desensitization. PMID:28863863
Structural and functional insights into the interaction between the Cas family scaffolding protein p130Cas and the focal adhesion-associated protein paxillin. PMID:28860193
Structure-function analysis of the Fusarium oxysporum Avr2 effector allows uncoupling of its immune-suppressing activity from recognition. PMID:28857169
Bioinformatics comparisons of RNA-binding proteins of pathogenic and non-pathogenic Escherichia coli strains reveal novel virulence factors. PMID:28836963
Structural Transitions of the Conserved and Metastable Hantaviral Glycoprotein Envelope. PMID:28835498
The human IL-17A/F heterodimer: a two-faced cytokine with unique receptor recognition properties. PMID:28827714
Crystal structures reveal metal-binding plasticity at the metallo-β-lactamase active site of PqqB from Pseudomonas putida. PMID:28825148
Bivalent Llama Single-Domain Antibody Fragments against Tumor Necrosis Factor Have Picomolar Potencies due to Intramolecular Interactions. PMID:28824615
Ribonucleotide Reductases from Bifidobacteria Contain Multiple Conserved Indels Distinguishing Them from All Other Organisms: In Silico Analysis of the Possible Role of a 43 aa Bifidobacteria-Specific Insert in the Class III RNR Homolog. PMID:28824557
Structural Mechanism for Modulation of Synaptic Neuroligin-Neurexin Signaling by MDGA Proteins. PMID:28817804
Structural Characterization of Acidic M17 Leucine Aminopeptidases from the TriTryps and Evaluation of Their Role in Nutrient Starvation in Trypanosoma brucei. PMID:28815215
Modeling of RAS complexes supports roles in cancer for less studied partners. PMID:28815022
The primed SNARE-complexin-synaptotagmin complex for neuronal exocytosis. PMID:28813412
Biophysical and Computational Studies of the vCCI:vMIP-II Complex. PMID:28813018
On the potential alternate binding change mechanism in a dimeric structure of Pyruvate Phosphate Dikinase. PMID:28808308
Structural characterization of CAS SH3 domain selectivity and regulation reveals new CAS interaction partners. PMID:28808245
Structural analyses of the bacterial primosomal protein DnaB reveal that it is a tetramer and forms a complex with a primosomal re-initiation protein. PMID:28808061
Immune evasion by a staphylococcal inhibitor of myeloperoxidase. PMID:28808028
Crystal Structure and Substrate Specificity Modification of Acetyl Xylan Esterase from Aspergillus luchuensis. PMID:28802264
Structural transitions in conserved, ordered Beclin 1 domains essential to regulating autophagy. PMID:28798234
Catabolism of the Cholesterol Side Chain in Mycobacterium tuberculosis Is Controlled by a Redox-Sensitive Thiol Switch. PMID:28786661
A camelid single-domain antibody neutralizes botulinum neurotoxin A by blocking host receptor binding. PMID:28785006
Potent and broad HIV-neutralizing antibodies in memory B cells and plasma. PMID:28783671
Anthranilate phosphoribosyltransferase from the hyperthermophilic archaeon Thermococcus kodakarensis shows maximum activity with zinc and forms a unique dimeric structure. PMID:28781961
Structural basis of TIR-domain-assembly formation in MAL- and MyD88-dependent TLR4 signaling. PMID:28759049
Crystal structure of master biofilm regulator CsgD regulatory domain reveals an atypical receiver domain. PMID:28758290
Solution NMR structure of the TRIM21 B-box2 and identification of residues involved in its interaction with the RING domain. PMID:28753623
Biophysical characterization of the calmodulin-like domain of Plasmodium falciparum calcium dependent protein kinase 3. PMID:28746405
Structure of Chorismate Mutase-like Domain of DAHPS from Bacillus subtilis Complexed with Novel Inhibitor Reveals Conformational Plasticity of Active Site. PMID:28743924
Structural basis for dolichylphosphate mannose biosynthesis. PMID:28743912
Catalytic Mechanism of the Hotdog-Fold Thioesterase PA1618 Revealed by X-ray Structure Determination of a Substrate-Bound Oxygen Ester Analogue Complex. PMID:28741300
An in-silico glimpse into the pH dependent structural changes of T7 RNA polymerase: a protein with simplicity. PMID:28740191
Systematic studies of the interactions between a model polyphenol compound and microbial β-glucosidases. PMID:28727856
Mechanism for G2 phase-specific nuclear export of the kinetochore protein CENP-F. PMID:28723232
Cryo-EM structures of the ATP-bound Vps4E233Q hexamer and its complex with Vta1 at near-atomic resolution. PMID:28714467
Biophysical investigation of type A PutAs reveals a conserved core oligomeric structure. PMID:28710792
Use of a neutralizing antibody helps identify structural features critical for binding of Clostridium difficile toxin TcdA to the host cell surface. PMID:28705932
Open and closed structures reveal allostery and pliability in the HIV-1 envelope spike. PMID:28700571
Antibody-induced uncoating of human rhinovirus B14. PMID:28696310
1.8 Å resolution crystal structure of the carbapenem intrinsic resistance protein CarF. PMID:28695855
Crystal structure of the N-terminal domain of VqsR from Pseudomonas aeruginosa at 2.1 Å resolution. PMID:28695853
The multidrug-resistance transporter MdfA from Escherichia coli: crystallization and X-ray diffraction analysis. PMID:28695852
Crystal structure of a β-aminopeptidase from an Australian Burkholderia sp. PMID:28695846
Self-assembled α-Tocopherol Transfer Protein Nanoparticles Promote Vitamin E Delivery Across an Endothelial Barrier. PMID:28694484
Structure and evolution of ENTH and VHS/ENTH-like domains in tepsin. PMID:28691777
Conformational Landscape of the p28-Bound Human Proteasome Regulatory Particle. PMID:28689658
Assessment of the protein interaction between coagulation factor XII and corn trypsin inhibitor by molecular docking and biochemical validation. PMID:28688220
Frutapin, a lectin from Artocarpus incisa (breadfruit): cloning, expression and molecular insights. PMID:28684550
A novel function for globulin in sequestering plant hormone: Crystal structure of Wrightia tinctoria 11S globulin in complex with auxin. PMID:28680092
Anti-citrullinated protein antibodies cause arthritis by cross-reactivity to joint cartilage. PMID:28679953
Modulation of the FMRFamide-gated Na+ channel by external Ca2. PMID:28674755
Quaternary structure is an essential component that contributes to the sophisticated allosteric regulation mechanism in a key enzyme from Mycobacterium tuberculosis. PMID:28665948
Biochemical Characterization and Structural Basis of Reactivity and Regioselectivity Differences between Burkholderia thailandensis and Burkholderia glumae 1,6-Didesmethyltoxoflavin N-Methyltransferase. PMID:28665591
Functional and dynamic polymerization of the ALS-linked protein TDP-43 antagonizes its pathologic aggregation. PMID:28663553
Adenosine Monophosphate Binding Stabilizes the KTN Domain of the Shewanella denitrificans Kef Potassium Efflux System. PMID:28656748
A new approach for generating bispecific antibodies based on a common light chain format and the stable architecture of human immunoglobulin G1. PMID:28655766
Phosphate steering by Flap Endonuclease 1 promotes 5'-flap specificity and incision to prevent genome instability. PMID:28653660
Interaction between the PH and START domains of ceramide transfer protein competes with phosphatidylinositol 4-phosphate binding by the PH domain. PMID:28652409
Crystal Structure of Chicken γS-Crystallin Reveals Lattice Contacts with Implications for Function in the Lens and the Evolution of the βγ-Crystallins. PMID:28648607
Molecular Mechanism of MDGA1: Regulation of Neuroligin 2:Neurexin Trans-synaptic Bridges. PMID:28641112
Structure of CC Chemokine Receptor 5 with a Potent Chemokine Antagonist Reveals Mechanisms of Chemokine Recognition and Molecular Mimicry by HIV. PMID:28636951
Convergent immunological solutions to Argentine hemorrhagic fever virus neutralization. PMID:28630325
S-adenosyl-L-homocysteine hydrolase from a hyperthermophile (Thermotoga maritima) is expressed in Escherichia coli in inactive form - Biochemical and structural studies. PMID:28629859
Structural Basis of Egg Coat-Sperm Recognition at Fertilization. PMID:28622512
9Å structure of the COPI coat reveals that the Arf1 GTPase occupies two contrasting molecular environments. PMID:28621666
Streptococcus pyogenes quinolinate-salvage pathway-structural and functional studies of quinolinate phosphoribosyl transferase and NH3 -dependent NAD+ synthetase. PMID:28618168
Structural studies of viperin, an antiviral radical SAM enzyme. PMID:28607080
The Enzyme Activity and Substrate Specificity of Two Major Cinnamyl Alcohol Dehydrogenases in Sorghum (Sorghum bicolor), SbCAD2 and SbCAD4. PMID:28606901
Effects of myosin variants on interacting-heads motif explain distinct hypertrophic and dilated cardiomyopathy phenotypes. PMID:28606303
IgG Fc domains that bind C1q but not effector Fcγ receptors delineate the importance of complement-mediated effector functions. PMID:28604720
Timing and Reset Mechanism of GTP Hydrolysis-Driven Conformational Changes of Atlastin. PMID:28602821
Insights into Hunter syndrome from the structure of iduronate-2-sulfatase. PMID:28593992
Tethering not required: the glucocorticoid receptor binds directly to activator protein-1 recognition motifs to repress inflammatory genes. PMID:28591827
De novo non-synonymous TBL1XR1 mutation alters Wnt signaling activity. PMID:28588275
Structural basis of HypK regulating N-terminal acetylation by the NatA complex. PMID:28585574
Crystal structures of human Fabs targeting the Bexsero meningococcal vaccine antigen NHBA. PMID:28580917
Insights into PG-binding, conformational change, and dimerization of the OmpA C-terminal domains from Salmonella enterica serovar Typhimurium and Borrelia burgdorferi. PMID:28580643
Functional details of the Mycobacterium tuberculosis VapBC26 toxin-antitoxin system based on a structural study: insights into unique binding and antibiotic peptides. PMID:28575388
Databases, Repositories, and Other Data Resources in Structural Biology. PMID:28573593
The "Sticky Patch" Model of Crystallization and Modification of Proteins for Enhanced Crystallizability. PMID:28573570
How an alloreactive T-cell receptor achieves peptide and MHC specificity. PMID:28572406
Circulatory zinc transport is controlled by distinct interdomain sites on mammalian albumins. PMID:28567254
Structural Basis for Regulation of ESCRT-III Complexes by Lgd. PMID:28564595
Crystal structure of the thioesterification conformation of Bacillus subtilis o-succinylbenzoyl-CoA synthetase reveals a distinct substrate-binding mode. PMID:28559280
Fe65-PTB2 Dimerization Mimics Fe65-APP Interaction. PMID:28553201
Discovery of novel inhibitors for Leishmania nucleoside diphosphatase kinase (NDK) based on its structural and functional characterization. PMID:28551817
Structure and Dimerization of IreB, a Negative Regulator of Cephalosporin Resistance in Enterococcus faecalis. PMID:28551334
Zinc and the iron donor frataxin regulate oligomerization of the scaffold protein to form new Fe-S cluster assembly centers. PMID:28548666
Potent and selective inhibition of pathogenic viruses by engineered ubiquitin variants. PMID:28542609
The LOTUS domain is a conserved DEAD-box RNA helicase regulator essential for the recruitment of Vasa to the germ plasm and nuage. PMID:28536148
Recognition of EGF-like domains by the Notch-modifying O-fucosyltransferase POFUT1. PMID:28530709
The origin and evolution of human glutaminases and their atypical C-terminal ankyrin repeats. PMID:28526749
Crystal structure of TAZ-TEAD complex reveals a distinct interaction mode from that of YAP-TEAD complex. PMID:28515457
Conformational Flexibility in the Immunoglobulin-Like Domain of the Hepatitis C Virus Glycoprotein E2. PMID:28512091
Structural insights into a 20.8-kDa tegumental-allergen-like (TAL) protein from Clonorchis sinensis. PMID:28496122
Structure and Spectroscopy of Alkene-Cleaving Dioxygenases Containing an Atypically Coordinated Non-Heme Iron Center. PMID:28493664
Selectivity determinants of GPCR-G-protein binding. PMID:28489817
Computational dissection of allosteric inhibition of the SH2 domain of Bcr-Abl kinase by the monobody inhibitor AS25. PMID:28488190
Determining Complex Structures using Docking Method with Single Particle Scattering Data. PMID:28487857
Structure-function analysis of RBP-J-interacting and tubulin-associated (RITA) reveals regions critical for repression of Notch target genes. PMID:28487372
ProteinsPlus: a web portal for structure analysis of macromolecules. PMID:28472372
Carbohydrate recognition by the rhamnose-binding lectin SUL-I with a novel three-domain structure isolated from the venom of globiferous pedicellariae of the flower sea urchin Toxopneustes pileolus. PMID:28470711
Crystal structure of the essential biotin-dependent carboxylase AccA3 from Mycobacterium tuberculosis. PMID:28469974
A Polymerization-Associated Structural Switch in FtsZ That Enables Treadmilling of Model Filaments. PMID:28465423
Subnanometre-resolution structure of the doublet microtubule reveals new classes of microtubule-associated proteins. PMID:28462916
Crystal structure of APOBEC3A bound to single-stranded DNA reveals structural basis for cytidine deamination and specificity. PMID:28452355
Allosteric mechanism of action of the therapeutic anti-IgE antibody omalizumab. PMID:28438838
Unraveling self-assembly pathways of the 468-kDa proteolytic machine TET2. PMID:28435872
The Lon protease-like domain in the bacterial RecA paralog RadA is required for DNA binding and repair. PMID:28432121
Ion- and water-binding sites inside an occluded hourglass pore of a trimeric intracellular cation (TRIC) channel. PMID:28431535
Small methyltransferase RlmH assembles a composite active site to methylate a ribosomal pseudouridine. PMID:28428565
Leishmania donovani tyrosyl-tRNA synthetase structure in complex with a tyrosyl adenylate analog and comparisons with human and protozoan counterparts. PMID:28427904
Soaking suggests "alternative facts": Only co-crystallization discloses major ligand-induced interface rearrangements of a homodimeric tRNA-binding protein indicating a novel mode-of-inhibition. PMID:28419165
Symmetry based assembly of a 2 dimensional protein lattice. PMID:28419162
Using the pimeloyl-CoA synthetase adenylation fold to synthesize fatty acid thioesters. PMID:28414710
SnoN Stabilizes the SMAD3/SMAD4 Protein Complex. PMID:28397834
Prospecting Biotechnologically-Relevant Monooxygenases from Cold Sediment Metagenomes: An In Silico Approach. PMID:28397770
Vesicular stomatitis virus N protein-specific single-domain antibody fragments inhibit replication. PMID:28396572
Structural insights into the production of 3-hydroxypropionic acid by aldehyde dehydrogenase from Azospirillum brasilense. PMID:28393833
Hybrid Mass Spectrometry Approaches to Determine How L-Histidine Feedback Regulates the Enzyzme MtATP-Phosphoribosyltransferase. PMID:28392260
Structure of the WipA protein reveals a novel tyrosine protein phosphatase effector from Legionella pneumophila. PMID:28389563
Five Fatty Aldehyde Dehydrogenase Enzymes from Marinobacter and Acinetobacter spp. and Structural Insights into the Aldehyde Binding Pocket. PMID:28389542
Characterization and mutational analysis of a nicotinamide mononucleotide deamidase from Agrobacterium tumefaciens showing high thermal stability and catalytic efficiency. PMID:28388636
Differential CLE peptide perception by plant receptors implicated from structural and functional analyses of TDIF-TDR interactions. PMID:28384649
The structure and polymerase-recognition mechanism of the crucial adaptor protein AND-1 in the human replisome. PMID:28381552
Structural basis for a novel type of cytokinin-activating protein. PMID:28374778
Human apo-SRP72 and SRP68/72 complex structures reveal the molecular basis of protein translocation. PMID:28369529
Crystal structure of a small heat-shock protein from Xylella fastidiosa reveals a distinct high-order structure. PMID:28368281
Structure activity study of carbonic anhydrase IX: Selective inhibition with ureido-substituted benzenesulfonamides. PMID:28363153
Alteration of the α1β2/α2β1 subunit interface contributes to the increased hemoglobin-oxygen affinity of high-altitude deer mice. PMID:28362841
Rational mutagenesis by engineering disulphide bonds improves Kluyveromyces lactis beta-galactosidase for high-temperature industrial applications. PMID:28361909
IgE binds asymmetrically to its B cell receptor CD23. PMID:28361904
Structural reconstruction of protein ancestry. PMID:28356519
Crystal structure of U2 snRNP SF3b components: Hsh49p in complex with Cus1p-binding domain. PMID:28348170
Structure of the Cyanuric Acid Hydrolase TrzD Reveals Product Exit Channel. PMID:28345631
The trimer interface in the quaternary structure of the bifunctional prokaryotic FAD synthetase from Corynebacterium ammoniagenes. PMID:28341845
The IFN-λ-IFN-λR1-IL-10Rβ Complex Reveals Structural Features Underlying Type III IFN Functional Plasticity. PMID:28329704
Structural insights into the regulation of Bacillus subtilis SigW activity by anti-sigma RsiW. PMID:28319136
Structures of human O-GlcNAcase and its complexes reveal a new substrate recognition mode. PMID:28319083
Insights into Rad3 kinase recruitment from the crystal structure of the DNA damage checkpoint protein Rad26. PMID:28314775
Identification of C3b-Binding Small-Molecule Complement Inhibitors Using Cheminformatics. PMID:28298523
Structural insights into the γ-lactamase activity and substrate enantioselectivity of an isochorismatase-like hydrolase from Microbacterium hydrocarbonoxydans. PMID:28295028
Antibiotic Capture by Bacterial Lipocalins Uncovers an Extracellular Mechanism of Intrinsic Antibiotic Resistance. PMID:28292982
Proteolysis of truncated hemolysin A yields a stable dimerization interface. PMID:28291749
Site-to-site interdomain communication may mediate different loss-of-function mechanisms in a cancer-associated NQO1 polymorphism. PMID:28291250
Structural Basis of Eco1-Mediated Cohesin Acetylation. PMID:28290497
Structural basis of PROTAC cooperative recognition for selective protein degradation. PMID:28288108
Two alternative binding mechanisms connect the protein translocation Sec71-Sec72 complex with heat shock proteins. PMID:28286332
Allosteric modulation of peroxisomal membrane protein recognition by farnesylation of the peroxisomal import receptor PEX19. PMID:28281558
Structural basis of homo- and heterotrimerization of collagen I. PMID:28281531
Structural and functional characterization of a ubiquitin variant engineered for tight and specific binding to an alpha-helical ubiquitin interacting motif. PMID:28276594
Long-range allosteric signaling in red light-regulated diguanylyl cyclases. PMID:28275738
Accurate model annotation of a near-atomic resolution cryo-EM map. PMID:28270620
Resolving the cofactor-binding site in the proline biosynthetic enzyme human pyrroline-5-carboxylate reductase 1. PMID:28258219
Notch-Jagged complex structure implicates a catch bond in tuning ligand sensitivity. PMID:28254785
Chloroplast Preproteins Bind to the Dimer Interface of the Toc159 Receptor during Import. PMID:28250068
Identification of Biomarkers for Resistance to Fusarium oxysporum f. sp. cubense Infection and in Silico Studies in Musa paradisiaca Cultivar Puttabale through Proteomic Approach. PMID:28248219
Crystal structure of acetylcholinesterase catalytic subunits of the malaria vector Anopheles gambiae. PMID:28247978
Stilbene epoxidation and detoxification in a Photorhabdus luminescens-nematode symbiosis. PMID:28246174
Surface induced dissociation as a tool to study membrane protein complexes. PMID:28243658
Functional and Structural Analysis of Programmed C-Methylation in the Biosynthesis of the Fungal Polyketide Citrinin. PMID:28238725
Catalytic competence, structure and stability of the cancer-associated R139W variant of the human NAD(P)H:quinone oxidoreductase 1 (NQO1). PMID:28236663
Structural and biochemical studies on Vibrio cholerae Hsp31 reveals a novel dimeric form and Glutathione-independent Glyoxalase activity. PMID:28235098
A three-way approach for protein function classification. PMID:28234929
Quaternary contact in the initial interaction of CD4 with the HIV-1 envelope trimer. PMID:28218750
Novel molecular, structural and evolutionary characteristics of the phosphoketolases from bifidobacteria and Coriobacteriales. PMID:28212383
Structure of a LOV protein in apo-state and implications for construction of LOV-based optical tools. PMID:28211532
Atomic structure of granulin determined from native nanocrystalline granulovirus using an X-ray free-electron laser. PMID:28202732
A key centriole assembly interaction interface between human PLK4 and STIL appears to not be conserved in flies. PMID:28202467
Crystal structures of the Arabidopsis thaliana organellar RNA editing factors MORF1 and MORF9. PMID:28201607
Mechanistic insight into the substrate specificity of 1,2-β-oligoglucan phosphorylase from Lachnoclostridium phytofermentans. PMID:28198470
Structural insights unravel the zymogenic mechanism of the virulence factor gingipain K from Porphyromonas gingivalis, a causative agent of gum disease from the human oral microbiome. PMID:28196869
A conformational switch regulates the ubiquitin ligase HUWE1. PMID:28193319
Benchmarking Quantum Mechanics/Molecular Mechanics (QM/MM) Methods on the Thymidylate Synthase-Catalyzed Hydride Transfer. PMID:28192669
Myroilysin Is a New Bacterial Member of the M12A Family of Metzincin Metallopeptidases and Is Activated by a Cysteine Switch Mechanism. PMID:28188295
Cyclin F/FBXO1 Interacts with HIV-1 Viral Infectivity Factor (Vif) and Restricts Progeny Virion Infectivity by Ubiquitination and Proteasomal Degradation of Vif Protein through SCFcyclin F E3 Ligase Machinery. PMID:28184007
Structural, mechanistic and functional insight into gliotoxin bis-thiomethylation in Aspergillus fumigatus. PMID:28179499
Structural Insights into the Broad Substrate Specificity of a Novel Endoglycoceramidase I Belonging to a New Subfamily of GH5 Glycosidases. PMID:28179425
Nmd3 is a structural mimic of eIF5A, and activates the cpGTPase Lsg1 during 60S ribosome biogenesis. PMID:28179369
Structure of Methylobacterium extorquens malyl-CoA lyase: CoA-substrate binding correlates with domain shift. PMID:28177317
Structural basis for redox sensitivity in Corynebacterium glutamicum diaminopimelate epimerase: an enzyme involved in l-lysine biosynthesis. PMID:28176858
Improving protein-protein interaction prediction using evolutionary information from low-quality MSAs. PMID:28166227
Structural analysis and evolution of specificity of the SUMO UFD E1-E2 interactions. PMID:28165030
A universal computational model for predicting antigenic variants of influenza A virus based on conserved antigenic structures. PMID:28165025
Cytidine deaminase efficiency of the lentiviral viral restriction factor APOBEC3C correlates with dimerization. PMID:28158858
Gene polymorphism linked to increased asthma and IBD risk alters gasdermin-B structure, a sulfatide and phosphoinositide binding protein. PMID:28154144
Crystal Structure and Catalytic Mechanism of CouO, a Versatile C-Methyltransferase from Streptomyces rishiriensis. PMID:28152088
Discovery of a junctional epitope antibody that stabilizes IL-6 and gp80 protein:protein interaction and modulates its downstream signaling. PMID:28134246
The Structure of an Archaeal β-Glucosaminidase Provides Insight into Glycoside Hydrolase Evolution. PMID:28130448
Interference of the complex between NCS-1 and Ric8a with phenothiazines regulates synaptic function and is an approach for fragile X syndrome. PMID:28119500
MFN1 structures reveal nucleotide-triggered dimerization critical for mitochondrial fusion. PMID:28114303
High-resolution cryo-EM structure of the proteasome in complex with ADP-AlFx. PMID:28106073
Homology modeling and molecular dynamics provide structural insights into tospovirus nucleoprotein. PMID:28105914
PICI: A web server with a multi-parametric algorithm for identifying interaction sites within protein complexes. PMID:28104965
Insights into ligand binding to a glutathione S-transferase from mango: Structure, thermodynamics and kinetics. PMID:28104507
Structure of the Z Ring-associated Protein, ZapD, Bound to the C-terminal Domain of the Tubulin-like Protein, FtsZ, Suggests Mechanism of Z Ring Stabilization through FtsZ Cross-linking. PMID:28100778
Molecular mechanism of the allosteric regulation of the αγ heterodimer of human NAD-dependent isocitrate dehydrogenase. PMID:28098230
A single MIU motif of MINDY-1 recognizes K48-linked polyubiquitin chains. PMID:28082312
Structural basis for nutrient acquisition by dominant members of the human gut microbiota. PMID:28077872
The role of interfacial lipids in stabilizing membrane protein oligomers. PMID:28077870
Structural and functional insights into asymmetric enzymatic dehydration of alkenols. PMID:28068311
X-ray crystal structure of the N-terminal region of Moloney murine leukemia virus integrase and its implications for viral DNA recognition. PMID:28066922
Homology-Based Modeling of Universal Stress Protein from Listeria innocua Up-Regulated under Acid Stress Conditions. PMID:28066336
Functional and structural studies on the Neisseria gonorrhoeae GmhA, the first enzyme in the glycero-manno-heptose biosynthesis pathways, demonstrate a critical role in lipooligosaccharide synthesis and gonococcal viability. PMID:28063198
Mutational landscape of antibody variable domains reveals a switch modulating the interdomain conformational dynamics and antigen binding. PMID:28057863
Oxidative Maturation and Structural Characterization of Prenylated FMN Binding by UbiD, a Decarboxylase Involved in Bacterial Ubiquinone Biosynthesis. PMID:28057757
Structure of the acetophenone carboxylase core complex: prototype of a new class of ATP-dependent carboxylases/hydrolases. PMID:28054554
Architecture and mechanism of the late endosomal Rab7-like Ypt7 guanine nucleotide exchange factor complex Mon1-Ccz1. PMID:28051187
Structure of a fungal form of aspartate-semialdehyde dehydrogenase from Aspergillus fumigatus. PMID:28045392
Crystal structure of a putrescine aminotransferase from Pseudomonas sp. strain AAC. PMID:28045391
X-ray crystal structure of a malonate-semialdehyde dehydrogenase from Pseudomonas sp. strain AAC. PMID:28045390
Crystal structure of the ATPase-C domain of the chromatin remodeller Fun30 from Saccharomyces cerevisiae. PMID:28045388
Disruption of cell adhesion by an antibody targeting the cell-adhesive intermediate (X-dimer) of human P-cadherin. PMID:28045038
Structural characterisation of the fatty acid biosynthesis enzyme FabF from the pathogen Listeria monocytogenes. PMID:28045020
Restriction endonuclease AgeI is a monomer which dimerizes to cleave DNA. PMID:28039325
Structural snapshots of Xer recombination reveal activation by synaptic complex remodeling and DNA bending. PMID:28009253
Biochemical and structural characterization of a novel halotolerant cellulase from soil metagenome. PMID:28008971
Structure and Function of the TIR Domain from the Grape NLR Protein RPV1. PMID:28008335
Structural basis of influenza virus fusion inhibition by the antiviral drug Arbidol. PMID:28003465
Toward Closing the Gap: Quantum Mechanical Calculations and Experimentally Measured Chemical Shifts of a Microcrystalline Lectin. PMID:28001418
Toxin inhibition in C. crescentus VapBC1 is mediated by a flexible pseudo-palindromic protein motif and modulated by DNA binding. PMID:27998932
Binding of Myomesin to Obscurin-Like-1 at the Muscle M-Band Provides a Strategy for Isoform-Specific Mechanical Protection. PMID:27989621
Short Carboxylic Acid-Carboxylate Hydrogen Bonds Can Have Fully Localized Protons. PMID:27989121
A Structural Investigation into Oct4 Regulation by Orphan Nuclear Receptors, Germ Cell Nuclear Factor (GCNF), and Liver Receptor Homolog-1 (LRH-1). PMID:27984042
Relief of autoinhibition by conformational switch explains enzyme activation by a catalytically dead paralog. PMID:27977001
Quantitative cross-linking/mass spectrometry reveals subtle protein conformational changes. PMID:27976756
Near-atomic-resolution cryo-EM analysis of the Salmonella T3S injectisome basal body. PMID:27974800
Vaccinia Virus Immunomodulator A46: A Lipid and Protein-Binding Scaffold for Sequestering Host TIR-Domain Proteins. PMID:27973613
Structure and Mechanism of Staphylococcus aureus TarS, the Wall Teichoic Acid β-glycosyltransferase Involved in Methicillin Resistance. PMID:27973583
Discovery and characterization of an F420-dependent glucose-6-phosphate dehydrogenase (Rh-FGD1) from Rhodococcus jostii RHA1. PMID:27966048
The Antiviral Mechanism of an Influenza A Virus Nucleoprotein-Specific Single-Domain Antibody Fragment. PMID:27965447
Structural and Biochemical Characterization of Cinnamoyl-CoA Reductases. PMID:27956488
Biophysical Studies of the Induced Dimerization of Human VEGF Receptor 1 Binding Domain by Divalent Metals Competing with VEGF-A. PMID:27942001
New additions to the ClusPro server motivated by CAPRI. PMID:27936493
Using the Amino Acid Network to Modulate the Hydrolytic Activity of β-Glycosidases. PMID:27936116
Cryo-electron Microscopy Study of the Genome Release of the Dicistrovirus Israeli Acute Bee Paralysis Virus. PMID:27928006
Structural basis of myelin-associated glycoprotein adhesion and signalling. PMID:27922006
Characterization and 1.57 Å resolution structure of the key fire blight phosphatase AmsI from Erwinia amylovora. PMID:27917839
Crystal structure of the toxin Msmeg_6760, the structural homolog of Mycobacterium tuberculosis Rv2035, a novel type II toxin involved in the hypoxic response. PMID:27917833
Structural analysis of the bright monomeric yellow-green fluorescent protein mNeonGreen obtained by directed evolution. PMID:27917830
The N14 anti-afamin antibody Fab: a rare VL1 CDR glycosylation, crystallographic re-sequencing, molecular plasticity and conservative versus enthusiastic modelling. PMID:27917827
Room temperature structure of human IgG4-Fc from crystals analysed in situ. PMID:27915153
ChaC2, an Enzyme for Slow Turnover of Cytosolic Glutathione. PMID:27913623
Structural insights into the LCIB protein family reveals a new group of β-carbonic anhydrases. PMID:27911826
Human antibody 3E1 targets the HA stem region of H1N1 and H5N6 influenza A viruses. PMID:27910950
Structural Insights into Streptococcal Competence Regulation by the Cell-to-Cell Communication System ComRS. PMID:27907189
Pheromone Recognition and Selectivity by ComR Proteins among Streptococcus Species. PMID:27907154
Malaria parasite CelTOS targets the inner leaflet of cell membranes for pore-dependent disruption. PMID:27906127
Discovery and structural characterisation of new fold type IV-transaminases exemplify the diversity of this enzyme fold. PMID:27905516
Biochemical and Structural Analysis of a Novel Esterase from Caulobacter crescentus related to Penicillin-Binding Protein (PBP). PMID:27905486
Structure of the RBM7-ZCCHC8 core of the NEXT complex reveals connections to splicing factors. PMID:27905398
The Production and Utilization of GDP-glucose in the Biosynthesis of Trehalose 6-Phosphate by Streptomyces venezuelae. PMID:27903647
Structures of human SRP72 complexes provide insights into SRP RNA remodeling and ribosome interaction. PMID:27899666
Structural Basis of the Oncogenic Interaction of Phosphatase PRL-1 with the Magnesium Transporter CNNM2. PMID:27899452
Inhibition of the GAS6/AXL pathway augments the efficacy of chemotherapies. PMID:27893463
Characterization of Class III Peroxidases from Switchgrass. PMID:27879392
Structure of protein O-mannose kinase reveals a unique active site architecture. PMID:27879205
Structural and Biochemical Studies Reveal a Putative FtsZ Recognition Site on the Z-ring Stabilizer ZapD. PMID:27871169
Ubiquitin-Dependent Modification of Skeletal Muscle by the Parasitic Nematode, Trichinella spiralis. PMID:27870901
Crystal Structure and Pyridoxal 5-Phosphate Binding Property of Lysine Decarboxylase from Selenomonas ruminantium. PMID:27861532
Membrane skeletal association and post-translational allosteric regulation of Toxoplasma gondii GAPDH1. PMID:27859784
Characterisation of a New Family of Carboxyl Esterases with an OsmC Domain. PMID:27851780
Introducing a Clustering Step in a Consensus Approach for the Scoring of Protein-Protein Docking Models. PMID:27846259
Structure of the cyanobactin oxidase ThcOx from Cyanothece sp. PCC 7425, the first structure to be solved at Diamond Light Source beamline I23 by means of S-SAD. PMID:27841750
Reader domain specificity and lysine demethylase-4 family function. PMID:27841353
The Structure of Treponema pallidum Tp0624 Reveals a Modular Assembly of Divergently Functionalized and Previously Uncharacterized Domains. PMID:27832149
BMI1 regulates PRC1 architecture and activity through homo- and hetero-oligomerization. PMID:27827373
Crystal structure of fuculose aldolase from the Antarctic psychrophilic yeast Glaciozyma antarctica PI12. PMID:27827354
Crystal structure of a phosphoribosyl anthranilate isomerase from the hyperthermophilic archaeon Thermococcus kodakaraensis. PMID:27827353
Inhibition of RAS function through targeting an allosteric regulatory site. PMID:27820802
Structural Insights into l-Tryptophan Dehydrogenase from a Photoautotrophic Cyanobacterium, Nostoc punctiforme. PMID:27815281
Structural Insights into the Drosophila melanogaster Retinol Dehydrogenase, a Member of the Short-Chain Dehydrogenase/Reductase Family. PMID:27809489
Metal-coupled folding as the driving force for the extreme stability of Rad50 zinc hook dimer assembly. PMID:27808280
Structural basis of the high thermal stability of the histone-like HU protein from the mollicute Spiroplasma melliferum KC3. PMID:27808161
Open and compressed conformations of Francisella tularensis ClpP. PMID:27802578
The IQGAP1 N-Terminus Forms Dimers, and the Dimer Interface Is Required for Binding F-Actin and Calcium-Bound Calmodulin. PMID:27798963
Structural analysis of X-linked retinoschisis mutations reveals distinct classes which differentially effect retinoschisin function. PMID:27798099
The CC domain structure from the wheat stem rust resistance protein Sr33 challenges paradigms for dimerization in plant NLR proteins. PMID:27791121
MET-activating Residues in the B-repeat of the Listeria monocytogenes Invasion Protein InlB. PMID:27789707
Structural determinants of adhesion by Protocadherin-19 and implications for its role in epilepsy. PMID:27787195
Crystal structures and inhibition of Trypanosoma brucei hypoxanthine-guanine phosphoribosyltransferase. PMID:27786284
Neisseria meningitidis factor H-binding protein bound to monoclonal antibody JAR5: implications for antibody synergy. PMID:27784765
Insight into the 3D structure and substrate specificity of previously uncharacterized GNAT superfamily acetyltransferases from pathogenic bacteria. PMID:27783928
γ-Protocadherin structural diversity and functional implications. PMID:27782885
Structural Analysis of the Catalytic Mechanism and Substrate Specificity of Anabaena Alkaline Invertase InvA Reveals a Novel Glucosidase. PMID:27777307
The macro domain as fusion tag for carrier-driven crystallization. PMID:27774698
Effects of a Mutation in the HSPE1 Gene Encoding the Mitochondrial Co-chaperonin HSP10 and Its Potential Association with a Neurological and Developmental Disorder. PMID:27774450
ClusPro-DC: Dimer Classification by the Cluspro Server for Protein-Protein Docking. PMID:27771482
A computational interactome and functional annotation for the human proteome. PMID:27770567
Direct and indirect mechanisms of KLK4 inhibition revealed by structure and dynamics. PMID:27767076
Identification of internalin-A-like virulent proteins in Leishmania donovani. PMID:27765050
Quantitative interaction mapping reveals an extended UBX domain in ASPL that disrupts functional p97 hexamers. PMID:27762274
Crystal structure of human aldehyde dehydrogenase 1A3 complexed with NAD+ and retinoic acid. PMID:27759097
Dirigent Protein Mode of Action Revealed by the Crystal Structure of AtDIR6. PMID:27756822
Oligomeric interface modulation causes misregulation of purine 5´-nucleotidase in relapsed leukemia. PMID:27756303
The Ebola Virus VP30-NP Interaction Is a Regulator of Viral RNA Synthesis. PMID:27755595
Deciphering metal ion preference and primary coordination sphere robustness of a designed zinc finger with high-resolution mass spectrometry. PMID:27750369
OmoMYC blunts promoter invasion by oncogenic MYC to inhibit gene expression characteristic of MYC-dependent tumors. PMID:27748763
Structure of the Catalytic Domain of the Class I Polyhydroxybutyrate Synthase from Cupriavidus necator. PMID:27742839
Extrinsic Functions of Lectin Domains in O-N-Acetylgalactosamine Glycan Biosynthesis. PMID:27738109
High-resolution crystal structure of the therapeutic antibody pembrolizumab bound to the human PD-1. PMID:27734966
Tetrameric structure of the restriction DNA glycosylase R.PabI in complex with nonspecific double-stranded DNA. PMID:27731370
Structure of the SLC4 transporter Bor1p in an inward-facing conformation. PMID:27717063
Crystal structure and DNA binding activity of a PadR family transcription regulator from hypervirulent Clostridium difficile R20291. PMID:27716049
Structural Basis of the Heterodimer Formation between Cell Shape-Determining Proteins Csd1 and Csd2 from Helicobacter pylori. PMID:27711177
Empirical power laws for the radii of gyration of protein oligomers. PMID:27710933
X-ray structure of the human α4β2 nicotinic receptor. PMID:27698419
Enzymatic hydrolysis by transition-metal-dependent nucleophilic aromatic substitution. PMID:27694799
Wnt Signalosome Assembly by DEP Domain Swapping of Dishevelled. PMID:27692984
Structural Characterization of the Avidin Interactions with Fluorescent Pyrene-Conjugates: 1-Biotinylpyrene and 1-Desthiobiotinylpyrene. PMID:27689976
'AND' logic gates at work: Crystal structure of Rad53 bound to Dbf4 and Cdc7. PMID:27681475
Structures of Proline Utilization A (PutA) Reveal the Fold and Functions of the Aldehyde Dehydrogenase Superfamily Domain of Unknown Function. PMID:27679491
Common Evolutionary Origin of Procapsid Proteases, Phage Tail Tubes, and Tubes of Bacterial Type VI Secretion Systems. PMID:27667692
Structural and histone binding ability characterization of the ARB2 domain of a histone deacetylase Hda1 from Saccharomyces cerevisiae. PMID:27665728
Molecular insights into substrate recognition and catalytic mechanism of the chaperone and FKBP peptidyl-prolyl isomerase SlyD. PMID:27664121
The Panitumumab EGFR Complex Reveals a Binding Mechanism That Overcomes Cetuximab Induced Resistance. PMID:27658254
Crystal Structure of the Escherichia coli Fic Toxin-Like Protein in Complex with Its Cognate Antitoxin. PMID:27657533
Structural insight into the role of the Ton complex in energy transduction. PMID:27654919
A conserved two-step binding for the UAF1 regulator to the USP12 deubiquitinating enzyme. PMID:27650958
Molecular basis of sidekick-mediated cell-cell adhesion and specificity. PMID:27644106
Molecular basis of cobalamin-dependent RNA modification. PMID:27638883
Structure of Arabidopsis thaliana FUT1 Reveals a Variant of the GT-B Class Fold and Provides Insight into Xyloglucan Fucosylation. PMID:27637560
Computationally designed peptides for self-assembly of nanostructured lattices. PMID:27626071
The centrosomal deubiquitylase USP21 regulates Gli1 transcriptional activity and stability. PMID:27621083
Natively glycosylated HIV-1 Env structure reveals new mode for antibody recognition of the CD4-binding site. PMID:27617431
Structures of type IV pilins from Thermus thermophilus demonstrate similarities with type II secretion system pseudopilins. PMID:27612581
Isolation, Co-Crystallization and Structure-Based Characterization of Anabaenopeptins as Highly Potent Inhibitors of Activated Thrombin Activatable Fibrinolysis Inhibitor (TAFIa). PMID:27604544
Structure of an Inward Proton-Transporting Anabaena Sensory Rhodopsin Mutant: Mechanistic Insights. PMID:27602724
The Anti-sigma Factor RsiV Is a Bacterial Receptor for Lysozyme: Co-crystal Structure Determination and Demonstration That Binding of Lysozyme to RsiV Is Required for σV Activation. PMID:27602573
WD40 domain of Apc1 is critical for the coactivator-induced allosteric transition that stimulates APC/C catalytic activity. PMID:27601667
Structural analysis of point mutations at the Vaccinia virus A20/D4 interface. PMID:27599859
Crystal structure of Plasmodium falciparum proplasmepsin IV: the plasticity of proplasmepsins. PMID:27599854
Structures of a Nonribosomal Peptide Synthetase Module Bound to MbtH-like Proteins Support a Highly Dynamic Domain Architecture. PMID:27597544
Structure of human Aichi virus and implications for receptor binding. PMID:27595320
The Sampling of Conformational Dynamics in Ambient-Temperature Crystal Structures of Arginine Kinase. PMID:27594681
