ALSoD

Other names: ALS Online Database, Amyotrophic Lateral Sclerosis Online genetics Database

ALSoD is a freely available database that has been transformed from a single gene storage facility recording mutations in the SOD1 gene to a multigene ALS bioinformatics repository and analytical instrument combining genotype, phenotype, and geographical information with associated analysis tools. These include a comparison tool to evaluate genes side by side or jointly with user configurable features, a pathogenicity prediction tool using a combination of computational approaches to distinguish variants with nonfunctional characteristics from disease-associated mutations with more dangerous consequences, and a credibility tool to enable ALS researchers to objectively assess the evidence for gene causation in ALS. Furthermore, integration of external tools, systems for feedback, annotation by users, and two-way links to collaborators hosting complementary databases further enhance the functionality of ALSoD.

Webpage:
https://alsod.ac.uk/

Licence:
Name: other
URL: http://alsod.iop.kcl.ac.uk/home.aspx

Tags:

als amyotrophic lateral sclerosis hgmd cardiff nomenclature sod1 genetic mutations bioinformatics clinical details familiy details genetics neuropathology

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