Specific Recognition of a Single-Stranded RNA Sequence by a Synthetic Antibody Fragment. PMID:27593161
Structural insights into the IgE mediated responses induced by the allergens Hev b 8 and Zea m 12 in their dimeric forms. PMID:27586352
The Structure of the Periplasmic Sensor Domain of the Histidine Kinase CusS Shows Unusual Metal Ion Coordination at the Dimeric Interface. PMID:27583660
The BR domain of PsrP interacts with extracellular DNA to promote bacterial aggregation; structural insights into pneumococcal biofilm formation. PMID:27582320
Circumventing the stability-function trade-off in an engineered FN3 domain. PMID:27578887
Interaction mode between catalytic and regulatory subunits in glucosidase II involved in ER glycoprotein quality control. PMID:27576940
Structural and Functional Studies of Pavine N-Methyltransferase from Thalictrum flavum Reveal Novel Insights into Substrate Recognition and Catalytic Mechanism. PMID:27573242
Structure of an acetylating aldehyde dehydrogenase from the thermophilic ethanologen Geobacillus thermoglucosidasius. PMID:27571338
Minimally Mutated HIV-1 Broadly Neutralizing Antibodies to Guide Reductionist Vaccine Design. PMID:27560183
Crystal Structures of SgcE6 and SgcC, the Two-Component Monooxygenase That Catalyzes Hydroxylation of a Carrier Protein-Tethered Substrate during the Biosynthesis of the Enediyne Antitumor Antibiotic C-1027 in Streptomyces globisporus. PMID:27560143
The Structure of the Antibiotic Deactivating, N-hydroxylating Rifampicin Monooxygenase. PMID:27557658
Structures of the activator of K. pneumonia biofilm formation, MrkH, indicates PilZ domains involved in c-di-GMP and DNA binding. PMID:27551088
Biocatalytic Asymmetric Alkene Reduction: Crystal Structure and Characterization of a Double Bond Reductase from Nicotiana tabacum. PMID:27547488
Structural Basis for Interactions Between Contactin Family Members and Protein-tyrosine Phosphatase Receptor Type G in Neural Tissues. PMID:27539848
GalaxyRefineComplex: Refinement of protein-protein complex model structures driven by interface repacking. PMID:27535582
Near-Atomic Resolution Structure of a Highly Neutralizing Fab Bound to Canine Parvovirus. PMID:27535057
Two distinct mechanisms of transcriptional regulation by the redox sensor YodB. PMID:27531959
The second messenger c-di-AMP inhibits the osmolyte uptake system OpuC in Staphylococcus aureus. PMID:27531650
Mouse MORC3 is a GHKL ATPase that localizes to H3K4me3 marked chromatin. PMID:27528681
Genomic and expression analyses of Tursiops truncatus T cell receptor gamma (TRG) and alpha/delta (TRA/TRD) loci reveal a similar basic public γδ repertoire in dolphin and human. PMID:27528257
Binding site elucidation and structure guided design of macrocyclic IL-17A antagonists. PMID:27527709
Architecture of the Human Mitochondrial Iron-Sulfur Cluster Assembly Machinery. PMID:27519411
Structural basis for cytokinin production by LOG from Corynebacterium glutamicum. PMID:27507425
Divergence in Ubiquitin Interaction and Catalysis among the Ubiquitin-Specific Protease Family Deubiquitinating Enzymes. PMID:27501351
Tankyrase Requires SAM Domain-Dependent Polymerization to Support Wnt-β-Catenin Signaling. PMID:27494558
Crystal structure of a human neuronal nAChR extracellular domain in pentameric assembly: Ligand-bound α2 homopentamer. PMID:27493220
The dopamine D2 receptor dimer and its interaction with homobivalent antagonists: homology modeling, docking and molecular dynamics. PMID:27491852
Crystal structure of AibC, a reductase involved in alternative de novo isovaleryl coenzyme A biosynthesis in Myxococcus xanthus. PMID:27487931
2.4 Å resolution crystal structure of human TRAP1NM, the Hsp90 paralog in the mitochondrial matrix. PMID:27487821
Mechanism of arginine sensing by CASTOR1 upstream of mTORC1. PMID:27487210
How Quorum Sensing Connects Sporulation to Necrotrophism in Bacillus thuringiensis. PMID:27483473
Crystal structures of APOBEC3G N-domain alone and its complex with DNA. PMID:27480941
Antiparallel protocadherin homodimers use distinct affinity- and specificity-mediating regions in cadherin repeats 1-4. PMID:27472898
Validation of a multi-omics strategy for prioritizing personalized candidate driver genes. PMID:27469031
Context matters: The importance of dimerization-induced conformation of the LukGH leukocidin of Staphylococcus aureus for the generation of neutralizing antibodies. PMID:27467113
Dynamic phosphorylation of RelA on Ser42 and Ser45 in response to TNFα stimulation regulates DNA binding and transcription. PMID:27466442
Structure of the Single-lobe Myosin Light Chain C in Complex with the Light Chain-binding Domains of Myosin-1C Provides Insights into Divergent IQ Motif Recognition. PMID:27466369
The Crystal Structures of the N-terminal Photosensory Core Module of Agrobacterium Phytochrome Agp1 as Parallel and Anti-parallel Dimers. PMID:27466363
Accurate design of megadalton-scale two-component icosahedral protein complexes. PMID:27463675
Structure-Based Design of Head-Only Fusion Glycoprotein Immunogens for Respiratory Syncytial Virus. PMID:27463224
Structural basis for exploring the allosteric inhibition of human kidney type glutaminase. PMID:27462863
Structural basis for Sfm1 functioning as a protein arginine methyltransferase. PMID:27462434
The Structure and Catalytic Mechanism of Sorghum bicolor Caffeoyl-CoA O-Methyltransferase. PMID:27457122
A Structural, Functional, and Computational Analysis of BshA, the First Enzyme in the Bacillithiol Biosynthesis Pathway. PMID:27454321
Revisiting the mechanism of coagulation factor XIII activation and regulation from a structure/functional perspective. PMID:27453290
Structural and Functional Studies of H. seropedicae RecA Protein - Insights into the Polymerization of RecA Protein as Nucleoprotein Filament. PMID:27447485
The Crystal Structure of the C-Terminal Domain of the Salmonella enterica PduO Protein: An Old Fold with a New Heme-Binding Mode. PMID:27446048
Functional Diversity of Cytotoxic tRNase/Immunity Protein Complexes from Burkholderia pseudomallei. PMID:27445337
Structural basis of Smoothened regulation by its extracellular domains. PMID:27437577
Crystal Structure of the N-Terminal RNA Recognition Motif of mRNA Decay Regulator AUF1. PMID:27437398
Sensing and signaling of oxidative stress in chloroplasts by inactivation of the SAL1 phosphoadenosine phosphatase. PMID:27432987
Mass spectrometry locates local and allosteric conformational changes that occur on cofactor binding. PMID:27418477
Identification of an ATP-controlled allosteric switch that controls actin filament nucleation by Arp2/3 complex. PMID:27417392
Structural Characterization of H1N1 Nucleoprotein-Nucleozin Binding Sites. PMID:27404920
Diverse architectural properties of Sso10a proteins: Evidence for a role in chromatin compaction and organization. PMID:27403582
Multi-OMICs and Genome Editing Perspectives on Liver Cancer Signaling Networks. PMID:27403431
Structural and biophysical analysis of nuclease protein antibiotics. PMID:27402794
Structural mapping of Kelch13 mutations associated with artemisinin resistance in malaria. PMID:27400688
Development of a protein-ligand-binding site prediction method based on interaction energy and sequence conservation. PMID:27400687
Structure of the magnetosome-associated actin-like MamK filament at subnanometer resolution. PMID:27391173
Cryoannealing-induced space-group transition of crystals of the carbonic anhydrase psCA3. PMID:27380376
Crystal structure of truncated aspartate transcarbamoylase from Plasmodium falciparum. PMID:27380369
Structural and functional studies of the glycoside hydrolase family 3 β-glucosidase Cel3A from the moderately thermophilic fungus Rasamsonia emersonii. PMID:27377383
Bile salt receptor complex activates a pathogenic type III secretion system. PMID:27377244
Identification, Characterization, and X-ray Crystallographic Analysis of a Novel Type of Mannose-Specific Lectin CGL1 from the Pacific Oyster Crassostrea gigas. PMID:27377186
Rv2074 is a novel F420 H2 -dependent biliverdin reductase in Mycobacterium tuberculosis. PMID:27364382
Molecular dynamics simulations and structure-based network analysis reveal structural and functional aspects of G-protein coupled receptor dimer interactions. PMID:27349423
Structure of a Cytoplasmic 11-Subunit RNA Exosome Complex. PMID:27345150
HU histone-like DNA-binding protein from Thermus thermophilus: structural and evolutionary analyses. PMID:27342116
Structural basis of potent Zika-dengue virus antibody cross-neutralization. PMID:27338953
AraPPISite: a database of fine-grained protein-protein interaction site annotations for Arabidopsis thaliana. PMID:27338257
Structural and functional analysis of the solute-binding protein UspC from Mycobacterium tuberculosis that is specific for amino sugars. PMID:27335320
Crystal structure of raptor adenovirus 1 fibre head and role of the beta-hairpin in siadenovirus fibre head domains. PMID:27334597
Structure of a phleboviral envelope glycoprotein reveals a consolidated model of membrane fusion. PMID:27325770
Structural insights of ZIP4 extracellular domain critical for optimal zinc transport. PMID:27321477
Crystal structure of MytiLec, a galactose-binding lectin from the mussel Mytilus galloprovincialis with cytotoxicity against certain cancer cell types. PMID:27321048
Structural Basis for the Specific Recognition of RhoA by the Dual GTPase-activating Protein ARAP3. PMID:27311713
Structural basis of thiol-based regulation of formaldehyde detoxification in H. influenzae by a MerR regulator with no sensor region. PMID:27307602
Crystal structure of the TK2203 protein from Thermococcus kodakarensis, a putative extradiol dioxygenase. PMID:27303894
Biochemical and structural characterization of Klebsiella pneumoniae oxamate amidohydrolase in the uric acid degradation pathway. PMID:27303801
Cross-class metallo-β-lactamase inhibition by bisthiazolidines reveals multiple binding modes. PMID:27303030
Immunosuppressive Yersinia Effector YopM Binds DEAD Box Helicase DDX3 to Control Ribosomal S6 Kinase in the Nucleus of Host Cells. PMID:27300509
Deciphering Dimerization Modes of PAS Domains: Computational and Experimental Analyses of the AhR:ARNT Complex Reveal New Insights Into the Mechanisms of AhR Transformation. PMID:27295348
Structural basis for the antagonistic roles of RNP-8 and GLD-3 in GLD-2 poly(A)-polymerase activity. PMID:27288313
Structure of the host-recognition device of Staphylococcus aureus phage ϕ11. PMID:27282779
The C-Terminal Arm of the Human Papillomavirus Major Capsid Protein Is Immunogenic and Involved in Virus-Host Interaction. PMID:27276427
Structural and Functional Characterization of a Novel Family of Cyclophilins, the AquaCyps. PMID:27276069
Bending-Twisting Motions and Main Interactions in Nucleoplasmin Nuclear Import. PMID:27258022
Structural and Functional Characterization of Aerobactin Synthetase IucA from a Hypervirulent Pathotype of Klebsiella pneumoniae. PMID:27253399
1,2-Propanediol Dehydration in Roseburia inulinivorans: STRUCTURAL BASIS FOR SUBSTRATE AND ENANTIOMER SELECTIVITY. PMID:27252380
Crystal structure of human S100A8 in complex with zinc and calcium. PMID:27251136
Structural and mutational analysis of the interaction between the Middle-East respiratory syndrome coronavirus (MERS-CoV) papain-like protease and human ubiquitin. PMID:27245450
Crystal Structure of Hyp-1, a Hypericum perforatum PR-10 Protein, in Complex with Melatonin. PMID:27242869
Structural, Functional, and Immunological Characterization of Profilin Panallergens Amb a 8, Art v 4, and Bet v 2. PMID:27231348
Crystal Structure of the FERM-SH2 Module of Human Jak2. PMID:27227461
Structural Insights into the Polyphyletic Origins of Glycyl tRNA Synthetases. PMID:27226617
Abundance and Temperature Dependency of Protein-Protein Interaction Revealed by Interface Structure Analysis and Stability Evolution. PMID:27220911
Cholesterol Corrects Altered Conformation of MHC-II Protein in Leishmania donovani Infected Macrophages: Implication in Therapy. PMID:27214205
Structure of the Dictyostelium Myosin-II Heavy Chain Kinase A (MHCK-A) α-kinase domain apoenzyme reveals a novel autoinhibited conformation. PMID:27211275
Structural diversity in a human antibody germline library. PMID:27210805
Bacterial β-Kdo glycosyltransferases represent a new glycosyltransferase family (GT99). PMID:27199480
Broadly neutralizing epitopes in the Plasmodium vivax vaccine candidate Duffy Binding Protein. PMID:27194724
A rationally engineered yeast pyruvyltransferase Pvg1p introduces sialylation-like properties in neo-human-type complex oligosaccharide. PMID:27194449
Structural basis of omalizumab therapy and omalizumab-mediated IgE exchange. PMID:27194387
Structure of the T4 baseplate and its function in triggering sheath contraction. PMID:27193680
Campylobacter jejuni adenosine triphosphate phosphoribosyltransferase is an active hexamer that is allosterically controlled by the twisting of a regulatory tail. PMID:27191057
Structural dynamics of a methionine γ-lyase for calicheamicin biosynthesis: Rotation of the conserved tyrosine stacking with pyridoxal phosphate. PMID:27191010
Structure-based Epitope Mapping of Mycobacterium tuberculosis Secretary Antigen MTC28. PMID:27189947
Biological function derived from predicted structures in CASP11. PMID:27181425
Two common structural motifs for TCR recognition by staphylococcal enterotoxins. PMID:27180909
Identification of a Functionally Relevant Adeno-Associated Virus Rep68 Oligomeric Interface. PMID:27170758
ConSurf 2016: an improved methodology to estimate and visualize evolutionary conservation in macromolecules. PMID:27166375
Transcription of lncRNA prt, clustered prt RNA sites for Mmi1 binding, and RNA polymerase II CTD phospho-sites govern the repression of pho1 gene expression under phosphate-replete conditions in fission yeast. PMID:27165520
Structural and Functional Characterization of the LPS Transporter LptDE from Gram-Negative Pathogens. PMID:27161977
Molecular basis of PRC1 targeting to Polycomb response elements by PhoRC. PMID:27151979
A small protein inhibits proliferating cell nuclear antigen by breaking the DNA clamp. PMID:27141962
RRM domain of human RBM7: purification, crystallization and structure determination. PMID:27139832
Structural and functional insights into the stationary-phase survival protein SurE, an important virulence factor of Brucella abortus. PMID:27139831
Crystal structure of bile salt hydrolase from Lactobacillus salivarius. PMID:27139829
Crystal structure of ketopantoate reductase from Thermococcus kodakarensis complexed with NADP(.). PMID:27139828
Structural analysis of a phosphonate hydroxylase with an access tunnel at the back of the active site. PMID:27139827
Crystal structures of a group II intron maturase reveal a missing link in spliceosome evolution. PMID:27136328
Death-Associated Protein Kinase Activity Is Regulated by Coupled Calcium/Calmodulin Binding to Two Distinct Sites. PMID:27133022
EssC: domain structures inform on the elusive translocation channel in the Type VII secretion system. PMID:27130157
Biocatalytic Properties and Structural Analysis of Eugenol Oxidase from Rhodococcus jostii RHA1: A Versatile Oxidative Biocatalyst. PMID:27123962
Prediction of homoprotein and heteroprotein complexes by protein docking and template-based modeling: A CASP-CAPRI experiment. PMID:27122118
Divergent non-heme iron enzymes in the nogalamycin biosynthetic pathway. PMID:27114534
A β-Alanine Catabolism Pathway Containing a Highly Promiscuous ω-Transaminase in the 12-Aminododecanate-Degrading Pseudomonas sp. Strain AAC. PMID:27107110
Molecular Basis of Ligand-Dependent Regulation of NadR, the Transcriptional Repressor of Meningococcal Virulence Factor NadA. PMID:27105075
Crystal Structures and Binding Dynamics of Odorant-Binding Protein 3 from two aphid species Megoura viciae and Nasonovia ribisnigri. PMID:27102935
Structural basis for the specific inhibition of glycoprotein Ibα shedding by an inhibitory antibody. PMID:27102061
Crystal structures of the transpeptidase domain of the Mycobacterium tuberculosis penicillin-binding protein PonA1 reveal potential mechanisms of antibiotic resistance. PMID:27101811
Noncanonical DNA-binding mode of repressor and its disassembly by antirepressor. PMID:27099293
Computational study of pH-dependent oligomerization and ligand binding in Alt a 1, a highly allergenic protein with a unique fold. PMID:27090909
Fasciola hepatica calcium-binding protein FhCaBP2: structure of the dynein light chain-like domain. PMID:27083189
A Novel Fic (Filamentation Induced by cAMP) Protein from Clostridium difficile Reveals an Inhibitory Motif-independent Adenylylation/AMPylation Mechanism. PMID:27076635
Structural insight into the cooperation of chloroplast chaperonin subunits. PMID:27072913
Made to measure - keeping Rho kinase at a distance. PMID:27070834
Burkholderia glumae ToxA Is a Dual-Specificity Methyltransferase That Catalyzes the Last Two Steps of Toxoflavin Biosynthesis. PMID:27070241
Crystal structure analysis of C-phycoerythrin from marine cyanobacterium Phormidium sp. A09DM. PMID:27068646
Crystal structure of a putative exo-β-1,3-galactanase from Bifidobacterium bifidum S17. PMID:27050262
T-to-R switch of muscle fructose-1,6-bisphosphatase involves fundamental changes of secondary and quaternary structure. PMID:27050133
The 2.2-Angstrom resolution crystal structure of the carboxy-terminal region of ataxin-3. PMID:27047745
Facilitating model reconstruction for single-particle scattering using small-angle X-ray scattering methods. PMID:27047310
Structure-Based Analysis Reveals Cancer Missense Mutations Target Protein Interaction Interfaces. PMID:27043210
Paring Down HIV Env: Design and Crystal Structure of a Stabilized Inner Domain of HIV-1 gp120 Displaying a Major ADCC Target of the A32 Region. PMID:27041594
Divergent Evolution of Nuclear Localization Signal Sequences in Herpesvirus Terminase Subunits. PMID:27033706
Structural insight for substrate tolerance to 2-deoxyribose-5-phosphate aldolase from the pathogen Streptococcus suis. PMID:27033207
Structure of smAKAP and its regulation by PKA-mediated phosphorylation. PMID:27028580
Sleeping Beauty transposase structure allows rational design of hyperactive variants for genetic engineering. PMID:27025571
Substrate complexes of human dipeptidyl peptidase III reveal the mechanism of enzyme inhibition. PMID:27025154
CoDNaS 2.0: a comprehensive database of protein conformational diversity in the native state. PMID:27022160
Structure-Function Relationships in l-Amino Acid Deaminase, a Flavoprotein Belonging to a Novel Class of Biotechnologically Relevant Enzymes. PMID:27022028
PilN Binding Modulates the Structure and Binding Partners of the Pseudomonas aeruginosa Type IVa Pilus Protein PilM. PMID:27022027
Structural basis for therapeutic inhibition of complement C5. PMID:27018802
Crystal Structure of Human Myotubularin-Related Protein 1 Provides Insight into the Structural Basis of Substrate Specificity. PMID:27018598
Biochemical characterization and structural analysis of a new cold-active and salt-tolerant esterase from the marine bacterium Thalassospira sp. PMID:27016194
HIV-1 broadly neutralizing antibody precursor B cells revealed by germline-targeting immunogen. PMID:27013733
Regulators of complement activity mediate inhibitory mechanisms through a common C3b-binding mode. PMID:27013439
The first crystal structure of human RNase 6 reveals a novel substrate-binding and cleavage site arrangement. PMID:27013146
Mass Spectrometry Reveals Protein Kinase CK2 High-Order Oligomerization via the Circular and Linear Assembly. PMID:26999075
Structural basis for germline antibody recognition of HIV-1 immunogens. PMID:26997349
Structural Studies of Medicago truncatula Histidinol Phosphate Phosphatase from Inositol Monophosphatase Superfamily Reveal Details of Penultimate Step of Histidine Biosynthesis in Plants. PMID:26994138
Haem-dependent dimerization of PGRMC1/Sigma-2 receptor facilitates cancer proliferation and chemoresistance. PMID:26988023
Biochemistry and Crystal Structure of Ectoine Synthase: A Metal-Containing Member of the Cupin Superfamily. PMID:26986827
Aurone synthase is a catechol oxidase with hydroxylase activity and provides insights into the mechanism of plant polyphenol oxidases. PMID:26976571
Mycocerosic acid synthase exemplifies the architecture of reducing polyketide synthases. PMID:26976449
Structural basis of H2A.Z recognition by SRCAP chromatin-remodeling subunit YL1. PMID:26974124
Systems biology of the structural proteome. PMID:26969117
Construction of a hybrid β-hexosaminidase subunit capable of forming stable homodimers that hydrolyze GM2 ganglioside in vivo. PMID:26966698
Genome and network visualization facilitates the analyses of the effects of drugs and mutations on protein-protein and drug-protein networks. PMID:26961139
Crystal Structure and Biochemical Characterization of a Mycobacterium smegmatis AAA-Type Nucleoside Triphosphatase Phosphohydrolase (Msm0858). PMID:26953339
Structural basis of allosteric and synergistic activation of AMPK by furan-2-phosphonic derivative C2 binding. PMID:26952388
The structure and dynamics of secretory component and its interactions with polymeric immunoglobulins. PMID:26943617
Architecture of the Yeast Mitochondrial Iron-Sulfur Cluster Assembly Machinery: THE SUB-COMPLEX FORMED BY THE IRON DONOR, Yfh1 PROTEIN, AND THE SCAFFOLD, Isu1 PROTEIN. PMID:26941001
Perchlorate Reductase Is Distinguished by Active Site Aromatic Gate Residues. PMID:26940877
Structure-Based Statistical Mechanical Model Accounts for the Causality and Energetics of Allosteric Communication. PMID:26939022
Paulistine--The Functional Duality of a Wasp Venom Peptide Toxin. PMID:26938560
Crystal structure of a hypothetical protein, TTHA0829 from Thermus thermophilus HB8, composed of cystathionine-β-synthase (CBS) and aspartate-kinase chorismate-mutase tyrA (ACT) domains. PMID:26936147
The immunity-related GTPase Irga6 dimerizes in a parallel head-to-head fashion. PMID:26934976
Mitochondrial Hsp90 is a ligand-activated molecular chaperone coupling ATP binding to dimer closure through a coiled-coil intermediate. PMID:26929380
Structures of EccB1 and EccD1 from the core complex of the mycobacterial ESX-1 type VII secretion system. PMID:26922638
Reply to "The Broadly Neutralizing, Anti-HIV Antibody 4E10: an Open and Shut Case?". PMID:26921373
Dimerization of Bacterial Diaminopimelate Decarboxylase Is Essential for Catalysis. PMID:26921318
Energetic Coupling between Ligand Binding and Dimerization in Escherichia coli Phosphoglycerate Mutase. PMID:26919584
Structural investigation of the thymidine phosphorylase from Salmonella typhimurium in the unliganded state and its complexes with thymidine and uridine. PMID:26919527
Crystal structure of FhuD at 1.6 Å resolution: a ferrichrome-binding protein from the animal and human pathogen Staphylococcus pseudintermedius. PMID:26919525
Crystal structure of maize serine racemase with pyridoxal 5'-phosphate. PMID:26919519
Crystal structure of human GDF11. PMID:26919518
The extended structure of the periplasmic region of CdsD, a structural protein of the type III secretion system of Chlamydia trachomatis. PMID:26914207
Structural and kinetic studies on RosA, the enzyme catalysing the methylation of 8-demethyl-8-amino-d-riboflavin to the antibiotic roseoflavin. PMID:26913589
Mapping Antigenic Epitopes on the Human Bocavirus Capsid. PMID:26912619
Molecular association of glucose-6-phosphate isomerase and pyruvate kinase M2 with glyceraldehyde-3-phosphate dehydrogenase in cancer cells. PMID:26911935
Structures of Two Melanoma-Associated Antigens Suggest Allosteric Regulation of Effector Binding. PMID:26910052
Structural basis of lenalidomide-induced CK1α degradation by the CRL4(CRBN) ubiquitin ligase. PMID:26909574
Structural basis of specific inhibition of tissue-type plasminogen activator by plasminogen activators inhibitor-1. PMID:26909366
Functional Evolution in Orthologous Cell-encoded RNA-dependent RNA Polymerases. PMID:26907693
Crystal Structure of Alcohol Oxidase from Pichia pastoris. PMID:26905908
Structure and Interactions of a Dimeric Variant of sHIP, a Novel Virulence Determinant of Streptococcus pyogenes. PMID:26903974
Molecular Insights into Toluene Sensing in the TodS/TodT Signal Transduction System. PMID:26903514
Insight into Structure-Function Relationships and Inhibition of the Fatty Acyl-AMP Ligase (FadD32) Orthologs from Mycobacteria. PMID:26900152
Insight into Coenzyme A cofactor binding and the mechanism of acyl-transfer in an acylating aldehyde dehydrogenase from Clostridium phytofermentans. PMID:26899032
Dengue Virus Nonstructural Protein 5 (NS5) Assembles into a Dimer with a Unique Methyltransferase and Polymerase Interface. PMID:26895240
Three-dimensional structures of two heavily N-glycosylated Aspergillus sp. family GH3 β-D-glucosidases. PMID:26894673
Molecular architecture of the nucleoprotein C-terminal domain from the Ebola and Marburg viruses. PMID:26894534
Binding interface change and cryptic variation in the evolution of protein-protein interactions. PMID:26892785
Functional and Structural Analysis of a β-Glucosidase Involved in β-1,2-Glucan Metabolism in Listeria innocua. PMID:26886583
Mechanism of a cytosolic O-glycosyltransferase essential for the synthesis of a bacterial adhesion protein. PMID:26884191
Conformational plasticity of RepB, the replication initiator protein of promiscuous streptococcal plasmid pMV158. PMID:26875695
First structure of archaeal branched-chain amino acid aminotransferase from Thermoproteus uzoniensis specific for L-amino acids and R-amines. PMID:26872794
Structural Insights into the Tetrameric State of Aspartate-β-semialdehyde Dehydrogenases from Fungal Species. PMID:26869335
Structural and Kinetic Characterization of the 4-Carboxy-2-hydroxymuconate Hydratase from the Gallate and Protocatechuate 4,5-Cleavage Pathways of Pseudomonas putida KT2440. PMID:26867578
A complex water network contributes to high-affinity binding in an antibody-antigen interface. PMID:26862587
Elongation of the Poly-γ-glutamate Tail of F420 Requires Both Domains of the F420:γ-Glutamyl Ligase (FbiB) of Mycobacterium tuberculosis. PMID:26861878
How the oxygen tolerance of a [NiFe]-hydrogenase depends on quaternary structure. PMID:26861789
A glutamate/aspartate switch controls product specificity in a protein arginine methyltransferase. PMID:26858449
The Structure of the Transcriptional Repressor KstR in Complex with CoA Thioester Cholesterol Metabolites Sheds Light on the Regulation of Cholesterol Catabolism in Mycobacterium tuberculosis. PMID:26858250
Cryo-electron microscopy structure of a coronavirus spike glycoprotein trimer. PMID:26855426
Structural characterization of GASDALIE Fc bound to the activating Fc receptor FcγRIIIa. PMID:26850169
On Nature's Strategy for Assigning Genetic Code Multiplicity. PMID:26849571
Structural Insights into Mycobacterium tuberculosis Rv2671 Protein as a Dihydrofolate Reductase Functional Analogue Contributing to para-Aminosalicylic Acid Resistance. PMID:26848874
Hepatitis B Virus Capsids Have Diverse Structural Responses to Small-Molecule Ligands Bound to the Heteroaryldihydropyrimidine Pocket. PMID:26842475
Crystal structure of the flavoenzyme PA4991 from Pseudomonas aeruginosa. PMID:26841760
Arm-in-Arm Response Regulator Dimers Promote Intermolecular Signal Transduction. PMID:26833410
L-Hydroxyproline and d-Proline Catabolism in Sinorhizobium meliloti. PMID:26833407
Structure-based analysis of the molecular interactions between acyltransferase and acyl carrier protein in vicenistatin biosynthesis. PMID:26831085
Dlx5 Homeodomain:DNA Complex: Structure, Binding and Effect of Mutations Related to Split Hand and Foot Malformation Syndrome. PMID:26829219
The Functional Unit of Neisseria meningitidis 3-Deoxy-ᴅ-Arabino-Heptulosonate 7-Phosphate Synthase Is Dimeric. PMID:26828675
Identification of LACTB2, a metallo-β-lactamase protein, as a human mitochondrial endoribonuclease. PMID:26826708
The Atomic Structure of the Phage Tuc2009 Baseplate Tripod Suggests that Host Recognition Involves Two Different Carbohydrate Binding Modules. PMID:26814179
Insights into Complex Oxidation during BE-7585A Biosynthesis: Structural Determination and Analysis of the Polyketide Monooxygenase BexE. PMID:26813028
A structured interdomain linker directs self-polymerization of human uromodulin. PMID:26811476
PqsBC, a Condensing Enzyme in the Biosynthesis of the Pseudomonas aeruginosa Quinolone Signal: CRYSTAL STRUCTURE, INHIBITION, AND REACTION MECHANISM. PMID:26811339
Loop-to-helix transition in the structure of multidrug regulator AcrR at the entrance of the drug-binding cavity. PMID:26796657
Deciphering the Substrate Specificity of SbnA, the Enzyme Catalyzing the First Step in Staphyloferrin B Biosynthesis. PMID:26794841
Structure of NDP-forming Acetyl-CoA synthetase ACD1 reveals a large rearrangement for phosphoryl transfer. PMID:26787904
PGL germ granule assembly protein is a base-specific, single-stranded RNase. PMID:26787882
Structural basis and function of XRN2 binding by XTB domains. PMID:26779609
Structure-based approach to the identification of a novel group of selective glucosamine analogue inhibitors of Trypanosoma cruzi glucokinase. PMID:26778112
Structural and functional insights into the fly microRNA biogenesis factor Loquacious. PMID:26769856
The Quaternary Structure of a Glycoside Hydrolase Dictates Specificity toward β-Glucans. PMID:26755730
Structures of Xenopus Embryonic Epidermal Lectin Reveal a Conserved Mechanism of Microbial Glycan Recognition. PMID:26755729
Structure of the Regulator of G Protein Signaling 8 (RGS8)-Gαq Complex: MOLECULAR BASIS FOR Gα SELECTIVITY. PMID:26755720
Blue light-induced LOV domain dimerization enhances the affinity of Aureochrome 1a for its target DNA sequence. PMID:26754770
Crystal structure of HINT from Helicobacter pylori. PMID:26750483
Expression, crystallization and structure elucidation of γ-terpinene synthase from Thymus vulgaris. PMID:26750479
Cloning, expression, purification, crystallization and X-ray diffraction analysis of dihydrodipicolinate synthase from the human pathogenic bacterium Bartonella henselae strain Houston-1 at 2.1 Å resolution. PMID:26750477
The Structure of a BamA-BamD Fusion Illuminates the Architecture of the β-Barrel Assembly Machine Core. PMID:26749448
Refining the Structural Model of a Heterohexameric Protein Complex: Surface Induced Dissociation and Ion Mobility Provide Key Connectivity and Topology Information. PMID:26744735
The structure of the β-barrel assembly machinery complex. PMID:26744406
Discovery and Characterization of a Thermostable and Highly Halotolerant GH5 Cellulase from an Icelandic Hot Spring Isolate. PMID:26741138
Antibody Response to Hypervariable Region 1 Interferes with Broadly Neutralizing Antibodies to Hepatitis C Virus. PMID:26739044
Structural Based Analyses of the JC Virus T-Antigen F258L Mutant Provides Evidence for DNA Dependent Conformational Changes in the C-Termini of Polyomavirus Origin Binding Domains. PMID:26735515
Structure of the polyisoprenyl-phosphate glycosyltransferase GtrB and insights into the mechanism of catalysis. PMID:26729507
Myristoylation drives dimerization of matrix protein from mouse mammary tumor virus. PMID:26728401
Crystal Structure of the Measles Virus Nucleoprotein Core in Complex with an N-Terminal Region of Phosphoprotein. PMID:26719278
Structurally conserved erythrocyte-binding domain in Plasmodium provides a versatile scaffold for alternate receptor engagement. PMID:26715754
Structural Evolution of the Emerging 2014-2015 GII.17 Noroviruses. PMID:26699640
Characterization and Structural Insights into Selective E1-E2 Interactions in the Human and Plasmodium falciparum SUMO Conjugation Systems. PMID:26697886
Structure of a TCR-Mimic Antibody with Target Predicts Pharmacogenetics. PMID:26688548
Structural basis of interprotein electron transfer in bacterial sulfite oxidation. PMID:26687009
Discrete structural features among interface residue-level classes. PMID:26679043
Structure of the Receptor-Binding Carboxy-Terminal Domain of the Bacteriophage T5 L-Shaped Tail Fibre with and without Its Intra-Molecular Chaperone. PMID:26670244
The terminal phycobilisome emitter, LCM: A light-harvesting pigment with a phytochrome chromophore. PMID:26669441
Crystal structure of a lipoxygenase from Cyanothece sp. may reveal novel features for substrate acquisition. PMID:26667668
Structural insights into the mechanism defining substrate affinity in Arabidopsis thaliana dUTPase: the role of tryptophan 93 in ligand orientation. PMID:26666293
Secondary ubiquitin-RING docking enhances Arkadia and Ark2C E3 ligase activity. PMID:26656854
Structural and Functional Analyses Reveal Insights into the Molecular Properties of the Escherichia coli Z Ring Stabilizing Protein, ZapC. PMID:26655719
Insights from the Structure of Mycobacterium tuberculosis Topoisomerase I with a Novel Protein Fold. PMID:26655023
Nuclear Protein-Only Ribonuclease P2 Structure and Biochemical Characterization Provide Insight into the Conserved Properties of tRNA 5' End Processing Enzymes. PMID:26655022
Artificial domain duplication replicates evolutionary history of ketol-acid reductoisomerases. PMID:26644020
Structural basis of DNA gyrase inhibition by antibacterial QPT-1, anticancer drug etoposide and moxifloxacin. PMID:26640131
Structural Basis of Stereospecificity in the Bacterial Enzymatic Cleavage of β-Aryl Ether Bonds in Lignin. PMID:26637355
Convergent Evolution of Hemoglobin Function in High-Altitude Andean Waterfowl Involves Limited Parallelism at the Molecular Sequence Level. PMID:26637114
Structure of the Helicase Domain of DNA Polymerase Theta Reveals a Possible Role in the Microhomology-Mediated End-Joining Pathway. PMID:26636256
β-Subunit Binding Is Sufficient for Ligands to Open the Integrin αIIbβ3 Headpiece. PMID:26631735
Stonefish toxin defines an ancient branch of the perforin-like superfamily. PMID:26627714
Sent packing: protein engineering generates a new crystal form of Pseudomonas aeruginosa DsbA1 with increased catalytic surface accessibility. PMID:26627647
Ankyrin-mediated self-protection during cell invasion by the bacterial predator Bdellovibrio bacteriovorus. PMID:26626559
Structures of plasmepsin II from Plasmodium falciparum in complex with two hydroxyethylamine-based inhibitors. PMID:26625296
Structure of Spo0M, a sporulation-control protein from Bacillus subtilis. PMID:26625291
The Structure of the RNA-Dependent RNA Polymerase of a Permutotetravirus Suggests a Link between Primer-Dependent and Primer-Independent Polymerases. PMID:26625123
Reactive Center Loop (RCL) Peptides Derived from Serpins Display Independent Coagulation and Immune Modulating Activities. PMID:26620556
Crystal structure of the Z-ring associated cell division protein ZapC from Escherichia coli. PMID:26619764
Crystal Structure and Comparative Sequence Analysis of GmhA from Colwellia psychrerythraea Strain 34H Provides Insight into Functional Similarity with DiaA. PMID:26612680
Structural delineation of stem-loop RNA binding by human TAF15 protein. PMID:26612539
Exploring the heat-induced structural changes of β-lactoglobulin -linoleic acid complex by fluorescence spectroscopy and molecular modeling techniques. PMID:26604382
Structural basis of substrate recognition by a bacterial deubiquitinase important for dynamics of phagosome ubiquitination. PMID:26598703
Structural insights into YfiR sequestering by YfiB in Pseudomonas aeruginosa PAO1. PMID:26593397
Structure of human carbamoyl phosphate synthetase: deciphering the on/off switch of human ureagenesis. PMID:26592762
Optimal Neutralization of Centruroides noxius Venom Is Understood through a Structural Complex between Two Antibody Fragments and the Cn2 Toxin. PMID:26589800
Arenavirus Glycan Shield Promotes Neutralizing Antibody Evasion and Protracted Infection. PMID:26587982
Structural basis for leucine sensing by the Sestrin2-mTORC1 pathway. PMID:26586190
Distribution of single-nucleotide variants on protein-protein interaction sites and its relationship with minor allele frequency. PMID:26580303
Identification of the Elusive Pyruvate Reductase of Chlamydomonas reinhardtii Chloroplasts. PMID:26574578
Structural Plasticity of the Protein Plug That Traps Newly Packaged Genomes in Podoviridae Virions. PMID:26574546
The Structure of the Cyprinid herpesvirus 3 ORF112-Zα·Z-DNA Complex Reveals a Mechanism of Nucleic Acids Recognition Conserved with E3L, a Poxvirus Inhibitor of Interferon Response. PMID:26559969
A Structural Study of CESA1 Catalytic Domain of Arabidopsis Cellulose Synthesis Complex: Evidence for CESA Trimers. PMID:26556795
The Structural and Functional Characterization of Mammalian ADP-dependent Glucokinase. PMID:26555263
Dissecting the Structural Elements for the Activation of β-Ketoacyl-(Acyl Carrier Protein) Reductase from Vibrio cholerae. PMID:26553852
Structural Characterisation of FabG from Yersinia pestis, a Key Component of Bacterial Fatty Acid Synthesis. PMID:26539719
Protein Arginine Methyltransferase 8: Tetrameric Structure and Protein Substrate Specificity. PMID:26529540
Phosphate binding in the active centre of tomato multifunctional nuclease TBN1 and analysis of superhelix formation by the enzyme. PMID:26527269
Structure of a fungal form of aspartate semialdehyde dehydrogenase from Cryptococcus neoformans. PMID:26527262
Structural insights into the interaction of human IgG1 with FcγRI: no direct role of glycans in binding. PMID:26527150
Structural and Enzymatic Characterization of a Nucleoside Diphosphate Sugar Hydrolase from Bdellovibrio bacteriovorus. PMID:26524597
Structural basis for catalytic activation by the human ZNF451 SUMO E3 ligase. PMID:26524494
Mechanistic basis of Nek7 activation through Nek9 binding and induced dimerization. PMID:26522158
Understanding the fabric of protein crystals: computational classification of biological interfaces and crystal contacts. PMID:26508758
DynaFace: Discrimination between Obligatory and Non-obligatory Protein-Protein Interactions Based on the Complex's Dynamics. PMID:26506003
Cryo-EM structures elucidate neutralizing mechanisms of anti-chikungunya human monoclonal antibodies with therapeutic activity. PMID:26504196
Structural Dissection of the Maltodextrin Disproportionation Cycle of the Arabidopsis Plastidial Disproportionating Enzyme 1 (DPE1). PMID:26504082
Crystal structure of the RNA-dependent RNA polymerase from influenza C virus. PMID:26503046
CAB-Align: A Flexible Protein Structure Alignment Method Based on the Residue-Residue Contact Area. PMID:26502070
PDB-Explorer: a web-based interactive map of the protein data bank in shape space. PMID:26493835
Structural basis for suppression of hypernegative DNA supercoiling by E. coli topoisomerase I. PMID:26490962
Heterodimerization of Two Pathological Mutants Enhances the Activity of Human Phosphomannomutase2. PMID:26488408
Structure and Sequence Analyses of Clustered Protocadherins Reveal Antiparallel Interactions that Mediate Homophilic Specificity. PMID:26481813
Mechanism of eIF6 release from the nascent 60S ribosomal subunit. PMID:26479198
PDBe: improved accessibility of macromolecular structure data from PDB and EMDB. PMID:26476444
The structure of Erb1-Ytm1 complex reveals the functional importance of a high-affinity binding between two β-propellers during the assembly of large ribosomal subunits in eukaryotes. PMID:26476442
Glycosyltransferase complexes in eukaryotes: long-known, prevalent but still unrecognized. PMID:26474840
Structural and Functional Analysis of Murine Polyomavirus Capsid Proteins Establish the Determinants of Ligand Recognition and Pathogenicity. PMID:26474293
Discovery and characterization of natural tropolones as inhibitors of the antibacterial target CapF from Staphylococcus aureus. PMID:26471247
Crystal Structure of the Human tRNA m(1)A58 Methyltransferase-tRNA(3)(Lys) Complex: Refolding of Substrate tRNA Allows Access to the Methylation Target. PMID:26470919
Structural Characterisation of the Beta-Ketoacyl-Acyl Carrier Protein Synthases, FabF and FabH, of Yersinia pestis. PMID:26469877
Structure of ATP synthase from Paracoccus denitrificans determined by X-ray crystallography at 4.0 Å resolution. PMID:26460036
Complement Evasion Mediated by Enhancement of Captured Factor H: Implications for Protection of Self-Surfaces from Complement. PMID:26459349
Structural analysis of the KRIT1 ankyrin repeat and FERM domains reveals a conformationally stable ARD-FERM interface. PMID:26458359
Gating machinery of InsP3R channels revealed by electron cryomicroscopy. PMID:26458101
Carbon Dioxide "Trapped" in a β-Carbonic Anhydrase. PMID:26457866
High-resolution structures of Lactobacillus salivarius transketolase in the presence and absence of thiamine pyrophosphate. PMID:26457526
Extension of resolution and oligomerization-state studies of 2,4'-dihydroxyacetophenone dioxygenase from Alcaligenes sp. 4HAP. PMID:26457516
Structure of the HECT domain of human WWP2. PMID:26457515
Structure and binding properties of a cameloid nanobody raised against KDM5B. PMID:26457512
Structure of the response regulator RPA3017 involved in red-light signaling in Rhodopseudomonas palustris. PMID:26457509
Sequence specificity between interacting and non-interacting homologs identifies interface residues--a homodimer and monomer use case. PMID:26449222
PPCheck: A Webserver for the Quantitative Analysis of Protein-Protein Interfaces and Prediction of Residue Hotspots. PMID:26448684
Structural basis of Ornithine Decarboxylase inactivation and accelerated degradation by polyamine sensor Antizyme1. PMID:26443277
Towards the molecular mechanism of the integration of peroxisomal membrane proteins. PMID:26434995
An extended dsRBD is required for post-transcriptional modification in human tRNAs. PMID:26429968
A conserved charged single α-helix with a putative steric role in paraspeckle formation. PMID:26428695
KSHV but not MHV-68 LANA induces a strong bend upon binding to terminal repeat viral DNA. PMID:26424851
The structure of Legionella pneumophila LegK4 type four secretion system (T4SS) effector reveals a novel dimeric eukaryotic-like kinase. PMID:26419332
Structure and Sialyllactose Binding of the Carboxy-Terminal Head Domain of the Fibre from a Siadenovirus, Turkey Adenovirus 3. PMID:26418008
Structural and Functional Characterization of the Hazelnut Allergen Cor a 8. PMID:26417906
Structural basis for gene regulation by a B12-dependent photoreceptor. PMID:26416754
Structure of Liver Receptor Homolog-1 (NR5A2) with PIP3 hormone bound in the ligand binding pocket. PMID:26416531
A chimeric prokaryotic pentameric ligand-gated channel reveals distinct pathways of activation. PMID:26415570
The Structure of Plasmodium falciparum Blood-Stage 6-Cys Protein Pf41 Reveals an Unexpected Intra-Domain Insertion Required for Pf12 Coordination. PMID:26414347
Reassembly and co-crystallization of a family 9 processive endoglucanase from its component parts: structural and functional significance of the intermodular linker. PMID:26401442
The activity of CouR, a MarR family transcriptional regulator, is modulated through a novel molecular mechanism. PMID:26400178
X-Ray Structure and Mutagenesis Studies of the N-Isopropylammelide Isopropylaminohydrolase, AtzC. PMID:26390431
Conformational toggling controls target site choice for the heteromeric transposase element Tn7. PMID:26384427
Methylatable Signaling Helix Coordinated Inhibitory Receiver Domain in Sensor Kinase Modulates Environmental Stress Response in Bacillus Cereus. PMID:26379238
Structural and Thermodynamic Basis of Epitope Binding by Neutralizing and Nonneutralizing Forms of the Anti-HIV-1 Antibody 4E10. PMID:26378169
Protein-Protein Interfaces in Viral Capsids Are Structurally Unique. PMID:26375252
Evidence for cooperative tandem binding of hnRNP C RRMs in mRNA processing. PMID:26370582
A structural dissection of large protein-protein crystal packing contacts. PMID:26370141
Calcium-controlled conformational choreography in the N-terminal half of adseverin. PMID:26365202
Electrostatic Interactions between Complement Regulator CD46(SCR1-2) and Adenovirus Ad11/Ad21 Fiber Protein Knob. PMID:26357573
CarD uses a minor groove wedge mechanism to stabilize the RNA polymerase open promoter complex. PMID:26349034
Dimerization of lipocalin allergens. PMID:26346541
The Landscape of Intertwined Associations in Homooligomeric Proteins. PMID:26340815
An Integrated Framework Advancing Membrane Protein Modeling and Design. PMID:26325167
Structural Basis for Oxygen Activation at a Heterodinuclear Manganese/Iron Cofactor. PMID:26324712
Crystal Structure of the Michaelis Complex between Tissue-type Plasminogen Activator and Plasminogen Activators Inhibitor-1. PMID:26324706
Structural analysis of Clostridium botulinum neurotoxin type D as a platform for the development of targeted secretion inhibitors. PMID:26324071
Structure of the N-terminal dimerization domain of CEACAM7. PMID:26323304
Structure of mitochondrial poly(A) RNA polymerase reveals the structural basis for dimerization, ATP selectivity and the SPAX4 disease phenotype. PMID:26319014
Mechanistic Implications of the Unique Structural Features and Dimerization of the Cytoplasmic Domain of the Pseudomonas Sigma Regulator, PupR. PMID:26313375
Structural analysis of fungus-derived FAD glucose dehydrogenase. PMID:26311535
Weak conservation of structural features in the interfaces of homologous transient protein-protein complexes. PMID:26311309
The Cell Shape-determining Csd6 Protein from Helicobacter pylori Constitutes a New Family of L,D-Carboxypeptidase. PMID:26306031
Allosteric activation of apicomplexan calcium-dependent protein kinases. PMID:26305940
Structural basis of pathogen recognition by an integrated HMA domain in a plant NLR immune receptor. PMID:26304198
Loss of a Functionally and Structurally Distinct ld-Transpeptidase, LdtMt5, Compromises Cell Wall Integrity in Mycobacterium tuberculosis. PMID:26304120
In Vivo Formation of the Protein Disulfide Bond That Enhances the Thermostability of Diphosphomevalonate Decarboxylase, an Intracellular Enzyme from the Hyperthermophilic Archaeon Sulfolobus solfataricus. PMID:26303832
Trichodysplasia spinulosa-Associated Polyomavirus Uses a Displaced Binding Site on VP1 to Engage Sialylated Glycolipids. PMID:26302170
Structure of Ribosomal Silencing Factor Bound to Mycobacterium tuberculosis Ribosome. PMID:26299947
Structure of the Glycosyltransferase Ktr4p from Saccharomyces cerevisiae. PMID:26296208
Structure and Biophysical Properties of a Triple-Stranded Beta-Helix Comprising the Central Spike of Bacteriophage T4. PMID:26295253
Rhoptry Proteins ROP5 and ROP18 Are Major Murine Virulence Factors in Genetically Divergent South American Strains of Toxoplasma gondii. PMID:26291965
Polyhedra structures and the evolution of the insect viruses. PMID:26291392
In silico mechanistic analysis of IRF3 inactivation and high-risk HPV E6 species-dependent drug response. PMID:26289783
Role of a non-canonical surface of Rad6 in ubiquitin conjugating activity. PMID:26286193
Evolution of plant δ(1)-pyrroline-5-carboxylate reductases from phylogenetic and structural perspectives. PMID:26284089
Structural basis for quinine-dependent antibody binding to platelet integrin αIIbβ3. PMID:26282540
A model for non-obligate oligomer formation in protein aggregration. PMID:26282203
Architecture of the synaptotagmin-SNARE machinery for neuronal exocytosis. PMID:26280336
Structural Modeling of GR Interactions with the SWI/SNF Chromatin Remodeling Complex and C/EBP. PMID:26278180
A Structural View of Negative Regulation of the Toll-like Receptor-Mediated Inflammatory Pathway. PMID:26276688
Structural Basis for the ATP-dependent Configuration of Adenylation Active Site in Bacillus subtilis o-Succinylbenzoyl-CoA Synthetase. PMID:26276389
Dimerization of elongator protein 1 is essential for Elongator complex assembly. PMID:26261306
The crystal structure of the thiocyanate-forming protein from Thlaspi arvense, a kelch protein involved in glucosinolate breakdown. PMID:26260516
Structural basis for recognition and remodeling of the TBP:DNA:NC2 complex by Mot1. PMID:26258880
Structure of Rab11-FIP3-Rabin8 reveals simultaneous binding of FIP3 and Rabin8 effectors to Rab11. PMID:26258637
Crystal structures of the PsbS protein essential for photoprotection in plants. PMID:26258636
Crystal structure analysis of c4763, a uropathogenic Escherichia coli-specific protein. PMID:26249697
Structures of Pseudomonas aeruginosa β-ketoacyl-(acyl-carrier-protein) synthase II (FabF) and a C164Q mutant provide templates for antibacterial drug discovery and identify a buried potassium ion and a ligand-binding site that is an artefact of the crystal form. PMID:26249693
Structure of α-carbonic anhydrase from the human pathogen Helicobacter pylori. PMID:26249690
The soluble Y115E-Y117E variant of human glutaminyl cyclase is a valid target for X-ray and NMR screening of inhibitors against Alzheimer disease. PMID:26249687
Structure of the human MLH1 N-terminus: implications for predisposition to Lynch syndrome. PMID:26249686
Structure of recombinant prolidase from Thermococcus sibiricus in space group P21221. PMID:26249680
Structural and biophysical characterization of the α-carbonic anhydrase from the gammaproteobacterium Thiomicrospira crunogena XCL-2: insights into engineering thermostable enzymes for CO2 sequestration. PMID:26249355
Structural basis for drug-induced allosteric changes to human β-cardiac myosin motor activity. PMID:26246073
Functional significance of protein assemblies predicted by the crystal structure of the restriction endonuclease BsaWI. PMID:26240380
Identification of a functional hotspot on ubiquitin required for stimulation of methyltransferase activity on chromatin. PMID:26240340
Molecular docking to explore the possible binding mode of potential inhibitors of thioredoxin glutathione reductase. PMID:26239395
Crystal structure, biochemical and cellular activities demonstrate separate functions of MTH1 and MTH2. PMID:26238318
The tuberculosis necrotizing toxin kills macrophages by hydrolyzing NAD. PMID:26237511
The mammalian autophagy initiator complex contains 2 HORMA domain proteins. PMID:26236954
Regulation of the PI3K pathway through a p85α monomer-homodimer equilibrium. PMID:26222500
Structure of the eukaryotic MCM complex at 3.8 Å. PMID:26222030
Structure of human MDM2 complexed with RPL11 reveals the molecular basis of p53 activation. PMID:26220995
Globular and disordered-the non-identical twins in protein-protein interactions. PMID:26217672
Structures of the Ultra-High-Affinity Protein-Protein Complexes of Pyocins S2 and AP41 and Their Cognate Immunity Proteins from Pseudomonas aeruginosa. PMID:26215615
Domain-Swapping Switch Point in Ste20 Protein Kinase SPAK. PMID:26208601
Structural basis for the antipolymer activity of Hb ζ2βs2 trapped in a tense conformation. PMID:26207073
Crystal structure of the Ego1-Ego2-Ego3 complex and its role in promoting Rag GTPase-dependent TORC1 signaling. PMID:26206314
Biogenesis and structure of a type VI secretion membrane core complex. PMID:26200339
Sperm Lysozyme-Like Protein 1 (SLLP1), an intra-acrosomal oolemmal-binding sperm protein, reveals filamentous organization in protein crystal form. PMID:26198801
A structural snapshot of type II pilus formation in Streptococcus pneumoniae. PMID:26198632
Structure of human ST8SiaIII sialyltransferase provides insight into cell-surface polysialylation. PMID:26192331
STIL binding to Polo-box 3 of PLK4 regulates centriole duplication. PMID:26188084
Thermostable Carbonic Anhydrases in Biotechnological Applications. PMID:26184158
Specific GFP-binding artificial proteins (αRep): a new tool for in vitro to live cell applications. PMID:26182430
Prediction of stability changes upon mutation in an icosahedral capsid. PMID:26178267
A hybrid method for protein-protein interface prediction. PMID:26178156
Cofactor-induced reversible folding of Flavodoxin-4 from Lactobacillus acidophilus. PMID:26177955
Structure and Evolution of the Archaeal Lipid Synthesis Enzyme sn-Glycerol-1-phosphate Dehydrogenase. PMID:26175150
Molecular mechanism of the dual activity of 4EGI-1: Dissociating eIF4G from eIF4E but stabilizing the binding of unphosphorylated 4E-BP1. PMID:26170285
Structure of the stationary phase survival protein YuiC from B.subtilis. PMID:26163297
Dimerization-Induced Allosteric Changes of the Oxyanion-Hole Loop Activate the Pseudorabies Virus Assemblin pUL26N, a Herpesvirus Serine Protease. PMID:26161660
Structure and functional properties of Norrin mimic Wnt for signalling with Frizzled4, Lrp5/6, and proteoglycan. PMID:26158506
Crystal Structures of a Hyperthermophilic Archaeal Homoserine Dehydrogenase Suggest a Novel Cofactor Binding Mode for Oxidoreductases. PMID:26154028
Structural and functional studies of the Mycobacterium tuberculosis VapBC30 toxin-antitoxin system: implications for the design of novel antimicrobial peptides. PMID:26150422
Structural basis for the RING-catalyzed synthesis of K63-linked ubiquitin chains. PMID:26148049
Molecular Characterization of LubX: Functional Divergence of the U-Box Fold by Legionella pneumophila. PMID:26146184
Structure of human saposin A at lysosomal pH. PMID:26144235
Structural basis for substrate recognition and processive cleavage mechanisms of the trimeric exonuclease PhoExo I. PMID:26138487
Linking structural features of protein complexes and biological function. PMID:26131659
Structural basis for the activation of the C. elegans noncanonical cytoplasmic poly(A)-polymerase GLD-2 by GLD-3. PMID:26124149
Structural asymmetry in a conserved signaling system that regulates division, replication, and virulence of an intracellular pathogen. PMID:26124143
Archaeal actin from a hyperthermophile forms a single-stranded filament. PMID:26124094
Structural and Biochemical Characterization of the Francisella tularensis Pathogenicity Regulator, Macrophage Locus Protein A (MglA). PMID:26121147
Structural Basis for the Specificity of Human NUDT16 and Its Regulation by Inosine Monophosphate. PMID:26121039
Assembly of the Ebola Virus Nucleoprotein from a Chaperoned VP35 Complex. PMID:26119732
Structures of the T. brucei kRNA editing factor MRB1590 reveal unique RNA-binding pore motif contained within an ABC-ATPase fold. PMID:26117548
Structural and Biochemical Characterization of AidC, a Quorum-Quenching Lactonase with Atypical Selectivity. PMID:26115006
Structural and Functional Analysis of Human HtrA3 Protease and Its Subdomains. PMID:26110759
Light Signaling Mechanism of Two Tandem Bacteriophytochromes. PMID:26095026
Cocrystal Structures of Antibody N60-i3 and Antibody JR4 in Complex with gp120 Define More Cluster A Epitopes Involved in Effective Antibody-Dependent Effector Function against HIV-1. PMID:26085162
Structural Characterization of Bardet-Biedl Syndrome 9 Protein (BBS9). PMID:26085087
Cross Talk between KGF and KITLG Proteins Implicated with Ovarian Folliculogenesis in Buffalo Bubalus bubalis. PMID:26083339
Molecular basis for the inhibition of β-hydroxyacyl-ACP dehydratase HadAB complex from Mycobacterium tuberculosis by flavonoid inhibitors. PMID:26081470
Crystal Structure of Hcp from Acinetobacter baumannii: A Component of the Type VI Secretion System. PMID:26079269
Kar1 binding to Sfi1 C-terminal regions anchors the SPB bridge to the nuclear envelope. PMID:26076691
The Anopheles-midgut APN1 structure reveals a new malaria transmission-blocking vaccine epitope. PMID:26075520
MemProtMD: Automated Insertion of Membrane Protein Structures into Explicit Lipid Membranes. PMID:26073602
The non-detergent sulfobetaine-201 acts as a pharmacological chaperone to promote folding and crystallization of the type II TGF-β receptor extracellular domain. PMID:26073093
The structure of the folded domain from the signature multifunctional protein ICP27 from herpes simplex virus-1 reveals an intertwined dimer. PMID:26062451
Structure of the catalytic domain of Mre11 from Chaetomium thermophilum. PMID:26057807
Structure of the MarR family protein Rv0880 from Mycobacterium tuberculosis. PMID:26057805
The structure of a contact-dependent growth-inhibition (CDI) immunity protein from Neisseria meningitidis MC58. PMID:26057799
High-resolution crystal structure of the leucine-rich repeat domain of the human tumour suppressor PP32A (ANP32A). PMID:26057796
Structure of human dual-specificity phosphatase 7, a potential cancer drug target. PMID:26057789
The structure of hookworm platelet inhibitor (HPI), a CAP superfamily member from Ancylostoma caninum. PMID:26057788
3-Sulfinopropionyl-coenzyme A (3SP-CoA) desulfinase from Advenella mimigardefordensis DPN7(T): crystal structure and function of a desulfinase with an acyl-CoA dehydrogenase fold. PMID:26057676
Structure-guided residence time optimization of a dabigatran reversal agent. PMID:26047352
Crystal Structure of the Vaccinia Virus Uracil-DNA Glycosylase in Complex with DNA. PMID:26045555
Crystal Structure and Substrate Recognition of Cellobionic Acid Phosphorylase, Which Plays a Key Role in Oxidative Cellulose Degradation by Microbes. PMID:26041776
Structural, functional, and genetic analyses of the actinobacterial transcription factor RbpA. PMID:26040003
Crystal structure of caspase recruiting domain (CARD) of apoptosis repressor with CARD (ARC) and its implication in inhibition of apoptosis. PMID:26038885
EsxB, a secreted protein from Bacillus anthracis forms two distinct helical bundles. PMID:26032645
Atomic Structure of GRK5 Reveals Distinct Structural Features Novel for G Protein-coupled Receptor Kinases. PMID:26032409
Binding of undamaged double stranded DNA to vaccinia virus uracil-DNA Glycosylase. PMID:26031450
Structural Analysis of Der p 1-Antibody Complexes and Comparison with Complexes of Proteins or Peptides with Monoclonal Antibodies. PMID:26026055
The EBNA-2 N-Terminal Transactivation Domain Folds into a Dimeric Structure Required for Target Gene Activation. PMID:26024477
Structural transition in Bcl-xL and its potential association with mitochondrial calcium ion transport. PMID:26023881
Structural Basis for the Stereochemical Control of Amine Installation in Nucleotide Sugar Aminotransferases. PMID:26023720
Structure of a bacterial toxin-activating acyltransferase. PMID:26016525
Modeling of interaction between cytochrome c and the WD domains of Apaf-1: bifurcated salt bridges underlying apoptosome assembly. PMID:26014357
The homo-oligomerisation of both Sas-6 and Ana2 is required for efficient centriole assembly in flies. PMID:26002084
Exploring Multimodularity in Plant Cell Wall Deconstruction: STRUCTURAL AND FUNCTIONAL ANALYSIS OF Xyn10C CONTAINING THE CBM22-1-CBM22-2 TANDEM. PMID:26001782
Crystal structure of the fibre head domain of bovine adenovirus 4, a ruminant atadenovirus. PMID:25994880
Distinctive Structure of the EphA3/Ephrin-A5 Complex Reveals a Dual Mode of Eph Receptor Interaction for Ephrin-A5. PMID:25993310
Antibodies to Interleukin-2 Elicit Selective T Cell Subset Potentiation through Distinct Conformational Mechanisms. PMID:25992858
Structure of Slitrk2-PTPδ complex reveals mechanisms for splicing-dependent trans-synaptic adhesion. PMID:25989451
Anti-CD28 Antibody-Initiated Cytokine Storm in Canines. PMID:25988188
A Mimivirus Enzyme that Participates in Viral Entry. PMID:25982526
Aldolases Utilize Different Oligomeric States To Preserve Their Functional Dynamics. PMID:25982518
Opioid receptors: Structural and mechanistic insights into pharmacology and signaling. PMID:25981301
Transmembrane Complexes of DAP12 Crystallized in Lipid Membranes Provide Insights into Control of Oligomerization in Immunoreceptor Assembly. PMID:25981043
Structure and Biophysical Characterization of the S-Adenosylmethionine-dependent O-Methyltransferase PaMTH1, a Putative Enzyme Accumulating during Senescence of Podospora anserina. PMID:25979334
Neuronal Calcium Sensor-1 Binds the D2 Dopamine Receptor and G-protein-coupled Receptor Kinase 1 (GRK1) Peptides Using Different Modes of Interactions. PMID:25979333
Structural and Kinetic Characterization of Thymidine Kinase from Leishmania major. PMID:25978379
The structure of FMNL2-Cdc42 yields insights into the mechanism of lamellipodia and filopodia formation. PMID:25963737
Viral receptor-binding site antibodies with diverse germline origins. PMID:25959776
High-resolution Crystal Structure of Dimeric VP40 From Sudan ebolavirus. PMID:25957961
Structural Studies of Potassium Transport Protein KtrA Regulator of Conductance of K+ (RCK) C Domain in Complex with Cyclic Diadenosine Monophosphate (c-di-AMP). PMID:25957408
An Extended Surface Loop on Toxoplasma gondii Apical Membrane Antigen 1 (AMA1) Governs Ligand Binding Selectivity. PMID:25955165
Evidence of Kinetic Cooperativity in Dimeric Ketopantoate Reductase from Staphylococcus aureus. PMID:25946571
Structure of a CutA1 divalent-cation tolerance protein from Cryptosporidium parvum, the protozoal parasite responsible for cryptosporidiosis. PMID:25945704
Structural insights into the binding of the human receptor for advanced glycation end products (RAGE) by S100B, as revealed by an S100B-RAGE-derived peptide complex. PMID:25945582
Structural and functional analysis of betaine aldehyde dehydrogenase from Staphylococcus aureus. PMID:25945581
NMR structure of the myristylated feline immunodeficiency virus matrix protein. PMID:25941825
Repulsive guidance molecule is a structural bridge between neogenin and bone morphogenetic protein. PMID:25938661
The Structure of the T190M Mutant of Murine α-Dystroglycan at High Resolution: Insight into the Molecular Basis of a Primary Dystroglycanopathy. PMID:25932631
Crystal Structure of Allophycocyanin from Marine Cyanobacterium Phormidium sp. A09DM. PMID:25923120
How release of phosphate from mammalian F1-ATPase generates a rotary substep. PMID:25918412
Crystal structure of the human mitochondrial chaperonin symmetrical football complex. PMID:25918392
Architecture of the ubiquitylation module of the yeast Ccr4-Not complex. PMID:25914052
Stock-based detection of protein oligomeric states in jsPISA. PMID:25908787
Mechanisms of splicing-dependent trans-synaptic adhesion by PTPδ-IL1RAPL1/IL-1RAcP for synaptic differentiation. PMID:25908590
LucY: A Versatile New Fluorescent Reporter Protein. PMID:25906065
The Heptameric SmAP1 and SmAP2 Proteins of the Crenarchaeon Sulfolobus Solfataricus Bind to Common and Distinct RNA Targets. PMID:25905548
Crystal structure of a mirror-image L-RNA aptamer (Spiegelmer) in complex with the natural L-protein target CCL2. PMID:25901662
Structural and functional plasticity of antibiotic resistance nucleotidylyltransferases revealed by molecular characterization of lincosamide nucleotidylyltransferases lnu(A) and lnu(D). PMID:25900373
Structure and function of a short LOV protein from the marine phototrophic bacterium Dinoroseobacter shibae. PMID:25887755
Crystal structure of the DNA polymerase III β subunit (β-clamp) from the extremophile Deinococcus radiodurans. PMID:25886944
High-resolution structure of a type IV pilin from the metal-reducing bacterium Shewanella oneidensis. PMID:25886849
The crystal structure of D-threonine aldolase from Alcaligenes xylosoxidans provides insight into a metal ion assisted PLP-dependent mechanism. PMID:25884707
The carboxy-terminal domain of Erb1 is a seven-bladed ß-propeller that binds RNA. PMID:25880847
Molecular basis for mid-region amyloid-β capture by leading Alzheimer's disease immunotherapies. PMID:25880481
Three-dimensional Structure of a Kunitz-type Inhibitor in Complex with an Elastase-like Enzyme. PMID:25878249
Conserved Streptococcus pneumoniae spirosomes suggest a single type of transformation pilus in competence. PMID:25876066
Advanced ensemble modelling of flexible macromolecules using X-ray solution scattering. PMID:25866658
FlaF Is a β-Sandwich Protein that Anchors the Archaellum in the Archaeal Cell Envelope by Binding the S-Layer Protein. PMID:25865246
Structure of the yeast Bre1 RING domain. PMID:25864391
Domains of Pyrococcus furiosus L-asparaginase fold sequentially and assemble through strong intersubunit associative forces. PMID:25862541
Structure of a single-chain Fv bound to the 17 N-terminal residues of huntingtin provides insights into pathogenic amyloid formation and suppression. PMID:25861763
Expression, purification, crystallization and preliminary crystallographic analysis of a GH20 β-N-acetylglucosaminidase from the marine bacterium Vibrio harveyi. PMID:25849504
Structural and biophysical characterization of an epitope-specific engineered Fab fragment and complexation with membrane proteins: implications for co-crystallization. PMID:25849400
Rgg protein structure-function and inhibition by cyclic peptide compounds. PMID:25847993
X-ray and Cryo-electron Microscopy Structures of Monalysin Pore-forming Toxin Reveal Multimerization of the Pro-form. PMID:25847242
Defining a two-pronged structural model for PB1 (Phox/Bem1p) domain interaction in plant auxin responses. PMID:25839233
The substrate-free and -bound crystal structures of the duplicated taurocyamine kinase from the human parasite Schistosoma mansoni. PMID:25837252
Structural characterization of metal binding to a cold-adapted frataxin. PMID:25832196
Molecular recognition of human ephrinB2 cell surface receptor by an emergent African henipavirus. PMID:25825759
CCM2-CCM3 interaction stabilizes their protein expression and permits endothelial network formation. PMID:25825518
Atomic structures of a bactericidal contractile nanotube in its pre- and postcontraction states. PMID:25822993
Characterization of the flexible lip regions in bacteriophage lambda lysozyme using MD simulations. PMID:25820531
Dimeric c-di-GMP is required for post-translational regulation of alginate production in Pseudomonas aeruginosa. PMID:25817996
Stability of the octameric structure affects plasminogen-binding capacity of streptococcal enolase. PMID:25807546
Crystal structures of the kinase domain of the sulfate-activating complex in Mycobacterium tuberculosis. PMID:25807013
The bactofilin cytoskeleton protein BacM of Myxococcus xanthus forms an extended β-sheet structure likely mediated by hydrophobic interactions. PMID:25803609
Protein domain-level landscape of cancer-type-specific somatic mutations. PMID:25794154
Structural basis for the neutralization of hepatitis E virus by a cross-genotype antibody. PMID:25793314
Crystal structure of barley limit dextrinase-limit dextrinase inhibitor (LD-LDI) complex reveals insights into mechanism and diversity of cereal type inhibitors. PMID:25792743
Structural basis for competitive inhibition of 3,4-dihydroxy-2-butanone-4-phosphate synthase from Vibrio cholerae. PMID:25792735
An integrative approach to the study of filamentous oligomeric assemblies, with application to RecA. PMID:25785454
mRNA maturation in giant viruses: variation on a theme. PMID:25779049
Atomic structure of anthrax protective antigen pore elucidates toxin translocation. PMID:25778700
A crystal structure of the Dengue virus NS5 protein reveals a novel inter-domain interface essential for protein flexibility and virus replication. PMID:25775415
Human DNA polymerase θ grasps the primer terminus to mediate DNA repair. PMID:25775267
Biophysical analysis of anopheles gambiae leucine-rich repeat proteins APL1A1, APL1B [corrected] and APL1C and their interaction with LRIM1. PMID:25775123
Interdomain hydrophobic interactions modulate the thermostability of microbial esterases from the hormone-sensitive lipase family. PMID:25771540
The structure of human SFPQ reveals a coiled-coil mediated polymer essential for functional aggregation in gene regulation. PMID:25765647
Snapshots of ligand entry, malleable binding and induced helical movement in P-glycoprotein. PMID:25760620
Structural characterization of substrate and inhibitor binding to farnesyl pyrophosphate synthase from Pseudomonas aeruginosa. PMID:25760619
An intermolecular binding mechanism involving multiple LysM domains mediates carbohydrate recognition by an endopeptidase. PMID:25760608
Four crystal structures of human LLT1, a ligand of human NKR-P1, in varied glycosylation and oligomerization states. PMID:25760607
Interaction of the amyloid precursor protein-like protein 1 (APLP1) E2 domain with heparan sulfate involves two distinct binding modes. PMID:25760599
Active site and laminarin binding in glycoside hydrolase family 55. PMID:25752603
N463 Glycosylation Site on V5 Loop of a Mutant gp120 Regulates the Sensitivity of HIV-1 to Neutralizing Monoclonal Antibodies VRC01/03. PMID:25751231
Structure of human dipeptidyl peptidase 10 (DPPY): a modulator of neuronal Kv4 channels. PMID:25740212
Virulence regulation with Venus flytrap domains: structure and function of the periplasmic moiety of the sensor-kinase BvgS. PMID:25738876
Fully Human VH Single Domains That Rival the Stability and Cleft Recognition of Camelid Antibodies. PMID:25737448
Structures of the Apo and FAD-bound forms of 2-hydroxybiphenyl 3-monooxygenase (HbpA) locate activity hotspots identified by using directed evolution. PMID:25737306
Dysregulation of transition metal ion homeostasis is the molecular basis for cadmium toxicity in Streptococcus pneumoniae. PMID:25731976
Structure of the type VI secretion system contractile sheath. PMID:25723169
Structural basis for self-assembly of a cytolytic pore lined by protein and lipid. PMID:25716479
Algorithmic approaches to protein-protein interaction site prediction. PMID:25713596
A computational design approach for virtual screening of peptide interactions across K(+) channel families. PMID:25709757
Structural insights into Ca2+-calmodulin regulation of Plectin 1a-integrin β4 interaction in hemidesmosomes. PMID:25703379
Structural and enzymatic analysis of TarM glycosyltransferase from Staphylococcus aureus reveals an oligomeric protein specific for the glycosylation of wall teichoic acid. PMID:25697358
Comparative structural analysis of the caspase family with other clan CD cysteine peptidases. PMID:25697094
Characterization of the mycobacterial acyl-CoA carboxylase holo complexes reveals their functional expansion into amino acid catabolism. PMID:25695631
Essential role of the C-terminal helical domain in active site formation of selenoprotein MsrA from Clostridium oremlandii. PMID:25692691
Minimalistic predictor of protein binding energy: contribution of solvation factor to protein binding. PMID:25692584
Structures of regulatory machinery reveal novel molecular mechanisms controlling B. subtilis nitrogen homeostasis. PMID:25691471
Unique ATPase site architecture triggers cis-mediated synchronized ATP binding in heptameric AAA+-ATPase domain of flagellar regulatory protein FlrC. PMID:25688103
X-domain of peptide synthetases recruits oxygenases crucial for glycopeptide biosynthesis. PMID:25686610
Insights into herpesvirus tegument organization from structural analyses of the 970 central residues of HSV-1 UL36 protein. PMID:25678705
Dimerization of matrix protein is required for budding of respiratory syncytial virus. PMID:25673702
Crystal structure of VmoLac, a tentative quorum quenching lactonase from the extremophilic crenarchaeon Vulcanisaeta moutnovskia. PMID:25670483
Structural characterization of a protective epitope spanning A(H1N1)pdm09 influenza virus neuraminidase monomers. PMID:25668439
How pH modulates the dimer-decamer interconversion of 2-Cys peroxiredoxins from the Prx1 subfamily. PMID:25666622
Models of protein-ligand crystal structures: trust, but verify. PMID:25665575
Structural basis for the recognition of the scaffold protein Frmpd4/Preso1 by the TPR domain of the adaptor protein LGN. PMID:25664792
Structural analysis of DNA binding by C.Csp231I, a member of a novel class of R-M controller proteins regulating gene expression. PMID:25664751
A novel inhibitor of Plasmodium falciparum spermidine synthase: a twist in the tail. PMID:25651815
The activator of apoptosis Smac-DIABLO acts as a tetramer in solution. PMID:25650938
The conundrum of the high-affinity NGF binding site formation unveiled? PMID:25650935
A new suite of tnaA mutants suggests that Escherichia coli tryptophanase is regulated by intracellular sequestration and by occlusion of its active site. PMID:25650045
Crystal structure and biophysical characterization of the nucleoside diphosphate kinase from Leishmania braziliensis. PMID:25643978
Structures of human CCL18, CCL3, and CCL4 reveal molecular determinants for quaternary structures and sensitivity to insulin-degrading enzyme. PMID:25636406
Limited effect of recombinant human mannose-binding lectin on the infection of novel influenza A (H7N9) virus in vitro. PMID:25634695
The shear stress of host cell invasion: exploring the role of biomolecular complexes. PMID:25629317
Structure-function analysis of VapB4 antitoxin identifies critical features of a minimal VapC4 toxin-binding module. PMID:25622615
Crystal structure and functional characterization of photosystem II-associated carbonic anhydrase CAH3 in Chlamydomonas reinhardtii. PMID:25617045
Structures of the N-acetyltransferase domain of Xylella fastidiosa N-acetyl-L-glutamate synthase/kinase with and without a His tag bound to N-acetyl-L-glutamate. PMID:25615976
Structures of Drosophila melanogaster Rab2 and Rab3 bound to GMPPNP. PMID:25615965
Vaccinia virus protein A49 is an unexpected member of the B-cell Lymphoma (Bcl)-2 protein family. PMID:25605733
Dissociation of glucocerebrosidase dimer in solution by its co-factor, saposin C. PMID:25600808
Crystal structure of human persulfide dioxygenase: structural basis of ethylmalonic encephalopathy. PMID:25596185
Structure and sequence analyses of Bacteroides proteins BVU_4064 and BF1687 reveal presence of two novel predominantly-beta domains, predicted to be involved in lipid and cell surface interactions. PMID:25592227
Mechanistic insights into the recycling machine of the SNARE complex. PMID:25581794
Erythromelalgia mutation Q875E Stabilizes the activated state of sodium channel Nav1.7. PMID:25575597
Structural and molecular basis for resistance to aminoglycoside antibiotics by the adenylyltransferase ANT(2″)-Ia. PMID:25564464
Crystal structure of a plant albumin from Cicer arietinum (chickpea) possessing hemopexin fold and hemagglutination activity. PMID:25559942
The multifaceted subunit interfaces of ionotropic glutamate receptors. PMID:25556789
Structure of the human autophagy initiating kinase ULK1 in complex with potent inhibitors. PMID:25551253
Structural basis of DNA recognition by PCG2 reveals a novel DNA binding mode for winged helix-turn-helix domains. PMID:25550425
Conformational dynamics of nonsynonymous variants at protein interfaces reveals disease association. PMID:25546381
The strength and cooperativity of KIT ectodomain contacts determine normal ligand-dependent stimulation or oncogenic activation in cancer. PMID:25544564
Two TIR-like domain containing proteins in a newly emerging zoonotic Staphylococcus aureus strain sequence type 398 are potential virulence factors by impacting on the host innate immune response. PMID:25538689
Structural basis for replication origin unwinding by an initiator primase of plasmid ColE2-P9: duplex DNA unwinding by a single protein. PMID:25538245
Crystal structure of an arginase-like protein from Trypanosoma brucei that evolved without a binuclear manganese cluster. PMID:25536859
Near-atomic resolution for one state of F-actin. PMID:25533486
A novel N-terminal extension in mitochondrial TRAP1 serves as a thermal regulator of chaperone activity. PMID:25531069
Dimeric Structure of the Bacterial Extracellular Foldase PrsA. PMID:25525259
Structural basis for misfolding in myocilin-associated glaucoma. PMID:25524706
Room temperature crystal structure of the fast switching M159T mutant of the fluorescent protein dronpa. PMID:25524427
Use B-factor related features for accurate classification between protein binding interfaces and crystal packing contacts. PMID:25522196
Hen egg-white lysozyme crystallisation: protein stacking and structure stability enhanced by a Tellurium(VI)-centred polyoxotungstate. PMID:25521080
Nanobody binding to a conserved epitope promotes norovirus particle disassembly. PMID:25520510
Crystallographic studies evidencing the high energy tolerance to disrupting the interface disulfide bond of thioredoxin 1 from white leg shrimp Litopenaeus vannamei. PMID:25517346
Structural basis for the auxin-induced transcriptional regulation by Aux/IAA17. PMID:25512488
Structural basis for the interaction of protein S1 with the Escherichia coli ribosome. PMID:25510494
Site-directed mutagenesis reveals regions implicated in the stability and fiber formation of human λ3r light chains. PMID:25505244
A novel phosphatidylinositol 4,5-bisphosphate binding domain mediates plasma membrane localization of ExoU and other patatin-like phospholipases. PMID:25505182
Protein structure annotation resources. PMID:25502191
X-ray crystallographic structure of BshC, a unique enzyme involved in bacillithiol biosynthesis. PMID:25496067
First evidence for substrate channeling between proline catabolic enzymes: a validation of domain fusion analysis for predicting protein-protein interactions. PMID:25492892
Structural features of interfacial tyrosine residue in ROBO1 fibronectin domain-antibody complex: Crystallographic, thermodynamic, and molecular dynamic analyses. PMID:25492858
Structural templates for comparative protein docking. PMID:25488330
RNA-directed remodeling of the HIV-1 protein Rev orchestrates assembly of the Rev-Rev response element complex. PMID:25486594
Crystal structure of the fibre head domain of the Atadenovirus Snake Adenovirus 1. PMID:25486282
Crystallization and preliminary crystallographic analysis of human aquaporin 1 at a resolution of 3.28 Å. PMID:25484221
The structure of the cyanobactin domain of unknown function from PatG in the patellamide gene cluster. PMID:25484206
Structures of heterodimeric POZ domains of Miz1/BCL6 and Miz1/NAC1. PMID:25484205
Insights into autophagosome maturation revealed by the structures of ATG5 with its interacting partners. PMID:25484072
ACHESYM: an algorithm and server for standardized placement of macromolecular models in the unit cell. PMID:25478846
Murine anti-vaccinia virus D8 antibodies target different epitopes and differ in their ability to block D8 binding to CS-E. PMID:25474621
Structural flexibility of a conserved antigenic region in hepatitis C virus glycoprotein E2 recognized by broadly neutralizing antibodies. PMID:25473061
Structure of the F-actin-tropomyosin complex. PMID:25470062
Full-length structure of a monomeric histidine kinase reveals basis for sensory regulation. PMID:25468971
Crystal structure of BamB bound to a periplasmic domain fragment of BamA, the central component of the β-barrel assembly machine. PMID:25468906
The structure and regulation of human muscle α-actinin. PMID:25433700
The RCSB Protein Data Bank: views of structural biology for basic and applied research and education. PMID:25428375
Structural characterization of the late competence protein ComFB from Bacillus subtilis. PMID:25423369
Structure of putrescine aminotransferase from Escherichia coli provides insights into the substrate specificity among class III aminotransferases. PMID:25423189
Stapled HIV-1 peptides recapitulate antigenic structures and engage broadly neutralizing antibodies. PMID:25420104
Epistasis constrains mutational pathways of hemoglobin adaptation in high-altitude pikas. PMID:25415962
Solution structure of the SGTA dimerisation domain and investigation of its interactions with the ubiquitin-like domains of BAG6 and UBL4A. PMID:25415308
Crystal structure of cytomegalovirus IE1 protein reveals targeting of TRIM family member PML via coiled-coil interactions. PMID:25412268
Crystal structure of snake venom acetylcholinesterase in complex with inhibitory antibody fragment Fab410 bound at the peripheral site: evidence for open and closed states of a back door channel. PMID:25411244
Calcium-induced conformational changes of the regulatory domain of human mitochondrial aspartate/glutamate carriers. PMID:25410934
Adeno-associated virus serotype 1 (AAV1)- and AAV5-antibody complex structures reveal evolutionary commonalities in parvovirus antigenic reactivity. PMID:25410874
Structural and functional characterization of a ketosteroid transcriptional regulator of Mycobacterium tuberculosis. PMID:25406313
Evidence for henipavirus spillover into human populations in Africa. PMID:25405640
Crystal structure of Bacillus anthracis virulence regulator AtxA and effects of phosphorylated histidines on multimerization and activity. PMID:25402841
Structural basis for membrane targeting of the BBSome by ARL6. PMID:25402481
Structures of the inducer-binding domain of pentachlorophenol-degrading gene regulator PcpR from Sphingobium chlorophenolicum. PMID:25397598
Structural and functional characterization of methicillin-resistant Staphylococcus aureus's class IIb fructose 1,6-bisphosphate aldolase. PMID:25390935
Exploring nicotinamide cofactor promiscuity in NAD(P)H-dependent flavin containing monooxygenases (FMOs) using natural variation within the phosphate binding loop. Structure and activity of FMOs from Cellvibrio sp. BR and Pseudomonas stutzeri NF13. PMID:25383040
Crystal structure of Bombyx mori lipoprotein 6: comparative structural analysis of the 30-kDa lipoprotein family. PMID:25379889
The prophage-encoded hyaluronate lyase has broad substrate specificity and is regulated by the N-terminal domain. PMID:25378402
Improved contact predictions using the recognition of protein like contact patterns. PMID:25375897
Structure of the methanofuran/methanopterin-biosynthetic enzyme MJ1099 from Methanocaldococcus jannaschii. PMID:25372812
Effect of the L499M mutation of the ascomycetous Botrytis aclada laccase on redox potential and catalytic properties. PMID:25372682
Structural insights into the human RyR2 N-terminal region involved in cardiac arrhythmias. PMID:25372681
Structure-function analysis of heterodimer formation, oligomerization, and receptor binding of the Staphylococcus aureus bi-component toxin LukGH. PMID:25371205
Regulation of the NaV1.5 cytoplasmic domain by calmodulin. PMID:25370050
A robust pipeline for rapid production of versatile nanobody repertoires. PMID:25362362
Structure of a diguanylate cyclase from Thermotoga maritima: insights into activation, feedback inhibition and thermostability. PMID:25360685
Host cofactors and pharmacologic ligands share an essential interface in HIV-1 capsid that is lost upon disassembly. PMID:25356722
The megavirus chilensis Cu,Zn-superoxide dismutase: the first viral structure of a typical cellular copper chaperone-independent hyperstable dimeric enzyme. PMID:25355875
Structure of a cupin protein Plu4264 from Photorhabdus luminescens subsp. laumondii TTO1 at 1.35 Å resolution. PMID:25354690
Structural basis of IL-23 antagonism by an Alphabody protein scaffold. PMID:25354530
A series of PDB-related databanks for everyday needs. PMID:25352545
Structural basis of the proteolytic and chaperone activity of Chlamydia trachomatis CT441. PMID:25349155
Convergent evolution in the assembly of polyubiquitin degradation signals by the Shigella flexneri IpaH9.8 ligase. PMID:25342744
An intramolecular lock facilitates folding and stabilizes the tertiary structure of Streptococcus mutans adhesin P1. PMID:25331888
Structure-based functional characterization of repressor of toxin (Rot), a central regulator of Staphylococcus aureus virulence. PMID:25331435
Structure-function analyses of human kallikrein-related peptidase 2 establish the 99-loop as master regulator of activity. PMID:25326387
A PDB-wide, evolution-based assessment of protein-protein interfaces. PMID:25326082
Structural identification of the Vps18 β-propeller reveals a critical role in the HOPS complex stability and function. PMID:25324549
Identification and structural analysis of an L-asparaginase enzyme from guinea pig with putative tumor cell killing properties. PMID:25320094
Covariance of charged amino acids at positions 322 and 440 of HIV-1 Env contributes to coreceptor specificity of subtype B viruses, and can be used to improve the performance of V3 sequence-based coreceptor usage prediction algorithms. PMID:25313689
Structure and mechanism of the bifunctional CinA enzyme from Thermus thermophilus. PMID:25313401
Structural basis of thymosin-β4/profilin exchange leading to actin filament polymerization. PMID:25313062
Apo, Zn2+-bound and Mn2+-bound structures reveal ligand-binding properties of SitA from the pathogen Staphylococcus pseudintermedius. PMID:25311310
The structure of an LIM-only protein 4 (LMO4) and Deformed epidermal autoregulatory factor-1 (DEAF1) complex reveals a common mode of binding to LMO4. PMID:25310299
Crystal structure of human Ankyrin G death domain. PMID:25307106
Crystal structure of the human fatty acid synthase enoyl-acyl carrier protein-reductase domain complexed with triclosan reveals allosteric protein-protein interface inhibition. PMID:25301948
Investigation of phycobilisome subunit interaction interfaces by coupled cross-linking and mass spectrometry. PMID:25296757
Crystal structures of influenza A virus matrix protein M1: variations on a theme. PMID:25295515
Nucleic Acid Ligands With Protein-like Side Chains: Modified Aptamers and Their Use as Diagnostic and Therapeutic Agents. PMID:25291143
Structural and functional characterization of ybr137wp implicates its involvement in the targeting of tail-anchored proteins to membranes. PMID:25288638
Thermal green protein, an extremely stable, nonaggregating fluorescent protein created by structure-guided surface engineering. PMID:25287913
Insights into the potential function and membrane organization of the TP0435 (Tp17) lipoprotein from Treponema pallidum derived from structural and biophysical analyses. PMID:25287511
Enhancing ubiquitin crystallization through surface-entropy reduction. PMID:25286958
Structural analysis of arabinose-5-phosphate isomerase from Bacteroides fragilis and functional implications. PMID:25286848
The structure of allophycocyanin B from Synechocystis PCC 6803 reveals the structural basis for the extreme redshift of the terminal emitter in phycobilisomes. PMID:25286841
Structural and functional divergence of the aldolase fold in Toxoplasma gondii. PMID:25284756
The structure, stability and pheromone binding of the male mouse protein sex pheromone darcin. PMID:25279835
Structure of the large ribosomal subunit from human mitochondria. PMID:25278503
Structure-based design and functional studies of novel noroviral 3C protease chimaeras offer insights into substrate specificity. PMID:25275273
How periplasmic thioredoxin TlpA reduces bacterial copper chaperone ScoI and cytochrome oxidase subunit II (CoxB) prior to metallation. PMID:25274631
Structure of the complete bacterial SRP Alu domain. PMID:25270875
Functional and structural diversity in GH62 α-L-arabinofuranosidases from the thermophilic fungus Scytalidium thermophilum. PMID:25267315
Molecular Docking of Known Carcinogen 4- (Methyl-nitrosamino)-1-(3-pyridyl)-1-butanone (NNK) with Cyclin Dependent Kinases towards Its Potential Role in Cell Cycle Perturbation. PMID:25258489
An Immuno-informatics driven Epitope study from the molecular interaction of JEV non-structural (NS) proteins with Ribophorin (RPN). PMID:25258484
Kinetic and structural characterization for cofactor preference of succinic semialdehyde dehydrogenase from Streptococcus pyogenes. PMID:25256219
All-atom crystal simulations of DNA and RNA duplexes. PMID:25255706
Structural basis for biomolecular recognition in overlapping binding sites in a diiron enzyme system. PMID:25248368
Homotypic dimerization of a maltose kinase for molecular scaffolding. PMID:25245657
An engineered Axl 'decoy receptor' effectively silences the Gas6-Axl signaling axis. PMID:25242553
Potential for reduction of streptogramin A resistance revealed by structural analysis of acetyltransferase VatA. PMID:25223995
Global analysis of protein structural changes in complex proteomes. PMID:25218519
Duplication of genes in an ATP-binding cassette transport system increases dynamic range while maintaining ligand specificity. PMID:25210043
IRAK4 dimerization and trans-autophosphorylation are induced by Myddosome assembly. PMID:25201411
The structure of alanine racemase from Acinetobacter baumannii. PMID:25195891
Structure of nucleoside diphosphate kinase from pacific shrimp (Litopenaeus vannamei) in binary complexes with purine and pyrimidine nucleoside diphosphates. PMID:25195883
Structural basis for the substrate selectivity of PvuRts1I, a 5-hydroxymethylcytosine DNA restriction endonuclease. PMID:25195760
Structure of the 2,4'-dihydroxyacetophenone dioxygenase from Alcaligenes sp. 4HAP. PMID:25195757
Latent and active abPPO4 mushroom tyrosinase cocrystallized with hexatungstotellurate(VI) in a single crystal. PMID:25195745
Structural basis for the binding specificity of human Recepteur d'Origine Nantais (RON) receptor tyrosine kinase to macrophage-stimulating protein. PMID:25193665
Crystal structure of the mineralocorticoid receptor DNA binding domain in complex with DNA. PMID:25188500
Tracing the evolution of the p53 tetramerization domain. PMID:25185827
Structure and protein-protein interactions of methanol dehydrogenase from Methylococcus capsulatus (Bath). PMID:25185034
Crystallographic evidence of drastic conformational changes in the active site of a flavin-dependent N-hydroxylase. PMID:25184411
Mutations in the ArsA ATPase that restore interaction with the ArsD metallochaperone. PMID:25183649
Mechanistic insight into the conserved allosteric regulation of periplasmic proteolysis by the signaling molecule cyclic-di-GMP. PMID:25182848
Crystal structure of the ectoine hydroxylase, a snapshot of the active site. PMID:25172507
Tetrameric c-di-GMP mediates effective transcription factor dimerization to control Streptomyces development. PMID:25171413
Crystal structure of Clostridium acetobutylicum Aspartate kinase (CaAK): An important allosteric enzyme for amino acids production. PMID:25170437
The TRIM-NHL protein LIN-41 controls the onset of developmental plasticity in Caenorhabditis elegans. PMID:25167051
P. aeruginosa SGNH hydrolase-like proteins AlgJ and AlgX have similar topology but separate and distinct roles in alginate acetylation. PMID:25165982
Chromatin insulator factors involved in long-range DNA interactions and their role in the folding of the Drosophila genome. PMID:25165871
Structural definition of an antibody-dependent cellular cytotoxicity response implicated in reduced risk for HIV-1 infection. PMID:25165110
Conformational plasticity of the Ebola virus matrix protein. PMID:25159197
Structure of the Mycobacterium tuberculosis type VII secretion system chaperone EspG5 in complex with PE25-PPE41 dimer. PMID:25155747
Comparison of histidine recognition in human and trypanosomatid histidyl-tRNA synthetases. PMID:25151410
Structural and biochemical characterization of the Cop9 signalosome CSN5/CSN6 heterodimer. PMID:25144743
A new model for pore formation by cholesterol-dependent cytolysins. PMID:25144725
Collapse of the native structure caused by a single amino acid exchange in human NAD(P)H:quinone oxidoreductase(1.). PMID:25143260
Enhanced potency of a broadly neutralizing HIV-1 antibody in vitro improves protection against lentiviral infection in vivo. PMID:25142607
Integrative structure-function mapping of the nucleoporin Nup133 suggests a conserved mechanism for membrane anchoring of the nuclear pore complex. PMID:25139911
Formation and structures of GroEL:GroES2 chaperonin footballs, the protein-folding functional form. PMID:25136110
Functional characterization and categorization of missense mutations that cause methylmalonyl-CoA mutase (MUT) deficiency. PMID:25125334
Molecular insights into replication initiation by Qβ replicase using ribosomal protein S1. PMID:25122749
Hydration of protein-RNA recognition sites. PMID:25114050
Sac1-Vps74 structure reveals a mechanism to terminate phosphoinositide signaling in the Golgi apparatus. PMID:25113029
Structural basis of nSH2 regulation and lipid binding in PI3Kα. PMID:25105564
trans-Protease activity and structural insights into the active form of the alphavirus capsid protease. PMID:25100849
Crystal structure of the full-length ATPase GspE from the Vibrio vulnificus type II secretion system in complex with the cytoplasmic domain of GspL. PMID:25092625
Crystal structure of the WOPR-DNA complex and implications for Wor1 function in white-opaque switching of Candida albicans. PMID:25091450
Mechanistic basis for functional promiscuity in the TNF and TNF receptor superfamilies: structure of the LIGHT:DcR3 assembly. PMID:25087510
Structure and substrate specificity of a eukaryotic fucosidase from Fusarium graminearum. PMID:25086049
Structural and biophysical analysis of interactions between cod and human uracil-DNA N-glycosylase (UNG) and UNG inhibitor (Ugi). PMID:25084329
Structure-guided functional characterization of enediyne self-sacrifice resistance proteins, CalU16 and CalU19. PMID:25079510
Interactions of protein kinase C-α C1A and C1B domains with membranes: a combined computational and experimental study. PMID:25075641
Diverse modes of binding in structures of Leishmania major N-myristoyltransferase with selective inhibitors. PMID:25075346
Avoidable errors in deposited macromolecular structures: an impediment to efficient data mining. PMID:25075337
Structural insight into activity enhancement and inhibition of H64A carbonic anhydrase II by imidazoles. PMID:25075329
The structure of a purple acid phosphatase involved in plant growth and pathogen defence exhibits a novel immunoglobulin-like fold. PMID:25075326
Structure and mechanism of the phycobiliprotein lyase CpcT. PMID:25074932
Identification of polyketide inhibitors targeting 3-dehydroquinate dehydratase in the shikimate pathway of Enterococcus faecalis. PMID:25072253
Structural and functional analysis show that the Escherichia coli uncharacterized protein YjcS is likely an alkylsulfatase. PMID:25066955
Crystal structure of the lytic CHAP(K) domain of the endolysin LysK from Staphylococcus aureus bacteriophage K. PMID:25064136
Amiloride inhibits the initiation of Coxsackievirus and poliovirus RNA replication by inhibiting VPg uridylylation. PMID:25058507
The bacterial antitoxin HipB establishes a ternary complex with operator DNA and phosphorylated toxin HipA to regulate bacterial persistence. PMID:25056321
The structure of RdDddP from Roseobacter denitrificans reveals that DMSP lyases in the DddP-family are metalloenzymes. PMID:25054772
The crystal structure of BlmI as a model for nonribosomal peptide synthetase peptidyl carrier proteins. PMID:25050442
Structure of the eukaryotic translation initiation factor eIF4E in complex with 4EGI-1 reveals an allosteric mechanism for dissociating eIF4G. PMID:25049413
Pathway of binding of the intrinsically disordered mitochondrial inhibitor protein to F1-ATPase. PMID:25049402
Protein painting reveals solvent-excluded drug targets hidden within native protein-protein interfaces. PMID:25048602
Structural and functional analysis of the anti-malarial drug target prolyl-tRNA synthetase. PMID:25047712
Crystal structures of three representatives of a new Pfam family PF14869 (DUF4488) suggest they function in sugar binding/uptake. PMID:25044324
Computational design of protein antigens that interact with the CDR H3 loop of HIV broadly neutralizing antibody 2F5. PMID:25043744
Identification of the docking site between a type III secretion system ATPase and a chaperone for effector cargo. PMID:25035427
Potent neutralization of vaccinia virus by divergent murine antibodies targeting a common site of vulnerability in L1 protein. PMID:25031354
Peptide-dependent conformational fluctuation determines the stability of the human leukocyte antigen class I complex. PMID:25028510
The structure of the TFIIH p34 subunit reveals a von Willebrand factor A like fold. PMID:25013903
Structural and functional characterization of DUF1471 domains of Salmonella proteins SrfN, YdgH/SssB, and YahO. PMID:25010333
Crystal structure of Schistosoma mansoni arginase, a potential drug target for the treatment of schistosomiasis. PMID:25007099
A new crystal form of a hyperthermophilic endocellulase. PMID:25005081
Structure of Rhodococcus equi virulence-associated protein B (VapB) reveals an eight-stranded antiparallel β-barrel consisting of two Greek-key motifs. PMID:25005079
Structures of the NLRP14 pyrin domain reveal a conformational switch mechanism regulating its molecular interactions. PMID:25004977
Structural and biochemical analyses of alanine racemase from the multidrug-resistant Clostridium difficile strain 630. PMID:25004969
Structural insights into interactions of C/EBP transcriptional activators with the Taz2 domain of p300. PMID:25004968
Structure of pneumococcal peptidoglycan hydrolase LytB reveals insights into the bacterial cell wall remodeling and pathogenesis. PMID:25002590
Characterization of the SAM domain of the PKD-related protein ANKS6 and its interaction with ANKS3. PMID:24998259
Modification and periplasmic translocation of the biofilm exopolysaccharide poly-β-1,6-N-acetyl-D-glucosamine. PMID:24994902
Structure of a new DNA-binding domain which regulates pathogenesis in a wide variety of fungi. PMID:24994900
Crystal structure of the Chlamydomonas starch debranching enzyme isoamylase ISA1 reveals insights into the mechanism of branch trimming and complex assembly. PMID:24993830
Transplanting supersites of HIV-1 vulnerability. PMID:24992528
The immunodominant influenza A virus M158-66 cytotoxic T lymphocyte epitope exhibits degenerate class I major histocompatibility complex restriction in humans. PMID:24990997
Structural dynamics of the two-component response regulator RstA in recognition of promoter DNA element. PMID:24990372
Structure of the C. elegans ZYG-1 cryptic polo box suggests a conserved mechanism for centriolar docking of Plk4 kinases. PMID:24980795
B-cell epitopes in GroEL of Francisella tularensis. PMID:24968190
Immunization with a functional protein complex required for erythrocyte invasion protects against lethal malaria. PMID:24958881
Engagement of nucleotide-binding oligomerization domain-containing protein 1 (NOD1) by receptor-interacting protein 2 (RIP2) is insufficient for signal transduction. PMID:24958724
Molecular mechanism for Rabex-5 GEF activation by Rabaptin-5. PMID:24957337
Polymorphic Protein Crystal Growth: Influence of Hydration and Ions in Glucose Isomerase. PMID:24955067
Identification of promiscuous ene-reductase activity by mining structural databases using active site constellations. PMID:24954722
Structure-based characterization of multiprotein complexes. PMID:24954616
A G-quadruplex-containing RNA activates fluorescence in a GFP-like fluorophore. PMID:24952597
Characterization of two homologous 2'-O-methyltransferases showing different specificities for their tRNA substrates. PMID:24951554
Structures of bacterial kynurenine formamidase reveal a crowded binuclear zinc catalytic site primed to generate a potent nucleophile. PMID:24942958
Maturation of Rhizobium leguminosarum hydrogenase in the presence of oxygen requires the interaction of the chaperone HypC and the scaffolding protein HupK. PMID:24942742
Structure-function studies with the unique hexameric form II ribulose-1,5-bisphosphate carboxylase/oxygenase (Rubisco) from Rhodopseudomonas palustris. PMID:24942737
Structural and functional insight into TAF1-TAF7, a subcomplex of transcription factor II D. PMID:24927529
BioAssemblyModeler (BAM): user-friendly homology modeling of protein homo- and heterooligomers. PMID:24922057
Insight into the architecture of the NuRD complex: structure of the RbAp48-MTA1 subcomplex. PMID:24920672
Rational design, preparation, and characterization of a therapeutic enzyme mutant with improved stability and function for cocaine detoxification. PMID:24919140
RsaM: a transcriptional regulator of Burkholderia spp. with novel fold. PMID:24916958
A tale of tails: deciphering the contribution of terminal tails to the biochemical properties of two Dps proteins from Streptomyces coelicolor. PMID:24915944
Structure of transportin SR2, a karyopherin involved in human disease, in complex with Ran. PMID:24915079
Structures and binding specificity of galactose- and mannose-binding lectins from champedak: differences from jackfruit lectins. PMID:24915077
Structure of the LCMV nucleoprotein provides a template for understanding arenavirus replication and immunosuppression. PMID:24914986
Structural and functional characterization of human and murine C5a anaphylatoxins. PMID:24914981
Crystal structure of human CRMP-4: correction of intensities for lattice-translocation disorder. PMID:24914979
Structural and functional analysis of the human spliceosomal DEAD-box helicase Prp28. PMID:24914973
Crystal structure of a human GABAA receptor. PMID:24909990
Structural insights into SraP-mediated Staphylococcus aureus adhesion to host cells. PMID:24901708
Structural insight into the tetramerization of an iterative ketoreductase siam through aromatic residues in the interfaces. PMID:24901639
Structural bioinformatics of the interactome. PMID:24895853
The structure of a far-red fluorescent protein, AQ143, shows evidence in support of reported red-shifting chromophore interactions. PMID:24888769
Molecular characterization of novel pyridoxal-5'-phosphate-dependent enzymes from the human microbiome. PMID:24888348
High-resolution crystal structure of spin labelled (T21R1) azurin from Pseudomonas aeruginosa: a challenging structural benchmark for in silico spin labelling algorithms. PMID:24884565
Prediction and redesign of protein-protein interactions. PMID:24878423
Structural basis for dimerization and catalysis of a novel esterase from the GTSAG motif subfamily of the bacterial hormone-sensitive lipase family. PMID:24867954
Structural studies of an anti-inflammatory lectin from Canavalia boliviana seeds in complex with dimannosides. PMID:24865454
Glycan specificity of the Vibrio vulnificus hemolysin lectin outlines evolutionary history of membrane targeting by a toxin family. PMID:24862282
Structure of the Acinetobacter baumannii dithiol oxidase DsbA bound to elongation factor EF-Tu reveals a novel protein interaction site. PMID:24860094
VARP is recruited on to endosomes by direct interaction with retromer, where together they function in export to the cell surface. PMID:24856514
Intrinsic conformational plasticity of native EmrE provides a pathway for multidrug resistance. PMID:24856154
Identification of functionally important residues of the silkmoth pheromone biosynthesis-activating neuropeptide receptor, an insect ortholog of the vertebrate neuromedin U receptor. PMID:24847080
Re-examining how complexin inhibits neurotransmitter release. PMID:24842998
Drastic changes in conformational dynamics of the antiterminator M2-1 regulate transcription efficiency in Pneumovirinae. PMID:24842877
Use of cysteine-reactive cross-linkers to probe conformational flexibility of human DJ-1 demonstrates that Glu18 mutations are dimers. PMID:24832775
Structure of a sedoheptulose 7-phosphate cyclase: ValA from Streptomyces hygroscopicus. PMID:24832673
A loose domain swapping organization confers a remarkable stability to the dimeric structure of the arginine binding protein from Thermotoga maritima. PMID:24832102
Crystal structure of the dithiol oxidase DsbA enzyme from proteus mirabilis bound non-covalently to an active site peptide ligand. PMID:24831013
Protein-protein interface detection using the energy centrality relationship (ECR) characteristic of proteins. PMID:24830938
The structural analysis of shark IgNAR antibodies reveals evolutionary principles of immunoglobulins. PMID:24830426
Functional and structural properties of a novel protein and virulence factor (Protein sHIP) in Streptococcus pyogenes. PMID:24825900
The structural and functional basis of catalysis mediated by NAD(P)H:acceptor Oxidoreductase (FerB) of Paracoccus denitrificans. PMID:24817153
Crystallographic and kinetic study of riboflavin synthase from Brucella abortus, a chemotherapeutic target with an enhanced intrinsic flexibility. PMID:24816110
Structure of sulfamidase provides insight into the molecular pathology of mucopolysaccharidosis IIIA. PMID:24816101
Effect of CDR3 sequences and distal V gene residues in regulating TCR-MHC contacts and ligand specificity. PMID:24813203
Insights into the architecture of the eIF2Bα/β/δ regulatory subcomplex. PMID:24811713
Structural insights into the lipoprotein outer membrane regulator of penicillin-binding protein 1B. PMID:24808177
Structural basis for phosphorylation-dependent recruitment of Tel2 to Hsp90 by Pih1. PMID:24794838
A functional feature analysis on diverse protein-protein interactions: application for the prediction of binding affinity. PMID:24789327
Insights into the mechanism of deubiquitination by JAMM deubiquitinases from cocrystal structures of the enzyme with the substrate and product. PMID:24787148
The malaria parasite egress protease SUB1 is a calcium-dependent redox switch subtilisin. PMID:24785947
The major cockroach allergen Bla g 4 binds tyramine and octopamine. PMID:24769496
Antibody 8ANC195 reveals a site of broad vulnerability on the HIV-1 envelope spike. PMID:24767986
Interactions of IgG1 CH2 and CH3 Domains with FcRn. PMID:24765095
Dimerization interface of 3-hydroxyacyl-CoA dehydrogenase tunes the formation of its catalytic intermediate. PMID:24763278
Mechanism of the Rpn13-induced activation of Uch37. PMID:24752541
Entrapment of DNA in an intersubunit tunnel system of a single-stranded DNA-binding protein. PMID:24744237
Potent dengue virus neutralization by a therapeutic antibody with low monovalent affinity requires bivalent engagement. PMID:24743696
Molecular basis of the general base catalysis of an α/β-hydrolase catalytic triad. PMID:24737327
Redefining the PF06864 Pfam family based on Burkholderia pseudomallei PilO2(Bp) S-SAD crystal structure. PMID:24728008
Structure and catalytic regulatory function of ubiquitin specific protease 11 N-terminal and ubiquitin-like domains. PMID:24724799
The structured core domain of αB-crystallin can prevent amyloid fibrillation and associated toxicity. PMID:24711386
Molecular basis for AUXIN RESPONSE FACTOR protein interaction and the control of auxin response repression. PMID:24706860
Crystal structure of a 4-thiouridine synthetase-RNA complex reveals specificity of tRNA U8 modification. PMID:24705700
Structural basis of recognition of interferon-α receptor by tyrosine kinase 2. PMID:24704786
Structure of the Reston ebolavirus VP30 C-terminal domain. PMID:24699737
Structural characterization of a novel autonomous cohesin from Ruminococcus flavefaciens. PMID:24699736
Comparison of four different crystal forms of the Mycobacterium tuberculosis ESX-1 secreted protein regulator EspR. PMID:24699733
Structure of 4-pyridoxolactonase from Mesorhizobium loti. PMID:24699732
Partial rotational lattice order-disorder in stefin B crystals. PMID:24699646
Structural biology of the IL-1 superfamily: key cytokines in the regulation of immune and inflammatory responses. PMID:24677376
Molecular insights into the membrane-associated phosphatidylinositol 4-kinase IIα. PMID:24675427
The inner membrane complex sub-compartment proteins critical for replication of the apicomplexan parasite Toxoplasma gondii adopt a pleckstrin homology fold. PMID:24675080
Molecular basis for the fold organization and sarcomeric targeting of the muscle atrogin MuRF1. PMID:24671946
Discovery and characterization of olokizumab: a humanized antibody targeting interleukin-6 and neutralizing gp130-signaling. PMID:24670876
Esterase LpEst1 from Lactobacillus plantarum: a novel and atypical member of the αβ hydrolase superfamily of enzymes. PMID:24663330
The crystal structure of Giardia duodenalis 14-3-3 in the apo form: when protein post-translational modifications make the difference. PMID:24658679
Understanding molecular recognition of promiscuity of thermophilic methionine adenosyltransferase sMAT from Sulfolobus solfataricus. PMID:24649856
Crystallographic and glycan microarray analysis of human polyomavirus 9 VP1 identifies N-glycolyl neuraminic acid as a receptor candidate. PMID:24648448
Structure and computational analysis of a novel protein with metallopeptidase-like and circularly permuted winged-helix-turn-helix domains reveals a possible role in modified polysaccharide biosynthesis. PMID:24646163
De novo structure prediction of globular proteins aided by sequence variation-derived contacts. PMID:24637808
Structure of the carboxy-terminal domain of Mycobacterium tuberculosis CarD protein: an essential rRNA transcriptional regulator. PMID:24637748
Crystal structure of the 5hmC specific endonuclease PvuRts1I. PMID:24634440
Human immunoglobulin E flexes between acutely bent and extended conformations. PMID:24632569
Effects of protein engineering and rational mutagenesis on crystal lattice of single chain antibody fragments. PMID:24615866
Crystal structure of the vaccinia virus DNA polymerase holoenzyme subunit D4 in complex with the A20 N-terminal domain. PMID:24603707
Crystal structure of the herpesvirus inner tegument protein UL37 supports its essential role in control of viral trafficking. PMID:24599989
A range of Cℇ3-Cℇ4 interdomain angles in IgE Fc accommodate binding to its receptor CD23. PMID:24598915
Structural analysis of β-glucosidase mutants derived from a hyperthermophilic tetrameric structure. PMID:24598756
Multi-PAS domain-mediated protein oligomerization of PpsR from Rhodobacter sphaeroides. PMID:24598755
The structure of cytomegalovirus immune modulator UL141 highlights structural Ig-fold versatility for receptor binding. PMID:24598754
Structural characteristics of alkaline phosphatase from the moderately halophilic bacterium Halomonas sp. 593. PMID:24598750
Role of κ→λ light-chain constant-domain switch in the structure and functionality of A17 reactibody. PMID:24598740
Structural basis of Flavivirus NS1 assembly and antibody recognition. PMID:24594604
Molecular basis underlying histone H3 lysine-arginine methylation pattern readout by Spin/Ssty repeats of Spindlin1. PMID:24589551
Insights into the initiation of JC virus DNA replication derived from the crystal structure of the T-antigen origin binding domain. PMID:24586168
Crystal structure of the carbapenem intrinsic resistance protein CarG. PMID:24583229
Functions of crystallins in and out of lens: roles in elongated and post-mitotic cells. PMID:24582830
Sensor domain of histidine kinase KinB of Pseudomonas: a helix-swapped dimer. PMID:24573685
Mechanism of Tc toxin action revealed in molecular detail. PMID:24572368
Large-scale analysis of B-cell epitopes on influenza virus hemagglutinin - implications for cross-reactivity of neutralizing antibodies. PMID:24570677
Intradimer/Intermolecular interactions suggest autoinhibition mechanism in endophilin A1. PMID:24568626
Crystal structure and molecular imaging of the Nav channel β3 subunit indicates a trimeric assembly. PMID:24567321
The structural basis of an NADP⁺-independent dithiol oxidase in FK228 biosynthesis. PMID:24553401
Activating killer cell immunoglobulin-like receptor 2DS2 binds to HLA-A*11. PMID:24550293
The tripartite motif coiled-coil is an elongated antiparallel hairpin dimer. PMID:24550273
Exploring the atomic structure and conformational flexibility of a 320 Å long engineered viral fiber using X-ray crystallography. PMID:24531468
Structural analysis of the endogenous glycoallergen Hev b 2 (endo-β-1,3-glucanase) from Hevea brasiliensis and its recognition by human basophils. PMID:24531467
High-resolution structure of the M14-type cytosolic carboxypeptidase from Burkholderia cenocepacia refined exploiting PDB_REDO strategies. PMID:24531462
Structure of dihydromethanopterin reductase, a cubic protein cage for redox transfer. PMID:24523405
Structural stability of influenza A(H1N1)pdm09 virus hemagglutinins. PMID:24522930
Structural and functional analysis of MiD51, a dynamin receptor required for mitochondrial fission. PMID:24515348
Computational large-scale mapping of protein-protein interactions using structural complexes. PMID:24510594
Interactions and structural variability of β-carboxysomal shell protein CcmL. PMID:24504539
Structural characterization of MepB from Staphylococcus aureus reveals homology to endonucleases. PMID:24501097
Structural insights into the dimerization of the response regulator ComE from Streptococcus pneumoniae. PMID:24500202
Biochemical phenotype of a common disease-causing mutation and a possible therapeutic approach for the phosphomannomutase 2-associated disorder of glycosylation. PMID:24498599
Structural and functional characterization of cargo-binding sites on the μ4-subunit of adaptor protein complex 4. PMID:24498434
CorA is a copper repressible surface-associated copper(I)-binding protein produced in Methylomicrobium album BG8. PMID:24498370
BswR controls bacterial motility and biofilm formation in Pseudomonas aeruginosa through modulation of the small RNA rsmZ. PMID:24497189
DAXX co-folds with H3.3/H4 using high local stability conferred by the H3.3 variant recognition residues. PMID:24493739
Structural data on the periplasmic aldehyde oxidoreductase PaoABC from Escherichia coli: SAXS and preliminary X-ray crystallography analysis. PMID:24492481
Improving predictions of protein-protein interfaces by combining amino acid-specific classifiers based on structural and physicochemical descriptors with their weighted neighbor averages. PMID:24489849
Affinity improvement of a therapeutic antibody by structure-based computational design: generation of electrostatic interactions in the transition state stabilizes the antibody-antigen complex. PMID:24475232
Activation-triggered subunit exchange between CaMKII holoenzymes facilitates the spread of kinase activity. PMID:24473075
Stability-activity tradeoffs constrain the adaptive evolution of RubisCO. PMID:24469821
Neutralizing antibodies can initiate genome release from human enterovirus 71. PMID:24469789
A novel structural unit in the N-terminal region of filamins. PMID:24469451
Structural plasticity of the Semliki Forest virus glycome upon interspecies transmission. PMID:24467287
Structural basis of thermal stability of the tungsten cofactor synthesis protein MoaB from Pyrococcus furiosus. PMID:24465852
Structural asymmetry in the closed state of mitochondrial Hsp90 (TRAP1) supports a two-step ATP hydrolysis mechanism. PMID:24462206
Structures of complexes of a metal-independent glycosyltransferase GT6 from Bacteroides ovatus with UDP-N-acetylgalactosamine (UDP-GalNAc) and its hydrolysis products. PMID:24459149
Functional and structural characterization of Vibrio cholerae extracellular serine protease B, VesB. PMID:24459146
Deriving a mutation index of carcinogenicity using protein structure and protein interfaces. PMID:24454733
Metal binding properties of Escherichia coli YjiA, a member of the metal homeostasis-associated COG0523 family of GTPases. PMID:24449932
Targeting γ-herpesvirus 68 Bcl-2-mediated down-regulation of autophagy. PMID:24443581
Crystal structures of the human Dysferlin inner DysF domain. PMID:24438169
Crystal structure of the essential transcription antiterminator M2-1 protein of human respiratory syncytial virus and implications of its phosphorylation. PMID:24434552
Dimeric structure of p300/CBP associated factor. PMID:24423233
Red blood cell invasion by Plasmodium vivax: structural basis for DBP engagement of DARC. PMID:24415938
Electrostatic charge at position 552 affects the activation and permeation of FMRFamide-gated Na+ channels. PMID:24415456
Applying molecular crowding models to simulations of virus capsid assembly in vitro. PMID:24411263
Crystal structures of IspF from Plasmodium falciparum and Burkholderia cenocepacia: comparisons inform antimicrobial drug target assessment. PMID:24410837
SH2B1β interacts with STAT3 and enhances fibroblast growth factor 1-induced gene expression during neuronal differentiation. PMID:24396070
New mini- zincin structures provide a minimal scaffold for members of this metallopeptidase superfamily. PMID:24383880
The future of crystallography in drug discovery. PMID:24372145
Structural basis for the regulatory function of a complex zinc-binding domain in a replicative arterivirus helicase resembling a nonsense-mediated mRNA decay helicase. PMID:24369429
Conformational itinerary of Pseudomonas aeruginosa 1,6-anhydro-N-acetylmuramic acid kinase during its catalytic cycle. PMID:24362022
Structure and function of a novel cellulase 5 from sugarcane soil metagenome. PMID:24358302
From knock-out phenotype to three-dimensional structure of a promising antibiotic target from Streptococcus pneumoniae. PMID:24349508
Structural propensities of human ubiquitination sites: accessibility, centrality and local conformation. PMID:24349449
Structures of Wnt-antagonist ZNRF3 and its complex with R-spondin 1 and implications for signaling. PMID:24349440
Amino acid changes in disease-associated variants differ radically from variants observed in the 1000 genomes project dataset. PMID:24348229
Structural change in FtsZ Induced by intermolecular interactions between bound GTP and the T7 loop. PMID:24347164
Polymorphisms and interspecies differences of the activating and inhibitory FcγRII of Macaca nemestrina influence the binding of human IgG subclasses. PMID:24342805
Chronophin dimerization is required for proper positioning of its substrate specificity loop. PMID:24338687
Evolutionary and structural analyses of mammalian haloacid dehalogenase-type phosphatases AUM and chronophin provide insight into the basis of their different substrate specificities. PMID:24338473
Structural basis for HIV-1 neutralization by 2F5-like antibodies m66 and m66.6. PMID:24335316
Molecular evolution of protein-RNA mimicry as a mechanism for translational control. PMID:24335280
BioSuper: a web tool for the superimposition of biomolecules and assemblies with rotational symmetry. PMID:24330655
Crystal structures of the human G3BP1 NTF2-like domain visualize FxFG Nup repeat specificity. PMID:24324649
MMDB and VAST+: tracking structural similarities between macromolecular complexes. PMID:24319143
Two high-resolution structures of the human E3 ubiquitin ligase Siah1. PMID:24316825
PKA RIα homodimer structure reveals an intermolecular interface with implications for cooperative cAMP binding and Carney complex disease. PMID:24316401
Structure and self-assembly of the calcium binding matrix protein of human metapneumovirus. PMID:24316400
Heterologous expression of mycobacterial Esx complexes in Escherichia coli for structural studies is facilitated by the use of maltose binding protein fusions. PMID:24312350
The multidrug resistance IncA/C transferable plasmid encodes a novel domain-swapped dimeric protein-disulfide isomerase. PMID:24311786
Improvements in the order, isotropy and electron density of glypican-1 crystals by controlled dehydration. PMID:24311593
Structural basis for type VI secreted peptidoglycan DL-endopeptidase function, specificity and neutralization in Serratia marcescens. PMID:24311588
The landscape of cytokinin binding by a plant nodulin. PMID:24311578
A glutathione-independent glyoxalase of the DJ-1 superfamily plays an important role in managing metabolically generated methylglyoxal in Candida albicans. PMID:24302734
iPfam: a database of protein family and domain interactions found in the Protein Data Bank. PMID:24297255
Structure and function of the CSL-KyoT2 corepressor complex: a negative regulator of Notch signaling. PMID:24290140
PDBe: Protein Data Bank in Europe. PMID:24288376
Spot14/Mig12 heterocomplex sequesters polymerization and restrains catalytic function of human acetyl-CoA carboxylase 2. PMID:24277613
Crystal structures of the Toll/Interleukin-1 receptor (TIR) domains from the Brucella protein TcpB and host adaptor TIRAP reveal mechanisms of molecular mimicry. PMID:24275656
LUD, a new protein domain associated with lactate utilization. PMID:24274019
The active form of E6-associated protein (E6AP)/UBE3A ubiquitin ligase is an oligomer. PMID:24273172
Structure of human peptidyl-prolyl cis-trans isomerase FKBP22 containing two EF-hand motifs. PMID:24272907
Crystal structures of Trypanosoma brucei oligopeptidase B broaden the paradigm of catalytic regulation in prolyl oligopeptidase family enzymes. PMID:24265767
Mechanism of bacterial interference with TLR4 signaling by Brucella Toll/interleukin-1 receptor domain-containing protein TcpB. PMID:24265315
Formiminoglutamase from Trypanosoma cruzi is an arginase-like manganese metalloenzyme. PMID:24261485
X-ray crystal structure of the ancestral 3-ketosteroid receptor-progesterone-mifepristone complex shows mifepristone bound at the coactivator binding interface. PMID:24260475
Structure of the Proteus vulgaris HigB-(HigA)2-HigB toxin-antitoxin complex. PMID:24257752
Stabilization of the dimeric birch pollen allergen Bet v 1 impacts its immunological properties. PMID:24253036
Specialized Dynamical Properties of Promiscuous Residues Revealed by Simulated Conformational Ensembles. PMID:24250278
Filling out the structural map of the NTF2-like superfamily. PMID:24246060
Structure-based function prediction of uncharacterized protein using binding sites comparison. PMID:24244144
CtpB assembles a gated protease tunnel regulating cell-cell signaling during spore formation in Bacillus subtilis. PMID:24243021
The crystal structure of sterol carrier protein 2 from Yarrowia lipolytica and the evolutionary conservation of a large, non-specific lipid-binding cavity. PMID:24241823
Structural basis for recognition of synaptic vesicle protein 2C by botulinum neurotoxin A. PMID:24240280
Nucleotide-induced asymmetry within ATPase activator ring drives σ54-RNAP interaction and ATP hydrolysis. PMID:24240239
Structural and molecular basis of ZNRF3/RNF43 transmembrane ubiquitin ligase inhibition by the Wnt agonist R-spondin. PMID:24225776
Solution and crystallographic structures of the central region of the phosphoprotein from human metapneumovirus. PMID:24224051
Novel disulfide bond-mediated dimerization of the CARD domain was revealed by the crystal structure of CARMA1 CARD. PMID:24224005
Structural and enzymatic characterization of the phosphotriesterase OPHC2 from Pseudomonas pseudoalcaligenes. PMID:24223749
Discovery of protective B-cell epitopes for development of antimicrobial vaccines and antibody therapeutics. PMID:24219801
Structure and assembly of an inner membrane platform for initiation of type IV pilus biogenesis. PMID:24218553
Packing interface energetics in different crystal forms of the λ Cro dimer. PMID:24218107
Structural determinants of unique properties of human IgG4-Fc. PMID:24211234
The crystal structures of the tri-functional Chloroflexus aurantiacus and bi-functional Rhodobacter sphaeroides malyl-CoA lyases and comparison with CitE-like superfamily enzymes and malate synthases. PMID:24206647
Increasing affinity of interferon-γ receptor 1 to interferon-γ by computer-aided design. PMID:24199198
MP:PD--a data base of internal packing densities, internal packing defects and internal waters of helical membrane proteins. PMID:24194596
Structure of CT584 from Chlamydia trachomatis refined to 3.05 Å resolution. PMID:24192348
Crystal structure of a putative quorum sensing-regulated protein (PA3611) from the Pseudomonas-specific DUF4146 family. PMID:24174223
Role of the HIN domain in regulation of innate immune responses. PMID:24164899
The oligomeric state of the active Vps4 AAA ATPase. PMID:24161953
High-resolution crystal structure of the eukaryotic HMP-P synthase (THIC) from Arabidopsis thaliana. PMID:24161603
Crystal structure of the nipah virus phosphoprotein tetramerization domain. PMID:24155387
RNA polymerase I structure and transcription regulation. PMID:24153182
Comparative analysis of the Tyr-kinases CapB1 and CapB2 fused to their cognate modulators CapA1 and CapA2 from Staphylococcus aureus. PMID:24146800
Crystal structure of the gamma-2 herpesvirus LANA DNA binding domain identifies charged surface residues which impact viral latency. PMID:24146618
An analysis of oligomerization interfaces in transmembrane proteins. PMID:24134166
Structural insights into a novel interkingdom signaling circuit by cartography of the ligand-binding sites of the homologous quorum sensing LuxR-family. PMID:24132148
Crystal structure of the Psb28 accessory factor of Thermosynechococcus elongatus photosystem II at 2.3 Å. PMID:24126792
Structural and functional characterization of an orphan ATP-binding cassette ATPase involved in manganese utilization and tolerance in Leptospira spp. PMID:24123817
Structure and function of a novel LD-carboxypeptidase a involved in peptidoglycan recycling. PMID:24123814
Structural basis of mRNA recognition and cleavage by toxin MazF and its regulation by antitoxin MazE in Bacillus subtilis. PMID:24120662
Understanding specificity of the mycosin proteases in ESX/type VII secretion by structural and functional analysis. PMID:24113528
Antibacterial mechanisms identified through structural systems pharmacology. PMID:24112686
Structure of succinyl-CoA:3-ketoacid CoA transferase from Drosophila melanogaster. PMID:24100554
A monoclinic crystal form of casein kinase 1 δ. PMID:24100552
Rv2969c, essential for optimal growth in Mycobacterium tuberculosis, is a DsbA-like enzyme that interacts with VKOR-derived peptides and has atypical features of DsbA-like disulfide oxidases. PMID:24100317
Functional convergence of structurally distinct thioesterases from cyanobacteria and plants involved in phylloquinone biosynthesis. PMID:24100308
Structural insights into functional overlapping and differentiation among myosin V motors. PMID:24097982
Crystal and solution studies of the "Plus-C" odorant-binding protein 48 from Anopheles gambiae: control of binding specificity through three-dimensional domain swapping. PMID:24097978
Putative bioactive motif of tritrpticin revealed by an antibody with biological receptor-like properties. PMID:24086578
Structure of the factor VIII C2 domain in a ternary complex with 2 inhibitor antibodies reveals classical and nonclassical epitopes. PMID:24085769
Functional and structural study of the dimeric inner membrane protein SbmA. PMID:24078611
Matrix metalloproteinase-10/TIMP-2 structure and analyses define conserved core interactions and diverse exosite interactions in MMP/TIMP complexes. PMID:24073280
Cross-link guided molecular modeling with ROSETTA. PMID:24069194
Deep mutational scanning of an RRM domain of the Saccharomyces cerevisiae poly(A)-binding protein. PMID:24064791
Structures of a bifunctional cell wall hydrolase CwlT containing a novel bacterial lysozyme and an NlpC/P60 DL-endopeptidase. PMID:24051416
Novel insights into eukaryotic γ-glutamyltranspeptidase 1 from the crystal structure of the glutamate-bound human enzyme. PMID:24047895
Potential regulatory interactions of Escherichia coli RraA protein with DEAD-box helicases. PMID:24045937
The crystal structure of an extracellular catechol oxidase from the ascomycete fungus Aspergillus oryzae. PMID:24043469
Structure of the NheA component of the Nhe toxin from Bacillus cereus: implications for function. PMID:24040335
Tryptophan-accelerated electron flow across a protein-protein interface. PMID:24032375
An open conformation determined by a structural switch for 2A protease from coxsackievirus A16. PMID:24026848
The power of two: arginine 51 and arginine 239* from a neighboring subunit are essential for catalysis in α-amino-β-carboxymuconate-epsilon-semialdehyde decarboxylase. PMID:24019523
Crystal structure and substrate specificity of D-galactose-6-phosphate isomerase complexed with substrates. PMID:24015281
Selection of specific protein binders for pre-defined targets from an optimized library of artificial helicoidal repeat proteins (alphaRep). PMID:24014183
Structural insights into the functions of the FANCM-FAAP24 complex in DNA repair. PMID:24003026
Thermodynamic dissection of large-scale domain motions coupled with ligand binding of enzyme I. PMID:24002921
Analysis of the human cofilin 1 structure reveals conformational changes required for actin binding. PMID:23999301
Structural templates for modeling homodimers. PMID:23996787
The structure of amylosucrase from Deinococcus radiodurans has an unusual open active-site topology. PMID:23989143
Structure of formaldehyde dehydrogenase from Pseudomonas aeruginosa: the binary complex with the cofactor NAD+. PMID:23989142
Structure of isochorismate synthase DhbC from Bacillus anthracis. PMID:23989140
A large solvent isotope effect on protein association thermodynamics. PMID:23984950
Structural biology study of human TNF receptor associated factor 4 TRAF domain. PMID:23982741
Crystal structure of the DdrB/ssDNA complex from Deinococcus radiodurans reveals a DNA binding surface involving higher-order oligomeric states. PMID:23975200
Structural basis for Z-DNA binding and stabilization by the zebrafish Z-DNA dependent protein kinase PKZ. PMID:23975196
Structural and bioinformatic analysis of the kiwifruit allergen Act d 11, a member of the family of ripening-related proteins. PMID:23969108
Structural basis for the interaction of the adaptor protein grb14 with activated ras. PMID:23967305
A compact viral processing proteinase/ubiquitin hydrolase from the OTU family. PMID:23966860
Structure of the NS1 protein N-terminal origin recognition/nickase domain from the emerging human bocavirus. PMID:23966383
Biophysical analysis of the putative acetyltransferase SACOL2570 from methicillin-resistant Staphylococcus aureus. PMID:23963951
Structural basis for regulation of human glucokinase by glucokinase regulatory protein. PMID:23957911
The tip of the tail needle affects the rate of DNA delivery by bacteriophage P22. PMID:23951045
Toxoplasma gondii sporozoites invade host cells using two novel paralogues of RON2 and AMA1. PMID:23940612
A comparison of structural and evolutionary attributes of Escherichia coli and Thermus thermophilus small ribosomal subunits: signatures of thermal adaptation. PMID:23940533
Crystal structure of pim1 kinase in complex with a pyrido[4,3-d]pyrimidine derivative suggests a unique binding mode. PMID:23936194
Structure of the SCAN domain of human paternally expressed gene 3 protein. PMID:23936039
Conformational plasticity at the IgE-binding site of the B-cell receptor CD23. PMID:23933509
PAAR-repeat proteins sharpen and diversify the type VI secretion system spike. PMID:23925114
Structural basis of subtilase cytotoxin SubAB assembly. PMID:23921389
Crystal structures of isoorotate decarboxylases reveal a novel catalytic mechanism of 5-carboxyl-uracil decarboxylation and shed light on the search for DNA decarboxylase. PMID:23917530
Structural changes during cysteine desulfurase CsdA and sulfur acceptor CsdE interactions provide insight into the trans-persulfuration. PMID:23913692
The structure of substrate-free 1,5-anhydro-D-fructose reductase from Sinorhizobium meliloti 1021 reveals an open enzyme conformation. PMID:23908025
Calcium binding by the PKD1 domain regulates interdomain flexibility in Vibrio cholerae metalloprotease PrtV. PMID:23905008
Synthesis of α-glucan in mycobacteria involves a hetero-octameric complex of trehalose synthase TreS and Maltokinase Pep2. PMID:23901909
Structural insight into the evolution of a new chemokine family from zebrafish. PMID:23900850
Analysis of periplasmic sensor domains from Anaeromyxobacter dehalogenans 2CP-C: structure of one sensor domain from a histidine kinase and another from a chemotaxis protein. PMID:23897711
Crystal structure of the N-acetyltransferase domain of human N-acetyl-L-glutamate synthase in complex with N-acetyl-L-glutamate provides insights into its catalytic and regulatory mechanisms. PMID:23894642
Monovalent antibody design and mechanism of action of onartuzumab, a MET antagonist with anti-tumor activity as a therapeutic agent. PMID:23882082
A cyclic GMP-dependent signalling pathway regulates bacterial phytopathogenesis. PMID:23881098
Identification, structure, and function of a novel type VI secretion peptidoglycan glycoside hydrolase effector-immunity pair. PMID:23878199
DockRank: ranking docked conformations using partner-specific sequence homology-based protein interface prediction. PMID:23873600
Epitope mapping of metuximab on CD147 using phage display and molecular docking. PMID:23861727
The role of salt bridges, charge density, and subunit flexibility in determining disassembly routes of protein complexes. PMID:23850452
Structure of the archaeal Cascade subunit Csa5: relating the small subunits of CRISPR effector complexes. PMID:23846216
The mode of inhibitor binding to peptidyl-tRNA hydrolase: binding studies and structure determination of unbound and bound peptidyl-tRNA hydrolase from Acinetobacter baumannii. PMID:23844024
Heavy chain-only IgG2b llama antibody effects near-pan HIV-1 neutralization by recognizing a CD4-induced epitope that includes elements of coreceptor- and CD4-binding sites. PMID:23843638
Fungal effector Ecp6 outcompetes host immune receptor for chitin binding through intrachain LysM dimerization. PMID:23840930
Validated near-atomic resolution structure of bacteriophage epsilon15 derived from cryo-EM and modeling. PMID:23840063
Evolutionary diversification of the multimeric states of proteins. PMID:23836639
Personalized synthetic lethality induced by targeting RAD52 in leukemias identified by gene mutation and expression profile. PMID:23836560
Conformational stability and crystal packing: polymorphism in Neurospora crassa CAT-3. PMID:23832201
The compact conformation of the Plasmodium knowlesi myosin tail interacting protein MTIP in complex with the C-terminal helix of myosin A. PMID:23831369
Structure analysis of the extracellular domain reveals disulfide bond forming-protein properties of Mycobacterium tuberculosis Rv2969c. PMID:23828196
Structural Insights into the Effector - Immunity System Tae4/Tai4 from Salmonella typhimurium. PMID:23826277
DXP synthase-catalyzed C-N bond formation: nitroso substrate specificity studies guide selective inhibitor design. PMID:23824585
A dodecameric ring-like structure of the N0 domain of the type II secretin from enterotoxigenic Escherichia coli. PMID:23820381
Structural and functional analysis of the yeast N-acetyltransferase Mpr1 involved in oxidative stress tolerance via proline metabolism. PMID:23818613
Crystal structure of the N-terminal domain of EccA₁ ATPase from the ESX-1 secretion system of Mycobacterium tuberculosis. PMID:23818233
Crystal structure of peroxisomal targeting signal-2 bound to its receptor complex Pex7p-Pex21p. PMID:23812376
Crystal structures and biochemical studies of human lysophosphatidic acid phosphatase type 6. PMID:23807634
Substrate Channel Flexibility in Pseudomonas aeruginosa MurB Accommodates Two Distinct Substrates. PMID:23805286
Structural and biochemical studies of SLIP1-SLBP identify DBP5 and eIF3g as SLIP1-binding proteins. PMID:23804756
Unleashing the power of meta-threading for evolution/structure-based function inference of proteins. PMID:23802014
Biophysical characterization and crystal structure of the Feline Immunodeficiency Virus p15 matrix protein. PMID:23800358
INI1/hSNF5-interaction defective HIV-1 IN mutants exhibit impaired particle morphology, reverse transcription and integration in vivo. PMID:23799881
Cancer missense mutations alter binding properties of proteins and their interaction networks. PMID:23799087
Peptide-binding dependent conformational changes regulate the transcriptional activity of the quorum-sensor NprR. PMID:23793817
Crystal structure of a human IκB kinase β asymmetric dimer. PMID:23792959
Crystallographic study of multi-drug resistant HIV-1 protease lopinavir complex: mechanism of drug recognition and resistance. PMID:23792096
Knowledge-based design of a biosensor to quantify localized ERK activation in living cells. PMID:23790495
A structural modeling approach for the understanding of initiation and elongation of ALS-linked superoxide dismutase fibrils. PMID:23780345
Characterization of 14-3-3-ζ Interactions with integrin tails. PMID:23763993
Capsid antibodies to different adeno-associated virus serotypes bind common regions. PMID:23760240
Structure-guided optimization of protein kinase inhibitors reverses aminoglycoside antibiotic resistance. PMID:23758273
Structural and functional characterization of MppR, an enduracididine biosynthetic enzyme from streptomyces hygroscopicus: functional diversity in the acetoacetate decarboxylase-like superfamily. PMID:23758195
Structure, dynamics, and specificity of endoglucanase D from Clostridium cellulovorans. PMID:23751954
A structural basis for the regulation of the LIM-homeodomain protein islet 1 (Isl1) by intra- and intermolecular interactions. PMID:23750000
Structural determinants of oligomerization of δ(1)-pyrroline-5-carboxylate dehydrogenase: identification of a hexamerization hot spot. PMID:23747974
Crystal structure analysis of L-fuculose-1-phosphate aldolase from Thermus thermophilus HB8 and its catalytic action: as explained through in silico. PMID:23744484
Obstruction of dengue virus maturation by Fab fragments of the 2H2 antibody. PMID:23740974
An uncharacterized member of the ribokinase family in Thermococcus kodakarensis exhibits myo-inositol kinase activity. PMID:23737529
SPACER: Server for predicting allosteric communication and effects of regulation. PMID:23737445
The structure of the Mycobacterium smegmatis trehalose synthase reveals an unusual active site configuration and acarbose-binding mode. PMID:23735230
High-resolution structures of the IgM Fc domains reveal principles of its hexamer formation. PMID:23733956
Structure and function of an insect α-carboxylesterase (αEsterase7) associated with insecticide resistance. PMID:23733941
Crystal structure of a novel N-substituted L-amino acid dioxygenase from Burkholderia ambifaria AMMD. PMID:23724013
Further structural insights into the binding of complement factor H by complement regulator-acquiring surface protein 1 (CspA) of Borrelia burgdorferi. PMID:23722839
ErpC, a member of the complement regulator-acquiring family of surface proteins from Borrelia burgdorferi, possesses an architecture previously unseen in this protein family. PMID:23722838
Structure of PatF from Prochloron didemni. PMID:23722837
Structure of diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase from Acinetobacter baumannii. PMID:23722836
A triclinic crystal structure of the carboxy-terminal domain of HIV-1 capsid protein with four molecules in the asymmetric unit reveals a novel packing interface. PMID:23722834
Medicago truncatula histidine-containing phosphotransfer protein: structural and biochemical insights into the cytokinin transduction pathway in plants. PMID:23721763
Structural and functional basis for inhibition of erythrocyte invasion by antibodies that target Plasmodium falciparum EBA-175. PMID:23717209
Crystal structure of the FRP and identification of the active site for modulation of OCP-mediated photoprotection in cyanobacteria. PMID:23716688
A model of the membrane-bound cytochrome b5-cytochrome P450 complex from NMR and mutagenesis data. PMID:23709268
Structural basis for highly effective HIV-1 neutralization by CD4-mimetic miniproteins revealed by 1.5 Å cocrystal structure of gp120 and M48U1. PMID:23707685
In human pseudouridine synthase 1 (hPus1), a C-terminal helical insert blocks tRNA from binding in the same orientation as in the Pus1 bacterial homologue TruA, consistent with their different target selectivities. PMID:23707380
Structural basis for activity regulation and substrate preference of clostridial collagenases G, H, and T. PMID:23703618
Structural and mechanistic basis of anti-termination of Rho-dependent transcription termination by bacteriophage P4 capsid protein Psu. PMID:23703205
The nucleoprotein of severe fever with thrombocytopenia syndrome virus processes a stable hexameric ring to facilitate RNA encapsidation. PMID:23702688
The structure of the NTPase that powers DNA packaging into Sulfolobus turreted icosahedral virus 2. PMID:23698307
Structural basis of HCV neutralization by human monoclonal antibodies resistant to viral neutralization escape. PMID:23696737
Crystal structures of interleukin 17A and its complex with IL-17 receptor A. PMID:23695682
Expression, purification, crystallization and X-ray crystallographic studies of different redox states of the active site of thioredoxin 1 from the whiteleg shrimp Litopenaeus vannamei. PMID:23695560
S-Adenosyl-S-carboxymethyl-L-homocysteine: a novel cofactor found in the putative tRNA-modifying enzyme CmoA. PMID:23695253
Salmonella enterica MTAN at 1.36 Å resolution: a structure-based design of tailored transition state analogs. PMID:23685211
Ligand-dependent activation and deactivation of the human adenosine A(2A) receptor. PMID:23678995
N-terminal helix-cap in α-helix 2 modulates β-state misfolding in rabbit and hamster prion proteins. PMID:23675452
Structural insights into the UbiD protein family from the crystal structure of PA0254 from Pseudomonas aeruginosa. PMID:23671667
Crystal structure and functional insights into uracil-DNA glycosylase inhibition by phage Φ29 DNA mimic protein p56. PMID:23671337
Signal transduction pathways in the pentameric ligand-gated ion channels. PMID:23667707
The carboxy-terminal αN helix of the archaeal XerA tyrosine recombinase is a molecular switch to control site-specific recombination. PMID:23667562
Tetramerization reinforces the dimer interface of MnSOD. PMID:23667478
Evaluation and use of in-silico structure-based epitope prediction with foot-and-mouth disease virus. PMID:23667434
Crystal structures of Plasmodium falciparum cytosolic tryptophanyl-tRNA synthetase and its potential as a target for structure-guided drug design. PMID:23665145
Evolutionary, physicochemical, and functional mechanisms of protein homooligomerization. PMID:23663963
Structural basis of the induced-fit mechanism of 1,4-dihydroxy-2-naphthoyl coenzyme A synthase from the crotonase fold superfamily. PMID:23658663
Broadly neutralizing antibody PGT121 allosterically modulates CD4 binding via recognition of the HIV-1 gp120 V3 base and multiple surrounding glycans. PMID:23658524
Crystal structure of the avian astrovirus capsid spike. PMID:23658448
Structural basis for complement evasion by Lyme disease pathogen Borrelia burgdorferi. PMID:23658013
Structural analysis of collagen type I interactions with human fibronectin reveals a cooperative binding mode. PMID:23653354
Low-resolution structure of Drosophila translin. PMID:23650579
X-ray structure of an AdoMet radical activase reveals an anaerobic solution for formylglycine posttranslational modification. PMID:23650368
Phosphorylation-dependent conformational changes and domain rearrangements in Staphylococcus aureus VraR activation. PMID:23650349
Crystal structures of E. coli native MenH and two active site mutants. PMID:23637813
Cross-inhibition of chikungunya virus fusion and infection by alphavirus E1 domain III proteins. PMID:23637415
The role of structural bioinformatics resources in the era of integrative structural biology. PMID:23633580
Beta atomic contacts: identifying critical specific contacts in protein binding interfaces. PMID:23630569
Crystal structures of a plant trypsin inhibitor from Enterolobium contortisiliquum (EcTI) and of its complex with bovine trypsin. PMID:23626794
Structures of Mycobacterium tuberculosis FadD10 protein reveal a new type of adenylate-forming enzyme. PMID:23625916
Wzi is an outer membrane lectin that underpins group 1 capsule assembly in Escherichia coli. PMID:23623732
Bacteriophage P23-77 capsid protein structures reveal the archetype of an ancient branch from a major virus lineage. PMID:23623731
Structural and functional insights into Saccharomyces cerevisiae riboflavin biosynthesis reductase RIB7. PMID:23620735
Crystal structure of the protein from Arabidopsis thaliana gene At5g06450, a putative DnaQ-like exonuclease domain-containing protein with homohexameric assembly. PMID:23616405
Two crystal structures of Bombyx mori lipoprotein 3 - structural characterization of a new 30-kDa lipoprotein family member. PMID:23613829
Crystal structure of the capsular polysaccharide synthesizing protein CapE of Staphylococcus aureus. PMID:23611437
Crystal structure of human cytosolic aspartyl-tRNA synthetase, a component of multi-tRNA synthetase complex. PMID:23609930
The structure of glycerol trinitrate reductase NerA from Agrobacterium radiobacter reveals the molecular reason for nitro- and ene-reductase activity in OYE homologues. PMID:23606302
Structural and functional characterization of solute binding proteins for aromatic compounds derived from lignin: p-coumaric acid and related aromatic acids. PMID:23606130
Putative conformations of the receptor-binding domain in S protein of hCoV-EMC in complex with its receptor dipeptidyl peptidase-4. PMID:23603488
Structures of CD200/CD200 receptor family and implications for topology, regulation, and evolution. PMID:23602662
Nucleocapsid protein structures from orthobunyaviruses reveal insight into ribonucleoprotein architecture and RNA polymerization. PMID:23595147
A molecular switch governs the interaction between the human complement protease C1s and its substrate, complement C4. PMID:23592783
Crystal and solution studies reveal that the transcriptional regulator AcnR of Corynebacterium glutamicum is regulated by citrate-Mg2+ binding to a non-canonical pocket. PMID:23589369
Structural basis for phosphorylated autoinducer-2 modulation of the oligomerization state of the global transcription regulator LsrR from Escherichia coli. PMID:23589368
Structural basis for the enzymatic formation of the key strawberry flavor compound 4-hydroxy-2,5-dimethyl-3(2H)-furanone. PMID:23589283
Crystal structure of arginase from Leishmania mexicana and implications for the inhibition of polyamine biosynthesis in parasitic infections. PMID:23583962
Functional classification of immune regulatory proteins. PMID:23583034
Protein complexes are under evolutionary selection to assemble via ordered pathways. PMID:23582331
From soil to structure, a novel dimeric β-glucosidase belonging to glycoside hydrolase family 3 isolated from compost using metagenomic analysis. PMID:23580647
Structural and phylogenetic studies with MjTX-I reveal a multi-oligomeric toxin--a novel feature in Lys49-PLA2s protein class. PMID:23573271
Crystal structure of KLHL3 in complex with Cullin3. PMID:23573258
Structure and function of the DUF2233 domain in bacteria and in the human mannose 6-phosphate uncovering enzyme. PMID:23572527
New sub-family of lysozyme-like proteins shows no catalytic activity: crystallographic and biochemical study of STM3605 protein from Salmonella Typhimurium. PMID:23572252
Structure of the Leanyer orthobunyavirus nucleoprotein-RNA complex reveals unique architecture for RNA encapsidation. PMID:23569220
Structural characterization of Staphylococcus aureus biotin protein ligase and interaction partners: an antibiotic target. PMID:23559560
Co-evolution of a broadly neutralizing HIV-1 antibody and founder virus. PMID:23552890
Interaction of local anesthetics with the K (+) channel pore domain: KcsA as a model for drug-dependent tetramer stability. PMID:23545989
Structure of an atypical FeoB G-domain reveals a putative domain-swapped dimer. PMID:23545645
Deer mouse hemoglobin exhibits a lowered oxygen affinity owing to mobility of the E helix. PMID:23545644
Structure of glutaminyl cyclase from Drosophila melanogaster in space group I4. PMID:23545638
Organophosphorus acid anhydrolase from Alteromonas macleodii: structural study and functional relationship to prolidases. PMID:23545636
Biochemical characterization of molybdenum cofactor-free nitrate reductase from Neurospora crassa. PMID:23539622
Rational HIV immunogen design to target specific germline B cell receptors. PMID:23539181
Specificity of Processing α-glucosidase I is guided by the substrate conformation: crystallographic and in silico studies. PMID:23536181
The human ITPA polymorphic variant P32T is destabilized by the unpacking of the hydrophobic core. PMID:23528839
Structure of the tubulin/FtsZ-like protein TubZ from Pseudomonas bacteriophage ΦKZ. PMID:23528827
Self-assembly and conformational heterogeneity of the AXH domain of ataxin-1: an unusual example of a chameleon fold. PMID:23528090
Structure of a dimeric crenarchaeal Cas6 enzyme with an atypical active site for CRISPR RNA processing. PMID:23527601
Interaction and inhibition of dengue envelope glycoprotein with mammalian receptor DC-sign, an in-silico approach. PMID:23527139
Structural insights into putative molybdenum cofactor biosynthesis protein C (MoaC2) from Mycobacterium tuberculosis H37Rv. PMID:23526978
Intersubunit ionic interactions stabilize the nucleoside diphosphate kinase of Mycobacterium tuberculosis. PMID:23526954
Crystal structure of SsfS6, the putative C-glycosyltransferase involved in SF2575 biosynthesis. PMID:23526584
Structure of the flavoprotein tryptophan 2-monooxygenase, a key enzyme in the formation of galls in plants. PMID:23521653
Structure of Vibrio cholerae ribosome hibernation promoting factor. PMID:23519794
Structural characterization of V57D and V57P mutants of human cystatin C, an amyloidogenic protein. PMID:23519666
Protein-peptide complex crystallization: a case study on the ERK2 mitogen-activated protein kinase. PMID:23519423
GH1-family 6-P-β-glucosidases from human microbiome lactic acid bacteria. PMID:23519420
Structure of LdtMt2, an L,D-transpeptidase from Mycobacterium tuberculosis. PMID:23519418
Structural basis for the inhibition of Mycobacterium tuberculosis L,D-transpeptidase by meropenem, a drug effective against extensively drug-resistant strains. PMID:23519417
Structural basis for kinesin-1:cargo recognition. PMID:23519214
Kinetic and structural evidences on human prolidase pathological mutants suggest strategies for enzyme functional rescue. PMID:23516557
Structural and biochemical characterization of Plasmodium falciparum 12 (Pf12) reveals a unique interdomain organization and the potential for an antiparallel arrangement with Pf41. PMID:23511632
Structural basis for recognition of autophagic receptor NDP52 by the sugar receptor galectin-8. PMID:23511477
Crystal structures of the catalytic domain of human soluble guanylate cyclase. PMID:23505436
Functional site plasticity in domain superfamilies. PMID:23499848
The architecture of EssB, an integral membrane component of the type VII secretion system. PMID:23499020
Determination of the structure of the catabolic N-succinylornithine transaminase (AstC) from Escherichia coli. PMID:23484010
Kinetics of endophilin N-BAR domain dimerization and membrane interactions. PMID:23482561
Structural units important for activity of a novel-type phosphoserine phosphatase from Hydrogenobacter thermophilus TK-6 revealed by crystal structure analysis. PMID:23479726
Structure of the PolIIIα-τc-DNA complex suggests an atomic model of the replisome. PMID:23478062
Structural characterization of the self-association of the death domain of p75(NTR.). PMID:23472109
The AFF4 scaffold binds human P-TEFb adjacent to HIV Tat. PMID:23471103
Use of a molecular decoy to segregate transport from antigenicity in the FrpB iron transporter from Neisseria meningitidis. PMID:23457610
SOCS3 binds specific receptor-JAK complexes to control cytokine signaling by direct kinase inhibition. PMID:23454976
The TP0796 lipoprotein of Treponema pallidum is a bimetal-dependent FAD pyrophosphatase with a potential role in flavin homeostasis. PMID:23447540
The Deinococcus radiodurans DR1245 protein, a DdrB partner homologous to YbjN proteins and reminiscent of type III secretion system chaperones. PMID:23441204
Evolutionary and molecular analysis of the emergent severe fever with thrombocytopenia syndrome virus. PMID:23438426
Crystal structure of oligomeric β1-adrenergic G protein-coupled receptors in ligand-free basal state. PMID:23435379
Design of a superior cytokine antagonist for topical ophthalmic use. PMID:23431173
Three-dimensional structure of Saccharomyces invertase: role of a non-catalytic domain in oligomerization and substrate specificity. PMID:23430743
Dimerization of bacterial diaminopimelate epimerase is essential for catalysis. PMID:23426375
The switch helix: a putative combinatorial relay for interprotomer communication in cGMP-dependent protein kinase. PMID:23416533
Dramatic structural changes resulting from the loss of a crucial hydrogen bond in the hinge region involved in C-terminal helix swapping in SurE: a survival protein from Salmonella typhimurium. PMID:23409101
Structural and functional analysis of the CspB protease required for Clostridium spore germination. PMID:23408892
Structural basis for the recognition of tyrosine-based sorting signals by the μ3A subunit of the AP-3 adaptor complex. PMID:23404500
Structure of an actin-related subcomplex of the SWI/SNF chromatin remodeler. PMID:23401505
A recurring motif for antibody recognition of the receptor-binding site of influenza hemagglutinin. PMID:23396351
Structure-function relationships of two paralogous single-stranded DNA-binding proteins from Streptomyces coelicolor: implication of SsbB in chromosome segregation during sporulation. PMID:23393191
Evolution of crystallins for a role in the vertebrate eye lens. PMID:23389822
Quantitative characterization of the activation steps of mannan-binding lectin (MBL)-associated serine proteases (MASPs) points to the central role of MASP-1 in the initiation of the complement lectin pathway. PMID:23386610
The structure of the FnI-EGF-like tandem domain of coagulation factor XII solved using SIRAS. PMID:23385745
Structure of ALD1, a plant-specific homologue of the universal diaminopimelate aminotransferase enzyme of lysine biosynthesis. PMID:23385743
Structural and functional characterization of a noncanonical nucleoside triphosphate pyrophosphatase from Thermotoga maritima. PMID:23385455
A novel trans conformation of ligand-free calmodulin. PMID:23382982
Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins. PMID:23382219
IRAK-M mediates Toll-like receptor/IL-1R-induced NFκB activation and cytokine production. PMID:23376919
Regulation of protein-protein binding by coupling between phosphorylation and intrinsic disorder: analysis of human protein complexes. PMID:23364837
Crystal structure of IL-17 receptor B SEFIR domain. PMID:23355738
Structural, kinetic and computational investigation of Vitis vinifera DHDPS reveals new insight into the mechanism of lysine-mediated allosteric inhibition. PMID:23354837
Integron gene cassettes: a repository of novel protein folds with distinct interaction sites. PMID:23349695
Structural basis for Cul3 protein assembly with the BTB-Kelch family of E3 ubiquitin ligases. PMID:23349464
The molecular basis of iron-induced oligomerization of frataxin and the role of the ferroxidation reaction in oligomerization. PMID:23344952
Structure of ADP-aluminium fluoride-stabilized protochlorophyllide oxidoreductase complex. PMID:23341615
A structural basis for kinetochore recruitment of the Ndc80 complex via two distinct centromere receptors. PMID:23334295
The myosin chaperone UNC-45 is organized in tandem modules to support myofilament formation in C. elegans. PMID:23332754
Structural insight into DFMO resistant ornithine decarboxylase from Entamoeba histolytica: an inkling to adaptive evolution. PMID:23326423
Architecture and assembly of HIV integrase multimers in the absence of DNA substrates. PMID:23322775
Structure of the bifunctional acyltransferase/decarboxylase LnmK from the leinamycin biosynthetic pathway revealing novel activity for a double-hot-dog fold. PMID:23320975
Dimerization of Sir3 via its C-terminal winged helix domain is essential for yeast heterochromatin formation. PMID:23299941
Atomic structure of dual-specificity phosphatase 26, a novel p53 phosphatase. PMID:23298255
Structure of the Sgt2/Get5 complex provides insights into GET-mediated targeting of tail-anchored membrane proteins. PMID:23297211
The AEROPATH project targeting Pseudomonas aeruginosa: crystallographic studies for assessment of potential targets in early-stage drug discovery. PMID:23295481
Characterization of Anopheles gambiae transglutaminase 3 (AgTG3) and its native substrate Plugin. PMID:23288850
Crystal structure of an EAL domain in complex with reaction product 5'-pGpG. PMID:23285035
Structure of a VP1-VP3 complex suggests how birnaviruses package the VP1 polymerase. PMID:23283942
The structure of allophanate hydrolase from Granulibacter bethesdensis provides insights into substrate specificity in the amidase signature family. PMID:23282241
ACA-specific RNA sequence recognition is acquired via the loop 2 region of MazF mRNA interferase. PMID:23280569
Structural basis for the activation mechanism of the PlcR virulence regulator by the quorum-sensing signal peptide PapR. PMID:23277548
Evolution from the prokaryotic to the higher plant chloroplast signal recognition particle: the signal recognition particle RNA is conserved in plastids of a wide range of photosynthetic organisms. PMID:23275580
Structure of a C-terminal AHNAK peptide in a 1:2:2 complex with S100A10 and an acetylated N-terminal peptide of annexin A2. PMID:23275167
The unique structure of Haemophilus influenzae protein E reveals multiple binding sites for host factors. PMID:23275089
Conserved hydrogen bonds and water molecules in MDR HIV-1 protease substrate complexes. PMID:23261453
Protein interface classification by evolutionary analysis. PMID:23259833
Light-induced subunit dissociation by a light-oxygen-voltage domain photoreceptor from Rhodobacter sphaeroides. PMID:23252338
Crystal structure of rice importin-α and structural basis of its interaction with plant-specific nuclear localization signals. PMID:23250448
Outer domain of HIV-1 gp120: antigenic optimization, structural malleability, and crystal structure with antibody VRC-PG04. PMID:23236069
Structure of a dengue virus envelope protein late-stage fusion intermediate. PMID:23236058
On the binding affinity of macromolecular interactions: daring to ask why proteins interact. PMID:23235262
The structural basis of direct glucocorticoid-mediated transrepression. PMID:23222642
Antigenic switching of hepatitis B virus by alternative dimerization of the capsid protein. PMID:23219881
Architecture of the Atg17 complex as a scaffold for autophagosome biogenesis. PMID:23219485
Crystal structure of the hexachlorocyclohexane dehydrochlorinase (LinA-type2): mutational analysis, thermostability and enantioselectivity. PMID:23209726
PDBTM: Protein Data Bank of transmembrane proteins after 8 years. PMID:23203988
2P2Idb: a structural database dedicated to orthosteric modulation of protein-protein interactions. PMID:23203891
Structure of the human ATG12~ATG5 conjugate required for LC3 lipidation in autophagy. PMID:23202584
Structural basis of the interaction of MbtH-like proteins, putative regulators of nonribosomal peptide biosynthesis, with adenylating enzymes. PMID:23192349
ATP-dependent DNA ligase from Thermococcus sp. 1519 displays a new arrangement of the OB-fold domain. PMID:23192021
Structure of ribose 5-phosphate isomerase from the probiotic bacterium Lactobacillus salivarius UCC118. PMID:23192019
Impact of quaternary structure upon bacterial cytochrome c peroxidases: does homodimerization matter? PMID:23189923
Influence of structural symmetry on protein dynamics. PMID:23189176
The 2.5 Å structure of the enterococcus conjugation protein TraM resembles VirB8 type IV secretion proteins. PMID:23188825
Human C3a and C3a desArg anaphylatoxins have conserved structures, in contrast to C5a and C5a desArg. PMID:23184394
Crystal structure of the small GTPase Arl6/BBS3 from Trypanosoma brucei. PMID:23184293
Structure, phosphorylation and U2AF65 binding of the N-terminal domain of splicing factor 1 during 3'-splice site recognition. PMID:23175611
Babesia divergens and Neospora caninum apical membrane antigen 1 structures reveal selectivity and plasticity in apicomplexan parasite host cell invasion. PMID:23169033
Structural insight into inhibitor of apoptosis proteins recognition by a potent divalent smac-mimetic. PMID:23166698
The crystal structure of Arabidopsis VSP1 reveals the plant class C-like phosphatase structure of the DDDD superfamily of phosphohydrolases. PMID:23166664
A broad specificity nucleoside kinase from Thermoplasma acidophilum. PMID:23161756
Dimeric structure of the N-terminal domain of PriB protein from Thermoanaerobacter tengcongensis solved ab initio. PMID:23151633
Broad and potent neutralization of HIV-1 by a gp41-specific human antibody. PMID:23151583
The first structure of polarity suppression protein, Psu from enterobacteria phage P4, reveals a novel fold and a knotted dimer. PMID:23150672
The polybasic insertion in autotaxin α confers specific binding to heparin and cell surface heparan sulfate proteoglycans. PMID:23150666
An ultra-specific avian antibody to phosphorylated tau protein reveals a unique mechanism for phosphoepitope recognition. PMID:23148212
Characterization of Arabidopsis FPS isozymes and FPS gene expression analysis provide insight into the biosynthesis of isoprenoid precursors in seeds. PMID:23145086
Structural insight into the Clostridium difficile ethanolamine utilisation microcompartment. PMID:23144756
Influence of intermolecular contacts on the structure of recombinant prolidase from Thermococcus sibiricus. PMID:23143231
Structures of the Sgt2/SGTA dimerization domain with the Get5/UBL4A UBL domain reveal an interaction that forms a conserved dynamic interface. PMID:23142665
Molecular interaction analysis of cigarette smoke carcinogens NNK and NNAL with enzymes involved in DNA repair pathways: An in silico approach. PMID:23139587
Structure of the Trypanosoma cruzi protein tyrosine phosphatase TcPTP1, a potential therapeutic target for Chagas' disease. PMID:23137716
Crystal structure of an indole-3-acetic acid amido synthetase from grapevine involved in auxin homeostasis. PMID:23136372
Structure of a force-conveying cadherin bond essential for inner-ear mechanotransduction. PMID:23135401
Furin-cleaved proprotein convertase subtilisin/kexin type 9 (PCSK9) is active and modulates low density lipoprotein receptor and serum cholesterol levels. PMID:23135270
Inhibiting the protein ubiquitination cascade by ubiquitin-mimicking short peptides. PMID:23134251
Structure and mechanism of the polynucleotide kinase component of the bacterial Pnkp-Hen1 RNA repair system. PMID:23118415
Novel Clostridium thermocellum type I cohesin-dockerin complexes reveal a single binding mode. PMID:23118225
The native GCN4 leucine-zipper domain does not uniquely specify a dimeric oligomerization state. PMID:23116373
Structure of the St. Louis encephalitis virus postfusion envelope trimer. PMID:23115296
The metagenome-derived enzymes LipS and LipT increase the diversity of known lipases. PMID:23112831
Crystal structure of calmodulin binding domain of orai1 in complex with Ca2+ calmodulin displays a unique binding mode. PMID:23109337
Mechanistic and structural insight into the functional dichotomy between IL-2 and IL-15. PMID:23104097
The binding of Varp to VAMP7 traps VAMP7 in a closed, fusogenically inactive conformation. PMID:23104059
Neuropilins lock secreted semaphorins onto plexins in a ternary signaling complex. PMID:23104057
Crystal structure of the dimeric coiled-coil domain of the cytosolic nucleic acid sensor LRRFIP1. PMID:23099021
Biochemical properties and crystal structure of a β-phenylalanine aminotransferase from Variovorax paradoxus. PMID:23087034
Structural basis of bacterial defense against g-type lysozyme-based innate immunity. PMID:23086131
A novel mechanism of ligand binding and release in the odorant binding protein 20 from the malaria mosquito Anopheles gambiae. PMID:23081820
A green fluorescent protein containing a QFG tri-peptide chromophore: optical properties and X-ray crystal structure. PMID:23071789
Crystal structure of the human PRMT5:MEP50 complex. PMID:23071334
Two structures of a thiazolinyl imine reductase from Yersinia enterocolitica provide insight into catalysis and binding to the nonribosomal peptide synthetase module of HMWP1. PMID:23066849
Multiple binding sites on the pyrin domain of ASC protein allow self-association and interaction with NLRP3 protein. PMID:23066025
The structural biochemistry of Zucchini implicates it as a nuclease in piRNA biogenesis. PMID:23064227
The crystal structures of the α-subunit of the α(2)β (2) tetrameric Glycyl-tRNA synthetase. PMID:23054484
The last piece in the vitamin B1 biosynthesis puzzle: structural and functional insight into yeast 4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate (HMP-P) synthase. PMID:23048037
Structural insights into activation of antiviral NK cell responses. PMID:23046134
LpxI structures reveal how a lipid A precursor is synthesized. PMID:23042606
RANKL employs distinct binding modes to engage RANK and the osteoprotegerin decoy receptor. PMID:23039992
Competition between anion binding and dimerization modulates Staphylococcus aureus phosphatidylinositol-specific phospholipase C enzymatic activity. PMID:23038258
Structural and mechanistic investigations on Salmonella typhimurium acetate kinase (AckA): identification of a putative ligand binding pocket at the dimeric interface. PMID:23031654
High-resolution structures of Thermus thermophilus enoyl-acyl carrier protein reductase in the apo form, in complex with NAD+ and in complex with NAD+ and triclosan. PMID:23027736
Chemical and structural analysis of an antibody folding intermediate trapped during glycan biosynthesis. PMID:23025485
Crystal structure of the Klebsiella pneumoniae NFeoB/FeoC complex and roles of FeoC in regulation of Fe2+ transport by the bacterial Feo system. PMID:23024345
Structure-based prediction of protein-protein interactions on a genome-wide scale. PMID:23023127
The crystal structure of the Rv0301-Rv0300 VapBC-3 toxin-antitoxin complex from M. tuberculosis reveals a Mg²⁺ ion in the active site and a putative RNA-binding site. PMID:23011806
Characterization of a Phanerochaete chrysosporium glutathione transferase reveals a novel structural and functional class with ligandin properties. PMID:23007392
Crystal structure of mouse RhoA:GTPγS complex in a centered lattice. PMID:23001747
Crystal structure of the yeast vacuolar ATPase heterotrimeric EGC(head) peripheral stalk complex. PMID:23000382
Toward a hepatitis C virus vaccine: the structural basis of hepatitis C virus neutralization by AP33, a broadly neutralizing antibody. PMID:22993159
Crystallization, dehydration and experimental phasing of WbdD, a bifunctional kinase and methyltransferase from Escherichia coli O9a. PMID:22993091
Assessing the range of kinase autoinhibition mechanisms in the insulin receptor family. PMID:22992069
The substrate/product-binding modes of a novel GH120 β-xylosidase (XylC) from Thermoanaerobacterium saccharolyticum JW/SL-YS485. PMID:22992047
Solution NMR structure of the Ca2+-bound N-terminal domain of CaBP7: a regulator of golgi trafficking. PMID:22989873
Distinct regions of the Pseudomonas syringae coiled-coil effector AvrRps4 are required for activation of immunity. PMID:22988101
Structure of a novel winged-helix like domain from human NFRKB protein. PMID:22984442
Structural analysis of the quaking homodimerization interface. PMID:22982292
The crystal structure of the intact E. coli RelBE toxin-antitoxin complex provides the structural basis for conditional cooperativity. PMID:22981948
The extracellular protein factor Epf from Streptococcus pyogenes is a cell surface adhesin that binds to cells through an N-terminal domain containing a carbohydrate-binding module. PMID:22977243
Structural and functional characterization of VanG D-Ala:D-Ser ligase associated with vancomycin resistance in Enterococcus faecalis. PMID:22969085
Prediction of phenotypes of missense mutations in human proteins from biological assemblies. PMID:22965855
High affinity peptide inhibitors of the hepatitis C virus NS3-4A protease refractory to common resistant mutants. PMID:22965230
New secreted toxins and immunity proteins encoded within the Type VI secretion system gene cluster of Serratia marcescens. PMID:22957938
Insights into phosphate cooperativity and influence of substrate modifications on binding and catalysis of hexameric purine nucleoside phosphorylases. PMID:22957058
Structures of human DPP7 reveal the molecular basis of specific inhibition and the architectural diversity of proline-specific peptidases. PMID:22952628
The structure of the yeast NADH dehydrogenase (Ndi1) reveals overlapping binding sites for water- and lipid-soluble substrates. PMID:22949654
Structure of anabolic ornithine carbamoyltransferase from Campylobacter jejuni at 2.7 Å resolution. PMID:22949186
Structure of a UDP-glucose dehydrogenase from the hyperthermophilic archaeon Pyrobaculum islandicum. PMID:22949183
Structure of the Archaeoglobus fulgidus orphan ORF AF1382 determined by sulfur SAD from a moderately diffracting crystal. PMID:22948926
Structure of the prolyl-tRNA synthetase from the eukaryotic pathogen Giardia lamblia. PMID:22948920
Assignment of protein sequences to existing domain and family classification systems: Pfam and the PDB. PMID:22942020
Structural basis for RNA-duplex recognition and unwinding by the DEAD-box helicase Mss116p. PMID:22940866
The crystal structures of the tryparedoxin-tryparedoxin peroxidase couple unveil the structural determinants of Leishmania detoxification pathway. PMID:22928053
Structure of the haptoglobin-haemoglobin complex. PMID:22922649
Structural basis for ASPP2 recognition by the tumor suppressor p73. PMID:22917970
The crystal structures of dystrophin and utrophin spectrin repeats: implications for domain boundaries. PMID:22911693
Mutational and structural analysis of L-N-carbamoylase reveals new insights into a peptidase M20/M25/M40 family member. PMID:22904279
Explorations of linked editosome domains leading to the discovery of motifs defining conserved pockets in editosome OB-folds. PMID:22902563
Crystal structure of the VgrG1 actin cross-linking domain of the Vibrio cholerae type VI secretion system. PMID:22898822
Inhibition of Yersinia pestis DNA adenine methyltransferase in vitro by a stibonic acid compound: identification of a potential novel class of antimicrobial agents. PMID:22889062
Engineered variants of InlB with an additional leucine-rich repeat discriminate between physiologically relevant and packing contacts in crystal structures of the InlB:MET complex. PMID:22887347
Dynamic features of homodimer interfaces calculated by normal-mode analysis. PMID:22887034
The "CPC clip motif": a conserved structural signature for heparin-binding proteins. PMID:22880084
Structure of a specialized acyl carrier protein essential for lipid A biosynthesis with very long-chain fatty acids in open and closed conformations. PMID:22876860
13C NMR reveals no evidence of n-π* interactions in proteins. PMID:22876300
Alternative protein-protein interfaces are frequent exceptions. PMID:22876170
Structural basis for paxillin binding and focal adhesion targeting of β-parvin. PMID:22869380
Crystallization and preliminary X-ray diffraction analysis of three myotoxic phospholipases A2 from Bothrops brazili venom. PMID:22869126
A new crystal form of human histidine triad nucleotide-binding protein 1 (hHINT1) in complex with adenosine 5'-monophosphate at 1.38 Å resolution. PMID:22869114
Structural and biochemical characterization of a trapped coenzyme A adduct of Caenorhabditis elegans glucosamine-6-phosphate N-acetyltransferase 1. PMID:22868768
Structures of apo and product-bound human L-asparaginase: insights into the mechanism of autoproteolysis and substrate hydrolysis. PMID:22861376
Atypical reactive center Kunitz-type inhibitor from the sea anemone Heteractis crispa. PMID:22851925
Hydroxynitrile lyases with α/β-hydrolase fold: two enzymes with almost identical 3D structures but opposite enantioselectivities and different reaction mechanisms. PMID:22851196
Structural basis for morpheein-type allosteric regulation of Escherichia coli glucosamine-6-phosphate synthase: equilibrium between inactive hexamer and active dimer. PMID:22851174
A stomatin dimer modulates the activity of acid-sensing ion channels. PMID:22850675
Crystal structure of the Sema-PSI extracellular domain of human RON receptor tyrosine kinase. PMID:22848655
Analysis of domain-swapped oligomers reveals local sequence preferences and structural imprints at the linker regions and swapped interfaces. PMID:22848353
Interactions of isolated C-terminal fragments of neural Wiskott-Aldrich syndrome protein (N-WASP) with actin and Arp2/3 complex. PMID:22847007
Crystal structure of a monomeric thiolase-like protein type 1 (TLP1) from Mycobacterium smegmatis. PMID:22844533
Structural and functional analysis of phosphorylation-specific binders of the kinase ERK from designed ankyrin repeat protein libraries. PMID:22843676
Structure of a RING E3 ligase and ubiquitin-loaded E2 primed for catalysis. PMID:22842904
Getting personalized cancer genome analysis into the clinic: the challenges in bioinformatics. PMID:22839973
Crystal structure of ISG54 reveals a novel RNA binding structure and potential functional mechanisms. PMID:22825553
Structural and functional characterization of NikO, an enolpyruvyl transferase essential in nikkomycin biosynthesis. PMID:22810238
Structure and mechanism of human UDP-xylose synthase: evidence for a promoting role of sugar ring distortion in a three-step catalytic conversion of UDP-glucuronic acid. PMID:22810237
Structures of the PelD cyclic diguanylate effector involved in pellicle formation in Pseudomonas aeruginosa PAO1. PMID:22810222
Crystal structure of the conserved domain of the DC lysosomal associated membrane protein: implications for the lysosomal glycocalyx. PMID:22809326
Ipomoelin, a jacalin-related lectin with a compact tetrameric association and versatile carbohydrate binding properties regulated by its N terminus. PMID:22808208
X-ray crystal structure of the streptococcal specific phage lysin PlyC. PMID:22807482
The cloning, expression, purification, characterization and modeled structure of Caulobacter crescentus β-Xylosidase I. PMID:22806729
Integrative structural modeling with small angle X-ray scattering profiles. PMID:22800408
Structural insights into the effector-immunity system Tse1/Tsi1 from Pseudomonas aeruginosa. PMID:22792331
Characterisation of the first enzymes committed to lysine biosynthesis in Arabidopsis thaliana. PMID:22792278
Quality control of disulfide bond formation in pilus subunits by the chaperone FimC. PMID:22772153
Assembling of AcrB trimer in cell membrane. PMID:22766312
Crystal, solution and in silico structural studies of dihydrodipicolinate synthase from the common grapevine. PMID:22761676
Structure of the surface layer of the methanogenic archaean Methanosarcina acetivorans. PMID:22753492
Structural insights into the regulatory mechanism of the response regulator RocR from Pseudomonas aeruginosa in cyclic Di-GMP signaling. PMID:22753070
Structure of the signal transduction protein TRAP (target of RNAIII-activating protein). PMID:22750855
Structure of Leishmania major cysteine synthase. PMID:22750854
Structure of the regulatory domain of the LysR family regulator NMB2055 (MetR-like protein) from Neisseria meningitidis. PMID:22750853
Structural determinants of the β-selectivity of a bacterial aminotransferase. PMID:22745123
The structural basis for the sensing and binding of cyclic di-GMP by STING. PMID:22728659
Structure of the nuclear factor κB-inducing kinase (NIK) kinase domain reveals a constitutively active conformation. PMID:22718757
Protein camouflage in cytochrome c-calixarene complexes. PMID:22717436
Structural study of TTR-52 reveals the mechanism by which a bridging molecule mediates apoptotic cell engulfment. PMID:22713871
Crystal structure of the Yersinia enterocolitica type III secretion chaperone SycD in complex with a peptide of the minor translocator YopD. PMID:22708907
Crystal structure of the N-terminal domain of the yeast general corepressor Tup1p and its functional implications. PMID:22707714
Structural characterization of a conserved, calcium-dependent periplasmic protease from Legionella pneumophila. PMID:22707706
Structural basis of evasion of cellular adaptive immunity by HIV-1 Nef. PMID:22705789
Structure of the catalytic chain of Methanococcus jannaschii aspartate transcarbamoylase in a hexagonal crystal form: insights into the path of carbamoyl phosphate to the active site of the enzyme. PMID:22691781
The structure of an orthorhombic crystal form of a 'forced reduced' thiol peroxidase reveals lattice formation aided by the presence of the affinity tag. PMID:22691780
The molecular basis of ubiquitin-like protein NEDD8 deamidation by the bacterial effector protein Cif. PMID:22691497
Biochemical identification and crystal structure of kynurenine formamidase from Drosophila melanogaster. PMID:22690733
Structure of a short-chain dehydrogenase/reductase from Bacillus anthracis. PMID:22684058
Structural basis for membrane binding specificity of the Bin/Amphiphysin/Rvs (BAR) domain of Arfaptin-2 determined by Arl1 GTPase. PMID:22679020
Structural mechanism of ATP-induced polymerization of the partition factor ParF: implications for DNA segregation. PMID:22674577
Alternaria alternata allergen Alt a 1: a unique β-barrel protein dimer found exclusively in fungi. PMID:22664167
Crystal structures of the outer membrane domain of intimin and invasin from enterohemorrhagic E. coli and enteropathogenic Y. pseudotuberculosis. PMID:22658748
Computational design of self-assembling protein nanomaterials with atomic level accuracy. PMID:22654060
Structural basis of Wnt recognition by Frizzled. PMID:22653731
Crystal structures of Trypanosoma cruzi UDP-galactopyranose mutase implicate flexibility of the histidine loop in enzyme activation. PMID:22646091
Structure of the receptor-binding carboxy-terminal domain of bacteriophage T7 tail fibers. PMID:22645347
Molecular simulation and docking studies of Gal1p and Gal3p proteins in the presence and absence of ligands ATP and galactose: implication for transcriptional activation of GAL genes. PMID:22639079
Dissecting heterogeneous molecular chaperone complexes using a mass spectrum deconvolution approach. PMID:22633411
Interaction of Rio1 kinase with toyocamycin reveals a conformational switch that controls oligomeric state and catalytic activity. PMID:22629386
Extent of structural asymmetry in homodimeric proteins: prevalence and relevance. PMID:22629324
Quantitative analysis of prenylated RhoA interaction with its chaperone, RhoGDI. PMID:22628549
Design of meningococcal factor H binding protein mutant vaccines that do not bind human complement factor H. PMID:22615247
Structural basis for modification of flavonol and naphthol glucoconjugates by Nicotiana tabacum malonyltransferase (NtMaT1). PMID:22610270
Structure of the cytoplasmic region of PelD, a degenerate diguanylate cyclase receptor that regulates exopolysaccharide production in Pseudomonas aeruginosa. PMID:22605337
Mapping a neutralizing epitope onto the capsid of adeno-associated virus serotype 8. PMID:22593150
Large-scale experimental studies show unexpected amino acid effects on protein expression and solubility in vivo in E. coli. PMID:22587847
Structural analysis of the STING adaptor protein reveals a hydrophobic dimer interface and mode of cyclic di-GMP binding. PMID:22579474
Structural basis for small G protein effector interaction of Ras-related protein 1 (Rap1) and adaptor protein Krev interaction trapped 1 (KRIT1). PMID:22577140
FolX from Pseudomonas aeruginosa is octameric in both crystal and solution. PMID:22575651
Structural and mutational studies on substrate specificity and catalysis of Salmonella typhimurium D-cysteine desulfhydrase. PMID:22574144
Structure of a calcium-dependent 11R-lipoxygenase suggests a mechanism for Ca2+ regulation. PMID:22573333
Structural studies on molecular interactions between camel peptidoglycan recognition protein, CPGRP-S, and peptidoglycan moieties N-acetylglucosamine and N-acetylmuramic acid. PMID:22573327
The structure of the C-terminal domain of the largest editosome interaction protein and its role in promoting RNA binding by RNA-editing ligase L2. PMID:22561373
Linking yeast Gcn5p catalytic function and gene regulation using a quantitative, graded dominant mutant approach. PMID:22558379
Comparison of tertiary structures of proteins in protein-protein complexes with unbound forms suggests prevalence of allostery in signalling proteins. PMID:22554255
Structural characterization of binding mode of smoking cessation drugs to nicotinic acetylcholine receptors through study of ligand complexes with acetylcholine-binding protein. PMID:22553201
Structural insights into the conformation and oligomerization of E2~ubiquitin conjugates. PMID:22551455
Biochemical and structural characterization of the Arabidopsis bifunctional enzyme dethiobiotin synthetase-diaminopelargonic acid aminotransferase: evidence for substrate channeling in biotin synthesis. PMID:22547782
M. tuberculosis sliding β-clamp does not interact directly with the NAD+-dependent DNA ligase. PMID:22545130
Structural and biochemical studies of the open state of Lys48-linked diubiquitin. PMID:22542781
CONS-COCOMAPS: a novel tool to measure and visualize the conservation of inter-residue contacts in multiple docking solutions. PMID:22536965
Insight on an arginine synthesis metabolon from the tetrameric structure of yeast acetylglutamate kinase. PMID:22529931
Crystal structures of Xanthomonas campestris OleA reveal features that promote head-to-head condensation of two long-chain fatty acids. PMID:22524624
Structural basis of the intracellular sorting of the SNARE VAMP7 by the AP3 adaptor complex. PMID:22521722
Structural and functional characterization of microcin C resistance peptidase MccF from Bacillus anthracis. PMID:22516613
Conservation of oxidative protein stabilization in an insect homologue of parkinsonism-associated protein DJ-1. PMID:22515803
Mining genomes of marine cyanobacteria for elements of zinc homeostasis. PMID:22514551
Non-agonistic bivalent antibodies that promote c-MET degradation and inhibit tumor growth and others specific for tumor related c-MET. PMID:22511956
Monospecific inhibitors show that both mannan-binding lectin-associated serine protease-1 (MASP-1) and -2 Are essential for lectin pathway activation and reveal structural plasticity of MASP-2. PMID:22511776
Structural basis of heparin binding to camel peptidoglycan recognition protein-S. PMID:22509483
Crystal structure of Escherichia coli diaminopropionate ammonia-lyase reveals mechanism of enzyme activation and catalysis. PMID:22505717
In praise of impurity: 30S ribosomal S15 protein-assisted crystallization of turnip yellow mosaic virus proteinase. PMID:22505427
A glutathione transferase from Agrobacterium tumefaciens reveals a novel class of bacterial GST superfamily. PMID:22496785
Invariant gly residue is important for α-defensin folding, dimerization, and function: a case study of the human neutrophil α-defensin HNP1. PMID:22496447
Structural analysis of a dengue cross-reactive antibody complexed with envelope domain III reveals the molecular basis of cross-reactivity. PMID:22491255
Crystal structures of Aureochrome1 LOV suggest new design strategies for optogenetics. PMID:22483116
Crystal structure of Streptococcus pyogenes Csn2 reveals calcium-dependent conformational changes in its tertiary and quaternary structure. PMID:22479393
A novel dimerization interface of cyclic nucleotide binding domain, which is disrupted in presence of cAMP: implications for CNG channels gating. PMID:22476580
Detection of KCNJ11 gene mutations in a family with neonatal diabetes mellitus: implications for therapeutic management of family members with long-standing disease. PMID:22471336
Structure of 2-methylisoborneol synthase from Streptomyces coelicolor and implications for the cyclization of a noncanonical C-methylated monoterpenoid substrate. PMID:22455514
Structure of geranyl diphosphate C-methyltransferase from Streptomyces coelicolor and implications for the mechanism of isoprenoid modification. PMID:22455498
Progressive dry-core-wet-rim hydration trend in a nested-ring topology of protein binding interfaces. PMID:22452998
Roles of residues in the interface of transient protein-protein complexes before complexation. PMID:22451863
fSUB: normal mode analysis with flexible substructures. PMID:22448847
Extra-domain B in oncofetal fibronectin structurally promotes fibrillar head-to-tail dimerization of extracellular matrix protein. PMID:22442152
Structural characterization of closely related O-antigen lipopolysaccharide (LPS) chain length regulators. PMID:22437828
Mapping ultra-weak protein-protein interactions between heme transporters of Staphylococcus aureus. PMID:22427659
Matrix metalloproteinase-10 (MMP-10) interaction with tissue inhibitors of metalloproteinases TIMP-1 and TIMP-2: binding studies and crystal structure. PMID:22427646
Structure of the heterodimer of human NONO and paraspeckle protein component 1 and analysis of its role in subnuclear body formation. PMID:22416126
Functional and structural characterization of a thermostable acetyl esterase from Thermotoga maritima. PMID:22411095
Crystal structures of putative phosphoglycerate kinases from B. anthracis and C. jejuni. PMID:22403005
The 2.8 Å crystal structure of the dynein motor domain. PMID:22398446
Macro-to-micro structural proteomics: native source proteins for high-throughput crystallization. PMID:22393408
Structural characterisation of Tpx from Yersinia pseudotuberculosis reveals insights into the binding of salicylidene acylhydrazide compounds. PMID:22384182
Structural characterization and oligomerization of the TssL protein, a component shared by bacterial type VI and type IVb secretion systems. PMID:22371492
Low-resolution molecular models reveal the oligomeric state of the PPAR and the conformational organization of its domains in solution. PMID:22363753
Structural view of a non Pfam singleton and crystal packing analysis. PMID:22363703
New insight into the transcarbamylase family: the structure of putrescine transcarbamylase, a key catalyst for fermentative utilization of agmatine. PMID:22363663
Structure of Salmonella effector protein SopB N-terminal domain in complex with host Rho GTPase Cdc42. PMID:22362774
Inhibiting alternative pathway complement activation by targeting the factor D exosite. PMID:22362762
Tetrahydrodipicolinate N-succinyltransferase and dihydrodipicolinate synthase from Pseudomonas aeruginosa: structure analysis and gene deletion. PMID:22359568
Insights into substrate specificity and metal activation of mammalian tetrahedral aspartyl aminopeptidase. PMID:22356908
Stability of domain structures in multi-domain proteins. PMID:22355559
Crystal structure of N-glycosylated human glypican-1 core protein: structure of two loops evolutionarily conserved in vertebrate glypican-1. PMID:22351761
Crystal structure of a putative isochorismatase hydrolase from Oleispira antarctica. PMID:22350524
High-resolution structures of complexes of plant S-adenosyl-L-homocysteine hydrolase (Lupinus luteus). PMID:22349223
Structure of the cytoplasmic domain of Yersinia pestis YscD, an essential component of the type III secretion system. PMID:22349221
Composite structural motifs of binding sites for delineating biological functions of proteins. PMID:22347478
Crystal structures of N-acetylmannosamine kinase provide insights into enzyme activity and inhibition. PMID:22343627
Crystal structure and biochemical properties of putrescine carbamoyltransferase from Enterococcus faecalis: Assembly, active site, and allosteric regulation. PMID:22328207
Plant UVR8 photoreceptor senses UV-B by tryptophan-mediated disruption of cross-dimer salt bridges. PMID:22323738
Automated protein structure modeling with SWISS-MODEL Workspace and the Protein Model Portal. PMID:22323219
Structurally similar but functionally diverse ZU5 domains in human erythrocyte ankyrin. PMID:22310050
Optimizing ring assembly reveals the strength of weak interactions. PMID:22308356
Insights into Chi recognition from the structure of an AddAB-type helicase-nuclease complex. PMID:22307084
Structural, bioinformatic, and in vivo analyses of two Treponema pallidum lipoproteins reveal a unique TRAP transporter. PMID:22306465
CENP-T-W-S-X forms a unique centromeric chromatin structure with a histone-like fold. PMID:22304917
Homology inference of protein-protein interactions via conserved binding sites. PMID:22303436
Lysozyme contamination facilitates crystallization of a heterotrimeric cortactin-Arg-lysozyme complex. PMID:22297987
Crystal structures and small-angle x-ray scattering analysis of UDP-galactopyranose mutase from the pathogenic fungus Aspergillus fumigatus. PMID:22294687
Chemical shift prediction for protein structure calculation and quality assessment using an optimally parameterized force field. PMID:22293396
Insights into structural network responsible for oligomerization and activity of bacterial virulence regulator caseinolytic protease P (ClpP) protein. PMID:22291011
Crystal structure of cce_0566 from Cyanothece 51142, a protein associated with nitrogen fixation in the DUF269 family. PMID:22289180
A human XRCC4-XLF complex bridges DNA. PMID:22287571
Structural basis for broad detection of genogroup II noroviruses by a monoclonal antibody that binds to a site occluded in the viral particle. PMID:22278249
A structural mechanism for dimeric to tetrameric oligomer conversion in Halomonas sp. nucleoside diphosphate kinase. PMID:22275000
Structural characterization of a novel Chlamydia pneumoniae type III secretion-associated protein, Cpn0803. PMID:22272312
Cloning, Baeyer-Villiger biooxidations, and structures of the camphor pathway 2-oxo-Δ(3)-4,5,5-trimethylcyclopentenylacetyl-coenzyme A monooxygenase of Pseudomonas putida ATCC 17453. PMID:22267661
Structural and biochemical basis of Yos9 protein dimerization and possible contribution to self-association of 3-hydroxy-3-methylglutaryl-coenzyme A reductase degradation ubiquitin-ligase complex. PMID:22262864
Large-scale mapping of human protein interactome using structural complexes. PMID:22261719
Structure of a novel phosphotyrosine-binding domain in Hakai that targets E-cadherin. PMID:22252131
Structural insights into the redox-switch mechanism of the MarR/DUF24-type regulator HypR. PMID:22238377
Structure-function relationship of assimilatory nitrite reductases from the leaf and root of tobacco based on high-resolution structures. PMID:22238192
Structural insights into RipC, a putative citrate lyase β subunit from a Yersinia pestis virulence operon. PMID:22232161
Mitochondrial localization and structure-based phosphate activation mechanism of Glutaminase C with implications for cancer metabolism. PMID:22228304
Quaternary ammonium oxidative demethylation: X-ray crystallographic, resonance Raman, and UV-visible spectroscopic analysis of a Rieske-type demethylase. PMID:22224443
Dimeric α-cobratoxin X-ray structure: localization of intermolecular disulfides and possible mode of binding to nicotinic acetylcholine receptors. PMID:22223648
Computational protein design with explicit consideration of surface hydrophobic patches. PMID:22223219
Molecular determinants for antibody binding on group 1 house dust mite allergens. PMID:22210776
Structural investigation of the thermostability and product specificity of amylosucrase from the bacterium Deinococcus geothermalis. PMID:22210773
Dissecting the protein-RNA interface: the role of protein surface shapes and RNA secondary structures in protein-RNA recognition. PMID:22199255
Modulating protein-protein interactions with small molecules: the importance of binding hotspots. PMID:22198293
Glycolipids that elicit IFN-γ-biased responses from natural killer T cells. PMID:22195564
Structural features and kinetic characterization of alanine racemase from Staphylococcus aureus (Mu50). PMID:22194336
Structural basis of coactivation of liver receptor homolog-1 by β-catenin. PMID:22187462
Evolutionary trace for prediction and redesign of protein functional sites. PMID:22183528
Dynamic dissociating homo-oligomers and the control of protein function. PMID:22182754
A novel N-acetylglutamate synthase architecture revealed by the crystal structure of the bifunctional enzyme from Maricaulis maris. PMID:22174908
Structural comparison of tRNA m(1)A58 methyltransferases revealed different molecular strategies to maintain their oligomeric architecture under extreme conditions. PMID:22168821
Crystal structure of the Japanese encephalitis virus envelope protein. PMID:22156523
A reverse binding motif that contributes to specific protease inhibition by antibodies. PMID:22154938
Phosphorylation in protein-protein binding: effect on stability and function. PMID:22153503
Computational design of a symmetric homodimer using β-strand assembly. PMID:22143762
Crystal structure of the DNA-bound VapBC2 antitoxin/toxin pair from Rickettsia felis. PMID:22140099
Structure of the H107R variant of the extracellular domain of mouse NKR-P1A at 2.3 Å resolution. PMID:22139156
Structure of hyperthermophilic β-glucosidase from Pyrococcus furiosus. PMID:22139147
Bifidobacterium longum subsp. infantis ATCC 15697 α-fucosidases are active on fucosylated human milk oligosaccharides. PMID:22138995
Unusual carbon fixation gives rise to diverse polyketide extender units. PMID:22138621
A conserved Glu-Arg salt bridge connects coevolved motifs that define the eukaryotic protein kinase fold. PMID:22138346
MMDB: 3D structures and macromolecular interactions. PMID:22135289
Nucleoporin Nup50 stabilizes closed conformation of armadillo repeat 10 in importin α5. PMID:22130666
Tail-anchor targeting by a Get3 tetramer: the structure of an archaeal homologue. PMID:22124326
The structure of Serratia marcescens Lip, a membrane-bound component of the type VI secretion system. PMID:22120744
The molecular basis for the endocytosis of small R-SNAREs by the clathrin adaptor CALM. PMID:22118466
Structural basis for the recognition of C20:2-αGalCer by the invariant natural killer T cell receptor-like antibody L363. PMID:22110136
PDBe: Protein Data Bank in Europe. PMID:22110033
Towards a structural comprehension of bacterial type VI secretion systems: characterization of the TssJ-TssM complex of an Escherichia coli pathovar. PMID:22102820
IBIS (Inferred Biomolecular Interaction Server) reports, predicts and integrates multiple types of conserved interactions for proteins. PMID:22102591
Purification, crystallization and diffraction studies of the methyltransferases BT_2972 and BVU_3255 from antibiotic-resistant pathogens of the genus Bacteroides from the human intestine. PMID:22102231
Crystallographic analysis of the C-terminal domain of the Escherichia coli lipoprotein BamC. PMID:22102230
Structure of cellobiose phosphorylase from Clostridium thermocellum in complex with phosphate. PMID:22102229
Structures of respiratory syncytial virus nucleocapsid protein from two crystal forms: details of potential packing interactions in the native helical form. PMID:22102022
Substrate recognition mechanism and substrate-dependent conformational changes of an ROK family glucokinase from Streptomyces griseus. PMID:22101842
High-resolution structure of a retroviral protease folded as a monomer. PMID:22101816
Structure and kinetic stability of the p63 tetramerization domain. PMID:22100306
Structural analysis of an eIF3 subcomplex reveals conserved interactions required for a stable and proper translation pre-initiation complex assembly. PMID:22090426
Diversity in the C3b [corrected] contact residues and tertiary structures of the staphylococcal complement inhibitor (SCIN) protein family. PMID:22086928
Insights into ubiquitin-conjugating enzyme/ co-activator interactions from the structure of the Pex4p:Pex22p complex. PMID:22085930
Structural insights into the catalytic mechanism of Escherichia coli selenophosphate synthetase. PMID:22081394
The Chp1-Tas3 core is a multifunctional platform critical for gene silencing by RITS. PMID:22081013
Intra-chain 3D segment swapping spawns the evolution of new multidomain protein architectures. PMID:22079367
Molecular analysis of the interaction of the snake venom rhodocytin with the platelet receptor CLEC-2. PMID:22069753
A flexible brace maintains the assembly of a hexameric replicative helicase during DNA unwinding. PMID:22067453
Inhibition mechanism of human galectin-7 by a novel galactose-benzylphosphate inhibitor. PMID:22059385
Structure of the glycosyltransferase EryCIII in complex with its activating P450 homologue EryCII. PMID:22056329
Crystal structure of thrombin in complex with S-variegin: insights of a novel mechanism of inhibition and design of tunable thrombin inhibitors. PMID:22053189
InterEvol database: exploring the structure and evolution of protein complex interfaces. PMID:22053089
A highly stable plastidic-type ferredoxin-NADP(H) reductase in the pathogenic bacterium Leptospira interrogans. PMID:22039544
Crystal structure of a heterodimer of editosome interaction proteins in complex with two copies of a cross-reacting nanobody. PMID:22039098
Bioinformatic analysis of pathogenic missense mutations of activin receptor like kinase 1 ectodomain. PMID:22028876
Structural basis for partial redundancy in a class of transcription factors, the LIM homeodomain proteins, in neural cell type specification. PMID:22025611
Kinked β-strands mediate high-affinity recognition of mRNA targets by the germ-cell regulator DAZL. PMID:22021443
Structure of the Escherichia coli phosphonate binding protein PhnD and rationally optimized phosphonate biosensors. PMID:22019591
Evolution of a new enzyme for carbon disulphide conversion by an acidothermophilic archaeon. PMID:22012399
Flavin-induced oligomerization in Escherichia coli adaptive response protein AidB. PMID:22004173
The crystal structure of an oxygen-tolerant hydrogenase uncovers a novel iron-sulphur centre. PMID:22002606
An angiotensin I-converting enzyme mutation (Y465D) causes a dramatic increase in blood ACE via accelerated ACE shedding. PMID:21998728
Structural characterization of a ribose-5-phosphate isomerase B from the pathogenic fungus Coccidioides immitis. PMID:21995815
Insights into the membrane interactions of the saposin-like proteins Na-SLP-1 and Ac-SLP-1 from human and dog hookworm. PMID:21991310
Assessment of ligand-binding residue predictions in CASP9. PMID:21987472
Changes in dynamics upon oligomerization regulate substrate binding and allostery in amino acid kinase family members. PMID:21980279
Oligomeric structure of the MALT1 tandem Ig-like domains. PMID:21966355
Crystal structure of the passenger domain of the Escherichia coli autotransporter EspP. PMID:21964244
Structural analyses of a purine biosynthetic enzyme from Mycobacterium tuberculosis reveal a novel bound nucleotide. PMID:21956117
Structural characterization of human Uch37. PMID:21953935
Co-crystal structures of inhibitors with MRCKβ, a key regulator of tumor cell invasion. PMID:21949762
Temperature-sensitive mutants of RNase E in Salmonella enterica. PMID:21949072
Structural basis for cell surface patterning through NetrinG-NGL interactions. PMID:21946559
High-throughput genetic identification of functionally important regions of the yeast DEAD-box protein Mss116p. PMID:21945532
The UlaG protein family defines novel structural and functional motifs grafted on an ancient RNase fold. PMID:21943130
Crystal structure of β-barrel assembly machinery BamCD protein complex. PMID:21937441
Pseudomonas aeruginosa 4-amino-4-deoxychorismate lyase: spatial conservation of an active site tyrosine and classification of two types of enzyme. PMID:21935381
Membrane remodeling by the double-barrel scaffolding protein of poxvirus. PMID:21931553
Structural and functional studies on the interaction of GspC and GspD in the type II secretion system. PMID:21931548
α-Galactosidase/sucrose kinase (AgaSK), a novel bifunctional enzyme from the human microbiome coupling galactosidase and kinase activities. PMID:21931163
Remote control of regioselectivity in acyl-acyl carrier protein-desaturases. PMID:21930947
Discrimination between biological interfaces and crystal-packing contacts. PMID:21918609
Novel pentameric structure of the diarrhea-inducing region of the rotavirus enterotoxigenic protein NSP4. PMID:21917949
Structural and immunologic characterization of Ara h 1, a major peanut allergen. PMID:21917921
A conserved lysine residue of plant Whirly proteins is necessary for higher order protein assembly and protection against DNA damage. PMID:21911368
Structure of fumarate hydratase from Rickettsia prowazekii, the agent of typhus and suspected relative of the mitochondria. PMID:21904061
Structure of 3-ketoacyl-(acyl-carrier-protein) reductase from Rickettsia prowazekii at 2.25 Å resolution. PMID:21904060
BrabA.11339.a: anomalous diffraction and ligand binding guide towards the elucidation of the function of a 'putative β-lactamase-like protein' from Brucella melitensis. PMID:21904058
Structure of nitrilotriacetate monooxygenase component B from Mycobacterium thermoresistibile. PMID:21904057
Structure of triosephosphate isomerase from Cryptosporidium parvum. PMID:21904056
Structure of thymidylate kinase from Ehrlichia chaffeensis. PMID:21904055
Structure of fructose bisphosphate aldolase from Encephalitozoon cuniculi. PMID:21904050
Rational disruption of the oligomerization of the mini-ferritin E. coli DPS through protein-protein interface mutation. PMID:21898653
In silico approach to inhibition of signaling pathways of Toll-like receptors 2 and 4 by ST2L. PMID:21897866
Structural basis for the role of the Sir3 AAA+ domain in silencing: interaction with Sir4 and unmethylated histone H3K79. PMID:21896656
Crystal structure of cGMP-dependent protein kinase reveals novel site of interchain communication. PMID:21893290
Structural basis for complex formation between human IRSp53 and the translocated intimin receptor Tir of enterohemorrhagic E. coli. PMID:21893288
Crystal structures of an archaeal class II DNA photolyase and its complex with UV-damaged duplex DNA. PMID:21892138
OPM database and PPM web server: resources for positioning of proteins in membranes. PMID:21890895
Structure and mechanism of the lipooligosaccharide sialyltransferase from Neisseria meningitidis. PMID:21880735
An inserted α/β subdomain shapes the catalytic pocket of Lactobacillus johnsonii cinnamoyl esterase. PMID:21876742
Mechanism of actin filament nucleation by the bacterial effector VopL. PMID:21873984
Crystal structure of Toll-like receptor adaptor MAL/TIRAP reveals the molecular basis for signal transduction and disease protection. PMID:21873236
Structure of a light-activated LOV protein dimer that regulates transcription. PMID:21868352
A crystal structure of the catalytic core domain of an avian sarcoma and leukemia virus integrase suggests an alternate dimeric assembly. PMID:21857987
Mechanism of ubiquitylation by dimeric RING ligase RNF4. PMID:21857666
Ligand-induced conformational changes within a hexameric Acyl-CoA thioesterase. PMID:21849495
Structure of the food-poisoning Clostridium perfringens enterotoxin reveals similarity to the aerolysin-like pore-forming toxins. PMID:21839091
Crystal structure of N-domain of FKBP22 from Shewanella sp. SIB1: dimer dissociation by disruption of Val-Leu knot. PMID:21837652
The structure of the kinesin-1 motor-tail complex reveals the mechanism of autoinhibition. PMID:21836017
Focused evolution of HIV-1 neutralizing antibodies revealed by structures and deep sequencing. PMID:21835983
Structural basis for antiviral inhibition of the main protease, 3C, from human enterovirus 93. PMID:21835784
Conformational changes in 2-trans-enoyl-ACP (CoA) reductase (InhA) from M. tuberculosis induced by an inorganic complex: a molecular dynamics simulation study. PMID:21833828
A structural model of the Sgt2 protein and its interactions with chaperones and the Get4/Get5 complex. PMID:21832041
X-ray structure reveals a new class and provides insight into evolution of alkaline phosphatases. PMID:21829507
Structure of filamin A immunoglobulin-like repeat 10 from Homo sapiens. PMID:21821884
Observation of intermolecular interactions in large protein complexes by 2D-double difference nuclear Overhauser enhancement spectroscopy: application to the 44 kDa interferon-receptor complex. PMID:21819146
New insights into the mechanism of odorant detection by the malaria-transmitting mosquito Anopheles gambiae. PMID:21816826
Structures of Phytophthora RXLR effector proteins: a conserved but adaptable fold underpins functional diversity. PMID:21813644
The P(2)' residue is a key determinant of mesotrypsin specificity: engineering a high-affinity inhibitor with anticancer activity. PMID:21806544
Comprehensive, atomic-level characterization of structurally characterized protein-protein interactions: the PICCOLO database. PMID:21801404
The crystal structure of the human co-chaperone P58(IPK). PMID:21799829
Structural and sequence analysis of imelysin-like proteins implicated in bacterial iron uptake. PMID:21799754
Structure of 2-oxo-3-deoxygalactonate kinase from Klebsiella pneumoniae. PMID:21795809
Crystallization and preliminary X-ray analysis of a putative sensor histidine kinase domain: the C-terminal domain of HksP4 from Aquifex aeolicus VF5. PMID:21795799
Structure of the Drosophila melanogaster Rab6 GTPase at 1.4 Å resolution. PMID:21795785
EspR, a key regulator of Mycobacterium tuberculosis virulence, adopts a unique dimeric structure among helix-turn-helix proteins. PMID:21795602
TCRs used in cancer gene therapy cross-react with MART-1/Melan-A tumor antigens via distinct mechanisms. PMID:21795600
Crystal structure of New Delhi metallo-β-lactamase reveals molecular basis for antibiotic resistance. PMID:21774017
Structural basis for complement factor I control and its disease-associated sequence polymorphisms. PMID:21768352
Crystal structure of the human astrovirus capsid spike. PMID:21768348
The nucleotide-binding domain 2 of the human transporter protein MRP6. PMID:21748403
Modular mechanism of Wnt signaling inhibition by Wnt inhibitory factor 1. PMID:21743455
Insights into the evolution of a complex virus from the crystal structure of vaccinia virus D13. PMID:21742267
Characterization of protein-protein interaction interfaces from a single species. PMID:21738603
Comparative structural analysis of lipid binding START domains. PMID:21738568
The binding of triclosan to SmeT, the repressor of the multidrug efflux pump SmeDEF, induces antibiotic resistance in Stenotrophomonas maltophilia. PMID:21738470
Molecular basis for the unique role of the AAA+ chaperone ClpV in type VI protein secretion. PMID:21733841
Identification of the allosteric regulatory site of insulysin. PMID:21731629
Structure and organisation of SinR, the master regulator of biofilm formation in Bacillus subtilis. PMID:21708175
Atomic structure of bacteriophage Sf6 tail needle knob. PMID:21705802
Structure of Candida albicans methionine synthase determined by employing surface residue mutagenesis. PMID:21689631
Mutational and structural studies of the PixD BLUF output signal that affects light-regulated interactions with PixE. PMID:21688827
Crystal structure of Bacillus anthracis phosphoglucosamine mutase, an enzyme in the peptidoglycan biosynthetic pathway. PMID:21685296
PKA phosphorylation of NDE1 is DISC1/PDE4 dependent and modulates its interaction with LIS1 and NDEL1. PMID:21677187
Crystal structure of uronate dehydrogenase from Agrobacterium tumefaciens. PMID:21676870
Architecture of the flagellar rotor. PMID:21673656
Xwalk: computing and visualizing distances in cross-linking experiments. PMID:21666267
Crystal structure of the Pseudomonas aeruginosa virulence factor regulator. PMID:21665969
Structural and functional analysis of a new subfamily of glycosyltransferases required for glycosylation of serine-rich streptococcal adhesins. PMID:21653318
ISC-like [2Fe-2S] ferredoxin (FdxB) dimer from Pseudomonas putida JCM 20004: structural and electron-nuclear double resonance characterization. PMID:21647778
Relative solvent accessible surface area predicts protein conformational changes upon binding. PMID:21645856
Broad distribution of energetically important contacts across an extended protein interface. PMID:21644542
Structural basis for the neutralization and genotype specificity of hepatitis E virus. PMID:21642534
Molecular recognition of leucine-aspartate repeat (LD) motifs by the focal adhesion targeting homology domain of cerebral cavernous malformation 3 (CCM3). PMID:21632544
The crystal structure of the α-neurexin-1 extracellular region reveals a hinge point for mediating synaptic adhesion and function. PMID:21620717
The structure of neurexin 1α reveals features promoting a role as synaptic organizer. PMID:21620716
The crystal structure of alanine racemase from Streptococcus pneumoniae, a target for structure-based drug design. PMID:21612658
Structure of Burkholderia cepacia UDP-glucose dehydrogenase (UGD) BceC and role of Tyr10 in final hydrolysis of UGD thioester intermediate. PMID:21602353
Structural analysis of a putative aminoglycoside N-acetyltransferase from Bacillus anthracis. PMID:21601576
Structure of QnrB1, a plasmid-mediated fluoroquinolone resistance factor. PMID:21597116
Structure of the PilM-PilN inner membrane type IV pilus biogenesis complex from Thermus thermophilus. PMID:21596754
Characterization of a dipartite iron uptake system from uropathogenic Escherichia coli strain F11. PMID:21596746
Diffusion of hydrophobin proteins in solution and interactions with a graphite surface. PMID:21595866
Structure-based approach to rationally design a chimeric protein for an effective vaccine against Group B Streptococcus infections. PMID:21593422
SDM--a server for predicting effects of mutations on protein stability and malfunction. PMID:21593128
Caught in self-interaction: evolutionary and functional mechanisms of protein homooligomerization. PMID:21572178
Crystal structures of a halophilic archaeal malate synthase from Haloferax volcanii and comparisons with isoforms A and G. PMID:21569248
Structure and activity of a novel archaeal β-CASP protein with N-terminal KH domains. PMID:21565697
Crystal structures of Staphylococcus epidermidis mevalonate diphosphate decarboxylase bound to inhibitory analogs reveal new insight into substrate binding and catalysis. PMID:21561869
The crystal structure and mechanism of an unusual oxidoreductase, GilR, involved in gilvocarcin V biosynthesis. PMID:21561854
Crystal structure of the heteromolecular chaperone, AscE-AscG, from the type III secretion system in Aeromonas hydrophila. PMID:21559439
Crystal structures of Burkholderia cenocepacia dihydropteroate synthase in the apo-form and complexed with the product 7,8-dihydropteroate. PMID:21554707
Critical factors governing the difference in antizyme-binding affinities between human ornithine decarboxylase and antizyme inhibitor. PMID:21552531
Idas, a novel phylogenetically conserved geminin-related protein, binds to geminin and is required for cell cycle progression. PMID:21543332
Crystal structure of a metal-dependent phosphoesterase (YP_910028.1) from Bifidobacterium adolescentis: Computational prediction and experimental validation of phosphoesterase activity. PMID:21538547
Identification of amino acids that account for long-range interactions in two triosephosphate isomerases from pathogenic trypanosomes. PMID:21533154
Molecular recognition of chymotrypsin by the serine protease inhibitor ecotin from Yersinia pestis. PMID:21531711
The ancestral role of ATP hydrolysis in type II topoisomerases: prevention of DNA double-strand breaks. PMID:21525132
The virulence factor PEB4 (Cj0596) and the periplasmic protein Cj1289 are two structurally related SurA-like chaperones in the human pathogen Campylobacter jejuni. PMID:21524997
Conformational changes in IgE contribute to its uniquely slow dissociation rate from receptor FcɛRI. PMID:21516097
Exploiting the high-resolution crystal structure of Staphylococcus aureus MenH to gain insight into enzyme activity. PMID:21513522
Molecular mechanisms of viral and host cell substrate recognition by hepatitis C virus NS3/4A protease. PMID:21507982
The Leishmania donovani UMP synthase is essential for promastigote viability and has an unusual tetrameric structure that exhibits substrate-controlled oligomerization. PMID:21507942
Three-dimensional structure of a viral genome-delivery portal vertex. PMID:21499245
Structure of an archaeal-type phosphoenolpyruvate carboxylase sensitive to inhibition by aspartate. PMID:21491491
Structural basis of neutralization of the major toxic component from the scorpion Centruroides noxius Hoffmann by a human-derived single-chain antibody fragment. PMID:21489992
Mapping the IkappaB kinase beta (IKKbeta)-binding interface of the B14 protein, a vaccinia virus inhibitor of IKKbeta-mediated activation of nuclear factor kappaB. PMID:21474453
Evidence of the participation of remote residues in the catalytic activity of Co-type nitrile hydratase from Pseudomonas putida. PMID:21473592
Small angle X-ray scattering as a complementary tool for high-throughput structural studies. PMID:21462184
Presenting your structures: the CCP4mg molecular-graphics software. PMID:21460457
Macromolecular complexes in crystals and solutions. PMID:21460456
The Protein Data Bank in Europe (PDBe): bringing structure to biology. PMID:21460450
Overview of the CCP4 suite and current developments. PMID:21460441
Structure of human C8 protein provides mechanistic insight into membrane pore formation by complement. PMID:21454577
The E3 ubiquitin ligase- and protein phosphatase 2A (PP2A)-binding domains of the Alpha4 protein are both required for Alpha4 to inhibit PP2A degradation. PMID:21454489
Structure and function of the first full-length murein peptide ligase (Mpl) cell wall recycling protein. PMID:21445265
Crystal structure of human natural cytotoxicity receptor NKp30 and identification of its ligand binding site. PMID:21444796
Unexpected diversity of chlorite dismutases: a catalytically efficient dimeric enzyme from Nitrobacter winogradskyi. PMID:21441524
Structural analysis of a novel class of R-M controller proteins: C.Csp231I from Citrobacter sp. RFL231. PMID:21440553
Structure and binding analysis of Polyporus squamosus lectin in complex with the Neu5Ac{alpha}2-6Gal{beta}1-4GlcNAc human-type influenza receptor. PMID:21436237
Adaptive evolution of threonine deaminase in plant defense against insect herbivores. PMID:21436043
The double-length tyrosyl-tRNA synthetase from the eukaryote Leishmania major forms an intrinsically asymmetric pseudo-dimer. PMID:21420975
Crystal structure of tarocystatin-papain complex: implications for the inhibition property of group-2 phytocystatins. PMID:21416241
Conformational flexibility of the ligand-binding domain dimer in kainate receptor gating and desensitization. PMID:21414913
Structure of the HECT:ubiquitin complex and its role in ubiquitin chain elongation. PMID:21399620
Interferon-inducible protein 16: insight into the interaction with tumor suppressor p53. PMID:21397192
Nine crystal structures determine the substrate envelope of the MDR HIV-1 protease. PMID:21394574
Crystallization and preliminary X-ray analysis of mannosyl-3-phosphoglycerate phosphatase from Thermus thermophilus HB27. PMID:21393850
Structure of the extended-spectrum β-lactamase TEM-72 inhibited by citrate. PMID:21393831
Pentapeptide-repeat proteins that act as topoisomerase poison resistance factors have a common dimer interface. PMID:21393830
Defining a structural and kinetic rationale for paralogous copies of phenylacetate-CoA ligases from the cystic fibrosis pathogen Burkholderia cenocepacia J2315. PMID:21388965
Structural basis for a ribofuranosyl binding protein: insights into the furanose specific transport. PMID:21387413
Structure of the C-terminal heme-binding domain of THAP domain containing protein 4 from Homo sapiens. PMID:21387410
Crystal structure of Archaeoglobus fulgidus CTP:inositol-1-phosphate cytidylyltransferase, a key enzyme for di-myo-inositol-phosphate synthesis in (hyper)thermophiles. PMID:21378188
Crystal structure and immunogenicity of the class C acid phosphatase from Pasteurella multocida. PMID:21371420
Self-association studies of the bifunctional N-acetylglucosamine-1-phosphate uridyltransferase from Escherichia coli. PMID:21370307
Protein structure reports in JIMD--an important enhancement of journal scope. PMID:21369958
Structural characterization of CalO1: a putative orsellinic acid methyltransferase in the calicheamicin-biosynthetic pathway. PMID:21358050
HIV-1 escape from the CCR5 antagonist maraviroc associated with an altered and less-efficient mechanism of gp120-CCR5 engagement that attenuates macrophage tropism. PMID:21345957
Crystal structure of R120G disease mutant of human αB-crystallin domain dimer shows closure of a groove. PMID:21329698
Unloading RNAs in the cytoplasm: an "importin" task. PMID:21326945
Crystal Structure of the cis-Dimer of Nectin-1: implications for the architecture of cell-cell junctions. PMID:21325282
Structure of the periplasmic stress response protein CpxP. PMID:21317318
Characterization of the interactions between the nucleoprotein and the phosphoprotein of Henipavirus. PMID:21317293
Energetics of SecA dimerization. PMID:21315086
Crystal structure of the sensory domain of Escherichia coli CadC, a member of the ToxR-like protein family. PMID:21308846
Structural basis for c-di-GMP-mediated inside-out signaling controlling periplasmic proteolysis. PMID:21304926
Structure of the dimeric form of CTP synthase from Sulfolobus solfataricus. PMID:21301086
Realizing the allosteric potential of the tetrameric protein kinase A RIα holoenzyme. PMID:21300294
Molecular basis of 1,6-anhydro bond cleavage and phosphoryl transfer by Pseudomonas aeruginosa 1,6-anhydro-N-acetylmuramic acid kinase. PMID:21288904
The structure of the plakin domain of plectin reveals a non-canonical SH3 domain interacting with its fourth spectrin repeat. PMID:21288893
Molecular recognition of the Tes LIM2-3 domains by the actin-related protein Arp7A. PMID:21278383
Structural basis of the 9-fold symmetry of centrioles. PMID:21277013
Crystal structures of two active proliferating cell nuclear antigens (PCNAs) encoded by Thermococcus kodakaraensis. PMID:21270332
Crystal structure of a bacterial phosphoglucomutase, an enzyme involved in the virulence of multiple human pathogens. PMID:21246636
Modulation of the pharmacological activities of secretory phospholipase A2 from Crotalus durissus cascavella induced by naringin. PMID:21245808
Structural basis for the removal of ubiquitin and interferon-stimulated gene 15 by a viral ovarian tumor domain-containing protease. PMID:21245344
PCNA directs type 2 RNase H activity on DNA replication and repair substrates. PMID:21245041
Structural basis of substrate discrimination and integrin binding by autotaxin. PMID:21240271
Structural basis for two-component system inhibition and pilus sensing by the auxiliary CpxP protein. PMID:21239493
Structural insights into quinolone antibiotic resistance mediated by pentapeptide repeat proteins: conserved surface loops direct the activity of a Qnr protein from a gram-negative bacterium. PMID:21227918
Protein structure databases. PMID:21225378
Structural basis for MOF and MSL3 recruitment into the dosage compensation complex by MSL1. PMID:21217699
Substrate recognition by complement convertases revealed in the C5-cobra venom factor complex. PMID:21217642
Crystal structure of arrestin-3 reveals the basis of the difference in receptor binding between two non-visual subtypes. PMID:21215759
Structure-activity analysis of cathepsin K/chondroitin 4-sulfate interactions. PMID:21193413
Glutathione transferases of Phanerochaete chrysosporium: S-glutathionyl-p-hydroquinone reductase belongs to a new structural class. PMID:21177852
Three clusters of conformational states in p450cam reveal a multistep pathway for closing of the substrate access channel. PMID:21171581
Deriving the ultrastructure of α-crustacyanin using lower-resolution structural and biophysical methods. PMID:21169698
Structure of Leishmania major methionyl-tRNA synthetase in complex with intermediate products methionyladenylate and pyrophosphate. PMID:21144880
Thermodynamic characterization of the binding interaction between the histone demethylase LSD1/KDM1 and CoREST. PMID:21142040
Structure of Importin13-Ubc9 complex: nuclear import and release of a key regulator of sumoylation. PMID:21139563
Structure of Hsp33/YOR391Cp from the yeast Saccharomyces cerevisiae. PMID:21139195
Toward the estimation of the absolute quality of individual protein structure models. PMID:21134891
Structural basis of tumor suppressor in lung cancer 1 (TSLC1) binding to differentially expressed in adenocarcinoma of the lung (DAL-1/4.1B). PMID:21131357
Insights into Mycoplasma genitalium metabolism revealed by the structure of MG289, an extracytoplasmic thiamine binding lipoprotein. PMID:21117240
Novel folding and stability defects cause a deficiency of human glutathione transferase omega 1. PMID:21106529
The structure of the CRISPR-associated protein Csa3 provides insight into the regulation of the CRISPR/Cas system. PMID:21093452
Drug resistance against HCV NS3/4A inhibitors is defined by the balance of substrate recognition versus inhibitor binding. PMID:21084633
Structural basis for substrate activation and regulation by cystathionine beta-synthase (CBS) domains in cystathionine {beta}-synthase. PMID:21081698
BISC: binary subcomplexes in proteins database. PMID:21081561
Crystal structure of heterodimeric hexaprenyl diphosphate synthase from Micrococcus luteus B-P 26 reveals that the small subunit is directly involved in the product chain length regulation. PMID:21068379
Structure and folding of a designed knotted protein. PMID:21068371
A dimeric Rep protein initiates replication of a linear archaeal virus genome: implications for the Rep mechanism and viral replication. PMID:21068244
tRNA(His) guanylyltransferase (THG1), a unique 3'-5' nucleotidyl transferase, shares unexpected structural homology with canonical 5'-3' DNA polymerases. PMID:21059936
A prominent β-hairpin structure in the winged-helix domain of RECQ1 is required for DNA unwinding and oligomer formation. PMID:21059676
A structural basis for Staphylococcal complement subversion: X-ray structure of the complement-binding domain of Staphylococcus aureus protein Sbi in complex with ligand C3d. PMID:21055811
Mechanisms of protein oligomerization, the critical role of insertions and deletions in maintaining different oligomeric states. PMID:21048085
Insights into association of the NuRD complex with FOG-1 from the crystal structure of an RbAp48·FOG-1 complex. PMID:21047798
The homodimeric GBS1074 from Streptococcus agalactiae. PMID:21045286
Structural analysis of Bacillus pumilus phenolic acid decarboxylase, a lipocalin-fold enzyme. PMID:21045284
PDBe: Protein Data Bank in Europe. PMID:21045060
Structure of the bacteriophage T4 long tail fiber receptor-binding tip. PMID:21041684
X-ray structure and site-directed mutagenesis analysis of the Escherichia coli colicin M immunity protein. PMID:21037007
The RCSB Protein Data Bank: redesigned web site and web services. PMID:21036868
The protein common interface database (ProtCID)--a comprehensive database of interactions of homologous proteins in multiple crystal forms. PMID:21036862
The crystal structures of the Salmonella type III secretion system tip protein SipD in complex with deoxycholate and chenodeoxycholate. PMID:21031487
Directed evolution of a thermostable quorum-quenching lactonase from the amidohydrolase superfamily. PMID:20980257
Structural basis for the interaction between the growth factor-binding protein GRB10 and the E3 ubiquitin ligase NEDD4. PMID:20980250
Ferredoxin:NADPH oxidoreductase is recruited to thylakoids by binding to a polyproline type II helix in a pH-dependent manner. PMID:20974920
Structural and biological properties of the Drosophila insulin-like peptide 5 show evolutionary conservation. PMID:20974844
Structures of a key interaction protein from the Trypanosoma brucei editosome in complex with single domain antibodies. PMID:20969962
Domain organization in Candida glabrata THI6, a bifunctional enzyme required for thiamin biosynthesis in eukaryotes. PMID:20968298
Molecular rearrangements involved in the capsid shell maturation of bacteriophage T7. PMID:20962334
A conserved protein interaction interface on the type 5 G protein beta subunit controls proteolytic stability and activity of R7 family regulator of G protein signaling proteins. PMID:20959458
Crystal structure of group II chaperonin in the open state. PMID:20947016
Conformational changes associated with the binding of zinc acetate at the putative active site of XcTcmJ, a cupin from Xanthomonas campestris pv. campestris. PMID:20944231
Structures of three members of Pfam PF02663 (FmdE) implicated in microbial methanogenesis reveal a conserved α+β core domain and an auxiliary C-terminal treble-clef zinc finger. PMID:20944230
Structure of Bacteroides thetaiotaomicron BT2081 at 2.05 Å resolution: the first structural representative of a new protein family that may play a role in carbohydrate metabolism. PMID:20944224
Structure of BT_3984, a member of the SusD/RagB family of nutrient-binding molecules. PMID:20944222
Open and closed conformations of two SpoIIAA-like proteins (YP_749275.1 and YP_001095227.1) provide insights into membrane association and ligand binding. PMID:20944218
Structure of a putative NTP pyrophosphohydrolase: YP_001813558.1 from Exiguobacterium sibiricum 255-15. PMID:20944217
Structure of an essential bacterial protein YeaZ (TM0874) from Thermotoga maritima at 2.5 Å resolution. PMID:20944216
Structures of the first representatives of Pfam family PF06938 (DUF1285) reveal a new fold with repeated structural motifs and possible involvement in signal transduction. PMID:20944214
The structure of the first representative of Pfam family PF06475 reveals a new fold with possible involvement in glycolipid metabolism. PMID:20944213
Structure of LP2179, the first representative of Pfam family PF08866, suggests a new fold with a role in amino-acid metabolism. PMID:20944212
The structure of Jann_2411 (DUF1470) from Jannaschia sp. at 1.45 Å resolution reveals a new fold (the ABATE domain) and suggests its possible role as a transcription regulator. PMID:20944211
Structures of the first representatives of Pfam family PF06684 (DUF1185) reveal a novel variant of the Bacillus chorismate mutase fold and suggest a role in amino-acid metabolism. PMID:20944209
Structure of the first representative of Pfam family PF04016 (DUF364) reveals enolase and Rossmann-like folds that combine to form a unique active site with a possible role in heavy-metal chelation. PMID:20944207
The structure of SSO2064, the first representative of Pfam family PF01796, reveals a novel two-domain zinc-ribbon OB-fold architecture with a potential acyl-CoA-binding role. PMID:20944206
Structure of the first representative of Pfam family PF09410 (DUF2006) reveals a structural signature of the calycin superfamily that suggests a role in lipid metabolism. PMID:20944205
Comparative structural analysis of human DEAD-box RNA helicases. PMID:20941364
Crystal structure of human interferon-λ1 in complex with its high-affinity receptor interferon-λR1. PMID:20934432
PyETV: a PyMOL evolutionary trace viewer to analyze functional site predictions in protein complexes. PMID:20929911
Crystal structure of Leishmania major oligopeptidase B gives insight into the enzymatic properties of a trypanosomatid virulence factor. PMID:20926390
Structure of a major antigenic site on the respiratory syncytial virus fusion glycoprotein in complex with neutralizing antibody 101F. PMID:20881049
Interaction of decay-accelerating factor with echovirus 7. PMID:20881044
Additional serine/threonine phosphorylation reduces binding affinity but preserves interface topography of substrate proteins to the c-Cbl TKB domain. PMID:20877636
Structural basis of semaphorin-plexin signalling. PMID:20877282
Structure of an Ebf1:DNA complex reveals unusual DNA recognition and structural homology with Rel proteins. PMID:20876732
Crystal structure of the RNA recognition motif of yeast translation initiation factor eIF3b reveals differences to human eIF3b. PMID:20862284
The crystal structure of Toxoplasma gondii pyruvate kinase 1. PMID:20856875
Crystal structure of bacteriophage SPP1 distal tail protein (gp19.1): a baseplate hub paradigm in gram-positive infecting phages. PMID:20843802
Structural and kinetic characterization of 4-hydroxy-4-methyl-2-oxoglutarate/4-carboxy-4-hydroxy-2-oxoadipate aldolase, a protocatechuate degradation enzyme evolutionarily convergent with the HpaI and DmpG pyruvate aldolases. PMID:20843800
Crystallographic and nuclear magnetic resonance evaluation of the impact of peptide binding to the second PDZ domain of protein tyrosine phosphatase 1E. PMID:20839809
Structural profiling of endogenous S-nitrosocysteine residues reveals unique features that accommodate diverse mechanisms for protein S-nitrosylation. PMID:20837516
An antibody as surrogate receptor reveals determinants of activity of an innate immune peptide antibiotic. PMID:20837490
The crystal structure of a bacterial Sufu-like protein defines a novel group of bacterial proteins that are similar to the N-terminal domain of human Sufu. PMID:20836087
Kinetic and structural evidence of the alkenal/one reductase specificity of human ζ-crystallin. PMID:20835842
The N domain of human angiotensin-I-converting enzyme: the role of N-glycosylation and the crystal structure in complex with an N domain-specific phosphinic inhibitor, RXP407. PMID:20826823
Biochemical characterization of the transcriptional regulator BzdR from Azoarcus sp. CIB. PMID:20826820
Structural and mechanistic studies on Klebsiella pneumoniae 2-Oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase. PMID:20826786
Structure and cellular roles of the RMI core complex from the bloom syndrome dissolvasome. PMID:20826341
High-resolution structure of an alpha-spectrin SH3-domain mutant with a redesigned hydrophobic core. PMID:20823517
Near-atomic resolution analysis of BipD, a component of the type III secretion system of Burkholderia pseudomallei. PMID:20823511
M-ORBIS: mapping of molecular binding sites and surfaces. PMID:20813758
Structural insights into the quinolone resistance mechanism of Mycobacterium tuberculosis DNA gyrase. PMID:20805881
Structural insights into cis element recognition of non-polyadenylated RNAs by the Nab3-RRM. PMID:20805243
Folding, DNA recognition, and function of GIY-YIG endonucleases: crystal structures of R.Eco29kI. PMID:20800503
H-NS forms a superhelical protein scaffold for DNA condensation. PMID:20798056
Implications for collagen binding from the crystallographic structure of fibronectin 6FnI1-2FnII7FnI. PMID:20739283
Functional differences of invariant and highly conserved residues in the extracellular domain of the glycoprotein hormone receptors. PMID:20736161
Identification, subcellular localization, biochemical properties, and high-resolution crystal structure of Trypanosoma brucei UDP-glucose pyrophosphorylase. PMID:20724435
Crystal structures of Phd-Doc, HigA, and YeeU establish multiple evolutionary links between microbial growth-regulating toxin-antitoxin systems. PMID:20696400
Molecular basis for the association of human E4B U box ubiquitin ligase with E2-conjugating enzymes UbcH5c and Ubc4. PMID:20696396
Structure of Staphylococcus aureus adenylosuccinate lyase (PurB) and assessment of its potential as a target for structure-based inhibitor discovery. PMID:20693687
Crystallographic structure of porcine adenovirus type 4 fiber head and galectin domains. PMID:20686025
Crystal structure of Bacillus subtilis SPP1 phage gp23.1, a putative chaperone. PMID:20665904
Crystal structure of human thioredoxin revealing an unraveled helix and exposed S-nitrosation site. PMID:20662007
Molecular basis for complement recognition and inhibition determined by crystallographic studies of the staphylococcal complement inhibitor (SCIN) bound to C3c and C3b. PMID:20654625
Protein subunit interfaces: A statistical analysis of hot spots in Sm proteins. PMID:20652820
Crystal structure of the P2 C-repressor: a binder of non-palindromic direct DNA repeats. PMID:20639540
Evidence for alternative quaternary structure in a bacterial Type III secretion system chaperone. PMID:20633281
Evolution of new enzymatic function by structural modulation of cysteine reactivity in Pseudomonas fluorescens isocyanide hydratase. PMID:20630867
The crystal structure of the Mycobacterium tuberculosis Rv3019c-Rv3020c ESX complex reveals a domain-swapped heterotetramer. PMID:20629176
The mechanism of prion inhibition by HET-S. PMID:20620958
Structure of the Escherichia coli RNA polymerase alpha subunit C-terminal domain. PMID:20606261
A large-scale conformational change couples membrane recruitment to cargo binding in the AP2 clathrin adaptor complex. PMID:20603002
Structure and reactivity of Bacillus subtilis MenD catalyzing the first committed step in menaquinone biosynthesis. PMID:20600129
P. aeruginosa PilT structures with and without nucleotide reveal a dynamic type IV pilus retraction motor. PMID:20595000
Structure of the cytoplasmic segment of histidine kinase receptor QseC, a key player in bacterial virulence. PMID:20594156
Structural determination of functional domains in early B-cell factor (EBF) family of transcription factors reveals similarities to Rel DNA-binding proteins and a novel dimerization motif. PMID:20592035
Structural analysis of Saccharomyces cerevisiae alpha-galactosidase and its complexes with natural substrates reveals new insights into substrate specificity of GH27 glycosidases. PMID:20592022
The minimal autoinhibited unit of the guanine nucleotide exchange factor intersectin. PMID:20585582
Boron toxicity tolerance in barley through reduced expression of the multifunctional aquaporin HvNIP2;1. PMID:20581256
Structural insights into the catalytic mechanism of bacterial guanosine-diphospho-D-mannose pyrophosphorylase and its regulation by divalent ions. PMID:20573954
Cloning, overexpression, purification and preliminary characterization of human septin 8. PMID:20544379
Intrinsic disorder and protein multibinding in domain, terminal, and linker regions. PMID:20544079
Crystal structure of arginase from Plasmodium falciparum and implications for L-arginine depletion in malarial infection. PMID:20527960
ANCHOR: a web server and database for analysis of protein-protein interaction binding pockets for drug discovery. PMID:20525787
dockYard--a repository to assist modeling of protein-protein docking. PMID:20524020
The structure of PhaZ7 at atomic (1.2 A) resolution reveals details of the active site and suggests a substrate-binding mode. PMID:20516591
Crystal structure of Bacillus subtilis SPP1 phage gp22 shares fold similarity with a domain of lactococcal phage p2 RBP. PMID:20506290
Structural and kinetic analysis of free methionine-R-sulfoxide reductase from Staphylococcus aureus: conformational changes during catalysis and implications for the catalytic and inhibitory mechanisms. PMID:20504774
Mutational analysis of VIM-2 reveals an essential determinant for metallo-beta-lactamase stability and folding. PMID:20498317
Intermolecular interactions in a 44 kDa interferon-receptor complex detected by asymmetric reverse-protonation and two-dimensional NOESY. PMID:20496919
Crystal structure of CCM3, a cerebral cavernous malformation protein critical for vascular integrity. PMID:20489202
The structural and energetic basis for high selectivity in a high-affinity protein-protein interaction. PMID:20479265
Conformational selection in the recognition of the snurportin importin beta binding domain by importin beta. PMID:20476751
The multifunctional protein in peroxisomal beta-oxidation: structure and substrate specificity of the Arabidopsis thaliana protein MFP2. PMID:20463021
A single mutation promotes amyloidogenicity through a highly promiscuous dimer interface. PMID:20462490
The mechanism and control of DNA transfer by the conjugative relaxase of resistance plasmid pCU1. PMID:20448025
Dramatic improvement of crystal quality for low-temperature-grown rabbit muscle aldolase. PMID:20445268
Structure of dehaloperoxidase B at 1.58 A resolution and structural characterization of the AB dimer from Amphitrite ornata. PMID:20445228
Plastid-associated porphobilinogen synthase from Toxoplasma gondii: kinetic and structural properties validate therapeutic potential. PMID:20442414
Crystal structures of truncated alphaA and alphaB crystallins reveal structural mechanisms of polydispersity important for eye lens function. PMID:20440841
The structure of tryptophanyl-tRNA synthetase from Giardia lamblia reveals divergence from eukaryotic homologs. PMID:20438846
A biophysical elucidation for less toxicity of agglutinin than abrin-a from the seeds of Abrus precatorius in consequence of crystal structure. PMID:20433687
Structure and RNA recognition by the snRNA and snoRNA transport factor PHAX. PMID:20430857
Functional hybrid rubisco enzymes with plant small subunits and algal large subunits: engineered rbcS cDNA for expression in chlamydomonas. PMID:20424165
Structural characterization of acylimine-containing blue and red chromophores in mTagBFP and TagRFP fluorescent proteins. PMID:20416505
X-ray structures of isopentenyl phosphate kinase. PMID:20402538
Mutation of archaeal isopentenyl phosphate kinase highlights mechanism and guides phosphorylation of additional isoprenoid monophosphates. PMID:20392112
A computational analysis of the antigenic properties of haemagglutinin in influenza A H3N2. PMID:20388627
Quality assessment of protein model-structures using evolutionary conservation. PMID:20385730
Functional states of homooligomers: insights from the evolution of glycosyltransferases. PMID:20381499
Dimeric architecture of the Hendra virus attachment glycoprotein: evidence for a conserved mode of assembly. PMID:20375167
Crystal structure of aminomethyltransferase in complex with dihydrolipoyl-H-protein of the glycine cleavage system: implications for recognition of lipoyl protein substrate, disease-related mutations, and reaction mechanism. PMID:20375021
Structural determinants underlying photoprotection in the photoactive orange carotenoid protein of cyanobacteria. PMID:20368334
Structural and functional characterization of an RNase HI domain from the bifunctional protein Rv2228c from Mycobacterium tuberculosis. PMID:20363939
Structure of the FoxM1 DNA-recognition domain bound to a promoter sequence. PMID:20360045
Structural basis for substrate selectivity in human maltase-glucoamylase and sucrase-isomaltase N-terminal domains. PMID:20356844
Structural analysis of Thermus thermophilus HB27 mannosyl-3-phosphoglycerate synthase provides evidence for a second catalytic metal ion and new insight into the retaining mechanism of glycosyltransferases. PMID:20356840
Structure of lactococcal phage p2 baseplate and its mechanism of activation. PMID:20351260
The short-chain oxidoreductase Q9HYA2 from Pseudomonas aeruginosa PAO1 contains an atypical catalytic center. PMID:20340135
High-resolution x-ray structure and functional analysis of the murine norovirus 1 capsid protein protruding domain. PMID:20335262
Structural and biochemical characterization of peroxiredoxin Qbeta from Xylella fastidiosa: catalytic mechanism and high reactivity. PMID:20335172
Structures of the autoproteolytic domain from the Saccharomyces cerevisiae nuclear pore complex component, Nup145. PMID:20310066
Structural characterization of apical membrane antigen 1 (AMA1) from Toxoplasma gondii. PMID:20304917
Structural basis of cell wall cleavage by a staphylococcal autolysin. PMID:20300605
Structural basis for receptor recognition of vitamin-B(12)-intrinsic factor complexes. PMID:20237569
Implications of the HIV-1 Rev dimer structure at 3.2 A resolution for multimeric binding to the Rev response element. PMID:20231488
Sorting of the Alzheimer's disease amyloid precursor protein mediated by the AP-4 complex. PMID:20230749
Crystal structure of an eIF4G-like protein from Danio rerio. PMID:20229607
Structure at 1.0 A resolution of a high-potential iron-sulfur protein involved in the aerobic respiratory chain of Rhodothermus marinus. PMID:20225399
Structure of the GLD-1 homodimerization domain: insights into STAR protein-mediated translational regulation. PMID:20223220
Molecular basis for shared cytokine recognition revealed in the structure of an unusually high affinity complex between IL-13 and IL-13Ralpha2. PMID:20223216
Structure of the catalytic domain of the human mitochondrial Lon protease: proposed relation of oligomer formation and activity. PMID:20222013
Structure and biochemical analysis of the heparin-induced E1 dimer of the amyloid precursor protein. PMID:20212142
A triclinic crystal form of Escherichia coli 4-diphosphocytidyl-2C-methyl-D-erythritol kinase and reassessment of the quaternary structure. PMID:20208151
The structure of DinB from Geobacillus stearothermophilus: a representative of a unique four-helix-bundle superfamily. PMID:20208147
Visualization of macromolecular structures. PMID:20195256
Structural and kinetic analysis of Schwanniomyces occidentalis invertase reveals a new oligomerization pattern and the role of its supplementary domain in substrate binding. PMID:20181943
The coxsackievirus-adenovirus receptor reveals complex homophilic and heterophilic interactions on neural cells. PMID:20181587
Structural basis for the function of DEAH helicases. PMID:20168331
AlgK is a TPR-containing protein and the periplasmic component of a novel exopolysaccharide secretin. PMID:20159471
The structure of the catalytic subunit FANCL of the Fanconi anemia core complex. PMID:20154706
Crystal structure of the APOBEC3G catalytic domain reveals potential oligomerization interfaces. PMID:20152150
Crystal structure and functional insights of hemopexin fold protein from grass pea. PMID:20147493
Transient dimers of allergens. PMID:20140203
A single-domain llama antibody potently inhibits the enzymatic activity of botulinum neurotoxin by binding to the non-catalytic alpha-exosite binding region. PMID:20138889
Bacillus licheniformis Anti-TRAP can assemble into two types of dodecameric particles with the same symmetry but inverted orientation of trimers. PMID:20138150
Structural insight into M-band assembly and mechanics from the titin-obscurin-like-1 complex. PMID:20133654
A new crystal form of human diamine oxidase. PMID:20124708
Crystal structure of the first eubacterial Mre11 nuclease reveals novel features that may discriminate substrates during DNA repair. PMID:20122942
Structural basis of respiratory syncytial virus neutralization by motavizumab. PMID:20098425
Structural basis of substrate binding in WsaF, a rhamnosyltransferase from Geobacillus stearothermophilus. PMID:20097205
Global conformational change associated with the two-step reaction catalyzed by Escherichia coli lipoate-protein ligase A. PMID:20089862
ZBP1 recognition of beta-actin zipcode induces RNA looping. PMID:20080952
Metal templated design of protein interfaces. PMID:20080561
Heterologous quaternary structure of CXCL12 and its relationship to the CC chemokine family. PMID:20077567
Structural and functional characterization of a novel homodimeric three-finger neurotoxin from the venom of Ophiophagus hannah (king cobra). PMID:20071329
The crystal structure and activity of a putative trypanosomal nucleoside phosphorylase reveal it to be a homodimeric uridine phosphorylase. PMID:20070944
The high-resolution structure of the extracellular domain of human CD69 using a novel polymer. PMID:20054122
Structure of the first PDZ domain of human PSD-93. PMID:20054121
The structure of an archaeal ribose-5-phosphate isomerase from Methanocaldococcus jannaschii (MJ1603). PMID:20054114
Structure of SurE protein from Aquifex aeolicus VF5 at 1.5 A resolution. PMID:20054112
Structure of hypothetical Mo-cofactor biosynthesis protein B (ST2315) from Sulfolobus tokodaii. PMID:20054111
Structure of Trypanosoma brucei glutathione synthetase: domain and loop alterations in the catalytic cycle of a highly conserved enzyme. PMID:20045436
Catalysis and inhibition of Mycobacterium tuberculosis methionine aminopeptidase. PMID:20038112
The structure of the poxvirus A33 protein reveals a dimer of unique C-type lectin-like domains. PMID:20032175
Exploring peptide mimics for the production of antibodies against discontinuous protein epitopes. PMID:20031219
How baculovirus polyhedra fit square pegs into round holes to robustly package viruses. PMID:19959989
Structural insights into tail-anchored protein binding and membrane insertion by Get3. PMID:19948960
Substrate-mediated stabilization of a tetrameric drug target reveals Achilles heel in anthrax. PMID:19948665
The structure and NO binding properties of the nitrophorin-like heme-binding protein from Arabidopsis thaliana gene locus At1g79260.1. PMID:19938152
Crystal structure and molecular modeling study of N-carbamoylsarcosine amidase Ta0454 from Thermoplasma acidophilum. PMID:19932181
Structures of asymmetric ClpX hexamers reveal nucleotide-dependent motions in a AAA+ protein-unfolding machine. PMID:19914167
Macrophage scavenger receptor A mediates adhesion to apolipoproteins A-I and E. PMID:19911804
Structure of the nucleoprotein binding domain of Mokola virus phosphoprotein. PMID:19906936
ComSin: database of protein structures in bound (complex) and unbound (single) states in relation to their intrinsic disorder. PMID:19906708
Molecular basis for association of PIPKI gamma-p90 with clathrin adaptor AP-2. PMID:19903820
Evolution of protein binding modes in homooligomers. PMID:19879880
Crystal structure of the aspartyl-tRNA synthetase from Entamoeba histolytica. PMID:19874856
Thermodynamic and structural insights into CSL-DNA complexes. PMID:19866488
PDBe: Protein Data Bank in Europe. PMID:19858099
The crystal structure of the novobiocin biosynthetic enzyme NovP: the first representative structure for the TylF O-methyltransferase superfamily. PMID:19857499
Molecular architecture of the Nup84-Nup145C-Sec13 edge element in the nuclear pore complex lattice. PMID:19855394
Crystallization and preliminary X-ray diffraction analysis of crotoxin B from Crotalus durissus collilineatus venom. PMID:19851009
Inferred Biomolecular Interaction Server--a web server to analyze and predict protein interacting partners and binding sites. PMID:19843613
Crystal structure of the N-acetylmannosamine kinase domain of GNE. PMID:19841673
Crystal Structures of the histidine acid phosphatase from Francisella tularensis provide insight into substrate recognition. PMID:19836403
Structural plasticity of eph receptor A4 facilitates cross-class ephrin signaling. PMID:19836338
The crystal structures of macrophage migration inhibitory factor from Plasmodium falciparum and Plasmodium berghei. PMID:19827093
Crystal structure of the catalytic domain of the tumor-associated human carbonic anhydrase IX. PMID:19805286
Crystal structure of native RPE65, the retinoid isomerase of the visual cycle. PMID:19805034
Bioinformatics and structural characterization of a hypothetical protein from Streptococcus mutans: implication of antibiotic resistance. PMID:19798411
The structure of an integrin/talin complex reveals the basis of inside-out signal transduction. PMID:19798053
Crystal structure of a novel conformational state of the flavivirus NS3 protein: implications for polyprotein processing and viral replication. PMID:19793813
Crystal structure of a 3B3 variant--a broadly neutralizing HIV-1 scFv antibody. PMID:19785005
Crystal structure of a mammalian CTP: phosphocholine cytidylyltransferase catalytic domain reveals novel active site residues within a highly conserved nucleotidyltransferase fold. PMID:19783652
Predicting protein-protein binding sites in membrane proteins. PMID:19778442
Structure and inhibition of human diamine oxidase. PMID:19764817
Structure of the Yeast DEAD box protein Mss116p reveals two wedges that crimp RNA. PMID:19748356
Crystal structure and function of a DARPin neutralizing inhibitor of lactococcal phage TP901-1: comparison of DARPin and camelid VHH binding mode. PMID:19740746
Assessment of ligand binding residue predictions in CASP8. PMID:19714771
The crystal structure of the Escherichia coli autoinducer-2 processing protein LsrF. PMID:19714241
Model for eukaryotic tail-anchored protein binding based on the structure of Get3. PMID:19706470
Initial insight into the function of the lysosomal 66.3 kDa protein from mouse by means of X-ray crystallography. PMID:19706171
The crystal structure of Haloferax volcanii proliferating cell nuclear antigen reveals unique surface charge characteristics due to halophilic adaptation. PMID:19698123
Determinants for the activation and autoinhibition of the diguanylate cyclase response regulator WspR. PMID:19695263
Biochemical and structural characterization of alanine racemase from Bacillus anthracis (Ames). PMID:19695097
Structural redesign of lipase B from Candida antarctica by circular permutation and incremental truncation. PMID:19683009
Structural analysis of the GGDEF-EAL domain-containing c-di-GMP receptor FimX. PMID:19679088
Architectural nucleoporins Nup157/170 and Nup133 are structurally related and descend from a second ancestral element. PMID:19674973
Crystal structure of the frizzled-like cysteine-rich domain of the receptor tyrosine kinase MuSK. PMID:19664639
Dimerization of hepatitis E virus capsid protein E2s domain is essential for virus-host interaction. PMID:19662165
An asymmetric model for Na+-translocating glutaconyl-CoA decarboxylases. PMID:19654317
Structure and function of Bacillus subtilis YphP, a prokaryotic disulfide isomerase with a CXC catalytic motif. PMID:19653655
Structure and electrostatic property of cytoplasmic domain of ZntB transporter. PMID:19653298
Structure of the twin-arginine signal-binding protein DmsD from Escherichia coli. PMID:19652330
Impaired protofibril formation in fibrinogen gamma N308K is due to altered D:D and "A:a" interactions. PMID:19650644
The dimer formed by the periplasmic domain of EpsL from the Type 2 Secretion System of Vibrio parahaemolyticus. PMID:19646531
The structure of myostatin:follistatin 288: insights into receptor utilization and heparin binding. PMID:19644449
Structure of the C-terminal domain of nsp4 from feline coronavirus. PMID:19622868
Crystal structure of Miner1: The redox-active 2Fe-2S protein causative in Wolfram Syndrome 2. PMID:19580816
Crystal structure and assembly of the functional Nanoarchaeum equitans tRNA splicing endonuclease. PMID:19578064
Crystal packing analysis of murine VDAC1 crystals in a lipidic environment reveals novel insights on oligomerization and orientation. PMID:19574737
Structure of the vesicular stomatitis virus nucleocapsid in complex with the nucleocapsid-binding domain of the small polymerase cofactor, P. PMID:19571006
Optimized null model for protein structure networks. PMID:19557139
Structure and function of a complex between chorismate mutase and DAHP synthase: efficiency boost for the junior partner. PMID:19556970
The ATP-binding cassette family: a structural perspective. PMID:19544044
The three-dimensional structure of diaminopimelate decarboxylase from Mycobacterium tuberculosis reveals a tetrameric enzyme organisation. PMID:19543810
Molecular mimicry in innate immunity: crystal structure of a bacterial TIR domain. PMID:19535337
Crystal structure of protein Z-dependent inhibitor complex shows how protein Z functions as a cofactor in the membrane inhibition of factor X. PMID:19528533
Structural and phylogenetic analysis of a conserved actinobacteria-specific protein (ASP1; SCO1997) from Streptomyces coelicolor. PMID:19515238
ATP and MO25alpha regulate the conformational state of the STRADalpha pseudokinase and activation of the LKB1 tumour suppressor. PMID:19513107
Mutations of key hydrophobic surface residues of 11 beta-hydroxysteroid dehydrogenase type 1 increase solubility and monodispersity in a bacterial expression system. PMID:19507261
Extensive DNA mimicry by the ArdA anti-restriction protein and its role in the spread of antibiotic resistance. PMID:19506028
The structure of CrgA from Neisseria meningitidis reveals a new octameric assembly state for LysR transcriptional regulators. PMID:19474343
Structure of the sporulation histidine kinase inhibitor Sda from Bacillus subtilis and insights into its solution state. PMID:19465772
Structural insight into the essential PB1-PB2 subunit contact of the influenza virus RNA polymerase. PMID:19461581
Structural insight into function and regulation of carnitine palmitoyltransferase. PMID:19430727
The structure of a cytolytic alpha-helical toxin pore reveals its assembly mechanism. PMID:19421192
Structural and functional analyses of PAS domain interactions of the clock proteins Drosophila PERIOD and mouse PERIOD2. PMID:19402751
Chaperones of F1-ATPase. PMID:19383603
Crystal structure of Baeyer-Villiger monooxygenase MtmOIV, the key enzyme of the mithramycin biosynthetic pathway. PMID:19364090
Structure of Thermotoga maritima TM0439: implications for the mechanism of bacterial GntR transcription regulators with Zn2+-binding FCD domains. PMID:19307717
Structural insight into the activation mechanism of human pancreatic prophospholipase A2. PMID:19297324
Intrinsic disorder in protein interactions: insights from a comprehensive structural analysis. PMID:19282967
Control of protein oligomerization symmetry by metal coordination: C2 and C3 symmetrical assemblies through Cu(II) and Ni(II) coordination. PMID:19267481
Identification and structural analysis of type I collagen sites in complex with fibronectin fragments. PMID:19251642
Crystal structures of YkuI and its complex with second messenger cyclic Di-GMP suggest catalytic mechanism of phosphodiester bond cleavage by EAL domains. PMID:19244251
X-ray structure of Danio rerio secretagogin: A hexa-EF-hand calcium sensor. PMID:19241471
A survey of available tools and web servers for analysis of protein-protein interactions and interfaces. PMID:19240123
Structure and function of GlmU from Mycobacterium tuberculosis. PMID:19237750
The structure of CDK4/cyclin D3 has implications for models of CDK activation. PMID:19237555
Structure-function relationships of the outer membrane translocon Wza investigated by cryo-electron microscopy and mutagenesis. PMID:19236919
Crystal structure of KorA bound to operator DNA: insight into repressor cooperation in RP4 gene regulation. PMID:19190096
X-ray crystal structure of GarR-tartronate semialdehyde reductase from Salmonella typhimurium. PMID:19184529
AcsD catalyzes enantioselective citrate desymmetrization in siderophore biosynthesis. PMID:19182782
Crystal structure of a novel Sm-like protein of putative cyanophage origin at 2.60 A resolution. PMID:19173316
An unusually small dimer interface is observed in all available crystal structures of cytosolic sulfotransferases. PMID:19173308
Structural basis for catalysis of a tetrameric class IIa fructose 1,6-bisphosphate aldolase from Mycobacterium tuberculosis. PMID:19167403
A structural overview of the vertebrate prion proteins. PMID:19164911
The nature of the TRAP-Anti-TRAP complex. PMID:19164760
Heme uptake across the outer membrane as revealed by crystal structures of the receptor-hemophore complex. PMID:19144921
Structural and biophysical studies of the human IL-7/IL-7Ralpha complex. PMID:19141282
Loss of viral fitness and cross-recognition by CD8+ T cells limit HCV escape from a protective HLA-B27-restricted human immune response. PMID:19139562
Binding to DNA of the RNA-polymerase II C-terminal domain allows discrimination between Cdk7 and Cdk9 phosphorylation. PMID:19136461
Crystal structures of mite allergens Der f 1 and Der p 1 reveal differences in surface-exposed residues that may influence antibody binding. PMID:19136006
Protein structure homology modeling using SWISS-MODEL workspace. PMID:19131951
Dihydroorotase from the hyperthermophile Aquifex aeolicus is activated by stoichiometric association with aspartate transcarbamoylase and forms a one-pot reactor for pyrimidine biosynthesis. PMID:19128030
Crystal structure of procaspase-1 zymogen domain reveals insight into inflammatory caspase autoactivation. PMID:19117953
Crystal structure of the N-terminal domain of anaphase-promoting complex subunit 7. PMID:19091741
Data deposition and annotation at the worldwide protein data bank. PMID:19082769
Structure of the Notch1-negative regulatory region: implications for normal activation and pathogenic signaling in T-ALL. PMID:19075186
Genome and proteome annotation: organization, interpretation and integration. PMID:19019817
Mycobacterium tuberculosis glucosyl-3-phosphoglycerate synthase: structure of a key enzyme in methylglucose lipopolysaccharide biosynthesis. PMID:19015727
Specificity and reactivity in menaquinone biosynthesis: the structure of Escherichia coli MenD (2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1-carboxylate synthase). PMID:18983854
Vancomycin forms ligand-mediated supramolecular complexes. PMID:18983853
Identification of pharmacological chaperones for Gaucher disease and characterization of their effects on beta-glucocerebrosidase by hydrogen/deuterium exchange mass spectrometry. PMID:18972510
Structural and functional analysis of AsbF: origin of the stealth 3,4-dihydroxybenzoic acid subunit for petrobactin biosynthesis. PMID:18955706
Changes in quaternary structure in the signaling mechanisms of PAS domains. PMID:18942854
Structural and functional characterization of the c-terminal domain of the ecdysteroid phosphate phosphatase from bombyx mori reveals a new enzymatic activity. PMID:18937503
Identification of noncollagenous sites encoding specific interactions and quaternary assembly of alpha 3 alpha 4 alpha 5(IV) collagen: implications for Alport gene therapy. PMID:18930919
Three-dimensional structures of Pseudomonas aeruginosa PvcA and PvcB, two proteins involved in the synthesis of 2-isocyano-6,7-dihydroxycoumarin. PMID:18824174
Crystal structure and carbohydrate analysis of Nipah virus attachment glycoprotein: a template for antiviral and vaccine design. PMID:18815311
Computational structural analysis: multiple proteins bound to DNA. PMID:18802470
Crystal structure of the avian reovirus inner capsid protein sigmaA. PMID:18799570
A covalent linker allows for membrane targeting of an oxylipin biosynthetic complex. PMID:18785758
Crystal structure of human plasma platelet-activating factor acetylhydrolase: structural implication to lipoprotein binding and catalysis. PMID:18784071
Thioredoxin as a fusion tag for carrier-driven crystallization. PMID:18780816
PilF is an outer membrane lipoprotein required for multimerization and localization of the Pseudomonas aeruginosa Type IV pilus secretin. PMID:18776008
Structure of Staphylococcus aureus EsxA suggests a contribution to virulence by action as a transport chaperone and/or adaptor protein. PMID:18773907
The cysteine-rich interdomain region from the highly variable plasmodium falciparum erythrocyte membrane protein-1 exhibits a conserved structure. PMID:18773118
The structure of FSTL3.activin A complex. Differential binding of N-terminal domains influences follistatin-type antagonist specificity. PMID:18768470
The C-terminal region of Ge-1 presents conserved structural features required for P-body localization. PMID:18755833
Structural evidence for substrate-induced synergism and half-sites reactivity in biotin carboxylase. PMID:18725455
Structural analysis of a periplasmic binding protein in the tripartite ATP-independent transporter family reveals a tetrameric assembly that may have a role in ligand transport. PMID:18723845
Biochemical and structural insights of the early glycosylation steps in calicheamicin biosynthesis. PMID:18721755
Insights into the catalytic mechanism of tyrosine phenol-lyase from X-ray structures of quinonoid intermediates. PMID:18715865
Vaccinia virus proteins A52 and B14 Share a Bcl-2-like fold but have evolved to inhibit NF-kappaB rather than apoptosis. PMID:18704168
Structure of the C-terminal domain of the arginine repressor protein from Mycobacterium tuberculosis. PMID:18703843
Crystal structure of fosfomycin resistance kinase FomA from Streptomyces wedmorensis. PMID:18701452
PixE promotes dark oligomerization of the BLUF photoreceptor PixD. PMID:18695243
High affinity interaction between a bivalve C-type lectin and a biantennary complex-type N-glycan revealed by crystallography and microcalorimetry. PMID:18687680
A bony fish immunological receptor of the NITR multigene family mediates allogeneic recognition. PMID:18674935
Crystal packing of a bacteriophage MS2 coat protein mutant corresponds to octahedral particles. PMID:18662904
The crystal structure of CHIR-AB1: a primordial avian classical Fc receptor. PMID:18625238
Statistical analysis of interface similarity in crystals of homologous proteins. PMID:18599072
Crystal structure of the FeS cluster-containing nucleotide excision repair helicase XPD. PMID:18578568
Structure of Deinococcus radiodurans tunicamycin-resistance protein (TmrD), a phosphotransferase. PMID:18540055
Dimerization effect of sucrose octasulfate on rat FGF1. PMID:18540049
Structure of an Fab-protease complex reveals a highly specific non-canonical mechanism of inhibition. PMID:18514224
The structure of an archaeal homodimeric ligase which has RNA circularization activity. PMID:18511537
Comprehensive inventory of protein complexes in the Protein Data Bank from consistent classification of interfaces. PMID:18474114
Implications for kinetochore-microtubule attachment from the structure of an engineered Ndc80 complex. PMID:18455984
Structure of Staphylococcus aureus 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase. PMID:18453700
Structures of an alanine racemase from Bacillus anthracis (BA0252) in the presence and absence of (R)-1-aminoethylphosphonic acid (L-Ala-P). PMID:18453697
Intervening with urinary tract infections using anti-adhesives based on the crystal structure of the FimH-oligomannose-3 complex. PMID:18446213
Crystal structure of human liver Delta4-3-ketosteroid 5beta-reductase (AKR1D1) and implications for substrate binding and catalysis. PMID:18407998
Crystallographic and biochemical studies revealing the structural basis for antizyme inhibitor function. PMID:18369191
Dissecting protein-RNA recognition sites. PMID:18353859
Crystal structure of LpxC from Pseudomonas aeruginosa complexed with the potent BB-78485 inhibitor. PMID:18287278
Protein databases on the internet. PMID:18265344
Structure of HsaD, a steroid-degrading hydrolase, from Mycobacterium tuberculosis. PMID:18097091
The befores and afters of molecular replacement. PMID:18094463
Preliminary X-ray crystallographic studies of a tetrameric phospholipase A2 formed by two isoforms of crotoxin B from Crotalus durissus terrificus venom. PMID:18084096
Structure of the DNA repair helicase hel308 reveals DNA binding and autoinhibitory domains. PMID:18056710
Characterization of substrate binding and catalysis in the potential antibacterial target N-acetylglucosamine-1-phosphate uridyltransferase (GlmU). PMID:18029420
Structure of PlcR: Insights into virulence regulation and evolution of quorum sensing in Gram-positive bacteria. PMID:17998541
Structural basis for light-dependent signaling in the dimeric LOV domain of the photosensor YtvA. PMID:17764689
Dimerization of inositol monophosphatase Mycobacterium tuberculosis SuhB is not constitutive, but induced by binding of the activator Mg2+. PMID:17725819
PQS: a protein quaternary structure file server PubMed citations: 207.

207 articles citing: PQS: a protein quaternary structure file server

QSalignWeb: A Server to Predict and Analyze Protein Quaternary Structure. PMID:35071324
PDB-wide identification of physiological hetero-oligomeric assemblies based on conserved quaternary structure geometry. PMID:34520740
A mathematical representation of protein binding sites using structural dispersion of atoms from principal axes for classification of binding ligands. PMID:33831020
PremPS: Predicting the impact of missense mutations on protein stability. PMID:33378330
Structural basis of self-assembly in the lipid-binding domain of mycobacterial polar growth factor Wag31. PMID:32695423
Peroxidase activities of gold nanowires synthesized by TMV as template and their application in detection of cancer cells. PMID:32179948
The non-swapped monomeric structure of the arginine-binding protein from Thermotoga maritima. PMID:31702584
Accurate Classification of Biological and non-Biological Interfaces in Protein Crystal Structures using Subtle Covariation Signals. PMID:31471543
Principles and characteristics of biological assemblies in experimentally determined protein structures. PMID:30965224
Investigation of Core Structure and Stability of Human Pyruvate Dehydrogenase Complex: A Coarse-Grained Approach. PMID:30023628
Integrating co-evolutionary signals and other properties of residue pairs to distinguish biological interfaces from crystal contacts. PMID:29931702
Investigation of protein quaternary structure via stoichiometry and symmetry information. PMID:29864163
PDB-wide identification of biological assemblies from conserved quaternary structure geometry. PMID:29155427
Dockground: A comprehensive data resource for modeling of protein complexes. PMID:28891124
Protein-Protein Interactions in Virus-Host Systems. PMID:28861068
The "Sticky Patch" Model of Crystallization and Modification of Proteins for Enhanced Crystallizability. PMID:28573570
ProteinsPlus: a web portal for structure analysis of macromolecules. PMID:28472372
Prediction of interacting proteins from homology-modeled complex structures using sequence and structure scores. PMID:27857563
ClusPro-DC: Dimer Classification by the Cluspro Server for Protein-Protein Docking. PMID:27771482
Empirical power laws for the radii of gyration of protein oligomers. PMID:27710933
DOMMINO 2.0: integrating structurally resolved protein-, RNA-, and DNA-mediated macromolecular interactions. PMID:26827237
Understanding the fabric of protein crystals: computational classification of biological interfaces and crystal contacts. PMID:26508758
DynaFace: Discrimination between Obligatory and Non-obligatory Protein-Protein Interactions Based on the Complex's Dynamics. PMID:26506003
A structural dissection of large protein-protein crystal packing contacts. PMID:26370141
Stock-based detection of protein oligomeric states in jsPISA. PMID:25908787
Predicting protein interface residues using easily accessible on-line resources. PMID:25797794
An integrative approach to the study of filamentous oligomeric assemblies, with application to RecA. PMID:25785454
Algorithmic approaches to protein-protein interaction site prediction. PMID:25713596
Use B-factor related features for accurate classification between protein binding interfaces and crystal packing contacts. PMID:25522196
Structural templates for comparative protein docking. PMID:25488330
Structure-based characterization of multiprotein complexes. PMID:24954616
Scoring docking conformations using predicted protein interfaces. PMID:24906633
Factors correlating with significant differences between X-ray structures of myoglobin. PMID:24531482
Amino acid changes in disease-associated variants differ radically from variants observed in the 1000 genomes project dataset. PMID:24348229
MP:PD--a data base of internal packing densities, internal packing defects and internal waters of helical membrane proteins. PMID:24194596
An analysis of oligomerization interfaces in transmembrane proteins. PMID:24134166
Structural rearrangement in an RsmA/CsrA ortholog of Pseudomonas aeruginosa creates a dimeric RNA-binding protein, RsmN. PMID:23954502
PepBind: a comprehensive database and computational tool for analysis of protein-peptide interactions. PMID:23896518
Evolutionary, physicochemical, and functional mechanisms of protein homooligomerization. PMID:23663963
Inferring homologous protein-protein interactions through pair position specific scoring matrix. PMID:23367879
Exploring the binding diversity of intrinsically disordered proteins involved in one-to-many binding. PMID:23233352
PDBTM: Protein Data Bank of transmembrane proteins after 8 years. PMID:23203988
Influence of structural symmetry on protein dynamics. PMID:23189176
An assignment of intrinsically disordered regions of proteins based on NMR structures. PMID:23142703
Structure-based prediction of protein-protein interactions on a genome-wide scale. PMID:23023127
Crystal structure of mouse RhoA:GTPγS complex in a centered lattice. PMID:23001747
Prediction of phenotypes of missense mutations in human proteins from biological assemblies. PMID:22965855
Alternative protein-protein interfaces are frequent exceptions. PMID:22876170
Analysis of domain-swapped oligomers reveals local sequence preferences and structural imprints at the linker regions and swapped interfaces. PMID:22848353
Protein-protein interaction site predictions with three-dimensional probability distributions of interacting atoms on protein surfaces. PMID:22701576
Exploring protein dynamics space: the dynasome as the missing link between protein structure and function. PMID:22606222
Identification of binding pockets in protein structures using a knowledge-based potential derived from local structural similarities. PMID:22536963
Mutagenesis of the bovSERPINA3-3 demonstrates the requirement of aspartate-371 for intermolecular interaction and formation of dimers. PMID:22505318
Progressive dry-core-wet-rim hydration trend in a nested-ring topology of protein binding interfaces. PMID:22452998
Predicting protein-protein interface residues using local surface structural similarity. PMID:22424103
Composite structural motifs of binding sites for delineating biological functions of proteins. PMID:22347478
Homology inference of protein-protein interactions via conserved binding sites. PMID:22303436
Protein docking prediction using predicted protein-protein interface. PMID:22233443
DOMMINO: a database of macromolecular interactions. PMID:22135305
Structural and functional protein network analyses predict novel signaling functions for rhodopsin. PMID:22108793
Structural annotation of Mycobacterium tuberculosis proteome. PMID:22073123
Unfurling of the band 4.1, ezrin, radixin, moesin (FERM) domain of the merlin tumor suppressor. PMID:22012890
A novel method for protein-protein interaction site prediction using phylogenetic substitution models. PMID:21989996
3DSwap: curated knowledgebase of proteins involved in 3D domain swapping. PMID:21959866
Discrimination between biological interfaces and crystal-packing contacts. PMID:21918609
Multicoil2: predicting coiled coils and their oligomerization states from sequence in the twilight zone. PMID:21901122
Comprehensive, atomic-level characterization of structurally characterized protein-protein interactions: the PICCOLO database. PMID:21801404
Characterization of protein-protein interaction interfaces from a single species. PMID:21738603
PredUs: a web server for predicting protein interfaces using structural neighbors. PMID:21609948
DEPTH: a web server to compute depth and predict small-molecule binding cavities in proteins. PMID:21576233
Insights from the structural analysis of protein heterodimer interfaces. PMID:21572879
Caught in self-interaction: evolutionary and functional mechanisms of protein homooligomerization. PMID:21572178
Macromolecular complexes in crystals and solutions. PMID:21460456
The Protein Data Bank in Europe (PDBe): bringing structure to biology. PMID:21460450
Cell cycle sensing of oxidative stress in Saccharomyces cerevisiae by oxidation of a specific cysteine residue in the transcription factor Swi6p. PMID:21147769
Catalytic residues in hydrolases: analysis of methods designed for ligand-binding site prediction. PMID:21104192
Concept and application of a computational vaccinology workflow. PMID:21067549
SAHG, a comprehensive database of predicted structures of all human proteins. PMID:21051360
Mechanisms of protein oligomerization, the critical role of insertions and deletions in maintaining different oligomeric states. PMID:21048085
The RCSB Protein Data Bank: redesigned web site and web services. PMID:21036868
The protein common interface database (ProtCID)--a comprehensive database of interactions of homologous proteins in multiple crystal forms. PMID:21036862
Detection and alignment of 3D domain swapping proteins using angle-distance image-based secondary structural matching techniques. PMID:20976204
Structure of a tryptophanyl-tRNA synthetase containing an iron-sulfur cluster. PMID:20944229
Promoting a structural view of biology for varied audiences: an overview of RCSB PDB resources and experiences. PMID:20877496
M-ORBIS: mapping of molecular binding sites and surfaces. PMID:20813758
Insights into Protein Sequence and Structure-Derived Features Mediating 3D Domain Swapping Mechanism using Support Vector Machine Based Approach. PMID:20634983
PDBWiki: added value through community annotation of the Protein Data Bank. PMID:20624717
Three-dimensional structure of the weakly associated protein homodimer SeR13 using RDCs and paramagnetic surface mapping. PMID:20589905
Beauty is in the eye of the beholder: proteins can recognize binding sites of homologous proteins in more than one way. PMID:20585553
In silico structure-function analysis of pathological variation in the HSD11B2 gene sequence. PMID:20571110
MuD: an interactive web server for the prediction of non-neutral substitutions using protein structural data. PMID:20542913
Protein interface conservation across structure space. PMID:20534496
dockYard--a repository to assist modeling of protein-protein docking. PMID:20524020
Diversity of function-related conformational changes in proteins: coordinate uncertainty, fragment rigidity, and stability. PMID:20469886
Testing computational prediction of missense mutation phenotypes: functional characterization of 204 mutations of human cystathionine beta synthase. PMID:20455263
Quality assessment of protein model-structures using evolutionary conservation. PMID:20385730
Oligomeric interfaces under the lens: gemini. PMID:20360856
Diffusion, crowding & protein stability in a dynamic molecular model of the bacterial cytoplasm. PMID:20221255
Thermo- and mesostabilizing protein interactions identified by temperature-dependent statistical potentials. PMID:20159163
Comparative evolutionary analysis of protein complexes in E. coli and yeast. PMID:20122144
Structure of YqgQ protein from Bacillus subtilis, a conserved hypothetical protein. PMID:20057058
Predicting protein ligand binding sites by combining evolutionary sequence conservation and 3D structure. PMID:19997483
Prediction of protein binding sites in protein structures using hidden Markov support vector machine. PMID:19925685
Evolution of protein binding modes in homooligomers. PMID:19879880
Structural imperatives impose diverse evolutionary constraints on helical membrane proteins. PMID:19815527
The crystal structure of the AF2331 protein from Archaeoglobus fulgidus DSM 4304 forms an unusual interdigitated dimer with a new type of alpha + beta fold. PMID:19768810
Alteration of oligomeric state and domain architecture is essential for functional transformation between transferase and hydrolase with the same scaffold. PMID:19670211
MM-align: a quick algorithm for aligning multiple-chain protein complex structures using iterative dynamic programming. PMID:19443443
A survey of available tools and web servers for analysis of protein-protein interactions and interfaces. PMID:19240123
Identification of DNA-binding proteins using structural, electrostatic and evolutionary features. PMID:19233205
The oligomerization of OxyR in Escherichia coli. PMID:19177355
Exploiting genomic patterns to discover new supramolecular protein assemblies. PMID:19177352
Crystal structure of a novel Sm-like protein of putative cyanophage origin at 2.60 A resolution. PMID:19173316
An unusually small dimer interface is observed in all available crystal structures of cytosolic sulfotransferases. PMID:19173308
VASCo: computation and visualization of annotated protein surface contacts. PMID:19166624
Protein structure homology modeling using SWISS-MODEL workspace. PMID:19131951
Questioning the ubiquity of neofunctionalization. PMID:19119408
Data deposition and annotation at the worldwide protein data bank. PMID:19082769
Homology modelling of protein-protein complexes: a simple method and its possibilities and limitations. PMID:18844985
CC+: a relational database of coiled-coil structures. PMID:18842638
Built-in loops allow versatility in domain-domain interactions: lessons from self-interacting domains. PMID:18757736
Representation of viruses in the remediated PDB archive. PMID:18645236
Architectures and functional coverage of protein-protein interfaces. PMID:18620705
Statistical analysis of interface similarity in crystals of homologous proteins. PMID:18599072
SODa: an Mn/Fe superoxide dismutase prediction and design server. PMID:18518943
Comprehensive inventory of protein complexes in the Protein Data Bank from consistent classification of interfaces. PMID:18474114
HOMCOS: a server to predict interacting protein pairs and interacting sites by homology modeling of complex structures. PMID:18442990
Overview of protein structural and functional folds. PMID:18429251
The contrasting properties of conservation and correlated phylogeny in protein functional residue prediction. PMID:18221517
Mapping of protein-protein interaction sites by the 'absence of interference' approach. PMID:18191145
SCOWLP classification: structural comparison and analysis of protein binding regions. PMID:18182098
Identification of transient hub proteins and the possible structural basis for their multiple interactions. PMID:18156468
MrBUMP: an automated pipeline for molecular replacement. PMID:18094475
Remediation of the protein data bank archive. PMID:18073189
Identifying the subproteome of kinetically stable proteins via diagonal 2D SDS/PAGE. PMID:17956990
LigASite--a database of biologically relevant binding sites in proteins with known apo-structures. PMID:17933762
DOMINE: a database of protein domain interactions. PMID:17913741
M-TASSER: an algorithm for protein quaternary structure prediction. PMID:17905848
Structure-templated predictions of novel protein interactions from sequence information. PMID:17892321
Characterization of protein-protein interfaces. PMID:17851740
Visualization software for molecular assemblies. PMID:17728125
Versatile annotation and publication quality visualization of protein complexes using POLYVIEW-3D. PMID:17727718
Recognizing protein-protein interfaces with empirical potentials and reduced amino acid alphabets. PMID:17662112
Domain folding and flexibility of Escherichia coli FtsZ determined by tryptophan site-directed mutagenesis. PMID:17656575
Crystal structure of an acetyltransferase protein from Vibrio cholerae strain N16961. PMID:17623843
The role of hydrophobic interactions in positioning of peripheral proteins in membranes. PMID:17603894
Structural features differentiate the mechanisms between 2S (2 state) and 3S (3 state) folding homodimers. PMID:17597851
Crystal structure of a transcriptional regulator TM1030 from Thermotoga maritima solved by an unusual MAD experiment. PMID:17588774
Protein interactions from complexes: a structural perspective. PMID:17538689
Exploiting residue-level and profile-level interface propensities for usage in binding sites prediction of proteins. PMID:17480235
PMG: online generation of high-quality molecular pictures and storyboarded animations. PMID:17478496
Relating destabilizing regions to known functional sites in proteins. PMID:17470296
Specificity in protein interactions and its relationship with sequence diversity and coevolution. PMID:17468399
Evolution of protein complexes by duplication of homomeric interactions. PMID:17411433
Mechanisms for stabilisation and the maintenance of solubility in proteins from thermophiles. PMID:17394655
SNAPPI-DB: a database and API of Structures, iNterfaces and Alignments for Protein-Protein Interactions. PMID:17202171
So how do you know you have a macromolecular complex? PMID:17164522
Macromolecular recognition in the Protein Data Bank. PMID:17164520
The worldwide Protein Data Bank (wwPDB): ensuring a single, uniform archive of PDB data. PMID:17142228
Amino acid residue doublet propensity in the protein-RNA interface and its application to RNA interface prediction. PMID:17130160
3D complex: a structural classification of protein complexes. PMID:17112313
Structural modeling of protein interactions by analogy: application to PSD-95. PMID:17096593
An approach to crystallizing proteins by synthetic symmetrization. PMID:17050682
The many faces of protein-protein interactions: A compendium of interface geometry. PMID:17009862
Structure of YidB protein from Shigella flexneri shows a new fold with homeodomain motif. PMID:16927377
ProSAT2--Protein Structure Annotation Server. PMID:16845114
oGNM: online computation of structural dynamics using the Gaussian Network Model. PMID:16845002
PreBI: prediction of biological interfaces of proteins in crystals. PMID:16844993
Wiggle-predicting functionally flexible regions from primary sequence. PMID:16839194
Protein complex compositions predicted by structural similarity. PMID:16738133
Positioning of proteins in membranes: a computational approach. PMID:16731967
An integrated approach to the prediction of domain-domain interactions. PMID:16725050
An algorithm for predicting protein-protein interaction sites: Abnormally exposed amino acid residues and secondary structure elements. PMID:16641487
Structure of SAICAR synthase from Thermotoga maritima at 2.2 angstroms reveals an unusual covalent dimer. PMID:16582479
A new generation of statistical potentials for proteins. PMID:16533849
The origins and evolution of functional modules: lessons from protein complexes. PMID:16524839
The ybeY protein from Escherichia coli is a metalloprotein. PMID:16511207
Crystal structure of hypothetical protein YfiH from Shigella flexneri at 2 A resolution. PMID:16498617
NOXclass: prediction of protein-protein interaction types. PMID:16423290
The SWISS-MODEL Repository: new features and functionalities. PMID:16381875
SCOPPI: a structural classification of protein-protein interfaces. PMID:16381874
MODBASE: a database of annotated comparative protein structure models and associated resources. PMID:16381869
E-MSD: improving data deposition and structure quality. PMID:16381867
Oligomeric protein structure networks: insights into protein-protein interactions. PMID:16336694
On the Quaternary Assembly of Spinach Chloroplast Thioredoxin m. PMID:16328794
High-throughput protein production for X-ray crystallography and use of size exclusion chromatography to validate or refute computational biological unit predictions. PMID:16211510
How do side chains orient globally in protein structures? PMID:16152644
Interaction preferences across protein-protein interfaces of obligatory and non-obligatory components are different. PMID:16105176
Localization of protein-binding sites within families of proteins. PMID:16081657
Crystal structure of botulinum neurotoxin type G light chain: serotype divergence in substrate recognition. PMID:16008342
Gamma carbonic anhydrases in plant mitochondria. PMID:15604675
Biomolecular rods and tubes in nanotechnology. PMID:15558225
Implications for domain fusion protein-protein interactions based on structural information. PMID:15504241
Computational protein design is a challenge for implicit solvation models. PMID:15377512
Identification and mapping of self-assembling protein domains encoded by the Escherichia coli K-12 genome by use of lambda repressor fusions. PMID:14973045
The distribution and query systems of the RCSB Protein Data Bank. PMID:14681399
From protein structure to biochemical function? PMID:14649301
Beta edge strands in protein structure prediction and aggregation. PMID:14500893
SWISS-MODEL: An automated protein homology-modeling server. PMID:12824332
SEM (Symmetry Equivalent Molecules): A web-based GUI to generate and visualize the macromolecules. PMID:12824326
Crystal structure of a trimeric form of dephosphocoenzyme A kinase from Escherichia coli. PMID:12538896
E-MSD: the European Bioinformatics Institute Macromolecular Structure Database. PMID:12520052
Structural basis for the oxidation of thiosulfate by a sulfur cycle enzyme. PMID:12411478
Human non-synonymous SNPs: server and survey. PMID:12202775
Amino acid-base interactions: a three-dimensional analysis of protein-DNA interactions at an atomic level. PMID:11433033
Three-dimensional structure of the lithostathine protofibril, a protein involved in Alzheimer's disease. PMID:11432819
Identification of protein oligomerization states by analysis of interface conservation. PMID:11248019

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protein
metasource: Fairsharing.org
version: FAIRsharing.org: PDBePISA; Protein Data Bank: Proteins, Interfaces, Structures and Assemblies; DOI: https://doi.org/10.25504/FAIRsharing.nm2z1h; Last edited: Feb. 10, 2020, 5:13 p.m.; Last accessed: Jan 03 2022 7:08 p.m.

structure
metasource: Fairsharing.org
version: FAIRsharing.org: PDBePISA; Protein Data Bank: Proteins, Interfaces, Structures and Assemblies; DOI: https://doi.org/10.25504/FAIRsharing.nm2z1h; Last edited: Feb. 10, 2020, 5:13 p.m.; Last accessed: Jan 03 2022 7:08 p.m.

x-ray diffraction
metasource: Fairsharing.org
version: FAIRsharing.org: PDBePISA; Protein Data Bank: Proteins, Interfaces, Structures and Assemblies; DOI: https://doi.org/10.25504/FAIRsharing.nm2z1h; Last edited: Feb. 10, 2020, 5:13 p.m.; Last accessed: Jan 03 2022 7:08 p.m.

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Compilation and Creation of datasets from PDB

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